Tumor t cell immunity. Medical search. Frequent questions

CD4 + T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. (nature.com)
These data suggested that miRs 130a and 145 skewed a pro-tumor toward an anti-tumor microenvironment via reprogrammed immature myeloid cells. (nih.gov)
Targeting Tregs to reestablish the proinflammatory and immunogenic tumor microenvironment (TME) is an increasingly attractive strategy for cancer treatment and has been emphasized in recent years. (biomedcentral.com)
It has been suggested that tumor necroptosis affects tumor progression through modulating the tumor microenvironment. (biomedcentral.com)
These animal studies revealed that IL-12 experienced a profound and beneficial effect on the tumor microenvironment. (ecologicalsgardens.com)
The impact of IL-12 Schisantherin B was dependent on the expression of the IL-12 receptor on host cells and not on Schisantherin B its expression on the transferred cells further emphasizing the role of IL-12 in altering the tumor microenvironment. (ecologicalsgardens.com)
Phenotype switching: plasticity and/or differentiation of stromal cells and their progenitors within the tumour microenvironment regulate tumour fate. (europa.eu)
Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)
Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
These CAR-MΦs were able to seek and engulf GSCs and clear residual GSCs by stimulating an adaptive antitumor immune response in the tumor microenvironment and prevented postoperative glioma relapse by inducing long-term antitumor immunity in mice. (nih.gov)
It was further demonstrated that Th17 cells could be induced and expanded in the tumor microenvironment through cytokines produced by the tumor cells. (spandidos-publications.com)
Previous studies have confirmed that tumor immune inflammation is important in the tumor microenvironment ( 6 ). (spandidos-publications.com)
In addition, the LSCC microenvironment was identified as a strong Th17-cell inducer. (spandidos-publications.com)
Mar. 28, 2023 Cancer-associated fibroblasts (CAFs) are key factors in the tumor microenvironment, which have been implicated in cancer cell progression. (sciencedaily.com)
One of the reasons that cancer is so difficult to prevent is the complex interaction between individual cancer cells and the tumor microenvironment. (medicalnewstoday.com)
This study provides fundamental insight into the functional impact of CDK4 inhibition on cells in the tumor microenvironment, which is of high importance and interest to the field. (elifesciences.org)
Breakthroughs in anti-tumor immunity have led to unprecedented advances in immunotherapy, yet it is now clear that the tumor microenvironment (TME) restrains immunity. (elifesciences.org)
As T cell metabolism dictates effector function, it is now apparent that the effect of cancer cell metabolism on the tumor microenvironment (TME) may impair anti-tumor immunity, and these new hallmarks of cancer are therefore inextricably linked. (elifesciences.org)

Recent studies using neutralizing anti-CCL5 antibodies have suggested that the constitutive expression of CCL5 plays a regulatory role in maintaining tissue-resident memory (Trm) T cells in the human vaginal tract 9 and mouse skin 10 , suggesting that constitutive CCL5 expression in noninflamed conditions, hereafter referred to as homeostatic CCL5 expression, might be important for homeostasis of tissue-resident lymphocytes. (nature.com)
Background gdT-cells are innate-like lymphocytes described as potent killer of cancer cells whose infiltration into tumors is associated with a positive prognosis. (bmj.com)
Mechanically, miRs 130a and 145 overexpression in Gr1+CD11b+myeloid cells decreased Th2 cytokine production, and increased IFNg producing CD8+ cytotoxic lymphocytes. (nih.gov)
Immunization of mice with TERT RNA-transfected dendritic cells (DC) stimulated cytotoxic T lymphocytes (CTL), which lysed melanoma and thymoma tumor cells and inhibited the growth of three unrelated tumors in mice of distinct genetic backgrounds. (nova.edu)
Cell-specific subscriber base of mantle cell lymphoma-derived exosomes by cancerous and non-malignant B-lymphocytes. (research-in-field.com)
Shabtai Meters, Ye L, Frischer Z ., Martin M, Waltzer WC, Malinowski E. Improved appearance of service guns in renal cell carcinoma infiltrating lymphocytes. (research-in-field.com)
Natural killer T (NKT) cells comprise a subset of lymphocytes originating from a distinct developmental lineage [ 1 ] which bridge innate and adaptive immunity and modulate immune responses in autoimmunity, malignancies and infections [ 2 ]. (biomedcentral.com)
Introduction Adoptive cell therapy (Take action) using autologous tumor infiltrating lymphocytes (TIL) and high dose IL-2 preceded by the administration of a non-myeloablative lymphodepleting regimen mediates objective tumor regression in 50%-70% of melanoma patients based on RECIST (responsive evaluation criteria in solid tumor)[1]. (ecologicalsgardens.com)
Additionally Take action using genetic modification of peripheral blood lymphocytes (PBL) with anti-tumor receptors can mediate regression in multiple malignancy Sele histologies[2-5]. (ecologicalsgardens.com)
This review will discuss the metabolic changes that drive T cells into different stages of their development and how the TME imposes barriers to the metabolism and activity of tumor infiltrating lymphocytes. (elifesciences.org)
Chromosomal aberrations (hypo- and hyperdiploidy, deletions, breaks, and gaps) in peripheral lymphocytes and bone marrow cells are the predominant effects seen in humans. (cdc.gov)
Comparison of tumor biopsies before and after treatment reveals an increase of activated, conventional CD4+ tumor-infiltrating lymphocytes (TIL) in most patients and higher clonality by TCRβ sequencing. (bepress.com)
Human primary tumor cells could also be reprogrammed to increase their capability to present antigen and to activate patient-specific tumor-infiltrating lymphocytes. (lu.se)
Activation of helper T cells also drives their secretion of tumor necrosis factor α, which attracts additional macrophages and lymphocytes and promotes granuloma formation to control the spread of M. tuberculosis ( 3 ). (cdc.gov)
Tumor-infiltrating lymphocytes (TILs) may have greater tumoricidal activity than LAK cells. (msdmanuals.com)
IgAD is commonly associated with normal B lymphocytes in peripheral blood, normal CD4 + and CD8 + T cells, and, usually, normal neutrophil and lymphocyte counts. (medscape.com)
B and T lymphocytes, CD4+ B lymphocytes versus CD8+ T lymphocytes), and tests that measure T-cell proliferation or function in response to specific or nonspecific stimuli (e.g., lymphocyte proliferation assays) ( 4,5 ). (cdc.gov)

Deletion of the proximal enhancer decreases CCL5 expression and augments the cytotoxic activity of tissue-resident T and NK cells, which coincides with reduced melanoma metastasis in mouse models. (nature.com)
By contrast, increased CCL5 expression resulting from RUNX3 mutation is associated with more tumor metastasis in the lung. (nature.com)
Furthermore, a recent clinical trial for a CCR5 inhibitor treatment to patients suffering from liver metastasis of colorectal cancer showed its effect on reducing tumor mass with better prognosis, suggesting CCL5-CCR5 axis might also provide a procancer activity 22 . (nature.com)
Immature myeloid cells, identified as Gr1+CD11b+ cells, are expanded in tumor bearing host, and promote distant organ metastasis in tumor bearing host through production of immunosuppressive cytokines and chemokines. (nih.gov)
Previous studies showed that myeloid specific transforming growth factor beta (TGF¿) signaling is essential for tumor metastasis. (nih.gov)
Using Lys-Cre mediated myeloid specific Tgfbr2 knockout mice, TGF¿ type II receptor (TbRII) in myeloid cells inhibit tumor metastasis. (nih.gov)
To examine whether miRs130a and 145 inhibit lung metastasis via down-regulation of T¿RII in immature myeloid cells, we used 2 different mouse models with myeloid specific miR130a or miR145 overexpression: 1) 4T1 tumor model transplanted with CD11b driven-miR130a or miR145 engineered bone marrow haematopoietic stem /progenitor cells and 2) Lewis lung carcinoma model with doxycycline-inducible myeloid specific miR130a transgenic mice. (nih.gov)
Ectopic miR130a or miR145 expression decreased T¿RII expression in Gr1+CD11b+ cells and significantly inhibited lung metastasis. (nih.gov)
IGF1R inhibitor NT157 also decreased lung metastasis via improved anti-tumor immunity. (nih.gov)
To evaluate therapeutic potentials of miRs130a and 145 mimics for lung metastasis, we used a preclinical mouse model with 4T1 mammary tumor. (nih.gov)
Taken together, these data suggested that miR130a and miR145 reprogramed Gr1+CD11b+ immature myeloid cells, and inhibited tumor metastasis via improvement of anti-tumor immunity. (nih.gov)
Restoration of miRs 130a and 145 functions in immature myeloid cells might be useful for reduction of tumor metastasis. (nih.gov)
Tumor necroptosis often happens in advanced solid tumors, and blocking necroptosis by MLKL deletion in breast cancer dramatically reduces tumor metastasis. (biomedcentral.com)
However, the exact mechanism by which tumor necroptosis promotes tumor metastasis remains elusive. (biomedcentral.com)
Here, we report that the ectodomain shedding of cell surface proteins of necroptotic cells is critical for the promoting effect of tumor necroptosis in tumor metastasis through inhibiting the anti-tumor activity of T cells. (biomedcentral.com)
We found that blocking tumor necroptosis by MLKL deletion led to the dramatic reduction of tumor metastasis and significantly elevated anti-tumor activity of tumor-infiltrating and peripheral blood T cells. (biomedcentral.com)
Importantly, the increased anti-tumor activity of T cells is a key cause for the reduced metastasis as the depletion of CD8+ T cells completely restored the level of metastasis in the Mlkl KO mice. (biomedcentral.com)
Interestingly, the levels of some soluble cell surface proteins including sE-cadherin that are known to promote metastasis are also dramatically reduced in MLKL null tumors/mice. (biomedcentral.com)
Administration of ADAMs pan inhibitor reduces the levels of soluble cell surface proteins in WT tumors/mice and leads to the dramatic decrease in metastasis. (biomedcentral.com)
Finally, we showed the sE-cadherin/KLRG1 inhibitory receptor is the major pathway for necroptosis-mediated suppression of the anti-tumor activity of T cells and the promotion of metastasis. (biomedcentral.com)
Hence, our study reveals a novel mechanism of tumor necroptosis-mediated promotion of metastasis and suggests that tumor necroptosis and necroptosis-activated ADAMs are potential targets for controlling metastasis. (biomedcentral.com)
Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
Angiogenesis, the growth of new blood vessels, occurs at different stages during embryonic development, physiological processes such as wound healing and reproduction, and numerous diseases, including inflammation, tumor progression, and metastasis [ 1 ]. (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)
The tumor staging of the patients was performed in accordance with the American Joint Committee on Cancer tumor-node metastasis (TNM) classification ( 12 ). (spandidos-publications.com)
In the future, the team hopes that clinicians will use this microfluidic device to examine tumor biopsies to estimate the likelihood of metastasis and adjust treatment at earlier disease stages. (news-medical.net)
Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach. (medscape.com)

Immunization with tumor RNA was generally more effective than immunization with TERT RNA, suggesting that an optimal immunization protocol may have to include TERT as well as additional tumor antigens. (nova.edu)
More recently the laboratory has been involved in the definition of novel T cell antigens. (cardiff.ac.uk)
CD40 is also essential for directing the humoral response to T-cell-dependent antigens. (nih.gov)
Long-term studies on T cells in a cohort of patients vaccinated against yellow fever revealed that vaccine-induced CD8+ TSCM cells specific to yellow fever antigens were stably maintained for 25 years, capable of self-renewal ex vivo, and preserved surface markers and mRNA profiles closest to naïve T cells. (wikipedia.org)
0.05), suggesting the selective elimination of DCs cross-presenting tumor-associated antigens by iNKT cells. (biomedcentral.com)
July 5, 2023 A new vaccine boosts the response of engineered CAR-T cells and helps the immune system generate T cells that target other tumor antigens. (sciencedaily.com)
Our approach serves as a platform for the development of immunotherapies that endow cancer cells with the capability to process and present endogenous tumor antigens. (lu.se)
By using direct reprogramming strategies, I could induce the expression of tumor antigens on the surface of cancer cells, making them visible to the immune system again. (lu.se)
when it comes to cancer they are critical as they present tumor antigens to the killer cells of the immune system and orchestrate the anti-tumor immune response. (lu.se)
Tumor Antigens Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
Concomitant use of interferon enhances the expression of major histocompatibility complex (MHC) antigens and TAAs on tumor cells, thereby augmenting the killing of tumor cells by the infused effector cells. (msdmanuals.com)
Antibodies targeting two tumor antigens and CD3 are being tested. (msdmanuals.com)

Because of its powerful pro-inflammatory activities and its multiple functions in bridging innate and adaptive immunity[6] interleukin 12 (IL-12) was chosen for study first in pre-clinical models and as reported here in a phase 1 clinical trial in patients with metastatic melanoma. (ecologicalsgardens.com)
5, 2023 Researchers have revealed that the expression of a specific isoform of GREB1 Is4 is induced in malignant melanoma cells by the melanocyte-specific transcription factor, MITF. (sciencedaily.com)
July 27, 2023 Investigators have designed an innovative RNA-based strategy to activate dendritic cells--which play a key role in immune response -- that eradicated tumors and prevented their recurrence in mouse models of melanoma. (sciencedaily.com)
Studies published today in Nature conclude that enrichment of B cells, a type of immune cell known for producing antibodies, in TLS was predictive of response to checkpoint blockade in patients with melanoma , soft-tissue sarcomas and renal cell carcinomas (RCC). (mdanderson.org)
Injection of in vitro generated melanoma-derived tumor-APCs into subcutaneous melanoma tumors delayed tumor growth and increased survival in mice. (lu.se)
Patients and Methods Atezolizumab data from clinical trials in non-small-cell lung cancer, metastatic urothelial carcinoma, renal cell carcinoma, and melanoma were evaluated. (medscape.com)
Immune-related response criteria (irRC) were developed based on experience with ipilimumab (anti-cytotoxic T-cell lymphocyte-4) in melanoma to better capture the response to CIT per changes in tumor biology and the long-termeffects of CITon solid tumors and to enable additional adaptations as the field evolved. (medscape.com)

On the contrary, recent studies using CCL5 knockout mice showed that the total absence of host CCL5 exhibits increased antitumor immunity in breast cancer models, proposing a unique procancer role of host CCL5 20 , 21 . (nature.com)
Immunocompromised mice bearing human tumors and adoptively transferred with human g9d2 T cells were used to assess ICT01 anti-tumor activity in vivo. (bmj.com)
Interestingly, tumors from D-hep cells, not Hepa1-6 cells, regressed in wild-type C57BL/6 mice whereas D-hep cells exhibited similar tumorigenesis as Hep1-6 cells in immunodeficient mice. (oncotarget.com)
As expected, additional Hepa1-6 cells failed to form tumors in the D-hep-C57 mice in which D-hep cells were eliminated. (oncotarget.com)
Further research confirmed that D-hep-C57 mice established anti-tumor immunity against Hepa1-6 cells. (oncotarget.com)
TSCM infusion led to a more sustained reduction in tumor growth and correlated with a significant increase in overall survival of treated mice. (wikipedia.org)
Surprisingly, we previously found that mice deficient in iNKT cells developed spontaneous CD8 + T cells responses partially effective at inhibiting metastases in mice bearing the 4T1 mammary carcinoma, and showed a markedly improved response to treatment with local radiotherapy and anti-CTLA-4 antibody compared to wild type (WT) mice. (biomedcentral.com)
To understand the mechanisms of the immunosuppressive function of iNKT cells, dendritic cells (DCs) were analyzed by immunohistochemistry and flow cytometry in WT and iNKT-deficient (iNKT −/− ) mice. (biomedcentral.com)
To determine if the improved response to treatment in the absence of iNKT cells was independent from the immunotherapy employed, 4T1-tumor bearing WT and iNKT −/− mice were treated with local radiotherapy in combination with antibody-mediated CD137 co-stimulation. (biomedcentral.com)
Consistently, priming of T cells to a tumor-specific CD8 T cell epitope in mice treated with radiotherapy and anti-CTLA-4 or anti-CD137 was markedly enhanced in iNKT −/− compared to WT mice. (biomedcentral.com)
CD1d blockade restored the number of DC in WT mice, improved T cell priming in draining lymph nodes and significantly enhanced response to treatment. (biomedcentral.com)
In mice these myeloid derived cells can be reprogrammed by IL-12 from immunosuppressors to immunostimulatory cells [9]. (ecologicalsgardens.com)

Here we identify two stage-specific enhancers: the proximal enhancer mediates the constitutive CCL5 expression during the steady state, while the distal enhancer located 1.35 Mb from the promoter induces CCL5 expression in activated cells. (nature.com)
Here we show that immunization against TERT induces immunity against tumors of unrelated origin. (nova.edu)

When being treated with 2% DMSO in culture medium, Hepa1-6 cells showed depressed proliferation with no significant apoptosis or decreased viability. (oncotarget.com)
D-hep cells, Hepa1-6 cells treated with DMSO for 7 days, could restore to the higher proliferation rate in DMSO-free medium, but alteration of gene expression profile was irreversible. (oncotarget.com)
In particular, B-cell activating factor belonging to the TNF family receptor (BAFF-R), B-cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) play critical roles in promoting B-cell survival at distinct stages of development by engaging a proliferation-inducing ligand (APRIL) and/or BAFF. (nih.gov)
Dysregulated signaling by TNFRSF members can promote B-cell survival and proliferation, causing autoimmunity and neoplasia. (nih.gov)
TSCM are considered as a promising approach in immune cell therapy in cancers due to their high proliferation capacity, longevity and increased survival as well as more potent antitumor effects compared with Tcm and Tem in vivo. (wikipedia.org)
Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
By focusing on the critical roles of different metabolic programs, such as glycolysis, oxidative phosphorylation, fatty acid oxidation, fatty acid synthesis, and amino acid metabolism, as well as their essential regulators in modulating Treg proliferation, migration, and function, we hope to provide new insights into Treg cell-targeted antitumor immunotherapies. (biomedcentral.com)
It is now known that new blood vessels originate from preexisting vessels by activation, proliferation and migration of endothelial cells through a process named "angiogenesis" [ 4 ]. (hindawi.com)
Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
Furthermore, the proliferation of Th17 cells and Th17‑associated cytokines, including interleukin (IL)17, IL23 and RAR‑related orphan receptor γt, was analyzed by reverse transcription‑quantitative polymerase chain reaction. (spandidos-publications.com)
Multiple myeloma (MM) is an incurable cancer in which uncontrolled plasma cell proliferation disrupts the bone marrow environment and impairs immune function. (hrb.ie)
Peripheral blood phenotyping data show increases in CD4+ and CD8+ T cell proliferation two weeks after anti-OX40 administration. (bepress.com)
These data provide evidence that anti-OX40 prior to surgery is safe and can increase activation and proliferation of CD4+ and CD8+ T cells in blood and tumor. (bepress.com)

June 23, 2023 B cells are thought to play a critical role in innate and adaptive immunity, but their exact role in anti-tumor immunity remains unknown. (sciencedaily.com)

Dormant cancer cells: programmed quiescence, senescence, or both? (nature.com)
Cancer Cell 18 , 485-498 (2010). (nature.com)
In addition to its roles in the regulation of inflammatory diseases and the maintenance of local immune cells, CCL5 expressed by cancer cells plays diverse roles in shaping cancer microenvironments toward their own survival. (nature.com)
Other studies reported that some cancer cells could repress their own CCL5 expression to hinder migration of anticancer immune cells toward cancer sites 15 , 16 . (nature.com)
Therefore, host CCL5 can obviously work as an anticancer molecule to mount relevant immune responses against some cancer cells. (nature.com)
Therefore, it might be safe to say that host CCL5 plays important roles in controlling cancer development but might create either pro- or anticancer environments according to the given situation, such as the type of cells that produce CCL5 and the type of cancers. (nature.com)
Photodynamic therapy is a promising approach for cancer treatment that relies on the administration of a photosensitizer followed by tumor illumination. (tcd.ie)
This program will discuss three key areas for the future of cancer immunotherapy: immunity beyond T cells, the application of CAR T therapy in solid tumors, and novel immunotherapy combinations. (sitcancer.org)
1 2 This supports gd T-cells use in cancer immunotherapy. (bmj.com)
In mouse AML and ovarian cancer models, repeated injections of ICT01 delayed tumor growth and significantly prolonged animal survival. (bmj.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
TERT RNA-transfected human DC stimulated TERT-specific CTL in vitro that lysed human tumor cells, including Epstein Barr virus (EBV)-transformed B cells as well as autologous tumor targets from patients with renal and prostate cancer. (nova.edu)
Tumor RNA-transfected DC were used as surrogate targets in the CTL assays, obviating the difficulties in obtaining tumor cells from cancer patients. (nova.edu)
In one instance, where a tumor cell line was successfully established in culture from a patient with renal cancer, the patient's tumor cells were efficiently lysed by the CTL. (nova.edu)
We developed techniques to detect weak T cell responses against HPV, define CD8 and CD4 epitopes and to isolate T cell clones capable of killing cervical cancer cells. (cardiff.ac.uk)
We test T cell responses in a phase I clinical trial of an HPV vaccine in oropharyngeal cancer patients. (cardiff.ac.uk)
We demonstrated that the pro-apoptotic protein Bax can be presented by this pathway in cancer cells (7). (cardiff.ac.uk)
Wang Watts, Lotze MT. Great points arrive in little deals: exosomes, cancer and immunity. (research-in-field.com)
Characterized by the expression of the critical transcription factor forkhead box protein P3, regulatory T (Treg) cells are an essential part of the immune system, with a dual effect on the pathogenesis of autoimmune diseases and cancer. (biomedcentral.com)
Purpose Infusion of interleukin-12 (IL-12) may mediate anti-tumor immunity in animal models yet its Schisantherin B systemic administration to patients with cancer results in minimal Schisantherin B efficacy and severe toxicity. (ecologicalsgardens.com)
Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
Depletion of CD4+CD25+ regulatory T cells enhances natural killer T cell-mediated anti-tumour immunity in a murine mammary breast cancer model. (ox.ac.uk)
Our results imply a potential application of combining T(reg) cell depletion with alpha-GalCer to stimulate NK T cells for cancer therapy. (ox.ac.uk)
Therefore, our work establishes a locoregional treatment strategy for priming cancer stem cell-specific tumoricidal immunity with broad application in patients suffering from recurrent malignancies. (nih.gov)
Interleukin (IL)17-producing Th17 cells, which are different from Th1 and Th2 cells, have been described as serving critical roles in inflammation and autoimmune diseases, as well as in cancer development ( 8 - 11 ). (spandidos-publications.com)
Feb. 16, 2023 Cancer immunotherapy involves using activated T cells to destroy tumors, but it doesn't work for all patients. (sciencedaily.com)
Dec. 21, 2022 Researchers have used artificial DNA to target and kill cancer cells in a completely new way. (sciencedaily.com)
The primary aim of cancer immunotherapy is to enhance immune cells to prevent cancer cells from escaping the immune system's control. (medicalnewstoday.com)
In new research published in the journal Cancer Research , researchers explain how the stress response experienced by T cells can reduce their effectiveness at restricting tumor growth. (medicalnewstoday.com)
When a T cell encounters cancer cells, PERK can react to the stressors, such as lack of glucose, an important nutrient for cells. (medicalnewstoday.com)
However, the researchers in the current study said that this natural T cell response to stress would actually harm the effectiveness of cancer immunotherapy when it comes to stopping tumors. (medicalnewstoday.com)
When T cells are under stress (like when they must fight cancer cells), PERK causes T cells to stop secreting proteins in order to protect and help the T cell survive. (medicalnewstoday.com)
A team of researchers led by the University of California San Diego has created a device that measures how 'sticky' cancer cells are, which could improve prognostic evaluation of patient tumors. (news-medical.net)
Their work addresses a longstanding problem in the field of cancer research: it has been difficult to find biological markers to universally identify and select the most aggressive cells in tumors. (news-medical.net)
Cancer cells are placed in the chamber and after they adhere, a fluid is pushed through to detach cells. (news-medical.net)
Comparing this signature to thousands of patients in the Cancer Genome Atlas (TCGA) database, researchers found that patients with tumors high in this 'weakly adherent signature' experienced tumor recurrence occurred earlier and more frequently. (news-medical.net)
If our mouse model shows that these cells indeed reduce cancer-free survival times, it will pave the way for substantial prognostic studies in humans with these types of solid tumors,' said first author Pranjali Beri, a bioengineering Ph.D. student in Engler's lab. (news-medical.net)
Immune checkpoint inhibitors that activate T cells to target cancer cells have greatly improved patient outcomes across a variety of tumor types. (medicalxpress.com)
A therapy that uses a virus to kill tumor cells can be safely given to children with a rare, incurable form of brain cancer, an early study has found. (medicalxpress.com)
Interestingly, P-Tex cells expressed CDK4 genes as high as cancer cells, which could be simultaneously inhibited by CDK4 inhibitors and might be a potential reason for the ineffectiveness of CDK4 inhibitors in treating HPV-positive HNSCC. (elifesciences.org)
The compelling conclusion that proliferative exhausted T cells are associated with response in HPV+ head and neck cancer is supported by the cohort of 14 patients with paired tumor and adjacent normal tissue and rigorous bioinformatic analysis of nearly 50,000 single CD3+ T cell transcriptomes. (elifesciences.org)
The TME, however, can be metabolically hostile due to insufficient vascular exchange and cancer cell metabolism that leads to hypoxia, depletion of nutrients, and accumulation of waste products. (elifesciences.org)
Expanded understanding of the basic biology of T cell activation has enabled immunotherapy to combat cancer, and T cell metabolism now offers the opportunity to optimize and improve these therapeutic strategies. (elifesciences.org)
This diverging evidence suggests effective translation into clinical practice of information on cancer cell metabolism acquired by decades of basic research. (cambridge.org)
The likelihood of a patient responding to immune checkpoint blockade may depend on B cells in the tumor, located within specialized immune-cell clusters known as tertiary lymphoid structures (TLS), according to researchers at The University of Texas MD Anderson Cancer Center . (mdanderson.org)
These findings open up a whole new area ― that B cells are actually big drivers in cancer immunotherapy, specifically checkpoint blockade," said corresponding author Jennifer Wargo, M.D. , professor of Genomic Medicine and Surgical Oncology . (mdanderson.org)
Decreased antigen presentation contributes to the ability of cancer cells to evade the immune system. (lu.se)
We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). (lu.se)
Reprogramming cancer cells to antigen-presenting cells. (lu.se)
SCR-6852, an oral and highly brain-penetrating estrogen receptor degrader (SERD), effectively shrinks tumors both in intracranial and subcutaneous ER + breast cancer models. (medscape.com)
miR-203 drives breast cancer cell differentiation. (medscape.com)
Correction: Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy. (medscape.com)
IPA analysis of the 280 significantly differentially expressed genes in the whole blood was suggestive of increased hematopoiesis and cell development, activation of cancer/tumor development pathways, and atopy. (cdc.gov)
Her research involves direct reprogramming approaches, which function like a Trojan horse, enabling cancer cells to be targeted by the immune system. (lu.se)
Immunotherapy can fail in patients with cancer when certain cancer cells can hide from the immune system. (lu.se)
We focused particularly on harnessing reprogramming, or direct cellular reprogramming, to induce antigen presentation in cancer cells. (lu.se)
However, cDC1 can be compromised in cancer patients and some cancer cells lack these antigen-presenting proteins on their surface, impacting immunotherapy response. (lu.se)
Direct reprogramming strategies with cDC1-specific factors can induce antigen-presentation in cancer cells, making cancer cells visible to the immune system and easier to fight. (lu.se)
Animal studies have shown that LAK cells are more effective against cancer cells than are the original endogenous T cells, presumably because of their greater number. (msdmanuals.com)
Therefore CAR T cells and TCR T cells may represent complementary approaches to cancer therapy. (msdmanuals.com)
CAR T cell immunotherapy for human cancer. (msdmanuals.com)
Budget Impact Analysis of Comprehensive Genomic Profiling in Advanced Non-Small Cell Lung Cancer in Taiwan. (cdc.gov)
Cost-Effectiveness of Next-Generation Sequencing Versus Single-Gene Testing for the Molecular Diagnosis of Patients With Metastatic Non-Small-Cell Lung Cancer From the Perspective of Spanish Reference Centers. (cdc.gov)
This project will aim to test a cancer immunotherapy approach based on in-vivo dendritic cell reprogramming of tumor cells to reinstate anti-tumor immunity. (lu.se)
Documented knowledge in tumor immunology, with practical experience in in-vivo evaluation of cancer immunotherapies using mouse syngeneic mouse models. (lu.se)
Purpose Treating solid tumors with cancer immunotherapy (CIT) can result in unconventional responses and overall survival (OS) benefits that are not adequately captured by Response Evaluation Criteria In Solid Tumors (RECIST) v1.1. (medscape.com)

Because tumour dormancy provides a unique therapeutic window to prevent metastatic disease, we discuss on-going clinical trials and weigh the potential for immunotherapy to eradicate dormant disease. (nature.com)
This study may provide a much-needed physical marker that identifies highly metastatic cells within a heterogeneous tumor cell population. (news-medical.net)
2020) Cell adhesiveness serves as a biophysical marker for metastatic potential. (news-medical.net)
At diagnosis half of the patients have a metastatic tumour and recurrence is very common. (hrb.ie)
Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA. (medscape.com)

BTN3A, which belongs to the B7-subfamily of Ig proteins, is required for the recognition of malignant or infected cells by human g9d2 T-cells by sensing intracellular accumulation of phosphoantigens. (bmj.com)

The worldwide diary of biochemistry and biology & cell biology. (research-in-field.com)
BMC Cell Biology, 9 , 45. (springer.com)
This is an article of high relevance for T cell biology and T cell therapy in general," she said. (medicalnewstoday.com)
Experience in dendritic cell biology and antigen presentation mechanisms is a merit, T cell biology is also attractive. (lu.se)

Actinium believes Actimab-A has the potential to be used in combination with immunotherapy, including immune checkpoint inhibitors, to enhance antitumor immunity via targeted MDSC depletion. (actiniumpharma.com)
Antitumor immunity elicited by tumor-APCs was synergistic with immune checkpoint inhibitors. (lu.se)
Increasing age and decreasing cell-mediated immunity as a result of transplantation, chemotherapy, or other immunosuppressive medications (e.g., tumor necrosis factor-α inhibitors) are the main predisposing factors ( 1 , 2 , 9 ). (cdc.gov)

Rosa et al, Science Immunology 2022 ) and has shown recently that the same combination of factors can reprogram tumor cells into antigen presenting cells (Zimmermannova et al, In revision). (lu.se)
PhD in immunology, immune-oncology, tumor immunology, or similar, recently graduated or with less than 3 years of post-graduation experience in academic or industrial environment. (lu.se)

These studies indicate that further understanding the metabolic requirements of intratumoral Tregs may provide an opportunity to intervene in the immunosuppressive TME and enhance antitumor immunity. (biomedcentral.com)
iNKT cells can promote the polarization of adaptive immune responses towards both Th1 and Th2 and can secrete immunosuppressive cytokines [ 19 ]. (biomedcentral.com)
Tumors can have an immunosuppressive environment comprised of multiple cell types including those of myeloid origin. (ecologicalsgardens.com)
Furthermore, we describe a subset of myeloid cells with immunosuppressive activity (known as myeloid-derived suppressor cells). (hindawi.com)

Restoring antitumor immunity with dendritic cell reprogramming strategies. (lu.se)
Alexandra Gabriela Barros Ferreira defends her Ph.D. thesis "Restoring antitumor immunity with dendritic cell reprogramming strategies" on Friday, 17 November, 2023. (lu.se)
My Ph.D. studies have focused on restoring anti-tumor immunity with dendritic cell reprogramming strategies. (lu.se)

Infiltration of tumours with CD8+ T cells with a resident memory (Trm) phenotype correlates with improved survival. (cun.es)
Anti-PD-1 treatment promotes infiltration of transferred Tcm cells within tumours, improving anti-tumour immunity. (cun.es)

Members of the tumor necrosis factor receptor superfamily (TNFRSF) participate prominently in B-cell maturation and function. (nih.gov)
Characterization of the receptor for the transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), encoded by the gene TNFRSF13B ( tumor necrosis factor receptor superfamily member 13B), suggests that people with the C104, A181E, and ins204A variants may be at risk for IgAD that progresses to CVID. (medscape.com)

When assayed in human and cynomolgus PBMCs in vitro, ICT01 promoted a robust and specific activation of g9d2 T-cells as shown by concentration dependent increase in cell surface CD69 and CD25 and cytokines secretion (IFNγ, TNFα). (bmj.com)
IL-12 and IL-23 are pro-inflammatory cytokines that are important to the development of T helper 1 (Th-1) and T helper 17 (Th-17) T cell subsets while IL-27 and IL-35 are potent inhibitory cytokines[6]. (ecologicalsgardens.com)
In a tumour setting, NK T cells activated by alpha-galactosylceramide (alpha-GalCer) execute anti-tumour activity by secreting cytokines. (ox.ac.uk)
The present study investigated the expression of T helper (Th)17 cytokines in patients with laryngeal squamous cell carcinoma (LSCC) and their clinical significance in providing new therapeutic insights. (spandidos-publications.com)
For immunotherapy to be effective, T cells must secrete cytokines, such as cytotoxic cytokines to kill tumor cells. (medicalnewstoday.com)
A previous study demonstrated that the activation of CD4+ T cells (Th1) by influenza vaccination leads to the secretion of Th1-type cytokines (e.g., interferon-γ) ( 10 ), which activates macrophage phagocytosis and may subsequently kill intracellular M. tuberculosis . (cdc.gov)

Conclusions The combined in vitro and in vivo pharmacology data provide evidence that ICT01 is an attractive and novel therapeutic approach for enhancing the innate anti-tumor potential of g9d2 T-cells by activating BTN3A. (bmj.com)
Our research proposed viable tumor cells with altered biological features by DMSO-treatment could induce anti-tumor immunity in vivo . (oncotarget.com)
In contrast, ACT expands a patient's own T cells ex vivo to direct anti-tumor immunity when transfused back into the patient. (elifesciences.org)
In addition to acquiring improved antigen presentation, tumor-APCs had impaired tumorigenicity in vitro and in vivo. (lu.se)

However, it remains unknown how T¿RII are regulated in myeloid cells during tumor progression. (nih.gov)

In this review, we present a current understanding of the functions of and distinctions between APRIL/BAFF signaling by their respective receptors expressed on particular B-cell subsets. (nih.gov)
Although initially identified by co-expression of conventional αβ T-cell receptors (TCR) and markers typically associated with natural killer (NK) cells [ 3 ], NKT are currently distinguished on the basis of CD1d restriction as well as specific usage of TCRα chains [ 4 ]. (biomedcentral.com)
The prevalence of Th17 cells and their receptors in patients with LSCC was studied using immunohistochemical analysis via tissue microarray technology. (spandidos-publications.com)
Further, inhibitory receptors present in the TME can inhibit T cell metabolism and alter T cell signaling both directly and through release of extracellular vesicles such as exosomes. (elifesciences.org)
Chimeric antigen receptors (CAR) recognize specific proteins on the surface of tumor cells. (msdmanuals.com)

Longitudinal studies on TSCM dynamics in patients undergoing hematopoietic stem cell transplantation (HSCT) have shown that donor-derived TSCM cells were highly enriched early after HSCT, differentiated directly from Tn, and that Tn and TSCM cells (but not central memory or effector T cells) were able to reconstitute the entire heterogeneity of memory T cell subsets including TSCM cells. (wikipedia.org)
Together with the transcriptome analysis of differentially expressed genes reflecting the relatedness of TSCM and Tn cells, these data support the existing hierarchical model of human T cell differentiation: naïve T cells (Tn) → stem cell like memory T cells (T scm) → central memory T cells (Tcm) → effector memory T cells (Tem) / effector T cells (Teff). (wikipedia.org)

Sandesh Seth, Actinium's Chairman and CEO, commented, "These data further increase our enthusiasm for Actimab-A's potential in solid tumor indications. (actiniumpharma.com)
Immunotherapy has had a profound impact on patient outcomes across multiple solid tumor indications, however, there are still several indications with high unmet needs and significant room to further improve patient outcomes. (actiniumpharma.com)
Beri also noted that nearly any solid tumor should exhibit this physical marker, and the team has so far tested cells from breast, prostate, and lung tumors. (news-medical.net)

Assessment of tumor-infiltrating TCRVγ9Vδ2 γδ lymphocyte abundance by deconvolution of human cancers microarrays. (bmj.com)
The secondary objective was to assess the effect of anti-OX40 on lymphocyte subsets in the tumor and blood. (bepress.com)
It provides immunity to the body from bacteria, viruses, parasites, and tumors by producing B lymphocyteand T lymphocyte cells). (cdc.gov)
Perspectives of tumor-infiltrating lymphocyte treatment in solid tumors. (msdmanuals.com)
Although antilymphocyte serum was used in the treatment of chronic lymphocytic leukemia and in T-cell and B-cell lymphomas, resulting in temporary decreases in lymphocyte counts or lymph node size, newer humoral immunotherapeutic modalities have been developed. (msdmanuals.com)
Tests that demonstrate the status of cellular immunity include lymphocyte numbers (i.e., a complete blood count with differential), a test that delineates concentrations and proportions of lymphocyte subsets (i.e. (cdc.gov)

Relationship between hematogenous tumor cell dissemination and cellular immunity in DCIS patients. (nature.com)
Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset. (bmj.com)
As a necrotic cell death, the rupture of cell plasma membrane of necroptotic cells results in the release of many cellular factors of necroptotic cells, which may trigger inflammation and immune responses [ 17 , 18 ]. (biomedcentral.com)
Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
In passive cellular immunotherapy, specific effector cells are directly infused and are not induced within the patient. (msdmanuals.com)
Passive cellular immunotherapy references A number of immunologic interventions, both passive and active, can be directed against tumor cells. (msdmanuals.com)
In passive cellular immunotherapy, specific effector cells. (msdmanuals.com)
Primary immunodeficiencies generally are inherited and include conditions defined by an inherent absence or quantitative deficiency of cellular, humoral, or both components that provide immunity. (cdc.gov)
Primary and secondary immunodeficiencies might include a combination of deficits in both cellular and humoral immunity. (cdc.gov)

By depleting MDSCs in a targeted manner, we are excited by the prospect of Actimab-A synergizing with immunotherapy to enhance antitumor immunity. (actiniumpharma.com)

This new device could be the first step to better assess how likely tumor recurrence is. (news-medical.net)

P-Tex cells could aggregate in the antigen-presenting cell niches and activate certain signaling pathways. (elifesciences.org)
T cells must substantially increase nutrient uptake to mount a proper immune response and failure to obtain sufficient nutrients or engage the appropriate metabolic pathways can alter or prevent effector T cell differentiation and function. (elifesciences.org)

ICT01-mediated killing activity of g9d2 T-cells was assessed using in vitro co-cultures with tumor and non-tumor cells. (bmj.com)
Lv LH, Wan YL, Lin Y, Zhang Watts, Yang Meters, Li GL, Lin HM, Shang CZ, Chen Orientin IC50 YJ, Minutes M. Anticancer medicines trigger launch of exosomes with warmth surprise Orientin IC50 protein from individual hepatocellular carcinoma cells that elicit effective organic murderer cell antitumor replies in vitro . (research-in-field.com)
Subsequent studies described a VEGFR2 and AC133 expressing subpopulation of these CD34 positive circulating cells that could form endothelial colonies in vitro [ 14 , 15 ]. (hindawi.com)
In this study, we have shown that T(regs) regulate NK T cell function negatively in vitro, suggesting a direct interaction between these cell types. (ox.ac.uk)

Two of the primary immunotherapies are immune checkpoint blockade (ICB) and adoptive cell transfer (ACT). (elifesciences.org)
The current studies conclude that the presence of B cells and their location within TLS, which act as a lymph node within the tumor, is critical for response to checkpoint blockade, suggesting a dynamic interaction between several components of the immune system. (mdanderson.org)
In each cohort, the expression of B cell-related genes was significantly higher in responders and was predictive of response to checkpoint blockade. (mdanderson.org)

Dutta A, Banerjee A, Saikia In, Phookan M, Baruah MN, Baruah H. Unfavorable rules of organic monster cell in growth cells and peripheral bloodstream of dental squamous cell carcinoma. (research-in-field.com)
In this review, we discuss the common and distinct metabolic profiles of Tregs in peripheral tissues and the TME, as well as the differences between Tregs and other conventional T cells in their metabolic preferences. (biomedcentral.com)
13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)
Flow cytometry was used to investigate the percentage of Th17 and Th1 cells in peripheral blood mononuclear cells. (spandidos-publications.com)
The results revealed that the prevalence of Th17 cells in patients with LSCC was elevated in their primary tumors, as well as in peripheral blood, compared with that in healthy controls. (spandidos-publications.com)
The present study revealed that patients with LSCC have elevated levels of Th17 cells in their primary tumors and peripheral blood compared with those in healthy controls. (spandidos-publications.com)

Both tumor cells and the T cells present in the tumor need glucose in order to thrive and they compete for this nutrient. (medicalnewstoday.com)

Murine mammary carcinoma exosomes promote growth development by reductions of NK cell function. (research-in-field.com)
Growth and endothelial cell-derived microvesicles bring unique CEACAMs. (research-in-field.com)
In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)
Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
They said that by manipulating various proteins in the stress response pathway within T cells, it is possible to overcome the T cell's intrinsic stress response and enable the immune system to fight against further tumor growth. (medicalnewstoday.com)
Previous studies have shown that T cells without PERK were better at controlling tumor growth when transfused into tumor-bearing hosts. (medicalnewstoday.com)

Actinium's technology platform is the basis for collaborations with Astellas Pharma and AVEO Oncology/LG Chem Life Sciences for solid tumors. (actiniumpharma.com)

However, many patients fail to respond to these therapies, and metabolic barriers imposed on T cells by the TME may contribute. (elifesciences.org)
Clinical trials of LAK cells in humans are ongoing but this approach has not gained widespread use and is generally considered less effective than other cell therapies. (msdmanuals.com)

Here we describe a novel mechanism of tumor immune escape mediated by iNKT cells that limit priming of anti-tumor T cells by controlling DC in tumors and draining lymph nodes. (biomedcentral.com)

On the one hand, tumor cells are under immunosurveillance in the presence of various proinflammatory cells, such as CD8 + cytotoxic T cells, CD4 + type 1 helper T (Th1) cells, and natural killer cells. (biomedcentral.com)
T-cell engagers are bispecific antibodies that recruit cytotoxic T cells to kill tumor cells. (msdmanuals.com)
CD4 cytotoxic T cells: an emerging effector arm of anti-tumor immunity. (cdc.gov)

The prognostic landscape of genes and infiltrating immune cells across human cancers. (bmj.com)
Also, the genes that identify these weakly adherent cells make patients' tumors five times more likely to reoccur within five years. (news-medical.net)
An MD Anderson-led study found that B-cell markers were the most differentially expressed genes in responders relative to non-responders, and B cells in the tumors of responders appeared to be more mature and specialized. (mdanderson.org)

The innate immune system is mainly composed of myeloid lineage cells, such as macrophages, neutrophils, and mast cells [ 2 ]. (hindawi.com)
Specific helper T cells are able to activate macrophages to form the granulomas that are characteristic of the disease. (medscape.com)

3 ImCheck Therapeutics is developing ICT01, a humanized anti-BTN3A (IgG1, Fc-silenced), g9d2 T-cell-activating antibody for the treatment of patients with solid or hematologic tumors. (bmj.com)
The effects of antibody-mediated blockade of CD1d on DC number and phenotype, priming of anti-tumor T cells, and tumor response to treatment with local radiotherapy and anti-CTLA-4 antibody were evaluated. (biomedcentral.com)
In an orthotopic patient-derived glioblastoma humanized mouse model, the combined treatment with nanoporter-hydrogel superstructure and CD47 antibody increased the frequency of positive immune responding cells and suppressed the negative immune regulating cells, conferring a robust tumoricidal immunity surrounding the postsurgical cavity and inhibiting postoperative glioblastoma relapse. (nih.gov)
Here we describe the results from a phase Ib clinical trial (NCT02274155) in which 17 patients with locally advanced head and neck squamous cell carcinoma (HNSCC) received a murine anti-human OX40 agonist antibody (MEDI6469) prior to definitive surgical resection. (bepress.com)
Tests useful to assess humoral immunity include immunoglobulin (and immunoglobulin subset) levels and specific antibody levels (e.g., tetanus and diphtheria). (cdc.gov)

The generated oxidative stress may activate multiple mechanism of cell death which are counteracted by adaptive stress responses that target homeostasis rescue. (tcd.ie)
Analysis of lung tissue RNA using Ingenuity Pathway Analysis (IPA) indicated trends in inflammatory response and connective tissue organization markers, with an emphasis on immune cell trafficking, phagocytosis, and adaptive immune responses. (cdc.gov)

Interestingly, systemic delivery of miR130a and miR145 improved anti-tumor immunity and efficacy of paclitaxel treatment. (nih.gov)
Using different vaccination strategies that fine-tune the generation of Trm cells or circulating memory T cells, here we show that, while both subsets are sufficient for anti-tumour immunity, the presence of Trm cells improves anti-tumour efficacy. (cun.es)
We also discuss the mechanisms underlying Treg functional fitness in the TME, hoping to find potential approaches to reestablish proinflammatory circumstances by perturbing these metabolic programs, ultimately enhancing the efficacy of antitumor immunity. (biomedcentral.com)
T cell metabolism has already been shown to influence T cell therapy efficacy in the clinical setting. (medicalnewstoday.com)
Response Evaluation Criteria In Solid Tumors (RECIST) v1.1 end points, originally developed to evaluate the benefit of chemotherapeutic and targeted agents, are accepted measures of clinical efficacy in advanced solid malignancies. (medscape.com)

Another interest of the group is the definition of immune signatures based on immune cell phenotype and function, as prognostic markers. (cardiff.ac.uk)

Preclinical studies in murine tumor treatment models demonstrated powerful antitumor effects following the systemic administration of IL-12[7]. (ecologicalsgardens.com)
8] To improve ACT using TIL and to take advantage of the antitumor properties of IL-12 we as well as others used genetic engineering of anti-tumor T cells with a gene encoding IL-12 to deliver the potent cytokine selectively to the tumor site in murine tumor models[9-12]. (ecologicalsgardens.com)
In preclinical studies the transduction of murine anti-tumor T cells with a gamma-retrovirus encoding IL-12 substantially increased the ability of low numbers of cells to mediate the destruction of invasive cancers in the absence of IL-2 administration. (ecologicalsgardens.com)
Antigen reactive murine T cells constructed with this NFAT governed IL-12 vector (NFAT.IL-12) effectively treated huge established murine tumors in cell dosages that had minimal undesireable effects and in. (ecologicalsgardens.com)

CCL5 is a unique chemokine with distinct stage and cell-type specificities for regulating inflammation, but how these specificities are achieved and how CCL5 modulates immune responses is not well understood. (nature.com)
[ 6-8 ] This may be due to anticancer immune activity leading to tumor inflammation or the dynamic nature of immunity, which may depend on tumor, host, or environmental factors. (medscape.com)

Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. (nature.com)
We initially determined that miRs 130 and 145 can directly target Tgfbr2 mRNA by mouse miRNA expression assay, and were down-regulated in Gr1+CD11b+ myeloid cells from 4T1 or Eo771 mammary tumor model. (nih.gov)

Reprogramming restored the expression of antigen presentation complexes and costimulatory molecules on the surfaces of tumor cells, allowing the. (lu.se)

It also revealed that in type I diabetes patients there was an enrichment of self-reactive clonotypes in TSCM rather than in Tm, suggesting that TSCM might serve as a pool of autoreactive T cells. (wikipedia.org)
By contrast, T(regs) intrinsically suppress antigen-specific immune responses and are often found to be elevated in tumour patients. (ox.ac.uk)
Almost all patients with GBM relapse within a narrow margin around the initial resected lesion due to postsurgery residual glioma stem cells (GSCs). (nih.gov)
A total of 70 tumors and 70 adjacent control tissues (pathologically confirmed normal mucosa) were obtained from patients with LSCC undergoing surgery. (spandidos-publications.com)
A robust metabolic function of T cells is found in patients with better clinical response. (medicalnewstoday.com)
Patients with few of these aggressive cells lying dormant in their surrounding tissue may be less likely to see a tumor reoccur 5, 10, or 20 years later. (news-medical.net)
A proliferative exhausted CD8 + T cell cluster (P-Tex) which was beneficial to survival outcomes of patients with HPV-positive HNSCC was identified. (elifesciences.org)
Together, our findings suggest a promising role for P-Tex cells in the prognosis of patients with HPV-positive HNSCC by providing modest but persistent anti-tumor effects. (elifesciences.org)
Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. (bepress.com)
Analyses of CD8+ TIL show increases in tumor-antigen reactive, proliferating CD103+ CD39+ cells in 25% of patients with evaluable tumor tissue (N = 4/16), all of whom remain disease-free. (bepress.com)
Tumor samples were collected from patients at baseline and during treatment through the APOLLO platform , and detailed immune profiling was completed in part by the immunotherapy platform , both part of the Moon Shots Program. (mdanderson.org)
ABSTRACT To test the role of T helper cell Th1 immunity we recruited 24 patients with idiopathic thrombocytopenia associated with H. pylori seropositivity. (who.int)
Ils ont été répartis en deux groupes : 12 patients souffrant d'une thrombocytopénie à médiation immunitaire (groupe 1) et 12 patients atteints d'une thrombocytopénie à médiation non immunitaire (groupe 2). (who.int)
therefore, IgA-poor blood or washed red cells are preferred for those patients. (medscape.com)
These patterns include an initial transient increase in tumor burden before response [ 4 , 5 ] and/or appearance of new lesions (NLs) in patients with responding baseline lesions. (medscape.com)

Natural killer cells mediate extracellular killing, which antibodies enhance. (medscape.com)
The most frequently used engagers are antibodies targeting one tumor antigen and one molecule on T cells (mostly CD3). (msdmanuals.com)

The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) is largely different, and little is known about the anti-tumor mechanism of tumor-infiltrated exhausted CD8 + T cells (Tex) in HNSCC. (elifesciences.org)

Anatomy31

Organisms22

Diseases39

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes50

Disciplines and Occupations1

Information Science3

Health Care3

Microenvironment18

Lymphocytes17

Metastasis28

Antigens12

Melanoma7

Mice12

Induces2

Proliferation13

Innate and adaptive immunity1

Cancer66

Metastatic5

Malignant1

Biology4

Inhibitors3

Immunology2

Immunosuppressive4

Dendritic cell3

Infiltration2

Necrosis factor receptor superfamily2

Cytokines6

Vivo4

Progression1

Receptors5

Effector T cel2

Solid tumor3

Lymphocyte6

Cellular9

Enhance antitumor immunity1

Recurrence1

Pathways2

Vitro4

Checkpoint3

Peripheral6

Present in the tumor1

Growth6

Oncology1

Therapies2

Novel mechanism of tumor1

Cytotoxic T cel3

Genes3

Macrophages2

Antibody5

Adaptive2

Efficacy5

Immune cell1

Murine4

Inflammation2

Mammary2

Antigen presentation1

Patients15

Antibodies2

Squamous cell carc1