Tumor suppressor protein p53 growth of tumor cells cell cycle. Medical search. Frequent questions

Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. (lsbio.com)
In the context of aberrant growth control, many important genes responsible for the genesis of various cancers have been discovered and the pathways through which they act characterized. (bioinf.org)
p53 is a master gene regulator controlling diverse cellular pathways, by either activating or repressing downstream genes. (bioinf.org)
In addition, cells can produce more than 300 different protein variants from AARS genes through alternative splicing of their mRNAs or post-translational protein fragmentation. (fascea.pics)
Somatic mutations in other genes involved in cell growth are also needed for a melanoma to develop. (medlineplus.gov)
Transcriptomic studies of L. trifolii indicated significant enrichment of differentially expressed genes (DEGs) in 'post-translational modification, protein turnover, chaperones', 'sensory perception of pain/transcription repressor complex/zinc ion binding' and 'insulin signaling pathway' when analyzed with the Clusters of Orthologous Groups, Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes databases, respectively. (bvsalud.org)
Interestingly, there was no significant difference in the expression of genes encoding heat shock proteins or antioxidant enzymes in L. trifolii treated with microwave radiation as compared to the untreated control. (bvsalud.org)
The pathophysiology of epidermodysplasia verruciformis is linked to defective cell-mediated immunity, with elucidation of mutations in EVER1 ( TMC6 ) and EVER2 ( TMC8 ) genes (band 17q25). (medscape.com)
Several genetic alterations have been described in SCCHN, including mutations in the p53 tumor suppressor gene and mutations in genes that encode cell cycle proteins such as p16 and cyclin D1. (oncotarget.com)
The viral genome maintains itself as an episome in basal cells, where the viral genes are poorly expressed. (ghise-ioan.ro)
Initiation and propagation of tumors reflect underlying genomic alterations such as mutations, polymorphisms, and copy number variations found in genes of multiple cellular pathways. (hindawi.com)
Nowell, a tumor biologist in the pathology department at the University of Pennsylvania School of Medicine, was interested in the relationship between cancer and alterations in genes (although he had no proof there was one). (laskerfoundation.org)
We investigated by real-time quantitative RT-PCR the expression profile of a panel of genes important in cell cycle regulation. (biomedcentral.com)
Interestingly, the 1p36 region is frequently deleted not only in NB, but also in other human cancer types, including those of neural, epithelial and hematopoietic origin, indicating that the same tumor suppressor genes might be involved in a broad range of human cancers [ 11 ]. (biomedcentral.com)
The tumor suppressor TP53 (also called p53) has been among the most extensively studied genes since its discovery in 1979 [ 1 , 2 ]. (nature.com)
To achieve this, p53 mainly functions as a transcription factor (TF) targeting hundreds of genes, but it also has TF-independent roles in the nucleus and cytoplasm [ 6 ]. (nature.com)
Only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. (sdbonline.org)
SIRT1 is localized in the nucleus and can deacetylate numerous proteins such as tumor suppressor protein (p53), Ku70, NF-κB, and forkhead proteins which modulate genes that control cellular stress resistance ( Smith, 2002 ). (frontiersin.org)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

About 8% of cases are hereditary, and approximately half of these are associated with germline mutations of the breast tumor suppressor gene BRCA1 (refs. (nih.gov)
p53 mutations in human cancers. (lsbio.com)
While mutations in p53 occur in less than 10% of acute myeloid leukaemia (AML), over-expression of the main negative regulator of p53, MDM2, is frequently observed, representing a mechanism of p53 silencing. (uib.no)
References 2 and 3 describe the characteristics of cancer cells and the importance of mutations in cancer development. (nature.com)
Mutations in the CDKN2A gene are found in up to one-quarter of head and neck squamous cell carcinomas (HNSCC). (medlineplus.gov)
Most of these mutations lead to production of little or no functional p16(INK4A) protein. (medlineplus.gov)
Mutations in the CDKN2A gene are also associated with melanoma, a type of skin cancer that begins in pigment-producing cells called melanocytes. (medlineplus.gov)
These mutations, classified as germline mutations, are typically inherited and are present in essentially all of the body's cells. (medlineplus.gov)
The CDKN2A gene mutations found in melanoma result in a nonfunctional p16(INK4A) protein. (medlineplus.gov)
Together, the germline and somatic mutations impair the function of proteins that regulate division and senescence, leading to uncontrolled cell growth and the formation of a melanoma. (medlineplus.gov)
CDKN2A gene mutations involved in cancer impair production of functional p16(INK4A) or, less commonly, p14(ARF), which can result in uncontrolled cell growth and tumor formation. (medlineplus.gov)
Cancer is a disease caused by the unrestrained growth of tumor cells in the body that are thought to be summoned by mutations in the cells. (lidsen.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Mutations of p53 occur at a frequency of 50% or higher in many different cancer types [ 13 ]. (biomedcentral.com)
In this paper, we ask the following questions: How do these proteins and their mutations change the cell's fate - apoptosis or survival - when HMGB1 signal transduction is activated? (biomedcentral.com)
Expression of p63 is almost exclusively restricted to epithelial cells, mutations in this gene are infrequent, and its expression is increased in a variety of solid tumors, particularly those of the head and neck area 12,13 . (bvsalud.org)

The p53 protein is an important tumor suppressor that is essential for regulating cell division, senescence, and self-destruction (apoptosis). (medlineplus.gov)
The protein p53 is one of the most important tumor suppressor proteins: its activation can lead to cell cycle arrest, DNA repair, or apoptosis. (biomedcentral.com)
p53, the guardian of the genome, is the most important tumor suppressor. (oncotarget.com)

Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene. (wikipedia.org)
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. (wikipedia.org)
Dr. Buolamwini, professor and chair of pharmaceutical sciences in the College of Pharmacy, worked with an interdisciplinary team of scientists in discovering a new class of small molecule inhibitors of the rogue, cancer-causing protein MDM2, which opposes the effects of the famous tumor suppressor p53, a gene that is thought to regulate the cell cycle and stop damaged cells from dividing. (rosalindfranklin.edu)
The CDKN2A gene provides instructions for making several proteins. (medlineplus.gov)
A different type of alteration involving the CDKN2A gene can result in reduced amounts or an absence of the p16(INK4A) or p14(ARF) protein. (medlineplus.gov)
In 2012, two siblings who were homozygous for a mutation that created a stop codon in the Ras homolog gene family member H ( RHOH ) gene exhibited an epidermodysplasia verruciformis phenotype and their T cells exhibited impaired T-cell receptor (TCR) signaling. (medscape.com)
Consideration of tumor heterogeneity is therefore important in the critical analysis of gene associations in cancer. (hindawi.com)
The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. (cancerindex.org)
This gene is regarded as a potential tumor suppressor gene. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
The relationship between the expression of p53, Bcl-2 Associated X-protein and MicroRNA-16-5p was studied by dual-luciferase gene assay, Quantitative Reverse transcription- polymerase chain reaction, and Western blotting. (ijpsonline.com)
The results of Quantitative Reverse transcription- polymerase chain reaction and Western blotting showed that the target gene of MicroRNA-16-5p was p53, and the over expression of MicroRNA-16-5p could promote the expression of p53 and Bcl-2 Associated X-protein, which was positively correlated. (ijpsonline.com)
The number of encoded NBPF/DUF1220 repeats varies from 4 to 52 copies, depending on the gene member and the NBPF1 protein has 7 repeats [ 6 ]. (biomedcentral.com)
Taken all together this demonstrates a role for Buffy, a Bcl-2 pro-cell survival gene, in neuroprotection. (sdbonline.org)
The p73 gene encodes more than 20 protein isoforms due to the usage of different promoters and on the other hand post-transcriptional splicing. (igesip.org)
Numerous cellular proteins detect DNA damage and induce senescence , a permanent change of state characterized by morphological and gene expression changes. (massgenomics.org)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)

Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. (lsbio.com)
All somatic cells proliferate via a mitotic process determined by progression through the cell cycle. (bioinf.org)
However, binding of p16(INK4A) blocks CDK4's or CDK6's ability to stimulate cell cycle progression. (medlineplus.gov)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (cancerindex.org)
Effects of circPAPD4 overexpression on tumor progression were investigated using in vivo assays. (biomedcentral.com)
Importantly, circRNAs usually bind miRNAs to modulate the levels of downstream proteins, acting as competing endogenous RNA (ceRNA) and participating in tumor progression [ 11 ]. (biomedcentral.com)
For instance, the biogenesis of circRNA GGNBP2 (cGGNBP2) was mediated by IL-6/STAT3 pathway activation, and IL-6/cGGNBP2-184aa (a protein encoded by cGGNBP2)/STAT3 formed a positive feedback loop to promote tumor progression for intrahepatic cholangiocarcinoma. (biomedcentral.com)
MicroRNA-16-5p was a tumor suppressor in the progression of glioma. (ijpsonline.com)
While some patients experience spontaneous regression or differentiation of the tumor, others are affected by rapid and fatal tumor progression despite increasingly intensive treatment strategies [ 9 ]. (biomedcentral.com)
In addition to its role in controlling cell cycle progression, the tumor suppressor protein p53 can also affect other cellular functions such as cell migration. (rupress.org)
Conclusion: p63, p16, MIB, Cal A, Cys A are markedly expressed and p16 is strongly suppressed in oral cavity tumors, which suggests that the latter protein may play a role in negative regulation of cell cycle progression. (bvsalud.org)
Immunohistochemical identification of molecular genetic events in the progression of preneoplastic lesions to spindle cell squamous-cell carcinoma enables early detection of lesions with the potential for malignant progression, thus permitting timely intervention 1,2 . (bvsalud.org)
The various markers that enable assessment of the progression of preneoplastic lesions to spindle cell carcinoma include the p16 protein, which halts the cell cycle and induces apoptosis by pRb-mediated phosphorylation of cyclin-dependent kinase 4 (CDK4). (bvsalud.org)

Primarily, p53 protects the cell from malignant transformation through cell cycle arrest and apoptosis. (uib.no)
HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. (asspub.ro)
Malignant skin tumors (carcinomas), especially squamous cell carcinoma (in situ or invasive), develop frequently in these patients (30-70%), most commonly in sun-exposed areas starting between the ages of 20 and 40 years, which reflects the high-risk nature of the HPV infection. (medscape.com)
Glioma was one of the most common malignant brain tumors. (ijpsonline.com)
MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)
[ 4 , 5 ] ) Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)

This leads to activation of p53 and the p53 pathway in cancer cells with wild type p53, subsequently inhibiting tumour growth. (uib.no)
Nutlin-3 and VPA in combination was found to show a synergistic effect in vitro in an AML cell line expressing wild type p53 (MOLM-13). (uib.no)
Outcomes TAp73 enhances mobile awareness to cisplatin in ovarian cancers cells To research the function of TAp73 in ovarian cancers cells in response to cisplatin, individual cisplatin-resistant ovarian cancers cell lines SKOV3 (null-p53) and OVCA433 (wild-type p53) had been stably transfected using the plasmid pEGFP-TAp73 (Body 1A). (igesip.org)

He works to identify novel drug targets and discover compounds that can weaponize the body against an enemy that uses its host's own cells, pathways and viral vectors to survive, multiply and kill. (rosalindfranklin.edu)
Two powerful tumour suppressor pathways, controlled by the p53 and retinoblastoma (pRB) proteins, are important for establishing and maintaining the senescence growth arrest. (nature.com)
Figure 4: Senescence controlled by the p53 and p16-pRB pathways. (nature.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
The cell cycle is strictly regulated and controlled by a complex network of signaling pathways [ 1 ], comprised of hundreds of proteins. (biomedcentral.com)
Moreover, a number of extracellular proteins can bind to their receptors and activate signaling pathways that promote the proliferation of cancer cells. (biomedcentral.com)
The HMGB1 signal transduction can influence the cell's fate by two important processes - apoptosis and cell proliferation - which are regulated respectively by the proteins p53 and CyclinE, acting in two different signaling pathways. (biomedcentral.com)
Many studies have found evidence of crosstalk between the two signaling pathways involving p53 and CyclinE [ 15 ]. (biomedcentral.com)
Which signaling pathways are fundamental for describing HMGB1 signal transduction, and what mechanisms are responsible to explain recent results linking overexpression of HMGB1 with decrease of apoptosis (and increased cancer cell survival)? (biomedcentral.com)
Here, we review the role of ferroptosis in p53-mediated tumor suppression, with a focus on what cellular factors are critical for p53-dependent ferroptosis during tumor suppression and how p53 modulates both the canonical (GPX4-dependent) and the non-canonical (GPX4-independent) ferroptosis pathways. (nature.com)
Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)
Among them, the Rho GTPase family plays a pivotal role in regulating the biochemical and cytoskeletal pathways relevant to cell migration. (rupress.org)
In their review " Natural and Adaptive Immunity to Cancer ", Vesely and colleagues draw from recent mouse models of cancer and human clinical data to describe how cells, effector molecules, and pathways of the immune system act to suppress and control tumor cells. (massgenomics.org)
Apparently, certain immune system pathways (e.g. inflammation) instead serve to promote tumor growth. (massgenomics.org)

The pTNM stage is a system of stage classification proposed by the American Joint Committee on Cancer which determines the degree of tumor development according with the T, N and M categories. (biorxiv.org)
However, the anti-cancer activities and potential anti-cancer mechanisms of the nutraceutical in solid tumors have not yet been elucidated. (bioinf.org)
SP141, as reported in the journal Gastroenterology in 2014, reduced levels of MDM2 in pancreatic cancer cell lines and inhibited the growth of pancreatic tumors in mice. (rosalindfranklin.edu)
Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing. (nature.com)
E6 human papillomavirus lymphadenopathy E7 cu grad ridicat de cervical cancer without high risk hpv se leagă la p53 și PRB și inactivează funcțiile lor cu dereglarea ciclului celular. (asspub.ro)
Schematic representation of the HPV double-stranded circular DNA genome Journal of Virology Nov HPV integration into the host genome and Papillomavirus life cycle To establish infection, the virus must infect cervical cancer without high risk hpv epithelial cells of stratified squamous epithelium, that are long lived or have stem cell-like properties. (asspub.ro)
UBE2D3 Protein is ideal for investigators involved in Signaling Proteins, Ubiquitin Proteins, Cancer, Cell Cycle, and Neurobiology research. (rockland.com)
For years I worked with the cells of a woman who died of cervical cancer, named Henrietta Lacks. (zppp.ro)
Without one of these tumor suppressors, cells can grow and divide unchecked, leading to the development of cancer. (medlineplus.gov)
Squamous cell cancer of the head and neck (SCCHN) is the sixth leading cause for cancer deaths worldwide. (oncotarget.com)
Microtrauma of the suprabasal epidermal cells enables the virus to infect the cell within the low risk hpv cause cancer layer. (ghise-ioan.ro)
Based on the heterogeneity within a specific tumor type, a combination of genomic alterations defines the cancer subtype, biologic behavior, and in some cases, response to therapeutics. (hindawi.com)
The significance of specific targeting towards cancer cells is debated as well. (oaepublish.com)
Even though there has been a progress achieved in the development of more effective therapies against cancer, over the past years, recurrence of tumour growth and metastatic spread in the long-term is a common event. (oaepublish.com)
In addition, many classical chemotherapeutic anti-cancer agents kill cancer cells by directly damaging their DNA, which produces high toxicity due to its non-specificity [ 3 ] . (oaepublish.com)
Cancer cells are masters in finding a way to resist the treatment designed to kill them. (oaepublish.com)
At a time when the idea that cancer had a genetic basis was widely disbelieved, Nowell's results provided the first clear evidence that a particular genetic defect in a single chromosome can lead to a population or clone of identical cells that accumulate in numbers to form a deadly malignancy. (laskerfoundation.org)
The tiny Philadelphia chromosome became a clear and consistent marker of CML, a cancer of the myeloid or bone marrow cells, with broad implications for diagnosis and prognosis of disease. (laskerfoundation.org)
Recent studies have found that overexpression of the High-mobility group box-1 (HMGB1) protein, in conjunction with its receptors for advanced glycation end products (RAGEs) and toll-like receptors (TLRs), is associated with proliferation of various cancer types, including that of the breast and pancreatic. (biomedcentral.com)
If some important proteins are mutated or there are defects in the signaling mechanisms, normal cell growth regulation will break down, possibly leading to the occurrence of cancer in the future. (biomedcentral.com)
Considering this genetic defect and the frequent genomic alterations of the NBPF1 locus in several cancer types, we hypothesized that NBPF1 is a tumor suppressor. (biomedcentral.com)
LC-MS/MS analysis was used to investigate the proteome of DLD1 colon cancer cells with induced NBPF1 expression. (biomedcentral.com)
NB tumors are derived from the sympathetic nervous system and account for approximately 15% of cancer deaths in children [ 8 ]. (biomedcentral.com)
Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, which is a form of cancer that affects the lymphatic system. (rarediseases.org)
The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)
Following that, patients may be eligible for a stem cell transplant, and/or an extended course of immunotherapy that is meant to prolong cancer remission. (rarediseases.org)
p53 represses the promoter of Polo-like kinase 1, whereas Polo-like kinase 1 inhibits p53 and its family members p63 and p73 in cancer cells lacking functional p53. (oncotarget.com)
In addition, compared to the mono-treatment, combination of Polo-like kinase 1 inhibition with anti-mitotic or DNA damaging agents boosts more severe mitotic defects, effectually triggers apoptosis and strongly inhibits proliferation of cancer cells with functional p53. (oncotarget.com)
In this regard, restoration of p53 in tumor cells with loss or mutation of p53 will reinforce the cytotoxicity of combined Polo-like kinase 1 therapy and provide a proficient strategy for combating relapse and metastasis of cancer. (oncotarget.com)
In this review, we summarize some recent findings on HPV-associated carcinogenesis, such as miRNAs in HPV-associated cancers, implication of stem cells in the biology and therapy of HPV-positive cancers, HPV vaccines, targeted therapy of cervical cancer, and drug treatment for HPV-induced intraepithelial neoplasias. (virosin.org)
2011. Human papillomavirus type 16 E6 induces cervical cancer cell migration through the p53/microRNA-23b/urokinase-type plasminogen activator pathway. (virosin.org)
Furthermore, the JNK signaling pathway plays a part in cisplatin-dependent apoptosis in cancer cells [12]C[15] critically. (igesip.org)
A similar p53-mediated transition is observed in melanoma A375P cancer cells. (rupress.org)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
Many factors are involved in causing and permitting the unregulated proliferation of cells that occurs in cancer. (msdmanuals.com)
Загальні відомості про злоякісні новоутворення Cancer is an unregulated proliferation of cells. (msdmanuals.com)
Cancer cells, particularly those arising from the bone marrow or lymphatic system, may have a short generation time, and there usually are a smaller percentage of cells in G0 (resting phase). (msdmanuals.com)
A subpopulation of cells within a cancer has the properties of stem cells. (msdmanuals.com)
As the cancer volume increases, the cancer may release angiogenesis factors, such as vascular endothelial growth factor (VEGF), which promote formation of new blood vessels that are required for further growth. (msdmanuals.com)
A cancer may release cells into the circulation at a very early stage of development. (msdmanuals.com)
Circulating cancer cells are present in many patients with advanced cancer and even in some with localized disease. (msdmanuals.com)
Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)

The p53 protein regulates Brca1 transcription both in vitro and in vivo, and Brca1 participates in p53 accumulation after gamma-irradiation through regulation of its phosphorylation and Mdm2 expression. (nih.gov)
LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. (lsbio.com)
CF treatment on leukemia cell lines induces cell death due to apoptotic mechanisms and altering 123653-11-2 manufacture cell metabolism through HIF-1 and GLUT-1 regulation [3]. (bioinf.org)
Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. (asspub.ro)
In addition, p73-mediated up-regulation of the death receptor CD95, a mediator of the extrinsic apoptotic pathway, also contributes to p73-mediated apoptosis in malignancy cells under stress stimuli [8]. (igesip.org)
Another protein, calgranulin A (Cal A), is involved in the regulation of several cell processes, including the cell cycle and cell differentiation. (bvsalud.org)

p53, guardian of the genome. (lsbio.com)
As such, p53 has 123653-11-2 manufacture been described as the guardian of the genome. (bioinf.org)
Given their essential role in protein synthesis, they occur regularly and are unlikely to disappear from a viable genome. (fascea.pics)
The initiation and development of tumor cell is accompanied by elevated stresses, such as oncogene activation, DNA damage, genome instability, and reprogrammed tumor metabolism. (nature.com)

The overexpression of profibrotic cytokine, namely transforming growth factor β (TGF-β) due to excessive inflammation and tissue damage, induces kidney fibrosis. (researchgate.net)
induces growth arrest or apoptosis depending on the physiological circumstances and cell type. (lsbio.com)
Upon treatment with Plk1 inhibitors, p53 in tumor cells is activated and induces strong apoptosis, whereas tumor cells with inactive p53 arrest in mitosis with DNA damage. (oncotarget.com)
The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
In this study, we show that p53 deficiency in mouse embryonic fibroblasts cultured in three-dimensional matrices induces a switch from an elongated spindle morphology to a markedly spherical and flexible one associated with highly dynamic membrane blebs. (rupress.org)

Intro P73, a novel member of the tumor suppressor p53 family, is similar to p53 both structurally and functionally [1], [2]. (igesip.org)

This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. (wikipedia.org)
However, the debate regarding which single function of p53 is absolutely critical for its tumor suppressor role is ongoing [ 7 ]. (nature.com)

Previous MDM2 inhibitors targeted the interaction between MDM2 and p53 and were found ineffective against cancers with mutated or deficient p53. (rosalindfranklin.edu)
Increasing evidence indicates that senescent cells could be a promising new target for therapeutic intervention known as senotherapy, which includes depleting senescent cells, modulating SASP and restoration of senescence inhibitors. (frontiersin.org)
Dr A Ranganathan, ICGEB, demonstrated generation of a novel functional protein by combining a set of DNA hexamer duplexes with a view to identify newer functional proteins and generating inhibitors for protein targets in pathogenic organisms. (ifcbiol.com)
instead, through its metabolic targets, p53 is able to modulate the ferroptosis response in the presence of ferroptosis inducers such as GPX4 inhibitors or high levels of ROS. (nature.com)
Plk1 inhibitors target all rapidly dividing cells irrespective of tumor cells or non-transformed normal but proliferating cells. (oncotarget.com)

In accordance with its tumor suppressor role, the Retinoblastoma protein pRb can ensure pro-apoptotic functions. (sdbonline.org)
Other markers, such as retinoblastoma and p53, may be related with early steps of carcinogenesis in oral cavity squamous cell carcinoma. (bvsalud.org)

The crosstalk is regulated by tumor suppressor proteins, including ARF, P21 and FBXW7, which are also frequently mutated in many cancers. (biomedcentral.com)
Lymphomas are cancers that involve white blood cells, and can be divided depending on the type of cell involved, either B-lymphocytes or T-lymphocytes. (rarediseases.org)
Mantle cell lymphoma belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system. (rarediseases.org)
We also discuss the possibility of targeting p53-mediated ferroptotic responses for the treatment of human cancers and potentially, other diseases. (nature.com)
In this scholarly study, we directed to study the result of TAp73 (TAp73) on mobile response to cisplatin in ovarian cancers cells as well as the root molecular systems. (igesip.org)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

Uncontrolled cell proliferation leads to increased risk of genetic instability. (asspub.ro)
Our data suggest that genetic alterations of p53 in tumors are sufficient to promote motility and invasion, thereby contributing to metastasis. (rupress.org)

Discrete, stochastic simulations show that p53 and MDM2 oscillations continue even after 10 hours, as observed by experiments. (biomedcentral.com)

This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (cancerindex.org)

Cystatin A (Cys A), a cysteine protease inhibitor, is a precursor of proteins involves in keratinocyte keratinization, and is expressed during the late phase of differentiation of these cells. (bvsalud.org)
Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)

The T category informs about tumor growth, depth and stage of adjacent tissues invasion. (biorxiv.org)
The amino acid sequence for this part of the protein resembled that of a human cytokine, EMAP II, which recruits circulating immune cells in tissues to promote inflammation. (fascea.pics)
CircPAPD4 expression was low in BC tissues and cells. (biomedcentral.com)
Compared with the normal tissues, the expression of MicroRNA-16-5precursor was low in glioma tissues, which was consistent with that in the Uppsala87 and Uppsala251 cell lines. (ijpsonline.com)
Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
Can ferroptosis be specifically induced in tumors but not in normal tissues? (nature.com)
Local growth is facilitated by enzymes (eg, proteases) that destroy adjacent tissues. (msdmanuals.com)

Using the PubMed database, Cochrane Library and Web of Science, studies published in English evaluating miRs differentially expressed in tumor tissue and significantly associated with the prognostic aspects of CRC were selected. (biorxiv.org)
In addition, proteome analysis of NBPF1-overexpressing DLD1 cells identified 32 differentially expressed proteins, of which several are implicated in carcinogenesis. (biomedcentral.com)

Rapid blood and lymphatic spread and breast tumor emboli are the main features ofIBC 4 . (bvsalud.org)

Conclusions These findings ascertained an conversation between p53, c-myc, p21, p27, Bcl-2, PI3K/Akt pathway, and CF-induced apoptosis in MSTO-211H and HCT-116 cells, suggesting that CF acts as an important regulator of cell growth in human malignancy cell lines. (bioinf.org)
This malignancy most commonly arises at the squamocolumnar junction, where cells are most actively undergoing metaplastic change from columnar epithelium to squamous epithelium. (medscape.com)
Our study offers shown that TAp73 triggered the JNK apoptotic signaling pathway in response to cisplatin in ovarian malignancy cells. (igesip.org)
Immunosurveillance , in which transformed cells are identified and destroyed before they can establish malignancy. (massgenomics.org)
That is, as the size of the gland decreases, the incidence of malignancy of a tumor in the gland increases in approximately these proportions. (medscape.com)

Campisi, J. Cellular senescence as a tumor-suppressor mechanism. (nature.com)
UBE2D3 also known as UBCH5C or ubiquitin-conjugating enzyme E2D 3 is a member of the E2 ubiquitin-conjugating enzyme family which is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. (rockland.com)
In this paper, the mechanism of MicroRNA-16-5p in the occurrence and development of glioma was studied by the cell experiment in vitro. (ijpsonline.com)
We demonstrated that NBPF1 exerts different tumor suppressive effects, depending on the cell line analyzed, and provide new clues into the molecular mechanism of the enigmatic NBPF proteins. (biomedcentral.com)
These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)

This mutation is often accompanied by alterations in transformation-related protein 53 (Trp53, encoding p53), which substantially accelerates mammary tumor formation. (nih.gov)
However, most female Brca1Delta11/Delta11 Trp53+/- mice develop mammary tumors with loss of the remaining Trp53 allele within 6-12 months. (nih.gov)
Heterozygous mutation of Trp53 decreases p53 and results in attenuated apoptosis and G1-S checkpoint control, allowing Brca1Delta11/Delta11 cells to proliferate. (nih.gov)

Lymphoma and ovarian tumors also occur at lower frequencies. (nih.gov)
It is this vulnerable area of the cervix, where columnar cells are actively undergoing metaplastic change to squamous epithelium, in which the majority of cervical malignancies occur. (medscape.com)
In the differentiated keratinocytes of the suprabasal layers of the epithelium, the virus switches to a rolling-circle mode of DNA replication, amplifies its DNA to high copy number, synthesizes capsid proteins, and causes viral assembly to occur 3. (ghise-ioan.ro)
An estimated 700 deaths (0.4 per 100,000 for males and 0.2 per 100,000 for females) related to salivary gland tumors occur annually. (medscape.com)

This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. (wikipedia.org)
Polo-like kinase 1, a pivotal regulator of mitosis and cytokinesis, is highly expressed in a broad spectrum of tumors and its expression correlates often with poor prognosis, suggesting its potential as a therapeutic target. (oncotarget.com)

Consistent with M1 polarization, the MWCNTs induced the production and secretion of proinflammatory cytokines tumor necrosis factor- and interleukin-1, and proinflammatory LMs leukotriene B4 (LTB4) and prostaglandin E2 (PGE2). (cdc.gov)

Inactivation of p53 Is Sufficient to Induce Development of Pulmonary Hypertension in Rats. (lsbio.com)
The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. (virosin.org)

These two therapeutic compounds both indirectly activate p53, thereby presenting a combinational non-genotoxic p53 activation strategy, in contrast to conventional chemotherapy and bone marrow transplantation. (uib.no)
Our results demonstrate that combined targeting of EGFR and Aurora kinases represents a therapeutic means to activate cell cycle checkpoints and apoptosis in SCCHN. (oncotarget.com)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)

Cellular senescence is a multifaceted process that arrests the proliferation of cells that are at risk of neoplastic transformation. (nature.com)
In mammalian organisms, cells that express markers of senescence have been shown to accumulate with age and at sites of certain age-related pathologies. (nature.com)
Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. (nature.com)
Sager, R. Senescence as a mode of tumor suppression. (nature.com)
Braig, M. & Schmitt, C. A. Oncogene-induced senescence: putting the brakes on tumor development. (nature.com)
Aging kidney and CKD share many common characteristic features with increased cellular senescence, a conserved program characterized by an irreversible cell cycle arrest with altered transcriptome and secretome. (frontiersin.org)
Senescent cells elicit their fibrogenic actions primarily by secreting an assortment of inflammatory and profibrotic factors known as the senescence-associated secretory phenotype (SASP). (frontiersin.org)
Cellular senescence is characterized by an irreversible and permanent cell cycle arrest coupled with altered transcriptome and secretome. (frontiersin.org)
Unlike apoptosis, senescence is a state of which cells are still alive and metabolically active. (frontiersin.org)
Both proteins are also involved in stopping cell division in older cells (senescence). (medlineplus.gov)
Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
Is p53-dependent ferroptosis sufficient for tumor suppression in the absence of cell cycle arrest, senescence, and apoptosis? (nature.com)
To date, various mechanisms have been suggested to explain the powerful tumor-suppressive effect of p53, including the induction of cell cycle arrest, senescence, and apoptosis. (nature.com)

Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. (lsbio.com)
A failure in regulating proliferation together with suppression of apoptosis are the 123653-11-2 manufacture minimal requirements for a cell to become cancerous [4]. (bioinf.org)
p53-mediated ferroptosis is required for its tumor suppression in mouse models. (nature.com)
What is the physiological ferroptosis inducer(s) for p53 during tumor suppression? (nature.com)

These proteins help regulate the cell cycle, which is the cell's way of replicating itself in an organized, step-by-step fashion. (medlineplus.gov)

Description Informații generale și recomandări Cancerele capului și gâtului - în majoritatea cazurilor carcinoame cu celule scuamoase HNSCC - Head and Neck Squamous Cell Carcinoma, în literatura engleză includ neoplazii ale cavității orale, orofaringelui, hipofaringelui, laringelui, tractului sinonazal și nazofaringelui. (zppp.ro)
Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)

HDACs deacetylate histones and transcription factors such as p53, leading to increased chromatin compaction, representing an additional means for silencing p53 activity. (uib.no)
VPA is a well-tolerated non-genotoxic HDAC inhibitor inhibiting deacetylation of chromatin and transcription factors such as p53, and has been found to show an anti-leukemic effect in AML patients. (uib.no)
The p53 protein is a transcription factor that normally inhibits cell growth and stimulates cell death in response to myriad stressors, including DNA damage (induced by either UV or chemical agents such as hydrogen peroxide), oxidative stress, and deregulated oncogene expression [6-10]. (bioinf.org)

Trends Cell Biol. (nature.com)
Mol Cell Biol, 30: 2983-2995. (virosin.org)
J Cell Biol (2007) 178 (1): 23-30. (rupress.org)

S315-phosphorylated p53, in contrast to other p53 phosphorylation, was shown to facilitate p53 degradation. (wikipedia.org)

3) p53 null mice develop tumors with 100% penetrance. (nature.com)

We have previously reported a mouse model in which Brca1 exon 11 is eliminated in mammary epithelial cells through Cre-mediated excision. (nih.gov)
Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. (cusabio.com)

p53 has an important protective role against undesired cell proliferation. (bioinf.org)

CDC14B has been shown to interact with p53, potentially de-phosphorylate p53 at Serine 315 and thereby stabilize p53. (wikipedia.org)
The protein serine/threonine kinase Akt (also known as protein kinase B or PKB) plays an important role in averting cell death. (bioinf.org)
Five members of the Plk family have been discovered in humans and these serine/threonine kinases have emerged as key players by performing crucial functions in the cell cycle, DNA damage response and neuron biology [ 2 - 6 ]. (oncotarget.com)
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. (abcam.cn)

Successful diagnosis and treatment of patients with salivary gland tumors require a thorough understanding of tumor etiology, biologic behavior of each tumor type, and salivary gland anatomy. (medscape.com)
Recent evidence suggests that the bicellular stem cell theory is the more probable etiology of salivary gland neoplasms. (medscape.com)

Epidermodysplasia verruciformis (EV) is a rare, inherited disorder that predisposes patients to widespread human papillomavirus (HPV) infection and cutaneous squamous cell carcinomas . (medscape.com)
HPV-5 and HPV-8 have been isolated in more than 90% of epidermodysplasia verruciformis-associated squamous cell carcinomas. (medscape.com)
Squamous cell carcinomas arise from excretory duct cells, pleomorphic adenomas arise from the intercalated duct cells, oncocytomas arise from the striated duct cells, and acinic cell carcinomas arise from acinar cells. (medscape.com)

Nutlin-3 is a non-genotoxic MDM2 antagonist, which specifically disrupts the MDM2-p53 interaction by binding to the p53 specific site on MDM2. (uib.no)

Ferroptosis acts as an independent pathway for suppressing tumor growth and is tightly connected with metabolism and oxidative stress responses. (nature.com)

This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)

Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)
Functional loss of p16 may lead to uncontrolled cell proliferation 3,4 . (bvsalud.org)

This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. (cusabio.com)

confirmed an apoptotic death for both cell lines. (bioinf.org)
Apoptosis and cell proliferation are linked by cell-cycle regulators and apoptotic stimuli that affect both processes. (bioinf.org)
Among these unconventional activities, an iron-dependent form of non-apoptotic cell death, termed ferroptosis, attracts great interest. (nature.com)
rbf1 , the Drosophila homolog of Rb , also displays a pro- apoptotic activity in proliferative cells. (sdbonline.org)
It has been previously shown that rbf1 pro-apoptotic activity depends on its ability to decrease the level of anti-apoptotic proteins such as the Bcl-2 family protein Buffy. (sdbonline.org)
The JNK signaling pathway works as an integral positive modulator of cell apoptotic response to tension stimuli [9]C[11]. (igesip.org)
There are still other, non-apoptotic paths to cell death (necrosis, autophagy, mitotic catastrophe) that are gaining attention as barriers to transformation. (massgenomics.org)

p53 is a tumour suppressor protein involved in maintenance of genomic stability of the cell. (uib.no)

The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth. (virosin.org)

Hayflick, L. The limited in vitro lifetime of human diploid cell strains. (nature.com)
These in vitro, and their expression in these human tumour virus. (who.int)

2006. Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis. (virosin.org)

Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. (lsbio.com)
The virus infects basal epithelial cells of stratified squamous epithelium. (asspub.ro)
Hpv high risk common Înțelesul "HPV" în dicționarul Engleză The virus infects basal epithelial cells of stratified squamous epithelium. (festivalulaltfel.ro)

A critical event during tumorigenesis is the conversion from a static primary tumor to an invasive, disseminating metastasis. (rupress.org)

For example, if the AARS of a pathogen is different enough from that of humans, an antibiotic could be developed that disrupts protein synthesis in the infectious agent. (fascea.pics)

Anatomy16

Organisms9

Diseases38

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes70

Disciplines and Occupations1

Information Science3

Health Care1

Genes19

Mutations16

Important tumor3

Gene18

Progression13

Malignant7

Wild type p533

Pathways14

Cancer44

Regulation6

Genome4

Induces5

Structurally and functionally1

Function of p532

Inhibitors5

Retinoblastoma2

Cancers6

Genetic2

Show that p531

Modulate1

Differentiation3

Tissues7

Differentially expressed2

Breast tumor1

Malignancy5

Mechanism5

Trp533

Occur4

Mitosis2

Necrosis factor1

Induce2

Therapeutic3

Senescence13

Suppression4

Regulate the cell cycle1

Head and neck3

Transcription3

Biol3

Phosphorylation1

Mice1

BRCA12

Undesired cell proliferation1

Serine4

Etiology2

Squamous cell carcinomas3

MDM21

Oxidative stress1

Lymphoma1

Functional2

Recombinant Protein1

Apoptotic7

Genomic1

Deacetylase activity1

Vitro2

Degradation1

Epithelial cells3

Tumorigenesis1

Disrupts1