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  • MDM2
  • This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. (cancerindex.org)
  • However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. (cancerindex.org)
  • This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. (cancerindex.org)
  • So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. (cancerindex.org)
  • Its activity is subject to a tight regulation involving a multitude of post-translational modifications.The plethora of functional protein interactions of p53 at present precludes a clear understanding of regulatory principles in the p53 signaling network.These results suggest a novel role for Mdm2 as well as for p53 sumoylation in the recruitment of p53 to nuclear bodies. (nih.gov)
  • Notably, co-expressing p53-ECFP and Mdm2-EYFP revealed that the two proteins co-localized to one or more nuclear dots, to which we will refer as p53-Mdm2 bodies (Figure 3A). (nih.gov)
  • Using an antibody against the yeast nucleolar protein Nop1, we analyzed the localization of the p53-Mdm2 bodies in respect to the nucleolus. (nih.gov)
  • As a factor that induces senescence, the role of ARF as a tumor suppressor is closely linked to the p53-MDM2 axis, which is a key process that restrains tumor formation. (molcells.org)
  • The p14ARF gene product complexes with the MDM2 protein within the nucleus, thus modulating the activity of the p53 protein. (novusbio.com)
  • Kinases
  • The first category consists of small molecules targeting the most important signalling pathway in melanoma, mitogen-activated protein kinases (MAPK) pathway. (termedia.pl)
  • This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (mcw.edu)
  • pathways
  • More recently, her lab has demonstrated that the EBNA3 proteins inhibit the cellular pathways that mediate G1 arrest. (elsevier.com)
  • These data show how parallel apoptotic pathways act together to suppress MYC-induced transformation, and how mutant MYC proteins, by selectively disabling a p53-independent pathway, enable tumour cells to evade p53 action during lymphomagenesis. (diva-portal.org)
  • Cells
  • A,B) Maximum projections from fluorescence image stacks of live yeast cells expressing the indicated fusion proteins were obtained with a DeltaVision workstation. (nih.gov)
  • D ) NARF-E6 cells were treated with IPTG and the expression of p14ARF is shown. (nih.gov)
  • Chief among these hurdles is the aggressive local invasion of malignant cells from the original tumor. (biomedcentral.com)
  • The heightened commitment to migration and reduced proliferation of invasive glioma cells makes complete surgical resection impossible, increases their resistance to chemotherapeutic agents, and reduces the efficacy of radiation treatment, which virtually assures tumor recurrence. (biomedcentral.com)
  • Improved clinical treatment will therefore ultimately require a more thorough understanding of the molecular mechanisms that regulate the invasion of glioma cells from primary tumor sites as well as the identification and specific targeting of the critical drivers of glioma invasion. (biomedcentral.com)
  • Markers
  • Necrosis, micro-vascular proliferation, and increased staining for proliferation markers histopathologically characterize the highly cellular tumor core. (biomedcentral.com)
  • localization
  • This co-localization was lost when the mutant p53W23S was used in place of wild type p53 (Figure 3B), indicating that direct binding of the proteins was required for this localization. (nih.gov)
  • Although earlier investigators possess reported mPGES-1 proteins manifestation and localization in pets, little is well known about its manifestation patterns in the central anxious system, specifically in the mind. (cylch.org)
  • proliferation
  • Dr. Sample has investigated the function of the latency-associated EBNA3A and EBNA3C that are essential for EBV-driven proliferation and demonstrated that these are transcription factors that function through a cellular intermediate, the CSL protein, which is the intracellular signaling protein of the Notch pathway. (elsevier.com)
  • Mutant MYC proteins retain their ability to stimulate proliferation and activate p53, but are defective at promoting apoptosis due to a failure to induce the BH3-only protein Bim (a member of the B cell lymphoma 2 (Bcl2) family) and effectively inhibit Bcl2. (diva-portal.org)
  • The molecular mechanisms regulating the expression of pro-invasive or pro-proliferation signaling proteins are not completely understood. (biomedcentral.com)
  • ARF is a tumor suppressor protein that has a pivotal role in the prevention of cancer development through regulating cell proliferation, senescence, and apoptosis. (molcells.org)
  • prognosis
  • In this study, we evaluated a role for the HDMX-S/FL ratio as one such biomarker, based on its association with other suppressor mutations that confer worse prognosis in sarcomas, another type of cancer that is surveilled by p53. (cancerindex.org)
  • Glioblastoma is the most aggressive primary central nervous tumor and carries a very poor prognosis. (biomedcentral.com)
  • GB is a heterogeneous group of tumors associated with a very poor clinical prognosis. (biomedcentral.com)
  • exon
  • A ) Exon/intron structure of two ubiquitously expressed and one tissue-specific protein products. (nih.gov)
  • antibody
  • There are currently no images for p14ARF/CDKN2A Antibody (NB200-111R). (novusbio.com)
  • This p14ARF antibody is used for Western blotting, where a band is seen at where a band is seen at ~16 kDa, representing p14ARF (p14ARF tends to run slightly higher than the theoretical MW of 14 kDa). (novusbio.com)
  • Regions
  • There is no resemblance between the two proteins: their coding regions are assembled by alternative splicing of two mutually exclusive 5' exons into a constitutive one containing overlapping out-of-phase reading frames. (nih.gov)
  • Comparison of nonsynonymous and synonymous evolution rates of ≈8,500 pairs of human/mouse orthologous protein-coding regions (background divergence level) to the rates within INK4a/ARF exons. (nih.gov)
  • transcript
  • A ) A transcript of GNAS1 gene contains two reading frames and produces two structurally unrelated proteins XLαs and ALEX by differential utilization of translation start sites. (nih.gov)