Tumor Suppressor Protein p53Genes, Tumor SuppressorTumor Suppressor ProteinsGenes, p53Proto-Oncogene Proteins c-mdm2Cell Line, TumorTumor Suppressor Protein p14ARFCyclin-Dependent Kinase Inhibitor p16ApoptosisCyclin-Dependent Kinase Inhibitor p21MutationGene Expression Regulation, NeoplasticNuclear ProteinsDNA DamageMolecular Sequence DataPromoter Regions, GeneticDNA-Binding ProteinsCell CycleGenes, SuppressorProtein BindingCell Transformation, NeoplasticCell ProliferationTransfectionBase SequenceProto-Oncogene ProteinsSignal TransductionCell LineNeoplasmsVon Hippel-Lindau Tumor Suppressor ProteinRetinoblastoma ProteinCell Cycle ProteinsTranscription, GeneticTranscription FactorsTranscriptional ActivationTumor Cells, CulturedDNA MethylationDown-RegulationCyclinsGene SilencingRNA, MessengerGene DeletionCell DivisionGenes, p16Tumor Markers, BiologicalLoss of HeterozygosityHCT116 CellsBlotting, WesternUbiquitin-Protein LigasesSuppressor of Cytokine Signaling ProteinsGene Expression RegulationAmino Acid SequenceNeoplasm ProteinsReverse Transcriptase Polymerase Chain ReactionRepressor ProteinsPhosphorylationRNA, Small InterferingPTEN PhosphohydrolaseRNA InterferenceProtein Structure, TertiaryTumor BurdenCell AgingSuppression, GeneticCells, CulturedProtein-Serine-Threonine KinasesFibroblastsTrans-ActivatorsTumor Necrosis Factor-alphaMice, KnockoutBinding SitesImmunohistochemistryWilms TumorApoptosis Regulatory ProteinsIntracellular Signaling Peptides and ProteinsProteinsPolymerase Chain ReactionMice, NudeCell NucleusDNA, NeoplasmMice, Inbred C57BLDNA PrimersUltraviolet RaysDNAUp-RegulationAdenocarcinomabcl-2-Associated X ProteinMicroRNAsCarrier ProteinsGene ExpressionCell Cycle CheckpointsModels, BiologicalSkin NeoplasmsBreast NeoplasmsNeoplasms, ExperimentalMice, TransgenicHeLa CellsCell SurvivalUbiquitinG1 PhaseUbiquitinationImmunoprecipitation