Cell AgingImmune ToleranceT-Lymphocytes, RegulatoryGenes, Tumor SuppressorTumor Suppressor Protein p53Tumor Suppressor ProteinsCyclin-Dependent Kinase Inhibitor p16Cell Line, TumorTumor Suppressor Protein p14ARFFibroblastsTelomereCyclin-Dependent Kinase Inhibitor p21Cell ProliferationCell Transformation, NeoplasticRetinoblastoma ProteinDNA DamageSignal TransductionGene Expression Regulation, NeoplasticMutationGenes, SuppressorAging, PrematureCell CycleNeoplasmsGenes, p53TelomeraseCell LineCells, CulturedApoptosisNuclear ProteinsVon Hippel-Lindau Tumor Suppressor ProteinTelomere Shorteningbeta-GalactosidaseDNA-Binding ProteinsAgingGene SilencingDown-RegulationMolecular Sequence DataPTEN PhosphohydrolaseTranscription FactorsCell DivisionDNA MethylationPromoter Regions, GeneticRNA, Small InterferingBase SequencePhenotypeTumor Markers, BiologicalProto-Oncogene Proteins c-mdm2RNA InterferenceSuppressor of Cytokine Signaling ProteinsRNA, MessengerTransfectionCell Cycle CheckpointsReverse Transcriptase Polymerase Chain ReactionRepressor ProteinsGenes, p16Neoplasm ProteinsLoss of HeterozygosityBlotting, WesternGene Expression RegulationCell Cycle ProteinsSuppression, GeneticTumor BurdenOncogenesGene DeletionModels, Biological