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  • Genetic
  • Contrary to early pharmacological studies, some recent genetic studies showed that in some contexts, AMPK provides survival advantage critical for tumour growth. (genengnews.com)
  • Melanoma tumors with larger volumes of genetic alterations, called mutational load, provide more targets for the immune system to detect and are more susceptible to checkpoint blockade, although that measure is not conclusive alone. (medindia.net)
  • recurrent
  • To better understand the mechanisms at work, the team analyzed tumor genomes for recurrent copy loss among nine tumor biopsies from patients who did not respond to either drug and had high burden of copy number loss. (medindia.net)
  • Analysis of a second cohort of patients confirmed the findings, with no recurrent tumor-suppressor loss found among any of the patients who had a clinical benefit or long-term survival after treatment. (medindia.net)
  • These recurrent homozygous deletions occurred either over tumor suppressors or over regions of increased genomic instability called fragile sites. (ashg.org)
  • deletions
  • We constructed a statistical model that separates fragile sites from regions showing signatures of positive selection for homozygous deletions that therefore are likely to contain tumor suppressors. (ashg.org)
  • Genomic
  • In collaboration with co-author Christina Curtis , PhD, assistant professor of medicine and of genetics, and postdoctoral scholar Jose Seoane, PhD, Attardi used human cancer genomic data to extend the paradigm further, showing that when p53 is mutated in human cancer, Yap activity increases, allowing tumors to develop. (stanford.edu)
  • In summary, through copy-number meta-analysis of large-genomic datasets, our study is significantly advancing the landscape of tumor suppressors. (ashg.org)
  • known
  • In addition, LRIG1 suppressed markers associated with tumor-initiating cells, also known as cancer stem cells, indicating the protein could knock down these dangerous cells. (ucdavis.edu)
  • Attardi
  • It's not to say that mice with the mutated version of p53 would never get cancer ," says Dr. Attardi, "but this experiment suggests that this particular mutant is really potent in limiting tumor development. (medicalnewstoday.com)
  • formation
  • As a consequence, knowing something about liver tumor formation or having a handle on how one could detect these tumors when they're much smaller could have a significant impact on survival," he said. (eurekalert.org)
  • Chen noted that more research is needed to determine whether WWP2 is functionally important in tumors or in tumor formation. (innovations-report.com)