Tumor stem cells to anticancer. Medical search. Frequent questions

These strategies will expand the toolkit for treating tumors, especially for solid tumors, drug-resistant tumors, and metastatic tumors. (springer.com)
Dr. Canter's research has a strong focus on multi-species models for natural killer (NK) cell immunotherapy, including adoptive therapy in dogs with spontaneous cancers and murine models of solid tumors. (ucdavis.edu)
Moreover, CD44 is reported as cell surface marker for cancer stem cells (CSCs) derived from solid tumors including breast, prostate, colon, head and neck and pancreatic cancer. (bio-connect.nl)
The tumor microenvironment plays a critical role in the survival, growth, invasion, and metastasis of solid tumors. (edu.pl)
CSCs have been described in several solid tumors, including prostate cancer, and contribute to therapeutic resistance and tumor recurrence. (weeksmd.com)
This study will test how safe and effective the experimental drug NUV-868 is by itself and in combination with a PARP inhibitor in people with advanced solid tumors. (facingourrisk.org)
This study will look at how well how well people with advanced ovarian, fallopian tube or primary peritoneal cancer or other solid tumors respond to treatment with the targeted therapy BAY1895344 in combination with the PARP inhibitor niraparib. (facingourrisk.org)

CSCs are enriched near macrophages, particularly near macrophage-containing intravasation sites called Tumor Microenvironment of Metastasis (TMEM) doorways. (nature.com)
Targeting macrophages to modulate the tumor immune microenvironment can ameliorate the tumor-associated immunosuppression and elicit an anti-tumor immune response. (springer.com)
Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)
In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
They can also alter the tumor microenvironment, making it less conducive to cancer cell survival and spread. (stemcells21.com)
It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. (scienceopen.com)

Malignant tumors contain stem cells, prompting worries among medical experts that the cells' transformative powers help cancers escape treatment. (medicalxpress.com)
These tumors are highly malignant - only 30 percent of people diagnosed from glioblastoma are expected to live beyond two years of their diagnosis. (inverse.com)
Immunohistological studyof mononuclear cell infiltrate in malignant gliomas. (edu.pl)
The Land laboratory has pioneered investigation of the nature and underlying principles of cancer gene cooperation originating with the discovery that multiple oncogenic mutations are required for malignant cell transformation. (rochester.edu)
Using a wide variety of experimental approaches, including genomics and systems biology, the laboratory has demonstrated that the cooperation of cancer-promoting genetic lesions is strongly reflected by synergistic modulation in signaling and the gene networks of malignant cells. (rochester.edu)
The frequency of the type of neoplasm was higher for lung cancer, followed by malignant colon tumor. (cdc.gov)
[ 4 , 5 ] ) Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
Hydatiform moles are benign placental tumors with malignant potential. (msdmanuals.com)
Gestational trophoblastic neoplasias are malignant placental tumors. (msdmanuals.com)

Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. (nature.com)
Macrophages, as one of the most abundant tumor-infiltrating cells, play an important role in tumor development and metastasis. (springer.com)
The frequency and polarization of tumor-associated macrophages (TAMs) correlate with disease progression, tumor metastasis, and resistance to various treatments. (springer.com)
Biology of Metastasis - Adhesion Molecules and Cell-Cell/Matrix Interactions 1 (Migration) ( MSc Oncology , A34C02/L/05 Tumour Physiology) (2015-present). (nottingham.ac.uk)
Biology of Metastasis - Adhesion Molecules and Cell-Cell/Matrix Interactions 2 (Invasion) ( MSc Oncology , A34C02/L/05 Tumour Physiology) (2015-present). (nottingham.ac.uk)
Lung tumor stem cells are a subpopulation of cells important for lung tumor development, metastasis, and medication resistance. (immune-source.com)
In addition, they are responsible for tumor development and metastasis also. (immune-source.com)
Recently however, the ability to enrich and characterize CSC from several tumor types based on the expression of cell surface marker phenotypes is leading to significant progress in defining the nature and roles of CSCs in tumor formation, tumor plasticity, tumor recurrence, and tumor metastasis. (bio-connect.nl)
Thus, enhanced resistance to ROS is thought to be an important contributing factor to CSC survival, and a driver of tumor growth, metastasis, and chemoresistance. (bio-connect.nl)
Emerging roles ofthe tumor-associated stroma in promoting tumor metastasis.Cell Adh Migr. (edu.pl)
In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. (scienceopen.com)
Thus, the mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis. (scienceopen.com)
Administration of Foxy-5 every fourth day did not lead to any difference in primary tumor growth, whereas it did radically reduce the level of metastasis to lung and liver compared to controls. (lu.se)
The mechanism behind the inhibited metastasis formation seemed to be impaired migration and invasion in the breast cancer cells. (lu.se)

In breast cancers from patients, the density of TMEM doorways correlates with the proportion of cancer cells expressing stem cell markers, indicating that in human breast cancer TMEM doorways are not only cancer cell intravasation portals but also CSC programming sites. (nature.com)
Studies of epithelial cancers have demonstrated that tumour cells secrete Shh ligand to signal adjacent growth factors production by stromal cells which leads to angiogenesis, tumour cell proliferation, and tumour cell survival. (wikipedia.org)
This may help explain why the expression of stem cell markers has been associated with resistance to chemotherapy and radiation treatments and poor outcome for patients with cancers including prostate, breast and lung cancers," Dr. Vasko said. (medindia.net)
That tells us that understanding how to target these markers and these cells could prove useful in treating these cancers. (medindia.net)
It will further undertake basic studies on the potential of the newly emerging iPS cell technology for reconstituting immune systems including NK cells in patients with hematologic cancers. (europa.eu)
A team of researchers led by the Whitehead and Broad Institutes has discovered a chemical that works in mice to kill the rare but aggressive cells within breast cancers that have the ability to seed new tumors. (mit.edu)
These cells, known as cancer stem cells, are thought to enable cancers to spread - and to re-emerge after seemingly successful treatment. (mit.edu)
An emerging idea in cancer biology is that tumors (breast, prostate, colon, lung, etc.) harbor a group of cells with the unique ability to regenerate cancers. (mit.edu)
Clinical trials have shown that patients with prostate, lung, and basal cell carcinoma have benefited from treatment with itraconazole, and there are additional reports of activity in leukaemia, ovarian, breast, and pancreatic cancers. (ecancer.org)
They are named tumor control cancers or cells initiating cells [4]. (immune-source.com)
After that, tumor control cells had been reported in different types of malignancies, including lung tumor, gastric tumor, human brain cancers, liver organ cancers, and digestive tract cancers [7C11]. (immune-source.com)
After the breakthrough discovery of tumor control cells, analysts attempted to appearance for effective techniques to focus on cancers control cells. (immune-source.com)
From observations in various cancers, this concept provides an opportunity for investigating the nature of anticancer drug resistance. (scienceopen.com)
A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
The first part of the study will include people with any solid tumor type, and the second part will include people with triple-negative breast, ovarian, pancreatic or prostate cancers only. (facingourrisk.org)
Increasingly, renal cell cancers are diagnosed at an earlier stage, and nephron-sparing surgery and thermal ablation are gaining acceptance as a treatment of choice for smaller tumors. (medscape.com)

Fisetin inhibits cellular proliferation and induces mitochondria-dependent apoptosis in human gastric cancer cells. (jnu.ac.in)
Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
This activation is necessary for both cell proliferation as well as glucose uptake and use. (hindawi.com)
Enhancement of head andneck squamous cell carcinoma proliferation, invasion, andmetastasis by tumor-associated fibroblasts in preclinicalmodels. (edu.pl)
MSC-derived EVs can promote the regeneration of damaged tissues, including bone, cartilage, and cardiac tissue, by enhancing cell proliferation and differentiation. (stemcells21.com)
The growth factors and cytokines present in MSC-EVs can accelerate the healing process by promoting angiogenesis and the proliferation of skin cells. (stemcells21.com)
Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. (thermofisher.com)

Yang QY, Guo NN, Zhou Y, Chen JJ, Wei QC, Han M. The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy. (springer.com)

Macrophages are emerging as major cellular factors in the tumor ecosystem that can influence the stem phenotype and cancer progression. (nature.com)
In contrast, anti-inflammatory M2 macrophages, which are predominantly present in tumors, potentiate tumor progression and immune escape. (springer.com)
Herein, we introduce the role of macrophages in tumor progression, summarize the recent advances in macrophage-centered anticancer therapy, and discuss their challenges as well as future applications. (springer.com)
By targeting residual tumor cells with precise gamma ray doses, the procedure slows the progression of a returning brain tumor. (tgh.org)
5. Singh RP , Deep G, Chittezhath M, Kaur M, Dwyer-Nield LD, Malkinson AM, Agarwal R. Effect of silibinin on the growth and progression of primary lung tumors in mice. (jnu.ac.in)
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)
However, the mechanisms by which it influences these aspects of tumor progression remain incompletely characterized. (edu.pl)
Our results suggest that the orchestrated response of macrophages and stromal elements to neoplastic cells enhances tumor progression through the release of soluble factors. (edu.pl)
FunctionalRelationship between Tumor-Associated Macrophages andMacrophage Colony-Stimulating Factor as Contributors toCancer Progression. (edu.pl)
Recent data have expanded the concept that inflammation is a critical component of tumour progression. (scienceopen.com)

Neurosurgeons at TGH perform laser interstitial thermal therapy (LITT) on patients with primary and metastatic brain tumors to reach otherwise inoperable lesions. (tgh.org)
TGH physicians were first in Hillsborough County to perform GammaTile procedures on patients experiencing recurring brain tumors such as glio- blastomas, gliomas and meningiomas. (tgh.org)
Whereas surgical resection, chemotherapy and radiation treatment have been the traditional approaches to combating these brain tumors, GammaTile offers a potentially life- prolonging option. (tgh.org)
By comparing healthy stem cells with stem cells from these brain tumors, the researchers discovered the reasons behind treatment resistance, pointing to new therapeutic strategies. (medicalxpress.com)
First author Yi-Hsien Chen, PhD, a senior postdoctoral research associate in Gutmann's laboratory, used a mouse model of neurofibromatosis type 1 (NF1) low-grade brain tumors to identify cancer stem cells and demonstrate that they could form tumors when transplanted into normal, cancer-free mice. (medicalxpress.com)
The condition can cause an array of problems, including brain tumors, impaired vision, learning disabilities, behavioral problems, heart defects and bone deformities. (medicalxpress.com)
Although the mice the researchers studied were bred to model NF1 optic gliomas, the researchers said the findings could be applied more broadly to other brain tumors . (medicalxpress.com)
This procedure increases the survival time from brain tumors by 160 to 220 percent. (inverse.com)

The role of BCSCs in cancer formation, growth, invasiveness, therapy resistance and tumor recurrence is becoming increasingly clear. (wjgnet.com)
Breast cancer stem cells (BCSCs) are the tumor cells most likely to survive anti-cancer therapies and cause breast cancer recurrence many years later. (bcrf.org)
increased metastases, tumor recurrence, and even acquired resistance against the anti-CSC therapies developed in experimental models. (bmbreports.org)

CSCs have an enhanced ability to self-renew, which makes them uniquely capable of initiating and sustaining primary and metastatic tumor growth 3 . (nature.com)
These treatments were not enough to completely inhibit tumor growth, and the cancer stem cell markers were still present," Dr. Vasko said. (medindia.net)
Treatment for NF1-related optic gliomas often includes drugs that inhibit a cell growth pathway originally identified by Gutmann. (medicalxpress.com)
In addition to promoting tumor growth, these so-called cancer stem cells are largely resistant to current cancer therapies. (mit.edu)
Ongoing research aims to understand how DAXX mediates the growth of breast tumors by keeping levels of stem cell genes low while increasing those genes required for response to therapy. (bcrf.org)
Dr. Osipo's research under Dr. Jordan focused on investigating the role of HER2/neu, the second member of the epidermal growth factor receptor family, in breast tumors that had acquired resistance to tamoxifen in vivo. (bcrf.org)
This is certainly the initial function on tumor control cells in solid growth [6]. (immune-source.com)
MSC-derived EVs can carry anti-proliferative substances to tumor cells, thereby inhibiting their growth. (stemcells21.com)
Research shows that the IAP-targeting drugs that promote the death of cancer cells also induce the growth and repair of muscle. (sciencedaily.com)
This pathway governs muscle growth and repair by promoting the fusion of muscle cells to create new muscle fibres or repair damaged fibres. (sciencedaily.com)
Mar. 29, 2022 Researchers discovered that two distinct classes of fibroblast cells accumulate in pancreatic tumors and play opposing roles to promote and restrain pancreatic cancer growth. (sciencedaily.com)
Feb. 10, 2021 Muscle stem cells drive the tissue's growth and repair after such injuries. (sciencedaily.com)
The ability of metformin to block tumor growth and prolong remission in xenografts in combination with doxorubicin is associated with decreased function of the inflammatory feedback loop. (weeksmd.com)
Recombinant cytokines, required for the optimal growth and expansion of T cells, have not been added to ImmunoCult™-XF T Cell Expansion Medium. (stemcell.com)
Such non-mutational processes are largely driven by tumor cell plasticity, which renders tumor cells insusceptible to the drug-targeted pathway, thereby facilitating the tumor cell survival and growth. (scienceopen.com)
Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells. (rochester.edu)
Bauer Research Foundation published on December 12, 2012 that Praziquantel , my other favorite parasite medication for liver flukes, synergistically enhances Paclitaxel (Taxol) efficacy to inhibit cancer cell growth (PloS ONE 7(12): e51721). (thehealthyplanet.com)
Peptides R, S and I were chosen for evaluation in in vivo models of lung metastases (B16-CXCR4 and KTM2 murine osteosarcoma cells) and growth of a renal cells xenograft. (cnr.it)
All three peptides significantly inhibited subcutaneous growth of SN12C-EGFP renal cancer cells. (cnr.it)
Three peptides, R, I and S inhibited lung metastases and primary tumor growth and will be evaluated as anticancer agents. (cnr.it)

These same molecules are found in embryonic stem cells. (medindia.net)
It does not use embryonic stem cells. (agelessway.org)
Yes, I worked with Gail Martin on embryonic stem cells and then returned to Harvard in 1986. (medscape.com)

Researchers have recently debated the notion that some therapies are not capable of eradicating cancer because they do not target the cancer stem cells responsible for tumor development. (medindia.net)
They then applied various therapies - from VEGF inhibitors such as Avastin to the proteasome inhibitor Velcade - in mice implanted with human MSC, and analyzed the effects on tumors. (medindia.net)
Some novel therapies are already being tested against cancer stem cells, he added. (medindia.net)
The project will support anti-tumor and anti-viral therapies by developing novel technology for NK cell generation from cord blood stem cells for NK cell infusions in patients, by genetic engineering of NK cells and by using NK receptors and their ligands to develop novel reagents for amplifying anti-tumor and -viral activities of NK/T cells. (europa.eu)
Many therapies kill the bulk of a tumor only to see it regrow," says Eric Lander, director of the Broad Institute of MIT and Harvard, and an author of the Cell paper. (mit.edu)
For other studies, they collected breast cancer biopsies before and after pre-surgical (neoadjuvant) endocrine therapy or chemotherapy to determine how the levels of DAXX and other cancer stem cell biomarkers are affected by neoadjuvant therapies. (bcrf.org)
There is potential to treat autoimmune diseases by using EVs to alter the immune system's behavior without the risks of integrating DNA into the patient's genome, which is a concern with whole-cell therapies. (stemcells21.com)
There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)
There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)

Tumor angiogenesis andprogression are enhanced by Sema4D produced by tumorassociatedmacrophages. (edu.pl)

In mammary gland development, Notch-dependent heterotypic signaling between resident tissue macrophages and mammary stem cells supports survival and function of the normal mammary stem cell 20 . (nature.com)
Developing strategies to block the survival of dormant breast cancer stem cells in order to improve patient outcomes. (bcrf.org)
In this study, which was only on mice, the procedure increased the survival time of the mice by 160 to 220 percent - depending on the size of the tumor. (inverse.com)
Key international collaborations include Johns Hopkins University, Mayo Clinic and University of Louvain, with a research highlight demonstrating a long-term survival benefit in orthotopic brain tumour models when combined chemotherapeutics are delivered at neurosurgery via a biodegradable paste ( Clinical Cancer Research 25 (16): 5094-5106, 2019). (nottingham.ac.uk)
The ability to avoid the consequences of exposure to high levels of ROS is required for cancer cell survival and propagation in vivo . (bio-connect.nl)
These anti-cancer drugs target the IAP genes, an important family of proteins related to tumour survival that were discovered by the Children's Hospital of Eastern Ontario (CHEO) group over 15 years ago. (sciencedaily.com)
ANCILLARY STUDIES ARE PLANNED: PD-L1 Combined Positivity Score on carcinoma cells and stromal immune cells of diagnostic biopsy specimen will be correlated to disease free survival. (bvsalud.org)

The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
We hypothesize that the tumor escapes from chemotherapy by induction of stem cell marker expression," he said. (medindia.net)
They have shown that high amounts of the DAXX gene correlate with a reduction in the number of BCSCs and a better response to endocrine therapy, standard chemotherapy, and PARP inhibitor treatment in ER-positive and TNBC cells. (bcrf.org)
In addition, they found high levels of the DAXX gene in ER-positive breast cancer cells inhibited endocrine therapy resistance and DAXX status also predicted sensitivity to chemotherapy, DNA damage response, and PARP inhibition in TNBC cells. (bcrf.org)
In the latest years, people discovered that there is certainly a little subpopulation of cells in tumors, which play a essential function in the resistance of cancer to radiotherapy and chemotherapy. (immune-source.com)
Anticancer medicines ( chemotherapy ) may be recommended if the tumor has spread. (medlineplus.gov)
High-dose chemotherapy, autologous stem cell transplantation , and immunotherapy are also being used. (medlineplus.gov)
Chemotherapy is used only occasionally, in certain tumor types. (medscape.com)
Chemotherapy-induced mucositis is one of the most important undesirable side effects of cancer treatment, promoting the worst cases of morbidity, increasing length of hospital stay, and frequently reducing the odds of controlling the tumor and the patient's life expectancy 1 . (bvsalud.org)

2. Received any of the anti-tumor treatments(note in the protocol) before the first study drug. (mycancergenome.org)

Besides, biomimetic carriers based on macrophages have been extensively explored to prolong circulation, enhance tumor-targeted delivery, and reduce the immunogenicity of therapeutics to augment therapeutic efficacy. (springer.com)
Komohara Y, Fujiwara Y, Ohnishi K, Takeya M. Tumor-associated macrophages: potential therapeutic targets for anti-cancer therapy. (springer.com)
Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer. (springer.com)
The research paper presented by the American Association for Cancer Research's second International Conference on Molecular Diagnostics in Cancer Therapeutic Development say that anti-cancer treatments might have an opposite effect, actually expanding the small population of cancer stem cells believed to drive the disease though quite often they effectively shrink the size of tumors. (medindia.net)
If scientists understood the pathways cancer stem cells use to survive treatment or increase their ranks, then therapeutic targets could be developed, Dr. Vasko said. (medindia.net)
Although further work is needed to determine whether this specific chemical holds therapeutic promise for humans, the study shows that it is possible to find chemicals that selectively kill cancer stem cells. (mit.edu)
According to recent findings, especially targeting cancer stem cells (CSCs) is the most promising therapeutic strategy. (bmbreports.org)
EVs can be engineered to deliver specific therapeutic agents directly to targeted cells, reducing the systemic side effects of drugs. (stemcells21.com)
These cells have shown therapeutic potential in treating a variety of conditions, from degenerative diseases to anti-aging applications. (stemcells21.com)
These exosomes are rapidly taken up by various cell types in the body, offering initial therapeutic benefits that complement the sustained regenerative effects of the MSCs. (stemcells21.com)
This expanded knowledge of tumor cell plasticity contributes to developing novel therapeutic strategies or combination therapy regimens using available anticancer drugs, which are likely to improve patient outcomes in clinical practice. (scienceopen.com)
In this study, we examined the therapeutic potential of a cold plasma jet in cancer cell lines and tumours, focusing on selective tumour cell eradication capabilities and signalling pathway deregulation. (nature.com)

With an ample number of stem cells in hand, the Broad-Whitehead team undertook a large-scale analysis of thousands of chemical compounds, applying automated methods to search for ones with activity against breast cancer stem cells. (mit.edu)
Drs. Osipo and Albain have shown that increasing DAXX levels in breast cancer cells effectively kills all breast cancer cells including BCSCs. (bcrf.org)
I am a clinician-scientist and Joint Head of the ACRF Cancer Biology and Stem Cells Division and Breast Cancer Laboratory. (edu.au)
Our group is studying molecular regulators of normal mammary gland development and cancer, with a particular interest in understanding how mammary stem cells and their progeny contribute to the mammary epithelial cell hierarchy and breast cancer. (edu.au)
Scientific Advisory Boards: National Breast Cancer Foundation, National Stem Cell Foundation of Australia and Cancer Science Institute (Singapore), Victorian Cancer Biobank, Pfizer, AbbVie. (edu.au)
Board Member: National Stem Cell Foundation of Australia, Executive member kConFab (Kathleen Cuningham Foundation Consortium for research into Familial Breast cancer). (edu.au)
Notch signaling is aberrantly activated in breast cancer, non‑small‑cell lung cancer and hematological malignancies, such as T‑cell acute lymphoblastic leukemia and diffuse large B‑cell lymphoma. (spandidos-publications.com)
By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)
Targeting tumor-associatedmacrophages as a novel strategy against breast cancer. (edu.pl)
A reality TV show provided the inspiration for a company that is developing stem cell-derived nipple and areola tissue for reconstructive procedures for breast cancer survivors. (medpagetoday.com)
Metformin, the first-line drug for treating diabetes, inhibits cellular transformation and selectively kills cancer stem cells in breast cancer cell lines. (weeksmd.com)
Taxol is a common chemo agent for ovarian cancer, breast cancer, small cell lung cancer, head and neck cancer, esophageal cancer, prostate and bladder cancer. (thehealthyplanet.com)
The purpose of this study is to see whether the combination of melphalan, BCNU, hydroxocobalamin, ascorbic acid, and autologous (self) bone marrow stem cell infusion, is safe and effective for treating patients with advanced pancreatic cancer or Stage IV, HER2-negative breast cancer who have a BRCA1, BRCA2 or PALB2 inherited mutation. (facingourrisk.org)
Today, anticancer treatment can control primary breast tumors, but treatment and prevention of metastatic disease still represents a major challenge in the management of breast cancer patients. (lu.se)
The findings presented in this thesis show that Wnt-5a inhibits the metastatic behaviour of breast cancer cells by blocking Ca2+-induced NFAT activation. (lu.se)
Experiments were performed in which the mammary fat pads of athymic (immunodeficient) BALB/c mice and normal BALB/c mice were inoculated with 4T1 breast cancer cells. (lu.se)
In addition, the Wnt-5a coreceptor Ror2 was found to be involved in regulation of breast cancer cell migration and to associate with DDR1, a tyrosine kinase receptor that participates in Wnt-5a signaling. (lu.se)
The environment in which breast cancer arises -the interplay between the patient's BMI, tumour size and cancer-specific proteins -is of importance for the prognosis. (lu.se)

Blood and tissue biomarker analysis in dogs with osteosarcoma treated with palliative radiation and intra-tumoral autologous natural killer cell transfer. (ucdavis.edu)
Cell and Tissue Engineering ' (2007-present). (nottingham.ac.uk)
Typically, rapidly proliferating tumor cells have glycolytic rates up to 200 times higher than those of their normal tissue of origin, even in the presence of oxygen [ 3 ]. (hindawi.com)
These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
Neuroblastoma is a very rare type of cancerous tumor that develops from nerve tissue. (medlineplus.gov)
In one aspect, for example, an isolated cell that is capable of self-renewal and culture expansion and is obtained from a subepithelial layer of a mammalian umbili-cal cord tissue. (therapeuticsolutionsint.com)
It is being developed to attack the targeted tumor tissue locally with little damage to the surrounding normal tissues, but it is extremely challenging to allow the nanoparticles to be specifically transported throughout the tumor. (vinastemcelllab.com)
The tissue of origin for renal cell carcinoma (RCC) is the proximal renal tubular epithelium. (medscape.com)

Here, we employ high-resolution intravital microscopy using a CSC biosensor to directly observe CSCs in live mice with mammary tumors. (nature.com)
CSCs display the slow-migratory, invadopod-rich phenotype that is the hallmark of disseminating tumor cells. (nature.com)
At the apex of the hierarchy are the cancer stem cells (CSCs). (nature.com)
miRNAs are the key regulators of cancer stem cells (CSCs) which play a central role in inducing chemoresistance and implying metastatic potential to the pancreatic tumor cells (Singh S., et al. (unmc.edu)
CSCs take charge of a cancer hierarchy, harboring stem cell-like properties involving self-renewal and aberrant differentiation potential. (bmbreports.org)
For the past 20 years, plenty of studies have suggested that only a small subpopulation of the cancer cells with tumor-initiating capability is the core origin of the tumorigenesis and the subset of cancer cells was named cancer stem cells (CSCs). (bmbreports.org)
As it can be inferred from its nomenclature, CSCs share several features of normal stem cells. (bmbreports.org)
Cancer stem cells (CSCs) are defined as a small, self-renewing cell population within a tumor that can give rise to all other tumor cell types found within that tumor. (bio-connect.nl)
However, as CSCs make up only a very small, and diffuse, population of total tumor mass, detailed functional analyses critical to the development of such strategies has been difficult. (bio-connect.nl)
In vitro sphere formation assays are a type of colony formation assay used to evaluate the clonogenic potential of CSCs and other stem cells. (bio-connect.nl)

Mechanistically, stemness is induced in non-stem cancer cells upon their direct contact with macrophages via Notch-Jagged signaling. (nature.com)
90% of cancer-related deaths, is a multi-step process involving cancer cell intravasation into the bloodstream, dissemination to distant sites, and seeding in new organs 1 . (nature.com)
Solinas G, Germano G, Mantovani A, Allavena P. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. (springer.com)
Our experiments suggest that some treatments could be producing more cancer stem cells that then are capable of metastasizing, because these cells are trying to find a way to survive the therapy," said one of the study's investigators, Vasyl Vasko, M.D. Ph.D., a pathologist at the Uniformed Services University of the Health Sciences in Bethesda, Md. (medindia.net)
The cancer stem cell markers include Nanog and BMI1, both of which contribute to stem cells' defining ability to renew themselves and differentiate into different cell types, Dr. Vasko said. (medindia.net)
But analysis of stem cell expression before and after treatment revealed that even as some anti-cancer treatments shrank tumors, they increased expression of Nanog and BMI1. (medindia.net)
Use of the agents Velcade and Docetaxel led to the most significant increase in stem cell markers within the treated tumor, while ifosfamide and Avastin inhibited expression of the markers in this cancer subtype. (medindia.net)
Dr. Vasko doesn't know how this happens, but theorizes that "dying cells could secrete a lot of factors that induce expression of stem cell markers in other cancer cells. (medindia.net)
The ChemoID functional anti-cancer assay targets live cancer stem cells along with the bulk of the tumor cells. (tgh.org)
Researchers at Washington University School of Medicine in St. Louis are studying how cancer stem cells make tumors harder to kill and are looking for ways to eradicate these treatment-resistant cells. (medicalxpress.com)
Scientists are eager to make use of stem cells' extraordinary power to transform into nearly any kind of cell, but that ability also is cause for concern in cancer treatment. (medicalxpress.com)
New research proves that the threat posed by cancer stem cells is more prevalent than previously thought. (medicalxpress.com)
The low-grade brain cancer stem cells identified by the scientists also were less sensitive to anticancer drugs. (medicalxpress.com)
In laboratory tests conducted as part of the new research, it took 10 times the dosage of these drugs to kill the low-grade cancer stem cells. (medicalxpress.com)
Compared with healthy stem cells from the brain, the cancer stem cells made more copies of a protein called Abcg1 that helps those cells survive stress. (medicalxpress.com)
If we can identify a drug that disables this protein, it would make some cancer stem cells easier to kill. (medicalxpress.com)
Because stem cells haven't differentiated into specialized cells, they can easily activate genes to turn on new developmental programs that allow the cells to survive cancer treatments," said Gutmann, who directs the Washington University Neurofibromatosis Center. (medicalxpress.com)
Mouse low-grade gliomas contain cancer stem cells with unique molecular and functional properties. (medicalxpress.com)
Sodium butyrate induces DRP1-mediated mitochondrial fusion and apoptosis in human colorectal cancer cells. (jnu.ac.in)
Evidence is accumulating rapidly that cancer stem cells are responsible for the aggressive powers of many tumors," says Robert Weinberg, a member of Whitehead Institute for Biomedical Research and one of the authors of the study. (mit.edu)
If it were possible to identify chemicals that selectively kill cancer stem cells, such chemicals might become critical candidates for future drug development. (mit.edu)
However, researchers have struggled to study cancer stem cells directly in the laboratory. (mit.edu)
To overcome these hurdles, Broad and Whitehead Institute researchers drew upon recent findings from Weinberg and his colleagues that suggested a way to generate in the laboratory large numbers of cancer cells with stem cell-like qualities. (mit.edu)
A critical aspect of our work was to generate relatively homogenous and stable populations of cancer stem-like cells that could then be used for screening," says Tamer Onder, a former graduate student in Weinberg's lab and co-first author of the study. (mit.edu)
We were able to achieve this by inducing the cancer cells into an epithelial-to-mesenchymal transition using novel reagents that we had developed in the lab. (mit.edu)
Our laboratory is also using patient derived xenograft (PDX) and tumor organoid models to test promising anti-cancer agents. (edu.au)
In a groundbreaking discovery, scientists have figured out how to turn skin cells into cancer-fighting stem cells. (inverse.com)
These had the ability to move about the brain, killing cancer cells. (inverse.com)
They were also engineered with a tumor-killing protein, making them highly effective at their cancer-killing job. (inverse.com)
In their next study, the researchers hope to focus on human stem cells and test effective anti-cancer drugs that can be loaded onto the neural stem cells. (inverse.com)
However, Notch signaling is inactivated in small‑cell lung cancer and squamous cell carcinomas. (spandidos-publications.com)
The Notch signaling network exerts oncogenic and tumor‑suppressive effects in a cancer stage‑ or (sub)type‑dependent manner. (spandidos-publications.com)
Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)
Small-molecule inhibitors, antagonistic monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), bispecific antibodies or biologics (bsAbs) and chimeric antigen receptor-modified T cells (CAR-Ts) targeting Notch signaling components have been developed as investigational anti-cancer drugs ( 10 - 12 ). (spandidos-publications.com)
His research is now focused on further characterization of the activating and inhibitory receptors of NK cells as part of a multi-species evaluation of optimizing NK cancer immunotherapy, and they are broadening their dog canine immunotherapy comparative oncology clinical trials with other novel immune agents. (ucdavis.edu)
Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy. (ucdavis.edu)
through targeting lung cancer stem cells. (immune-source.com)
Lung cancer majorly consists of small-cell lung carcinoma and non-small-cell lung carcinoma (NSCLC). (immune-source.com)
Sphere Formation The lung cancer stem cells were accumulated by sphere formation. (immune-source.com)
Examples of preparative CSC enrichment from human cancer cell lines using anti-CD44 v9 antibody RV3 (Cat. (bio-connect.nl)
The figure below compares the sphere formation ability of CD44 v9-High and CD44 v9-Low cell populations sorted from a human prostate cancer cell line (PC-3) using anti-human CD44 v9 antibody RV3 (Cat. (bio-connect.nl)
In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
In contrast to normal cells, most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactate fermentation, even in the presence of oxygen, a less efficient metabolism compared to a low rate of glycolysis followed by mitochondrial oxidation of pyruvate [ 2 ]. (hindawi.com)
Metabolic adaptations of cancer cells. (hindawi.com)
Glucose and glutamine are the 2 major substrates used by cancer cells. (hindawi.com)
2] Anton K, Glod J. Targeting the tumor stroma in cancer therapy.Curr Pharm Biotechnol. (edu.pl)
Laboratory studies have provided clues to how cancer stem cells thrive in a low-oxygen environment (hypoxia), allowing them to proliferate and spread to distant sites in the body. (medpagetoday.com)
Almost as soon as new cancer drugs become available, tumors develop new ways to evade the drugs' anticancer activity, in this case, drugs targeting the CDK4/6 pathway . (medpagetoday.com)
Metformin and Cancer STEM cells. (weeksmd.com)
So this is a cheap and relatively safe remedy for cancer STEM cells. (weeksmd.com)
One potential target is the cancer stem cell (CSC). (weeksmd.com)
Metformin preferentially inhibits nuclear translocation of NF-ÎºB and phosphorylation of STAT3 in cancer stem cells compared with non-stem cancer cells in the same population. (weeksmd.com)
The concept of tumor cell plasticity highlights the significance of re-activation of developmental programs that are closely correlated with epithelial-mesenchymal transition, acquisition properties of cancer stem cells, and trans-differentiation potential during drug exposure. (scienceopen.com)
Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. (scienceopen.com)
This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention. (scienceopen.com)
blue is cell nucleus and yellow represents the garbage recycling process that occurs as cancer grows. (rochester.edu)
Carcinogenesis is a process driven by multiple co-operating oncogenic mutations in which features of the cancer cell phenotype, such as proliferative advantage, only emerge as a result of the interplay between these mutations. (rochester.edu)
Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility. (rochester.edu)
A physician who heard my lecture at one of the conferences told me that Ivermectin has anti-cancer properties and anti-cancer stem cell properties. (thehealthyplanet.com)
Cancer stem cells are the reason why cancer cells often develop resistance to chemotherapies. (thehealthyplanet.com)
These researches are telling us that a combination of chemo agents with Ivermectin is targeting cancer stem cells. (thehealthyplanet.com)
Killing cancer stem cells is the holy grail of cancer therapy. (thehealthyplanet.com)
This study is looking at the effectiveness of combining a PARP inhibitor called niraparib and an immunotherapy called dostarlimab for treating people with an inherited BRCA mutation (found with genetic testing) or a tumor mutation (found through tumor testing) who have breast, pancreatic, ovarian, fallopian tube or primary peritoneal cancer that is metastatic or advanced and cannot be removed by surgery (unresectable). (facingourrisk.org)
PETRA is studying a new PARP inhibitor AZD5305 taken either alone or combined with other treatments in people with advanced ovarian, breast, prostate or pancreatic cancer with an inherited or tumor mutation in: BRCA1/2, PALB2, RAD51C or RAD51D. (facingourrisk.org)
Gold nanoparticle-assisted photothermal therapy is a disease theranostic application by using gold nanoparticles for bioimaging and killing cancer cells through thermal emission in luminescence process. (vinastemcelllab.com)
Therefore, the combination of gold nanorods with human iPS cells as a theranostic platform paves an alternative road for cancer theranostics and holds great promise for clinical translation in the near future. (vinastemcelllab.com)
Both in-vitro and in-vivo studies revealed that cold plasmas selectively kill cancer cells. (nature.com)
The development of cold plasma tumour ablation has the potential of shifting the current paradigm of cancer treatment and enabling the transformation of cancer treatment technologies by utilisation of another state of matter. (nature.com)
The CXCR4/CXCL12 axis plays a role in cancer metastases, stem cell mobilization and chemosensitization. (cnr.it)
Renal cell carcinoma (see the image below) is the most common type of kidney cancer in adults. (medscape.com)
Genetic studies of the families at high risk for developing renal cancer led to the cloning of genes whose alteration results in tumor formation. (medscape.com)
By reprogramming tumour cells to become the body's defenders, Filipe Pereira and his colleagues hope to improve current cancer treatments. (lu.se)
By using cells isolated from cancer patients and mixing them with a new technology called "OssiGel", it is possible to engineer human mini-bones. (lu.se)

The researchers first determined that Nanog and BMI1 stem cell markers were more highly expressed in metastatic tumors compared to primary tumors. (medindia.net)

Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
Proof of concept for efficient CXCR4 inhibition has been demonstrated in stem cell mobilization prior to autologous transplantation in hematological malignancies. (cnr.it)

To do this, the team reprogrammed stem cells called fibroblasts, which are used to create collagen and connective tissues, into neural stem cells. (inverse.com)

The technique works by coaxing adult cells to undergo a critical change (known as an "epithelial-to-mesenchymal transition") that alters their shape and motility. (mit.edu)
In this study, we show that human glioblastoma cells secrete soluble factors that alter the phenotype and cytokine secretion profile of both macrophages and mesenchymal stem cells (MSCs). (edu.pl)
Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a variety of cell types and have the potential to repair body tissues. (stemcells21.com)
Mesenchymal stem cells, commonly referred to as MSCs, are multipotent cells with powerful regenerative, immunomodulation, anti-inflammatory effects. (stemcells21.com)
While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)
Abstract: Disclosed are methods of reducing lung inflammation in acute respiratory distress syndrome elicited by various factors such as COVID-19 infection by reduction of neutrophil extracellular trap formation through administration of mesenchymal stem cells and/or exosomes thereof. (therapeuticsolutionsint.com)
The invention provides means of inhibiting neutrophil release of extracellular traps by mesenchymal stem cells and/or exosomes derived from said mesenchymal stem cells. (therapeuticsolutionsint.com)
Additionally, synergies are provided between mesenchymal stem cells and/or exosomes derived from mesenchymal stem cells and agents approaches which reduce neutrophil extracellular trap formation. (therapeuticsolutionsint.com)
To determine safety and efficacy of 100 million intravenously administered CTEcells™ allogeneic umbilical cord mesenchymal stem cells. (therapeuticsolutionsint.com)
To determine safety and efficacy of intravenously administered allogeneic JadiCell umbilical cord blood mesenchymal stem cells in patients with moderate-to-severe COPD. (therapeuticsolutionsint.com)

Renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies and 90-95% of neoplasms arising from the kidney. (medscape.com)
In children and adolescents, salivary gland tumors make up 0.5% of all malignancies. (medscape.com)

The development of effective nucleic acid therapeutics demands teamwork among scientists with expertise in molecular and cell biology, biochemistry, biophysics, polymer chemistry, colloid science, pharmaceutics, and medicine. (unmc.edu)
Placenta-derived stem cells are being considered for similar uses and are in Phase III clinical trial for critical limb ischemia by Israel's Pluristem Therapeutics. (biomedcentral.com)
We have chosen to concentrate on the emerging therapeutics that broadly involves a wide range of cell types in clinical trials registered on the National Institutes of Health's clinical trials web site. (biomedcentral.com)

The molecular biology and genetics of brain tumour cells grown as 3D cultures better resembles the biology of the patients' tumour, when compared to traditional 2D cultures. (nottingham.ac.uk)
Study summary: A novel cyanobacterial ligand for human L-selectin extracted from Aphanizomenon flos aquae potential role for stem cell biology in vitro and in vivo? (agelessway.org)
Cold Spring Harbor, NY -- Cold Spring Harbor Laboratory Press (CSHLP) announced the release of The Digital Cell: Cell Biology as a Data Science, available on its website in hardcover format. (cshlpress.com)
What happens when you mix a group of tumor biology researchers with software developers and AI researchers? (lu.se)

The evidence for these anticancer effects, in vitro , in vivo , and clinical are summarised, and the putative mechanisms of their action outlined. (ecancer.org)
National Library of Medicine s PubMed database: Mobilization of human CD34+ CD133+ and CD34+ CD133(-) stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae--related to modulation of CXCR4 expression by an L-selectin ligand? (agelessway.org)
In this ongoing work, we examined the impact of thioridazine on LCSCs world development, chemoresistance, cell cycle, and in vivo prohibitory function. (immune-source.com)
and (b) significantly reduces tumour size in vivo . (nature.com)

Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
In the research part we will deal with the basic principles of the innate immune defense used to control tumors and viral infections with a focus on NK and NK/T cells, including analysis of NK receptor genomics/epigenetics, gene polymorphisms/disease linkage, differentiation of hitherto unrecognized NK cell subpopulations and novel ligands for NK receptors exposed by tumor and/or virally infected cells. (europa.eu)
We will investigate the mechanisms installed by tumors and viruses to avoid or subvert immune defenses. (europa.eu)
This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)
We're invoking antigen (Ag)-specific responses via direct injections of recombinant lentivectors (LVs) that encode sequences for tumor-associated antigens into a number of lymph nodes to optimize immune presentation/stimulation. (chxa.com)
Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade. (cdc.gov)

4. Patients who had received hematopoietic stem cell transplantation within 3 months before the first administration 5. (mycancergenome.org)

The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
Led by nationally renowned CyberKnife expert and radiation oncologist Dr. Brian Collins, the CyberKnife program at TGH offers the most advanced radiosurgery available today to patients iwht tumors of the brain, spine, and other areas of the body. (tgh.org)
Patients are randomly assigned in a 1:1 ratio in each arm with a stratification according to tumor stage, histology and centre. (bvsalud.org)
OBJECTIVE: We investigated the efficacy and safety of afatinib maintenance therapy in patients with head and neck squamous cell carcinoma (HNSCC) with macroscopically complete resection and adjuvant radiochemotherapy (RCT). (bvsalud.org)
Impaired Seroconversion After Severe Acute Respiratory Syndrome Coronavirus 2 mRNA Vaccine in Patients With Thymic Epithelial Tumors. (cdc.gov)
Successful diagnosis and treatment of patients with salivary gland tumors require a thorough understanding of tumor etiology, biologic behavior of each tumor type, and salivary gland anatomy. (medscape.com)
We describe laboratory-confirmed influenza A pandemic (H1N1) 2009 in 17 hospitalized recipients of a hematopoietic stem cell transplant (HSCT) (8 allogeneic) and in 15 patients with malignancy treated at 6 Australian tertiary centers during winter 2009. (cdc.gov)
The protective effect of seasonal influenza vaccination is reduced in patients with hematologic malignancy and recipients of an allogeneic hematopoietic stem cell transplant (HSCT) ( 5 , 6 ). (cdc.gov)

Or, the tissues of the tumor may mature and develop into a non-cancerous (benign) tumor called a ganglioneuroma , which can be surgically removed. (medlineplus.gov)
Most tumors (65%) are benign, with hemangiomas being the most common, followed by pleomorphic adenomas. (medscape.com)

A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
EMT endows cells with migratory and invasive properties, induces stem cell properties, prevents apoptosis and senescence, and contributes to immunosuppression. (scienceopen.com)
Inhibiting PAK1 signals induce tumor cell apoptosis (cell death). (thehealthyplanet.com)
In one embodiment stem cells are administered in order to protect the endothelium from apoptosis and to preserve the blood brain barrier. (therapeuticsolutionsint.com)

Genes to cells : devoted to molecular & cellular mechanisms 2023 0 0. (cdc.gov)

These genes are either tumor suppressors ( VHL , TSC ) or oncogenes ( MET ). (medscape.com)

Furthermore, macrophages were shown to contribute to a niche that can support and maintain a breast CSC (BCSC) phenotype through heterotypic CD90/EphA4 signaling between macrophage and tumor cell 14 . (nature.com)
Pro-inflammatory M1 macrophages hold the potential to engulf tumor cells. (springer.com)
Moreover, the genetic engineering of macrophages with chimeric antigen receptor (CAR) allows them to recognize tumor antigens and perform tumor cell-specific phagocytosis. (springer.com)
Macrophages and MSCs respond to tumor-secreted factors by increasing the release of interleukin-6 (IL-6) and this response is potentiated when macrophages and MSCs are combined in co-culture. (edu.pl)

StemEnhance by StemTech uses an extract from Aphanizomenon flos-aquae (fresh water botanical) to support the natural release of stem cells from our bone-marrow thus increasing the number of stem cells circulating in our bodies. (agelessway.org)
Mobilization of bone marrow stem cells with StemEnhance improves muscle regeneration in cardiotoxin-induced muscle injury. (agelessway.org)

That is, as the size of the gland decreases, the incidence of malignancy of a tumor in the gland increases in approximately these proportions. (medscape.com)

The paper states Ivermectin synergizes with chemo agents cytarabine and daunorubicin to induce cell death in leukemia cells. (thehealthyplanet.com)

Whereas the standard isoform of CD44 (CD44 s) is expressed predominantly in hematopoietic cells and normal epithelial cell subsets, CD44v (variant) isoforms contain insertions in the membrane-proximal extracellular region and are highly expressed in epithelial-type carcinomas. (bio-connect.nl)
One of the peptides was shortened and modified to yield the formylated hexapeptide, Foxy-5, which was able to copy the effects of Wnt-5a on the intracellular signaling, adhesion and migration of breast epithelial cells. (lu.se)

Nevertheless, till today, no one provides reported whether thioridazine could focus on lung tumor control cells. (immune-source.com)
Tumor-associated macrophagesinfiltration is associated with peritumoral lymphangiogenesisand poor prognosis in lung adenocarcinoma. (edu.pl)

Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)

Steroid hormone receptor status of mouse mammary stem cells. (edu.au)

Outcomes and Management of SARS-CoV2 Omicron Variant in Recipients of Hematopoietic Cell Transplantation (HCT) and Chimeric Antigen Receptor T cell (CART) therapy. (cdc.gov)
Experimental treatment approaches include vaccines and nonmyeloablative allogeneic peripheral blood stem cell transplantation. (medscape.com)

Lastly, metformin-based combinatorial therapy is effective in xenografts involving inflammatory prostate and melanoma cell lines, whereas it is ineffective in noninflammatory cell lines from these lineages. (weeksmd.com)

Yanlie Liu and colleagues from School of Electronic Information and Electrical Engineering and Shanghai Jiao Tong University in China used pluripotent stem cells (iPS) as transporters with remarkable tumor target migration ability to delivery Au nanorods (AuNRs) to intratumor. (vinastemcelllab.com)
Then Yanlie's team tested migration capacity of AuNRs-iPS cells to target the tumor site in the mice by photoacoustic imaging and two-photon fluorescent microscope observation of tumor sections. (vinastemcelllab.com)
On the cellular level, plasma effects include detachment of cells from the extracellular matrix and decreased migration velocity of cells. (nature.com)
The four peptides efficiently inhibited CXCL12-dependent migration at concentrations as low as 10 nM and delayed CXCL12-mediated wound healing in PES43 human melanoma cells. (cnr.it)

Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
Dr. Canter's group is one of a select group of labs internationally who are studying dog NK cells, and they have completed a first-in-dog clinical trial of palliative radiation with intra-tumoral NK cells for dog with naturally-occurring osteosarcoma. (ucdavis.edu)
The clinical data indicate that praziquantel could greatly enhance the anticancer efficacy of Taxol in various cell lines including Taxol resistant cell lines. (thehealthyplanet.com)
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. (biomedcentral.com)
The rapid advance of stem cell clinical trials for a broad spectrum of conditions warrants an update of the review by Trounson (2009) [ 1 ]. (biomedcentral.com)

Targeting Chemoresistant Tumors: Could TRIM Proteins-p53 Axis Be a Possible Answer? (mdpi.com)
Bortezomib Augments Natural Killer Cell Targeting of Stem-Like Tumor Cells. (ucdavis.edu)

ImmunoCult™-XF T Cell Expansion Medium is a serum-free and xeno-free medium optimized for the in vitro culture and expansion of human T cells isolated from peripheral blood. (stemcell.com)

Brain tumor stem cells (orange) in mice express a stem cell marker (green). (medicalxpress.com)
After iPS cells were incubated with these special nanoparticles , AuNRs-iPS cells were injected to female BALB/c athymic nude mice tumor model. (vinastemcelllab.com)
In addition, the mice model treated with AuNRs-iPS decreased the tumor weight, total protein harvested from tumor and improved histopathology. (vinastemcelllab.com)

To test this hypothesis, Dr. Vasko, along with scientists from the CRTRC Institute for Drug Development in San Antonio and from the Johns Hopkins University, set out to measure both stem cells markers and tumor volume before and after treatment in a mouse model. (medindia.net)

Loss‑of‑function NOTCH1 mutations are early events during esophageal tumorigenesis, whereas gain‑of‑function NOTCH1 mutations are late events during T‑cell leukemogenesis and B‑cell lymphomagenesis. (spandidos-publications.com)

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. (edu.au)

Anatomy38

Organisms13

Diseases41

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment63

Phenomena and Processes51

Disciplines and Occupations4

Technology, Industry, Agriculture2

Information Science3

Health Care5

Solid tumors7

Microenvironment6

Malignant10

Metastasis14

Cancers16

Proliferation8

Targeted therapy1

Progression11

Brain tumors8

Recurrence3

Growth20

Embryonic stem3

Therapies9

Angiogenesis1

Survival7

Chemotherapy9

Anti-tumor1

Therapeutic12

Breast cancer18

Tissue9

CSCs10

Cancer74

Metastatic tumors1

Autologous2

Fibroblasts1

Mesenchymal10

Malignancies2

Therapeutics3

Biology4

Vivo4

Immune6

Hematopoietic Stem Cell Trans1

Patients8

Benign2

Apoptosis4

Mechanisms1

Genes1

Macrophages4

Bone2

Malignancy1

Induce1

Epithelial2

Lung2

Head and neck2

Mammary stem cells1

Transplantation2

Prostate1

Migration4

Clinical5

Targeting2

Vitro1

Mice3

Markers1

Mutations1

Differentiation1