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  • immunity
  • Phosphorylation plays a critical cellular role, and deregulation in phosphate metabolism is associated with disease, including autoimmunity and tumor immunity. (pnas.org)
  • We have solved the high-resolution structures of 3 HLA A2-restricted phosphopeptides associated with tumor immunity and compared them with the structures of their nonphosphorylated counterparts. (pnas.org)
  • Human MHC class I-restricted CD4+ T cells specific for Epstein-Barr Virus and Cytomegalovirus provide protective immunity in vivo. (royalfree.nhs.uk)
  • 1) Molecular and cellular biophysics of human innate immunity, with a focus on the pleiotropic roles of host defense peptides and amyloidogenic peptides in human health and disease, including infectious disease, cancer, and plaque diseases. (stanford.edu)
  • The described procedure resembles approaches of tolerance induction used decades ago, induces tolerance in the absence of immunity, and holds the promise to become an effective means of inducing antigen-specific tolerance prospectively, whereas its power to suppress already ongoing immune responses remains to be determined. (rupress.org)
  • It was our interest to develop a protocol suitable to generate CD25 + Foxp3 -expressing regulatory T cells with defined Ag specificity in vivo with the goal of generating Ag-specific tolerance in the absence of concomitant immunity in the fully mature immune system. (rupress.org)
  • recognition
  • These results indicate that Id-peptide-based recognition of MM-released exosomes may represent a very sensitive diagnostic approach for clinical evaluation of disease progression. (biomedcentral.com)
  • The immune system has evolved to survey changes in phosphorylation through the action of both innate and adaptive effector pathways that include specific recognition of phosphoantigens. (pnas.org)
  • presented by HLA-A2 in different types of tumor cell lines for CTL recognition. (clinicaltrials.gov)
  • Pharmacologic inhibition of MAPK signaling also led to improved peptide/MHC target recognition and killing by T cells and TCR-mimic antibodies. (nih.gov)
  • The 14 amino acid sequence (aa 450-463 ) TKDNNLLGRFELSG (TKD) of heat shock protein 70 (Hsp70) was identified as a tumor-selective recognition structure for natural killer (NK) cells. (aacrjournals.org)
  • lymphocytes
  • In this report, we demonstrate that the interaction of epithelial cell marker E-cadherin with integrin α E (CD103)β 7 , often expressed by tumor-infiltrating lymphocytes (TILs), plays a major role in effective tumor cell lysis. (rupress.org)
  • Thus, CD8 + /CD103 + tumor-reactive T lymphocytes infiltrating epithelial tumors most likely play a major role in antitumor cytotoxic response through α E β 7 -E-cadherin interactions. (rupress.org)
  • These tumors are often infiltrated by TCR-α/β + , CD8 + , and CD28 − T lymphocytes, and tumor-specific CTLs with high functional avidity were found to be selectively expanded at the tumor site, suggesting that they may contribute to control of the tumor ( 8 ). (rupress.org)
  • We previously isolated, from lymphocytes infiltrating an MHC-I low /ICAM-I − LCC and autologous PBL, two tumor-specific T cell clones expressing a unique TCR and displaying a CD8 + /CD28 − /CD27 − /CD45RA + /CD62L − /CCR7 − terminally differentiated effector phenotype ( 9 ). (rupress.org)
  • stimulation
  • and by being taken up by DCs together with the peptides, PEI enhanced the stimulation of DCs and the ensuing tumor-directed cytotoxic T cell responses in our mouse models," said first-author Aileen Li, Ph.D., who performed her graduate work with Mooney and now is a Postdoctoral Fellow at the University of California San Francisco. (harvard.edu)
  • Glioma
  • Here, we report that tandem nanomicelles co-functionalized with brain tumor-targeting and cell-penetrating peptides, Angiopep-2 and TAT, enable a highly efficacious and specific anti-glioma chemotherapy. (ovid.com)
  • We further show that docetaxel-loaded tandem nanomicelles have a long blood circulation time in mice and significantly better inhibit orthotopic U87MG human glioma than the corresponding Angiopep-2 single peptide-functionalized control, leading to an improved survival rate with little adverse effects. (ovid.com)
  • These tandem nanomicelles uniquely combining brain tumor-targeting and cell-penetrating functions provide a novel and effective strategy for targeted glioma therapy. (ovid.com)
  • ovarian
  • Synthetic peptide analogues of sequences in the HER-2 protooncogene (HER-2) were selected based on the presence of HLA-A2.1 anchor motifs to identify the epitopes on HER-2 recognized by ovarian tumor-reactive CTL. (rupress.org)
  • This peptide was specifically recognized by cloned CD8+ CTL isolated from one of the ovarian-specific CTL lines. (rupress.org)
  • E75-pulsed T2 cells inhibited lysis by the same CTL clone of both an HLA-A2+ HER-2high ovarian tumor and a HER-2high cloned ovarian tumor line transfected with HLA-A2, suggesting that this or a structurally similar epitope may be specifically recognized by these CTL on ovarian tumors. (rupress.org)
  • infusion
  • Interleukin -2 (IL-2) is administered as a continuous intravenous (IV) infusion for 4 days/week for 3 successive weeks starting on the same day as T cell /peptide-pulsed infusions. (clinicaltrials.gov)
  • mutation
  • Tumor tissue availability for determination of Von Hippel-Lindau (VHL) mutation (paraffin block, or fresh tissue). (knowcancer.com)
  • In some cases, overexpression of p53 protein could also occur in tumors without detectable mutation in the open reading frame. (clinicaltrials.gov)
  • monoclonal antibody
  • This cell killing is abrogated after treatment of the TIL clones with a blocking anti-CD103 monoclonal antibody or after targeting E-cadherin in the tumor using ribonucleic acid interference. (rupress.org)
  • diagnosis
  • Tumor-derived exosomes (TDEs) play a pivotal role in tumor establishment and progression, and are emerging biomarkers for tumor diagnosis in personalized medicine. (biomedcentral.com)
  • Thus the Candida specific PCR may be an excellent tool for early diagnosis of deep mycosis clinically and for further understanding of fungal translocation. (nii.ac.jp)
  • complexes
  • This article highlights our recent achievements on the development and upgrade of new potential tumor-specific contrast agents for magnetic resonance imaging (MRI) based on gadolinium complexes and peptides, assemblied in amphiphilic supramolecular aggregates. (lu.se)
  • progression
  • By FACS, the FITC-conjugated Id-peptides detected the MM-released exosomes in the serum of 5T33MM-engrafted mice, levels of which are correlated with tumor progression at an earlier time point compared to serum paraprotein. (biomedcentral.com)
  • mechanisms
  • thus, the mechanisms underlying tumor metastasis and growth in gastric cancer need to be extensively explored. (springer.com)
  • clinically
  • Raising the strategy's clinical potential, these advances also translated to mouse models with clinically more relevant tumors that the researchers investigated with a collaborating team lead by Kai Wucherpfennig, M.D., Ph.D., Chair of the Dana-Farber Cancer Institute's Department of Cancer Immunology and Virology. (harvard.edu)