• MicroRNAs (miRNAs) are small noncoding RNA molecules that post-transcriptionally regulate gene expression. (oncotarget.com)
  • High expression of one of these five miRNAs, miR-652, correlated significantly with an increased rate of prostate cancer biochemical recurrence. (oncotarget.com)
  • MicroRNAs (miRNAs) play important roles in the initiation and progression of NSCLC. (ajmb.org)
  • Small non-coding RNAs (sncRNAs) mainly consist of microRNAs (miRNAs) and small nucleolar RNAs (snoRNAs) 8 . (ajmb.org)
  • miRNAs can post-transcriptionally regulate the expression of myriad of different target genes including more than 30% of protein coding genes 9 , thereby managing an extensive spread of biological functions such as cellular proliferation 10 , apoptosis 11 and differentiation 12 . (ajmb.org)
  • miRNAs may function as tumor suppressors or oncogenes, thus dysregulated expressions participate in cancer development and progression 16,17 . (ajmb.org)
  • MicroRNAs (miRNAs) are small, endogenous noncoding RNAs composed of 18-23 nucleotides (nt) that post-transcriptionally regulate gene expression by targeting the 3'-untranslated regions of mRNAs [ 1 - 3 ]. (biomedcentral.com)
  • MicroRNAs (miRNAs) are well-recognized for their abilities to regulate gene expression post-transcriptionally in plants and animals. (frontiersin.org)
  • The expressions of candidate miRNAs and mRNAs were determined by real-time quantitative PCR(RT-qPCR) in MC3T3-E1 cells. (frontiersin.org)
  • MicroRNAs (miRNAs) are short non-coding RNAs that posttranscriptionally regulate gene expression inside the cell. (frontiersin.org)
  • This review focuses on the mechanisms by which vesicle-free miRNAs are secreted from neuroendocrine cells and will discuss potential functions of vesicle-free miRNAs and how vesicle-free miRNAs regulate cell-to-cell communication. (frontiersin.org)
  • tRNA and rRNA are dominant ncRNAs, miRNAs have critical functions in gene expression. (frontiersin.org)
  • 60% of human protein-coding genes, mostly by binding to the 3′- untranslated region (3′UTR) of the target mRNAs ( 5 ) and, therefore, miRNAs affect gene expression networks of a variety of biological processes including development, apoptosis, proliferation, and metabolism ( 1 , 2 ). (frontiersin.org)
  • and (3) the level of tumor-derived extracellular miRNAs might vary with the age of the patient and the status of disease, so their value as non-invasive biomarkers are reduced. (frontiersin.org)
  • RNA polymerase II mainly transcribes microRNA genes as primary miRNA transcripts (pri-miRNAs) that contain 5′cap and 3′poly(A) tails ( 28 ). (frontiersin.org)
  • Drosha, RNase III, and DGCR8, the RNA-binding protein, further process pri-miRNAs into stem-loop structured precursor miRNAs (pre-miRNAs) of ~70 nt ( 29 ). (frontiersin.org)
  • After pre-miRNAs are transported to the cytoplasm, RNase III Dicer and TRBP (transactivation-response RNA-binding protein) cleave them into double-stranded miRNA duplexes of ~22 nt ( 30 , 31 ). (frontiersin.org)
  • MicroRNAs (miRNAs) are endogenous short non-coding RNA molecules that can post-transcriptionally regulate gene expression and play a critical role in gonadal differentiation as well as early development of animals. (peerj.com)
  • Research on the sex-biased expression of miRNAs in avian gonads are limited, and little is known about M. undulatus . (peerj.com)
  • In conclusion, this work is the first report of sex-biased miRNAs expression in the budgerigar, and provides additional sequences to the avian miRNAome database which will foster further functional genomic research. (peerj.com)
  • MicroRNAs (miRNAs) are all non-coding RNAs that play vital role in post-transcriptional regulation of various animals and plants ( Bartel, 2009 ). (peerj.com)
  • MicroRNAs (miRNAs) are short non-coding RNAs that have been termed "master regulators of the genome" given their significance in post-transcriptional gene regulation, and roles in a multitude of normal and disease processes. (amegroups.org)
  • In cancer, dysregulation of miRNAs can facilitate disease progression and therapeutic resistance, affecting tumour-suppressors and oncogenes. (amegroups.org)
  • MicroRNAs (miRNAs) are short non-coding RNAs, typically 21-23 nucleotides long, that function in post-transcriptional gene regulation typically through translation inhibition and/or mRNA degradation ( 1 ). (amegroups.org)
  • Since their discovery in Caenorhabditis elegans , miRNAs have been extensively investigated as master regulators of gene expression in a variety of animal, plant, and human models. (amegroups.org)
  • MiRNA expression is frequently altered during cancer development, associated with dysregulated expression of a plethora of different miRNAs, their biogenesis or processing proteins, such as DROSHA and DICER1 ( 1 ). (amegroups.org)
  • In recent years, emerging studies have highlighted the critical role of these pathways and their regulation by microRNAs (miRNAs) in cancer invasion and metastasis. (intechopen.com)
  • MiRNAs, short (18-24 nucleotides) non-coding RNAs, are derived from long transcripts pri-miRNAs and pre-miRNAs [ 26 - 30 ].By targeting 3' untranslated regions (3'UTRs) of cognate mRNAs, miRNAs post-transcriptionally regulate gene expression and induce translational repression [ 29 , 30 ]. (intechopen.com)
  • To date, 1527 human miRNAs have been identified (Sanger miRBase 18 http://www.miRbase.org/index.shtml), forming less than 1% of all human genes, potentially regulating more than 10% of all protein coding genes [ 1 ]. (intechopen.com)
  • EBV is the first human virus that has the capability to encode microRNAs (miRNAs). (ijbs.com)
  • EBV miRNAs also inhibit the expression of viral antigens, thereby enabling infected cells to escape immune recognition. (ijbs.com)
  • microRNAs (miRNAs) are a large class of small non-coding RNAs with a length of 21-23 nucleotides (nt) [ 11 ]. (ijbs.com)
  • Exceptionally, a minority of miRNAs are derived from RNA Pol III transcripts. (ijbs.com)
  • For example, murine gammaherpesvirus 68 (MHV-68)-encoded miRNAs are located downstream of viral tRNAs and transcribed by RNA Pol III [ 2 ]. (ijbs.com)
  • miRNAs are able to post-transcriptionally control gene expression by binding to target mRNAs [ 15 ]. (ijbs.com)
  • Colorectal cancer Core tip: MicroRNAs (miRNAs), a key class of gene ex-pression regulators, have emerged as crucial players in various biological processes such as cellular prolifera-tion and differentiaprolifera-tion, development and apoptosis. (123dok.net)
  • In the case of RNA molecules that bind target RNA segments, such as microRNAs (miRNAs), the altered base pairing can change binding specificities. (biomedcentral.com)
  • Model based on GA and DNN for prediction of mRNA-Smad7 expression regulated by miRNAs in breast cancer. (cancerindex.org)
  • miRNAs regulate proteins expressions by arresting or degrading the mRNAs. (cancerindex.org)
  • Although multiple RNA binding proteins and microRNAs (miRNAs) have been reported to promote EMT progression in solid tumors [ 22 , 23 ], the roles and the underlying mechanisms of these post-transcriptional regulators have not been intensively investigated in mediating extramedullary metastasis of AML. (biomedcentral.com)
  • The development, cell fate, patterning, and innervation of both the sensory and nonsensory regions of the inner ear are governed by tight regulation involving, among others, transcription factors and microRNAs (miRNAs). (biomedcentral.com)
  • NGS of RNA from inner ear sensory epithelial cells led to the identification of 455 miRNAs in both cochlear and vestibular sensory epithelium, with 30 and 44 miRNAs found in only cochlea or vestibule, respectively. (biomedcentral.com)
  • The results provide further support of the essential regulatory role of miRNAs in inner ear sensory epithelia and in regulating pathways that define development and growth of these cells. (biomedcentral.com)
  • miRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally. (biomedcentral.com)
  • We further validated and characterized the expression of two miRNAs, miR-6715-3p and miR-6715-5p, in the mouse inner ear. (biomedcentral.com)
  • Gene expression, Kaplan-Meier survival, microRNA and transcription factor target analyses were performed with the University of Alabama Cancer (UALCAN) Database, Kaplan-Meier Plotter, LinkedOmics, WebGestalt and gene set enrichment analysis, respectively. (xiahepublishing.com)
  • Gene Ontology and pathway enrichment analyses and assessment of RNA binding proteins were performed by R software, circlncRNAnet and Encyclopedia of RNA Interactomes (ENCORI). (xiahepublishing.com)
  • These are responsible for abnormal gene expression, resulting in increased cancer cell proliferation and escape from immune surveillance, which can speed up the process of development into HCC. (xiahepublishing.com)
  • The Cancer Genome Atlas (TCGA) database has accumulated abundant genomic and gene expression profiles for different diseases in the past decade. (xiahepublishing.com)
  • Some snoRNAs could be processed to produce molecules like miRNA which drive post-translational gene silencing on complementary mRNAs 20-22 . (ajmb.org)
  • An MC3T3-E1-based microarray dataset (accessioned as GSE46400) downloaded from the Gene Expression Omnibus included MC3T3-E1 cells with or without 14-day osteoblast differentiation osteoblast induction. (frontiersin.org)
  • in this way, vesicle-free miRNA may regulate cell-to-cell communication including the regulation of gene expression and cellular signaling. (frontiersin.org)
  • Until recently, it was unknown how sexual differences in the behavior, physiology, and development of organisms are regulated by differential gene expression. (peerj.com)
  • In this regard, the inflammasomes have been identified as an innate immune sensor toward pathologic external factors as well as endogenous damage-associated molecular pattern signals transducing from the above-mentioned receptors to gene expressions. (biomedcentral.com)
  • MicroRNAs, a key class of gene expression regulators, have emerged as crucial players in various biological processes such as cellular proliferation and differentia-tion, development and apoptosis. (123dok.net)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Treatment of CRC cells with MS-444 resulted in growth inhibition and increased apoptotic gene expression, while similar treatment doses in non-transformed intestinal cells had no appreciable effects. (oncotarget.com)
  • Expression of this gene is induced by TGFBR1. (cancerindex.org)
  • The miRNA-mRNA profiles and bioinformatics study suggested that the SFRP1 gene was potentially regulated by miRNA-1/206 during porcine skeletal muscle development. (biomedcentral.com)
  • Our results indicate that the SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development. (biomedcentral.com)
  • Stress-induced changes of gene expression are crucial for survival of eukaryotic cells. (prolekarniky.cz)
  • Cells maintain their internal homeostasis by adequate reprogramming of metabolic activities at all levels of gene expression, including chromatin remodeling, mRNA expression and degradation, translation and protein degradation. (prolekarniky.cz)
  • Moreover, after 1,25(OH) 2 D 3 treatment the gene expression in several cancer-related processes was down-regulated. (biomedcentral.com)
  • Adding microRNA regulation to the network enabled the identification of gene targets of significantly expressed microRNAs after 1,25(OH) 2 D 3 treatment. (biomedcentral.com)
  • Integrating the effects of nutritional compounds at the gene expression level with information about the regulatory level can shed a new light on their action mechanism. (biomedcentral.com)
  • Promising regulatory molecules in this respect are small non-coding RNAs, like microRNAs, which regulate gene expression post-transcriptionally. (biomedcentral.com)
  • 2011 ) clearly showed that 1,25(OH) 2 D 3 can modulate gene and microRNA profiles in LCNaP cells and affects processes involved in cell cycle arrest, calcium ion homoeostasis and phosphoinositide-mediated signalling. (biomedcentral.com)
  • In the Gene Expression Omnibus (GEO, http://ncbi.nlm.nih.gov/geo/ , Barrett and Edgar 2006 ), we found two studies in which global gene expression was measured in 1,25(OH) 2 D 3 -treated prostate cells, accession numbers: GSE17461 and GSE15947. (biomedcentral.com)
  • NcRNAs play a significant role in regulating gene expression in digestive system tumors. (ijbs.com)
  • We showed previously that cytoplasmic release of mtDNA activates the cGAS STING TBK1 pathway resulting in interferon-stimulated gene (ISG) expression that promotes antiviral immunity4. (regenerativemedicine.net)
  • Here, we find that persistent mtDNA stress is not associated with basally activated NF-κB signalling or interferon gene expression typical of an acute antiviral response. (regenerativemedicine.net)
  • We found that miR-652 directly targets the B" regulatory subunit, PPP2R3A, of the tumor suppressor PP2A, inducing epithelial-mesenchymal transition (EMT) in PC3 cells and neuroendocrine-like differentiation (NED) in LNCaP cells. (oncotarget.com)
  • The tumor suppressor TP53 (also called p53) has been among the most extensively studied genes since its discovery in 1979 [ 1 , 2 ]. (nature.com)
  • However, the debate regarding which single function of p53 is absolutely critical for its tumor suppressor role is ongoing [ 7 ]. (nature.com)
  • We recently found low level of tumor suppressor programmed cell death 4 (PDCD4) associated with reduced atherosclerotic plaque area (unpublished). (plos.org)
  • Programmed cell death 4 (PDCD4) is an important tumor suppressor in the development of various human cancers [1] and inhibits translation rather than transcription. (plos.org)
  • They use their complex epigenetic regulatory mechanisms to act as upstream regulators of downstream oncogenes or tumor suppressor genes [ 10 ]. (ijbs.com)
  • Long non-coding RNA small nucleolar RNA host genes (SNHGs) play a critical role in the occurrence and development of tumors. (xiahepublishing.com)
  • It regulates Sp7 protein expression and induces expression of major bone matrix protein genes, such as Col1a1, Spp1, Ibsp, Bglap2, and Fn1 ( 7 , 8 ). (frontiersin.org)
  • The AU-rich element RNA-binding protein 1 (AUF1) is an RNA-binding protein, which can both stabilize and destabilize the transcripts of several cancer-related genes. (nature.com)
  • Four latency types (0, I, II, III) are defined depending on the expression pattern of EBV latent genes, and at the same time are linked to a particular tumor type [ 6 , 7 ]. (ijbs.com)
  • ADARs have been shown to contribute to disease pathologies by editing of glutamate receptors, editing of serotonin receptors, mutations in ADAR genes, and by other mechanisms, including recently identified regulatory roles in microRNA processing. (biomedcentral.com)
  • It is therefore conceivable that the inhibition of the function of these genes may specifically affect the proliferation and survival of brain tumor cells. (cancerindex.org)
  • Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, TNFα and VEGF. (oncotarget.com)
  • Overexpression of the RNA-binding protein HuR (ELAVL1) occurs during colon tumorigenesis and is abnormally present within the cytoplasm, where it post-transcriptionally regulates genes through its interaction with 3'UTR AU-rich elements (AREs). (oncotarget.com)
  • The changes in the G1-to-S cell cycle pathway showed that 1,25(OH) 2 D 3 down-regulates the genes influencing the G1-to-S phase transition. (biomedcentral.com)
  • Six of the nine differentially expressed microRNAs target genes in the extended network, including CLSPN , an important checkpoint regulator in the cell cycle that was down-regulated, and FZD5 , a receptor for Wnt proteins that was up-regulated. (biomedcentral.com)
  • Functional enrichment analysis revealed SNHG4 involvement with regulation of ribosomal RNA synthesis and the RNA processing and surveillance pathway. (xiahepublishing.com)
  • Ferroptosis acts as an independent pathway for suppressing tumor growth and is tightly connected with metabolism and oxidative stress responses. (nature.com)
  • In order to identify the target molecule of miRNA-1908, a luciferase reporter assay was performed, and the corresponding downstream signaling pathway was examined using immunohistochemistry of human glioblastoma tissues. (biomedcentral.com)
  • In a cytokine profile analysis of familial Mediterranean fever patients, we have found that interleukin-6 is considered to be one of the most crucial cytokines in familial Mediterranean fever attack since interleukin-6 had the best performance for distinguishing familial Mediterranean fever in attack from healthy controls or familial Mediterranean fever in remission, and in vitro interleukin-6 production is regulated by microRNAs-204-3p/phosphoinositide 3-kinase g pathway. (biomedcentral.com)
  • MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7. (cancerindex.org)
  • Based on the findings, the inhibition of miR-543 was found to play a tumor suppressive role in PA through the down-regulation of Wnt/β-catenin pathway by negatively regulating Smad7. (cancerindex.org)
  • The SFRPs inhibit Wnt receptor binding to down-regulate pathway signaling during development [ 8 ]. (biomedcentral.com)
  • The present study demonstrates how pathway analysis can be combined with network analysis to perform an integrated analysis of transcriptomics and microRNA-omics data. (biomedcentral.com)
  • In the present study, we will combine pathway- and network-based methods to decipher the regulatory action of 1,25(OH) 2 D 3 in prostate cancer cells on mRNA and microRNA level. (biomedcentral.com)
  • NcRNAs are a class of RNA molecules that do not encode proteins, and they play an important role in regulating cellular transcription and post-transcriptional processes [ 7 ]. (ijbs.com)
  • Although RNA editing has long been considered a relatively rare processing event, more recent research suggests that the vast majority of pre-mRNAs are edited [ 6 ]. (biomedcentral.com)
  • Mechanistically, MS-444 disrupted HuR cytoplasmic trafficking and released ARE-mRNAs for localization to P-bodies, but did not affect total HuR expression levels. (oncotarget.com)
  • MiR-652 may contribute to prostate tumor progression by promoting NED through decreased PP2A function. (oncotarget.com)
  • Although PDCD4 in general suppresses the development and progression of tumors, its specific biological functions differ by cell type [8] . (plos.org)
  • The previous studies have revealed that abnormal RNA-binding protein Musashi-2 (MSI2) expression is associated with cancer progression through post-transcriptional mechanisms, however mechanistic details of this regulation in acute myeloid leukemia (AML) still remain unclear. (biomedcentral.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Based on our findings, we infer SNHG4 may play a role in the formation of HCC via regulation of tumor-related pathways. (xiahepublishing.com)
  • Here, we review the role of ferroptosis in p53-mediated tumor suppression, with a focus on what cellular factors are critical for p53-dependent ferroptosis during tumor suppression and how p53 modulates both the canonical (GPX4-dependent) and the non-canonical (GPX4-independent) ferroptosis pathways. (nature.com)
  • The initiation and development of tumor cell is accompanied by elevated stresses, such as oncogene activation, DNA damage, genome instability, and reprogrammed tumor metabolism. (nature.com)
  • Eukaryotic RNA transcripts can undergo a range of post-transcriptional modifications, which increase the diversity of the transcriptome without requiring increases in genome size. (biomedcentral.com)
  • Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
  • Is p53-dependent ferroptosis sufficient for tumor suppression in the absence of cell cycle arrest, senescence, and apoptosis? (nature.com)
  • To date, various mechanisms have been suggested to explain the powerful tumor-suppressive effect of p53, including the induction of cell cycle arrest, senescence, and apoptosis. (nature.com)
  • Importantly, MS-444 was well tolerated and inhibited xenograft CRC tumor growth through enhanced apoptosis and decreased angiogenesis upon intraperitoneal administration. (oncotarget.com)
  • HP75 cells treated with overexpressed miR-543 exhibited increased cell proliferation, migration and invasion, while decreased cell apoptosis as well as expression of Cleaved caspase-3 and Cleaved caspase-8 were observed. (cancerindex.org)
  • Our aim was to investigate the role and mechanism of microRNAs in glioblastomas that could contribute to the diagnosis and prognostic evaluation of glioblastoma patients. (biomedcentral.com)
  • A-to-I editing is a mechanism that regulates and diversifies the transcriptome, but the full biological significance of ADARs is not understood. (biomedcentral.com)
  • Afterwards, the specific mechanism of miR-543 and Smad7 in PA were determined with the use of ectopic expression, depletion and reporter assay experiments. (cancerindex.org)
  • Objective To investigate the effects of microRNA-18a (miR-18a) on migration and invasion of hepatocellular carcinoma (HCC) cells, and its possible mechanism associated with Dicer l. (cams.cn)
  • Our study aimed to explore the relationship between microRNA-143 (miR-143) and MSI2 and to clarify their clinical significance, biological function and mechanism. (biomedcentral.com)
  • Therefore, we summarize the interrelation process between ncRNAs and methylation modifications in GI tumors, including the detailed mechanism of methylation enzyme regulation of ncRNAs, the molecular mechanism of ncRNAs regulation of methylation modifications, and the correlation between the interactions between ncRNAs and methylation modifications and clinical features of tumors. (ijbs.com)
  • p53's ability to inhibit tumors can be considered as a specific outcome of its stress-responsive effects. (nature.com)
  • It can also compete with eukaryotic translation initiation factor (eIF)4G and RNA for eIF4A binding and trap eIF4A in an inactive conformation to inhibit translation initiation via its two highly conserved MA3 domains [3] - [6] . (plos.org)
  • Moreover, luciferase reporter assay was used to identify whether Dicer expression was regulated by miR-18a. (cams.cn)
  • Effects of miR-143 on regulating MSI2 expression were investigated using luciferase reporter assay. (biomedcentral.com)
  • 98% of RNA transcripts in humans are non-coding ( 3 ). (frontiersin.org)
  • They are usually generated from either exons or introns of both protein-coding and non-coding transcripts that are processed by RNA polymerase II (Pol II) [ 12 - 14 ]. (ijbs.com)
  • A-to-I RNA editing is a post-transcriptional modification that converts adenosines to inosines in both coding and noncoding RNA transcripts. (biomedcentral.com)
  • In LNCaP cells and xenografted tumors, overexpression of miR-652 increased markers of NED, including chromogranin A, neuron specific enolase, and synaptophysin. (oncotarget.com)
  • The overexpression of miRNA-1908 significantly promoted anchorage-independent growth in vitro and significantly increased the tumor forming potential in vivo . (biomedcentral.com)
  • In the AML xenograft mouse model, overexpression of MSI2 recapitulated its leukemia-promoting effects, and overexpression of miR-143 partially attenuated tumor growth and prevented metastasis. (biomedcentral.com)
  • Ectopic expression of AUF1 also promoted stemness in mammary epithelial cells, and thereby increased the proportion of cancer stem cells. (nature.com)
  • EMT is an embryologically conserved genetic program by which epithelial cells down regulate intercellular tight junctions, loose polarity, express mesenchymal markers, and manifest a migratory phenotype [ 1 ]. (intechopen.com)
  • Recently, miRNA-messenger RNA (mRNA) regulatory relationships have been confirmed during biological processes, including osteogenic differentiation. (frontiersin.org)
  • Recently, new and unexpected functions of other types of small ncRNAs have been discovered and investigators found that snoRNA expression in cancers is as variable as miRNA expression 19 . (ajmb.org)
  • Recently, noncoding RNAs (ncRNAs) have been reported to regulate protein expression, and it is definite that PTEN expression is controlled by ncRNAs epigenetically or posttranscriptionally as well. (biomedcentral.com)
  • Herein, we provide a review on current understandings of the regulation of PTEN by ncRNAs, which could contribute to the development of novel approaches to the diseases with abnormal expression of PTEN. (biomedcentral.com)
  • Kong M, Yu X, Guo W, Guo R. The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors. (ijbs.com)
  • The aberrant expression of methylation and ncRNAs, two crucial regulators of epigenetic modifications, has been widely demonstrated in cancer. (ijbs.com)
  • Network algorithms were used to (1) identify active network modules and (2) integrate microRNA regulation in the network. (biomedcentral.com)
  • Their study in humans, however, has been hampered by the unavailability of inner ear RNA from human subjects, making the mouse an invaluable model for studying miRNA development and regulation in the inner ear [ 8 ]. (biomedcentral.com)
  • Measuring miRNA expression levels could provide a potential approach for the diagnosis of NSCLC. (ajmb.org)
  • The measurement of altered miRNA expression in sputum samples manifested the potential noninvasive approach for detection of lung cancer. (ajmb.org)
  • Scientific emerging evidences suggest the potential involvement of altered miRNA expressions in the pathogenesis of human cancers 13-15 . (ajmb.org)
  • We also investigated the miRNA-1908 expression in 34 patients according to the postoperative risk of recurrence. (biomedcentral.com)
  • Furthermore, the expression levels of miRNA-1908 were significantly increased in the patients with a high risk of recurrence compared to that observed in the low-risk patients, and this higher expression correlated with a poor survival. (biomedcentral.com)
  • MicroRNA-1/206(miRNA-1/206) is specifically expressed in skeletal muscle and play a critical role in myogenesis. (biomedcentral.com)
  • We performed a temporal-spatial expression analysis of SFRP1 mRNA and miRNA-206 in Tongcheng pigs (a Chinese indigenous breed) by quantitative real-time polymerase chain reaction, and conducted the co-expression analyses of SFRP1 and miRNA-1/206. (biomedcentral.com)
  • RNA editing refers to post-transcriptional processes that alter the nucleotide sequence of an RNA transcript by insertion, deletion or nucleotide conversion. (biomedcentral.com)
  • Therefore PTEN might be a biomarker for various diseases, and targeting the abnormal expression level of PTEN is anticipated to offer novel therapeutic avenues. (biomedcentral.com)
  • Here, we examine the therapeutic potential of targeting HuR using MS-444, a small molecule HuR inhibitor. (oncotarget.com)
  • Therefore, understanding the pathogenesis of cancer, identifying biomarkers that aid in the early diagnosis of digestive tract tumors, and finding therapeutic targets are of great significance in reducing the incidence of digestive tract tumors and improving prognosis. (ijbs.com)
  • microRNA-18a Promotes Cell Migration and Invasion Through Inhibiting Dicer l Expression in Hepatocellular Carcinoma In Vitro △ [J].Chinese Medical Sciences Journal, 2017, 32(1): 34-43. (cams.cn)
  • In the current study, we sequenced two small non-coding RNA libraries made from the gonads of adult male and female budgerigars using Illumina paired-end sequencing technology. (peerj.com)
  • Furthermore, suppression of Dicer l expression by small interfering RNA essentially abolished the inhibition of cell migration and invasion induced by miR-18a inhibitor, restorating these activities to levels similar to the parental HCC cells. (cams.cn)
  • MicroRNAs are a class of small, single-stranded, noncoding RNA (~21-24 nt in length) that occur in the genomes of plants and animals. (biomedcentral.com)
  • MiR-652 expression could serve as a biomarker for aggressive prostate cancer, as well as provide an opportunity for novel therapy in prostate cancer. (oncotarget.com)
  • ADAR3 contains an arginine-rich domain, shown in pink, which binds single-stranded RNA. (biomedcentral.com)
  • Transfer RNAs (tRNAs) enter ribosome-mediated protein biosynthesis in a translationally competent state, which includes post-transcriptional modifications at various positions, including the anticodon loop, and the presence of an intact single-stranded CCA-sequence at the 3′-terminus that is required for amino acid attachment by the corresponding aminoacyl-tRNA-synthetase [7] . (prolekarniky.cz)
  • Moreover, AKT signaling contributes to oncogenesis through activating multiple downstream effector molecules. (biomedcentral.com)
  • But the potential role of miR-1908 in the carcinogenesis and tumor development of glioblastoma is unknown. (biomedcentral.com)
  • In this review, we discuss our current understanding of microRNAs with a focus on their role and mode of action in regulating the immune system during inflammation and carcinogenesis. (123dok.net)
  • In this study, we demonstrate that exposure to oxidative stress results in a quick repression of translation by deactivation of the aminoacyl-ends of all transfer-RNA (tRNA). (prolekarniky.cz)
  • Expression of SNHG4 in HCC is higher in HCC tissue than in normal healthy liver tissues and is mainly distributed in the nucleus. (xiahepublishing.com)
  • Can ferroptosis be specifically induced in tumors but not in normal tissues? (nature.com)
  • A-to-I editing, which is catalyzed by enzymes of the adenosine deaminase acting on RNA (ADAR) family, is most prevalent in the central nervous system (CNS) but occurs in many tissues [ 1 - 3 ]. (biomedcentral.com)
  • Up-regulated miR-543 and downregulated Smad7 were observed in PA tissues. (cancerindex.org)
  • The expression level of the SFRP1 was highly varied across numerous pig tissues and it was down-regulated during porcine skeletal muscle development. (biomedcentral.com)
  • Wang M, Yu F, Wu W, Wang Y, Ding H, Qian L. Epstein-Barr virus-encoded microRNAs as regulators in host immune responses. (ijbs.com)
  • In addidifferentia-tion, microR-NAs are coming to light as crucial regulators of innate and adaptive immune responses, and their abnormal expression and/or function in the immune system have been linked to multiple human diseases including inflammatory disorders, such as inflammatory bowel disease, and cancers. (123dok.net)
  • In vivo treatment of MS-444 inhibited HuR cytoplasmic localization and decreased COX-2 expression in tumors. (oncotarget.com)
  • Tumors with increased NED are more aggressive and correlate with poor prognosis [ 2 - 4 ]. (oncotarget.com)
  • U2 auxiliary factor 2 (U2AF2) showed strong correlation with SNHG4 , while low-expression of U2AF2 showed good prognosis. (xiahepublishing.com)
  • Notably, low expression of miR-143, and high expression of MSI2 were associated with poor prognosis in AML patients. (biomedcentral.com)
  • Accumulating data have confirmed that high expression of Msi2 mRNA is associated with poor prognosis in AML, as patients with as low as 1% of total bone marrow cells expressing elevated MSI2 levels still have a short survival [ 14 , 15 ]. (biomedcentral.com)
  • The complex interplay between them is essential in promoting malignant phenotype, poor prognosis, and drug resistance in GI tumors (including esophageal, gastric, colorectal, liver, and pancreatic cancers). (ijbs.com)
  • In addition to their high incidence, the prognosis for digestive system tumors is often poor [ 3 ]. (ijbs.com)
  • A critical requirement for developing such agents is to identify druggable targets required for the proliferation or survival of tumor cells, but not of other cell types. (cancerindex.org)
  • Importantly, breast cancer cells that ectopically express AUF1 were more efficient in forming orthotopic tumor xenografts in nude mice than their corresponding controls with limiting cell inocula. (nature.com)
  • Finally, based on these mechanisms, we discuss treatments that could increase the survival of older people, not simply by inhibiting the virus, but by restoring patients' ability to clear the infection and effectively regulate immune responses. (aging-us.com)
  • PTEN also dephosphorylates Src homology 2-containing protein (Shc) directly, and inhibits the activation of Shc/Raf/ERK1/2 (extracellular signal-regulated kinase) signaling cascade. (biomedcentral.com)
  • Osterix (OSX) is a transcription factor in the SP family, which is essential for osteoblast differentiation, and its expression is closely related to Runx2 ( 9 ). (frontiersin.org)
  • Hepatocellular carcinoma (HCC), which represents about 85-90% of cases of primary liver cancer, is the fourth most common malignancy and the third leading cause of tumor-related deaths in China. (xiahepublishing.com)
  • Our goals were to examine miR-223, miR-212, miR-192, miR-3074, SNORD33 and SNORD37 expression levels in tissue and sputum of NSCLC patients and cancer free subjects for molecular diagnosis of NSCLC. (ajmb.org)
  • PTEN expression alteration is crucial to the pathogenesis of cancer and other diseases. (biomedcentral.com)
  • Thereby, AUF1 targeted molecules could constitute efficient therapeutics for breast cancer patients. (nature.com)
  • Cancer cells depart their normal microenvironment from the primary tumor site through complicated and multistep processes disseminate and colonize distant organs [ 1 ]. (intechopen.com)
  • In this study, we performed an integrative network-based analysis using a publicly available data set studying the role of 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) in prostate cancer cells on mRNA and microRNA level. (biomedcentral.com)
  • The extendable network-based tools PathVisio and Cytoscape enable straightforward, in-depth and integrative analysis of mRNA and microRNA expression data in 1,25(OH) 2 D 3 -treated cancer cells. (biomedcentral.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • p53-mediated ferroptosis is required for its tumor suppression in mouse models. (nature.com)
  • What is the physiological ferroptosis inducer(s) for p53 during tumor suppression? (nature.com)
  • Interestingly, suppression of miR-18a in HCC cells resulted in enhanced expression of Dicer l. (cams.cn)
  • Conclusion Our findings suggest that miR-18a promotes migration and invasion of HCC cells by inhibiting Dicer l expression. (cams.cn)
  • Reducing miR-18a expression degrades migration and invasion of HCC cells. (cams.cn)
  • Real-time RT-PCR and western blot were performed to analyze Dicer 1 expression. (cams.cn)
  • Scheme of putative microRNA-18a (miR-18a) binding sites in the Dicer Ⅰ mRNA 3'-untranslated region (3'-UTR). (cams.cn)
  • miR-18a post-transcriptionally downregulates Dicer Ⅰ expression by directly targeting the Dicer Ⅰ mRNA 3′-UTR. (cams.cn)
  • It remains elusive, which alternative mechanisms the cell employs to regulate translation during adverse environmental stress. (prolekarniky.cz)
  • The RT-qPCR also determined declined expressions of miR-204-5p and miR-24-3p concomitant with elevated expressions of miR-211-5p, miR-3470b, miR-466b-3p, and miR-466c-3p in the MC3T3-E1 cells, with osteoblast induction compared with undifferentiated MC3T3-E1 cells. (frontiersin.org)
  • MiR-211-5p upregulation by its mimic increased Arhgap11a expression in MC3T3-E1 cells. (frontiersin.org)
  • We investigated whether atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells. (plos.org)
  • En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
  • In addition, they examined the expression of microRNAs in these cells upon treatment with 1,25(OH) 2 D 3 . (biomedcentral.com)
  • Most studies in the p53 field have focused on its roles in tumors. (nature.com)
  • Abnormal expression of miR-143 and MSI2 were evaluated in bone marrow samples from AML patients by quantitative real time-PCR. (biomedcentral.com)