Tumor replication through transcriptional. Medical search. Frequent questions

In pediatric solid tumors and brain tumors, PLK1 inhibition leads to apoptosis in vitro and in tumor xenografts. (childrenscolorado.org)
Despite success in blood cancers, CAR-T technology faces challenges in solid tumors, including lack of reliable tumor-associated antigens, hypoxic cores, immunosuppressive tumor environments, enhanced reactive oxygen species, and decreased T-cell infiltration. (bvsalud.org)
This review covers the evolution of CAR-T therapy against various tumors, including hematological and solid tumors, highlights challenges faced by CAR-T cell therapy, and suggests strategies to overcome these obstacles, such as utilizing single-cell RNA sequencing and artificial intelligence to optimize clinical-grade CAR-T cells. (bvsalud.org)
Hypoxia is a common feature of solid tumors and is associated with poor patient prognosis, therapy resistance and metastasis. (ox.ac.uk)

A popular of IRF acts CaM-dependent to be resting for recent, while TRAF3 contains characterized to be both IRF3 and post-transcriptional. (erik-mill.de)
11. Amsel, A. & Roussel, J. Motivational properties of ences in post-transcriptional processes spark interest in the development of frustration: I. Effect on a running response of the (protein redistribution, degradation), pharmacotherapies that selectively reg- addition of frustration to the motivational com- plex. (lu.se)

Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)

In other situations the response is cell cycle arrest or programmed cell death (apoptosis), providing a barrier to further tumour development that the tumour may ultimately circumvent through the acquisition of a mutation in one of the genes within the stress-response pathway. (southampton.ac.uk)
They are involved in a range of cellular processes, depending upon the transcriptional repressor that recruits them to DNA, and they suppress the transcription of genes that cause apoptosis (reviewed in Bergman et al, 2006a). (southampton.ac.uk)
The p53 tumour-suppressor guards the genome in response to genotoxic stress by transcriptional regulation of genes involved in cell-cycle control, DNA replication, repair and apoptosis such as p21, GADD45, bax and mdm2 (Cox and Lane, 1995). (hal.science)
I characterised the cellular effects of BET protein inhibition in pre-B ALL and showed this was associated with inhibition of cell cycle progression, downregulation of c-Myc protein, direct inhibition of DNA replication and induction of caspase-dependent apoptosis that was independent of p53 activity. (bham.ac.uk)

Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. (thermofisher.com)
Various studies have revealed the significance of USP37 in the regulation of replication stress and oncogenesis. (bvsalud.org)
However, transcriptional dynamic regulation of adipose differentiation driven by complex signal cascades remains largely unexplored in this model. (biomedcentral.com)

At that time, the application of tumor treatment with the spontaneous viruses or wild type viruses which quite often being scavenged by immune system, merely induces a subtle inhibition to tumor progression in patients. (biomedcentral.com)
The novel PLK1 inhibitor, onvansertib, is the first available for oral administration and has shown tumor growth inhibition in hematologic tumors, osteosarcoma, ovarian carcinoma, breast cancer and colon adenocarcinoma cells. (childrenscolorado.org)
Results obtained in our laboratory suggest that transcriptional upregulation of prosurvival pathways plays a key role in paediatric B-precursor ALL chemoresistance, thus providing a strong rationale for the inhibition of prosurvival gene transcription. (bham.ac.uk)
Using microarray technology I confirmed BET protein inhibition involves transcriptional downregulation of prosurvival pathways and identified potential biomarkers predictive of JQ1 sensitivity. (bham.ac.uk)

The Warburg phenotype provides tumors an enhanced resistance against cytotoxic insults. (springer.com)
MRs (sometimes also called tumor checkpoints in cancer) are genes that control the downstream pathways, and in cancer MRs "integrate" the effects of the mutations and alterations thereby resulting in a transformed phenotype. (cancerhealth.com)
I showed that BRD4 is ubiquitously expressed in paediatric ALL tumours and that treatment with the BET protein inhibitor JQ1 led to potent in vitro sensitisation of ALL tumour cells regardless of cellular phenotype, as well as in vivo sensitisation using xenograft models of ALL. (bham.ac.uk)
however, a comprehensive study of the phenotype, function, and transcriptional program of this T cell population in breast cancer (BC) patients is missing. (institut-curie.org)
When compared to blood counterparts, tumor-infiltrating senescent CD4+T cells show similar surface phenotype but reduced cytokine production. (institut-curie.org)

Various molecular assays, including colony formation, immunofluorescence, immunoprecipitation, and DNA replication restart, were employed to examine the physical interaction between USP37 and PCNA, as well as its physiological effects in osteosarcoma cells. (bvsalud.org)
Cell functional assays, in vivo xenografts tumor growth experiments, and survival analysis were used to investigate the functional significance and mechanism of chemosensitization after SETD8 downregulation. (biomedcentral.com)

Transcriptional responses to pathways: roles in the causes and treatment of cancer Intra-cellular stress-response pathways are activated in response to potentially deleterious conditions in the cell's environment. (southampton.ac.uk)
In single celled organisms these pathways are generally involved in ensuring the survival and replication of the individual cell. (southampton.ac.uk)
Stress-response pathways play a key role in the patho-physiology and treatment of many diseases, including cancer.At almost every stage of the development of a tumour, cells are exposed to some form of stress. (southampton.ac.uk)
Initiation and propagation of tumors reflect underlying genomic alterations such as mutations, polymorphisms, and copy number variations found in genes of multiple cellular pathways. (hindawi.com)
Senescent CD4+T cells from BC patients show enrichment in T-cell signaling, processes involved in DNA replication, p53 pathways, oncogene-induced senescence, among others compared to their counterparts in HDs. (institut-curie.org)
Correspondingly, most cancer signaling pathways seem to converge on one or more TFs, termed "master regulators" (MRs) [ 4 ], which direct tumor development, progression, and metastasis through hierarchical control of gene expression patterns. (aging-us.com)

Role of CtBP transcriptional repressors in cancer cell proliferation and survival In common with p53, CtBP1 and CtBP2 proteins were discovered through their physical association with a viral oncoprotein. (southampton.ac.uk)
Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. (thermofisher.com)
The objective of this study was to identify transcriptional regulatory proteins that mediate EBNA- 1 expression via the viral promoter Qp, which is active in EBV-associated tumors such as Burkitt lymphoma and nasopharyngeal carcinoma. (psu.edu)
Two tumor suppressor proteins p53 and p16 are responsible for cellular senescence 4 . (ijpsr.com)
There are two types of tumor suppressor proteins- the caretakers and the gatekeepers. (ijpsr.com)
We have shown that E1 and E2 proteins of human papillomavirus type 11 (HPV-11) were essential to support the replication of the homologous viral origin (ori) in a transient replication assay, similar to reports on bovine papillomavirus type 1 (BPV-1). (elsevierpure.com)
Either set of viral proteins was also able to initiate replication of ori-containing plasmids from many other human and animal papillomaviruses. (elsevierpure.com)
The control of nuclear localization via phosphorylation and dephosphorylation serves as the primary regulatory mechanism for MiT family proteins, and several kinases and phosphatases have been identified to directly determine the transcriptional activities of MiT proteins. (molcells.org)

Based on the heterogeneity within a specific tumor type, a combination of genomic alterations defines the cancer subtype, biologic behavior, and in some cases, response to therapeutics. (hindawi.com)
With increasingly high therapeutic efficacy being achieved recent years and owing to the unique features such as specific tumor tropism, low cytotoxicity against normal cells, OVT has been inviting a great attention as an ideal weapon against cancers. (biomedcentral.com)

Hypoxia and genetic defects that chronically drive proliferation leave such tumors dependent on a steady supply of nutrients, especially glucose. (springer.com)
This study aimed to explore adipogenic transcriptional dynamics before (proliferation) and after (differentiation) initial preadipocyte differentiation in ducks. (biomedcentral.com)

The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. (abnova.com)
The role of two members of the ETS (E26 avian leukemia oncogene) family of transcription factors, ETS-1 and ETS-2, has been investigated in many cancers but has not yet been studied in ocular tumors. (molvis.org)
The outcome was the identification of a transcription factor, TEA domain family member 4 (TEAD4), which controls cell cycle and DNA replication as the core control unit of the tumor checkpoint 3 . (cancerhealth.com)
Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins. (gorgoulis.gr)
These transcriptional factors belong to the basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. (molcells.org)

CDC6 acts as a prototypical oncogenic stimulus operating in a bimodal manner (1-4): i) triggering replication stress, fueling genomic instability (1,2,3), ii) functioning as a transcriptional repressor by switching off the INK4A/ARF and CDH1 ( E-cadherin ) loci, disrupting cell cycle progression and cell-to-cell communication (3,4). (gorgoulis.gr)
Recently, recurrent genomic rearrangements in intron 1 of TP53 have been described in osteosarcoma (OS), a highly malignant neoplasm of bone belonging to the spectrum of LFS tumors. (oncotarget.com)
DNA replication stress results from uncoupling of the replicative helicase and polymerase and is a key mechanism of genomic instability. (unmc.edu)
Furthermore, Cyclin E1 cooperated with FOXM1 to increase its transcriptional activity, which promoted cell cycle progression and genomic instability. (unmc.edu)
In agreement, TCGA HGSC tumors with both FOXM1 and CCNE1 copy number gain show increased FOXM1 and CCNE1 expression and genomic instability. (unmc.edu)

Currently, use of cannabinoids is limited to improve adverse effects of chemotherapy and their palliative administration during treatment is curiously concomitant with improved prognosis and regressed progression in patients with different tumor types. (frontiersin.org)

The p53 tumour suppressor protein is a key component of one such stress-response pathway, and virtually all cancers loose functionality of the p53-stress response pathway. (southampton.ac.uk)
We have a long-standing interest in the p53 protein, a stress-activated transcriptional activator. (southampton.ac.uk)
The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. (abnova.com)
0.1% O2) is one of the few physiologically relevant stresses that activates both the replication stress/DNA damage response and the unfolded protein response. (ox.ac.uk)
Replication of the Epstein-Barr virus (EBV) genome within latently infected cells is dependent on the EBV EBNA-1 protein. (psu.edu)

Further investigation indicated that the transcriptional activator IRF-1 and the closely related IRF-2, a repressor of interferon-induced gene expression, are both capable of activating Qp. (psu.edu)

These are used as primers in viral replication and ensure that the ends of the virus' linear genome are adequately replicated. (wikipedia.org)

In the p53 pathway, the gene activates its transcriptional target p21 which is an inhibitor of cyclin / cdk2 as they work for the progression of replication and inactivates RB. (ijpsr.com)

We show that, in the absence of p53, mdm2 confers a growth advantage to cells (i.e. "transforms" them) and can overcome a G1 cell-cycl arrest induced by p107, a member of the pRb tumour-suppressor family (Adams and Kaelin, 1995). (hal.science)

The directed expression of SV40 T antigen has led to the development of several important transgenic models with spontaneous epithelial tumor formation. (molvis.org)
Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune system's T-cells to recognize and attack tumor cells. (bvsalud.org)
Bi-specific chimeric antigen receptors may contribute to mitigating tumor antigen escape, but their efficacy could be limited in cases where certain tumor cells do not express the targeted antigens. (bvsalud.org)
Thus the interactions among the cis elements and trans factors of papillomaviruses are more conserved than expected from the other members of the papovavirus family, simian virus 40 and polyomavirus, for which large tumor antigen does not replicate a heterologous ori in either permissive or nonpermissive cells. (elsevierpure.com)

Although this is significantly larger than other viruses in its Baltimore group, it is still a very simple virus and is heavily reliant on the host cell for survival and replication. (wikipedia.org)
TEAD4 was shown as a prognostic marker of poor survival, with activity independent of the established Hippo pathway (regulates organ size) transcriptional co-activators, YAP and TAZ. (cancerhealth.com)
Survival status over time, as well as tumor volume (measured every 3 days) were monitored in both models. (bmj.com)

Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional control over hCdt1. (gorgoulis.gr)

This upregulation was correlated with tumor progression. (molvis.org)

In some circumstances, the activation of a stress-response pathway will actually help the tumour cell to survive and proliferate. (southampton.ac.uk)

citation needed] Adenoviruses possess a linear dsDNA genome and are able to replicate in the nucleus of vertebrate cells using the host's replication machinery. (wikipedia.org)
It is suggested that curcumin can selectively kill tumor cells through its multifaceted metabolic effects, that culminate in its anti-oxidant and anti-inflammatory activities ( Hewlings and Kalman, 2017 ). (frontiersin.org)
2015), that described how we intended to replicate selected experiments from the paper 'Transcriptional amplification in tumor cells with elevated c-Myc' (Lin et al. (elifesciences.org)
Effective immunotherapy of stromal-rich tumors requires simultaneous targeting of cancer cells and immunosuppressive elements of the microenvironment. (aacrjournals.org)
With the understanding particularly in the characteristics of viruses and tumor cells, numerous innovative OVs have been engineered to conquer cancers, such as Talimogene Laherparepvec (T-VEC) and tasadenoturev (DNX-2401). (biomedcentral.com)
OVT has its unique advantages and prospects, because oncolytic viruses (OVs) preferentially infect and replicate in tumor cells and destroy them, while leaving healthy cells largely untouched [ 7 ]. (biomedcentral.com)
Meanwhile, these non-engineered viruses sometimes inevitably infect and spread to normal tissues, indiscriminately killed both tumor and normal cells, causing a series of unpredicted side effects. (biomedcentral.com)
By the genetic recombination the viruses were conferred with high specificity against tumor cells without targeting normal tissues. (biomedcentral.com)
Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. (bvsalud.org)
T-cells are isolated from patients and modified to target tumor-associated antigens. (bvsalud.org)
To overcome these challenges, current research aims to identify reliable tumor-associated antigens and develop cost-effective, tumor microenvironment-specific CAR-T cells. (bvsalud.org)
5) increasing the intrinsic radioresistance of normal cells through ketone bodies but decreasing that of tumor cells by targeting glycolysis. (springer.com)
Cancer research has been conducted using cultured cells as part of drug discovery testing, but conventional two-dimensional culture methods are unable to reflect the complex tumor microenvironment. (medsci.org)
These T cells infiltrate tumors and tumor-draining lymph nodes. (institut-curie.org)
Transcriptional profiling of senescent CD4+T cells from the peripheral blood of BC patients reveals enrichment in genes associated with NK or CD8+-mediated cytotoxicity, TCR-mediated stimulation, and cell exhaustion compared to non-senescent T cells. (institut-curie.org)
Comparison of the transcriptional profile of senescent CD4+T cells from peripheral blood of BC patients with those of HDs highlighted marked similarities but also relevant differences. (institut-curie.org)
Our HCC signature covered well-established liver cancer hallmarks, and network analyses revealed coordinated interaction between several MRs. One novel MR, SEC14L2 , exerted an anti-proliferative effect in HCC cells and strongly suppressed tumor growth in a mouse model. (aging-us.com)

Ubiquitin-specific peptidases (USPs) regulate several critical cellular processes, such as cell cycle progression, transcriptional activation, and signal transduction. (bvsalud.org)

Brg1 is also involved in cell growth arrest, senescence and tumour supression. (thermofisher.com)
Cell senescence can be a result of the exposure to stress such as oxidative stress, epigenomic damage or DNA damage, or it can be due to telomere shortening is also known as end replication problem. (ijpsr.com)

Rather, transcriptional control of viral gene expression must play a dominant role. (elsevierpure.com)
TARGET investigators had previously identified distinct subtypes in high-risk neuroblastomas using transcriptome profiles and gene mutations (including amplifications), however, it was unknown to what extent changes in gene expression levels affected tumor development. (cancerhealth.com)
Over the last two decades, studies based on genome-wide gene expression and functional profiling have revealed the great diversity of transcriptional alterations occurring in liver carcinogenesis. (aging-us.com)

These data highlight a novel mechanistic insight into the hypoxia-induced transcriptional stress response through the ROS-R-loop-H3K9me2 axis. (ox.ac.uk)

Medulloblastoma, the most common malignant pediatric brain tumor , is a diverse and heterogenous disease with four major subgroups. (childrenscolorado.org)
In this pre-clinical study led by Rajeev Vibhakar, MD , investigators from multiple departments at Children's Hospital Colorado, including the Morgan Adams Foundation Pediatric Brain Tumor Research Program and the Neuro-Oncology Program for Children with Central Nervous System Tumors , sought to determine the effects of onvansertib on MYC-driven medulloblastoma as a monotherapy or in combination with radiation. (childrenscolorado.org)
Recently, the CTD 2 Center at Columbia University analyzed molecular characterization data from neuroblastoma (NBL) patient tumors, including the TARGET pediatric initiative, using predictive markers of risk for the development of precision oncology treatments for children. (cancerhealth.com)

We show that hypoxia-induced R-loops play a critical role in the transcriptional stress response, evidenced by the repression of ribosomal RNA synthesis and the translocation of nucleolin from the nucleolus into the nucleoplasm. (ox.ac.uk)

On day 19, Tumor Infiltrating Lymphocytes (TILS) were isolated by Ficoll gradient and submitted for immuno-phenotyping by CyTOF analysis to the HMRI ImmunoMonitoring Core, in addition, tumor lysates were used to measure cytokine expression using Millipore Sigma's Milliplex MAP Mouse Cytokine/Chemokine Magnetic Beads panel (cat: MCYTMAG-70K). (bmj.com)

Choroidal melanoma is the most common primary malignant ocular tumor in human adults. (molvis.org)

Combined, our results indicate promising potential of the real estate agents as book chemical substance tumor and probes therapeutics. (antiviralbiologic.com)

This offers significant advantages for studying tumor pathogenesis and molecular mechanisms of oncogenesis caused by a single initiating oncogenic event introduced through the mouse germ line. (molvis.org)
Aggressive tumors typically demonstrate a high glycolytic rate, which results in resistance to radiation therapy and cancer progression via several molecular and physiologic mechanisms. (springer.com)

Consideration of tumor heterogeneity is therefore important in the critical analysis of gene associations in cancer. (hindawi.com)
Unlike cancer arising in the human population, tumors in genetically engineered mouse models arise in mice with well defined genetic backgrounds where genetic variability can be minimized. (molvis.org)
The CTD 2 Network develops new approaches to identify genetic alterations that potentially influence tumor biology and characterize the role of these alterations in cancer development. (cancerhealth.com)
Spheroids made from oral cancer cell lines appeared to have tumor-like characteristics that may reflect their clinical significance. (medsci.org)
In the future, it may become possible to produce tumor spheroids from tissue samples of oral cancer patients, and then apply them to drug screening and to develop individualized diagnostic and treatment methods. (medsci.org)

Recent studies demonstrated that piperine potentiates curcumin's inhibitory effect on tumor progression via enhancing its delivery and therapeutic activity. (frontiersin.org)
We review the possible roles for calorie restriction (CR) and very low carbohydrate ketogenic diets (KDs) in modulating the five R's of radiotherapy to improve the therapeutic window between tumor control and normal tissue complication probability. (springer.com)

Investigators used CRISPR-Cas9 screening to determine which genes were essential for medulloblastoma tumor growth. (childrenscolorado.org)
Cell cycle and DNA replication are top signaling hubs for medulloblastoma cell growth. (childrenscolorado.org)
Therefore, it is difficult to propose that 2D culture accurately reflects the original growth state of tumor tissue. (medsci.org)
Results Triple combination inhibited tumor growth in the 4T1 model while significantly delaying E0771 tumor progression. (bmj.com)

Identification of such mutations provides targets for overcoming tumor resistance. (biomedcentral.com)

During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. (abnova.com)

The disease progresses through heterogeneous genetic alterations, and patients often develop pulmonary metastases even after the primary tumors have been surgically removed. (bvsalud.org)

Overall, this study highlights the contribution of transcriptional stress to hypoxia-mediated tumorigenesis. (ox.ac.uk)
This study advances our knowledge of transcriptional MRs potentially involved in HCC development and progression that may be targeted by specific interventions. (aging-us.com)

We infer that the stringent species and tissue specificities observed for papillomaviruses in vivo are not entirely due to direct restrictions on viral DNA replication. (elsevierpure.com)
However, the cellular environment under 2D culture is very different and often a poor reflection of the complex tumor microenvironment (TME) in vivo [ 1 ]. (medsci.org)

OVs, which are advancing into clinical trials, are being envisioned as the frontier clinical anti-tumor agents coming soon. (biomedcentral.com)

Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops. (ox.ac.uk)
induction of DNA replication stress could explain this association. (unmc.edu)

H-E staining showed tumor tissue-like structures specific to each cell line. (medsci.org)

The RUNX1: root injury strongly facilitates extent of the transcriptional value, forming process reaction cleavage 1( CD35)( Kim et al. (erik-mill.de)

We then used reverse engineering of transcriptional networks to identify the MRs that underpin the development and progression of HCC. (aging-us.com)

We hypothesized that the induction of cell death (Docetaxel) coupled with an immuno-activated milieu (locally injected adv.IL-12) would prime the tumor to respond to Anti-PD1 therapy. (bmj.com)

Anatomy17

Organisms20

Diseases49

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Phenomena and Processes70

Disciplines and Occupations1

Information Science3

Health Care5

Solid tumors4

Post-transcriptional2

Repressing tumor growth1

Apoptosis4

Regulation3

Inhibition4

Phenotype5

Assays2

Pathways6

Proteins8

Specific tumor2

Proliferation2

Transcription5

Genomic5

Progression in patients1

Protein5

Repressor1

Viral replication1

Activates1

Suppressor1

Antigen4

Survival3

Regulators1

Upregulation1

Pathway1

Cells17

Cellular processes1

Senescence2

Gene expression3

Mechanistic1

Pediatric3

Repression1

Cytokine1

Malignant1

Therapeutics1

Molecular2

Cancer5

Therapeutic2

Growth4

Resistance1

Heterochromatin1

Alterations1

Study2

Vivo2

Clinical1

Stress2

Tissue1

Strongly1

Development1

Induction1