Tumor regression tumor escape. Medical search. Frequent questions

While GB tumors are frequently infiltrated by natural killer (NK) cells, these are actively suppressed by the GB cells and the GB tumor microenvironment. (frontiersin.org)
Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)
In this study, we aimed to determine the heterogeneity of CSCs and its effect on the formation of tumor microenvironment (TME). (bvsalud.org)
The tumor microenvironment is complicated and continuously evolving. (bvsalud.org)
This study was devoted to the identification of potential prognostic biomarkers based on the tumor microenvironment associated with immunotherapy for melanoma. (bvsalud.org)
The second hypothesis, termed true CUP or genuine CUP, is that the primary lesion undergoes early regression while the metastases evolve independently, under the selection pressure of the immune system and their microenvironment. (medscape.com)
by contributing to sustained chronic inflammation as a result of modulating the immune cells so that the tumor microenvironment is activated by invasion of immune suppressive regulatory T cells, and/or by mediating the release of inflammatory mediators by immune cells with no anti-tumor activity. (jscimedcentral.com)
The interplay between the gliomas, the tumor microenvironment and infiltrating immune cells can hold key information to how to utilize PD-L1/PD-1 directed immunotherapies to successfully treat GBM patients. (jscimedcentral.com)
This divergent effect might be dependent on the glioma subclass, expression levels of PD-L1 and PD-L1 regulatory molecules, but most importantly on the cell type that express PD-L1 in the tumor microenvironment. (jscimedcentral.com)
Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells. (jscimedcentral.com)
Previously we found that mitotic factors regulate epithelial-mesenchymal transition, but how these factors convert to metastatic players in the tumor microenvironment (TME) is not fully understood. (biomedcentral.com)
This enhanced secretion of cholesterol and cholesteryl esters that impair CD8+ T cell function in the tumor microenvironment. (bvsalud.org)
The Workshop associated with the 27th Annual Meeting of the Society for Immunotherapy of Cancer (SITC), North Bethesda, MD, October 24-25, 2012 focused on targeting the tumor microenvironment as part of an integrative approach to immune-based cancer therapy. (biomedcentral.com)
The importance of these dynamic cellular interactions in the development of cancer has stimulated strong interest in evaluating components of the tumor microenvironment as targets for cancer therapy. (biomedcentral.com)
Multiple lines of research aim to dissect the tumor microenvironment to gain insight into cancer prognosis and treatment selection, as well as to further understand the mechanisms that drive immune-based tumor rejection. (biomedcentral.com)
To support these efforts, the Society for Immunotherapy of Cancer (SITC) held a workshop focused on targeting the tumor microenvironment as part of an integrative approach to immune-based cancer therapy. (biomedcentral.com)
These changes in the tumor microenvironment may lead to tumor cell death and eventually to a long-term memory immune response against tumor antigens. (drugdiscoverynews.com)
There is an extensive body of evidence that demonstrates that modulating the tumor microenvironment is critical to a successful outcome in cancer immunotherapy," added Dr. Sudhir Agrawal, president of Research at Idera. (drugdiscoverynews.com)
However, the molecular characteristics of tumor immune microenvironment (TIME) still need to be explored in depth. (biomedcentral.com)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
Immune cell infiltration occurs in the tumor microenvironment (TME) and influences cancer progression through interaction with tumor cells. (bjbms.org)
This finding implied the possible key role of RUNX1 in the differentiation of IDH mutant subtypes as well as in the formation of tumor microenvironment (TME) infiltration signatures by monitoring IFNGR2. (bjbms.org)

NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
Researchers have developed a virus-based vaccine expressing a broad spectrum of undefined antigens from normal human prostate tissue that they claim completely eradicates established mouse prostate tumors in experimental animals. (genengnews.com)
Moreover, any tumor cells that do manage to evade the initial antitumor immune response are mopped up after a second-line virus-based immunotherapy comprising a different set of antigens. (genengnews.com)
Effective cancer immuno- and virotherapies are hindered by a lack of identified tumor-associated antigens (TAAs), poor coverage of the antigenic repertoire expressed by tumors, and difficulties associated with targeting vectors to tumors in vivo , explains Dr. Vile, together with co-lead author Alan Melcher, at the U.K. Leeds Institute of Molecular Medicine and Cancer Research U.K. Clinical Center, and colleagues. (genengnews.com)
The team's previous work had already shown that killing normal cells in situ using the adjuvant hsp70 generated T cell responses to antigens that mediated rejection of tumors of the same histological type. (genengnews.com)
Nevertheless, building on the positive aspects of this approach, the researchers postulated that it may be possible to provide a broad antigenic repertoire for in vivo immune selection of relevant tumor-associated antigens by expressing a cDNA library of a normal tissue using a systemically delivered, immunogenic vector. (genengnews.com)
In addition, recurrent tumors expressed genes associated with an epithelial-to-mesenchymal-type transition, and had lost, or at least reduced, expression of mouse homologs of the human RNAs encoding prostate-specific antigens in the ASEL. (genengnews.com)
The development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor antigens, which should be tumor-specific as well as able to elicit a swift and potent anti-tumor immune response. (biomedcentral.com)
The vast majority of such strategies are based on tumor associated antigens (TAAs) which are shared wild type cellular self-epitopes highly expressed on tumor cells. (biomedcentral.com)
Tumor antigens can be classified into tumor-specific antigens (TSAs) and tumor-associated antigens (TAAs). (biomedcentral.com)
On the contrary, TAAs are wild-type self-antigens highly expressed on tumor cells compared to corresponding normal cells. (biomedcentral.com)
Indeed, the term "molecular mimicry" was originally introduced in 1964 to define the similarity between antigens expressed by infectious agents and human cells, as cause of the microbial escape from the host immune response and a more aggressive infection [ 14 ]. (biomedcentral.com)
One is the ability to administer large numbers of highly selected cells with high avidity for tumor antigens that can recognize shared and patient-specific mutated (neo) antigens. (biomedcentral.com)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
However, high-avidity T cells specific for tumor-associated antigens (TAAs) are usually absent in patients because of self-tolerance. (unimedizin-mainz.de)

Additionally, GPC2 is expressed in other pediatric embryonal malignancies including medulloblastoma and retinoblastoma, suggesting that GPC2 may be an immunotherapy target in other tumor types. (aacrjournals.org)
Collectively, these findings suggest that GPC2 may be an optimal target for immunotherapy in high-risk neuroblastoma and other embryonal tumors, supporting further development of GPC2-directed immunotherapeutics. (aacrjournals.org)
To aid in this effort, SITC provides a venue to facilitate the discussion of current clinical trial results and methodologies, as well as means to collaborate on new initiatives in tumor immunology and cancer immunotherapy with the ultimate goal of improving cancer patient outcomes. (biomedcentral.com)
However, not all patients respond to immunotherapy, acquired resistance remains a challenge, and responses are poor in certain tumors which are considered to be immunologically cold. (biomedcentral.com)
Inhibitors of the PD-1/PD-L1 immune checkpoint are one of the hot topics in tumor immunotherapy. (jcancer.org)
Therefore the application of immunotherapy has driven the treatment of brain tumors to the study of the response of intratumoral and systemic immune cells and cytokines to these malignancies 10 - 12 . (researchsquare.com)
Fortunately, with the advancement in knowledge of biology and comprehensive treatment of CCRCC, tumor immunotherapy has gradually become a promising alternative treatment approach for some urinary tract tumors due to its high accuracy and safety [ 6 , 7 , 8 ]. (biomedcentral.com)
Immunotherapy based on the adoptive transfer of ex vivo expanded and activated autologous tumor-reactive lymphocytes can mediate tumor regression in cancer patients. (unimedizin-mainz.de)

In addition, CSCs underwent self-renewal and tumor metastasis activity through WNT and ncWNT signaling. (bvsalud.org)
[ 4 ] One is that a single cell escapes the controls of normal cell replication, forms a tumor at the site of origin, and the tumor cells ultimately metastasize to other organs, but the original tumor is too small to be detected at the time of metastasis. (medscape.com)
FoxM1-based therapy would be a potential therapeutic strategy for LUAD to reduce TAM polarization, immune escape, and metastasis, since FoxM1 functions as a genetic reprogramming factor reinforcing LUAD malignancy in the TME. (biomedcentral.com)
Metastatic disease, also known as metastasis or metastatic cancer, refers to the spread of cancer from the original site (primary tumor) to other parts of the body. (transcodetherapeutics.com)
Over 90% of deaths from cancer are, in fact, due to metastasis and not the primary tumor. (transcodetherapeutics.com)
This elaborate web of diverse cell types fosters malignant tumor cell interactions with the tumor associated vasculature and fibroblasts as well as a variety of immune cells in support of tumor growth, invasion, and metastasis. (biomedcentral.com)
The host antitumor immune response can sculpt tumor growth, invasion, and metastasis in a variety of ways. (biomedcentral.com)
While tumor imaging and radiotherapy strategies are crucial for tumor identification and treatment, the presence of metastasis and radiation resistance has reduced the efficacy of treatment in cancer patients. (biomedcentral.com)
High stromal expression of PD-L2 predicted favorable overall and disease-free survival of NPC patients and was negatively correlated with tumor size, recurrence or metastasis and clinical stage. (jcancer.org)
However, they have a limited effect on patients with locally advanced or distantly metastatic disease, and approximately 30% of high-risk patients still experience tumor recurrence, with distant metastasis as the primary failure pattern [ 4 ]. (jcancer.org)

Targeting METTL3 by single-guide RNA, nanoparticle small interfering RNA (siRNA), or pharmacological inhibitor (STM2457) in combination with anti-programmed cell death protein 1 (PD-1) synergized to reinvigorate cytotoxic CD8+ T cells and mediate tumor regression. (bvsalud.org)
Tumor-specific neoantigens, which are expressed on tumor cells, can induce an effective antitumor cytotoxic T-cell response and mediate tumor regression. (wjgnet.com)

In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
Intracranial Germ Cell Tumors (iGCTs) are rare brain tumors that originate from embryonic germ cells. (researchsquare.com)

If successful, this proposal will provide the necessary data that will enable the design of clinical trials for improved delivery of tumor killing viruses for the treatment of nonresectable, recurrent, or metastatic solid tumors using stem cell-derived biocarriers. (ca.gov)
Although immune checkpoint inhibitors have opened a new mode of treatment for solid tumors, their efficacy in nasopharyngeal carcinoma (NPC) needs to be further investigated. (jcancer.org)

This expression was dependent on activation of either NF-κB, JAK1/JAK2 or BTK pathways since these pathways were activated in tumor B-cells and ex vivo treatment with the inhibitory molecules PHA-408, ruxolitinib and ibrutinib led to decrease of its expression. (springer.com)
The study and/or manipulation of administered cells can potentially result in identification of the exact cell subpopulations and effector functions required for cancer regression in vivo. (biomedcentral.com)

In particular, using the tetracycline regulatory system, we have generated a conditional model system for MYC-induce hematopoietic tumors. (stanford.edu)
Thus, even though cancer is a multi-step process, the inactivation of one oncogene can be sufficient to induce tumor regression. (stanford.edu)
Reporting in Nature Medicine , the team in the U.S. and U.K. that developed the approach says the vaccine can be delivered systemically without the need for tumor targeting, appears to have no side effects, and doesn't induce autoimmunity. (genengnews.com)
Oncolytic viruses (OVs) specifically induce cancer cells death by infection of and spreading on tumor cells through different mechanisms such as direct lysis effect or adjacent cells fusion. (biomedcentral.com)
For recent decades, it has been recognized that malignant tumor cells potentially induce local and systemic immunosuppression 9 . (researchsquare.com)

Escape from immune surveillance is thought to contribute to the development and progression of GB. (frontiersin.org)
The pathway is involved in both tumor development and progression. (harvard.edu)
Background:Serum cathepsin B activity has been considered a potential marker of tumor progression. (medscimonit.com)
The aim of this study was to assess serum cathepsin activity during tumor progression and regression.Material/Methods: Of 60 female rats inoculated with Morris hepatoma cells, 45 were treated with BRT, and the remaining 15 were left without treatment. (medscimonit.com)
In all non-treated rats, tumor progression was observed. (medscimonit.com)
The demonstration of ET-1 as an important mediator in the progression of many tumors clearly identifies the ET axis as a potential therapeutic target. (biomedcentral.com)
However, up to now, no existing study has reported whether GNG7 affects the occurrence and progression of tumor diseases by participating in the immune system. (biomedcentral.com)
Immune system dysfunction is significantly correlated with tumor initiation and progression. (aging-us.com)

Moreover, the efficacy of such a highly personalized approach is possibly reduced by the high mutational rate of tumors, which drives a constant generation of new target mutated neoantigens and a consequent cancer immune evasion. (biomedcentral.com)

1. by inhibiting cytotoxic T-lymphocytes from destroying the tumor cells, 2. (jscimedcentral.com)
In a subset of 21 patients, pretreatment tumor tissue was analyzed for activation, differentiation and spatial distribution of tumor infiltrating lymphocytes (TIL). (merkelcell.org)

Prostate cancer is the most common malignant tumor in male adults in the Western world, which represents a major cause of cancer-related morbidity and mortality. (compassionateacupuncture.com)

The pre-clinical LMP1/CD40-expressing transgenic mouse model is characterized by B-cell specific CD40 signaling responsible for NF-κB continuous activation with a spleen monoclonal B-cell tumor after 1 year in 60% of cases. (springer.com)
In clinical practice, a key challenge for generating TIL products is the accessibility, quantity, and quality of tumor tissue in the era of neo-adjuvant therapy. (biomedcentral.com)
IDO is one of several immune checkpoints involved in tumor immune escape, and IDO-1 inhibitors are currently in clinical development, according to the company. (drugdiscoverynews.com)
Among tumor immunotherapies, neoantigen vaccines are in early human clinical trials and have demonstrated substantial efficiency. (wjgnet.com)
In their review " Natural and Adaptive Immunity to Cancer ", Vesely and colleagues draw from recent mouse models of cancer and human clinical data to describe how cells, effector molecules, and pathways of the immune system act to suppress and control tumor cells. (massgenomics.org)
Canine Transmissible Venereal Tumour (TVT) is reviewed, based on clinical data of more than 500 cases recorded in our Clinic during the last 25 years, with special reference to its treatment with vincristine. (vin.com)
However, the clinical application of tumor-infiltrating γδ T cells has certain limitations. (explorationpub.com)

Three intravenous ASEL injections typically induced initial tumor regression, but with subsequent aggressive tumor recurrence. (genengnews.com)
To address the problem of tumor recurrence, the researchers evaluated combinations of vaccination with differ-ent libraries. (genengnews.com)

The phenomena of immune escape and the auto-immunity elicited by the molecular mimicry may appear as contradictory but are the two faces of the same coin, representing the extremes of a biological continuum. (biomedcentral.com)
The immune system can generate anti-tumor immunity by affecting tumor growth and mutation behaviors. (biomedcentral.com)

In some cancers, PD-L1 expression by tumor cells correlates with a good prognosis for the patient, whereas in glioblastoma many reports suggest that it is a bad prognostic marker. (jscimedcentral.com)
These results demonstrate that the early tumor response to this regimen is T and NK cell independent, but that NK cells have a role in generating lasting cures in the absence of MHC-I expression by tumor cells. (bmj.com)

How does oncogene inactivation cause tumor regression? (stanford.edu)
Many cancers, including pancreatic ductal adenocarcinoma (PDAC), depend on autophagy-mediated scavenging and recycling of intracellular macromolecules, suggesting that autophagy blockade should cause tumor starvation and regression. (cornell.edu)

While this approach led to a broad repertoire of individually weak T cell responses against multiple TAAs that cumulatively resulted in strong selective pressure against immune escape, the need to inject the vectors into normal tissues often results in toxicity, they admit. (genengnews.com)

Further, the antibody-drug conjugate promoted durable tumor regression in a patient-derived xenograft (PDX) model of MYCN -amplified neuroblastoma, extending survival with minimal toxicity. (aacrjournals.org)
Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy. (trafalgar.com.hk)
Inhibition of LIN28B also caused the regression of established xenograft human tumors in mice. (puromond.me)

This phenomenon could be offset by a dual-CAR system incorporating both an activating CAR against the cognate tumor antigen and an NK self-recognizing inhibitory CAR that transferred a 'don't kill me' signal to NK cells upon engagement with their TROG + siblings. (nature.com)
Fig. 1: CAR19-mediated trogocytosis in NK cells cocultured with CD19 + tumor targets. (nature.com)
The dependency of neuroblastoma cells on GPC2 expression may prevent the emergence of immune escape mechanisms in response to therapeutic targeting. (aacrjournals.org)
Now, a research team led by investigators at Harvard Medical School and Beth Israel Deaconess Medical Center has found a way to attack a process that tumor cells use to escape the effects of standard cancer drugs. (harvard.edu)
Our work has uncovered a vulnerability in human breast cancer that is used by tumor cells to escape the lethal effects of conventional chemotherapy and that leads to resistance to such therapies," explained Toker, chief of the Division of Signal Transduction at Beth Israel Deaconess. (harvard.edu)
Moreover, because glutathione is only one of several antioxidants within cells, the researchers wonder whether there are other antioxidant pathways in tumor cells that are hijacked by the PI3K/AKT pathway to drive cancer. (harvard.edu)
Develop a stem cell-based platform that safely and efficiently delivers viruses that specifically kill tumor cells and restore immune activity in patients with advanced cancer. (ca.gov)
LMP1/CD40 tumors B-cells expressed high levels of PD-L1. (springer.com)
Treatment of LMP1/CD40-expressing lymphomatous mice with an anti-PD-L1 monoclonal antibody induced tumor regression with decreased spleen content, activation and proliferation rate of B-cells as well as a marked increase in T-cell activation, as assessed by CD62L and CD44 expression. (springer.com)
Given the heterogeneity and complex etiology of the GBM and the origin of the tumor cells, it is not surprising that the environment that surrounds the tumors display wide varieties of responses. (jscimedcentral.com)
Issazadeh-Navikas S. Alerting the immune system via stromal cells is central to the prevention of tumor growth. (jscimedcentral.com)
CIBERSORT and Tracking of Indels by DEcomposition (TIDE) analyses were adopted to assess the infiltration abundance of immune cells and tumour immune escape. (biomedcentral.com)
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. (cornell.edu)
We now show that autophagy blockade prompts established PDAC to upregulate and utilize an alternative nutrient procurement pathway: macropinocytosis (MP) that allows tumor cells to extract nutrients from extracellular sources and use them for energy generation. (cornell.edu)
It occurs when cancer cells break away from the primary tumor, travel through the bloodstream or lymphatic system, and establish new tumors in different organs or tissues. (transcodetherapeutics.com)
Once in the bloodstream or lymphatic system, cancer cells can travel to distant organs or tissues, where they can lodge and form secondary tumors. (transcodetherapeutics.com)
This radically novel and highly promising therapeutic strategy against cancer relies on specific eradication of metastatic tumor cells- cells that have acquired the ability to escape into the circulation, survive during transit, and colonize a distant vital organ, such as the lungs and brain. (transcodetherapeutics.com)
TSAs arise from cancer-related nonsynonymous mutations or other genetic alterations, which give rise to mutated peptides presented by HLA only on the cell surface of tumor cells (neoantigens). (biomedcentral.com)
Established tumors are complex, heterogeneous masses composed of malignant cells admixed with a variety of non-transformed host cells, including stromal cells, endothelial cells, and immune cells. (biomedcentral.com)
The prevention of immune cell access into the tumor, the accumulation of inhibitory FoxP3 + regulatory T cells (Treg) and/or myeloid-derived suppressor cells (MDSCs), the activation of negative immunoregulatory pathways, and the dysregulation of effector T cells are all mechanisms by which tumors evade the host immune system. (biomedcentral.com)
Compared with conventional cancer treatments, the main advantage of oncolytic virotherapy is its tumor-selective replication followed by the destruction of malignant cells without damaging healthy cells. (biomedcentral.com)
The ability of OVs to selectively infect tumor cells is mainly associated with the disruption of type-I interferon pathway, which represents the first line of defense against viral infections. (biomedcentral.com)
In this case, the stimulation of endoplasmic reticulum (ER) stress and subsequent immunogenic cell death (ICD) process in OVs-infected cells elicit a range of anti-tumor immune responses. (biomedcentral.com)
On the other hand, the proliferation of oncolytic viruses into target cells and subsequent recognition of viral elements by pattern recognition receptors (PRRs) such as toll-like receptors can positively affect the development of the innate and adaptive immune responses against tumor cells (Fig. 1 ) [ 6 ]. (biomedcentral.com)
Schematic illustration of the multimodality role of virotheranostics in treatment and tracking of tumor cells. (biomedcentral.com)
Successful TIL therapy starts with the identification, enrichment, stimulation, and expansion of potent tumor-reactive T cells. (biomedcentral.com)
Early suppression of 9464D-GD2 tumors by CAIR does not require T or natural killer (NK) cells, but eventual tumor cures are NK cell dependent. (bmj.com)
Conclusion Treatment with CAIR cures 9464D-GD2 tumors in a NK cell dependent manner and induction of MHC-I by tumors cells was associated with decreased efficacy. (bmj.com)
Further strategies to better inhibit tumor outgrowth in this setting may require further NK activation or the ability to engage alternative immune effector cells. (bmj.com)
Programmed cell death-1 (PD-1) is mainly expressed on activated T cells and acts as an immune activation reaction of tumors after the combination of inhibitory receptor and ligand (PD-L1). (jcancer.org)
The idea that the immune system might recognize and destroy tumor cells was conceived 50-100 years ago. (massgenomics.org)
Significant morphological differences have been repeatedly demonstrated to exist between normal dog cells and cells of the tumour. (vin.com)
Tumour cells are exfoliated and transplanted during coitus from animal to animal and perpetuate themselves like any other heterologous, mono-cellular organism. (vin.com)
Nomogram and multivariate Cox Regression analysis indicated increased Tc cells was related to reduced risk death(p = 0.001,HR = 0.217 95%CI = 0.085-0.551). (researchsquare.com)
These cells may be a key factor ultimately mediating the deviation of the antagonistic response between tumor inhibition and tumor promotion. (explorationpub.com)
According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)
It was found that absence of immunosuppression, a limited number of tumor-affected organs, and an elevated number of 'killer' (CD8 T) cells within the tumor were associated with a higher chance of responding to immune therapy. (merkelcell.org)
Multiplexed immunohistochemistry demonstrated the predominance of CD8 + effector and central memory T cells (T CM ) in close proximity to tumor cells in patients with a favorable therapy response. (merkelcell.org)
T cells and TCR will be obtained from blood and tumor tissue and tested for neoantigen specificity and tumor reactivity. (unimedizin-mainz.de)

Efficacy of immunotherapies against the PD-1/PD-L1 axis in lung tumors or melanomal demonstrated the importance of the immune checkpoints in the control of emergence and growth of tumors [ 2 ]. (springer.com)
Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors. (jscimedcentral.com)

In this study, we first used online related databases and related LGG data from TCGA and CGGA to conduct bioinformatics analysis, which confirmed that RUNXs were significantly and positively correlated with immune infiltration in multiple tumors, especially in low-grade glioma (LGG) and there was the highest correlation between RUNXs and the progress and prognosis of LGG. (bjbms.org)

Inhibition of MP in autophagy-compromised PDAC elicits dramatic metabolic decline and regression of transplanted and autochthonous tumors, suggesting the therapeutic promise of combining autophagy and MP inhibitors in the clinic. (cornell.edu)
However, we are also very excited to further understand what other areas we can apply the technology to, such as in tumors that may not be immunogenic and perhaps unresponsive to checkpoint inhibition. (drugdiscoverynews.com)

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. (jscimedcentral.com)
G to T transversion mutations in codon 249 of the p53 tumour-suppressor gene have been found in human liver tumour from geographic areas with high risk of aflatoxin exposure and in AFB 1 -induced liver toxicity [ 8 ]. (hindawi.com)
Constitutional PV's in the tumor suppressor gene adenomatous polyposis coli (APC) result in constitutive activation of the Wnt signaling pathway through deregulation of β-catenin, causing downstream effects on proliferation and differentiation within colonic crypts. (aacrjournals.org)

Histological observation confirmed the induction of tumour in Group II animals and complete regression of tumour in Group III animals. (hindawi.com)

Methods: We depicted the landscape of HNSCC transcriptome profile by single-cell RNA-sequencing analysis of 20 HNSCC tissues from public databases, to reveal the Cell components, trajectory changes, signaling network, malignancy status and functional enrichment of CSCs within tumors. (bvsalud.org)
Consequently, finding novel methods for increasing the efficiency of tumor imaging and treatment is of great importance [ 1 , 2 ]. (biomedcentral.com)
Methods Mice bearing GD2-expressing 9464D-GD2 tumors were treated with CAIR (external beam radiotherapy, hu14.18-IL2 immunocytokine, CpG, anti-CD40, and anti-CTLA4) and tumor growth and survival were tracked. (bmj.com)

Apparently, certain immune system pathways (e.g. inflammation) instead serve to promote tumor growth. (massgenomics.org)

We identified Eiger, the Drosophila tumor necrosis factor (TNF) homolog, as the signal responsible for apoptosis-induced apoptosis (AiA). (elifesciences.org)

Overcome the inherent limitations that prevent efficient intravenous delivery of tumor killing viruses to metastatic tumors. (ca.gov)

Gliomas promote immunosuppression through induction of B7-H1 expression in tumor-associated macrophages. (jscimedcentral.com)
This invasive form of p -FoxM1 upregulates the expression of IL1A/1B, VEGFA, and IL6 by direct activation, recruiting monocytes and promoting the polarization of M2d-like tumor-associated macrophages (TAMs). (biomedcentral.com)

Kingwell K. Neuro-oncology: Glioblastoma prognosis linked to neuronal PD-L1 expression in tumour-adjacent tissue. (jscimedcentral.com)
A total of 90.8% of the cases showed membranous PD-L2 expression in tumors, and 80.8% showed membranous PD-L2 expression in stromal tissue. (jcancer.org)

PD-L1 expression by neurons nearby tumors indicates better prognosis in glioblastoma patients. (jscimedcentral.com)
and (4) the tumor Immunoscore as a new indicator of prognosis, and predictive marker of response to cancer therapy. (biomedcentral.com)

For example, in patients whose tumors are found to have high microsatellite instability/deficient mismatch repair (MSI-H/dMMR), treatment with an immune checkpoint inhibitor (programmed cell death inhibitor) may significantly improve survival. (medscape.com)
IDO1 is the most studied and regulates immune cell function through the KYN pathway, and treatment combining immune checkpoint inhibitors (ICIs) with IDO1 blockade tends to inhibit tumour growth. (biomedcentral.com)
According to Doody, preclinical studies using IMO-2125 either as a single-agent or in combination with several checkpoint inhibitors-such as anti-CTLA-4, anti-PD-1 and IDO-1 inhibitor-have shown robust tumor regression. (drugdiscoverynews.com)

A Bayesian cumulative ordinal regression model revealed absence of immunosuppression and a limited number of tumor-involved organ systems was highly associated with a favorable therapy response. (merkelcell.org)
Conclusions Our findings indicate the absence of immunosuppression, a limited number of tumor-affected organs, and a predominance of CD8 + T CM among TIL, as baseline parameters associated with a favorable response to PD-1/PD-L1 ICI therapy of advanced MCC. (merkelcell.org)

Compare the relative efficacy of native or cargocyte-delivered oVSV∆M51-GFP to exit tumor blood vessels and escape neutralizing antibodies. (ca.gov)

A primary tumor can be found at autopsy in as many as 50-80% of CUP cases. (medscape.com)

Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and currently incurable. (frontiersin.org)
Glioblastoma (GB) is the most frequent malignant primary brain tumor in adults, without any curative treatment options available at present. (frontiersin.org)

The recurrent tumors demonstrated substantial histological differences from the parental tumors, and extensive interstitial lymphocyte infiltrates. (genengnews.com)
Serum cathepsin B activity was determined, tumor volumes were measured, and histological examinations of the tumor tissues were performed.Results: Of the 45 BRT-treated rats, tumor regression was observed in 31 rats, and serum cathepsin activity was analyzed in these rats. (medscimonit.com)

The putative targets were cell-surface proteins (or proteins with extracellular epitopes) highly expressed in neuroblastoma compared with normal tissues, and expressed in the majority of tumors. (aacrjournals.org)
GPC2 was highly expressed on the plasma membrane of the majority of neuroblastoma tumors, and its expression was limited in normal tissues, suggesting the possibility for therapeutic targeting with minimal toxicity. (aacrjournals.org)
The expression of PD-L2 exhibited different spatial patterns among NPC tumor and stromal tissues. (jcancer.org)

Therefore, it is not surprising that physically preventing effector CD8 + T cell infiltration or inhibiting their activity once they gain access to the tumor might be a means by which tumors protect themselves from immune attack, enabling them to persist within the host. (biomedcentral.com)

Results CAIR cures some mice bearing small (50 mm 3 ) but not larger (100 mm 3 ) 9464D-GD2 tumors and these cured mice develop weak memory responses against tumor rechallenge. (bmj.com)

Clear cell renal cell carcinoma (CCRCC) is a common tumor of the urological system for which surgery is the preferred treatment, but there is a lack of therapeutic options after surgery. (biomedcentral.com)
Army military vehicles offer some more detailed specifications on three such models: the model escape from tarkov wallhack free trial WC and WD models, and the inch wheelbase version of the SNL G-number aka the WF Cancer: stratifying tumours for treatment Genomic medicine has already shown benefit in refining diagnoses and guiding therapeutic approaches for cancer. (puromond.me)
Therapeutic response correlates with the mutational load of the patient tumors, suggesting that neoantigens contribute to tumor rejection. (unimedizin-mainz.de)

Single-cell RNA sequencing revealed that METTL3 suppressed antitumor immune response by reducing granzyme B (GZMB+) and interferon gamma-positive (IFN-Î³+) CD8+ T cell infiltration, thereby facilitating immune escape. (bvsalud.org)

This combination caused significant regression of breast cancer with PI3K/AKT pathway mutations, both in laboratory dishes and in mice. (harvard.edu)
Further research is also needed to determine if enhanced glutathione production is also observed in tumors that harbor mutations other than those in the PI3K/AKT pathway. (harvard.edu)

The morbidity associated with RTK is extremely rare, accounting for about 2% of renal tumors in children. (aging-us.com)

Liquid biopsy has overcome the many limitations of tumor biopsy, but its exact place in the spectrum of testing in cancer of unknown primary is still being studied. (medscape.com)
Studying these groups on regular cancer surveillance provides insight into the tumor biology, potential avenues for prevention, and their effectiveness. (aacrjournals.org)
Conclusions: Cathepsin B may play an important role, not only in tumor expansion, but also during the processes of cancer cell death and resorption. (medscimonit.com)
The discovery and development of novel treatments that harness the patient's immune system and prevent immune escape has dramatically improved outcomes for patients across cancer types. (biomedcentral.com)

Thus, clinically evident MCC occurs either in immuno-compromised patients or based on tumor-intrinsic immune escape mechanisms. (merkelcell.org)

Background: Malignant rhabdoid tumor of the kidney (RTK) is a rare and highly aggressive pediatric malignancy. (aging-us.com)
Malignant rhabdoid tumor of the kidney (RTK) is a rare and highly lethal malignancy that primarily affected infants and young children [ 1 ]. (aging-us.com)
We classified patients into groups on the basis of underlying diseases: immunocompetent patients, solid tumor patients, solid organ transplantation recipients, hematopoietic stem cell transplant recipients, hematologic malignancy patients, and patients receiving long-term steroid treatment. (cdc.gov)

Considering the strong evidence that TRP metabolism mediates tumour development and immune suppression, a comprehensive analysis of the TRP pathway might improve the development of survival biomarkers and provide potential strategies for the precise treatment of HCC patients. (biomedcentral.com)
In contrast, high tumor abundance of PD-L2 correlated with poor disease-free survival, but had no obvious correlation with clinicopathological parameters. (jcancer.org)
This study retrospectively analyzed serum lymphocyte subsets and survival outcomes in intracranial germ cell tumors (iGCTs) patients. (researchsquare.com)

This process results in heterogeneous and genetically diverse tumors that are aggressive and resistant to therapy. (medscape.com)

How do tumors escape dependence on oncogenes? (stanford.edu)

Immunotherapeutic GPC2 targeting may be beneficial in high-risk neuroblastoma and other embryonal tumors. (aacrjournals.org)
76 patients were confirmed germinoma, 29 mixed germ cell tumor, 4 teratoma, 9 malignant teratoma, 6 endodermal sinus tumor, 20 choriocarcinoma and 1 embryonal carcinoma. (researchsquare.com)
Classification of central nervous system germ cell tumors according to the World Health Organization divides them into germinoma and non-germinoma germ cell tumors(NGGCTs), with 6 different types of the latter, which includes teratoma, embryonal carcinoma, endodermal sinus tumor (yolk sac tumor), chorionic epithelioma (also called choriocarcinoma) and mixed germ cell tumors(GCTs) 7 (including above components sometimes teratoma and germinoma as well). (researchsquare.com)

We previously demonstrated that low-frequency electromagnetic stimulation (LF EMS), called bioresonance therapy (BRT), may both accelerate and inhibit the growth of transplantable hepatoma (Morris type 5123D), including total tumor regression. (medscimonit.com)

Regression analysis was used to profile independent prognostic factors. (bvsalud.org)
However, it is ambiguous for simple tumor makers to evaluate patients' changing conditions and to predict outcomes, not to mention the evaluation and prognostic significance of patients with negative tumor indicators. (researchsquare.com)

They first tried a second vaccination comprising virally expressed immune-escape epitope libraries (IEELs) constructed using cDNA from the recurrent tumors of ASEL-treated mice. (genengnews.com)

Anatomy18

Organisms10

Diseases74

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment64

Psychiatry and Psychology1

Phenomena and Processes43

Disciplines and Occupations1

Information Science4

Health Care20

Microenvironment24

Antigens15

Immunotherapy8

Metastasis10

Mediate2

Brain tumors2

Solid tumors2

Vivo2

Induce5

Progression8

Mutated neoantigens1

Lymphocytes2

Malignant tumor1

Clinical7

Recurrence2

Immunity2

Expression by tumor cells2

Cause tumor2

TAAs1

Xenograft3

Cells39

Lung tumors2

Multiple tumors1

Inhibition2

Suppressor3

Complete regression1

Methods3

Promote tumor1

Necrosis factor1

Metastatic1

Macrophages2

Tissue2

Prognosis2

Checkpoint3

Immunosuppression2

Efficacy1

Primary tumor1

Glioblastoma2

Histological2

Tissues3

Effector1

Responses1

Therapeutic3

Antitumor1

Mutations2

Renal1

Cancer4

Mechanisms1

Malignancy3

Survival3

Aggressive1

Oncogenes1

Embryonal3

Inhibit1

Prognostic2

Recurrent1