Tumor proliferation and apoptosis tumor cells cultured. Medical search. Frequent questions

We demonstrate that UCN-01, at concentrations lower than those necessary to inhibit cancer cell growth, inhibit proliferation of human endothelial cells in vitro. (karger.com)
To search for possible modes of action of retinoids as novel therapeutic options, primary tumor cell cultures were treated in vitro with all-trans-RA (ATRA), 9cis-RA, fenretinide and combinations of retinoids and a histone deacetylase (HDAC) inhibitor. (uni-wuerzburg.de)
In vitro testing of primary tumor cultures provided clear evidence of a potential utility of retinoids in Wilms tumor treatment based on the analysis of gene expression, proliferation, differentiation and apoptosis. (uni-wuerzburg.de)
Knockdown of PD-1 enhanced SW480 viability in-vitro, while overexpression of PD-1 diminished cell viability. (jcancer.org)
They hypothesized that IP6 would inhibit the cell growth rate of Barrett's adenocarcinoma in vitro. (naturalnews.com)
They hypothesized that IP6 would significantly inhibit cell growth of cutaneous melanoma in vitro. (naturalnews.com)
They hypothesized that IP6 would significantly inhibit cell growth and increase the apoptotic rate of pancreatic cancer in vitro. (naturalnews.com)
We report (1) the synthesis and validation of a fluorophore-conjugated, Sudan Black-B analog (GLF16), suitable for in vivo and in vitro analysis of senescence by fluorescence microscopy and flow cytometry and (2) the development and application of a GLF16-carrying micelle vector facilitating GLF16 uptake by living senescent cells in vivo and in vitro. (bvsalud.org)
In vitro 3D tissue-engineered (TE) structures have been shown to better represent in vivo tissue morphology and biochemical pathways than monolayer culture, and are less ethically questionable than animal models. (sdlifesciences.com)
This work demonstrates the first report of the simultaneous co-culture and differentiation of 3D TE skeletal muscle and bone, and represents a significant step toward a full in vitro 3D musculoskeletal junction model. (sdlifesciences.com)
Furthermore, POGLUT2 knockdown of breast cancer cells was established, followed by in vitro biological function assays and in vivo tumor growth study. (frontiersin.org)
In vitro and in vivo results showed that POGLUT2 knockdown could delay tumor growth and progression. (frontiersin.org)
Scholars@Duke publication: Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance. (duke.edu)
In vitro, the affinity and internalization kinetics of 111 In-R1507 were determined using the IGF-1R-expressing triple-negative breast cancer cell line SUM149. (snmjournals.org)
To address the challenges, we have developed multiple in vitro models to assess the biological and toxicological activities of well-characterized NPs with the identification of target lung cells of pulmonary exposed NPs from animal studies. (cdc.gov)
Based on established in vivo doses that induce significant pulmonary disorders, physiologically relevant in vitro doses (i.e., 0.02 - 0.2 microg/cm2) of NPs, including carbon nanotube s (CNTs) and iron oxide NPs (nFe2O3), were used to evaluate their toxic effects on human lung cells under long-term exposure condition (up to 6.5 months). (cdc.gov)
Our in vitro studies determined specific particle type- and cell type-dependent NP-induced cell proliferation, anchorage-independent growth, apoptosis evasion, and increased cell migration and invasion. (cdc.gov)
RFC4 knockdown induced G2/M cell cycle arrest and inhibited NPC cell proliferation in vitro and in vivo . (engineering.org.cn)
Infection of epithelial cells and lymphocytes has been shown to induce apoptosis in vitro ( 4 - 8 ). (cdc.gov)

This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca2+ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the incidence of interruption in antitumoral treatment. (researchgate.net)
Molecular features of these tumors have expanded our vision of tumorigenesis and progression and provided abundant specifically targeted pathways [ 5 ]. (hindawi.com)
As an important member of the miRNA family, miR-381-3p also mediates tumor progression. (hindawi.com)
PTEN can inhibit cell cycle progression and induce cell death to stimulate angiogenesis [ 6 ]. (aging-us.com)
Whether C. tropicalis participates in the progression of CRC and immunotherapy resistance through regulating the tumor cell-intrinsic PD-1 remains to be further elucidated. (jcancer.org)
This shows that C. tropicalis promotes CRC progression via controlling the expression of tumor cell-intrinsic PD-1. (jcancer.org)
C. tropicalis can down-regulate tumor cell-intrinsic PD-1 expression via enhancing tumor cells autophagy levels to promote CRC progression. (jcancer.org)
In Dr. A.M. Shamsuddin's review of findings in Nutrition and Cancer vol. 55, he states that in addition to its role in cancer prevention and control of experimental tumor growth, progression and metastasis, IP6 possesses other significant benefits, such as the ability to enhance the immune system, function as a natural antioxidant, prevent calcification and kidney stone formation, lower elevated serum cholesterol, and reduce pathological platelet activity. (naturalnews.com)
Though sunitinib inhibits the progression of basal-like breast cancer by directly targeting each tumor cells and vasculature the possibility ought to be deemed that it may enhance breast cancer stem cells. (cyp3a-cyp450.com)
The present study demonstrates that the treatment with single-agent sunitinib is very helpful in the inhibition from the basal-like breast cancer progression by straight targeting both of tumor cells and tumor vasculature working with MDA-MB-468 xeno. (cyp3a-cyp450.com)
The matched series of normal MCF-10A, pre-malignant MCF-10AT, and malignant MCF-10CA1a cells offers a unique opportunity to study the mechanisms of malignant progression both in a three-dimensional microenvironment and in the same cell background. (biomedcentral.com)
Increased levels of POGLUT2 could result in the dysregulated immune cell infiltration and tumor microenvironment and showed a significant regulatory effect on the progression of breast cancer through Notch-related signaling. (frontiersin.org)
Statins may inhibit tumor progression via an EZH2-mediated epigenetic alteration, which results in survival benefits after resected CRC. (nih.gov)
Midline2 (MID2) is an ubiquitin-conjugating E2 enzyme linked to tumor progression and a novel interacting partner of breast cancer 1, early-onset (BRCA1). (engineering.org.cn)

In conclusion, SCARA5 inhibited the proliferation and EMT and induced the apoptosis of OSCC cells through the inhibition of STAT3 and PI3K/AKT signaling pathways, thereby exerting a tumor suppressor effect. (degruyter.com)
PTEN gene is considered an established tumor suppressor gene in different types of cancer including breast cancer. (cancerindex.org)
This study shows that PD-1 is a tumor suppressor in CRC. (jcancer.org)
Drs. Kim Vanderlinden and Ivana Vucenik describe what is presently known about how IP6 works to help normalize the rate of cell division, normalize cell physiology, enhance Natural Killer (NK) cells, increase tumor suppressor P53 gene activity, inhibit inflammation, and inhibit angiogenesis. (naturalnews.com)

Our research proposed viable tumor cells with altered biological features by DMSO-treatment could induce anti-tumor immunity in vivo . (oncotarget.com)
Our preclinical studies demonstrate that Triphala is effective in inhibiting the growth of human pancreatic cancer cells in both cellular and in vivo model. (biomedcentral.com)
In three-dimensional reconstituted basement membrane culture, they undergo a well-defined program of proliferation, differentiation, and growth arrest, forming acinar structures that recapitulate many aspects of mammary architecture in vivo . (biomedcentral.com)
By live in vivo imaging, ovarian cancer xenograft tumors were reduced after primary treatment with carboplatin. (duke.edu)
In vivo, the pharmacodynamics of 111 In-R1507 and 125 I-R1507 were determined in mice with subcutaneous SUM149 tumors. (snmjournals.org)
Present study data showed that NPs were able to induce dose- and time-dependent cytotoxicity, inflammation, fibrogenesis and neoplastic transformation of human lung cells, consistent with in vivo data. (cdc.gov)
Furthermore, by developing a fibroblast stem cells (FSC)-enriched fibroblast focus model to mimic in vivo fibrogenic response, we demonstrated a dose-dependent increase in fibroblast focus formation and collagen production by primary lung fibroblasts treated with multi-walled carbon nanotube s (MWCNTs). (cdc.gov)
Infection with virulent influenza (H5N1) virus was also shown to induce lymphopenia and lymphocyte apoptosis in vivo ( 14 ). (cdc.gov)

Further, oral administration of 50 mg/kg or 100 mg/kg Triphala in PBS, 5 days/week significantly suppressed the growth of Capan-2 pancreatic tumor-xenograft. (biomedcentral.com)
A mouse xenograft model of MCL demonstrated that MLN8237 (10 or 30 mg/kg) or docetaxel (10 mg/kg) alone had modest anti-tumor activity. (elsevierpure.com)
This was followed by repeated selection for increasingly aggressive tumor formation from cells recovered from xenograft tumors in immuno-compromised mice, generating the MCF-10CA1a cell line. (biomedcentral.com)

High levels of miR-184 promotes cell proliferation but inhibits differentiation of aNSCs, whereas inhibition of miR-184 rescued phenotypes associated with MBD1 deficiency. (wikipedia.org)
It has been found that exogenously expressed Numbl could rescue aNSC proliferation and differentiation deficits resulting from either elevated miR-184 or MBD1 deficiency. (wikipedia.org)
The THP-1 DCs had significantly increased expression of cluster of differentiation 11c (CD11c), CD40, CD80, CD83, and CD86, as well as secretion of tumor necrosis factor-alpha. (hindawi.com)
It affects cell proliferation, differentiation and inhibits apoptosis, and its role in tumor development has received attention ( 9 ). (spandidos-publications.com)
Overexpression of IGF-1 in serum and tissue alters the growth of normal cells and causes uncontrolled proliferation, inhibits differentiation and reduces apoptosis, resulting in the incidence and development of malignant tumors ( 10 ). (spandidos-publications.com)
ATRA and 9cis-RA induced morphological changes suggestive of differentiation, while fenretinide induced apoptosis in several cultures tested. (uni-wuerzburg.de)
Microarray analysis of ATRA treated WT cells revealed differential expression of many genes involved in extracellular matrix formation and osteogenic, neuronal or muscle differentiation. (uni-wuerzburg.de)
In addition to being found in plants, IP6 is contained within almost all mammalian cells, where it is important in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation. (naturalnews.com)
In addition to the arresting of cell proliferation, this process also induces the differentiation of malignant cells. (naturalnews.com)
We conclude that by manipulating the composition of the culture medium it is possible to induce canine ADMSCs into insulin-producing cells, and the 2-staged protocol that was used promoted the best differentiation. (sdlifesciences.com)
Here we report on the growth and differentiation properties of these three matched cell lines in three-dimensional basement membrane culture. (biomedcentral.com)

Although histological malignancy of the pituitary is rare, adenomas may exhibit infiltrative and invasive growth patterns characteristic of malignant tumors. (surgicalneurologyint.com)

On the other hand, Triphala failed to induce apoptosis or activate ERK or p53 in normal human pancreatic ductal epithelial (HPDE-6) cells. (biomedcentral.com)

demonstrated that the lipid phosphatase SH2-containing phosphoinositide 5'phosphatase 2 (SHIP2) is a target of miRNA-205 (miR-205) in epithelial cells, and that the corneal epithelial-specific miR-184 can interfere with the ability of miR-205 to suppress SHIP2 levels. (wikipedia.org)
The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye, which acts as a protective barrier and is critical for clear and stable vision. (wjgnet.com)
Our study aimed to determine the inhibitory and also proliferative effects of a methanol plant extract of Siberan ginseng (E. senticosus) on various cancer and normal cell lines including: A-549 (small cell lung cancer), XWLC-05 (Yunnan lung cancer cell line), CNE (human nasopharyngeal carcinoma cell line), HCT-116 (human colon cancer) and Beas-2b (human lung epithelial). (nih.gov)
Next, in CNE (human nasopharyngeal carcinoma cell line) there was a dose dependent proliferative response, whereas in Beas-2 (human lung epithelial cell line), an inhibitory effect. (nih.gov)
HPV promotes latency and consequently does not cause a disease phenotype following initial infection by an immune evasion response reaction, featuring binding to epithelial cells and integrating into the host genome, resulting in the proliferation of epidermal cells containing the viral genome and neovascularization ( 3 ). (spandidos-publications.com)
In this study, we found that the SCARA5 expression was lower in CAL-27 and SCC-9 cells than that in human normal oral epithelial keratinocytes. (degruyter.com)
In addition, SCARA5 repressed OSCC cell epithelial-mesenchymal transformation (EMT), evidenced by increased E-cadherin expression and reduced N-cadherin expression. (degruyter.com)
MCF-10A cells are near diploid and normal human mammary epithelial cells. (biomedcentral.com)
Apoptosis was observed in alveolar epithelial cells, which is the major target cell type for the viral replication. (cdc.gov)
Our data suggest that apoptosis may play a major role in the pathogenesis of influenza (H5N1) virus in humans by destroying alveolar epithelial cells. (cdc.gov)
We previously demonstrated in an autopsy case that alveolar epithelial cells are the major target cell type of this virus ( 3 ). (cdc.gov)
The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)

Cell cycle distribution and apoptosis were detected using flow cytometry. (hindawi.com)
Cell viability/proliferation assays, cell cycle analysis by flow cytometry, immunodetection of specific histone and p53 acetylation marks, western blotting, siRNA and RT-qPCR. (biomedcentral.com)
Cell proliferation was detected by CCK-8 assay cell apoptosis was detected by flow cytometry, cell migration ability was detected by scratch test. (sjos.cn)

6-7 Many of these lethal side effects, plus recurrence of the original tumor, can happen after the "five-year survival" milestone has been achieved. (lifeextension.com)
We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of TRAIL-induced apoptosis induction, long-term tumor cell survival, caspase, and caspase target cleavage. (aacrjournals.org)
Regardless of the tumor heterogeneity, cotreatment with the proteasome inhibitor bortezomib efficiently sensitized all primary glioma samples for TRAIL-induced apoptosis and tremendously reduced their clonogenic survival. (aacrjournals.org)
For example, reduced levels of acetylated H4K16 and trimethylated H4K20 are associated with high tumour grade and poor survival in breast cancer. (biomedcentral.com)
Exposure of Capan-2 cells to the aqueous extract of Triphala for 24 h resulted in the significant decrease in the survival of cells in a dose-dependent manner with an IC50 of about 50 μg/ml. (biomedcentral.com)
Triphala-mediated reduced cell survival correlated with induction of apoptosis, which was associated with reactive oxygen species (ROS) generation. (biomedcentral.com)
However, MLN8237 plus docetaxel demonstrated a statistically significant tumor growth inhibition and enhanced survival compared to single agent therapy. (elsevierpure.com)
Although they account for only 10%-17% of all breast carcinomas ( 1 - 8 ), tumors are often high grade and patients are relatively young and have a reduced breast cancer-specific survival, compared with patients with estrogen receptor- or HER2 / neu -expressing tumors ( 2 , 9 ). (snmjournals.org)
We examined the effects of new formula of freezing solution containing 7.5% dimethylsulfoxide (DMSO) (v/v %) and 2.5% polyethylene glycol (PEG) (w/v %) on cell survival and recovery of hES cells after cryopreservation, and further investigated the role of the combination of Rho-associated kinase (ROCK) inhibitor and p53 inhibitor on cell recovery during the subsequent culture. (ox.ac.uk)
2 3 11 ] Based on our recent demonstration that basal Akt activation increased cellular growth in pituitary adenoma, we herein tested the hypothesis that mTOR activation, downstream from Akt signaling, may increase the growth and survival of pituitary adenoma cells. (surgicalneurologyint.com)
Most of these mutations are either innocuous, having no significant impact on the behavior or survival of the cell, or are deleterious to the cell, dooming it to an early death. (oasisofhope.com)
A stem cell, which has acquired mutations that promote its proliferation and survival, may give rise to a tumor. (oasisofhope.com)

Dense compact collagen, elastic tissue and cartilage are some of the Other instances, because of obstruction of the lymphatics by tissues that are sufficiently proof against invasion by tumour cells, the lymph flow is disturbed and tumour cells tumours. (ehd.org)
Liu Y , Sun M , Zhang B , Zhao W , . KIF18A improves migration and invasion of colorectal cancer (CRC) cells through inhibiting PTEN signaling. (aging-us.com)
In addition, the scratch wound assay and Transwell assay were conducted to detect the effect of KIF18A on the migration and invasion of CRC cells. (aging-us.com)
The results of Western blot illustrated that KIF18A could forward the migration and invasion of CRC cells, and inhibit PTEN , which promoted the activation of PI3K/Akt signaling pathway, thus bringing about the expression of MMP2 and MMP9 . (aging-us.com)
Because colorectal cancer's migration and invasion are one of main factors to the severity of the disease, exploring the molecular mechanisms of proliferation, migration and invasion of CRC cells will contribute to the development of targeted therapy [ 5 ]. (aging-us.com)
It plays a role in proliferation, apoptosis, angiogenesis, and tumor invasion ( 12 - 14 ), and its expression may be related to resistance to cytotoxic-, antiestrogen-, and HER2 / neu -targeted therapy ( 15 - 18 ). (snmjournals.org)
Treatment with celecoxib resulted in G1 cell cycle arrest, induction of apoptosis, inhibition of cellular adhesion and invasion and reduction of expression of hTERT mRNA and COX- 2 protein in all of the ovarian cancer cell lines. (houstonmethodist.org)

Firstly, the overexpression of miRNA‑375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
miR-381-3p overexpression remarkably represses malignant behaviors of papillary thyroid carcinoma cells [ 9 ]. (hindawi.com)
Reduced RA pathway activity and MYCN overexpression were found in high risk tumors as opposed to tumors with low/ intermediate risk, suggesting a beneficial impact of RA especially on advanced WT. (uni-wuerzburg.de)
SCARA5 overexpression significantly inhibited cell proliferation and induced apoptosis of CAL-27 and SCC-9 cells. (degruyter.com)
CRC cell growth induced by C. tropicalis is partially offset in the presence of PD-1 overexpression. (jcancer.org)
While overexpression of gga-miR-155 increased proliferation, decreased the proportion of G1 phase cells relative to that in S and G2 phases, reduced apoptosis rates and increased invasiveness. (biomedcentral.com)
Additionally, the use of simvastatin plus classII histone deacetylase (HDAC) inhibitor (MC1568) induced further overexpression of p27(KIP1) by inhibiting HDAC5 induction originated from downregulated EZH2 in CRC cells and synergistically led to considerable antiproliferative effects. (nih.gov)
Interestingly, HOXA10 was confirmed as a downstream target of RFC4, and the overexpression of HOXA10 attenuated the silencing of RFC4-induced cell proliferation, colony formation inhibition, and cell cycle arrest. (engineering.org.cn)
For chemotherapy drugs, one of the best characterized resistance mechanisms is overexpression of MDR1 , a cell membrane transporter that causes efflux of certain drugs (eg, vinca alkaloids, taxanes, anthracyclines). (msdmanuals.com)

Since hypoxia activates hypoxia-inducible factor (HIF-1)-dependent transcription in cancer cells that, in a paracrine fashion, drive tumor angiogenesis, we investigated the effects of UCN-01 on HIF-1-responsive promoter constructs. (karger.com)
Moreover, the present studies confirm the MMP-13 supplier earlier report that sunitinib inhibited tumor angiogenesis and development in claudin-low TNBC (MDA-MB-231) xenografts, but enhanced percentage of breast cancer stem cells [17].Chinchar et al. (cyp3a-cyp450.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Increased levels of POGLUT2 were found in multiple types of cancer tissues and cell lines. (frontiersin.org)
Our results revealed that RFC4 was more elevated in NPC tumor tissues than in normal tissues. (engineering.org.cn)
Mutations can also arise when DNA is mis-copied or inappropriately distributed during cellular replication - which is one reason why cancers are most prone to spring up from tissues in which cells have been dividing rapidly. (oasisofhope.com)
In benign tumors, the cells have not gained the capacity to spread through healthy tissues and establish new distant colonies (metastases). (oasisofhope.com)
Most common cancers grow slowly compared with normal tissues, and the rate may decrease if tumors are large. (medscape.com)

Here, we investigated the effect of arecoline on the proliferation and migration of human HepG2 hepatoma cells and its potential oncogenic mechanisms. (biomedcentral.com)
Compared with control group, 2.5 µM arecoline treatment increased the proliferation and migration ability of the HepG2 cells. (biomedcentral.com)
A low concentration arecoline can induce the proliferation and migration of HepG2 cells, with the potential mechanism of action linked to high levels of exosomal miR-21 and miR-1267, activation of the PI3K-AKT pathway, upregulation of CDK1 and CCND1, and downregulation of RAF1. (biomedcentral.com)

In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)
Single-cell sequencing is a high-throughput technique that enables detection of genomic, transcriptomic, and epigenomic information at the individual cell level, offering significant advantages in detecting cellular heterogeneity, precise cell classification, and identifying rare subpopulations. (frontiersin.org)
Reductions in cellular proliferation were observed in both cell lines. (naturalnews.com)
Researchers concluded that IP6 decreased cellular growth of these cells by pro-apoptotic mechanisms. (naturalnews.com)
The findings were that IP6 significantly decreased cellular growth and increased late apoptosis in melanoma, suggesting its potential therapeutic value. (naturalnews.com)
Researchers concluded that treatment of pancreatic cancer with IP6 significantly decreased cellular growth and increased apoptosis. (naturalnews.com)
This study also implicated DDC with the cellular energetic status, as DDC silencing reduced the oxidative phosphorylation activity of the cell. (bvsalud.org)
For the first time cellular physiological properties of gliomas (astrocytomas), meningiomas, medulloblastomas and neuronal tumors are compared. (logos-verlag.de)
The upregulation of these currents is accompanied by morphological changes that are characterized by cell rounding and outgrowth of cellular processes. (logos-verlag.de)
As described below, these diverse situations range from the complications of diabetes and cellular perturbation in amyloidoses to immune and inflammatory responses and tumor cell behavior. (jci.org)
Cellular proliferation and growth following exposure to mTOR inhibitors or radiation were assessed using biochemical methods. (surgicalneurologyint.com)
Functionally, the mTOR inhibitors, rapamycin and RAD001 (500 pM-5 nM), induced G1 growth arrest within 24 hours, an effect associated with reduced cellular proliferation. (surgicalneurologyint.com)
Inhibition of mTOR also radiosensitized GH3 cells such that 2.5 Gy in combination with 500 pM rapamycin or RAD001 reduced cellular viability more effectively than 2.5 or 10 Gy alone. (surgicalneurologyint.com)
These data may support a possible therapeutic role for mTOR inhibitors in limiting the cellular proliferation and radioresistance of pituitary adenoma cells. (surgicalneurologyint.com)
Tumors develop when this balance is disrupted by mutations that either boost the rate of cellular multiplication, or that protect the aberrant cell from appropriate programmed death. (oasisofhope.com)
Cellular apoptosis (ie, programmed cell death) is another potential mechanism of many antineoplastic agents. (medscape.com)
The drug leads to single-stranded and double-stranded DNA breaks that arrest cellular proliferation in the late S or early G2 phase of cell cycle. (medscape.com)
These results demonstrate differential sensitivity of standard cytotoxicity assessments on the PPP, thus (1) decoupling 'mitochondrial activity' as an interpretation of cellular formazan and Alamar Blue metabolism, and (2) demonstrating the implicit requirement for investigators to sufficiently verify interaction of these methods in routine cytotoxicity and proliferation characterization. (cdc.gov)
Although older chemotherapeutic drugs are often toxic to normal cells, advances in genetics and cellular and molecular biology have led to development of more selective drugs. (msdmanuals.com)

The THP-1 human monocytic cell line was used as a source of monocytic effector cells for analyzing proliferation and dendritic cell (DC) induction. (hindawi.com)
Several modes of apoptosis induction and responsible viral genes have been proposed ( 8 - 13 ). (cdc.gov)

Tumors were analyzed by immunohistochemistry and western blotting. (biomedcentral.com)
The TAM receptor and ligand expression was evaluated in LMS cell lines and 358 sarcoma samples by either gene expression or immunohistochemistry. (nature.com)
Thus far, studies on IGF-1R expression have been performed mainly on tumor tissue sections using immunohistochemistry. (snmjournals.org)
In the ovarian tumors from obese and non-obese KpB mice, treatment with celecoxib as compared to control resulted in decreased proliferation, increased apoptosis and reduced COX-2 and MMP9 protein expression, as assessed by immunohistochemistry. (houstonmethodist.org)

These may affect tumour growth and also provide an anti-fatigue effect for cancer patients, in particular for those suffering from lung cancer. (nih.gov)
Treatment of A-549 (small cell lung cancer) cells with E. senticosus methanolic extract showed a concentration-dependent inhibitory trend from 12.5 - 50μg/mL, and then a plateau, whereas at 12.5 and 25 μg/mL, there is a slight growth suppression in QBC-939 cells, but then a steady suppression from 50, 100 and 200μg/mL. (nih.gov)
Further, in XWLC-05 (Yunnan lung cancer cell line), E. senticosus methanolic extract displayed an inhibitory effect which plateaued with increasing dosage. (nih.gov)
In recent years, studies have shown that tumor cell-intrinsic PD-1 plays different roles in the development of melanoma, Liver cancer and lung cancer. (jcancer.org)
Here, we showed that hepatocyte growth factor (HGF), a ligand of MET oncoprotein, induces gefitinib resistance of lung adenocarcinoma cells with EGFR -activating mutations by restoring the phosphatidylinositol 3-kinase/Akt signaling pathway via phosphorylation of MET, but not EGFR or ErbB3. (aacrjournals.org)
No increase in lung tumors was observed at 10 or 50 mg/m3. (who.int)

UCN-01, a protein kinase C (PKC) inhibitor, induces growth arrest and apoptosis in cancer cells and was recently introduced in a phase I clinical trial. (karger.com)
Combining autophagy inhibitor with C. tropicalis treatment partly blocked the CRC tumor growth and reversed the downregulation of PD-1. (jcancer.org)
The specific inhibitor tetrodotoxin blocked the Na+- currents by at least 85% in all tumor cells. (logos-verlag.de)
The protein kinase C inhibitor UCN-01 (7-hydroxystaurosporine) has shown higher efficacy against slow proliferating and/or quiescent ovarian cancer cells. (duke.edu)
UCN-01, a kinase inhibitor/mitochondrial uncoupler that has been shown to lead to Puma-induced mitochondrial apoptosis as well as ATP synthase inhibitor oligomycin, demonstrated effectiveness against spheroids, whereas spheroids were refractory to cisplatin and paclitaxel. (duke.edu)
Our objective was to evaluate the effect of the COX-2 inhibitor, celecoxib, on (1) proliferation and apoptosis in human ovarian cancer cell lines and primary cultures of ovarian cancer cells, and (2) inhibition of tumor growth in a genetically engineered mouse model of serous ovarian cancer under obese and non-obese conditions. (houstonmethodist.org)

Because tumor growth is essentially exponential, with one cell dividing into two, two to four, four to eight, and so on, a tumor cell product such as PSA can reflect such exponential growth-measuring the time it takes for PSA to double (PSA doubling time, or PSADT). (lifeextension.com)
10 mg/mL) of Nidus Vespae decoction (NVD) inhibited SGC-7901 gastric cancer cell growth by inducing G2/M cell cycle arrest and apoptosis. (hindawi.com)
Our findings suggest that NVD not only directly inhibits the growth of gastric cancer cells but also exerts indirect antitumor effects by enhancing immune function. (hindawi.com)
We report that, in addition to direct inhibitory effects on endothelial cell growth, UCN-01 abrogates hypoxia-mediated transactivation of HIF-1-responsive promoters in a prostate cancer cell line. (karger.com)
Garcinol treatment alters expression of chromatin modifying enzymes in MCF7 cells, resulting in reprogramming of key histone and p53 PTMs and growth arrest, underscoring its potential as a cancer chemopreventive agent. (biomedcentral.com)
Low level of miR-381-3p constrains oral squamous cell carcinoma growth [ 10 ]. (hindawi.com)
Growth-inhibitory effects of Triphala were evaluated in Capan-2, BxPC-3 and HPDE-6 cells by Sulphoradamine-B assay. (biomedcentral.com)
Reduced tumor-growth in Triphala fed mice was due to increased apoptosis in the tumors cells, which was associated with increased activation of p53 and ERK. (biomedcentral.com)
Promoting PTEN expression in CRC cell lines will stop the activation of the phosphatidylinositol-3-kinase ( PI3K )/sinkserine/threonine kinase ( Akt ) signaling pathway, which affects CRC cell growth, promotes apoptosis, and improves sensitivity to targeted therapy, immunotherapy, and conventional therapy. (aging-us.com)
Our previous studies have found that Candida tropicalis ( C. tropicalis ) can promote CRC tumor growth and chemotherapy resistance to oxaliplatin by regulating mismatch repair system. (jcancer.org)
In this study, we first found that high concentrations of C. tropicalis promote tumor growth in cell cultures and xenografts. (jcancer.org)
Moreover, blocking antibody against PD-1 promotes tumor growth both in SW480 cells and mice CRC xenografts in an adaptive immune-independent manner. (jcancer.org)
NewsTarget) Three recent studies have confirmed the role of inositol hexaphosphate (IP6) in cancer prevention and control of experimental tumor growth. (naturalnews.com)
Cell lines of astrocytomas (1321N1 and A172) show a consistent high expression of voltage-gated Na+-currents after serum deprivation and treatment with nerve growth factor (NGF). (logos-verlag.de)
In this study, tumorigenic potential was assessed using anchorage-independent growth assays and spheroid-forming capacity, which was determined with ovarian cancer cell lines as well as primary ovarian cancers. (duke.edu)
Of 12 cell lines with increased anchorage-independent growth, 8 formed spheroids under serum-free culture conditions. (duke.edu)
To this end, we overexpressed and inhibited gga-miR-155 in an MDV-transformed cell line using mimics and inhibitors respectively, and analyzed their growth, proliferation, apoptosis and invasiveness to explore the possible role of gga-miR-155 in MDV-mediated tumorigenesis. (biomedcentral.com)
Furthermore, the expression of IGF-1R may change in the course of time (e.g., because of tumor growth and therapy). (snmjournals.org)
Our data suggest mTOR promotes pituitary adenoma growth and radioresistance, indicating a possible therapeutic role for mTOR inhibitors in the clinical management of pituitary tumors. (surgicalneurologyint.com)
Rat GH3 and mouse MMQ pituitary adenoma cells (American Type Tissue Collection, Manassas, VA, USA) were cultured in Dulbecco's modified Eagle's medium (DMEM) supplemented with 5% fetal bovine serum, 5% bovine growth serum, and antibiotics in a 37°C humidified incubator at 5% CO 2 . (surgicalneurologyint.com)
GH3 cells are a well-characterized model of secretory adenomas that hypersecrete both prolactin (PRL) and growth hormone (GH) and that reflect the biology of human secretory tumors. (surgicalneurologyint.com)
We suggest that these network interactions serve to modulate growth and metabolism at the transcriptional level in order to balance nutrient demand with supply, to maintain growth homeostasis, and to influence cell fate. (engineering.org.cn)
Some of these "oncogenic" (cancer-causing mutations) boost the intensity of growth signals that cause the cell to multiply, or disable key proteins that restrain these growth signals. (oasisofhope.com)
That is because many mutations that boost growth signals are somehow "sensed" by the cell as abnormal, inducing the cell to commit suicide. (oasisofhope.com)
But, this protective apoptotic response can sometimes be "vetoed" if the cell is exposed to excessive levels of certain growth-promoting hormones that suppress apoptosis. (oasisofhope.com)
Therefore, it is used in almost all protocols in the hope that it will decrease any autonomous hormone production and suppress tumor growth. (medscape.com)
These agents inhibit cell growth and proliferation. (medscape.com)
Cancer chemotherapy is based on an understanding of tumor cell growth and how drugs affect it. (medscape.com)
After cells divide, they enter a period of growth (phase G1), followed by DNA synthesis (phase S). The next phase is a premitotic phase (phase G2). (medscape.com)
External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)

MicroRNAs (miRNAs) act as oncogenes or tumor suppressors in most cancers. (biomedcentral.com)
In particular we use tightly integrated computational and experimental, multi-omic approaches to discover the processes underlying how cells behave (or misbehave) and accordingly how cancers develop and grow. (stanford.edu)
Some mutations, often observed during the early evolution of cancers, increase the propensity of cells to accumulate further mutations. (oasisofhope.com)
Pre-cancerous cells - as well as fully evolved cancers - tend to be very genetically labile. (oasisofhope.com)
Such cells are prone to give rise to full-blown cancers, which may be relatively difficult to kill with chemotherapy or radiation. (oasisofhope.com)
Single drugs may cure selected cancers (eg, choriocarcinoma, hairy cell leukemia). (msdmanuals.com)

However, the regulatory mechanisms of HPV infection and consequent immune escape reaction, persistent infection and cell proliferation and the regulatory mechanisms of vascular proliferation are poorly understood and require additional investigation ( 4 ). (spandidos-publications.com)
It unlocks novel dimensions by uncovering elusive cell populations and tumor heterogeneities for early detection, unraveling mechanisms of treatment resistance, tailoring therapies to individuals, and illuminating metastasis and cachexia pathways, thereby opening fresh avenues for preventive strategies. (frontiersin.org)
The aim of this study was to analyze the effects of gga-miR-155 on the proliferation, apoptosis and invasiveness of an MDV-transformed lymphocyte line MSB1 and elucidate the underlying mechanisms. (biomedcentral.com)
Fortunately, cells have mechanisms for repairing damaged DNA - but these mechanisms are less than perfect, so that permanent alterations of DNA structure are progressively acquired by stem cells. (oasisofhope.com)

6/7 primary cultures tested reduced proliferation, irrespective of prior RA signaling levels. (uni-wuerzburg.de)

Triple-negative breast tumors are estrogen receptor-, progesterone receptor-, and HER2 / neu -negative. (snmjournals.org)

Furthermore, the supernatant of THP-1 DCs significantly inhibited the proliferation of gastric cancer cells by inducing apoptosis and G1/S cell cycle arrest. (hindawi.com)
Crizotinib and foretinib decreased TYRO3 and AXL phosphorylation, apoptosis, G2/arrest and reduced colony formation. (nature.com)
MCF-10AT cells grown in three-dimensional basement membrane culture form complex multi-acinar structures that produce a basement membrane but undergo delayed cell cycle arrest and have incomplete luminal development. (biomedcentral.com)

All-trans-retinoic acid induces miR-184 expression in neuroblastoma cell line and ectopic miR-184 causes apoptosis. (wikipedia.org)
The programmed cell death 1 (PD-1) receptor is an immune checkpoint molecule that induces immune tolerance and mediates the immune escape of tumor cells. (jcancer.org)
the iron-doxorubicin complex induces the production of free radicals that can destroy DNA and cancer cells. (medscape.com)

Cell viability was detected by the Cell Counting Kit-8 (CCK-8) assay. (hindawi.com)
When being treated with 2% DMSO in culture medium, Hepa1-6 cells showed depressed proliferation with no significant apoptosis or decreased viability. (oncotarget.com)

Triphala-induced apoptosis was linked with phosphorylation of p53 at Ser-15 and ERK at Thr-202/Tyr-204 in Capan-2 cells. (biomedcentral.com)

In contrast to cell lines, isolated primary tumor cells from all investigated glioma patients were highly TRAIL resistant. (aacrjournals.org)

Above mentioned effects were significantly blocked when the cells were pretreated with an antioxidant N-acetylcysteine (NAC), suggesting the involvement of ROS generation. (biomedcentral.com)
Pretreatment of cells with pifithrin-α or U0126, specific inhibitors of p53 or MEK-1/2, significantly attenuated Triphala-induced apoptosis. (biomedcentral.com)
In the present study, we demonstrate that Triphala significantly inhibit the proliferation of Capan-2 and BxPC-3 human pancreatic cancer cells. (biomedcentral.com)
In our previous study, miRNA-183, a miRNA in the miR-96-182-183 cluster, was significantly over-expressed in esophageal squamous cell carcinoma (ESCC). (molcells.org)

Regardless of the therapeutic approach, the heterogeneity of pancreatic cancer cells and the complexity of its tumor microenvironment contribute to the emergence of drug resistance. (frontiersin.org)
Immune infiltration and tumor microenvironment evaluations were assessed by ImmuneScore, ImmuCellAI, and TIMER databases. (frontiersin.org)
POGLUT2 was mainly expressed in stromal cells as verified by StromalScore, ESTIMATEScore, ImmuneScore, and Tumor purity, and POGLUT2 was positively correlated with cancer-associated fibroblasts, macrophages, monocytes, and neutrophils in the tumor microenvironment. (frontiersin.org)
The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)

The current investigation aimed to demonstrate how interpretation of results from several standard cytotoxicity and proliferation assays vary in dependence on contributions from the pentose phosphate pathway (PPP). (cdc.gov)
Non-tumorigenic Beas-2B cells were treated with graded concentrations of benzo[a]pyrene (B[a]P) for 24 and 48h prior to cytotoxicity and proliferation assessment with commonly used MTT, MTS, WST1, and Alamar Blue assays. (cdc.gov)

Qu J, Chen Q, Bing Z, Shen S, Hou Y, Lv M, Wang T. C. tropicalis promotes CRC by down-regulating tumor cell-intrinsic PD-1 receptor via autophagy. (jcancer.org)
Mechanistically, we found that C. tropicalis modulates the expression of PD-1 via increasing the autophagy traffic in colon cancer cells. (jcancer.org)
As dopamine affects autophagy in neuronal cells, we investigated the possible association of DDC with autophagy in human hepatocytes and examined whether DDC mediates the relationship between DENV infection and autophagy. (bvsalud.org)
We also report that upon DDC silencing, the repressive effect of DENV on the completion of autophagy was enhanced, and the inhibition of autolysosome formation did not exert an additive effect on viral proliferation. (bvsalud.org)

Interestingly, tumors from D-hep cells, not Hepa1-6 cells, regressed in wild-type C57BL/6 mice whereas D-hep cells exhibited similar tumorigenesis as Hep1-6 cells in immunodeficient mice. (oncotarget.com)
As expected, additional Hepa1-6 cells failed to form tumors in the D-hep-C57 mice in which D-hep cells were eliminated. (oncotarget.com)
Further research confirmed that D-hep-C57 mice established anti-tumor immunity against Hepa1-6 cells. (oncotarget.com)
When inoculated subcutaneously into the flanks of immuno-compromised mice, MCF-10AT cells occasionally form tumors, whereas MCF-10CA1a cells invariably form tumors with a shorter latency than MCF-10AT derived tumors. (biomedcentral.com)
111 In-R1507 SPECT and 89 Zr-R1507 PET images of mice with subcutaneous SUM149 tumors were acquired at 1, 3, and 7 d after injection. (snmjournals.org)
In the KpB mice fed a high fat diet (obese) and treated with celecoxib, tumor weight decreased by 66% when compared with control animals. (houstonmethodist.org)
Among KpB mice fed a low fat diet (non-obese), tumor weight decreased by 46% after treatment with celecoxib. (houstonmethodist.org)

Spheroids exhibit drug resistance and slow proliferation, suggesting involvement in cancer recurrence. (duke.edu)

The gga-miR-155 promotes the proliferation and invasiveness of the MDV-transformed lymphocyte line MSB1 and inhibits apoptosis by targeting the RORA gene. (biomedcentral.com)

The present work contains an analysis of voltage-dependent Na+-, Ca2+- and K+-channels in brain tumor cells of different origin. (logos-verlag.de)
Pituitary adenomas are the most frequent brain tumor in adults. (surgicalneurologyint.com)

Design and Methods We evaluated biopsies from 19 patients with primary cutaneous CD30+ lymphoproliferative disorders, 38 with ALK- and 33 with ALK+ systemic anaplastic large cell lymphoma. (uni-wuerzburg.de)

showed that Methyl-CpG binding protein 1 (MBD1) regulates the expression of several miRNAs in adult neural stem/progenitor cells (aNSCs) and, specifically, that miR-184 is directly repressed by MBD1. (wikipedia.org)
Numblike (Numbl) is known to be important in embryonic neural stem cell function and cortical brain development and has been identified as a downstream target of miR-184. (wikipedia.org)
Finally, a recent study identified miR-184 as essential for embryonic corneal commitment of pluripotent stem cells. (wikipedia.org)
The aim of this study was to differentiate canine adipose-derived mesenchymal stem cells (ADMSCs) into insulin-producing cells by using culture media with different compositions to determine the most efficient media. (sdlifesciences.com)
Adipose-derived mesenchymal stem cells from groups 1 to 5 gradually became round in shape and gathered in clusters. (sdlifesciences.com)
Enhancement of cell recovery for dissociated human embryonic stem cells after cryopreservation. (ox.ac.uk)
Due to widespread applications of human embryonic stem (hES) cells, it is essential to establish effective protocols for cryopreservation and subsequent culture of hES cells to improve cell recovery. (ox.ac.uk)
Throughout life, the human body accumulates mutations in the genetic material of its stem cells - cells that retain the capacity to divide. (oasisofhope.com)
Fortunately, a high proportion of stem cells that have acquired potentially oncogenic mutations die off before they can do any harm. (oasisofhope.com)

1 Prostate-specific antigen is a protein produced by the cells of the prostate gland, including both cancerous cells as well as cells that are benign. (lifeextension.com)
Although histologically benign, pituitary tumors cause significant morbidity and mortality. (surgicalneurologyint.com)
Unless they arise in places where surgery is impractical - certain brain tumors, for example - most benign tumors are little more than a nuisance that can be surgically removed if need be. (oasisofhope.com)

Therefore, targeting drugs molecules in the PTEN signaling pathway may be another strategy to suppress tumor cells by inhibiting tumor activity [ 7 , 8 ]. (aging-us.com)

With increasing globalization and advancements in modern medicine, novel therapeutic approaches such as targeted molecular therapy [ 4 ], immunotherapy [ 5 ], and latent/residual tumor cell ablation have been used to improve clinical outcomes for cancer patients, but the prognosis for patients with gastric cancer remains poor. (hindawi.com)

However, with the development of immunology, western scientists are gradually realizing the importance of homeostasis in the human body, especially immune balance in tumor patients [ 9 ]. (hindawi.com)
Imbalance of the immune system can lead to the development of tumors. (hindawi.com)
In addition to the balance between tumors and the immune system, there is also a balance between tumors and the nonimmune cells that surround them [ 10 ]. (hindawi.com)
Thus, both the ability of antitumor drugs to kill tumor cells and their effects on immune function and normal tissue cells should be studied. (hindawi.com)
There is some evidence that a carbohydrate in Siberian ginseng may possess not only immune stimulatory but also anti-tumour effects and also display other various anti-cancer properties. (nih.gov)
It is mainly expressed in immune cells such as T cells, B cells and monocytes. (jcancer.org)
It is mainly expressed on mature cytotoxic T lymphocytes [ 7 , 8 ], and it can inhibit T cell function by binding with PD-L1 or PD-L2 ligand, which is mainly expressed on the surface of tumor cells, to induce immune tolerance and limit autoimmunity [ 9 ]. (jcancer.org)
Analysis of this network shows that it recapitulates known features of the human immune system and can be used uncover novel multi-step immune pathways, examine species-specific differences in immune processes, and predict the response of immune cells to stimuli. (stanford.edu)
Even if incipient cancer cells manage to avoid self-induced apoptosis, they are often prone to attack by marauding "natural killer" immune cells, which can recognize them as the enemy. (oasisofhope.com)
Whether observed apoptotic cells were a direct result of the viral replication or a consequence of an overactivation of the immune system requires further studies. (cdc.gov)

Several forms of cancer (see below) including elevation of miR-184 levels in squamous cell carcinoma of the tongue. (wikipedia.org)
Oral squamous cell carcinoma (OSCC) is a common tumor in the world. (degruyter.com)
ABSTRACT Diet has not been investigated as a potential risk factor for head and neck squamous cell carcinomas in the Syrian Arab Republic. (who.int)
Head and neck squamous cell carcino- receive treatment. (who.int)

D-hep cells, Hepa1-6 cells treated with DMSO for 7 days, could restore to the higher proliferation rate in DMSO-free medium, but alteration of gene expression profile was irreversible. (oncotarget.com)

Finally in colon cancer cell line (HCT-116) we observed an initially weak inhibitory effect and then plateau. (nih.gov)
As published in Oncology Research , February 2008, researchers reported that IP6 was shown to have significant inhibitory effects against a variety of primary tumors. (naturalnews.com)
As published in Journal of Surgical Research , June 2005, researchers reported that IP6 has been found to have significant inhibitory effects against a variety of primary tumors including breast and colon. (naturalnews.com)

To investigate the mechanism of curcumin targeting miR-155-5p/TP53INP1 axis to induce oxidative stress to regulate salivary gland tumor cell proliferation and apoptosis. (sjos.cn)
Curcumin targeting miR-155-5p/TP53INP1axis induced oxidative stress to regulate salivary gland tumor cell proliferation, apoptosis[J]. Shanghai Journal of Stomatology, 2022, 31(5): 483-490. (sjos.cn)

showed that miR-184 mediates NFAT1 translational regulation in umbilical cord blood (UCB) graft CD4+ T-cells leading to blunted allogenic responses. (wikipedia.org)
Due to the pleiotropic effect of bortezomibenhanced TRAIL DISC formation upon TRAIL triggering, down-regulation of cFLIP L and activation of the intrinsic apoptosis pathway seem to cooperatively contribute to the antitumor effect of bortezomib/TRAIL cotreatment. (aacrjournals.org)
Aufgrund ihrer hohen Expression und dynamischen Regulation in Hirntumorzellen können spannungsabhängige Ionenkanäle als Indikatoren für die Untersuchung wichtiger tumorbiologischer Mechanismen dienen, wie der Proliferation, Differenzierung, Apoptose und Invasivität. (logos-verlag.de)

In the present study, we investigated the therapeutic potential of TRAIL in primary human glioma cells. (aacrjournals.org)
Together, our results suggest that MLN8237 plus docetaxel may represent a novel therapeutic strategy that could be evaluated in early phase trials in relapsed/refractory aggressive B-cell NHL. (elsevierpure.com)

Slow growing tumor cells - astrocytoma cells during serum deprivation and neuronal tumor cells of the neurocytoma and the DNT - showed the highest density of Na+-currents. (logos-verlag.de)
High-glucose Dulbecco's modified Eagle medium ( HG - DMEM ) supplemented with 20% fetal bovine serum followed by HG - DMEM with 2% horse serum is found to enable proliferation of both C2C12 muscle precursor cells and TE85 human osteosarcoma cells, fusion of C2C12s into myotubes, as well as an upregulation of RUNX2/CBFa1 in TE85s. (sdlifesciences.com)
Celecoxib strongly decreased the serum level of VEGF and blood vessel density in the tumors from the KpB ovarian cancer mouse model under obese and non-obese conditions. (houstonmethodist.org)

From this it is concluded that NGF controls voltage- gated Na+-channels in astrocytoma cells by autocrine stimulation. (logos-verlag.de)

According to Dr. Shamsuddin, when IP6 is administered it is rapidly taken into the cells and dephosphorylated to lower inositol phosphates, which further affect signal transduction pathways. (naturalnews.com)

The expression level of gga-miR-155 was manipulated in MSB1 cells using specific mimics and inhibitors. (biomedcentral.com)
To assess the effect of mammalian target of rapamycin (mTOR) inhibition on pituitary adenoma cells, rat GH3 or MMQ cells were treated with the clinically useful mTOR inhibitors, rapamycin or RAD001. (surgicalneurologyint.com)

2 If PSA readings begin to elevate, there are interventions that can reduce or stabilize the production of PSA, shutting down a mechanism used by cancer cells to escape their confinement within the prostate gland. (lifeextension.com)
Globally, gastric cancer remains a serious threat to human health given its high morbidity and mortality [ 1 - 3 ], and tumor treatment continues to be an important issue in modern medicine. (hindawi.com)
The mortality rate for those diagnosed with head and neck cancer (which does not include brain tumors) is high. (lifeextension.com)
We conclude that UCN-01, at clinically relevant concentrations, exerts an anti-neovascularization effect by blocking two important steps in vessel formation: (1) the response of cancer cells to hypoxia, and (2) endothelial cell proliferation. (karger.com)
Drug-like molecules that can reprogram selected histone PTMs in tumour cells are therefore of interest as potential cancer chemopreventive agents. (biomedcentral.com)
In this study we assessed the effects of the phytocompounds garcinol and curcumin on histone and p53 modification in cancer cells, focussing on the breast tumour cell line MCF7. (biomedcentral.com)
In summary, although garcinol and curcumin can both inhibit histone acetyltransferase activities, our results show that these compounds have differential effects on cancer cells in culture. (biomedcentral.com)
Thus, drug-like molecules that target chromatin modifying enzymes to reprogram selected histone PTMs in tumour cells may have potential as cancer chemopreventive agents. (biomedcentral.com)
To conclude, it was identified that the probable anti‑CA mechanism of miRNA‑375 modulates HPV through the UBE3A and IGF‑1R pathway in cervical cancer cells. (spandidos-publications.com)
UBE3A is associated with cervical cancer and may combine with the E6 proto-oncogene encoded by HPV16 within cervical cancer cells to form the E6/E6-AP protein complex through the ubiquitin proteasome pathway ( 4 ). (spandidos-publications.com)
Previous studies have identified that UBE3A exhibits abnormal expression in numerous tumor cells, including prostate, cervical and breast cancer ( 6 , 7 ). (spandidos-publications.com)
Similarly, Triphala induced apoptosis in another pancreatic cancer cell line BxPC-3 by activating ERK. (biomedcentral.com)
Overall, single-cell sequencing has immense potential in promoting early diagnosis, guiding personalized treatment, and preventing complications of pancreatic cancer. (frontiersin.org)
Emerging single-cell sequencing technologies will undoubtedly enhance our understanding of the complex biology of pancreatic cancer and pave the way for new directions in its clinical diagnosis and treatment. (frontiersin.org)
Applications of single-cell sequencing technology in the diagnosis and treatment of pancreatic cancer. (frontiersin.org)
Single-cell sequencing technology transforms the landscape of pancreatic cancer diagnosis and therapy. (frontiersin.org)
However, the expression and function of PD-1 in colon cancer cells has not been reported. (jcancer.org)
In addition, we proved that colon cancer cell lines express PD-1 receptors. (jcancer.org)
We also demonstrated that high concentrations of C. tropicalis can down-regulate tumor cell-intrinsic PD-1 expression in colon cancer cells. (jcancer.org)
Two pancreatic cancer cell lines were cultured and treated with IP6. (naturalnews.com)
As previous known, the more differentiated the malignant cells, the less aggressive and dangerous is the cancer. (naturalnews.com)
Universal features of breast cancer include a loss of control of cell proliferation and organization, a loss of cell polarity, as well as a loss of cell: cell adhesion and cell: basement membrane adhesion. (biomedcentral.com)
Expression, gene mutation and amplification, methylation, and copy number alteration (CNA) of POGLUT2 were evaluated using The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), and Genotype-Tissue Expression (GTEx) databases. (frontiersin.org)
In the present study, we explored the oncogenic roles of miR-183 in ESCC by gain and loss of function analysis in an esophageal cancer cell line (EC9706). (molcells.org)
Celecoxib inhibited cell proliferation in three ovarian cancer cell lines and five primary cultures of human ovarian cancer after 72 hours of exposure. (houstonmethodist.org)
Dans une étude cas-témoins non appariés en milieu hospitalier, 108 personnes atteintes d'un cancer et 105 témoins ont été interrogés sur leurs apports alimentaires en recourant à la version en langue arabe d'un questionnaire validé sur la fréquence de consommation alimentaire. (who.int)
Загальні відомості про терапію злоякісних новоутворень Curing cancer requires eliminating all cells capable of causing cancer recurrence in a person's lifetime. (msdmanuals.com)
The ideal drug would target only cancer cells and have no adverse effects on normal cells. (msdmanuals.com)
Cytotoxic drugs damage DNA and kill many normal cells as well as cancer cells. (msdmanuals.com)
In contrast, other drugs (eg, DNA cross-linkers, also known as alkylating agents) have a linear dose-response relationship, killing more cancer cells at higher doses. (msdmanuals.com)
Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)

0.05) either for feeder-dependent or feeder-independent culture. (ox.ac.uk)

NGF modulates functional properties of Na+-channels in both astrocytoma and neuroblastoma cells. (logos-verlag.de)

These DE-miRNAs, hub genes and pathway were proved in arecoline-treated HepG2 cells. (biomedcentral.com)

Auroras (A and B) are oncogenic serine/threonine kinases that play key roles in the mitotic phase of the eukaryotic cell cycle. (elsevierpure.com)
In interfering with cell reproduction, some antineoplastic agents are specific to certain phases of the cell cycle, whereas others (eg, alkylating agents, anthracyclines, cisplatin) are not phase specific. (medscape.com)
Doxorubicin's maximum toxicity occurs during the S phase of cell cycle. (medscape.com)
Antimetabolites such as fluorouracil and methotrexate are cell cycle-specific and have a nonlinear dose-response relationship. (msdmanuals.com)
Continuous infusion may increase cell kill with some cell cycle-specific drugs (eg, fluorouracil). (msdmanuals.com)

This difference allows healthy cells to recover from chemotherapy more quickly than do malignant cells, and this is the rationale for current cyclic dosage schedules. (medscape.com)

Pituitary tumors are among the most prevalent brain tumors in adults and may be associated with significant morbidity and mortality. (surgicalneurologyint.com)

Therefore, detecting the expression of IGF-1 assists in determining the biological behavior of tumors ( 10 ). (spandidos-publications.com)
In this work, we confirmed that overexpressed miR-381-3p repressed biological functions of glioma cells. (hindawi.com)
Investigating the histological characteristics of CRC is conducive to the research of the biological characteristics of tumors. (aging-us.com)

Anatomy27

Organisms10

Diseases56

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes48

Disciplines and Occupations1

Information Science3

Health Care2

Vitro19

Progression14

Suppressor4

Vivo8

Xenograft3

Differentiation11

Malignant tumors1

Induce apoptosis1

Epithelial12

Flow cytometry3

Survival12

Invasion7

Overexpression11

Angiogenesis2

Tissues6

Migration3

Cellular19

Induction2

Immunohistochemistry4

Lung6

Inhibitor6

Growth30

Cancers6

Mechanisms4

Tested reduced proliferation1

Breast tumors1

Arrest3

Induces3

Viability2

Phosphorylation1

Primary tumor1

Significantly4

Microenvironment4

Assays2

Autophagy4

Mice7

Resistance1

Promotes1

Brain tumor2

Methods1

Stem9

Benign3

Suppress tumor1

Immunotherapy1

Immune10

Squamous4

Gene expression1

Inhibitory3

Oxidative2

Regulation3

Therapeutic2

Serum3

Astrocytoma Cells1

Signal transduction1

Inhibitors2

Cancer31

0.051

Neuroblastoma1

Pathway1

Cycle5

Chemotherapy1

Morbidity and morta1

Biological3