• Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
  • Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
  • Cancer Network spoke with Sheila A. Stewart, PhD, on how age-related changes in the tumor microenvironment may impact progression and metastasis. (cancernetwork.com)
  • Figure 1 The immune cells in the tumor microenvironment regulate liver cancer progression. (wjgnet.com)
  • Figure 2 Metabolites in the tumor microenvironment affect the anti-/pro-tumoral functions of immune cells. (wjgnet.com)
  • Hwang's lab found DKK3 to be highly expressed in pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer , and specifically by PSCs rather than cancer cells, and her team discovered different ways to silence DKK3 from acting on cancer cells as well as immune cells in the tumor microenvironment. (medicalxpress.com)
  • We hypothesized that antibiotic-induced dysbiosis of the gut microbiota would suppress cytokine profiles in the host, thereby leading to changes in the tumor microenvironment. (aacrjournals.org)
  • In order to improve the tissue hypoxia in the tumor microenvironment, it is required to normalize very leaky and immature tumor vasculature. (nii.ac.jp)
  • Analysis of immune biomarkers will focus on Jak2/STAT3 driven processes such as the percentage of MDSC, T cell subset analysis and inflammatory cytokines both systemically and in the tumor microenvironment. (bmj.com)
  • However, the mechanism through which RAD18 influences triple-negative breast cancer (TNBC), especially the interaction between tumor cells and the tumor microenvironment, remains elusive. (nature.com)
  • Tumor microenvironment (TME) remodeling is a critical process in primary tumor progression. (nature.com)
  • My research is focused on cellular crosstalk in the tumour microenvironment leading to metastasis formation. (essex.ac.uk)
  • Vascular endothelial profilin-1 drives a protumorigenic tumor microenvironment and tumor progression in renal cancer. (bvsalud.org)
  • In conclusion, this study demonstrates for the first time a direct causal relationship between vascular endothelial Pfn1 dysregulation, immunosuppressive tumor microenvironment , and disease progression with mechanistic insights in kidney cancer . (bvsalud.org)
  • Here, we investigated the role of tight-junction protein 1 (TJP1), a membrane-associated intercellular barrier protein during the development of LMS and the tumor microenvironment. (molcells.org)
  • Tissues from mice were stained and further analyzed to clarify the effects of TJP1 expression on tumor development and the tumor microenvironment. (molcells.org)
  • Further analysis revealed two clusters related to cell proliferation and the tumor microenvironment. (molcells.org)
  • Taken together, these results imply that TJP1 contributes to the development of sarcoma by proliferation through modulating cell-cell aggregation and communication through cytokines in the tumor microenvironment and might be a beneficial therapeutic target. (molcells.org)
  • To date, PA imaging has mainly been developed for measuring oxygen saturation mainly in phantoms and numerous preclinical studies in animals have exploited the oxygenated and deoxygenated hemoglobin components to characterize tumour microenvironment. (lu.se)
  • Such melanomas are not associated with metastasis, and it is hypothesized that such tumors do not have competence for metastasis. (nih.gov)
  • For a melanoma to acquire competence for metastasis it must progress to the next step of tumor progression--the vertical growth phase. (nih.gov)
  • Cancer progression is commonly thought of as a process involving the growth of a primary tumor followed by metastasis, in which cancer cells leave the primary tumor and spread to distant organs. (mskcc.org)
  • The findings of the study, published in the December 25 issue of the journal Cell, suggest that self-seeding can enhance tumor growth through the release of signals that promote angiogenesis, invasion, and metastasis. (mskcc.org)
  • Evidence points to a role for c-Met and RON signaling in tumor progression by increasing proliferation, inhibiting apoptosis, contributing to angiogenesis, promoting metastasis and in maintenance of cancer stem cells [ 11 - 14 ]. (oncotarget.com)
  • Erratum to: The effect of soluble E-selectin on tumor progression and metastasis [BMC Cancer. (nus.edu.sg)
  • Pet dogs naturally develop osteosarcoma providing a novel opportunity to model metastasis development and progression. (biomedcentral.com)
  • Given the accelerated biology of canine osteosarcoma, we hypothesized that a direct comparison of canine and pediatric osteosarcoma expression profiles may help identify novel metastasis-associated tumor targets that have been missed through the study of the human cancer alone. (biomedcentral.com)
  • Furthermore, while overexpression of ITCH expression in breast cells is associated with increased incidence of mammary tumor formation and progression, its knockdown inhibited breast cancer cell tumorigenicity and metastasis. (oncotarget.com)
  • We hypothesized that disruption of the Merlin-CD44 complex through loss of Merlin, unleashes putative tumor- or metastasis-promoting functions of CD44. (uni-luebeck.de)
  • Tumor cells can utilize platelets to promote their own infiltration and hematogenous metastasis, and platelets are activated and aggregated in this process. (qxmd.com)
  • This is of great significance for predicting tumor metastasis before timely treatments. (qxmd.com)
  • The researchers developed an antibody to block the DKK3 molecule in mice, which not only inhibited tumor growth but also significantly prolonged life. (medicalxpress.com)
  • As with many targeted agents used to treat solid tumors, it is likely that c-Met/RON inhibitors will have greater benefit when used in combination with chemotherapy or other targeted agents. (oncotarget.com)
  • TEPs are involved in the progression and spread of several solid tumors, and spliced TEP RNA surrogate signatures can provide specific information on the presence, location, and molecular characteristics of cancers. (prinsesmaximacentrum.nl)
  • Disruption of the centrosome is common in many solid tumors including lung cancer. (cdc.gov)
  • Tm1 is also a major tumor suppressor in breast cancer. (scirp.org)
  • In the present study, we investigated the role of phosphorylation of Tm1 in regulating its tumor suppressor properties. (scirp.org)
  • Zerradi, M. , Houle, F. and Huot, J. (2015) Regulation of Breast Cancer Progression by Phosphorylation of the Tumor Suppressor Tropomyosin-1 Alpha. (scirp.org)
  • Lee, E.Y. and Muller, W.J. (2010) Oncogenes and Tumor Suppressor Genes. (scirp.org)
  • Together, our results reveal that ITCH pro-tumorigenic functions in breast cancer are mediated, at least in part, through inactivation of the Hippo tumor suppressor pathway. (oncotarget.com)
  • Merlin is a versatile tumor suppressor protein encoded by the NF2 gene. (uni-luebeck.de)
  • Several lines of evidence suggest that Merlin exerts its tumor suppressor activity, at least in part, by forming an inhibitory complex with cluster of differentiation 44 (CD44). (uni-luebeck.de)
  • Cancer initiation, promotion, and progression and the acquisition of key behavioral traits. (wikipedia.org)
  • Progression entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public domain material from Dictionary of Cancer Terms. (wikipedia.org)
  • Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
  • The Importance of Monitoring Mesothelioma Tumor Progression Pleural mesothelioma is a rare cancer with a grim prognosis. (survivingmesothelioma.com)
  • A new study by researchers at Memorial Sloan Kettering Cancer Center shows that circulating tumor cells - cancer cells that break away from a primary tumor and disseminate to other areas of the body - can also return to and grow in their tumor of origin, a newly discovered process called "self-seeding. (mskcc.org)
  • Our work not only provides evidence for the self-seeding phenomenon and reveals the mechanism of this process, but it also shows the possible role of self-seeding in tumor progression," said the study's first author Mi-Young Kim, PhD, Research Fellow in the Cancer Biology and Genetics Program at Memorial Sloan Kettering. (mskcc.org)
  • Depletion of DKK3 in a mouse model of pancreatic cancer reduces proliferating tumor cells and prolongs survival by more than double. (medicalxpress.com)
  • Researchers at The University of Texas MD Anderson Cancer Center have shed new light on why pancreatic tumors are so resistant to therapy. (medicalxpress.com)
  • Central to the discussion is Dr. Yates's groundbreaking work as principal investigator of MET-PAAM, studying the molecular mechanisms of tumor progression in metastatic prostate cancer among men of African descent. (urotoday.com)
  • In terms of malignant transformation in cancer cells, interaction of cancer stem cells with endothelial cells or myofibroblasts as tumor microenvironmental cells was analyzed. (nii.ac.jp)
  • As a result, when tumor vasculature was focused, we found that cancer stem cells existing near myofibroblasts abundantly localizing at perivascular area show drug resistance. (nii.ac.jp)
  • The melatonin suppression caused by the pinealectomy might contribute to oral cancer development by acting on ERK1/2 and p53 pathways and regulating tumor inflammation. (unesp.br)
  • The features of cancers in pet dogs that may uniquely contribute to our understanding of cancer pathogenesis, progression and therapy have been recently reviewed [ 4 ]. (biomedcentral.com)
  • Inhibition of YAP or TGF-β breaks this loop and suppresses cancer stemness and proliferation In nude mice, RAD18 promoted subcutaneous transplanted tumor growth and M2-type TAM recruitment. (nature.com)
  • Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)
  • Tumor markers are not elevated in all cancer patients, particularly patients with early-stage cancer. (medscape.com)
  • Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
  • Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
  • No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
  • However, recent studies have suggested that a plant-based diet may have a role to play in slowing the progression of advanced prostate cancer. (naturallipomatreatment.com)
  • A preliminary study by Dr. Dean Ornish showed that a plant-based diet and lifestyle program could apparently reverse the progression of prostate cancer by making men's bloodstream nearly 8 times better at suppressing cancer cell growth. (naturallipomatreatment.com)
  • Can a Plant-Based Diet Slow the Progression of Cancer? (naturallipomatreatment.com)
  • While there are many treatments available, researchers are now exploring the potential of diet and lifestyle changes as a way to slow or even reverse the progression of prostate cancer. (naturallipomatreatment.com)
  • In fact, a whole food, plant-based diet may be one of the best ways to help slow the progression of advanced prostate cancer. (naturallipomatreatment.com)
  • In a study conducted at UC San Diego, researchers found that eating a whole food, plant-based diet could help slow the progression of advanced prostate cancer. (naturallipomatreatment.com)
  • Senotherapy," a treatment that uses small molecule drugs to target "senescent" cells, or those cells that no longer undergo cell division, blunts liver tumor progression in animal models according to new research from a team led by Celeste Simon, Ph.D., a professor of Cell and Developmental Biology in the Perelman School of Medicine at the University of Pennsylvania and scientific director of the Abramson Family Cancer Research Institute. (news-medical.net)
  • Sunitinib malate is approved by the Food and Drug Administration (FDA) to treat a type of stomach cancer called gastrointestinal stromal tumor (GIST). (news-medical.net)
  • So far, TEP samples from patients with different tumor types, including lung, brain, and breast cancers, have been tested, and it has been shown that TEPs from patients with cancer are distinct from those with inflammatory and other noncancerous diseases. (prinsesmaximacentrum.nl)
  • We compare clinical characteristics of prostate cancer tumors diagnosed within WTCHP with those characteristics of an age-matched group of prostate cancers who are not related to WTC. (cdc.gov)
  • To compare DNA methylation as a marker of tumor aggressiveness in WTCHP prostate cancer patients and in matched prostate cancers not related to WTC. (cdc.gov)
  • As the cancer progresses, cancer cells from the tumor can break away and spread to other parts of the body through the bloodstream or lymph system . (medlineplus.gov)
  • When cancer spreads, tumors can form in other organs and parts of the body. (medlineplus.gov)
  • Cancer staging is used to help describe the progression of cancer. (medlineplus.gov)
  • The most common system for staging a cancer that is a solid tumor is the TNM system. (medlineplus.gov)
  • As an example, a bladder cancer T3 N0 M0 means there is a large tumor (T3) that has not spread to lymph nodes (N0) or anywhere else in the body (M0). (medlineplus.gov)
  • This is because some cancers, particularly blood and bone marrow cancer such as leukemia, do not form tumors or spread in the same way. (medlineplus.gov)
  • Classification of childhood cancer based on tumor histology. (cdc.gov)
  • A classification system used by tumor or cancer registries to code the site and the histology of the cancer, usually from a pathology report. (cdc.gov)
  • The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)
  • The resulting aneuploidy is a key event in the progression of cancer and is correlated with tumor stage. (cdc.gov)
  • Environmental factors such as diet are thought to influence prostate cancer development and progression. (cdc.gov)
  • A potential mechanism for the role of calcium in prostate cancer development and progression is that intracellular calcium controls the growth of prostate cancer cells and the process of apoptosis (9). (cdc.gov)
  • Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
  • Several blood-based biosources and biomolecules, such as cell-free DNA and RNA, proteins, circulating tumor cells, and extracellular vesicles, have been explored for molecular test development. (prinsesmaximacentrum.nl)
  • Italian researchers say it's possible to monitor mesothelioma tumor progression with a simple blood test. (survivingmesothelioma.com)
  • Doctors have to carefully monitor mesothelioma tumor progression to tell if a treatment is working. (survivingmesothelioma.com)
  • One of the main ways to monitor mesothelioma tumor progression is by measuring the thickness of the pleura. (survivingmesothelioma.com)
  • Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma," Science Translational Medicine (2018). (medicalxpress.com)
  • Histological methods were employed to assess angiogenesis in tumor tissues. (researchsquare.com)
  • The results showed that tumor formation and growth were both significantly promoted by GEM or GEM+CDDP at as low as half of the metronomic dosages, which were accompanied by enhancements of angiogenesis in tumor tissues and the release of proangiogenic BMDCs in the circulating blood. (researchsquare.com)
  • These findings indicate that, the continuous low-dose administration of GEM and GEM+CDDP can promote tumorigenesis and tumor progression in vivo by inhibiting apoptosis, mobilizing BMDCs, and promoting angiogenesis in certain dose ranges. (researchsquare.com)
  • This study observes a previously neglected pharmacological phenomenon and investigates its mechanism of that the continuous low-dose administration of some antineoplastic agents in certain dose ranges can promote tumorigenesis and tumor progression in vitro and in vivo , through stimulation of tumor cell functions directly as well as enhancement of tumor angiogenesis by BMDCs recruitment indirectly. (researchsquare.com)
  • We established an important role of endothelial Pfn1 in tumor angiogenesis and further identified endothelial Pfn1-dependent regulation of several pro- ( VEGF , SERPINE1, CCL2) and anti-angiogenic factors ( platelet factor 4 ) in vivo. (bvsalud.org)
  • Conclusion: Phosphorylation of Tm1 at Ser283 contributes to its anti-tumor properties, and this effect results mainly from an increase in cell adhesion associated with a decrease in their migratory and invasive potentials. (scirp.org)
  • Our team has recently demonstrated a crucial new role for chaperone-mediated autophagy (CMA) in pericytes (PC)-acquired immunosuppressive function, which prevents anti-tumor immune responses and facilitates GB progression. (physiciansweekly.com)
  • Phagosome formation, cellular senescence, focal adhesion and the effector function to promote anti-tumor immune responses were the most affected pathways, revealing a transcriptomic profiling of specific target functions useful for future therapies. (physiciansweekly.com)
  • Bristol-Myers Squibb) would elicit anti-tumor activity against PCa and decrease immune suppressive features of the disease. (bmj.com)
  • Our results corroborate previous findings on the impaired immunogenic function of PC with GB-induced CMA, driving to other altered PC functions and the identifications of new target markers related to the tumor immune responses and useful for GB prognosis/therapy. (physiciansweekly.com)
  • The various tumor markers differ in their usefulness for screening, diagnosis, prognosis, assessing therapeutic response, and detecting recurrence. (medscape.com)
  • Tumour development, histology and grade of breast cancers: prognosis and progression. (who.int)
  • Pinealectomized rats showed higher mean number of tumor-associated macrophages and eosinophils in the invasive front of OSCC. (unesp.br)
  • In addition, the cytokine byproduct TGF-β activates macrophages to have an M2-like tumor-associated macrophage (TAM) phenotype. (nature.com)
  • Endothelial Pfn1 overexpression increases tumor infiltration by macrophages and concomitantly diminishes tumor infiltration by T cells including CD8+ T cells in vivo, correlating with the pattern of endothelial Pfn1-dependent changes in tumor abundance of several prominent immunomodulatory cytokines . (bvsalud.org)
  • Inflammation is known to promote both tumor development and progression. (cdc.gov)
  • Our study shows that a more effective strategy may be to inhibit specific tumor-promoting mechanisms attributed to PSCs, such as DKK3. (medicalxpress.com)
  • Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. (nottingham.ac.uk)
  • The lack of knowledge of the progression mechanisms of glioblastoma (GB), the most aggressive brain tumor, contributes to the absence of successful therapeutic strategies. (physiciansweekly.com)
  • In addition, several molecules associated with tumor mechanisms and related to tumor immune responses such as gelsolin, periostin, osteopontin, lumican and vitamin D, were identified in the PC secretome dependent on GB-induced CMA. (physiciansweekly.com)
  • We describe here long-term studies on the effects of androgen withdrawal on cloned androgen-responsive S115 mouse mammary tumor cells as a model system to investigate mechanisms by which tumor cells lose their steroid sensitivity. (rupress.org)
  • Although monoclonal in origin, mammary tumors acquire a marked heterogeneity of cell phenotypes, including a mixture of steroid hormone-sensitive cells and insensitive cells. (rupress.org)
  • Therefore, platelet aggregation may be a concomitant marker of tumor progression. (qxmd.com)
  • Mechanistic studies revealed that this progression was mediated by suppressed TNFα levels, both locally and systemically, resulting in reduced expression of tumor endothelial adhesion molecules, particularly intercellular adhesion molecule-1 (ICAM-1) and a subsequent decrease in the number of activated and effector CD8 + T cells in the tumor. (aacrjournals.org)
  • Tumor and endothelial cell functions, apoptosis, cell cycle analysis, as well as bone marrow derived cells (BMDCs) mobilization, were evaluated with transwell, MTT or flow cytometry analysis in vitro , respectively. (researchsquare.com)
  • We previously reported that Pfn1 is predominantly overexpressed in tumor -associated vascular endothelial cells in human clear cell renal carcinoma . (bvsalud.org)
  • Guided by Upstream Regulator Analysis of tumor transcriptome data, we further established endothelial Pfn1-induced Hif1α elevation and suppression of STAT1 activation. (bvsalud.org)
  • Hence, the adipocyte, as a major constituent of the mammary tumor stroma ( 3 ), is a likely contributor to tumor growth. (jci.org)
  • The answer may lie in treating a protein found in the scar-type tissue called stroma which often surrounds the tumors. (medicalxpress.com)
  • The tumor-associated stroma is comprised mostly of pancreatic stellate cells (PSCs) and its density and possibly the cells themselves are thought to prevent current treatments from effectively killing the tumor. (medicalxpress.com)
  • By 5 weeks of age, Brca1-KPC mice have adenocarcinoma with 100% penetrance, pSTAT3 in the tumor and stroma, high levels of MDSC, and increased plasma IL-6. (bmj.com)
  • Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)
  • In patients with metastatic renal cell carcinoma, neoadjuvant immunotherapy-based combinations yielded reductions in tumor size and pathologic necrosis at the time of cytoreductive nephrectomy. (cancernetwork.com)
  • They put ten men who had undergone a radical prostatectomy to remove their primary tumor, and then subsequently had increasing PSA levels, indicative of probable metastatic disease, on a whole food plant-based diet of whole grains, beans, seeds, and fruit. (naturallipomatreatment.com)
  • They are typically produced by tumor cells, but in some cases they may be produced by the body in response to malignancy or to certain benign conditions. (medscape.com)
  • For instance, tumor progression and malignancy is strongly dependent on tumor hypoxia. (lu.se)
  • The researchers say blood serum levels of the protein mesothelin correlate closely with tumor volume in malignant pleural mesothelioma patients. (survivingmesothelioma.com)
  • The aim was to determine whether EGFR protein expression contributes to the aggressiveness and recurrence potential of giant cell tumour of bone (GCTB), an osteolytic primary bone tumour that can exhibit markedly variable clinical behaviour. (ox.ac.uk)
  • In this respect, in contrast to predictors based for each serum protein was determined by comparing the samples upon tumor characteristics at the time of surgery, serum is a par- collected at the primary operation and then 3-6 mo later. (lu.se)
  • They identified regions of brain tumor progression by using this display application. (ajnr.org)
  • This phase is characterised by increased growth speed and invasiveness of the tumor cells. (wikipedia.org)
  • These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
  • Glioma is the most frequent primary central nerve tumor, which originates from glial progenitor cells [ 1 ]. (hindawi.com)
  • However, to the best of our knowledge whether frankincense, pine needle and geranium essential oils have any effect on the progression of BC in MCF-7 cells remains unclear. (spandidos-publications.com)
  • In conclusion, the present study indicated that frankincense, pine needle and geranium essential oils were involved in the progression of BC cells possibly through the AMPK/mTOR pathway. (spandidos-publications.com)
  • However, whether frankincense, pine needle and geranium essential oils have any effect on progression of BC in MCF-7 cells remains unclear. (spandidos-publications.com)
  • The CMA ablation in PC with GB cells showed an expected immunogenic phenotype able to phagocyte GB cells and a key strategy to develop future therapeutic strategies against GB tumor progression. (physiciansweekly.com)
  • Progression to steroid autonomy in S115 mouse mammary tumor cells: role of DNA methylation. (rupress.org)
  • In the prolonged absence of androgen, the cells lost hormone-sensitive parameters reproducibly, including loss of proliferative response, saturation density response, cell morphology response, and mouse mammary tumor virus long terminal repeat (MMTV-LTR)-related RNA. (rupress.org)
  • The possible role of de novo DNA methylation in the progression to androgen autonomy of S115 cells is discussed. (rupress.org)
  • TAMs are the major inflammatory cells in the TME, and are closely related to poor outcomes in several types of tumors [ 11 ]. (nature.com)
  • Additionally, GEM or GEM+CDDP at low concentrations dramatically facilitated the proliferation, migration, and invasion of tumor cells in vitro . (researchsquare.com)
  • We observed robust tumor growth in mice transplanted with LMS cell lines expressing TJP1 while no tumor mass was found in mice transplanted with SK-LMS-1 Sh-TJP1 cells with silenced TJP1 expression. (molcells.org)
  • These cells often form a tumor. (medlineplus.gov)
  • A malignant skin tumor composed of cells similar to those from the basal cell layer of the epidermis. (cdc.gov)
  • If a mesothelioma treatment is not having an impact on tumor growth, doctors need to know as soon as possible. (survivingmesothelioma.com)
  • The first step, termed the radial growth phase, is characterized by the net enlargement of the tumor at its periphery, along the radii of an imperfect circle. (nih.gov)
  • Tumors in this stage of development show a characteristic pattern of growth within the epidermis and a distinctive form of invasion of the papillary dermis. (nih.gov)
  • More importantly, we show that MESF treatment leads to significant inhibition of tumor growth and a 3-fold increase in the life span of tumor bearing animals compared to untreated tumor mice. (nature.com)
  • Due to DKK3's dual effects in promotion of tumor growth and in resistance to therapy, Hwang's results indicate that DKK3 is a therapeutic target as either monotherapy or in combination with immunotherapy or chemotherapy. (medicalxpress.com)
  • To evaluate the relevance of the Merlin-CD44 interaction in vivo, we compared tumor growth and progression in Cd44-positive and Cd44-negative Nf2-mutant mice. (uni-luebeck.de)
  • There are indications that certain antineoplastic agents at low dosages may exhibit abnormal pharmacological actions, such as promoting tumor growth. (researchsquare.com)
  • Therefore, a high calcium intake would counteract the potentially anticarcinogenic effects of vitamin D and thereby promote tumor growth. (cdc.gov)
  • Chaperone-Mediated Autophagy Ablation in Pericytes Reveals New Glioblastoma Prognostic Markers and Efficient Treatment Against Tumor Progression. (physiciansweekly.com)
  • Reciprocally, TGF-β from TAMs activated RAD18 in TNBC to enhance tumor stemness, forming a positive feedback loop. (nature.com)
  • In this situation, residual tumor is frequently nonviable. (medscape.com)
  • Tumor initiation Tumor promotion Compton C (2020). (wikipedia.org)
  • Many new tumor markers have been discovered since the development of monoclonal antibodies, and most tumor markers are now detected with them. (medscape.com)
  • As a result of the progression, phenotypical changes occur and the tumor becomes more aggressive and acquires greater malignant potential. (wikipedia.org)
  • So for many years, my lab has been focused on disparities, or looking at the biological contribution, or the tumor biology associated with why diseases so aggressive, particularly in African American men. (urotoday.com)
  • DNA global methylation studies indicate low methylation status in more aggressive tumors. (cdc.gov)
  • Molecular features of these tumors have expanded our vision of tumorigenesis and progression and provided abundant specifically targeted pathways [ 5 ]. (hindawi.com)
  • The purpose of this study was to compare traditional side-by-side and in-place (flicker) image presentation modes with advanced methods for detecting primary brain tumors on MR imaging. (ajnr.org)
  • Indicate the size of the primary tumor and how much it has spread into surrounding tissue. (medlineplus.gov)
  • before resection of the primary tumor and then postoperatively every 6-12 mo, resulting in three to five samples per patient. (lu.se)
  • Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. (nottingham.ac.uk)
  • The first randomized study in malignant pheochromocytoma and paraganglioma (MPP) has found that sunitinib prolongs progression-free survival (PFS) by more than five months. (news-medical.net)
  • In patient samples, we identified a transition from PGD 2 to PGE 2 -producing enzymes in the epithelium during the transition to PDAC, fibroblast/tumor expression of PTGIS, and myeloid/tumor cell expression of TBXAS1. (nih.gov)
  • How exactly does a normal cell become a tumour? (muhc.ca)
  • To study this molecular progression from normal to tumour, the researchers used CRISPR mutagenesis (genome editing) in cell culture, followed by next generation sequencing-based assays to study the genome, epigenome and transcriptome. (muhc.ca)
  • To assess this phenomenon, we established tumor myofibroblasts cell line and analyzed the up-regulating genes in myofibroblasts upon exposure with hypoxia and/or serum starvation. (nii.ac.jp)
  • A careful analysis of c-Met/RON expression or activity and a better elucidation of how they influence cell signaling will be useful in predicting which tumors respond best to these inhibitors as well as determining which agents can be used with these inhibitors for combined therapy. (oncotarget.com)
  • In the current study, we investigated the effects of pinealectomy on oral squamous cell carcinoma (OSCC) occurrence and progression in rats. (unesp.br)
  • Sometimes, tumor marker values may rise after effective treatment (due to cell lysis), but the increase may not portend treatment failure. (medscape.com)
  • Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
  • In these cases, the Italian researchers say blood testing for mesothelin is an effective alternative for tracking mesothelioma tumor progression. (survivingmesothelioma.com)
  • After adjusting for age and disease stage, the researchers found that mesothelin levels increased as pleural thickness increased, which correlated with mesothelioma tumor progression. (survivingmesothelioma.com)
  • The researchers concluded that a plant-based diet delivered in the context of stress management may slow the rate of tumor progression, and unlike other treatments, may give patients some control over their disease. (naturallipomatreatment.com)
  • Besides, administration of concentrated extracts of Morinda citrifolia in tumor containing animals increased the immune response of the animals with a concomitant reduction in tumor burden 7 . (nature.com)
  • At 5-6 weeks of age, mice (n = 5/group) were imaged by bioluminescent imaging (BLI) to confirm tumor burden and were then treated with vehicle or BMS-911543 by oral gavage daily for 14 days. (bmj.com)
  • A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. (nottingham.ac.uk)
  • However, more and more studies have confirmed that platelets also have an important relationship with tumor progression. (qxmd.com)
  • We recently discovered the potential of tumor-educated blood platelets (TEP) as a noninvasive biomarker trove for RNA biomarker panels. (prinsesmaximacentrum.nl)
  • A consistent increase in a tumor marker value, combined with lack of clinical improvement, may indicate treatment failure. (medscape.com)
  • This tumor can grow into the surrounding tissues and organs. (medlineplus.gov)
  • Early detection of tumors improves survival. (lu.se)
  • Commensal bacteria in the gastrointestinal tract are crucial to maintain immune homeostasis, and microbial imbalance or dysbiosis affects disease susceptibility and progression. (aacrjournals.org)