Tumor of mice. Medical search. Frequent questions

Such tumors tend to be more homogeneous than human cancers, she notes, and do "not always completely simulate the tumor microenvironment of human cancers. (the-scientist.com)
This observation suggests that the local tumor microenvironment provides cells and factors required for cancerous growth, which has not been reproduced in the laboratory. (rochester.edu)
Our long-term goal is to apply these studies toward the identification of unique cell subpopulations and factors in the local tumor microenvironment of lymphoid malignancies that will aid in the diagnosis and treatment of these cancers. (rochester.edu)
Additionally, we aim to advance a laboratory model of the local tumor microenvironment that will accelerate testing of therapeutic drug candidates to promote rapid clinical benefit for patients with lymphoid malignancies. (rochester.edu)
Computational modelling, based on these results, predicts that NMDA Rs in cancer cells could be strongly activated in the tumour microenvironment by both autocrine glutamate release and necrosis. (cam.ac.uk)
Analysis of immune biomarkers will focus on Jak2/STAT3 driven processes such as the percentage of MDSC, T cell subset analysis and inflammatory cytokines both systemically and in the tumor microenvironment. (bmj.com)
The tumor microenvironment (TM) in close contact with cancer cells is highly related to tumor growth and cancer metastasis. (peerj.com)
The healthy and HCC mice were used to isolate the PM, pre-tumor microenvironment (PTM), and TM. (peerj.com)
Malignant tumor, as a new "system" in the body, is gestated by the organic environment which is the time and space for a tumor system to survive and to proliferate, especially the microenvironment that is in close contact with cancer cells. (peerj.com)
The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice. (bvsalud.org)
RCQ increased the recruitment of T cells and reduced the accumulation of neutrophils and macrophages in the tumor microenvironment . (bvsalud.org)
RCQ reversed the predominance of immunosuppressive infiltrating cells in the tumor microenvironment and tipped the immune balance toward an immune activation state . (bvsalud.org)
In conclusion, RCQ can promote the ROS apoptosis mechanism of tumor cells and alleviate immunosuppression of the tumor microenvironment to enhance the anti- tumor effect. (bvsalud.org)

This retarded tumor growth, as the hypoxic/glycolytic tumor cells died from glucose starvation, and rendered the remaining cells sensitive to irradiation. (jci.org)

By contrast, oxygenated tumor cells have been thought to primarily use glucose for oxidative energy production. (jci.org)
Although lactate is generally considered a waste product, we now show that it is a prominent substrate that fuels the oxidative metabolism of oxygenated tumor cells. (jci.org)
A similar switch from lactate-fueled respiration to glycolysis by oxygenated tumor cells in both a mouse model of lung carcinoma and xenotransplanted human colorectal adenocarcinoma cells was observed after administration of CHC. (jci.org)

The majority of mammary tumors in mice are caused by mouse mammary tumor virus. (wikipedia.org)
the rest were females, almost all of them with benign mammary tumors. (rmca.org)
Mammary tumors can be quite squishy and flat, or they can feel firm, sometimes even as hard as cartilage. (rmca.org)
Benign mammary tumors are usually distinct lumps just under the skin that can be moved around slightly with the fingers. (rmca.org)
I've successfully removed mammary tumors the size of a small apple! (rmca.org)
Because mammary tumors are just under the skin the surgery to remove them is minor, as opposed to major surgery which enters a body cavity, and rats usually recover quite quickly. (rmca.org)
Although benign mammary tumors are most commonly seen in rats, they can also get a variety of other tumors. (rmca.org)
Although monoclonal in origin, mammary tumors acquire a marked heterogeneity of cell phenotypes, including a mixture of steroid hormone-sensitive cells and insensitive cells. (rupress.org)

Now, researchers from Washington University School of Medicine in St. Louis have identified an RNA molecule that suppresses prostate tumors in mice. (genengnews.com)
Here we show that a 'blocking' antibody to SPINK1 could slow the growth of prostate tumors in mice that were positive for the SPINK protein," says study author Arul Chinnaiyan, M.D., Ph.D., director of the Michigan Center for Translational Pathology and a Howard Hughes Medical Institute Investigator. (sciencedaily.com)

As MCT1 was found to be expressed by an array of primary human tumors, we suggest that MCT1 inhibition has clinical antitumor potential. (jci.org)
More importantly, we show that MESF treatment leads to significant inhibition of tumor growth and a 3-fold increase in the life span of tumor bearing animals compared to untreated tumor mice. (nature.com)
Using RNA-Seq, proteomics and phosphoproteomics we characterize NB cell and tumour responses to ATR inhibition, identifying key components of the DNA damage response as ATR targets in NB cells. (ugent.be)
ATR inhibition also produces robust responses in mouse models. (ugent.be)
Remarkably, a 2-week combined ATR/ALK inhibition protocol leads to complete tumor regression in two independent genetically modified mouse NB models. (ugent.be)
ATR inhibition enables complete tumour regression in ALK-driven NB mouse models," NATURE COMMUNICATIONS , vol. 12, no. 1, 2021. (ugent.be)
Many tumor cell lines and experimental tumors respond to HDAC inhibition. (aacrjournals.org)
TAK-285 was examined in a model of breast cancer brain metastasis using direct intracranial injection of BT-474-derived luciferase-expressing cells and showed greater inhibition of brain tumor growth compared to animals treated with lapatinib. (jcancer.org)

We report protease-resistant prion protein (PrP res ) in spontaneous lymphoreticular tumors of mice infected with the agent of variant Creutzfeldt-Jakob disease (vCJD). (cdc.gov)
The study revealed that "knockdown'" of a DNA-protein inhibitor, known as ID-2, in aggressive high-risk solid tumors resulted in activation of T-cells, which are white blood cells that have figured significantly in immunity research. (childrensnational.org)
As Children's researchers examined the impact of the knockdown of ID-2 protein on a tumor, they implanted N2a, a fast growing mouse neuroblastoma cell line, in the mice. (childrensnational.org)
mRNA expression levels of CXCL9, a chemokine recruiting CD8 + T cells, were lower in dLNs of STZ-mice than in normoglycemic mice after PD-1-Ab treatment, and its protein was expressed in DCs. (nature.com)
In the meantime, you can help your rat maintain her quality of life by making sure she eats a very nutritious diet, high in protein, carbohydrates, and vitamins, because the tumor will be drawing resources and energy from her body. (rmca.org)
Scientists gave cancerous lab mice a gene therapy that turned off the production of the Myc protein, which causes tumor growth. (medicaldaily.com)
To investigate the effects of necroptotic cells on tumors, doctoral student Annelise Snyder at the University of Washington along with her colleagues engineered cancer cells in which the RIPK3 protein-an enzyme that triggers the necroptotic pathway-was activated. (the-scientist.com)
These mice express a catalytically inactive fusion protein of the NH 2 -terminal part of HDAC2 and β-galactosidase, which fails to integrate into corepressor complexes with mSin3B. (aacrjournals.org)
The complexity and heterogeneity of the human plasma proteome have presented significant challenges in the identification of protein changes associated with tumor development. (nih.gov)
Here, we sought to exploit the merits of a well-characterized GEM model of pancreatic cancer to determine whether proteomics technologies allow identification of protein changes associated with tumor development and whether such changes are relevant to human pancreatic cancer. (nih.gov)
Analysis of proteins chosen on the basis of increased levels in plasma from tumor-bearing mice and corroborating protein or RNA expression in tissue documented concordance in the blood from 30 newly diagnosed patients with pancreatic cancer relative to 30 control specimens. (nih.gov)
The results demonstrate that the membrane-bound form of RANKL is sufficient for most functions of this protein but that the soluble form does contribute to physiological bone remodeling in adult mice. (cusabio.com)
Merlin is a versatile tumor suppressor protein encoded by the NF2 gene. (uni-luebeck.de)

There are two main types of tumors, benign and malignant. (rmca.org)
Although they can grow as fast as malignant tumors, they don't cause as much damage and they don't metastasize (spread to other parts of the body). (rmca.org)
In contrast, malignant tumors, also called cancer, usually invade and damage nearby tissues and also metastasize. (rmca.org)
In nine years I've done surgery on about 100 rats to remove tumors, and only a few have been malignant. (rmca.org)
If a tumor feels tightly attached to the underlying tissue, this can be a sign that it is malignant, but some benign tumors also feel attached. (rmca.org)
I have successfully removed two of these that I first suspected were malignant, so it's worth it to try to remove even tumors that appear to be attached. (rmca.org)
Researchers found these increased incidences of the kidney tumors in mice exposed to glyphosate worrisome because while adenomas are generally benign, they have the potential to become malignant, and even in noncancerous stages they have the potential to be harmful to other organs. (nationofchange.org)
Recently, isolated human lymphoid malignant cells have been successfully grown outside of the patient after transplant into immune deficient mice (a "xenograft", or cross-species transplant). (rochester.edu)
C: Tumor either Stage IA or Stage IB, but with tumor on the surface of one or both ovaries, or with capsule ruptured, or with ascites containing malignant cells or with positive peritoneal washings. (medscape.com)
A worldwide database analysis revealed that younger age, smaller tumor size, early stage, and granulosa cell tumor histologic type appear to be independent prognostic factors for improved survival in patients with malignant sex cord-stromal tumors who undergo lymph node dissection. (medscape.com)

When the mouse reaches puberty the virus begins to express its messenger RNA in the estrogen sensitive tissues. (wikipedia.org)
A and B ) MCT1 was detected by western blot ( A ) and confocal microscopy ( B ) in human tumor cell lines and control tissues. (jci.org)
The presence of infectivity and PrP res in inflamed liver, pancreas, and kidney tissues has been recently observed in transgenic and spontaneous mouse models of chronic inflammation on infection with the Rocky Mountain Laboratory strain of scrapie ( 6 ), and PrP res has been shown in mammary glands of scrapie-infected sheep with mastitis ( 7 ). (cdc.gov)
Brains and spleens were removed from all mice, and neoplastic tissues involving lymph nodes were removed from 4 infected and 1 uninfected mouse, and the thymus was removed from 2 infected mice ( Table ). (cdc.gov)
Benign tumors are almost always encapsulated in a membrane and separate from nearby tissues, and therefore easily removed by surgery. (rmca.org)
Because cancerous tumors intertwine with normal tissues, surgery is usually impossible in rats. (rmca.org)
Xenografts and liver organ tissues from OP449-treated mice demonstrated a 64% and 70% decrease in STAT5 activation, weighed against handles (p 0.01 and p=0.06, respectively). (findadig.com)
The analysis of the Hif1α pathway in SDHD-ESR tissues and in two newly derived cell lines after complete SdhD loss -a requirement for hereditary paraganglioma type-1 tumor formation in humans- partially recapitulated the "pseudo-hypoxic" response and rendered inconsistent results. (ed.ac.uk)
Only 3 benign breast tumour tissues (12.5%) and none of the healthy breast tissue specimens were HPV-DNA-positive. (who.int)
A further 20 blocks from The ISH results were given percentage vanced stages with a likely prevalence samples from normal breast tissues scores based on positive signals and of more aggressive tumour forms were labelled as a control group (i.e. number of cells that gave these signals. (who.int)

citation needed] The MMTV promoter is used in the PyMT model system of mouse models of breast cancer metastasis. (wikipedia.org)
Here we show that nicotine significantly promotes the progression and metastasis of tumors in mouse models of lung cancer. (nih.gov)
Nicotine also increased metastasis of dorsally implanted Line1 tumors to the lungs by 9 folds. (nih.gov)
We believe that exposure to nicotine either by tobacco smoke or nicotine supplements might facilitate increased tumor growth and metastasis. (nih.gov)
This study demonstrates for the first time that administration of nicotine either by i.p. injection or through over-the-counter dermal patches can promote tumor growth and metastasis in immunocompetent mice. (nih.gov)
These results suggest that while nicotine has only limited capacity to initiate tumor formation, it can facilitate the progression and metastasis of tumors pre-initiated by tobacco carcinogens. (nih.gov)
Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)
In anti-metastatic studies, lycopene has been found to inhibit the metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice ( 17 ). (frontiersin.org)
We hypothesized that disruption of the Merlin-CD44 complex through loss of Merlin, unleashes putative tumor- or metastasis-promoting functions of CD44. (uni-luebeck.de)
Importantly, while the absence of the Cd44 gene had no effect on the frequency of primary osteosarcoma development, it strongly diminished osteosarcoma metastasis formation in the Nf2-mutant mice. (uni-luebeck.de)
Among other putative functions of CD44, which may contribute to the metastatic behavior, the passage through the endothelial cells also appears to be critical in vivo, as CD44 significantly promoted formation of lung metastasis upon intravenous injection of osteosarcoma cells into immunocompromised mice. (uni-luebeck.de)

This means that in all the prostate cancer samples that we study, we rarely find NXTAR, because it is suppressed by the heavy presence of the androgen receptor in these types of tumors. (genengnews.com)

Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice xenografted with Lewis lung carcinoma (LLC) cells. (frontiersin.org)
The results showed that lycopene reduced the number of metastatic tumors in the lungs, which was further suppressed by the combined treatment with sorafenib. (frontiersin.org)
Tumor vascular leakiness and hypoxia were enhanced after HBOT, whereas histological characteristics, epithelial-to-mesenchymal transition markers, and metastatic incidence were not influenced. (eur.nl)
1992. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. (milkgenomics.org)
Heterozygous Nf2-mutant mice were prone to developing highly metastatic osteosarcomas. (uni-luebeck.de)

The researchers demonstrated restoring NXTAR expression caused the tumors to shrink using human prostate tumor samples implanted in mice. (genengnews.com)
In animal studies, we can often slow the growth of a tumor, shrink a tumor or prevent tumors from forming. (stanford.edu)
Reprogrammed skin cells shrink brain tumors in mice. (foundmyfitness.com)

Then centrifuge the cells and resuspend the human tumor mouse stromal cell pellet in five milliliters of PB buffer. (jove.com)
Sex cord-stromal tumors are groups of tumors composed of granulosa cells, theca cells, Sertoli cells, Leydig cells, and fibroblasts of stromal origin, singly or in various combinations. (medscape.com)
[ 1 ] sex cord-stromal tumors are classified into the following categories. (medscape.com)
Sex cord-stromal tumors account for approximately 8% of all ovarian tumors. (medscape.com)
Although various markers have been reported to stain sex cord-stromal tumors (eg, CD99, CD56, A103, müllerian inhibiting factor, vimentin), inhibin and calretinin have proven to be the most helpful to date. (medscape.com)
CD56 is a sensitive marker of ovarian sex cord-stromal tumors and may also be useful in the diagnosis of this group of neoplasms, especially in cases that are inhibin or calretinin negative, and the differential diagnosis includes neoplasms that are CD56 negative. (medscape.com)

Here, we have used low-noise whole-cell patch-clamp recording to investigate the electrophysiology of glutamate signalling in pancreatic neuroendocrine tumour (PanNET) cells derived from a genetically-engineered mouse model (GEMM) of PanNET, in which NMDAR signalling promotes cancer progression. (cam.ac.uk)

The administration of milk fermented by the probiotic Lactobacillus casei CRL 431 exerts an immunomodulatory effect against a breast tumour in a mouse model. (milkgenomics.org)

in an inhalation study and only equivocal evidence of metabolism to SO is below the limit of detection in nearly all samples, and the most active sample of lung lung tumors in two of four chronic toxicity/oncogenicity was approximately 100-fold less active than mouse studies by gavage in mice (reviewed in Cruzan et al . (cdc.gov)
Inhalation of iron-abundant gas metal arc welding-mild steel fume promotes lung tumors in mice. (cdc.gov)
It has been shown that exposure to GMAW-SS fume in A/J mice promotes lung tumors. (cdc.gov)
The objective was to determine if GMAW-MS fume, which lacks known carcinogenic metals, also promotes lung tumors in mice. (cdc.gov)
In conclusion, this study demonstrates that inhalation of GMAW-MS fume promotes lung tumors in vivo and aligns with epidemiologic evidence that shows MS welders, despite less exposure to carcinogenic metals, are at an increased risk for lung cancer. (cdc.gov)

Breast cancer is one of the most common primary tumors to develop associated brain metastases ( 1 , 2 ), and while recent progress in cancer therapy has improved control of primary breast tumors, methods to effectively treat brain metastases from breast cancer remain inadequate. (jcancer.org)

In a paper published July 8 in the journal Small, researchers at UCLA's California NanoSystems Institute and Jonsson Comprehensive Cancer Center demonstrate that mesoporous silica nanoparticles (MSNs), tiny particles with thousands of pores, can store and deliver chemotherapeutic drugs in vivo and effectively suppress tumors in mice. (uclahealth.org)
Human tumor xenografts are vascularized and infiltrated by cells of mouse origin during the growth phase in vivo . (jove.com)
These mice provide evidence that the key functions of HDAC2, although not essential for survival of the organism, play a rate-limiting role for tumor development in vivo . (aacrjournals.org)
To evaluate in vivo activity of BMS-911543, we used a genetically engineered PCa model with conditional expression of mutant KrasG12D, tp53R270H , and Brca1 alleles in pancreatic cancer cells (Brca1-KPC mice). (bmj.com)
To evaluate the relevance of the Merlin-CD44 interaction in vivo, we compared tumor growth and progression in Cd44-positive and Cd44-negative Nf2-mutant mice. (uni-luebeck.de)

In this study, we identified a long noncoding RNA (lncRNA), NXTAR (LOC105373241), that is located convergent with the AR gene and is repressed in human prostate tumors and cell lines. (genengnews.com)
The combination of selective gene knock-down in tumor cells and checkpoint blockade produced a novel, potent T-cell triggered tumor vaccine strategy," Dr. Sandler says. (childrensnational.org)
First, Yun and her colleagues generated a mouse model of early-stage colon cancer where APC gene is deleted. (medicalxpress.com)
The elimination of the contuminating mouse cells by this method allows the specific assessment of human tumor cell gene expression or in vitro direct responses. (jove.com)
To assess the role of an individual HDAC isoenzyme in physiology and tumor development, HDAC2-mutant mice were generated from a gene trap embryonic stem cell clone. (aacrjournals.org)
In this work, we made use of the inducible SDHD-ESR mouse, a conditional mutant in the SdhD gene, which encodes the small subunit of MCII, and that acts as a tumor suppressor gene in humans. (ed.ac.uk)

Augmented immunological activity as seen in increased NK and LAK activity by beta-glucan seems to play a role in preventing secondary infections associated with irradiation, and probably contributes to the attenuated tumor growth in tumor-bearing mice through enhanced anti-tumor immunity. (nih.gov)

However, some mice experienced dangerous levels of brain swelling, a side effect of the immune response triggered by the engineered cells, the researchers said, adding that extreme caution will be needed to introduce the approach in human clinical trials. (stanford.edu)
Washington, DC - A method to cure neuroblastoma tumors in mice has been discovered by Children's National researchers, opening the door for future clinical studies for a therapeutic patient-specific vaccine to cure one of the most common childhood cancers. (childrensnational.org)
The researchers also noted that a "massive influx" of T-cells infiltrated the shrinking tumor, indicating that T-cells are necessary for antitumor immunity in this vaccination protocol. (childrensnational.org)
Using mice, researchers first tested a monoclonal antibody -- a type of targeted treatment designed to go after a specific molecule (in this case, SPINK1). (sciencedaily.com)
The researchers suggest that the poor results may be because the treatment is appropriate only for patients with SPINK1-positive tumors. (sciencedaily.com)
The researchers also showed that MSNs accumulate almost exclusively in tumors after administration and that the nanoparticles are excreted from the body after they have delivered their chemotherapeutic drugs. (uclahealth.org)
In the study, researchers found that MSNs circulate in the bloodstream for extended periods of time and accumulate predominantly in tumors. (uclahealth.org)
The tumor accumulation could be further improved by attaching a targeting moiety to MSNs, the researchers said. (uclahealth.org)
Mice with breast cancer were used in this study, but the researchers have recently obtained similar results using mice with human pancreatic cancer. (uclahealth.org)
Now, researchers show that injecting cells undergoing necroptosis into mice's tumors directs killer T cells to attack the malignancies and slow their growth. (the-scientist.com)
But to the researchers' surprise, they witnessed the same slowdown of tumor growth when they instead injected necroptotic cells from a healthy fibroblast cell line into the tumors. (the-scientist.com)
For instance, when the researchers treated the necroptotic cells to curtail the production of those cytokines, and then injected them into tumors, they didn't see the slowdown in growth they had observed in earlier experiments. (the-scientist.com)
IMMUNE ASSISTANTS: Following radiation therapy, which triggers the release of cancer-specific antigens, researchers injected Salmonella typhimurium bacteria covered in positively charged nano-particles near tumors in mice. (the-scientist.com)
One weakness of the study, Anderson tells The Scientist , is that the researchers used transplanted tumors derived from a cell line in their mouse model. (the-scientist.com)
The answer seems to be 'Yes' at least in mice according to a study led by researchers at Baylor College of Medicine and Weill Cornell Medicine. (medicalxpress.com)
When the researchers provided the sugary drink in the water bottle for the APC-model mice to drink at their will, mice rapidly gained weight in a month. (medicalxpress.com)
To prevent the mice from being obese and mimic humans' daily consumption of one can of soda, the researchers gave the mice a moderate amount of sugary water orally with a special syringe once a day. (medicalxpress.com)
Jackson Laboratory Professor Carol Bult, Ph.D., leads a research program that develops and refines databases of genetic data that provide single sources of vital information about mouse genes, tumors, physical traits and other data for researchers around the globe. (jax.org)

Next, the team tested the GD2 CAR-T cells in mice whose brainstem was implanted with human DIPG tumors, an experimental system that Monje's lab pioneered. (stanford.edu)

The study is particularly significant because neuroblastoma , most commonly centered in the adrenal glands, is the third most common tumor in childhood, and the most common cancer in babies younger than one year old. (childrensnational.org)
The most common tumor in rats is a benign mammary tumor, with most of these being a fibroadenoma (Fibro-from connective tissue, aden-from a gland, oma-a benign tumor. (rmca.org)

MCT1 is expressed in a variety of different human tumor cell lines and primary human tumor biopsies. (jci.org)

This was accompanied by fewer tumor-infiltrating CD8 + T cells, and STZ-mice had fewer tumor-infiltrating CD11c + dendritic cells (DCs) than normoglycemic mice. (nature.com)
In this paper, we have developed a population semi-mechanistic model able to characterize the mechanisms implied in tumour growth dynamic after the administration of CyaA-E7, a vaccine able to target antigen to dendritic cells, thus triggering a potent immune response. (ebi.ac.uk)
The results suggest that the engineered Salmonella helped ensure that antigen-detecting dendritic cells , which immunosuppressive tumors can disable or keep at bay, came into contact with the tumor antigens and activated an immune response. (the-scientist.com)
The bacteria captured the negatively charged antigens and ferried them to dendritic cells in the tumors' periphery, where a tumor-targeting immune response was initiated, improving the animals' odds of survival. (the-scientist.com)

This glucocorticoid element is a promoter that is often used to construct mice which develop a breast cancer-like disease, because an animal model system for breast cancer close to the human disease is very much looked for. (wikipedia.org)
According to the research - conducted in mice implanted with human prostate tumor samples - restoring this so-called long noncoding RNA could be a new strategy to treat prostate cancer that has developed resistance to hormonal therapies. (genengnews.com)
Although many patients with prostate cancer are treated with therapies that block hormones that fuel tumor growth, most patients develop resistance to these therapies. (genengnews.com)
In mice, a fatal brainstem tumor was cleared by injecting it with engineered T cells that recognized the cancer and targeted it for destruction. (stanford.edu)
In mice whose brainstems were implanted with human DIPG, engineered immune cells known as chimeric antigen receptor T cells - or CAR-T cells - were able to eliminate tumors, leaving very few residual cancer cells. (stanford.edu)
When the brains of the mice were examined via immunostaining after treatment, the animals had, on average, a few dozen cancer cells left, compared with tens of thousands of cancer cells in animals that received a control treatment. (stanford.edu)
As a cancer immunotherapist, what gets me really excited is when you take an established tumor and you make it disappear," said Crystal Mackall , MD, professor of pediatrics and of medicine and the study's other senior author. (stanford.edu)
Scientists have known for decades that GD2 levels on some other forms of cancer are very high, but its discovery on this tumor came as a surprise, Mackall said, adding, "It was hiding in plain sight, and we didn't know. (stanford.edu)
The symptoms of cancer may include a skin ulcer, ulcerated tumor, or bleeding from a lump, a distended abdomen, weight loss, and lethargy. (rmca.org)
This week, tissue slides from long-dead mice in that long-ago research study are being scrutinized by fresh eyes as an expert pathologist employed by lawyers for cancer victims looks for evidence the lawyers hope will help prove a cover-up of the dangers of the weed killer called glyphosate. (nationofchange.org)
In recent years, biologists have begun to investigate whether activating necroptosis in cancer cells could similarly coax the immune system into attacking tumors. (the-scientist.com)
Importantly, these animals survived significantly longer than mice that had received injections of cancer cells that had apoptosis-inducing enzymes activated instead. (the-scientist.com)
That necroptotic cells don't have to carry any tumor antigen to have this effect was a remarkable finding to senior author Andrew Oberst , a cancer immunologist at the University of Washington. (the-scientist.com)
To him, it suggests that the necroptotic cells don't direct T cells to target tumors by displaying particular antigens, but rather by secreting particular cytokines and chemokines that activate local T cells that reside around the tumor and are already primed to attack those cancer cells, but need an external nudge to become active. (the-scientist.com)
Getting the body to attack cancer can be a challenge, as many tumors are able to suppress immune activity . (the-scientist.com)
Weitzenfeld and Fred Hutchinson Cancer Research Center's Kristin Anderson, who also didn't participate in the work, say they expect the treatment to work better in tumors with a high mutation rate. (the-scientist.com)
In humans, it usually takes 20 to 30 years for colorectal cancer to grow from early stage benign tumors to aggressive cancers. (medicalxpress.com)
Conclusions: Squamous cell carcinoma responds to HBOT with respect to tumor growth, vascular permeability, and hypoxia, which may have implications for its use in cancer patients. (eur.nl)
TAK-285 was as effective as lapatinib in antitumor activity in a mouse subcutaneous BT-474 breast cancer xenograft model. (jcancer.org)
Refined genetically engineered mouse (GEM) models of human cancer have been shown to faithfully recapitulate the molecular, biological, and clinical features of human disease. (nih.gov)
A similar thing happens with cancer cells, and they multiply and form tumors that remain undetected by the immune system. (milkgenomics.org)
In fact, some of the latest anti-cancer drugs target tumor blood supply to cut off the nutrient source required for all the energy needed for continued rapid growth (5). (milkgenomics.org)
Cancer biologists have developed many cancer cell lines in the laboratory, and have used these to study the characteristics of tumor growth and for development of new treatments. (milkgenomics.org)
The mouse mammary cancer cell line 4T-1 is one of these lines. (milkgenomics.org)
The skin cells were reprogrammed to form neural stem cells that deliver common cancer treatments to glioblastomas in mice. (foundmyfitness.com)
This study examined the effect on tumorigenesis and development of 4T1 breast cancer -bearing mice following administering RCQ by intragastric administration . (bvsalud.org)
The findings of cancer and other tumors in both rats and mice treated with propylene oxide meet the criteria established in the Occupational Safety and Health Administration (OSHA) Cancer Policy (3) for regarding it as a potential occupational carcinogen. (cdc.gov)
L'étude menée en Iraq a utilisé la méthode d'hybridation in situ pour déterminer la fréquence du papillomavirus humain et pour son génotypage dans les échantillons de tissus prélevés auprès de 129 patientes ayant reçu un diagnostic de cancer du sein malin, de 24 patientes porteuses d'une tumeur du sein bénigne et de 20 femmes témoins en bonne santé. (who.int)
In 1966, Dr. Lynch and colleagues described familial aggregation of colorectal cancer with stomach and endometrial tumors in two extended kindreds and named it cancer family syndrome. (medscape.com)

The treatment of mice with camptothecin-loaded MSNs led to shrinkage and regression of xenograft tumors. (uclahealth.org)
In mouse and rat xenograft tumor models, TAK-285 showed antitumor activity against cancers that expressed HER2 or EGFR. (jcancer.org)

Although benign tumors won't usually cause death directly, a tumor can grow so large that the rat has difficulty moving around and can't eat enough to support both the tumor and normal body functions. (rmca.org)
Fortunately, most tumors in rats are benign. (rmca.org)
If your rat gets one of these tumors, you can be 99% sure it's benign. (rmca.org)
If you're sure it's a benign tumor, you might be able to avoid an exam fee by calling different hospitals and asking how much they would charge for just the surgery to remove an adenoma from a rat. (rmca.org)
If you decide not to have a benign tumor removed, you can expect it to keep growing until it's almost as big as the rat herself. (rmca.org)

Bittner established the theory that a cancerous agent, or "milk factor", could be transmitted by cancerous mothers to young mice from a virus in their mother's milk. (wikipedia.org)

It is from these studies that novel techniques seen to reduce the size of prostate tumor xenografts have had recent success using drugs injected into mice (Greco et al. (experts.com)
We discovered that the amounts and weights of individual MDA-MB-231 breast cancers xenografts were better in hyperinsulinemic mice weighed against handles (p 0.05), and Rabbit Polyclonal to SirT1 IR phosphorylation was 4.5-fold higher in these mice (p 0.05). (findadig.com)
Right here we present results helping an anti-neoplastic aftereffect of OP449 on individual MDA-MB-231 breast cancers xenografts and murine MVT-1 tumors in the Rag /MKR immunodeficient mouse style of hyperinsulinemia (Zelenko, et al. (findadig.com)

show that Glu and Fru are directly absorbed by intestinal tumors, and daily dosing of SSBs accelerates tumor growth. (medicalxpress.com)

2001). No other tumor types were increased in these toxicity in mice and rats, including mouse lung tu- studies in mice. (cdc.gov)

Causes regression or oncolysis of various tumors (21). (cdc.gov)

Growing tumor models like those used in the study "can be great for asking proof-of-concept questions," Anderson says, but they sometimes make a poor proxy for human cancers, in which immune cells may lose functionality over time. (the-scientist.com)
Individual and murine breasts cancers tumors treated with OP449 had been 47% and 39% smaller sized than handles (p 0.05, for both, respectively). (findadig.com)
For shot of individual breast cancers cells, an immunodeficient MKR+/+ mouse was used. (findadig.com)
Tumor research MDA-MB-231 individual breast cancers cells had been received from ATCC, and cell series authentication. (findadig.com)

This study addresses the effects of two nutraceutical compounds on the expression of COX2 and tumor-associated inflammation in human papillomavirus type 16 (HPV16)-transgenic mice. (iiarjournals.org)
Results: Rutin reduced COX2 expression in the dermis (immunostaining score 7.83 versus 11.25 in untreated HPV16-transgenic mice) and epidermis (4.5 versus 10.0). (iiarjournals.org)

Besides, administration of concentrated extracts of Morinda citrifolia in tumor containing animals increased the immune response of the animals with a concomitant reduction in tumor burden 7 . (nature.com)
The research also focused on using "checkpoint blockade," a therapy in clinical use that allows for expansion of the immune response against tumors. (childrensnational.org)
The mathematical model developed presented the following main components: (1) tumour progression in the animals without treatment was described with a linear model, (2) vaccine effects were modelled assuming that vaccine triggers a non-instantaneous immune response inducing cell death. (ebi.ac.uk)
Measuring dendritic cell activation as a proxy for the anti-tumor immune response, they observed an 83 percent survival rate compared with just 25 percent in mice treated with radiotherapy and injected with saline. (the-scientist.com)
The authors concluded that the effect was due to restricted tumor blood supply as a result of modulation of the immune response and reduced inflammation. (milkgenomics.org)

Enhances action of carcinogens in mice (19). (cdc.gov)

Author information Abstract Immunotherapy is a growing therapeutic strategy in oncology based on the stimulation of innate and adaptive immune systems to induce the death of tumour cells. (ebi.ac.uk)

A February 1984 memo from EPA toxicologist William Dykstra stated the findings definitively: "Review of the mouse oncogenicity study indicates that glyphosate is oncogenic, producing renal tubule adenomas, a rare tumor, in a dose-related manner. (nationofchange.org)
Monsanto discounted the findings, arguing that the tumors were "unrelated to treatment" and showing false positives, and the company provided additional data to try to convince the EPA to discount the tumors. (nationofchange.org)

Engineered human immune cells can vanquish a deadly pediatric brain tumor in a mouse model, a study from the Stanford University School of Medicine has demonstrated. (stanford.edu)
These studies on transplanted tumors were extended to a mouse model where the tumors were induced by the tobacco carcinogen, NNK. (nih.gov)
To induce hyperglycemia, mice were intraperitoneally injected with STZ, which can damage pancreatic β cells resulting in the development of insulin dependent diabetes, a model of type 1 diabetes mellitus (T1DM). (nature.com)
Mathematical model approach to describe tumour response in mice after vaccine administration and its applicability to immune-stimulatory cytokine-based strategies. (ebi.ac.uk)
Using this mouse model of the disease, the team tested the effect of consuming sugar-sweetened water on tumor development. (medicalxpress.com)
After two months, the APC-model mice receiving sugary water did not become obese, but developed tumors that were larger and of higher-grade than those in model mice treated with regular water. (medicalxpress.com)
They discovered that the APC-model mice receiving modest high-fructose corn syrup had high amounts of fructose in their colons. (medicalxpress.com)
2010). Radiobiologists have valued this animal model for sustained grafted tumor growth, which permits fractionation considerations in therapeutic models, even for radiation therapy (Allam et al. (experts.com)
The hyperinsulinemic MKR mouse model continues to be previously defined (Ferguson, et al. (findadig.com)
We describe here long-term studies on the effects of androgen withdrawal on cloned androgen-responsive S115 mouse mammary tumor cells as a model system to investigate mechanisms by which tumor cells lose their steroid sensitivity. (rupress.org)
Mouse 4T1 breast tumor model. (milkgenomics.org)
Here, we investigated the impact of shortened telomeres in a mouse model for Barrett esophagus (L2-IL1B). (oncotarget.com)
The L2-IL1B mouse model is characterized by IL-1β-mediated inflammation, which leads to a Barrett-like metaplasia in the transition zone between the squamous forestomach and glandular cardia/stomach. (oncotarget.com)
In conclusion, our studies suggest that shortened telomeres are functionally important for tumor development in a mouse model of BE and are associated with proliferating columnar epithelium in human BE. (oncotarget.com)
The steady-state oxygen tension field of the tumor was calculated by iteratively employing Green's function method for diffusion and the Michaelis-Menten model for consumption. (lu.se)
For each oxygen distribution, the oxygen enhancement ratio (OER) was calculated and the mean absorbed dose at which the tumor control probability (TCP) was 0.99 (D(99)) was determined using the linear-quadratic cell survival model (LQ model). (lu.se)

The tumor testing (ie, immunohistochemistry, MSI, germline testing, and BRAF mutation testing), screening, and prophylactic surgery all help to reduce the risk of death in patients with HNPCC or Lynch syndrome. (medscape.com)

In the present study, Line1 mouse adenocarcinoma cells were implanted subcutaneously into syngenic BALB/c mice. (nih.gov)
She injected the cells into mouse melanoma or adenocarcinoma tumors the animals carried on their flanks. (the-scientist.com)
By 5 weeks of age, Brca1-KPC mice have adenocarcinoma with 100% penetrance, pSTAT3 in the tumor and stroma, high levels of MDSC, and increased plasma IL-6. (bmj.com)
Histologic analysis of pancreata from treated mice showed fewer foci of adenocarcinoma when compared to vehicle controls. (bmj.com)

Triggering necroptosis is considered an attractive strategy over inducing apoptosis because many tumors develop ways to block or evade apoptosis, he writes. (the-scientist.com)

We analyzed the effect of PD-1-Ab on tumor growth in streptozotocin-induced diabetic mice (STZ-mice) subcutaneously inoculated with MC38 (a colon carcinoma cell line). (nature.com)

Numerous studies have demonstrated marked differ- fects on terminal bronchioles are seen, but effects in ences in toxicity between rats and mice to styrene ex- the nasal olfactory epithelium do occur, although to posure, especially by inhalation. (cdc.gov)
Nasal tumors were induced in both rats and mice exposed to propylene oxide by inhalation. (cdc.gov)

Meanwhile, RCQ suppressed the development of tumor-infiltrating lymphocytes into immunosuppressive cell subpopulations, including CD4+ T cells to T helper Type 2 type (Th2), tumor -associated neutrophils (TANs) to the N2 TANs, and tumor-associated macrophages (TAMs) cells to M2 TAMs. (bvsalud.org)

Tumors treated with the SPINK1 antibody shrunk 60 percent, while tumors treated with cetuximab shrunk 40 percent. (sciencedaily.com)
however, it remains unknown whether the anti-tumor effects of anti-programmed cell death-1 antibody (PD-1-Ab) treatment are changed in hyperglycemic conditions. (nature.com)
To investigate the effect of hyperglycemia on anti-tumor function induced by anti-PD-1 antibody treatment, we treated STZ-induced diabetic mice with subcutaneous MC38 colon carcinoma tumors with anti-PD-1 antibody, and examined changes in tumor growth, the number of tumor-infiltrating immune cells, and the expression of chemokines and chemokine receptors. (nature.com)
Mice were intraperitoneally injected with STZ or sodium citrate buffer (CB) 7 days before subcutaneous inoculation with MC38 cells in the right flank on day 0 (Fig. 1 A). Then, the mice were treated with anti-PD-1 antibody or normal rat IgG on days 5, 8, and 11. (nature.com)
The effect of anti-PD-1 antibody on MC38 tumor is attenuated in STZ-induced diabetic mice. (nature.com)
The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Mouse TP53. (caslab.com)
Then a biotinylated detection antibody specific for Mouse TP53 and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. (caslab.com)
Only those wells that contain Mouse TP53, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. (caslab.com)
Furthermore, neither anti-mouse beta3 integrin function-blocking monoclonal antibody (mAb) nor alphav integrin function-blocking mAb inhibited sperm binding to or fusion with beta1 integrin null eggs. (lu.se)

Excess expression of the sugar is caused by the same mutation, known as the H3K27M mutation, that drives the growth of most DIPG tumors, the team found. (stanford.edu)

The tumor promotes the production of new blood vessels that become an integrated part of the tumor and keep the multiplying cells alive. (milkgenomics.org)

In the first experiment, the injected necroptotic cells were derived from the same cell line as the tumors, and carried the same cell surface antigens. (the-scientist.com)
Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice. (the-scientist.com)
The radiation triggered the tumors to shed negatively charged antigens that clung to the bacteria. (the-scientist.com)
As Anderson explains, "tumors that make a lot of proteins that look different from healthy proteins will likely result in more antigens for the bacteria to transport. (the-scientist.com)

Intraperitoneal injection of beta-glucan was shown to greatly delay mortality in mice exposed to whole-body X-ray radiation and tumor growth in tumor-bearing mice. (nih.gov)
Comparisons were made among four different types of radiation detectors, each inserted into the mouse phantom for radiation measurement under a 6 MV linear accelerator beam. (experts.com)
Xenografting is a common technique used by radiobiologists to test the characteristics of disease growth, inhibiting drugs, and tumor responses to drugs and radiation by the injection of tumors and drugs into nude mice. (experts.com)
Still, radiation control branches and inspectors general have provided approval for dual use with immunodepressed nude mice when infectious disease control measures are properly in place. (experts.com)
Purpose: Hyperbaric oxygen therapy (HBOT) is used in the treatment of radiation-induced tissue injury but its effect on (residual) tumor tissue is indistinct and therefore investigated in this study. (eur.nl)
The most pronounced radiation effect of increased pO(2) occurred with tumor tissue with 50% of the maximum vessel density used in the simulations. (lu.se)

A recent report by Aragon et al (2) reported that laboratory mice fed fermented milk had modulated immune responses and slowed tumor growth. (milkgenomics.org)

Eight members of the EPA's toxicology branch, including Lacayo and Dykstra, were worried enough by the kidney tumors in mice that they signed a consensus review of glyphosate in March 1985 stating they were classifying glyphosate as a Category C oncogen, a substance "possibly carcinogenic to humans. (nationofchange.org)
Unfortunately," Weitzenfeld cautions, "it is much easier to cure mice than humans. (the-scientist.com)
These results suggest that when the animals have early stage of tumors in the intestines-which can occur in many young adult humans by chance and without notice-consuming even modest amounts of high-fructose corn syrup in liquid form can boost tumor growth and progression independently of obesity," Yun said. (medicalxpress.com)
2003). These so-called nude mice have a marked ability to engraft many different types of tumor cells from other animals, including humans. (experts.com)
A panel of five proteins selected on the basis of their increased level at an early stage of tumor development in the mouse was tested in a blinded study in 26 humans from the CARET (Carotene and Retinol Efficacy Trial) cohort. (nih.gov)
100C (IARC, 2012 ) as carcinogenic and pentavalent methylated metab- male mice), and after weaning until to humans (Group 1). (who.int)
It is difficult to assess mice, which cannot repair certain In rodents, multiple studies showed the relevance to humans of rodent types of oxidative DNA damage, but that in utero exposure to arsenic via studies that use multiple agents, one not in Ogg+/+ mic e (IARC, 2012 ). (who.int)

Mouse tumors injected directly with the reprogrammed stem cells shrank 20- to 50-fold in 24-28 days compared with nontreated mice. (foundmyfitness.com)

Mice with visible tumors also had massive neoplastic nodular involvement of intestinal, mesenteric, cervical, and axillary lymph nodes and thymus. (cdc.gov)
Furthermore, we assessed the expression of chemokines by polymerase chain reaction (PCR) array in tumor-draining lymph nodes (dLNs) of these mice and MC38 cells cultured in different glucose concentrations. (nature.com)

Abstract -- In order to determine a mouse's dose accurately and prior to engaging in live mouse radiobiological research , a tissue-equivalent tumor-bearing phantom mouse was constructed and bored to accommodate detectors. (experts.com)
abstract = "To identify possible genetic interactions between themechanisms of tumor suppression of menin and pRb, weintercrossed mice with targeted deletions of Men1 andRb1, and compared tumor development in cohorts ofanimals carrying single or dual mutations of these tumorsuppressorgenes. (edu.au)

Conclusion: COX2 expression in HPV16-induced lesions may be modulated by nutraceuticals, reducing tumor-associated inflammation. (iiarjournals.org)
Here, we wanted to verify the extent of inflammation and oxidative stress in mice chronically-exposed to WPS and to evaluate, for the first time, its effect on alveolar injury and DNA damage and their association with impairment of lung function. (who.int)
CONCLUSION: We show the persistence of lung inflammation and oxidative stress in mice chronically-exposed to WPS and demonstrate, for the first time, the occurrence of DNA damage and enlargement of alveolar spaces and ducts associated with impairment of lung function. (who.int)

This type of mathematical approaches may be helpful to maximize the information obtained from experiments in mice, reducing the number of animals and the cost of developing new antitumor immunotherapies. (ebi.ac.uk)

Along with respiratory infections, tumors are one of the most common health problems and causes of death in rats, especially in females. (rmca.org)
Most rats are euthanized before reaching this stage, if the tumor isn't removed. (rmca.org)
I've also removed tumors from rats well over two years old, so age should not be the only factor when considering surgery. (rmca.org)
In Chico (a town of 70,000) some of the vets will remove tumors from rats for a reduced rate ($35 - 50) compared to the same surgery on a dog or cat ($150 - 200). (rmca.org)
in styrene metabolism between rats and mice. (cdc.gov)

Anatomy14

Organisms10

Diseases98

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes47

Disciplines and Occupations1

Information Science4

Health Care9

Microenvironment13

Retarded tumor growth1

Oxygenated tumor cells3

Mammary tumors8

Prostate Tumors in Mice2

Inhibition8

Protein13

Malignant10

Tissues10

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Types of tumors1

Metastatic5

Shrink3

Stromal6

Signalling in pancreatic1

Breast tumour1

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Researchers18

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Cancer29

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Xenografts3

Accelerates tumor1

20011

Regression1

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