Tumor nf e2 related factor 2. Medical search. Frequent questions

It is a potent inhibitor of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6(IL-6) release, and it in﫿uences mRNA expression of these cytokines in a dose- dependent manner. (perfumeworkshop.com)
Nitric oxide, prostaglandin E 2 , interleukin-1 beta, tumor necrosis factor alpha, and S100B levels were detected in plasma samples. (biomedcentral.com)
In vitro , wogonoside decreased the production of pro-inflammatory cytokines like Nitric oxide (NO), prostaglandin E2 (PGE 2 ), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6). (oncotarget.com)
[ 6 ] NF-KB protects cells from apoptosis in response to tumor necrosis factor-alpha (TNF-alpha). (medscape.com)

Cell viability, inflammatory cytokines levels (tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, and prostaglandin E2 (PGE2)), and related gene expression (TNF-α, IL-1β, IL-6, and cyclooxygenase-2 (COX-2)) were analyzed by ELISA and real-time PCR. (unimol.it)
Gigantol isolated from whole plants exhibits inhibitory effects of LPS-induced nitric oxide and prostaglandin E2 (PGE2) production in macrophages. (perfumeworkshop.com)
We found that OLE significantly suppressed the induction of pro-inflammatory mediators, tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, nitric oxide (NO), prostaglandin E2 (PGE2) and reactive oxygen species (ROS), while it enhanced the anti-inflammatory cytokine, IL-10. (unina.it)
In this research early‐passing RA‐SFB had been therefore weighed against OA‐SFB regarding the relative need for TNF‐R1/TNF‐R2 for TNFα‐induced signalling from the MAPK pathways proliferation secretion of IL6 IL8 prostaglandin E2 (PGE2) and matrix metalloproteinase‐1 (MMP‐1) aswell as the awareness of these features to inhibition of p38 ERK and JNK. (scienceexhibitions.org)
The production of several pro-inflammatory mediators, namely nitric oxide (NO) and prostaglandin (PG) E2 in RAW 264.7 murine macrophages, as well as tumor necrosis factor (TNF)-α and chemokine (C-C motif) ligand (CCL) 5 in human macrophages were inhibited by Cy extract (1.115 mg/mL). (uc.pt)

Via direct actions on cancer cells and indirect actions on the tumor microenvironment, radiation has the potential to enhance epithelial-to-mesenchymal transition, invasion, migration, angiogenesis and metastasis. (biomedcentral.com)
Effective hematopoiesis is facilitated by interactions of hematopoietic growth factors, various receptors, and the bone marrow microenvironment. (medilib.ir)
The consecutive stages of cancer growth and dissemination are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
Importantly, cell-associated and tumor microenvironment glycosaminoglycans (GAGs)/proteoglycan (PG) content and distribution are markedly altered during tumor pathogenesis and progression. (hindawi.com)
It is now increasingly recognized that the microenvironment plays a critical role in the progression of tumors. (hindawi.com)
The consecutive steps of tumor growth, local invasion, intravasation, extravasation, and invasion of anatomically distant sites are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
Cell-associated and tumor microenvironment GAG content and distribution is markedly altered during tumor pathogenesis and progression [ 11 , 12 ]. (hindawi.com)
In addition, obesity is associated with progression (but not incidence) of tumour microenvironment through prostate cancer. (who.int)

Functional studies in non-small cell lung cancer (NSCLC) patients revealed that hyperactivation of the NF-E2-related factor 2 (Nrf2) pathway facilitates tumor growth. (oncotarget.com)
Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF-кB pathway through microbiota-gut-brain axis - Phytother Res 2023 Apr 10 - 'Diabetic cognitive impairment (DCI) is a serious neurodegenerative disorder caused by diabetes, with chronic inflammation being a crucial factor in its pathogenesis. (qualitycounts.com)
Our results showed that quercetin post-treatment activated the Nrf2/HO-1 cascade, reversed pyroptosis, and modulated the autophagy-related pathway PDK/AKT/mTOR/P70S6/P6/eIF4E/4EBP1. (bvsalud.org)
Therefore, the effect of carnosol and an NF-B inhibitor BAY 11-7082 was examined, and the underlying role of the NF-B-dependent inflammatory pathway was analyzed as the target enzyme. (unimol.it)
Moreover, we demonstrated that OLE reduced the oxidative stress induced by palmitate in macrophages by regulating the NF-E2-related factor 2 (NRF2)−Kelch-like ECH-associated protein 1 (KEAP1) pathway. (unina.it)
From the literature review, the therapeutic targets of C. cassia extract and cinnamaldehyde, a compound of C. cassia, were found to be related with NFκB activity, and their signaling pathway were verified by experiments. (springeropen.com)
Recent advances in understanding the molecular events underlying hypohidrotic ectodermal dysplasia (HED) caused by mutations of the genes encoding proteins of the tumor necrosis factor α (TNFα)-related signaling pathway have been presented. (springer.com)
Novel data were reviewed and discussed on the structure and functions of the components of TNFα-related signaling pathway, the consequences of mutations of the genes encoding these proteins, and the prospect for further investigations, which might elucidate the origin of HED. (springer.com)
HED embraces a genetically heterogeneous group of diseases and is due to mutations of several genes that encode components of the tumor necrosis factor α (TNFα)-related signaling pathway (Cluzeau et al. (springer.com)
With the exception of EDA1 and NEMO , both localized on the X chromosome, all other genes encoding components of the TNFα-related signaling pathway involved in differentiation of skin appendages, are localized on the autosomes (Table 1 ). (springer.com)
Within the last 10 years significant progress has been made in understanding the pathogenesis of HED and this is mainly due to the discovery of unknown proteins and the elucidation of their function in signal transduction via the TNFα-related pathway. (springer.com)
The purpose of this report is to review current literature on the structure and function of components of the TNFα-related signaling pathway, to present a novel approach to their contribution in the differentiation of skin appendages and to discuss the role of mutations of genes encoding components of this pathway in the origin of HED. (springer.com)
The signaling via the TNFα-related pathway, which is critical for differentiation of skin appendages, has been elucidated mainly due to the investigations performed in mice (Mikkola 2009 ). (springer.com)
The downstream signal transduction toward Eda-A1 involves the canonical Wnt/β-catenin pathway (Clevers 2006 ) and requires lymphoid enhancer-binding factor-1 (Lef-1) for activation of the Ed1 ( Ta ) expression (Durmowicz et al. (springer.com)
Mechanistically, we found that wogonoside inhibited nuclear factor kappa B/ hypoxia-inducible factor two alpha (NF-κB/HIF-2α) activation via the phosphatidylinositol 3 kinase (PI3K) /AKT pathway. (oncotarget.com)
In conclusion, our stduy demonstrates that wogonoside attenuates IL-1β-induced ECM degradation and hypertrophy in mouse chondrocytes via suppressing the activation of NF-κB/HIF-2α by the PI3K/AKT pathway. (oncotarget.com)

Thus, HPK1 may function as a novel tumor suppressor and its loss plays a critical role in pancreatic cancer. (aacrjournals.org)
Among the tumor suppressor miRNAs, reduced let-7 expression occurs most frequently in cancer and typically correlates with poor prognosis. (encyclopedia.pub)
Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development. (uchicago.edu)

This suggests that autophagy is a form of adaptation of the nutritional environment of rapidly growing tumor cells in response to hypoxia. (spandidos-publications.com)

Data revealed that PAF and TF were partially responsible by Cy anti-inflammatory properties through the inhibition of NF-kB activation, NO production, the expression of inducible nitric oxide synthase (iNOS) and TNF-α. (uc.pt)
It also inhibited the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) both at gene and protein levels. (oncotarget.com)

PDT has been reported to be effective for treating aggressive colon cancer showing a high level of the vascular endothelial growth factor, which promotes tumor growth through angiogenesis ( 5 ). (spandidos-publications.com)
Elimination of the primary tumor, either by irradiation or by surgery, shifts the balance towards pro-angiogenesis and growth of the lung metastases (Table 1 ) (Camphausen et al. (biomedcentral.com)

MiRNA-9 levels were synergistically increased following IFNγ/LPS co-exposure in isolated macrophages and in vivo, in an IFN-γ/LPS-induced mouse model of steroid-resistant airway hyperresponsiveness (AHR) [ 2 ] . (encyclopedia.pub)
AntagomiRNA-mediated inhibition of miRNA-9 increased both PP2A activity and GR nuclear translocation in macrophages, and restored steroid sensitivity in isolated macrophages and in several mouse models of steroid-resistant AHR [ 2 ] . (encyclopedia.pub)

Further investigations showed that pterostilbene reduced the level of lipopolysaccharide, modulated colon and brain TLR4/NF-κB signaling pathways, and decreased the release of inflammatory factors, which in turn inhibited intestinal inflammation and neuroinflammation. (qualitycounts.com)
Additionally, ISO increased the levels of inflammatory markers (COX-2, NLRP3, and NF-ÐºB) and apoptotic mediators such as p-JNK. (bvsalud.org)
However, treatment with FA and FA-SLNs mitigated the severity of the ISO-induced response, and elevated the levels of antioxidant enzymes while downregulating inflammatory pathways, along with upregulation of the mitochondrial bioenergetic factor PPAR-Î³. (bvsalud.org)
Aldo-keto reductase family 1 member B10 (AKR1B10) is an inflammatory regulator and is closely related to the prognosis of patients with GC. (portlandpress.com)
Finally, we showed that OLE promoted the shift of M1 macrophage toward less inflammatory M2-cells via the modulation of the associated NF-κB and proliferator-activated receptor gamma (PPARγ) signaling pathways. (unina.it)
The usual treatment for acute gastritis following a long intake of non-steroidal anti-inflammatory drugs (NSAIDs) or alcohol is to stop the causal factors. (springeropen.com)
Objective To examine the relative need for tumour necrosis factor‐receptor 1 (TNF‐R1) and TNF‐R2 and their signalling pathways for pro‐inflammatory and pro‐harmful top TFR2 features of early‐passage synovial fibroblasts (SFB) from arthritis rheumatoid (RA) and osteoarthritis (OA). (scienceexhibitions.org)
These nutrients allow it to exhibit various physiological activities, such as anti-tumor and anti-inflammatory effects. (foodscience.news)
Traditional medicinal herbs have long been used as remedies against inflammatory-related diseases. (uc.pt)
Its anti-inflammatory activity was correlated with the inhibition of p38 mitogen-activated protein kinase (MAPK) and c-jun NH2-terminal kinase (JNK) 1/2 signaling pathways. (uc.pt)
Moreover, it was verified, for the first time, that Cy extract inhibited the chymotrypsin-like activity of proteasome, with the consequent inhibition of the nuclear factor (NF)-kB, a transcription factor that regulates the expression of numerous inflammatory mediators. (uc.pt)
The pro-inflammatory miRNA-9 was found to be increased in sputum samples from patients with neutrophilic asthma, which is often resistant to corticosteroid therapy, compared with eosinophilic asthma [ 2 ] . (encyclopedia.pub)
NF-KB is important in immune, inflammatory, and apoptotic pathways. (medscape.com)

Wogonoside also inhibited hypertrophy and the generation of vascular endothelial growth factor (VEGF) in interleukin-1β (IL-1β)-induced chondrocytes. (oncotarget.com)

Hypoxia stimulates hypoxia inducible factor (HIF)-dependent expression of CXCL12 and KITL promoting mobilization from the bone marrow and recruitment to primary tumor and metastatic sites of CXCR4 + CD11b + bone marrow-derived cells and KITbCD11b + cells assisting vasculogenesis and metastasis respectively (Kuonen et al. (biomedcentral.com)

6-Shogaol, an active constituent of ginger, is a potent inhibitor of MDA-MB-231 cell invasion, and the molecular mechanism involves at least in part the down-regulation of MMP-9 transcription by targeting the NF-κB activation cascade, thus has potential for clinical use as antimetastatic treatments. (syntides.com)

Yet, far less attention is paid to the effects of these treatments on tumor progression as reflected by the metastatic process. (biomedcentral.com)

Thus, GAGs/PGs may modulate downstream signaling of key cellular mediators including insulin growth factor receptor (IGFR), epidermal growth factor receptor (EGFR), estrogen receptors (ERs), or Wnt members. (hindawi.com)

Such treatment was associated with upregulation of invasion- and inflammation-promoting soluble factors, such as matrix metalloproteinase 2 (MMP2), its activator MMP14, tissue inhibitors of matrix metalloproteinase 2 (TIMP2), chemokine ligand 2 (CCL2), and urokinase-type plasminogen activator (uPA), the latter two being linked to the recruitment of the monocytic cells. (biomedcentral.com)

Nrf2 expression positively correlated with lymph node metastasis ( P = 0.001) and negatively correlated with tumor differentiation ( P = 0.032). (oncotarget.com)
Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells. (uchicago.edu)
Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. (uchicago.edu)
Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation. (uchicago.edu)

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. (wikipedia.org)
These effects are produced through its ability to block nuclear factor kappa B (NF-kappaB) activation. (perfumeworkshop.com)
ED1 , encoding a ligand-ectodysplasinA-A1 (EDA-A1), EDAR , coding for ectodysplasinA-A1 receptor, EDARADD , programming the structure of EDAR-associated death domain protein and NEMO whose protein product, NFκB essential modulator (NEMO), is necessary for an indirect activation of nuclear factor κB (NFκB). (springer.com)
In 2000, the International Incontinentia Pigmenti Consortium reported that incontinentia pigmenti is caused by a genomic rearrangement of the gene for NEMO, or nuclear factor kappa B essential modulator (IKBKG-IKK gamma). (medscape.com)
Activation of the transcription factor nuclear factor KB (NF-KB) requires the NEMO protein. (medscape.com)

Local invasion and distant metastasis are the cause of death in most malignant tumors. (biomedcentral.com)
Malignant tumors consist of cancer cells and tumor-associated host cells, both participating in invasion and distant metastasis. (biomedcentral.com)
One of the first molecules implicated in enhancement of distant metastasis after irradiation of the primary tumor was angiostatin, produced by the primary tumor and keeping metastasis dormant. (biomedcentral.com)

Irradiated Ce6 produced singlet oxygen which rapidly induces tumor cell death. (spandidos-publications.com)

NRF2 is a basic leucine zipper (bZip) transcription factor with a Cap "n" Collar (CNC) structure. (wikipedia.org)
OBJECTIVE- Sulforaphane is an activator of transcription factor NF-E2-related factor-2 (nrf2) that regulates gene expression through the promoter antioxidant response element (ARE). (diabetesjournals.org)
This also abolished the counteracting effect of sulforaphane, suggesting mediation by nrf2 and related increase of transketolase expression. (diabetesjournals.org)
CONCLUSIONS- We conclude that activation of nrf2 may prevent biochemical dysfunction and related functional responses of endothelial cells induced by hyperglycemia in which increased expression of transketolase has a pivotal role. (diabetesjournals.org)
Levels of Nrf2 and NQO1 were elevated in tumor tissues. (oncotarget.com)
In particular, Nrf2 was elevated in nearly all tumor cells. (oncotarget.com)
NF-E2-related factor 2 (Nrf2) is a member of the Cap'n'Collar/basic leucine zipper (CNC-bZIP) transcription factor family. (oncotarget.com)

RNA interference-mediated gene silencing of vascular endothelial growth factor in colon cancer cells. (uchicago.edu)

Specifically, these extracellular matrix (ECM) components critically modulate the tumor cell "motile phenotype" affecting their adhesive/migratory abilities which are directly correlated to the metastatic cascade [ 5 , 6 ]. (hindawi.com)
The MONW phenotype is related to the intake of unbalanced diets, such as those rich in fat. (biomedcentral.com)

Sustained Lower Incidence of Diabetes-related End-stage Kidney Disease among American Indians and Alaska Natives, Blacks, and Hispanics in the United States, 2000-2016. (cdc.gov)

2011. NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). . (oregonstate.edu)
2013. Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. . (oregonstate.edu)
2012. MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. . (oregonstate.edu)

Concurrently, p62 gene expression is increased by oxidative stress through activation of the transcription factor NF-E2-related factor 2 ( 18 ). (spandidos-publications.com)
It also inhibits in﫿ammatory and allergic response in mast cells, and ultraviolet beam-induced skin in﫿ammation by reducing cyclooxidagenase-2-expression and NF-kappa B nuclear localization. (perfumeworkshop.com)
The expression of regulatory molecules, TGF-β1/2, phospho-Akt (Ser473), PPARα, sterol regulatory element-binding protein 1 (SREBP-1), fatty acid synthase (FASN), hormone-sensitive lipase (HSL), and acyl dehydrogenases was analyzed in virus-infected hepatocytes. (academic-accelerator.com)
CTE also upregulated the nuclear translocation of NF-E2-related factor 2 (Nfr2) and its target gene expression. (foodscience.news)
Piceatannol inhibits phorbol ester-induced NF-κB activation and COX-2 expression in cultured human mammary epithelial cells. (snu.ac.kr)
Moreover, wogonoside promoted the expression of anabolic factors Sox-9, type two collagen and aggrecan while inhibiting the expression of catabolic factors such as matrix metalloproteinases (MMPs) and thrombospondin motifs 5 (ADAMTS-5) in mouse chondrocytes. (oncotarget.com)
Expression analysis of cognitive decline-related genes was performed using RT-qPCR, and working memory was assessed using a T-maze. (biomedcentral.com)
The expression of Recombinant adenovirus IkappaBalphaM in human hepatocarcinoma HepG2 and it's inhibitive effect to the activity of NF-kappaB]. (uchicago.edu)

Despite substantial improvements in diagnosis and treatment, the prognosis of GC patients is still poor [ 2 ]. (portlandpress.com)

A recent study showed that the hypoxic environment produced by PDT can induce autophagy in tumor cells ( 17 ). (spandidos-publications.com)

Breast cancer remains a very common disease among women, with an annual global incidence of over 2 million cases per year and one of the highest numbers of cancer- related deaths among women (1, 2). (vitamindwiki.com)

In the skin, NF-KB regulates cell growth in the stratified epithelium and apoptosis. (medscape.com)

Colorectal cancer is the third most commonly diagnosed cancer and fourth leading cause of cancer-related deaths ( 1 ). (spandidos-publications.com)
To treat patients with colorectal cancer, an approach that selectively targets cancer cells without damaging normal cells and which minimizes the risk of perforating the intestinal barrier is needed ( 2 ). (spandidos-publications.com)
PDT is considered as a complementary therapy aimed at preventing tumor recurrence after surgical resection of colorectal cancer ( 3 ), making it a suitable approach for continuous removal of small fractions of tumors ( 4 ). (spandidos-publications.com)
In the general population, the risk of developing colorectal cancer is approximately 19 percent, and it is estimated that 2 percent to 5 percent of sporadic polyps will develop into an invasive cancer (Markowitz AJ et al 1997). (bioresonancetherapy.com.sg)

Metastatic cancer cells are released from the primary tumor or from other metastases, at an undefined moment of its development, to arrive in the circulation and home at distant sites, where the ecosystem permits them to survive and either remain dormant as micro-metastases or grow to form macro-metastases (Mareel et al. (biomedcentral.com)
2001 ). Molecular communication between ecosystems is also witnessed by the vasculogenic and pro-metastatic tumor bed effect as discussed by Kuonen et al. (biomedcentral.com)

Immune tolerance co-evolved as a safety system that maintains a state of immune unresponsiveness to autoantigens and self-tissues ( 2 , 3 ). (frontiersin.org)
Evidence suggest that a patient's genetic predisposition together with environmental factors, such as exposure to pathogens that exhibit molecular mimicry, disturb immune tolerance ( 4 ). (frontiersin.org)
Results: Macrophage polarization was the main immune infiltration pattern in GC, and the state of macrophage polarization was closely related to the pathological grading of GC and the clinical stage of patients. (portlandpress.com)
LIGHT delivery to tumors by mesenchymal stem cells mobilizes an effective antitumor immune response. (uchicago.edu)

The Part 2 post in this series is concerned with mainline anti-cancer drug interventions that simultaneously address multiple growth pathways, ones that are entering clinical practice. (anti-agingfirewalls.com)
The Part 1 and Part 2 posts are about hot areas of intensive research as well as practical clinical experimentation. (anti-agingfirewalls.com)
The clinical picture of TGR caused by either pathogen is similar: fever, headache, and exanthema ( 1 , 2 ). (cdc.gov)

Obesity-related cancers. (who.int)

2017. Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. . (oregonstate.edu)

2020 Feb 1;174(2):e194498. (cdc.gov)
Screening for SARS-CoV-2 Infection Within a Psychiatric Hospital and Considerations for Limiting Transmission Within Residential Psychiatric Facilities - Wyoming, 2020. (cdc.gov)
2020 Dec;8(2):e001917. (cdc.gov)

Tumor and adjacent non-tumor tissue samples were collected from 215 NSCLC patients who had tumor resections between 2006 and 2011. (oncotarget.com)
Relating in vitro to in vivo exposures with physiologically-based tissue dosimetry and tissue response models. (cdc.gov)
In 1900, noted French physicians Klippel and Trenaunay first described a syndrome in 2 patients presenting with a port-wine stain and varicosities of an extremity associated with hypertrophy of the affected limb's bony and soft tissue. (medscape.com)

Overexpression of p62 is likely related to tumorigenesis and has been observed in many types of tumors ( 13 , 21 - 23 ), such as chemotherapy-resistant epithelial cell carcinoma ( 24 ). (spandidos-publications.com)

Autophagy contributes to the prolonged survival of tumor cells, whereas defects in autophagy play a critical role in tumorigenesis ( 15 , 16 ). (spandidos-publications.com)
[ 1 , 3 ] A statistically significant improvement in overall survival (OS) and an increase in the rate of tumor shrinkage was shown in women treated with bevacizumab plus chemotherapy compared with chemotherapy alone. (medscape.com)

In addition, docking studies analyzed carnosol's molecular interactions and binding modes to NF-B and IKK. (unimol.it)

An inhibitory molecule of the IKB family interacts with NF-KB to sequester it in the cytoplasm. (medscape.com)

NFE2L2 and other genes, such as NFE2, NFE2L1 and NFE2L3, encode basic leucine zipper (bZIP) transcription factors. (wikipedia.org)

There is good evidence that cancer cells disseminate from the primary site early during tumor development (Hosseini et al. (biomedcentral.com)
Such cells are described as disseminated tumor cells (DTC) (Sosa et al. (biomedcentral.com)
2014 ) or sometimes as circulating tumor cells (CTC) (Kim et al. (biomedcentral.com)
Third, IL-2 therapies aiming at expanding immunosuppressive regulatory T cells in vivo . (frontiersin.org)
Thus, during normal hematopoiesis, there exists a cellular hierarchy headed by a stable population of pluripotent stem cells that generate lineage-specific progenitors, which differentiate into the various types of mature blood cells [ 2 ]. (medilib.ir)
Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells. (uchicago.edu)

2006. Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status. . (oregonstate.edu)

Transient overexpression of UBCv1 impaired activation of NF-κB and AP-1 transcription factors induced by several agonists of these pathways. (mdpi.com)

Furthermore, our in silico analyses also supported the modulation of NF-B and IKK by carnosol. (unimol.it)

Co-sensitization involving Ni and the other 2 precious metals is frequent even though the expertise on a possible immunological cross-reactivity using within vivo and in vitro approaches is still restricted. (pafrinhibitors.com)
This article summarizes recent advances in in vitro and in vivo research on the anti-cancer effects and related mechanisms of some promising natural products. (anti-agingfirewalls.com)

However, the molecular mechanism in preventing obesity-related inflammation has not been elucidated. (unina.it)

Metabolically-obese, normal-weight (MONW) individuals are not obese in terms of weight and height but have a number of obesity-related features (e.g. greater visceral adiposity, insulin resistance, and increased risk of cardiovascular disease). (biomedcentral.com)

Some authors suggest that there is a transition phase referred to as mild cognitive impairment (MCI) in which individuals do not yet meet the criteria for dementia, but are at a greater risk of developing it [ 2 , 3 ]. (biomedcentral.com)

Phytochemistry: It has 5,7-dihydroxy-3-(3-hydroxy- 4-methioxybenzyl)-6-methoxychroman-4-one is the homoiso﫿avanone that inhibits basic 﫿broblast growth factor. (perfumeworkshop.com)

Cardiac, pulmonary, and central nervous system (CNS) complications can occur during the course of infection ( 1 , 2 ). (cdc.gov)
Fatality rates among patients with untreated typhus are ≈4% ( 3 , 4 ) among patients with R. typhi infection and 13%-30% ( 2 ) among those with R. prowazekii infection. (cdc.gov)
BACKGROUND: Protection against symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019 [COVID-19]) can limit transmission and the risk of post-COVID conditions, and is particularly important among healthcare personnel. (cdc.gov)
OBJECTIVE: To characterize residential social vulnerability among healthcare personnel (HCP) and evaluate its association with severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection. (cdc.gov)

Anatomy13

Organisms8

Diseases69

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes51

Disciplines and Occupations1

Information Science6

Health Care13

Geographicals2

Necrosis factor-alpha4

Prostaglandin5

Microenvironment8

Pathway16

Suppressor3

Growing tumor cells1

Nitric2

Angiogenesis2

Macrophages2

Inflammatory13

Interleukin1

Hypoxia induci1

Inhibitor1

Progression1

Mediators1

Matrix metalloproteinase1

Differentiation4

Nuclear factor5

Metastasis3

Induces1

NRF27

Vascular endoth1

Phenotype2

20161

Colon3

Expression8

Prognosis1

Hypoxic1

Incidence1

Regulates1

Colorectal cancer4

Metastatic2

Immune4

Clinical3

Cancers1

Viability1

20203

Tissue3

Epithelial cell1

Survival2

Interactions1

Inhibitory1

Basic leucine zipper1

Cells6

Beta-catenin1

Activation1

Modulation1

Vitro2

Inflammation1

Obesity-related1

Cognitive1

Growth factor1

Infection4