Tumor Necrosis Factor-alphaReceptors, Tumor Necrosis FactorAntirheumatic AgentsAntibodies, MonoclonalReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIInterleukin-1CytokinesGroup IV Phospholipases A2LipopolysaccharidesInterleukin-6Cells, CulturedNecrosisNF-kappa BRNA, MessengerInterferon-gammaSignal TransductionArthritis, RheumatoidMacrophagesMitogen-Activated Protein Kinase 14Lymphotoxin-alphaMice, Inbred C57BLCell LineHypoxia-Inducible Factor 1, alpha SubunitMonocytesRecombinant ProteinsApoptosisInflammationMice, Inbred BALB CGene Expression RegulationTumor Necrosis FactorsTransforming Growth Factor alphaEnzyme InhibitorsInterleukin-10Gene ExpressionInterleukin-8Immunoglobulin GDose-Response Relationship, DrugTumor Necrosis Factor Decoy ReceptorsMolecular Sequence DataMice, KnockoutAntigens, CDMacrophage ActivationBase SequenceSynovial MembraneDisease Models, AnimalReverse Transcriptase Polymerase Chain ReactionTime FactorsCell Line, TumorUp-RegulationLeukocytes, MononuclearInterleukin-1betaEnzyme-Linked Immunosorbent AssayTumor Cells, CulturedTransfectionMembrane GlycoproteinsNeutrophilsInflammation MediatorsEndotoxinsMacrophages, PeritonealFlow CytometryDrug SynergismCell SurvivalI-kappa B ProteinsT-LymphocytesFibroblastsBlotting, WesternDown-RegulationCell DivisionAnti-Inflammatory AgentsPentoxifyllineImmunohistochemistryPromoter Regions, GeneticEnzyme ActivationTranscription, GeneticI-kappa B KinaseTNF Receptor-Associated Factor 2Mice, Inbred C3HTreatment OutcomeInterleukin-12Nitric OxideEndothelium, VascularTranscription Factor RelALiverIntercellular Adhesion Molecule-1Granulocyte-Macrophage Colony-Stimulating FactorTumor Markers, BiologicalReceptors, Cell SurfaceKineticsPhosphorylationTumor Necrosis Factor Receptor-Associated Peptides and ProteinsLungAntigens, CD14TNF-Related Apoptosis-Inducing LigandInterleukinsSpleenShock, SepticPolymerase Chain ReactionAntibodiesp38 Mitogen-Activated Protein Kinases