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  • expression
  • Together, the results of the present study are the first to demonstrate that endogenous TNF-alpha is required in vivo for the expression of macrophage activation with respect to the release of reactive nitrogen intermediates and toxoplasmastatic activity and for enhanced listericidal activity in the livers and spleens of mice stimulated with rIFN-gamma. (mysciencework.com)
  • activation
  • The aim of the present study was to determine whether endogenously formed TNF-alpha also is required for rIFN-gamma-induced macrophage activation and enhanced antimicrobial activity in vivo. (mysciencework.com)
  • proliferation
  • Intravenous injection of a large dose of rTNF-alpha resulted in a decrease in the number of bacteria in the liver and spleen, but an injection of rIFN-gamma and rTNF-alpha did not result in enhanced inhibition of the proliferation of L. monocytogenes. (mysciencework.com)
  • protein
  • TNF-alpha protein concentrations in plasma and in conditioned medium of explanted adipose tissue were measured by ELISA. (jci.org)
  • Similar increases were also observed in adipose production of TNF-alpha protein but circulating TNF-alpha levels were extremely low or undetectable. (jci.org)
  • OBJECTIVES: To examine the effect of tumor necrosis factor-alpha (TNF-alpha) on pulmonary artery pressure and on total protein, phospholipid, lysophosphatidylcholine, phosphatidylcholine, phosphatidylinositol, and phosphatidylglycerol content in the bronchoalveolar lavage-accessible space of the isolated perfused rat lung, and to evaluate the role of the lung in the clearance of TNF-alpha from the perfusion medium in this model. (biomedsearch.com)
  • potent
  • These results demonstrate that low concentration BV possess a potent suppressive effect on anti-apoptotic responses of TNF-alpha/Act D-treated hepatocytes and suggest that these compounds may contribute substantial therapeutic potential for the treatment of liver diseases. (unboundmedicine.com)
  • hypothesis
  • We demonstrate that, contrary to this hypothesis, phosphorylation of I kappa B alpha induced by tumor necrosis factor alpha in HeLa cells does not induce dissociation. (pnas.org)
  • Our findings support the hypothesis that TNF-alpha may alter surfactant composition, which may in turn contribute to the development of the adult respiratory distress syndrome. (biomedsearch.com)
  • treatment
  • Our results showed statistically significant inhibition in DNA damage caused by BV treatment compared to corresponding TNF-alpha/Act D-treated hepatocytes. (unboundmedicine.com)
  • Treatment of rheumatoid arthritis (RA) with anti-TNF-alpha antibody (Remicade). (nih.gov)
  • supernatants
  • Decreased IL-1alpha and TNF-alpha production in 24-hr culture supernatants of mononuclear cells isolated from liver perfusate was detected while IL-6 remained unchanged over 20 weeks. (nih.gov)
  • T cells and Kupffer cells were the major source of TNF-alpha in culture supernatants of hepatic perfusate mononuclear cells from ethanol-consuming rats injected LPS. (nih.gov)
  • liver
  • The relationship between the changes in liver pathology and the production of interleukin (IL)-1alpha, IL-6, and tumor necrosis factor-alpha (TNF-alpha) by intrahepatic mononuclear cells was studied in rats fed alcohol and subsequently exposed to lipopolysaccharide (LPS). (nih.gov)
  • In addition, pathological liver injury was evident, which suggests a pathogenic role for TNF-alpha in alcohol-induced liver disease. (nih.gov)
  • vivo
  • b) Increases in pulmonary arterial pressures seen in vivo with TNF-alpha administration are not due to a direct effect. (biomedsearch.com)
  • serum
  • We performed a systematic review and meta-analysis to determine whether maternal serum concentration of tumor necrosis factor-alpha (TNF- α ), leptin, and adiponectin were associated with GDM. (hindawi.com)
  • Cultured HPDL cells were treated with TNF-alpha in serum-free condition. (nih.gov)
  • phosphatidylinositol
  • 02). CONCLUSIONS: a) TNF-alpha alters the amounts of phosphatidylcholine, phosphatidylinositol, and possibly phosphatidylglycerol present in the lavage-accessible space of the isolated perfused rat lung. (biomedsearch.com)
  • The upregulation is partly through nuclear factor-kappa B (NF-kappaB) and phosphatidylinositol 3'-kinase and possibly involves TNFR1. (nih.gov)
  • occur
  • Furthermore, we have demonstrated that the tumor necrosis factor-α modulation of K Na channels does not occur at the level of SLICK channel gating but arises from possible posttranslational modification. (dovepress.com)