• Alteration in mucin secretion and/or the expression of mucin genes could be a causative factor in barrier compromise, as secreted polymeric mucin forms a physical barrier between luminal antigens and effector immune cells ( 13 ). (asm.org)
  • We have performed a case-control association study of three TNF-alpha gene polymorphisms in a group of Romanian psoriatic arthritis patients versus ethnically matched controls. (mdpi.com)
  • This meta-analysis was performed to clarify the association between tumor necrosis factor alpha ( TNF-α ) gene polymorphisms and open angle glaucoma (OAG) risks, and the association between the TNF-α level in aqueous humor (AH) and the risks of glaucoma. (molvis.org)
  • Both factors were described based on their ability to kill mouse fibrosarcoma L-929 cells. (wikipedia.org)
  • Also, exogenous IL-2 increases the response of NK cells to hk-LM or to IL-12 and TNF-alpha. (pnas.org)
  • Thus, these data indicate that macrophage production of TNF-alpha and IL-12 stimulates the release of IFN-gamma by NK cells and that IL-10 produced in response to hk-LM inhibits this response at the level of the macrophage and the NK cell. (pnas.org)
  • Tumor Necrosis Factor-producing T-regulatory Cells Are Associated With Severe Liver Injury in Patients With Acute Hepatitis A. Gastroenterology. (umassmed.edu)
  • These findings suggest that morphine primes microglia for enhanced production of TNF-alpha which could alter several functional activities of these cells within the brain. (aspetjournals.org)
  • Surprisingly, TNF-alpha was a very potent stimulator of the proliferation of CD34++CD38- cells and was the most potent synergistic factor for the IL-3-induced proliferation of these cells of all cytokines tested (IL-1, IL-6, granulocyte colony-stimulating factor, kit ligand). (rupress.org)
  • We hypothesize that in situations of the hematopoietic stress, TNF-alpha may abrogate the inhibitory effect of ambient TGF-beta in the bone marrow microenvironment to allow primitive stem cells to proliferate and differentiate in response to an increased demand for mature blood cells. (rupress.org)
  • furthermore, the expression pattern of adenocarcinomic cells (A549, H1650, or H1299 cells) was validated under the stimulation with tumor necrosis factor-alpha (TNFα) or dexamethasone (DEX), separately. (springer.com)
  • Tumor necrosis factor alpha increases epithelial barrier permeability by disrupting tight junctions in Caco-2 cells. (semanticscholar.org)
  • Caco-2 cells were plated onto Transwell microporous filters and treated with TNF-alpha (10 or 100 ng/mL) for 0, 4, 8, 16, or 24 h. (semanticscholar.org)
  • Following activation, MAPKs induce the expression of IL-1- and TNF-α-responsive genes by phosphorylating a number of transcription factors, including Jun, Fos, and ATF family members. (asm.org)
  • CONCLUSION: TNF-alpha stimulated tenascin-C expression through NF-kappaB signaling with RelA activation in cultured OA chondrocytes, suggesting involvement of tenascin-C in OA cartilage remodeling. (jrheum.org)
  • Interestingly, TNF-alpha-induced interferon regulatory factor (IRF)-1 activation was significantly inhibited by all calcium-mobilizing agents, BK, Thr and Tg. (le.ac.uk)
  • The primary function of TNF-alpha is to recruit other leukocytes to the site of infection and to stimulate their activation. (practo.com)
  • It was also shown that radiotherapy activates ADAM17 in non-small cell lung cancer, which results in shedding of multiple survival factors, growth factor pathway activation, and radiotherapy-induced treatment resistance. (wikipedia.org)
  • Also, using a salmonid-specific microarray platform (SFA2.0 immunochip) we observed that rtTNF alpha induces the expression of genes known to be involved in inflammation, proteolysis and tissue remodeling. (stir.ac.uk)
  • Furthermore, the expression of kallikrein, TOP-2, serine protease 23 and ADAM 22, genes that have been postulated to be involved in proteolytic and tissue remodeling processes during ovulation in trout, increases in follicles incubated in the presence of rtTNF alpha. (stir.ac.uk)
  • The use of luciferase-tagged IL-6 and RANTES promoter constructs demonstrated similar effects of Tg on IL-6 and RANTES genes in basal and TNF-alpha-stimulated conditions. (le.ac.uk)
  • Originally identified as a monocyte factor, our studies and those of others have demonstrated that B and T lymphocytes produce TNF-alpha when stimulated by a variety of inducers. (pnas.org)
  • These results demonstrate that low concentration BV possess a potent suppressive effect on anti-apoptotic responses of TNF-alpha/Act D-treated hepatocytes and suggest that these compounds may contribute substantial therapeutic potential for the treatment of liver diseases. (unboundmedicine.com)
  • Results The distribution of variables describing demographics, organ system dysfunction or failure, preinfusion Acute Physiology and Chronic Health Evaluation II score, number of organs failing at baseline, initial sites of infection, infecting microorganisms, antimicrobials used, and initial invasive procedures was similar among patients in the TNF-alpha MAb and placebo treatment arms. (ovid.com)
  • Chlamydia is the most prevalent bacterial sexually transmitted infection (STI) worldwide ( 1 ), and genital chlamydia is associated with significant reproductive morbidity, including tubal factor infertility. (asm.org)
  • As part of the innate immune response during infection, a number of cytokines such as tumor necrosis factor alpha (TNF alpha) and other immune factors, are produced and act on the reproductive system. (stir.ac.uk)
  • Dexamethasone treatment improves outcome in bacterial meningitis possibly by inhibiting IL-1 beta and TNF alpha. (jci.org)
  • Finally, overexpression of wild-type SAPKbeta was able to overcome the dexamethasone-induced block of TNF-alpha translation. (asm.org)
  • A novel mechanism by which dexamethasone inhibits translation of TNF-alpha is also revealed. (asm.org)
  • 1978 ). Morphological factors influencing transepithelial permeability: a model for the resistance of the zonula occludens. (biologists.org)
  • Furthermore, we have demonstrated that the tumor necrosis factormodulation of K Na channels does not occur at the level of SLICK channel gating but arises from possible posttranslational modification. (dovepress.com)
  • Thus, there is evidence that TNF-alpha priming of neutrophils for enhanced NAP-2- or rIL-8-promoted degranulation involves the antagonistic down-modulation of stimulus-induced rises in cAMP. (mysciencework.com)
  • Crespo D, Bonnet E, Roher N, MacKenzie S, Krasnov A, Goetz FW, Bobe J & Planas JV (2010) Cellular and molecular evidence for a role of tumor necrosis factor alpha in the ovulatory mechanism of trout, Reproductive Biology and Endocrinology, 8, Art. (stir.ac.uk)
  • Recent studies in animal models have indicated that TNF-alpha plays an important role in mediating the insulin resistance of obesity through its overexpression in fat tissue. (jci.org)
  • We have previously reported that gamma interferon and tumor necrosis factor alpha (TNF-α) synergistically inhibit HCMV replication in vitro. (asm.org)
  • We investigated regulation of tenascin-C expression by TNF-alpha through nuclear factor-alphaB (NF-kappaB) in OA cartilage in vivo and in vitro. (jrheum.org)
  • In the present study, we have examined for the first time the effects of TNF alpha in vitro in preovulatory ovarian follicles of a teleost fish, the brown trout (Salmo trutta). (stir.ac.uk)
  • Furthermore, we determined the in vitro effects of rtTNF alpha on follicle contraction and testosterone production in preovulatory brown trout ovarian follicles. (stir.ac.uk)
  • 01) release of TNF-alpha was observed when cultures were first primed with morphine for 24 h and then stimulated with lipopolysaccharide. (aspetjournals.org)
  • In this study we examined the expression pattern of TNF-alpha mRNA in adipose tissues from 18 control and 19 obese premenopausal women by Northern blot analysis. (jci.org)
  • Furthermore, the effects of weight reduction by dietary treatment of obesity on the adipose expression of TNF-alpha mRNA were also analyzed in nine premenopausal obese women, before and after a controlled weight-reduction program. (jci.org)
  • We found that TNF-alpha had a major effect on IL-10 mRNA production, inducing a 20- to 120-fold increase over baseline production. (jimmunol.org)
  • Most tissue eosinophils infiltrating nasal polyps were strongly positive for both TNF-alpha and MIP-1 alpha mRNA. (pubmedcentralcanada.ca)
  • By Northern blot analysis, highly enriched blood eosinophils from a patient with the idiopathic hypereosinophilic syndrome exhibited differential expression of TNF-alpha and MIP-1 alpha mRNA. (pubmedcentralcanada.ca)
  • These data confirm that three MAPK family members and their upstream activators are stimulated by LPS and demonstrate that JNK/SAPK is required for LPS-induced translation of TNF-alpha mRNA. (asm.org)