ProteinsHomeoboxRegulateHomeodomain transcription factorsSignaling pathwayExpressionDifferentiationGENETIC TRANSCRIPTIONRegulationReceptorSuperfamilyDiseasesEvolutionarily conservedProtein encoded by this geneMalignantMutationsChromosomePolymorphismsRegulatesDegradationPathwaysProgressionRepressorEvolutionaryInvestigateFamilyTranscriptionalNervous systemInteractionsCancer StemComplexesSomaticHighly conservedPosteriorDiseasePhosphoproteinCoordinateGrowthTargetRoleAdditionEnvironmental factorsHumanCell
Proteins18
- Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. (wikipedia.org)
- MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
- nonpolyposis CRC syndrome (Lynch syndrome), involve mutations Somatic mutations in the AXIN-complex proteins associated with in germline or in repair genes. (sagepub.com)
- In cells receive the WNT signal, β-catenin is stabilized and joins the addition, AXIN2 has also been independently associated with DNA-bound T-cell factor family of transcription proteins for tooth agenesis and non-syndromic cleft lip palate (NSCLP). (sagepub.com)
- Sirt1, the mouse homologue of yeast Sir2 deacetylates several non-histone proteins and plays roles in many key functions, including energy metabolism, differentiation, aging, and tumor suppression [ 10 ]. (biomedcentral.com)
- This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. (cancer-genetics.org)
- Furthermore, Smad proteins, transcriptional effectors of TGF-β signaling, are co-expressed and physically interact in the basal ganglia with Dlx homeodomain transcription factors, which are critical regulators of the differentiation, migration and survival of telencephalic GABAergic neurons. (biomedcentral.com)
- We also show that Dlx and Smad proteins localize to promoters/enhancers of a number of common telencephalic genes in vivo and that Smad proteins co-activate transcription with Dlx family members, except with certain mutated human DLX proteins identified in autistic individuals. (biomedcentral.com)
- In that regard, recent studies in non-neural cells have suggested the existence of functional interactions between Dlx proteins and Smad transcription factors, which are critical mediators of transforming growth factor-β (TGF-β) superfamily signaling pathways (Chiba et al. (biomedcentral.com)
- These proteins are transcription factors that control developmental pathways. (nih.gov)
- Proteins transcribed from the E1B region of ADENOVIRUSES which are involved in regulation of the levels of early and late viral gene expression. (nih.gov)
- Nuclear Factor 90 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
- A family of double-stranded RNA-binding proteins that are related to NFATC TRANSCRIPTION FACTORS. (ouhsc.edu)
- In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation. (ouhsc.edu)
- This graph shows the total number of publications written about "Nuclear Factor 90 Proteins" by people in this website by year, and whether "Nuclear Factor 90 Proteins" was a major or minor topic of these publications. (ouhsc.edu)
- Below are the most recent publications written about "Nuclear Factor 90 Proteins" by people in Profiles. (ouhsc.edu)
- Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). (childrensmercy.org)
- Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (childrensmercy.org)
Homeobox3
- In vitro, Mage-D1 not only binds to p75 neurotrophin receptor (p75NTR) but also to distal-less homeobox 1(Dlx1) and msh homeobox 1 (Msx1). (researchsquare.com)
- Further studies confirmed that p75NTR participates in the regulation of tooth development maybe by changing the activity of the key factor distal-less homeobox/msh homeobox (Dlx/Msx), and melanoma-associated antigen D1 (Mage-D1) seems to be play a role in the differentiation and mineralization of EMSCs 5 , 6 . (researchsquare.com)
- The disorder is an autosomal dominant genetic trait [6] caused by a mutation in the HLXB9 homeobox gene. (mdwiki.org)
Regulate6
- data indicate that linc00598 plays an important role in cell cycle regulation and proliferation through its ability to regulate the transcription of CCND2. (cusabio.cn)
- Mouse somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. (biomedcentral.com)
- Differentiated somatic cells can be reprogrammed into a pluripotent-like state through four defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc (OSKM) [ 1 , 2 ]. (biomedcentral.com)
- Sirt6 was previously reported to regulate many different biological processes like genome stability, glucose metabolism, and tumor suppression [ 18 ]. (biomedcentral.com)
- Signaling mechanisms mediated by the Transforming Growth Factor-β (TGF-β) superfamily regulate a variety of developmental processes. (biomedcentral.com)
- Nonetheless, the precise co-factors which help pSmad1/5 going into the particular nucleus to regulate Msx1 in dental mesenchymal cells remain unknown. (microtubule-signal.com)
Homeodomain transcription factors1
- Four members of the mouse Dlx protein family (Dlx1, 2, 5 and 6), part of the Antennapedia class of non-Hox homeodomain transcription factors, are expressed in the embryonic subpallium (Panganiban and Rubenstein 2002 ). (biomedcentral.com)
Signaling pathway2
- Although the etiology of dental agenesis The association between AXIN2 and CRC involves defects in the involved genetic and environmental factors, the genes more canonical WNT signaling pathway, which regulates and coordi- frequently associated with hypodontia in different populations are nates the AXIN complex for the degradation of β-catenin under 2,3 AXIN2, MSX1, PAX9, EDA, and WNT10. (sagepub.com)
- This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. (cancer-genetics.org)
Expression11
- Expression varies depending on the nature of the gene. (origene.com)
- showed that knocking out Mage-D1 can induce the expression of autophagy-related genes by enhancing the activity and differentiation of osteoclasts, thereby accelerating the process of periodontitis 23 . (researchsquare.com)
- Imposed upon this gross morphological description is the modern understanding of gene expression and protein elucidation, which bring about these developmental processes. (medscape.com)
- regulating the expression of target genes. (sagepub.com)
- Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancer-genetics.org)
- We will focus particularly on the roles of a tumor suppressor, neurofibromin 2 (NF2), whose expression is not only dependent on compartment-specific transcription factors, but is also subject to regulation by a Hippo-Yap feedback signaling circuit. (molcells.org)
- Within this region, their expression overlaps with that of Gad65 and Gad67 , genes encoding different forms of the rate-limiting enzyme required for production of GABA from glutamate. (biomedcentral.com)
- Results: In this study, we found high expression of the HOXD9 gene transcript in glioma cell lines and human glioma tissues by quantitative real-time PCR. (123dok.net)
- Using immunohistochemistry, we observed HOXD9 protein expression in human brain tumor tissues, including astrocytomas and glioblastomas. (123dok.net)
- Next, knockdown involving IPO7 canceled your upregulation associated with Msx1 caused by simply BMP4, whilst overexpression associated with Smad1 could recovery the particular Msx1 expression. (microtubule-signal.com)
- IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression. (harvard.edu)
Differentiation2
- Here we show that components of both bone morphogenetic protein/growth differentiation factor and TGF-β/activin/Nodal branches of TGF-β superfamily signaling are expressed in the developing subpallium. (biomedcentral.com)
- They play important roles in liver-specific transcription and are critical for CELL DIFFERENTIATION and METABOLISM. (umassmed.edu)
GENETIC TRANSCRIPTION2
- It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS. (bvsalud.org)
- It regulates GENETIC TRANSCRIPTION involved in METABOLISM of AMINO ACIDS in response to the increased concentration of LEUCINE. (rush.edu)
Regulation2
- There has been one previous report showing that overexpression of Sirt6 in aged human dermal fibroblasts could improve iPS generation via regulation of miR-766 transcription [ 19 ]. (biomedcentral.com)
- Taken jointly, our information indicated that the actual regulation of Msx1 through BMP4/pSmad1/5 signaling is mediated through importin7 within mouse button dental care mesenchymal tissue.Cytokines communicate carefully with each other and also enjoy a crucial role in the continuing development of sepsis. (microtubule-signal.com)
Receptor6
- Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the PTPRT gene. (wikipedia.org)
- The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. (cancer-genetics.org)
- Real-world patient-reported outcomes and physician satisfaction with poly (ADP-ribose) polymerase inhibitors versus chemotherapy in patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2-negative advanced breast cancer from the United States, Europe, and Israel. (jefferson.edu)
- Real-World Study of Regional Differences in Patient Demographics, Clinical Characteristics, and BRCA1/2 Mutation Testing in Patients with Human Epidermal Growth Factor Receptor?2-Negative Advanced Breast Cancer in the United States, Europe, and Israel. (jefferson.edu)
- Real-world study of patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2?Negative advanced breast cancer: Patient demographics, treatment patterns, adverse events, and physician-reported satisfaction in the United States, Europe, and Israel. (jefferson.edu)
- To better understand the molecular changes associated with AD, genome-wide association studies (GWAS) have identified hundreds of candidate genes linked to the disease, like the receptor tyrosine kinase EphA1. (sdbonline.org)
Superfamily2
- Together, these results suggest that TGF-β superfamily signaling plays a role in telencephalic GABAergic neuron development through functional interactions with Dlx transcription factors. (biomedcentral.com)
- Importin7 (IPO7) is amongst the critical members of importin β-superfamily, generally responsible for nucleocytoplasmic driving regarding RNAs and meats, which include transcription aspects. (microtubule-signal.com)
Diseases1
- González, F. 2019-10-16 00:00:00 BDJOpen www.nature.com/bdjopen ARTICLE OPEN Variations in AXIN2 predict risk and prognosis of colorectal cancer 1 2 3 4 3 5 L. Otero , E. Lacunza , V. Vasquez , V. Arbelaez , F. Cardier and F. González OBJECTIVE: Colorectal cancer (CRC) and hypodontia are frequent and different diseases with common genes are involved in their etiology. (sagepub.com)
Evolutionarily conserved1
- Hepatocyte nuclear factors are a family of evolutionarily conserved transcription factors that are preferentially expressed in HEPATOCYTES. (umassmed.edu)
Protein encoded by this gene1
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. (wikipedia.org)
Malignant1
- Gliomas, especially glioblastomas (GBMs), are the most malignant primary brain tumors[1]. (123dok.net)
Mutations2
- Mutations in this gene have been found in somatic sebaceous tumors. (cancer-genetics.org)
- In 2000 the first large series of Currarino cases was genetically screened for HLXB9 mutations, and it was shown that the gene is specifically causative for the syndrome, but not for other forms of sacral agenesis . (mdwiki.org)
Chromosome1
- A number sign (#) is used with this entry because pachyonychia congenita-4 (PC4) is caused by heterozygous mutation in the KRT6B gene (148042) on chromosome 12q13. (findzebra.com)
Polymorphisms2
- However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. (origene.com)
- Chromosomal abnormalities, HLA phenotypes, and polymorphisms of various genes have been associated with acne. (springer.com)
Regulates1
- DUSP6/MKP3 is a dual-specific phosphatase that regulates extracellular regulated kinase ERK1/2 and ERK5 activity, with an increasingly recognized role as tumor suppressor. (cancer-genetics.org)
Degradation1
- In RA, synovial cells express genes and erosive enzymes that contribute to joint degradation. (cellapplications.com)
Pathways1
- What pathways are this gene/protein implicaed in? (cancer-genetics.org)
Progression2
- Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. (cusabio.cn)
- When we reviewed pretransplantation factorHD, individual aspects including HCT-CI as well as Ps3 had been from the progression of candidemia, which implies which significantly not well patients together with transplantation-associated complications will build candidemia.Msx1 is vital for your upkeep of the actual odontogenic fate regarding dentistry mesenchymal cellular material, which is regulated simply by BMP/Smad1/5 signaling in a Smad4-independent way. (microtubule-signal.com)
Repressor2
- RE1-silencing transcription factor) (REST) is a transcription repressor that binds to REST DNA recognition element (RE-1) in 5'UTRs. (wikipedia.org)
- ETS2 repressor factor [Source. (gsea-msigdb.org)
Evolutionary1
- Phylogeny: Evolutionary relationships between organisms or genes or molecules. (top5binarybrokers.com)
Investigate1
- This study aspires to investigate regardless of whether IPO7 takes part within the atomic translocation of pSmad1/5 triggered through BMP4 to manage find more Msx1 phrase in computer mouse dental mesenchymal cellular material. (microtubule-signal.com)
Family5
- Mage-D1, also known as Dlxin-1 or NRAGE, was first cloned and identified as a new member of the type II melanoma-associated antigen gene family by Pold et al. (researchsquare.com)
- Structurally, Mage-D1 possesses the N-terminal sequence Mage homology domain 2 (MHD2), which is a highly conserved structure of the type II Mage gene family. (researchsquare.com)
- Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
- The prototype of this family is the mouse Brachyury (or T) gene product. (nih.gov)
- A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG. (ucdenver.edu)
Transcriptional1
- Particularly, by performing transcriptome analysis, we observed that several pluripotent transcriptional factors increase in knockout cell line, which explains the underlying loss of pluripotency in Sirt6-null iPS-like cell line. (biomedcentral.com)
Nervous system2
- PTPrho has been proposed to function during development of the nervous system and as a tumor suppressor in cancer. (wikipedia.org)
- In the embryo, zygotic transcription of Eph is confined to the nervous system. (sdbonline.org)
Interactions2
- This presents a starting point for studies into the underlying mechanisms of AD including interactions with other AD-associated genes, like Rho1, Ankyrin, Tau and APP with the potential to identify new targets for treatment. (sdbonline.org)
- Genetic factors are the main risk factors for NCPs, but environmental factors and abnormal gene-environment interactions can also lead to the development of NCPs. (chinagene.cn)
Cancer Stem1
- called either cancer stem cells (CSCs) or tumor-initiat-ing cells[3]. (123dok.net)
Complexes1
- Once activated, R-Smads accumulate in the nucleus where they associate with Smad4, a common partner for all R-Smads, to form transcription complexes. (biomedcentral.com)
Somatic1
- RNA sequencing was measured to identify the differential expressed genes due to loss of Sirt6 in somatic and pluripotent cells. (biomedcentral.com)
Highly conserved1
- The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). (biomedcentral.com)
Posterior1
- Exploration through a posterior sagittal approach demonstrated a silvery white epidermoid tumor (white arrow) occupying the presacral space. (mdwiki.org)
Disease1
- A large twin study demonstrated that 81 % of the variance of the disease was attributed to additive genetic effects, whereas the remaining 19 % was attributed to unique, unshared environmental factors [10]. (springer.com)
Phosphoprotein1
- The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). (jefferson.edu)
Coordinate1
- Basic helix-loop-helix (bHLH) myogenic regulatory factors coordinate the correct function and organization of many skeletal muscle functions. (biomedcentral.com)
Growth1
- The growth of individual tissue compartments is mainly related to the proliferation of the cells that comprise that compartment, whereas intercellular communication mediated by various morphogens and growth factors is responsible for coordination of growth between neighboring tissue compartments. (molcells.org)
Target1
- Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
Role2
- Role of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer. (cancer-genetics.org)
- NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription. (ouhsc.edu)
Addition1
- In addition, the particular tumour location, histological kind, and EUS image characteristics for every tumor T stage must guarantee focus.EUS gives reputable diagnostic accuracy and reliability inside the digestive tract most cancers stage. (microtubule-signal.com)
Environmental factors1
- Remarkably, at age 14 years, facial acne in girls was less influenced by genetic factors than in boys and was significantly influenced by common environmental factors [12]. (springer.com)
Human1
- Genes down-regulated by everolimus [PubChem=6442177] in mouse prostate tissue transgenically expressing human AKT1 gene [GeneID=207] vs untreated controls. (gsea-msigdb.org)
Cell1
- The HOXD9 gene was highly expressed in a side population (SP) of SK-MG-1 cells that was previously identified as an enriched-cell fraction of glioma cancer stem-like cells. (123dok.net)