Tumor microsatellite. Medical search. Frequent questions

Importantly, immune constituents of the tumor microenvironment (TME) can influence therapy response and cancer progression. (mdpi.com)
Such methods allow for systematic TIL enumeration and characterization of the tumor microenvironment in diverse cancer types and across thousands of tumors, an approach largely led by Ash Alizadeh, Ajit Johnson among others. (wikipedia.org)
To address that, the authors of this article performed single-cell RNA sequencing to explore the role of SHP2 in all cell types of tumor microenvironment (TME) from murine MC38 xenografts. (news-medical.net)
Herein, we comprehensively analysed the correlation of NRP expression with prognosis and tumour microenvironment landscape in 33 cancer types. (hindawi.com)
Our findings reveal that NRPs may be a potential prognostic marker associated with immune infiltration, tumour mutations, and tumour microenvironment, particularly in bladder urothelial carcinoma (BLCA). (hindawi.com)
We assessed a methylation panel of 5 genes to study their association to GC progression and microsatellite instability (MSI), and studied the role of RUNX3 in GC pathogenesis and the tumor immune microenvironment. (oncotarget.com)
Deep study of RUNX3 inflammation signaling could help in understanding inflammation and immune activation in the tumor microenvironment. (oncotarget.com)
Metabolic reprogramming is a common feature of tumor cells, which is crucial for rapid tumor growth and adaption to tumor microenvironment ( 5 , 6 ). (frontiersin.org)
The analysis of the immune microenvironment of CT26 KRASG12C+/+ tumors following RT and MRTX1257 showed an increase in the proportion of various cell subtypes including conventional CD4 + T cells, dendritic cells type 2 (cDC2) and inflammatory monocytes. (bvsalud.org)
Furthermore, the expression of PD-L1 was dramatically down-regulated within both tumor and myeloid cells, thus illustrating the polarization of the tumor microenvironment towards a pro-inflammatory and anti-tumor phenotype following the combined treatment. (bvsalud.org)
Distinct mutational profile and immune microenvironment in microsatellite-unstable and POLE-mutated tumors. (cdc.gov)
Other factors have been suggested to correlate with response to immunotherapy based on clinical and preclinical studies, including elevated type 1 helper T cell (Th1) tumoral gene signature, [ 11 ] and IFN-γ expression, possibly attributable to its ties to other proteins and cytokines within the tumor microenvironment. (medscape.com)

[ 12 ] Genetic alterations in dysplastic (atypical, Clark) melanocytic nevi appear complex and include loss of tumor suppressor genes and altered function of oncogenes, housekeeping genes, growth factors, and extracellular matrix proteins. (medscape.com)

Tumor mutation burden (TMB) is the total number of mutations identified in the genome of a tumor [1] . (idtdna.com)
MSI is the result of a malfunction in the DNA mismatch repair (MMR) system, which generates mutations in microsatellites. (idtdna.com)
The proposed role of HRPT2 as a tumor suppressor was supported by mutation screening in 48 parathyroid adenomas with cystic features, which identified three somatic inactivating mutations, all located in exon 1. (nih.gov)
Commonly these markers are individual genetic changes, such as driver mutations affecting oncogenes or tumor suppressor genes, or copy-number alterations thereof. (nature.com)
However, while DNA repair is often deficient in tumors, many DNA repair genes such as MLH1 , MGMT , BRCA1, or ATM do not commonly bear somatic mutations. (nature.com)
Some mutations in key onco-suppressor genes relate to the anatomical site of the tumour. (unboundmedicine.com)
Using CleanPlex amplicon sequencing technology for targeted DNA from Paragon Genomics, BioChain selected FFPE tissues from various tumors to screen against these two genes for mutations, which would facilitate our scientists with downstream applications, such as developing new screening method, target validation, digital spatial profiling and histology, or as control. (biochain.com)
BioChain has collected many tumor samples in both frozen and FFPE format with the aim of characterizing the DNA for BRCA mutations. (biochain.com)
These mutations in the microsatellite instability enzymes may be detected by genetic studies on peripheral blood or through immunohistochemical analysis of a biopsy specimen. (medscape.com)
There is a major problem with the latter method in that mutations are seen in sebaceous tumors in patients without the syndrome. (medscape.com)
The mutations are present in the tumor, even though the patient does not have germline mutation or neurofibromatosis. (medscape.com)
In a study of 450 CRC diagnosed under 50 years via the Ohio Colorectal Cancer Prevention Initiative, germline DNA analysis for mutations in 25 cancer susceptibility genes was done in addition to assessing microsatellite instability and/or immunohistochemistry for MMR deficiency. (cdc.gov)
These tumors may show microsatellite instability and have mutations in PTEN , PIK3CA , KRAS , and CTNNB 1. (msdmanuals.com)

Tumor mutational burden and microsatellite instability can also be determined. (frontagelab.com)

Therefore, it is thought that some TMB-H tumors are more responsive to immunotherapy though many factors, such as ethnicity, can influence response [2] . (idtdna.com)
The presence of lymphocytes in tumors is often associated with better clinical outcomes (after surgery or immunotherapy). (wikipedia.org)
Somatic second hits in tumors cause MMR deficiency, testing for which is used to screen for Lynch syndrome in colorectal cancer and to guide selection for immunotherapy. (lu.se)
Immunotherapy drugs such as checkpoint inhibitors, which are commonly used to treat melanomas, work to strengthen a patient's immune system so that it can prevent a tumor from "turning off" the ability of the immune system to fight it. (news-medical.net)
Moreover, the correlation between risk score and microsatellite instability, immunotherapy response, and drug sensitivity were analyzed. (frontiersin.org)
In addition, amino acid metabolism plays an important role in regulating tumor immunity and targeting amino acid metabolism may help to overcome immunotherapy resistance and improve existing therapies for COAD patients. (frontiersin.org)
The test can identify CRC patients with MSI-high tumors who may respond well to PD1 blockade immunotherapy , recently approved by the Food and Drug Administration. (cdc.gov)
Although promising, no immunotherapy drugs have been approved by the FDA to treat gastrointestinal malignancies outside of the recent approval of pembrolizumab for the treatment of patients with colon cancer with microsatellite instability (MSI). (medscape.com)
however, it is far from ideal because PD-L1-negative tumors may respond to immunotherapy and positive tumors may not. (medscape.com)

Second primary tumors (SPTs) have a significantly worse prognosis on patients with head and neck squamous cell carcinoma (HNSCC) (1). (bvsalud.org)

Of the 46 patients with MSI-high primary tumors, 37 (80.4%) also had MSI-high metastatic tumors, whereas 9 (19.6%) had microsatellite stable (MSS) metastatic tumors. (jnccn.org)
Turcot syndrome is an autosomal recessive disorder clinically characterized by the occurrence of primary tumors of the central nervous system and adenomatous colonic polyps during the first or second decades of life, with a spectrum of clinical features such as "café-au-lait" spots, axillary freckling, and hyperpigmented spots. (hindawi.com)

Immune checkpoint inhibitors (ICIs) are the standard treatment in patients with mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC). (nih.gov)
Abstract Tumour microsatellite instability (MSI) is useful in identifying patients with hereditary non-polyposis colorectal cancer (HNPCC) with defective DNA mismatch repair (MMR) genes. (unipd.it)
This study investigated the concordance in microsatellite instability (MSI) and mismatch repair (MMR) status between primary and corresponding metastatic colorectal cancer (CRC). (jnccn.org)
DNA mismatch repair/microsatellite instability (MSI) testing. (cancer.gov)
Mismatch repair-deficient tumors do not respond well to chemotherapy applied in the neoadjuvant, adjuvant, or metastatic settings. (cancer.gov)
Mismatch repair (MMR) behave as tumor suppressors and the most clinically relevant include MLH1, MSH2, MSH6, and PMS2 (Frolova et al. (alliedacademies.org)
As part of the multicenter, population-based Ohio Colorectal Cancer Prevention Initiative, tumor DNA was sequenced for 419 consecutive CRC cases undergoing standard universal tumor screening and germline genetic testing, and 46 patients with CRC known to have LS due to a germline mutation in a mismatch repair gene. (cdc.gov)
It has been also hypothesized that mismatch repair-deficient/microsatellite-unstable tumors are more responsive to PD-L1 blockade. (medscape.com)

Further Stratifying Patients With High Microsatellite Instability (MSI-H) In Colorectal Carcinoma with Tumor Mutation. (oncologytube.com)
Further Stratifying Patients With High Microsatellite Instability (MSI-H) In Colorectal Carcinoma with Tumor Mutational Burden (TMB): Cohort Of 22 Patients, Tumor Mutational Burden Was Si. (oncologytube.com)
url=https://oncologytube.com/channel/AnnualCancerMeeting/video/29057][img]https://oncologytubecom.cdn.ypt.me/videos/video_190602195519_3bbf/video_190602195519_3bbf.jpg?cache=15660580241691419079[/img]Further Stratifying Patients With High Microsatellite Instability (MSI-H) In Colorectal Carcinoma with Tumor Mutational Burden (TMB): Cohort Of 22 Patients, Tumor Mutational Burden Was Si. (oncologytube.com)
Alexa Schrock, PhD, of Foundation Medicine Discusses High Microsatellite Instability (MSI-H) in Colorectal Carcinoma Study: Tumor mutational burden is predictive of response to immune checkpoint inhibitors in MSI-high metastatic colorectal cancer. (oncologytube.com)
Over 90% of all colorectal cancers in HNPCC patients demonstrate a high microsatellite instability (MSI-H), which means at least 2 or more genes have been mutated in HNPCC families or atypical HNPCC families. (medscape.com)

The possible causes and genetic mechanisms of pulmonary carcinoid tumor development are unclear. (edgehill.ac.uk)
Our data indicate that real-time PCR with melting curve analysis is a reliable technique for LOH and MI detection and indicate that genetic errors at the MEN1 locus but also distal to it may be involved in the development of sporadic pulmonary carcinoid tumors. (edgehill.ac.uk)
In some cases, the tumor may need to be tested for particular genetic markers like PD-L1, dMMR, TMB, or pMMR to determine if pembrolizumab is right for you. (drugs.com)
One of the important molecular/genetic findings is the presence of microsatellite instability (MSI) in CRCs. (wjgnet.com)
Major efforts, like the AACR Project GENIE that launched in November last year, to collect, catalog, and link tumor genetic data with data on patient outcomes with the ultimate goal of empowering health care providers with the knowledge and resources to identify the right treatment for the right patient, were made. (aacr.org)

Lympho-depletion is thought to eliminate the negative effects of other lymphocytes that may compete for growth factors and decrease anti-tumor effects of the TILs, depleting regulatory or inhibitory lymphocyte populations. (wikipedia.org)
Recent study has demonstrated that inhibition of ASCT2 (function as a glutamine transporter) exerted a great anti-tumor effect in colorectal cancer ( 12 ). (frontiersin.org)

This is exemplified by a mutational signature associated with pathogenic variants in BRCA1 and BRCA2 genes 11 , 23 , thus identifying HR deficient tumors. (nature.com)
Immunohistochemistry was used to test the MMR status of both primary and matched metastatic tumors, and PCR analysis was performed to test MSI in patients with deficient MMR (dMMR) status. (jnccn.org)
In vivo, we used syngeneic models of subcutaneous CT26 KRASG12C+/+ tumors in BALB/c mice and T cell deficient athymic nu/nu mice to assess both the radio-sensitizing effect of MRTX1257 and its immunological features. (bvsalud.org)

Caris molecular profiling performs thorough molecular testing on DNA, RNA and proteins to identify the biomarkers driving a patient's tumor, and to compare the biomarkers with data from clinical studies around the world. (carislifesciences.com)
BRCA1 and BRCA2 are tumor suppressor genes found in humans which encode proteins that function in DNA repair. (biochain.com)
Results: A statistically significant relationship exists between MMR IHC proteins and tumor grade. (alliedacademies.org)
Types of molecules that can be analyzed in liquid biopsy samples include lipids, carbohydrates, small biomolecules, proteins, circulating nucleic acids, or tumor cells. (frontagelab.com)
NTRK fusion proteins are seen more commonly in microsatellite instability (MSI-H) tumors. (ccalliance.org)
A recent study compared the performance of tumor next-generation sequencing to the current multistep approach (using microsatellite instability (MSI) testing and/or immunohistochemistry (IHC) for MMR proteins). (cdc.gov)

Our findings suggest that HRPT2 is a tumor-suppressor gene, the inactivation of which is directly involved in predisposition to HPT-JT and in development of some sporadic parathyroid tumors. (nih.gov)
The coding region of the Bloom syndrome BLM gene and of the CBL proto-oncogene is mutated in genetically unstable sporadic gastrointestinal tumors. (lu.se)

Both MMR protein immunohistochemistry and microsatellite instability (MSI) analysis can be used. (lu.se)
Methods: Ninety-seven urothelial (61 upper tract and 28 bladder) tumors diagnosed from 1980 to 2017 in carriers of Lynch syndrome-associated pathogenic MMR variants and their first-degree relatives (FDR) were analyzed by MMR protein immunohistochemistry, the MSI Analysis System v1.2 (Promega), and an amplicon sequencing-based MSI assay. (lu.se)
We also studied RUNX3 expression by immunohistochemistry (IHC) in 40 samples, and validated differences in methylation levels between tumor, normal, and immune tissue in 14 additional samples. (oncotarget.com)
The tumor testing (ie, immunohistochemistry, MSI, germline testing, and BRAF mutation testing), screening, and prophylactic surgery all help to reduce the risk of death in patients with HNPCC or Lynch syndrome. (medscape.com)

This study, published in Annals of Oncology, shows that tumor mutational burden (TMB) may help inform treatment decisions for MSI-H metastatic colorectal cancer patients. (oncologytube.com)
It is estimated approximately 5-15% of colorectal cancer patients have tumors that score as either MSI-H or dMMR when testing is performed. (merck.com)

For a more comprehensive and unbiased proteomic characterization, the Clinical Proteomic Tumor Analysis Consortium performed mass spectrometry-based proteomic and/or phosphoproteomic analyses of tumor tissues from patients with colon, breast, and ovarian cancers, which demonstrated that proteomic signatures can provide information that can further stratify patients. (genomeweb.com)
We first isolated genomic DNA from the frozen tumor tissues and then processed them for subsequent NGS characterization using Paragon's BRCA1&2 panel. (biochain.com)

Clinical characteristics and outcomes of uterine tumors resembling ovarian sex-cord tumors (UTROSCT): a systematic review of literature. (nih.gov)

Consecutive patients with metastatic CRC who had both primary and metastatic tumors diagnosed at our institution in January 2008 through December 2016 were identified. (jnccn.org)
the median overall survival of MSI-high and MSS metastatic tumors was 21.3 and 21.6 months, respectively ( P =.774). (jnccn.org)

In 1966, Dr. Lynch and colleagues described familial aggregation of colorectal cancer with stomach and endometrial tumors in 2 extended kindreds and named it cancer family syndrome. (medscape.com)

2015). MMR results in a strong mutator phenotype known as microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers (Yamamoto & Imai, 2015). (alliedacademies.org)
RÉSUMÉ La présente étude visait à identifier le statut de deux marqueurs principaux de l'instabilité des microsatellites (gènes de réparation hMSH2 et hMSH6 ) dans des cas de cancers colorectaux opérés à l'hôpital universitaire King Khalid de Riyad (Arabie saoudite) entre 2007 et 2009. (who.int)

These results highlight the importance of considering tumor phenotype in studies of risk factors for CRC. (pedigree.org.au)

Mechanistically, EPB41L4A-AS2, acting at least in part as a tumor suppressor, upregulated tumor suppressor gene expression. (cancerindex.org)
For selected markers and cases, tumour tissue was compared to normal tissue to look for allelic loss indicative of a tumour suppressor gene. (lu.se)
One family contributed suggestive LOD scores (LOD 2.63 to 3.03, dominant model) at all these regions, without consistent evidence of a tumour suppressor gene. (lu.se)

Measurements and Main Results: MAs in DNA from tumor tissues and EBC of each patient with cancer presented an overlapping profile of loss of heterozygosity and microsatellite instability. (unifg.it)
We employed, for the first time in this setting, real-time PCR with melting curve analysis in order to identify loss of heterozygosity (LOH) or microsatellite instability (MI) in two polymorphic markers (PYGM, D11S449) at the MEN1 locus and one additional marker (D11S906) of a putative oncosuppressive region distal to the MEN1 gene. (edgehill.ac.uk)

Their functions can dynamically change throughout tumor progression and in response to anticancer therapy TILs are implicated in killing tumor cells. (wikipedia.org)
Therefore, dysregulation of the angiogenic process has been linked to tumour development and progression [ 1 ]. (hindawi.com)

In some patients, tumors have regressed and disappeared with checkpoint inhibitors. (drugs.com)

Microsatellite instability (or MSI) is defined by the National Cancer Institute as a change that occurs in the DNA of certain cells, such as tumor cells, in which the number of repeats of microsatellites (short, repeated sequences of DNA) is different from the number of repeats that was in the DNA when it was inherited. (merck.com)

The researchers collected paired tumor and adjacent normal tissues, as well as blood samples, from 80 patients with EOGCs under 45 years of age. (genomeweb.com)
For each patient, the team performed exome sequencing of the tumors and peripheral blood mononuclear cells, as well as mRNA sequencing of the paired tumor and adjacent normal tissues. (genomeweb.com)
The researchers also performed global proteome, phosphoproteome, and N-glycoproteome profiling of paired tumor and adjacent normal tissues using liquid chromatography-tandem MS analyses. (genomeweb.com)

Another predictive cancer biomarker is microsatellite instability (MSI). (idtdna.com)
Cancer precision medicine draws on the presence of somatically acquired changes in the tumor, which serve as predictive markers of response to drugs and other therapies. (nature.com)

Results: Among the 97 urothelial tumors, 86 (88.7%) showed immunohistochemical MMR loss and 68 were successfully analyzed by the Promega MSI assay, of which 48 (70.6%) were MSI-high and 20 (29.4%) were MSI-low/microsatellite stable. (lu.se)
Immunohistochemical study of microsatellite instability was done with antibodies to hMSH2 and hMSH6 . (who.int)

Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and stable (MSS) phenotypes. (news-medical.net)
Human glioblastoma (GBM) is the most common primary malignant brain tumor. (nature.com)
We hypothesized that tumour behaviour in the rectum may differ in terms of pathogenesis and malignant propensity. (unboundmedicine.com)

A minor subpopulation of cancer cells, known as glioma stem-like cells (GSCs), are thought to play a major role in tumor relapse due to their stem cell-like properties, their high resistance to conventional treatments and their high invasion capacity. (nature.com)

Methods: Ninety-seven urothelial (61 upper tract and 28 bladder) tumors diagnosed from 1980 to 2017 in carriers of Lynch. (lu.se)

Tumor immune infiltration can also be determined using gene expression methods like Microarray or RNA Sequencing through deconvolution methods such as CIBERSORT. (wikipedia.org)
However, concordance between methods can vary for different tumor types. (lu.se)
Methods: GWS was performed using 811 microsatellite markers providing about five centiMorgan (cM) resolution. (lu.se)

This cut also shows severe tumor infiltration of the colonic mesentery surrounding the mesenteric and retroperitoneal vessels. (medscape.com)

Genetics the status of 2 major microsatellite in- Diamino benzidine was used as a chro- may play a role in up to 30% of cases [3]. (who.int)

KEYTRUDA is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumor cells and healthy cells. (merck.com)
Tumor-infiltrating lymphocytes (TIL) are white blood cells that have left the bloodstream and migrated towards a tumor. (wikipedia.org)
CD3 has been used to detect lymphocytes in tumor samples. (wikipedia.org)
The process can also involve a preliminary chemotherapy regimen to deplete endogenous lymphocytes in order to provide the adoptively transferred TILs with enough access to surround the tumor sites. (wikipedia.org)

Their abundance varies with tumor type and stage and in some cases relates to disease prognosis. (wikipedia.org)
An active immune environment within the tumor often indicates a better prognosis as can be determined by the Immunological constant of rejection. (wikipedia.org)
EBV-positive tumors have a higher frequency of Crohn's disease-like lymphoid reaction that correlates with an improved prognosis in patients with gastric cancer. (medscape.com)

Sites in Virginia and Washington opened their doors in June 2023 seeking 100 participants with a range of solid tumor types. (medscape.com)

Tumors with high TMB (TMB-H) have been shown to have more 'neo-antigens' which coat the tumor cell that leads to the identification of tumor cells by the immune system. (idtdna.com)
Autologous TIL therapy for metastatic melanoma has broad T cell recognition of both defined and undefined tumor antigens against all human leukocyte antigen (HLA) restrictions. (wikipedia.org)
TILs can not only recognize over-expressed self/melanocyte differentiation antigens, such as Melan-A/MART-1 (melanoma-specific), gp100, tyrosinase, and survivin, but TILs can also recognize other unknown antigens specific to the tumor and individual patient. (wikipedia.org)
AP2S1 , P3H4 , and RAC3 were identified as candidate tumor-specific antigens for BLCA. (frontiersin.org)
AP2S1 , P3H4 , and RAC3 were identified as candidate tumor-specific antigens, and patients with the BCS2 and BCS1A subtypes were identified as candidate populations for mRNA vaccines. (frontiersin.org)

This link is typified by microsatellite instability and proximal neoplasia. (unboundmedicine.com)

Sequencing data were available in a selected subset of tumors in order to verify the reliability of real-time PCR analysis. (edgehill.ac.uk)
Of the 11 tumors with retained MMR protein expression, four were MSI-low/MSI-high or MSI-high by the Promega assay or one of the sequencing-based assays. (lu.se)
Data from whole transcriptome sequencing of 33 breast specimens in the Harbin Medical University Cancer Center cohort and The Cancer Genome Atlas was applied to identify and validate the landscape of tumor suppressor long noncoding RNAs, which was further validated by The Cancer Genome Atlas pancancer data including 33 cancer types and 12,839 patients. (cancerindex.org)
Universal Screening for Lynch Syndrome: Can Tumor Sequencing Have a Larger Public Health Impact on Treatment and Prevention of Colorectal Cancer? (cdc.gov)
In the meantime, new genomic research could be changing clinical and public health approaches to reducing the burden of colorectal cancer from LS and in general, by shifting the laboratory testing approach toward tumor next generation sequencing. (cdc.gov)
A universal tumor sequencing test can identify LS patients as well as guide treatment of CRC patients who do not have LS. (cdc.gov)

Epigenetic alterations, such as DNA methylation are considered pivotal in the inactivation of tumor-related genes. (oncotarget.com)
The methylation status of 47 promoter-CpG islands was studied through MALDI-TOF mass spectrometry analysis in 35 Microsatellite stable (MSS) GC, 26 MSI, and 18 cancer-free samples (CFS), and 6 MSS GC and 4 MSI GC cell lines. (oncotarget.com)

The widespread implementation of colorectal tumor testing helps to identify families with HNPCC or Lynch syndrome. (medscape.com)

3p microsatellite signature in exhaled breath condensate and tumor tissue of patients with lung cancer. (unifg.it)
Objectives: To verify whether MAs analyzed in DNA from EBC reflect a profile of alterations present in tumor tissue of NSCLC. (unifg.it)
All subjects underwent allelotyping on DNA from whole blood, EBC, and lung tissue removed for histologic diagnosis by analyzing a panel of five microsatellites located in chromosomal region 3p. (unifg.it)
In several cases, samples may be available as matched sets which include the adjacent normal/primary tumor tissue along with plasma from the same donor. (biochain.com)
6 , 25 , 30 ] Measured in millimeters, CRM is defined as the retroperitoneal or peritoneal adventitial soft-tissue margin closest to the deepest penetration of the tumor. (cancer.gov)
Occasionally, the tumor invades the adipose tissue of the orbit. (medscape.com)

This radiolabeled monoclonal antibody from Telix Pharmaceuticals targets carbonic anhydrase IX (CAIX), an enzyme that regulates cell proliferation and is highly expressed in many tumor types. (medscape.com)

Studies have shown that a high expression of neuropilins (NRPs) promotes tumourigenesis and tumour malignancy. (hindawi.com)
In 10% of these individuals, the tumor progresses to malignancy. (medscape.com)

and tumors with chromosomal instability showing aneuploidy and amplifications of genes encoding receptor tyrosine kinases, the researchers said. (genomeweb.com)

Rationale: Our group has recently demonstrated the possibility of studying microsatellite alterations (MAs) of 3p in theDNAof exhaled breath condensate (EBC) of patients with non-small cell lung cancer (NSCLC). (unifg.it)
This is a first step towards the use of new combinatorial strategies using KRAS inhibitors and RT in KRASG12C mutated tumors, which are the most represented in NSCLC with 14% of patients harboring this mutational profile. (bvsalud.org)

In addition, pembrolizumab helped to shrink tumors: 33% of patients who received pembrolizumab had tumor shrinkage, compared to 12% treated with ipilimumab. (drugs.com)
In a phase II study of pembrolizumab in patients with microsatellite-high (MSI-H) solid tumors, the objective response rate was 39.6% (95% CI = 31.7% to 47.9%), including 7.4% complete responses (CRs) and 32.2% partial responses (PRs). (medscape.com)
[ 10 ] Based partly on this study, pembrolizumab was recently approved by the FDA for treatment of advanced MSI-H tumors. (medscape.com)

Conclusion: a complete panel of ten markers including four dinucleotide and six mononucleotide microsatellites allows accurate evaluation of tumor MSI status. (unipd.it)
ABSTRACT This study aimed to identify the status of 2 major microsatellite instability markers (repair genes hMSH2 and hMSH6 ) in colorectal cancer cases operated at King Khalid University Hospital, Riyadh, Saudi Arabia between 2007 and 2009. (who.int)

Our studies demonstrate that SLC25A21 plays a significant role as a tumor suppressor in KRAS-mutant CRC by antagonizing Gln-dependent anaplerosis to limit GTP availability for KRAS activation, which suggests potential alternative therapeutic strategies for KRAS-mutant CRC. (bvsalud.org)

Objective To evaluate the prognostic value of tumor budding and tumor-stroma ratio (TSR) in resected pulmonary metastases of colorectal carcinoma (CRC). (jyu.fi)
A multidimensional bioinformatics analysis was performed to examine the relationship between NRP genes and prognostic and pathological features, tumour mutational burden (TMB), microsatellite instability (MSI), and immunological features based on public databases and find the potential prognostic value of NRPs in pancancer. (hindawi.com)
Next, the expression model, prognostic roles, potential biological functions and epigenetic regulation of tumor suppressor long noncoding RNAs were investigated and validated in the breast cancer and pancancer cohorts. (cancerindex.org)

The treatment for bladder cancer is dependent on diagnosis via transurethral resection of bladder tumor (TURBT). (frontiersin.org)
The tumors may be present at the time of diagnosis, or delayed. (medscape.com)

Reports have suggested that these associations may differ by tumor molecular subtype, with stronger associations for microsatellite unstable (MSI-H) tumors. (pedigree.org.au)

These 80 tumors included 74 diffuse, three intestinal, two mixed type, and one inflammatory myoblastic tumor. (genomeweb.com)

Anatomy4

Organisms1

Diseases6

Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes18

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Health Care1

Microenvironment12

Housekeeping genes1

Mutations13

Mutational Burden and Microsatellite Instability1

Immunotherapy9

Squamous cell Carc1

Primary tumors2

Mismatch Repair8

High Microsatellite Instability5

Genetic5

Anti-tumor2

Deficient3

Proteins6

Sporadic2

Immunohistochemistry4

Colorectal Cancer Patients2

Characterization2

Ovarian1

Metastatic tumors2

Endometrial1

Cancers2

Phenotype1

Suppressor gene3

Loss of heterozygos2

Progression2

Checkpoint Inhibitors1

Repeats1

Tissues3

Predictive2

Immunohistochemical2

Malignant3

Role in tumor1

Urothelial1

Methods3

Infiltration1

Genetics1

Lymphocytes4

Prognosis3

Solid tumor1

Antigens5

Neoplasia1

Sequencing6

Methylation2

Lynch1

Tissue6

Cell proliferation1

Malignancy2

Chromosomal1

NSCLC2

Pembrolizumab3

Markers2

KRAS1

Prognostic3

Diagnosis2

Unstable1

Intestinal1