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  • macrophage
  • Depending on the mode of tumor cell death macrophage polarization ranges from the extremes of pro-inflammatory activation toward anti-inflammatory/immuno-suppressive activation. (ovid.com)
  • Clinical trials of drugs that target the signals that drive inflammatory cells into the tumors, such as macrophage colony stimulating factor 1, are under way. (aacrjournals.org)
  • Epithelial-Mesenchyma
  • There is certainly evidence that, e.g., acquired genetic changes can make cancer cells resistant to drugs from the get-go, but if subpopulations within the tumor undergo epithelial-mesenchymal transition, that can also make them more resistant. (aacrjournals.org)
  • growth
  • Additional chapters describe the influence of infiltrating cells of the immune system on tumor growth. (springer.com)
  • Sialidase treatment alone enhanced the growth of tumors in mice and increased the number of tumor-associated MDSCs, which could be interpreted that sialidase should not be a component of therapy. (sciencemag.org)
  • However, combining sialidase with STAT3 inhibitors prevented the growth of typically STAT3 inhibitor-resistant sarcoma in mice, and tumor-associated MDSCs were undetectable after the combination treatment. (sciencemag.org)
  • What's more, these proteases can free additional mitogens that are sequestered in the ECM, further stimulating tumor growth (Hanahan and Coussens, 2012). (abcam.com)
  • Roles of nitric oxide in tumor growth," Proceedings of the National Academy of Sciences of the United States of America , vol. 92, no. 10, pp. 4392-4396, 1995. (hindawi.com)
  • That environment - with its fostering of cell accumulation and growth - likely encourages tumors to form. (cityofhope.org)
  • There are no a priori reasons why such a cellular microenvironment might not contain genetic or functional polymorphisms that promote the growth of the cancer cells, or even mutations representing forme fruste malignancies. (cityofhope.org)
  • According to the growth rate hypothesis (GRH), increased phosphorus availability in an ecosystem, such as the tumor micro-environment, may promote selection within the tumor for a more proliferative and thus potentially more malignant phenotype. (plos.org)
  • The aim of our study was to evaluate the impact of inflammatory tumor microenvironment on the expression of vascular endothelial growth factor receptor 2 (VEGFR-2). (hindawi.com)
  • But death ligands crosslinking their receptors also induce inhibition of apoptosis and activation of the transcription factor, NFkappaB, with a subsequent burst of pro-inflammatory cytokine production and tumor growth promotion. (biomedsearch.com)
  • Recent evidence suggests that the white blood cell-selective PI3Kγ and PI3Kδ isoforms have an important role in regulating the immune-suppressive, tumor-associated myeloid cell and regulatory T cell subsets, respectively, and as a consequence are also critical for solid tumor growth. (mdpi.com)
  • Most of these cells have the capacity to slow down tumors, but they receive signals that push them in the other direction-promoting tumor growth," explains Mikala Egeblad, PhD, who studies tumor microenvironment at New York's Cold Spring Harbor Laboratory. (aacrjournals.org)
  • therapeutics
  • Originating from a partnership between Ludwig Cancer Research and de Duve Institute at the Université Catholique de Louvain, iTeos Therapeutics SA ( http://www.iteostherapeutics.com ) is a private biotechnology company targeting immunosuppression mechanisms in the tumor microenvironment for the development of innovative immune-oncology therapeutics. (prweb.com)
  • inflammatory
  • LIGHT-fusion antibodies stimulated the abundance of inflammatory cytokines in tumor homogenates, and this positively correlated with increased abundance of infiltrating lymphocytes. (sciencemag.org)
  • Target dependence on inflammatory tumor microenvironment has to be taken into consideration when treatment approaches that block VEGFR-2 signaling are designed. (hindawi.com)
  • vivo
  • MG1-Maraba is a potent and versatile oncolytic virus capable of lethally infecting a variety of prostatic tumor cell lines alongside primary PCa biopsies and exerts direct oncolytic effects against large TRAMP-C2 tumors in vivo . (nih.gov)
  • Current in vitro models of tumor drug delivery are oversimplified and show poor correlation with in vivo performance," said Prabhakar Pandian, Ph.D., CFDRC principal investigator. (marketwired.com)
  • The SynVivo-Tumor assays captured the in vivo response, while the static well plate assays did not, clearly highlighting why static well plate assays are not suitable for predicting drug vehicle delivery in vivo . (marketwired.com)
  • cancers
  • Within the tumor microenvironment, where cancers grow, acquire the ability to metastasize and develop resistance to treatment, there is a lot of cross-talk. (eurekalert.org)
  • Although considered as rare tumor entity, about 27700 new primary CNS cancers are diagnosed each year in Europe [ 1 ]. (hindawi.com)
  • Whether endometriosis-associated ovarian cancers develop from the molecular transformation of endometriosis or develop because of the endometriotic tumor microenvironment remain unknown. (mdpi.com)
  • In this review, we will describe the unique molecular features of endometriosis-associated ovarian cancers, the endometriotic tumor microenvironment, and available model systems for endometriosis-associated ovarian cancers. (mdpi.com)
  • resistance
  • Led by Muller Fabbri, MD, PhD, of the Children's Center for Cancer and Blood Diseases and The Saban Research Institute of CHLA, and published in the Journal of the National Cancer Institute on May 13, the study looked at how exosomic miRNAs released within the tumor environment affect resistance to chemotherapy. (eurekalert.org)
  • The goal of this study was to assess whether, and to what extent, exosomic miRNAs are involved in the development of drug resistance through the tumor microenvironment. (eurekalert.org)
  • Or does something happen in the microenvironment to cause resistance? (aacrjournals.org)
  • Inhibition
  • Therefore, pharmacological inhibition of the Class (I) PI3K family in the tumor microenvironment can be a highly attractive anti-cancer strategy and isoform-selective PI3K inhibitors may act as potent cancer immunotherapeutic and anti-angiogenic agents. (mdpi.com)
  • organs
  • Just as organs within the body require constant blood supply to function normally, a growing tumor also requires a supply of blood to provide oxygen and blood-borne mitogens, and remove toxic metabolites. (abcam.com)
  • Furthermore, the most destructive of these tumors are not found in the organ of origin of the cancer, but rather in distant, noncontiguous organs. (cityofhope.org)
  • tumor's
  • Scientists at the University of North Carolina at Chapel Hill now think that failure may have less to do with the drugs and tumors than it does the tumor's immediate surroundings. (eurekalert.org)
  • efficacy
  • This suggests that composition of the tumor as a whole needs to be evaluated in order to maximize the efficacy of therapy. (plos.org)
  • The SynVivo-Tumor platform," said Kapil Pant, Ph.D., director of biomedical technology at CFDRC, "enables critical applications both in basic research, where it can be used to develop next generation delivery vehicles, and in drug discovery and development where it can be used to study drug efficacy in realistic tumor microenvironments. (marketwired.com)
  • novel
  • and critically evaluate novel targets for imaging or therapeutic intervention that would be of use to the tumor microenvironment community and pharmaceutical industry. (springer.com)
  • Prostate cancer (PCa) was estimated to have the second highest global incidence rate for male non-skin tumors and is the fifth most deadly in men thus mandating the need for novel treatment options. (nih.gov)
  • HUNTSVILLE, AL--(Marketwire - Dec 10, 2012) - CFD Research Corporation has been awarded a $1.3M grant from the National Institutes of Health to develop their novel in vitro tumor model. (marketwired.com)
  • Glioblastoma
  • Glioblastoma multiforme (GBM) is one of the most angiogenic tumors. (hindawi.com)
  • Out of these, glioblastoma multiforme (GBM) is the most aggressive and lethal type of a brain tumor in adults that accounts for approximately 20% of all malignant primary CNS tumors and 82% of high grade (WHO grades III and IV) gliomas [ 2 , 3 ]. (hindawi.com)