Loading...
  • serum
  • FDA is also announcing that it has issued an order in the form of a letter to Centocar, Inc., reclassifying serum tumor markers into class II. (biomedsearch.com)
  • Serum p53 autoantibodies as prognostic marker in patients with oesophageal carcinoma. (biomedsearch.com)
  • Tumor markers can be determined in serum or rarely in urine or other body fluids, often by immunoassay but other techniques such as enzyme activity determination are sometimes used. (wikipedia.org)
  • However, the serum levels are raised in some types of cancer, which means that it can be used as a tumor marker in clinical tests. (wikipedia.org)
  • citation needed] Serum from individuals with colorectal carcinoma often has higher levels of CEA than healthy individuals (above approximately 2.5 µg/L). CEA measurement is mainly used as a tumor marker to monitor colorectal carcinoma treatment, to identify recurrences after surgical resection, for staging or to localize cancer spread through measurement of biological fluids. (wikipedia.org)
  • Hence, elevated serum alkaline phosphatase activity may be a marker for inflammation because of its association with elevated levels of CRP. (wikipedia.org)
  • genetics
  • CALYM covers all stages of lymphoma research and development (R&D), from fundamental and preclinical research (including new biological targets) to clinical research (up to international phase III registration trials) and also carries out biological studies associated with clinical trials: diagnostics, genetics, immunomonitoring, and pharmacogenomics. (wikipedia.org)
  • Antigen
  • In this study, we evaluated the prognostic value of the tumour marker, tissue polypeptide-specific antigen (TPS), in 203 patients with non-small cell lung cancer (NSCLC), and related this to several other known prognostic factors. (biomedsearch.com)
  • reclassification of tumor-associated antigen immunological test system--FDA. (biomedsearch.com)
  • The Food and Drug Administration (FDA) is announcing that it is codifying the reclassification of tumor-associated antigen immunological test systems intended as an aid in monitoring patients for disease progression or response to therapy or for the detection of recurrent or residual disease from class III (premarket approval) to class II (special controls). (biomedsearch.com)
  • Carcinoembryonic Antigen as a Marker for Colorectal Cancer: Is It Clinically Useful? (wikipedia.org)
  • Tumor markers including alphafetoprotein (AFP), Beta Human Chorionic Gonadotropin (HCG), Carcinoembionic Antigen (CEA), CA 125, Prostate specific antigen (PSA). (wikipedia.org)
  • clinical
  • This study examined, in a randomized double-blind placebo-controlled clinical trial, the effects of dietary flaxseed on tumor biological markers and urinary lignan excretion in postmenopausal patients with newly diagnosed breast cancer. (aacrjournals.org)
  • MIB-1 as a proliferative marker in transitional cell carcinoma of the bladder: clinical significance. (biomedsearch.com)
  • If repeated measurements of tumor marker are needed, some clinical testing laboratories provide a special reporting mechanism, a serial monitor that links test results and other data pertaining to the person being tested. (wikipedia.org)
  • Interlaboratory proficiency testing for tumor marker tests, and for clinical tests more generally, is routine in Europe and an emerging field. (wikipedia.org)
  • Optimization and exploitation of clinical research-related tools to accelerate development, registration and market access of drug candidates (network of early phase clinical trials, clinical databases, biological collections, network and platform of centralized proofreading of imaging, biometry, long term follow-up of patients) CALYM has a history of R&D partnerships, that have led to new indications and new drug registration: rituximab, alpha-interferon, etc. (wikipedia.org)
  • cells
  • The aim of this study was to assess the expression of cytokeratins in mucoepidermoid carcinoma, comparing to cytokeratin expression in normal salivary glands, in order to establish a possible correlation between tumor cells immunostaining and mucoepidermoid carcinoma histogenesis and differentiation. (mendeley.com)
  • Quantification of NG2 expression in 74 GBM biopsies from newly diagnosed and untreated patients revealed that 50% express high NG2 levels on tumour cells and associated vessels, being associated with significantly shorter survival. (biomedsearch.com)
  • NG2 was frequently co-expressed with nestin and vimentin but rarely with CD133 and the NG2 positive tumour cells harboured genetic aberrations typical for GBM. (biomedsearch.com)
  • The tumor cells are negative for E-cadherin, but positive for CD138 expression. (biomedsearch.com)
  • Immunocytochemical detection of isolated tumor cells in peripheral blood and bone marrow is currently the most established method for monitoring early dissemination in epithelial cancer. (biomedsearch.com)
  • In this study we used an immunomagnetic selection technique to develop an enrichment model for disseminated tumor cells in blood. (biomedsearch.com)
  • The eluted cytokeratin 8+ tumor cells were detected by flow cytometry and immunocytochemistry. (biomedsearch.com)
  • Tumor markers can be produced directly by the tumor or by non-tumor cells as a response to the presence of a tumor. (wikipedia.org)
  • One way that MUC16 helps the growth of tumors is by suppressing the response of natural killer cells, thereby protecting cancer cells from the immune response. (wikipedia.org)
  • Further evidence that MUC16 can protect tumor cells from the immune system is the discovery that the heavily glycosylated tandem repeat domain of MUC16 can bind to galectin-1 (an immunosuppressive protein). (wikipedia.org)
  • MUC16 is also thought to participate in cell-to-cell interactions that enable the metastasis of tumor cells. (wikipedia.org)
  • Since mesothelin is also expressed by tumor cells, MUC16 and mesothelial interactions may aid in the gathering of other tumor cells to the location of a metastasis, thus increasing the size of the metastasis. (wikipedia.org)
  • Experiments reintroducing SIM2s in human breast cancer cells allowed for the tumor suppressive characteristics to be observed. (wikipedia.org)
  • PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets, as well as in all cells with a high rate of nucleic acid synthesis, such as normal proliferating cells, embryonic cells, and especially tumor cells. (wikipedia.org)
  • When PKM2 is mainly in the less active dimeric form, which is the case in tumor cells, all glycolytic intermediates above pyruvate kinase accumulate and are channelled into synthetic processes, which branch off from glycolytic intermediates such as nucleic acid-, phospholipid-, and amino acid synthesis. (wikipedia.org)
  • Nucleic acids, phospholipids, and amino acids are important cell building-blocks, which are greatly needed by highly proliferating cells, such as tumor cells. (wikipedia.org)
  • In tumor cells, PKM2 is mainly in the dimeric form and has, therefore, been termed Tumor M2-PK. (wikipedia.org)
  • The dimerization of PKM2 in tumor cells is induced by direct interaction of PKM2 with different oncoproteins (pp60v-src, HPV-16 E7, and A-Raf). (wikipedia.org)
  • tissue
  • Though ANT2 is highly conserved and ubiquitously expressed, its expression levels and, accordingly, biological function, may vary depending on tissue type. (wikipedia.org)
  • metastatic
  • Advances in diagnostic techniques, genomics, and proteomics enable a window into subcellular mechanisms driving hyperproliferation, metastatic capabilities, and tumor angiogenesis. (biomedsearch.com)
  • renal
  • Tumour-like smooth muscle proliferations were seen surrounding muscular arteries (eight), occasionally admixed with fat extending from the renal sinus mimicking angiomyolipoma. (biomedsearch.com)
  • protein
  • This distinction is indicated by the markers of inflammations specifically from C-reactive protein (CRP) with elevated levels of alkaline phosphatase. (wikipedia.org)
  • The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. (wikipedia.org)
  • primary
  • With this assay and mutation assays for the FGFR3 and PIK3CA oncogenes, we screened primary bladder tumors of 257 patients and 184 recurrences from 54 patients. (biomedsearch.com)
  • Additionally, in primary tumors p53 expression was obtained by immunohistochemistry. (biomedsearch.com)
  • Of primary tumors 64% were mutant for FGFR3, 11% for RAS, 24% for PIK3CA, and 26% for p53. (biomedsearch.com)
  • In patients presenting with NMI-BC grade 3 and MI-BC, 33 and 36% of the primary tumors were mutant. (biomedsearch.com)
  • In patients with low-grade NMI-BC, 88% of the primary tumors carried a mutation and 88% of the recurrences were mutant. (biomedsearch.com)
  • tumorigenesis
  • MUC16 (CA-125) has been shown to play a role in advancing tumorigenesis and tumor proliferation by several different mechanisms. (wikipedia.org)
  • alkaline phosphatase
  • Isoenzymes, which are certain forms of alkaline phosphatase generated by these tumors, enlarges the total volume of alkaline phosphatase levels on experiential studies. (wikipedia.org)
  • Staging
  • Although mammography, ultrasonography, computed tomography, magnetic resonance imaging scans, and tumor marker assays help in the staging and treatment of the cancer, they are usually not definitive diagnostic tests. (wikipedia.org)
  • Staging: some tumor markers are included in the staging procedures for some tumor localizations. (wikipedia.org)
  • cell
  • Double labeling with AE1/AE3 and S100 showed striking localized proximity of the spindle-cell melanocytic and keratinocyte components in some areas of this tumor. (biomedsearch.com)
  • An immunomagnetic epithelial tumor cell enrichment model for minimal residual disease detection of cytokeratin 8+ malignancies. (biomedsearch.com)
  • MUC16 and mesothelin interactions are thought to provide the first step in tumor cell invasion of the peritoneum. (wikipedia.org)
  • EMT suppression allows for E-cadherin to remain and for the cell to not undergo pathological EMT associated with tumor formation. (wikipedia.org)
  • Due to its expression profile, it has been used as a growth marker and targeted for studies in tumor cell growth. (wikipedia.org)
  • M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity. (wikipedia.org)
  • Nuclear
  • Nuclear expression of GATA-3 in breast cancer is considered a marker of luminal cancer in ER+ cancer and luminal androgen responsive cancer in ER-/AR+ tumors. (wikipedia.org)
  • Lymphoma
  • Deletion 6q is not a characteristic marker of nodal lymphoplasmacytic lymphoma. (biomedsearch.com)
  • These results indicate that del(6q) is at least uncommon in nodal LPL, and cannot be employed as a diagnostic marker to identify this type of lymphoma. (biomedsearch.com)
  • characteristics
  • It has been researched that SIM2s acts in mammary gland development and has tumor suppressive characteristics specifically in breast cancer. (wikipedia.org)
  • Expression
  • Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. (biomedsearch.com)
  • Since the progenitor marker neuron-glial-2 (NG2) has been shown to regulate several aspects of GBM progression in experimental systems, we hypothesised that its expression would influence the survival of GBM patients. (biomedsearch.com)
  • cancer
  • Dietary flaxseed has the potential to reduce tumor growth in patients with breast cancer. (aacrjournals.org)
  • There are many different tumor markers, each indicative of a particular disease process, and they are used in oncology to help detect the presence of cancer. (wikipedia.org)
  • GATA-3 was shown to be required for the luminal A type of breast cancer, intertwined in pathways with ERα but also androgen receptor signaling in ER-/AR+ tumors. (wikipedia.org)
  • abundant
  • As the most abundant biological source is women who are presently pregnant, some organizations collect urine from pregnant women to extract hCG for use in fertility treatment. (wikipedia.org)
  • analysis
  • The patient underwent radical cystectomy, and the representative sections of tumor were submitted for immunohistochemical analysis. (biomedsearch.com)
  • growth
  • Flaxseed, the richest source of mammalian lignan precursors, has previously been shown to reduce the growth of tumors in rats. (aacrjournals.org)
  • brain
  • Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. (biomedsearch.com)
  • metastases
  • Placing a given tumor into one of categories depends on well-defined histological features: size, lymphovascular invasion, mitotic counts, Ki-67 labelling index, invasion of adjacent organs, presence of metastases and whether they produce hormones. (wikipedia.org)
  • patients
  • Dietary flaxseed has the potential to reduce tumor growth in patients with breast cancer. (aacrjournals.org)
  • Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. (biomedsearch.com)
  • Since the progenitor marker neuron-glial-2 (NG2) has been shown to regulate several aspects of GBM progression in experimental systems, we hypothesised that its expression would influence the survival of GBM patients. (biomedsearch.com)
  • Citation
  • citation needed] Elevated CEA levels should return to normal after successful surgical removal of the tumor. (wikipedia.org)