Tumor lysate pulsed dendritic tumor vaccination antigen of tumor. Medical search. Frequent questions

Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma: University of Tokyo experience. (nwbio.com)
Large-scale immunomagnetic selection of CD14+ monocytes to generate dendritic cells for cancer immunotherapy: a phase I study. (nwbio.com)
In the first part we talk about immunotherapy and in particular about vaccines, personalized vaccines with dendritic cells, tumor-associated antigen vaccines and the famous vaccine targeted at CytoMegaloVirus (CMV). (glioblastomamultiforme.it)
The mechanisms by which BCG immunotherapy mediates tumor immunity have been widely studied, but they are still not completely understood. (wikipedia.org)
Injection immunotherapy ("intralesional" or "intratumoural") uses mumps, candida, the HPV vaccine or trichophytin antigen injections to treat warts (HPV induced tumours). (wikipedia.org)
Dendritic cells, a type of antigen-presenting cell, are harvested from the person needing the immunotherapy. (wikipedia.org)
These data demonstrate that a transplantation protocol involving only selective tumor-reactive donor T cell families is an effective immunotherapy and results in long-term survival in a mouse model of human MM. The results highlight the need to develop similar ATCT strategies for MM patients that result in enhanced survival without symptoms of GvHD. (biomedcentral.com)
A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma. (ox.ac.uk)
HCC is an attractive target for immunotherapy as evidenced by an active recruitment of tumor-infiltrating lymphocytes that are capable of lysing autologous tumor cells in ex vivo studies. (ox.ac.uk)
These data confirm the presence of tumor-specific TCR within the cancer tissue and suggest the existence of shared epitopes among different patients that might be used as targets for tumor immunotherapy. (oncotarget.com)
To explore the chance of using myeloma cells as the foundation of tumor antigens for immunotherapy myeloma cell lysate-specific CTLs had been generated from sufferers by culturing T cells with autologous DCs pulsed with freeze-thaw lysate from myeloma cells 43. (tech-strategy.org)
Over the last Etretinate few years, immunotherapy has Etretinate demonstrated impressive efficacy for many tumors. (mindunwindart.com)
Conclusions These outcomes recommended that tumor-specific antigens present on exosomes could be shown by DCs produced from unrelated umbilical wire bloodstream to induce tumor particular cytotoxicity which may represent like a book immunotherapy for ovarian tumor. (mdm2-inhibitors.com)
Recent work recommended that tumor-derived exosomes include a spectral range of tumor particular antigens and are likely involved PD0325901 in immunotherapy aimed towards malignant tumors [5]. (mdm2-inhibitors.com)
The Workshop associated with the 27th Annual Meeting of the Society for Immunotherapy of Cancer (SITC), North Bethesda, MD, October 24-25, 2012 focused on targeting the tumor microenvironment as part of an integrative approach to immune-based cancer therapy. (biomedcentral.com)
To support these efforts, the Society for Immunotherapy of Cancer (SITC) held a workshop focused on targeting the tumor microenvironment as part of an integrative approach to immune-based cancer therapy. (biomedcentral.com)
To aid in this effort, SITC provides a venue to facilitate the discussion of current clinical trial results and methodologies, as well as means to collaborate on new initiatives in tumor immunology and cancer immunotherapy with the ultimate goal of improving cancer patient outcomes. (biomedcentral.com)
These results have high potential for immunotherapy against a broad range of tumors. (silverchair.com)
Because of these encouraging results, we applied the same antigenic strategy to TACA-containing glycopeptides because induction of a degenerate T cell response against this class of tumor antigens may be of great advantage in cancer immunotherapy ( 10 - 12 ). (silverchair.com)

Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (nwbio.com)
Immune effector cells such as lymphocytes, macrophages, dendritic cells, natural killer cells, and cytotoxic T lymphocytes work together to defend the body against cancer by targeting abnormal antigens expressed on the surface of tumor cells. (wikipedia.org)
The extraction of G-CSF lymphocytes from the blood and expanding in vitro against a tumour antigen before reinjecting the cells with appropriate stimulatory cytokines. (wikipedia.org)
Upon transfusion into the person, these activated cells present the antigen to the effector lymphocytes (CD4+ helper T cells, cytotoxic CD8+ T cells and B cells). (wikipedia.org)
In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
Objectives Exosomes a kind of membrane vesicles released from tumor cells have already been been shown to be with the capacity of transferring tumor antigens to dendritic cells and activating particular cytotoxic T-lymphocytes. (mdm2-inhibitors.com)
Cytotoxicity of DC-primed lymphocytes in vitro Lymphocytes had been PD0325901 primed by exosomes pulsed-DCs at responder-to-stimulator percentage of 10:1 20 30 respectively. (mdm2-inhibitors.com)
The safety was apt to be linked to the disease fighting capability since vaccinated mice produced particular cytotoxic T lymphocytes the consequences were not observed in SCID mice and immunity was tumor-specific [16]. (mdm2-inhibitors.com)
Probably the most abundant cells in the ascites of our 10 patients were tumor and lymphocytes cells. (mdm2-inhibitors.com)

Vaccines A vaccine is normally a therapy directed at obtaining long-term immunity, or an adaptive immune system response against antigen(s) appealing. (cancer-ecosystem.com)
Systemic immunity, tumor associated immunity, tumor size and survival were examined using a variety of experimental strategies. (bmj.com)
Compositions and methods for enhancing antigen-specific immunity in a subject are provided. (justia.com)
Pharmaceutical compositions including an effective amount of an immuno-stimulatory cardiolipin as an adjuvant in combination with an antigen and methods of use thereof for stimulating protective immunity to the antigen in a subject are provided. (justia.com)
Administration of the combination of the antigen and cardiolipin adjuvant is effective to enhance antigen-specific immunity in a subject to a greater degree than administering to the subject the same amount of the antigen alone. (justia.com)

On leading of particular immunotherapies, cancers vaccines, T cell receptor (TCR) and chimeric antigen receptor (CAR) geneengineered T cells (TCRTs and CARTs) have already been actively examined for HCC. (mindunwindart.com)
CAR, Chimeric antigen receptor. (mindunwindart.com)

Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. (nwbio.com)
Tries at cancers vaccination took many forms, from unaggressive immunization with antitumor antibodies to positively generating an immune system response with autologous/allogeneic tumor lysate, artificial peptides, nude DNA or recombinant viral vectors, aswell as administering immune system cells right to sufferers. (cancer-ecosystem.com)
allogeneic stem cell transplantation and donor lymphocyte infusions with or without donor vaccination using patient-derived idiotype and potential program of donor-derived or hRPB14 patient-derived antigen-specific T-cell infusion within this disease may also be discussed. (tech-strategy.org)
Idiotype-specific proliferative replies were noticed when these T cells had been rechallenged using the autologous however not allogeneic idiotype-pulsed DCs. (tech-strategy.org)
These cell lines proliferated in response to autologous major myeloma cells and DCs pulsed with autologous however not allogeneic tumor lysate and secreted mostly IFN-γ and tumor necrosis aspect (TNF)-α indicating they are YIL 781 type-1 T cells (Th1 and Tc1). (tech-strategy.org)

Maturation and trafficking of monocyte-derived dendritic cells in monkeys: implications for dendritic cell-based vaccines. (nwbio.com)
This is one of the reasons why most vaccines work best when there is a minimum of tumor burden. (glioblastomamultiforme.it)
Lentiviral vector-based dendritic cell vaccines induce protective T cell responses against viral infection and cancer in animal models. (jci.org)
These properties have made lentiviral vectors advantageous for use in dendritic cell (DC) vaccines. (jci.org)
Both peptide and cell-based vaccines possess 193620-69-8 used several strategies: (1) epitopes together with carrier protein to improve immunogenicity, (2) adoptive T-cell transfer and (3) DCs pulsed with peptides. (cancer-ecosystem.com)
To determine if Th17-inducing vaccines are therapeutically effective in OC, we created a murine model of Th17-inducing dendritic cell (DC) (Th17-DC) vaccination generated by stimulating IL-15 while blocking p38 MAPK in bone marrow-derived DCs, followed by antigen pulsing. (bmj.com)
Results Th17-DC vaccines increased Th17 T cells in the tumor microenvironment, reshaped the myeloid microenvironment, and improved mouse survival compared with cDC vaccines. (bmj.com)
Conclusions These findings emphasize using biologically relevant immune modifiers, like Th17-DC vaccines, in OC treatment to reshape the tumor microenvironment and enhance clinical responses to ICB therapy. (bmj.com)
DC vaccines treated with IL-15 and p38 MAPK inhibitor are more effective than standard DC vaccines at generating antigen-specific Th17 T cells in vivo. (bmj.com)
2.?Cancers vaccines Despite the fact that autologous dendritic cells (DCs) pulsed with antigen-undefined tumor cell lysate are also explored to take care of HCC (Palmer et al. (mindunwindart.com)
2009), it's the antigen-defined cancers vaccines that pull the interest of all researchers. (mindunwindart.com)
Particular HCC cancers vaccines derive from HCC-associated antigens, which generally consist of alpha fetoprotein (AFP), glypican 3 (GPC3), NY esophageal squamous cell carcinoma-1 (NY-ESO-1) cancers testis antigen, and individual. (mindunwindart.com)
This shows great potential in mass vaccination, such as the success of the oral polio vaccine and other licensed mucosal vaccines [ 8 ]. (biomedcentral.com)
TACA-containing glycopeptides are appealing cytotoxic T cell (CTL)-based vaccines to prevent or treat cancer because the same sugar moieties are expressed in a variety of tumors, rendering a vaccination strategy applicable in a large population. (silverchair.com)
The other focus of our lab is to find the best setting to integrate vaccines in the standard of care treatment plan for ovarian cancer patients and to understand the immune fitness of cancer patients and correlate it with vaccination. (agora-cancer.ch)
Through the incorporation of novel computational methods for predicting antigen changes to model-informed drug discovery and development, superior vaccines and antibody-based therapeutics or diagnostics can now be more easily designed to mitigate failures. (preprints.org)

To improve the immunogenicity of idiotype proteins we utilized dendritic cells (DCs) as antigen-presenting cells. (tech-strategy.org)

Upon entering affected tissues, classical monocytes can further differentiate into macrophages and monocyte-derived dendritic cells (MoDCs). (frontiersin.org)
Classical "inflammatory" monocytes can give rise to non-classical "patrolling" monocytes or further differentiate into macrophages or monocyte-derived dendritic cells (MoDCs). (frontiersin.org)

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)
These various methods are trying to recognize tumor-rejection antigen(s) and induce an effective immune system response while staying away from autoimmune pathology and stopping immune system evasion. (cancer-ecosystem.com)

After repeated rounds of T-cell excitement with idiotype-pulsed autologous DCs idiotype-specific T-cell lines which contains both Compact disc4+ and Compact disc8+ T cells had been produced and propagated through the peripheral bloodstream mononuclear cells (PBMCs) of myeloma sufferers. (tech-strategy.org)
With a regular 51chromium-release assay our outcomes demonstrated that idiotype-specific CTLs not merely known and lysed autologous idiotype-pulsed DCs but also considerably killed autologous major myeloma cells. (tech-strategy.org)

One technique, T-cell transfer, requires first vaccinating individuals with irradiated autologous tumor cell, accompanied by inguinal lymph-node biopsy to harvest the T cells that react to the vaccine. (cancer-ecosystem.com)
The CTLs got solid cytotoxic activity against autologous tumor lysate-pulsed DCs and major myeloma cells. (tech-strategy.org)

Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
High-grade glioma (HGG) are the most frequent malignant primary brain tumor, which account for 80% of all gliomas in the United States, and are encountered with an annual incidence of 5.26 per 100,000 population, or 17,000 new cases diagnosed per year. (surgicalneurologyint.com)
Malignant brain tumors such as for example glioblastoma (GBM) and brain metastasis have poor prognosis despite standard therapies. (cancer-ecosystem.com)
Established tumors are complex, heterogeneous masses composed of malignant cells admixed with a variety of non-transformed host cells, including stromal cells, endothelial cells, and immune cells. (biomedcentral.com)
This elaborate web of diverse cell types fosters malignant tumor cell interactions with the tumor associated vasculature and fibroblasts as well as a variety of immune cells in support of tumor growth, invasion, and metastasis. (biomedcentral.com)

Some information has been contributed by others to various online brain tumor patient support groups, which I have followed up on, and some is from direct communications with various physicians conducting the treatments that are described. (gotomydoctor.com)

Endogenous synthesis of antigen results in efficient proteolytic peptide processing and presentation of peptide antigen on MHC class I proteins. (jci.org)
Exosomes are released in vitro by various kinds of cells including tumor cell lines [4] and antigen showing cells [1 14 These membrane vesicles possess a different PD0325901 spectral range of proteins weighed against plasma membranes PD0325901 and so are enriched in substances involved with antigen demonstration and proteins included possibly in cell focusing on. (mdm2-inhibitors.com)
Plasmacytoma cells had been shown to launch exosomes in vitro and vaccination with an individual dosage (5 μg) of exosomal proteins shielded Acta2 80% of mice against concern with wild-type tumors. (mdm2-inhibitors.com)

Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)
A mathematical model instantiating these assumptions has recently been developed and has been shown to describe the pattern of tumor growth for melanoma (1). (gotomydoctor.com)

This is an open-label, two-part, phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy of ST101 administered IV in patients with advanced solid tumors. (ucbraid.org)

In this regard, immune-transcriptome analyses of T cell receptor (TCR) Vβ CDR3-size and sequence is being used to characterize alloreactive versus tumor-specific T-cell responses. (biomedcentral.com)
In an attempt to evaluate the immune response of renal cell carcinoma (RCC) patients, tumor lesions and / or blood samples from 12 RCC patients underwent deep T cell receptor (TCR) sequencing. (oncotarget.com)

Prior studies link the presence of IL-17 and Th17 T cells in the tumor microenvironment to improved survival in OC patients. (bmj.com)

However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
The importance of these dynamic cellular interactions in the development of cancer has stimulated strong interest in evaluating components of the tumor microenvironment as targets for cancer therapy. (biomedcentral.com)
Multiple lines of research aim to dissect the tumor microenvironment to gain insight into cancer prognosis and treatment selection, as well as to further understand the mechanisms that drive immune-based tumor rejection. (biomedcentral.com)

These cells are then either pulsed with an antigen or tumour lysate or transfected with a viral vector, causing them to display the antigen. (wikipedia.org)

Interferon treatment has very defined debilitating effects, as do cytokines such as interleukin-2 and tumor necrosis factor, because their modus operandi is essentially to create an inflammatory immune reaction not unlike a severe allergic reaction. (glioblastomamultiforme.it)
Most surface-displayed epitopes induced pro-inflammatory cytokines [tumor necrosis factor alpha (TNF-α and interleukin (IL)-6] and anti-inflammatory cytokines (IL-10) in lipopolysaccharide-induced RAW 264.7, with the highest anti-inflammatory to pro-inflammatory cytokine ratio in the S1-1 and S1-2 groups, followed by that in the S1-3 group. (biomedcentral.com)

These studies demonstrate that many in vivo effects of vaccination (apparent tumor cell death and loss of HER-2 expression) could be replicated in vitro using only the principle Th1 cytokines. (oncotarget.com)

In one of the first small clinical trials (149), nine new high-grade glioma patients received three separate vaccinations two weeks apart. (glioblastomamultiforme.it)
Recently, the treatment of newly diagnosed anaplastic glioma (AG) has changed, particularly in patients with 1p19q codeleted tumors. (surgicalneurologyint.com)
Tumor lysate In response towards the sentiment which the prognosis for high-grade glioma was hopeless, researchers quickly translated a rodent research within a fibrosarcoma model to GBM in human beings.34 Bloom and his group of investigators examined subcutaneous injections of irradiated, non-necrotic tumor to the typical of caution of radical medical procedures and postoperative rays. (cancer-ecosystem.com)
A companion research in anaplastic gliomas, researched regular monthly vaccination with glioma cell lines augmented using the adjuvant Bacillus CalmetteCGurin (BCG), but also didn't show a success advantage.35 Interestingly, this research had a 20% rate of dementia that was postulated could possibly be autoimmune in etiology, although further investigation was limited. (cancer-ecosystem.com)

Since GvT responses involve T-cell recognition of tumor-specific peptides presented by MHC molecules [ 14 ], it may be possible to identify and select donor T cells that provide beneficial GvT responses but minimal GvHD risk. (biomedcentral.com)

Bleumer I, Tiemessen DM, Oosterwijk-Wakka JC, Völler MC, De Weijer K, Mulders PF, Oosterwijk E. Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells. (nwbio.com)

Several approaches relating to the use of entire tumor RNA tumor lysates apoptotic or necrotic particles and fusion are under analysis [4]. (mdm2-inhibitors.com)

The second problem is that the immune system is not an efficient detector of tumor antigens. (glioblastomamultiforme.it)
The larger the tumor, the stronger its defense mechanisms are to counteract detection by the immune system. (glioblastomamultiforme.it)
The heterokaryons produced by cancer-DC fusion cells combine the equipment needed for immune system stimulation YIL 781 with display of a big repertoire of antigens. (tech-strategy.org)
Dendritic cell as sentinel of the immune system plays an irreplaceable role. (medsci.org)
Dicussion Preferably immunotherapeutic strategies targeted at immunizing the sponsor can elicit T-cell-mediated immune system responses against a wide repertoire of tumor particular antigens. (mdm2-inhibitors.com)
The prevention of immune cell access into the tumor, the accumulation of inhibitory FoxP3 + regulatory T cells (Treg) and/or myeloid-derived suppressor cells (MDSCs), the activation of negative immunoregulatory pathways, and the dysregulation of effector T cells are all mechanisms by which tumors evade the host immune system. (biomedcentral.com)

The current approaches for DC-based vaccination are mainly based on antigen loading on in vitro-generated DCs from monocytes or CD34+ cells, activating them with different TLR ligands, cytokine combinations, and injecting them back to the patients. (wikipedia.org)
In the current study we show that designer glycopeptides containing the Thomsen-Freidenreich (TF) antigen (β-Gal-[1→3]-α-GalNAc- O -serine) are immunogenic in vivo and generate TF-specific CTL capable of recognizing a variety of tumor cells in vitro including a MUC1-expressing tumor. (silverchair.com)

Desk 2 Natural red absorbance worth (A worth) of ovarian tumor cells from ascites and cytotoxicity of effector cells in various organizations at responder-to-stimulator percentage of 30:1(suggest ± SD). (mdm2-inhibitors.com)

Fusions with older in comparison with immature DCs induced higher degrees of T-cell proliferation and activation as evaluated by intracellular IFN-γ appearance and more powerful cytotoxic T-cell activity against the tumor cells. (tech-strategy.org)
HER-3 also plays a critical role in tumor cell growth and proliferation in tumors driven by HER-2 over-expression [ 6 , 7 ]. (oncotarget.com)

UNLABELLED: This is a phase II clinical trial investigating the safety and efficacy of intravenous vaccination with mature autologous dendritic cells (DCs) pulsed ex vivo with a liver tumor cell line lysate (HepG2) in patients with advanced hepatocellular carcinoma (HCC). (ox.ac.uk)
In this study, we tested whether preventative and therapeutic vaccination could be achieved by direct injection of antigen-expressing lentiviral vector, obviating the need for ex vivo transduction of dendritic cells. (jci.org)
His research program spans a range from basic studies in molecular cancer genetics and tumor immunology to translational clinical cancer research testing novel immunotherapeutic strategies and targeted compounds in vivo for the treatment of gynecologic malignancies. (yale.edu)

Myeloma plasma cells and myeloma-specific T cells Myeloma tumor cells may include a large number of tumor antigens that may stimulate an elevated repertoire of YIL 781 anti-tumor T cells and result in an induction of more powerful antimyeloma replies. (tech-strategy.org)
In murine plasmacytoma versions vaccination with DCs fused with mouse 4TOO plasmacytoma cells 44 or J558 myeloma YIL 781 cells 45 was connected with induction of anti-tumor humoral and CTL replies. (tech-strategy.org)

Recently, stem cells are being engineered to carry therapeutic reagents to target tumor sites. (bmrat.org)

This binding inhibits cell lysis, nevertheless, antibodies to PD-1 or PD-L1 prevents this binding and augments tumor eradication. (cancer-ecosystem.com)
Immunization using the fusion cells secured mice against tumor problem and expanded the success of tumor-established mice without eradication from the tumor cells. (tech-strategy.org)

DCs are the most potent antigen-presenting cells, with the capacity to take up, process, and present tumor antigens to T cells and stimulate an immune response, thus providing a rational platform for vaccine development. (ox.ac.uk)
Dendritic cells (DCs) treated with IL-15 and p38 MAPK inhibitor stimulate IL-17 release from T cells in culture. (bmj.com)

The World Health Organization (WHO) classification of gliomas is used to define the type and grade of tumor, but the prognosis and response to treatment may vary among tumors even in the same subtype of tumor. (surgicalneurologyint.com)
and (4) the tumor Immunoscore as a new indicator of prognosis, and predictive marker of response to cancer therapy. (biomedcentral.com)

Monocytes and their derivatives, including macrophages and dendritic cells, play diverse roles in the response to fungal pathogens. (frontiersin.org)
Monocytes can also present fungal antigens to elicit adaptive immune responses. (frontiersin.org)
Monocytes can develop from either a granulocyte-monocyte progenitor (GMP) or a monocyte-dendritic cell progenitor (MDP). (frontiersin.org)

Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA. (nwbio.com)

Upon i.m. injection of DNA vectors expressing Nef mut -derivatives, nanovesicles containing antigens fused with Nef mut are released by muscle cells, can freely circulate into the body, and can be internalized by antigen-presenting cells (APCs). (nature.com)

Methods to improve the detection of tumor antigens are now the subject of intense research for various types of cancer. (glioblastomamultiforme.it)
Methods ID8 tumor cells were injected intraperitoneally into mice. (bmj.com)

Vaccination by direct injection of lentiviral vector was more effective in sterile alpha motif and HD-domain containing protein 1-knockout (SAMHD1-knockout) mice, suggesting that lentiviral vectors containing Vpx, a lentiviral protein that increases the efficiency of dendritic cell transduction by inducing the degradation of SAMHD1, would be an effective strategy for the treatment of chronic disease in humans. (jci.org)

Upon the detection of either type of the antigen preparation, the lowest concentration of the antigen detectable in buffer with pH 5.1 has been found to be approximately equal, amounting to ~10 -14 M. This value has been found to be similar upon the use of either type of molecular probes. (preprints.org)
Many of these factors stem from the location of the epitope that can affect accessibility of the antibody to the epitope at a cellular or molecular level, direct inhibition of target antigen activity, conservation of function despite escape mutations, and even non-competitive inhibition sites. (preprints.org)

This initiates a cytotoxic response against tumour cells expressing the antigen (against which the adaptive response has now been primed). (wikipedia.org)
Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)

Injection of a lentiviral vector encoding an MHC class I-restricted T cell epitope of lymphocytic choriomeningitis virus (LCMV) and CD40 ligand induced an antigen-specific cytolytic CD8 + T lymphocyte response that protected the mice from infection. (jci.org)
Three weeks after the second immunization, virus replication was reduced in mice best responding to vaccination by more than 3-logs compared to the control group. (nature.com)
Thus, the oral administration of SARS-CoV-2 antigens into mice induced significant humoral and mucosal immune responses. (biomedcentral.com)

The aim is to improve whole tumor lysate vaccination approaches and other personalized cancer vaccine approaches by improving the dendritic cell platform and by choosing the most immunogenic antigen with the most practical preparation to be translated rapidly to the clinic. (agora-cancer.ch)

These results are consistent with the notion that IFN-γ and TNF-α work in concert to mediate many biological effects of therapeutic vaccination through the induction of a caspase 3-associated cellular death mechanism. (oncotarget.com)

Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses. (nwbio.com)
Glioblastoma is the most prevalent and aggressive primary brain tumour for which total tumour lysate-pulsed dendritic cell vaccination is currently under clinical evaluation. (amsterdamumc.org)

Much of the curative potential of allografts is attributed to the graft-versus-tumor (GvT) response that aims to destroy residual tumor cells that persist after induction therapy and ASCT [ 5 ]. (biomedcentral.com)
Also available now are three other treatments that have FDA approval for tumors that have recurred or have progressed after initial treatment: Avastin, Gliadel, and an electrical field therapy named Novocure TTF. (gotomydoctor.com)
Radiation therapy uses high-energy x-rays to kill tumor cells. (ucbraid.org)
It also tests whether combination of selinexor and standard radiation therapy works to shrink tumors in this patient population. (ucbraid.org)

Alternatively, the DCs are transduced with a viral vector that expresses the antigen. (jci.org)

Thirty-five patients with advanced HCC and not suitable for radical or loco-regional therapies received a maximum of six DC vaccinations each at 3-week intervals. (ox.ac.uk)

This growth factor also causes the mixture of cancer and dendritic cells to expand. (glioblastomamultiforme.it)
This use of dendritic cells has been applied to different types of cancer. (glioblastomamultiforme.it)

Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
Surprisingly, however, glioblastoma EVs lack glycans that could bind Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN, CD209), a receptor that mediates uptake and induction of CD4+ and CD8+ T cell activation. (amsterdamumc.org)
In several cases there was induction of T cell responses to the vaccine and/or AFP following vaccination. (ox.ac.uk)

CONCLUSION: Autologous DC vaccination in patients with HCC is safe and well tolerated with evidence of antitumor efficacy assessed radiologically and serologically, with generation of antigen-specific immune responses in some cases. (ox.ac.uk)
ICB had limited efficacy in OC, but Th17-inducing DC vaccination sensitized it to anti-PD-1 ICB, resulting in durable progression-free survival by overcoming IL-10-mediated resistance. (bmj.com)

Robust T cell infiltration was detected in tumor samples and median survival was 455 days (compared with 257 days in the control population). (glioblastomamultiforme.it)
These data highlight the possibility that tumor-specific ATCT may lead to long-term disease-free survival without GvHD in patients with MM. (biomedcentral.com)

Anatomy17

Organisms10

Diseases69

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes40

Disciplines and Occupations1

Information Science4

Health Care10

Immunotherapy19

Lymphocytes9

Immunity5

Chimeric Antigen Receptor2

Allogeneic5

Vaccines16

Utilized dendritic cells1

Monocyte-derived dendritic cells2

Induce2

Idiotype-pulsed2

Autologous tumor2

Malignant5

Brain tumor1

Proteins3

Melanoma2

Solid tumors1

Cell receptor2

Cells in the tumor1

Microenvironment3

Transfected with a viral vector1

Necrosis factor2

Cytokines1

Glioma4

Peptides1

Renal cell carc1

Apoptotic1

Immune system6

Vitro2

Effector cells1

Proliferation2

Vivo3

Anti-tumor2

Target tumor1

Eradication2

Stimulate2

Prognosis2

Monocytes3

Recombinant1

APCs1

Methods2

Vectors1

Molecular2

Adaptive2

Mice3

Immunogenic1

Therapeutic vaccination1

Clinical2

Therapy4

Viral1

Therapies1

Cancer2

Induction3

Efficacy2

Survival2