• Unlike nearly all syngeneic mouse tumors, the JC1-2-shaped tumors resembled 'swollen tumors' because of the abundancy of immune system cells in Naringin (Naringoside) the tumor microenvironment. (mycareerpeer.com)
  • Orthotopic and heterotopic mouse tumor types of JC1-2 cells had been established and even more intense immune system responses had been seen in the microenvironment from the orthotopic model. (mycareerpeer.com)
  • Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. (nature.com)
  • Additionally, characterization of the tumor microenvironment such as interactions with immune cells remain largely unknown. (springer.com)
  • Apart from CSCs, there are a myriad of factors and interactions between various cell types and the tumor microenvironment (TME) that ultimately affect CCA progression. (springer.com)
  • Furthermore, the Food & Drug Administration (FDA)-approved mIDH1 inhibitor ivosidenib (AG-120) dramatically inhibited tumor growth in preclinical models of pancreatic cancer, highlighting this approach as a potential therapeutic strategy against wild-type IDH1 cancers. (nature.com)
  • Glioma, the vast majority of intracranial malignant tumors, is characterized by rapid proliferation and aggressive invasion [ 1 ]. (jcancer.org)
  • LOH is normally connected with tumor suppressor genes (such as for example p53), which inhibit the event of malignant tumors when both alleles can be found. (mycareerpeer.com)
  • HU-336 is highly effective against tumor xenografts in nude mice. (wikipedia.org)
  • In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • The potential anti-angiogenic effect of formononetin was examined in nude mouse xenografts. (spandidos-publications.com)
  • In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • It is from these studies that novel techniques seen to reduce the size of prostate tumor xenografts have had recent success using drugs injected into mice (Greco et al. (experts.com)
  • Finally, the inhibitory effect of the combined chidamide and bortezomib treatment on MGC-803 cells was verified in vivo through tumor formation experiments in nude mice. (dovepress.com)
  • The effects of the low-dose chidamide and bortezomib combination reduced the growth on gastric cancer in vivo were investigated by using a subcutaneous tumor mouse model. (dovepress.com)
  • Studies reported that caffeic acid might promote apoptosis in MG-63 osteosarcoma cells, however, the effect of caffeic acid treatment in preventing tumour mass formation has not been well elucidated, especially in MG-63 cells-induced nude mice in vivo . (inabj.org)
  • We used a prototype of an in vivo BT-MRI apparatus to visualise organs and tumors and to analyse tumor progression in nude mouse xenograft models of human testicular germ cell tumor and colon carcinoma. (biomedcentral.com)
  • Subsequently, we used a model of neuroinvasion in nude mice to assess the effect of NGF in vivo on tumor nerve invasion as well as on nociceptive transmission. (hindawi.com)
  • As nonsulfated gastrin derivatives were shown to be more suitable for tumor targeting by virtue of their CCK-2 receptor selectivity, high affinity, and favorable in vivo profile ( 20 ), Behr et al. (snmjournals.org)
  • and (b) significantly reduces tumour size in vivo . (nature.com)
  • Using a mouse model of ependymoma-a chemoresistant brain tumor-we combined multicell high-throughput screening (HTS), kinome-wide binding assays, and in vivo efficacy studies, to identify potential treatments with predicted toxicity against neural stem cells (NSC). (nih.gov)
  • Moreover, in vivo studies confirm that the CTAC@MSNs-HSA are able to induce cancer cell death and efficiently inhibit tumor growth. (rsc.org)
  • However, in some cases final necropsy revealed the existence of additional, deeper located tumors that had not been detected in vivo by their mPlum signal. (nih.gov)
  • Consistently, only the weights of the tumors that were detected in vivo based on their mPlum signal correlated with FI. (nih.gov)
  • The anti-tumour action of the two antibodies prevents the establishment of DU145 cell tumour in nude mice in vivo. (ias.ac.in)
  • For in-vivo evaluation, simultaneous triple-isotope and multi-animal studies were performed on mice. (unav.edu)
  • Then, if the compounds we identified had the ability to kill the neuroblastoma tumor cells both in vitro and in vivo, the second goal was to develop new drugs to treat the patients with aggressive neuroblastoma using the structural information of the chemical compounds we identified. (worldcommunitygrid.org)
  • 1 These tumors are difficult to find because their early symptoms are not obvious, and most of these tumors would have already progressed to the late stage with lymphatic or distal metastasis by the time they are discovered. (dovepress.com)
  • Infiltration versus metastasis is one of the most characteristic biological properties of tumors [ 5 ]. (hindawi.com)
  • Generally, it is believed that there are four main pathways between tumor invasion and metastasis, including local invasion, blood, lymphatic, and seeding metastasis [ 6 ]. (hindawi.com)
  • In addition to these four pathways, tumors can undergo infiltration around nerve fibers and metastasis along nerves, that is, perineural invasion (PNI), which refers to the phenomenon of perineural invasion by tumor cells filling the perineurial space, wrapping around nerves in a continuous concentric sheath-like pattern, infiltration, and metastasis of extension along nerves around nerve fibers or into perineurium within the perineurium [ 7 ]. (hindawi.com)
  • Angiogenesis is essential in the process of carcinogenesis to facilitate tumor progression and metastasis. (spandidos-publications.com)
  • TAK-285 was examined in a model of breast cancer brain metastasis using direct intracranial injection of BT-474-derived luciferase-expressing cells and showed greater inhibition of brain tumor growth compared to animals treated with lapatinib. (jcancer.org)
  • In addition, lung metastasis was observed in nude mice in T-16HBE-C1, 3 and 4 groups.In vitrocell migration assay results indicated that T-16HBE-C2?5 cells showed much lower migration capabilities than 16HBE cells. (eurekamag.com)
  • Therefore, inhibiting EGFR alone may not be sufficient for substantial inhibition of all tumor cells, highlighting the need for multipoint intervention. (aacrjournals.org)
  • However, in recent years, there has been increasing evidence that metformin exerts its anticancer effects through the inhibition of oxidative phosphorylation (OXPHOS) of tumor cell mitochondria, and metabolic pathways based on metformin targeting have only recently become the focus of intensive research. (spandidos-publications.com)
  • Although the mechanism of the effect of the emitted qi still remains unknown, the results of the present research reveals the necessity as well as the possibility of further investigating the inhibition of tumors and its mechanism. (qigonginstitute.org)
  • Our findings demonstrate that PKM2 promotes tumor progression and galectin-9-mediated immunosuppression via NF-κB signaling inhibition in HNSCC, which bridges metabolism and immunosuppression. (researchsquare.com)
  • Therapeutic approaches that target the metabolism of tumor cells have been a popular research topic in recent years. (spandidos-publications.com)
  • However, the mitochondrial oxidative phosphorylation (OXPHOS) pathway in tumor cells has also been implicated in lung cancer metabolism. (spandidos-publications.com)
  • Given the vast differences in metabolism between healthy and tumor cells, there is hope that selective targeting of tumor metabolism may be achieved while limiting toxicity to healthy tissue. (spandidos-publications.com)
  • However, how metabolism reprogramming promotes tumor progression and immune escape remains unclear. (researchsquare.com)
  • This work reveals the possible relationship between intestinal flora, metabolism and immunity and RA in mice, which will provide new therapeutic strategies for RA. (bvsalud.org)
  • Therefore, the density of microvessels in tumor tissues has become an important key to the smooth growth of tumors. (ganoherb.com)
  • In other words, the combination of GLTs and GEF can block more tumor tissues from obtaining nutrients and make tumors more difficult to grow. (ganoherb.com)
  • After injection in mice they displayed rapid, high, and specific localization in the CCK-2/gastrin-R-expressing tissues (stomach and AR4-2J tumor) and were excreted from the body via the kidneys in the form of hydrophilic metabolites. (snmjournals.org)
  • The tumor size and the number of proliferating cells were reduced in the tumor tissues obtained from the formononetin-treated group. (spandidos-publications.com)
  • Traditionally, CSCs are identified through a combination of surface markers, however, there is a lack of consensus among the scientific community, especially as these combinations appear to be specific to the corresponding tissues and tumors. (springer.com)
  • Nude mouse xenograft models of different human tumors were used to test the suitability of the new BT-MRI system for visualisation of organs and tumors and for quantification of tumor progression. (biomedcentral.com)
  • Monitoring of tumor progression evaluated by pixel extension analyses based on NMR images correlated with increasing tumor volume calculated by calliper measurement. (biomedcentral.com)
  • BT-MRI provides satisfactory image quality to visualize organs and tumors and to monitor tumor progression and structure in mouse models. (biomedcentral.com)
  • Because of the different tumorigenicities in nude and C57BL/6 mice, the disease fighting capability might play a significant role in inoculated JC1 tumor progression. (mycareerpeer.com)
  • Pyruvate kinase M2 (PKM2) is a key rate-limiting enzyme in glycolysis, and which plays a critical role in tumor progression in various malignancies. (researchsquare.com)
  • However, how PKM2 promotes tumor progression and its mechanism remain obscure. (researchsquare.com)
  • In addition, the researchers also observed in the tumor tissue sections of each group of mice that under the combined action of GLTs and GEF, the secretion of protein (Bax) that promotes cancer cell apoptosis will significantly increase while the secretion of protein (Bcl-2) that inhibits apoptosis of cancer cells will decrease. (ganoherb.com)
  • MG-63 cells were pre-treated with 0, 1, or 10 µg/mL caffeic acid, and 6 hours after pre-treatment, MG-63 cells were injected into subcutaneous space of mice to induce osteosarcoma. (inabj.org)
  • Another model was also created by subcutaneously injecting MG-63 cells to the back of mice, and after 48 days, the visible tumour mass was injected intra-tumour with 0 or 10 µg/mL caffeic acid every 7 days for 6 times. (inabj.org)
  • In pre-treated MG-63 cells-induced mice, volumes of the mass decreased in reverse with the dose of caffeic acid given. (inabj.org)
  • Results of caffeic acid pre-treatment and caffeic acid treatment in tumour mass of mice show that caffeic acid is able to inhibit the MG-63 cells formation. (inabj.org)
  • Splenocytes had been isolated from C57BL/6 mice and co-cultured with JC1-2 cells to verify the responsiveness Naringin (Naringoside) from the interferon (IFN)- pathway in the JC1-2 cell range. (mycareerpeer.com)
  • Herein, we also demonstrate that compounds developed to target mutant IDH1 can be repurposed as wild-type IDH1 inhibitors, because these drugs surprisingly become potent inhibitors of wtIDH1 in cancer cells under conditions present in tumors: specifically, we found that wtIDH1 is critical for PDAC cell survival under low-glucose conditions, and allosteric IDH inhibitors effectively block wtIDH1 activity under low magnesium. (nature.com)
  • Certain metabolic alterations, also referred to as metabolic reprogramming, are commonly observed in tumor cells and are proposed to be hallmarks of cancer ( 8 ). (spandidos-publications.com)
  • In the first experiment, a qigong master treated the poorly differentiated nasopharyngeal squamous cell carcinoma cell line (CNE-2) with his emitted qi, followed by the innoculation of the treated cell (qigong group) and the untreated cells (control group) into 16 female nude mice (NC-Z strain mice). (qigonginstitute.org)
  • The results showed that the tumor formation of the treated cells was inhibited by an impressive rate of 100% (3/3). (qigonginstitute.org)
  • A pathological examination further confirmed that there were no tumo cells in the inoculating site of the qigong group, whereas poorly differentiated squamous cell carcinomas were observed in tumor of the control group. (qigonginstitute.org)
  • Cancer stem cells (CSCs) represent a small subset of the tumor population and reside at the apex of the hierarchy [ 9 ]. (springer.com)
  • Further, nude mice were injected with TCE-transformed cells. (cdc.gov)
  • All the mice injected with transformed cells developed tumors indicating the tumorigenic potential of TCE. (cdc.gov)
  • DNA from transformed cells were subjected to differential PCR to detect changes in gene copy number and gene expression of six protooncogenes (K-ras, c-fos, c-jun, c-myc, c-sis, erb-B2) and two tumor suppressor genes (p53, p16). (cdc.gov)
  • Mice were inoculated with PC-3 prostate cancer cells followed by a 7-week tumor development. (umd.edu)
  • After xenograft, dietary selenium status does not affect levels of CD4 and CD8 T cells in adult nude mice in Experiment 1, while high selenium resulted in significant decrease in CD4 T cells in young nude mice in Experiment 2. (umd.edu)
  • 2003). These so-called nude mice have a marked ability to engraft many different types of tumor cells from other animals, including humans. (experts.com)
  • T-16HBE-C1?5 cells can form tumors subcutaneously in nude mice. (eurekamag.com)
  • T-16HBE-C1?5 cells all formed tumors subcutaneously in nude mice. (eurekamag.com)
  • We are currently analyzing the molecular pathway by which those compounds kill the tumor cells. (worldcommunitygrid.org)
  • The balance of immune cells in the intestine of RA mice was significantly disrupted, with an overall decrease in immune cells. (bvsalud.org)
  • Studies on the anti-tumour, anti-bacterial, and wound-healing properties of dragon's blood. (rain-tree.com)
  • Breast cancer is one of the most common primary tumors to develop associated brain metastases ( 1 , 2 ), and while recent progress in cancer therapy has improved control of primary breast tumors, methods to effectively treat brain metastases from breast cancer remain inadequate. (jcancer.org)
  • In mouse and rat xenograft tumor models, TAK-285 showed antitumor activity against cancers that expressed HER2 or EGFR. (jcancer.org)
  • Here we investigated whether quantification of a xenograft tumor intrinsic fluorescence signal can be used to evaluate tumor growth and response to chemotherapy. (nih.gov)
  • Applying subcutaneous tumor models in different experimental designs, specific correlations between measured total fluorescence intensity (FI) and the tumor volume (V) could be established. (nih.gov)
  • In this study, we examined the therapeutic potential of a cold plasma jet in cancer cell lines and tumours, focusing on selective tumour cell eradication capabilities and signalling pathway deregulation. (nature.com)
  • GLTs and GEF can inhibit the growth of lung adenocarcinoma tumors, but the combination of the two has a better effect (Figure 1~3). (ganoherb.com)
  • Meanwhile, the intra-tumour treatment of 10 µg/mL caffeic acid, even though not significant, was able to inhibit tumour mass formation. (inabj.org)
  • It has also been shown that metformin and phenformin inhibit tumor growth by disrupting mitochondrial complex. (rsc.org)
  • These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
  • The vascular endothelial growth factor (VEGF) is a well characterized angiogenic factor known to stimulate angiogenesis within a tumor ( 1 ). (spandidos-publications.com)
  • Simple Summary New blood vessel formation (angiogenesis) has a crucial role in tumour growth and spread. (unav.edu)
  • developed [ 111 In-DTPA 0 ]minigastrin showing high uptake in stomach and tumor lesions in metastatic MTC patients ( 20 ). (snmjournals.org)
  • In 1938, Cushing and Eisenhardt first used the term "meningioma" to describe these lesions and introduced it as a separate category of extraparenchymal tumors. (medscape.com)
  • on the other hand, the combination of GLTs and GEF can best maintain the bodyweight of lung adenocarcinoma mice ── closest to that of normal mice (normal control group) (Figure 5). (ganoherb.com)
  • But in the control group of the first experiment, tumors metastasized to the lung in mouse 2. (qigonginstitute.org)
  • membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis. (cancerindex.org)
  • Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. (cancerindex.org)
  • This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. (cancerindex.org)
  • Sphenoid wing meningiomas are categorized as lateral, middle, or medial (clinoidal), depending on the origin of the tumor along the sphenoid ridge. (medscape.com)
  • Rutin exerts antitumor effects on nude mice bearing SW480 tumor. (rain-tree.com)
  • TAK-285 was as effective as lapatinib in antitumor activity in a mouse subcutaneous BT-474 breast cancer xenograft model. (jcancer.org)
  • These qualities could be confirmed for [ 99m Tc]Demogastrin 2, which provided excellent delineation of tumor deposits in a first patient with metastatic medullary thyroid cancer. (snmjournals.org)
  • The advent of radiolabeled somatostatin analogs in the targeted imaging and radionuclide therapy of tumors overexpressing somatostatin receptors has paved the way for other radiopeptides to target alternative cancer-associated peptide receptor systems ( 1 - 4 ). (snmjournals.org)
  • The development of cold plasma tumour ablation has the potential of shifting the current paradigm of cancer treatment and enabling the transformation of cancer treatment technologies by utilisation of another state of matter. (nature.com)
  • 2 Thus, simple surgical treatment cannot aid in full eradication of these tumors. (dovepress.com)
  • Having an immunodeficient research subject is a valuable asset since it removes the single most important degree of freedom: tumor rejection. (experts.com)
  • In conclusion, as long as tumors are visualized by their fluorescence signal the FI can be used to evaluate tumor burden. (nih.gov)
  • Thus, the best available treatments against PDAC (that is, chemotherapy) are less effective under tumor-associated conditions. (nature.com)
  • In a model of visceral growing mPlum tumors, measurements of FI could be used to follow growth and response to chemotherapy. (nih.gov)
  • The promising characteristics of [ 99m Tc]Demogastrin 1-3 both in vitro and in animal models illustrate their suitability for CCK-2/gastrin-R-targeted tumor imaging. (snmjournals.org)
  • Both LCRF-0004 and BMS-777607 demonstrated significant anti-tumor efficacy in vitro , however BMS-777607 was far superior to LCRF-0004. (frontiersin.org)
  • Furthermore, more intense immune system responses had been seen in the orthotopic mouse model than in the heterotopic model. (mycareerpeer.com)
  • A continuous monitoring of the whole tumor burden of individuals in orthotopic tumor models is a desirable aim and requires non-invasive imaging methods. (nih.gov)
  • The researchers first implanted human alveolar adenocarcinoma cell lines (A549 cell lines) under the skin of mice with compromised immune systems. (ganoherb.com)
  • Chemical substance induction was utilized to determine the tumorigenicity-enhanced cell range, JC1-2, that may type syngeneic tumors in immunocompetent C57BL/6 mice. (mycareerpeer.com)
  • Following the double-blind method, we carried out two experiments by using cell cultures and nude mice. (qigonginstitute.org)
  • Taken together, there is an opposing role of excessive selenium on tumor xenograft development in adult and young nude mice carrying differential T cell profiles. (umd.edu)
  • Stably fluorescence protein (FP) expressing cell clones of colorectal carcinoma and germ cell tumor lines were generated by lentiviral transduction using the FPs eGFP, dsRed2, TurboFP635, and mPlum. (nih.gov)
  • Histopathological changes in the tumors indicated nests growth, high nuclear-cytoplasmic ratios, coarse and clumped chromatin, numerous and distinctly atypical mitoses, cell necrosis and surrounding normal adipose, muscle and connective tissue immersed. (eurekamag.com)
  • The product of a hybrid cell clone, P 3 W 80 , obtained as ascites fluid from mouse peritoneal cavity had high titres of anti-human chorionic gonadotropin antibodies e.g. 30 to 40% binding of 125 I-human chorionic gonadotropin at 10 7 dilution in a radioimmunoassay. (ias.ac.in)
  • Its primary goal was to identify small chemical compounds which target the particular sites of the proteins important in regulating the tumor cell growth and aggressiveness. (worldcommunitygrid.org)
  • S. Choofong, P. Cloutier, L. Sanche, J. R. Wagner "Increased radio-sensitivity of colorectal tumor with intra-tumoral injection of low dose of gold nanoparticles. (usherbrooke.ca)
  • Two beats one: osteosarcoma therapy with light-activated and chemo-releasing keratin nanoformulation in a preclinical mouse model. (inabj.org)
  • To observe the effects of Asini Corii Colla, turtle carapace glue, and other drugs on the intestinal flora of nude mice with uterine fibroids model, so as to provide evidence for the clinical application of drugs. (hindawi.com)
  • the decrease in the relative abundance of Firmicutes and the increase in the relative abundance of Bacteroidetes were important structural changes of intestinal flora in nude mice at 4 weeks after administration. (hindawi.com)
  • Therefore, on the basis of previous experiments, this study conducted biodiversity sequencing through 16SrRNA to observe the structural changes of intestinal flora of the nude mice with uterine fibroids model under the action of donkey-hide gelatin, turtle shell glue, and other traditional Chinese medicines, providing strong evidence for traditional Chinese medicine to regulate the intestinal microecology of nude mice with uterine fibroids. (hindawi.com)
  • Moreover, we systematically explored how the imbalance of intestinal flora changed the intestinal immune status through its metabolites in RA mice. (bvsalud.org)
  • Our results showed that the intestinal flora of RA mice changed significantly, and the bacteria producing short-chain fatty acids (SCFAs), indole classes and secondary bile acids were significantly reduced. (bvsalud.org)
  • Tumour proliferation and hypoxic status were evaluated using F-18-fluoro-3 '-deoxy-3 '-L-fluorothymidine (FLT)- and F-18-fluoromisonidazole (FMISO)-positron emission tomography (PET) at baseline, and during C1 and C5. (unav.edu)
  • Abstract -- In order to determine a mouse's dose accurately and prior to engaging in live mouse radiobiological research , a tissue-equivalent tumor-bearing phantom mouse was constructed and bored to accommodate detectors. (experts.com)
  • The implications of this finding overshadowed the importance of mitochondria for tumor growth for a long time. (spandidos-publications.com)
  • Xenografting is a common technique used by radiobiologists to test the characteristics of disease growth, inhibiting drugs, and tumor responses to drugs and radiation by the injection of tumors and drugs into nude mice. (experts.com)
  • 2010). Radiobiologists have valued this animal model for sustained grafted tumor growth, which permits fractionation considerations in therapeutic models, even for radiation therapy (Allam et al. (experts.com)
  • In this study, we used a combination of imaging techniques and VEGF marker levels to show that bevacizumab caused structural and functional changes in the blood vessels of breast tumours and substantially slowed tumour growth. (unav.edu)
  • We then selected the 2 chemicals with the lowest IC 50 values, and found that they significantly suppressed the zenografted tumor growth in nude mice. (worldcommunitygrid.org)
  • Two different growing patterns of sphenoid wing meningioma have been described: meningioma en masse, forming a nodular space-occupying lesion, and meningioma en plaque, which is flat and demonstrates a carpet-like growth pattern. (medscape.com)
  • A number of therapeutic options are available for patients with prostate carcinoma till the time that the tumour is hormone dependent. (ias.ac.in)
  • The aim of this study was to evaluate 3 new 99m Tc-labeled minigastrin analogs modified with open chain tetraamines at the N-terminus for their suitability in the CCK-2/gastrin-R-targeted imaging of tumors (CCK-2/gastrin-R = cholecystokinin subtype 2/gastrin receptor). (snmjournals.org)
  • 0.001), independent of tumour subtype. (unav.edu)
  • The specific pathogenesis of uterine fibroids has not been fully defined, but it is generally believed that high levels of estrogen and progesterone can promote the formation and development of uterine fibroids, that is, uterine fibroids are considered sex hormone-dependent tumors [ 2 ]. (hindawi.com)
  • In view of the above, several investigators have been involved in the development of radiolabeled gastrin/CCK analogs for targeted diagnostic imaging and radionuclide therapy of CCK-2/gastrin-R-expressing tumors. (snmjournals.org)
  • Photoacoustic (PA) imaging has shown tremendous promise for imaging tumor vasculature and its function at deeper penetration depths without the use of exogenous contrast agents. (mdpi.com)
  • In this study, we evaluated the capability of a Light-Emitting Diode (LED)-based PA and ultrasound (US) imaging system for monitoring heterogeneous microvasculature in tumors (up to 10 mm in depth) and quantitatively compared the PA images with gold standard histology images. (mdpi.com)
  • The performance of the SPECT was evaluated for two collimators dedicated for mouse (UHS-M) and rat imaging (UHR-RM) in terms of sensitivity, energy resolution, uniformity and spatial resolution. (unav.edu)
  • In mice, simultaneous multi-isotope imaging provided the separate distribution of 3 tracers and image quality of the multi-mouse bone scan was adequate. (unav.edu)
  • However, there are no validated methods for predicting which patients will respond to bevacizumab, although some have investigated whether a response can be predicted by using scanning (imaging) techniques that study tumour blood vessels or by using the levels of VEGF markers before treatment. (unav.edu)
  • In positron emission tomography (PET)/CT, the high rate of glycolysis in NSCLC is reflected by the high uptake of 18F-fluorodeoxyglucose at the corresponding tumor sites ( 12 ). (spandidos-publications.com)
  • In addition, mitochondria have also been proved to be essential for tumor generation and development. (rsc.org)
  • Comparisons were made among four different types of radiation detectors, each inserted into the mouse phantom for radiation measurement under a 6 MV linear accelerator beam. (experts.com)
  • Still, radiation control branches and inspectors general have provided approval for dual use with immunodepressed nude mice when infectious disease control measures are properly in place. (experts.com)
  • [ 5 ] and 34-36.4% of all primary brain tumors, making meningiomas the most common primary brain tumors. (medscape.com)
  • Sphenoid wing meningiomas also are known as "orbitosphenoid meningiomas," "meningiomas en plaque of the sphenoid wing," and "sphenoid wing meningiomas with osseous involvement. (medscape.com)
  • 10-12 Noticeably, cationic surfactant is more extensively used in tumor treatment than other types of surfactants, such as anionic and nonionic surfactant. (rsc.org)
  • Histopathology of the tumor may determine the postoperative treatment course for patients. (medscape.com)
  • As a total result, a trusted mouse model can be urgently necessary for tumor Naringin (Naringoside) immunology research (14). (mycareerpeer.com)
  • Then, the model nude mice were fed ejiao, turtle carapace glue, and other corresponding drugs. (hindawi.com)
  • Before administration, 2 weeks after administration, and 4 weeks after administration, the feces of the model nude mice were taken respectively, subpacked into labeled cryotubes, and stored at −80°C. All samples were sent for gene sequencing after completion. (hindawi.com)
  • The orbital involvement of the tumor causes significant proptosis of the affected eye. (medscape.com)
  • Tumors need to create new vessels in order to continue to grow. (ganoherb.com)
  • they fall into 1 of 3 categories, according to the presence of an interfacing arachnoidal membrane between the tumor and the cerebral vessels. (medscape.com)
  • Figure 4 (A) shows the distribution of microvessels in the tumor tissue slices of each group. (ganoherb.com)
  • Tissue distribution of the peptides was compared in healthy mice and athymic mice bearing AR4-2J tumors. (snmjournals.org)
  • Uterine fibroids are benign tumors of the uterine smooth muscle tissue, which occur in women of childbearing age at 30-50 years. (hindawi.com)
  • After the diameters of the subcutaneous tumors were approximately 6-8 mm, they began to feed Ganoderma lucidum triterpenoids (GLT, 1 g/kg/day), gefitinib (GEF, 15 mg/kg/day) or a combination of both for 14 days, and the experiment ended on the 15th day. (ganoherb.com)
  • No tumors were found in the liver of mice in the first experiment or in the livers and lungs of the other mice. (qigonginstitute.org)
  • Homozygous NU/J nude mice were fed selenium-deficient, torula yeast basal diet alone or supplemented with 0.15 or 1 mg Se/kg for 8 months in Experiment 1 and for 11 weeks in Experiment 2. (umd.edu)