• Although this study showed encouraging results in colon cancer, they hope to broaden the scope of this research to additional solid tumors in which the overexpression of Hsp27 has been observed, including lung, pancreatic and prostate cancers. (diwou.com)
  • The meeting was attended by ∼70 investigators and included formal presentations, panel group discussions, and two breakout sessions that addressed targeted therapies in hematologic and solid tumors. (aacrjournals.org)
  • Inhibition of Hsp90 has broad therapeutic potential for the treatment of patients with solid tumors and blood-related cancers, including cancers that are resistant to other drugs. (salesandmarketingnetwork.com)
  • We, therefore, describe a regimen of a combination therapy with noninvasive, acoustic immune priming and ablative radiation therapy to generate an in situ tumor vaccine, induce CD8+ T cells against tumor-associated antigens and provide a viable oncologic treatment option for solid tumors. (elsevierpure.com)
  • This trial will evaluate the maximum tolerated dose and safety of Debio 0932 in patients suffering from advanced solid tumors or lymphoma. (technologynetworks.com)
  • The first part of the study (Phase Ia) is an open-label, multi-centre dose escalation trial evaluating the safety and tolerability of escalating multiple dose-levels of Debio 0932 as a single agent given orally to patients suffering from advanced solid tumors or lymphoma. (technologynetworks.com)
  • The objective of this phase will be to further confirm the safety profile, pharmacokinetics and pharmacodynamics of Debio 0932 at a potential Phase II dose level and to screen anti-tumor activity in patients with certain types of advanced solid tumors. (technologynetworks.com)
  • 2008. NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis . (ub.edu)
  • Editorial: Albini A, Pfeffer U. A New Tumor Suppressor Gene: Invasion, Metastasis, and Angiogenesis as Potential Key Targets. (eurekalert.org)
  • A number of studies have proved that exosomes are important mediators for the initiation, progression, angiogenesis, and metastasis of tumors [ 10 ]. (hindawi.com)
  • The overexpression of Hsp27, which results in anti-apoptotic effects, has been linked to tumor resistance to cytotoxic drugs as well as the development of metastasis. (drugdiscoverynews.com)
  • The postoperative residual was regarded as a major cause of intrahepatic metastasis and tumor relapse. (insulin-receptor.info)
  • Tumor dormancy can lead to tumor recurrence locally or to metastasis at a distant site. (biomedcentral.com)
  • BACKGROUND: Cancer stem cells (CSCs) play a key role in tumor cell growth, drug resistance, recurrence, and metastasis. (bvsalud.org)
  • BACKGROUND: Epithelial-to-mesenchymal transition (EMT) and cancer stem-like cells (CSLCs) play crucial role in tumor metastasis and drug-resistance. (bvsalud.org)
  • DVL3 expression was also higher in CRC tissues with lymph node metastasis than tumor tissues without metastasis, and correlated with poor prognosis of CRC patients. (bvsalud.org)
  • The contents of Cd in the testis, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) production, messenger RNA (m RNA) levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6), protein expressions of heat shock proteins (HSPs) (HSP60, HSP70, and HSP90), and the histopathological changes of the testis were determined. (greenmedinfo.com)
  • Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with spondyloarthritis. (cdc.gov)
  • A series of studies have revealed that exosomes-mediated intercellular transfer of proteins, nucleic acids, and metabolites plays a crucial role in the initiation and progression of HCC, hypoxia and angiogenesis, chemotherapy sensitivity, and cell death mode and regulates the immune microenvironment. (hindawi.com)
  • We laid particular focus on those researches that reveal how exosomes regulate the tumor immune microenvironment (TIME) and how exosomal cargos affect the progression of HCC. (hindawi.com)
  • HCC-derived exosomes participate in changing tumor progression by regulating the tumor microenvironment and tumor immune status [ 14 , 15 ]. (hindawi.com)
  • Cellular transformation to neoplasm, tumor formation, and progression require an inherent crosstalk between the tumor microenvironment and the tumor. (biomedcentral.com)
  • The tumor microenvironment or tumor stroma comprises various cell types, including cancer-associated fibroblasts (CAFs), immune cells, endothelial cells, and mesenchymal cells. (biomedcentral.com)
  • Exactly why this is so is not fully understood, but a number of factors in the tumour microenvironment have been postulated to play a role including hypoxia, pH, and higher levels of adenosine, lactate and immunosuppressive factors such as IL-10 and PD-L1 [ 1 ]. (biomedcentral.com)
  • In this short review, we summarize recent experimental and clinical evidence for these three mechanisms and other possible tumor microenvironment mechanisms that may influence tumor dormancy. (biomedcentral.com)
  • A tumor microenvironment that is altered (such as by frontline treatment) can mediate tumor cell entrance into, maintenance, and exit from dormancy through interaction with cells at niches, such as endothelial cells, stroma, or immune cells. (biomedcentral.com)
  • Molecular features of these tumors have expanded our vision of tumorigenesis and progression and provided abundant specifically targeted pathways [ 5 ]. (hindawi.com)
  • As an important member of the miRNA family, miR-381-3p also mediates tumor progression. (hindawi.com)
  • In this paper, we reviewed the recent researches on the multiple roles of tumor-associated exosomes in the progression of HCC. (hindawi.com)
  • What is the role of EpoR in the facilitation of tumor progression? (cancernetwork.com)
  • However, co-culture in vitro experiments and co-implantation in vivo experiments showed that the combination of low doses of cisplatin (10 μM) and low doses of pirfenidone (0.5 mg/mL), in both CAFs and tumors, lead to increased cell death and decreased tumor progression, respectively. (biomedcentral.com)
  • Tumor dormancy may contribute to tumor progression and relapse, either locally or metastatically at distant sites, years or decades after treatment. (biomedcentral.com)
  • Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
  • These tumor proteins, when first defined, were referred to as tumor associated antigens. (jcancer.org)
  • Monoclonals developed from these tumor antigens are in the initial phases of investigation with regard to their specificity and antitumor activity. (jcancer.org)
  • Mabs capable of targeting the malignancies noted above were produced following immunization of BALBc mice with the Tumor Specific Antigens. (jcancer.org)
  • Dendritic cells (DCs) are antigen-presenting immune cells pivotal to anti-cancer immunity because of their unique ability to capture tumour-associated antigens and use them to activate cancer-killing cytolytic T cells. (biomedcentral.com)
  • The monoclonals, so produced, were not only more efficient in controlling tumor growth but minimized the development of a HAMA response. (jcancer.org)
  • Monoclonals that we were able to develop from tumor specific proteins derived from colon and pancreas cancer were found capable of targeting those tumors to induce apoptosis. (jcancer.org)
  • However, liver transplantation may be inappropriate for subjects with SB 525334 lung metastatic tumors or those unable to undergo surgical operation. (insulin-receptor.info)
  • Tumor cell dormancy may help to explain treatment resistance and recurrence or metastatic reactivation. (biomedcentral.com)
  • Overexpression of TEAD4 significantly increased proliferation and migration rates in HCC cells in vitro as well as tumor growth in vivo . (nih.gov)
  • Additionally, RNA sequencing analysis of TEAD4 -overexpressing HCC cells demonstrated that TEAD4 overexpression was associated with the up-regulation of genes involved in epithelial-to-mesenchymal transition, proliferation, and protein-folding pathways. (nih.gov)
  • Among the most up-regulated genes following TEAD4 overexpression were the 70-kDa heat shock protein (HSP70) family members HSPA6 and HSPA1 A. Chromatin immunoprecipitation-quantitative real-time polymerase chain reaction experiments demonstrated that TEAD4 regulates HSPA6 and HSPA1A expression by directly binding to their promoter and enhancer regions. (nih.gov)
  • His work has a strong focus on breast cancer, including risk factors, mutation patterns, overexpression of heat shock proteins, and triple-negative breast cancer. (who.int)
  • Introduced Bacille Calmette-Guérin (BCG), the tuberculosis vaccine, into experimental cancer research as a way to stimulate non-specific resistance to tumor growth. (wikipedia.org)
  • Discovery of tumor necrosis factor (TNF), a key immune signaling molecule (cytokine) that, in addition to its promise for the treatment of cancer and other diseases, has provided a powerful research tool in biomedicine (nearly 88,000 articles in PubMed as of May 25, 2011) (1975). (wikipedia.org)
  • Through study findings published Friday in Cell Reports , a team of scientists at VCU Massey Cancer Center discovered a previously unknown interaction between proteins that is responsible for supplying energy to tumor cells and could hold significant implications for the development of future treatments for colon cancer. (diwou.com)
  • By blocking the function of these heat shock proteins, they were essentially able to reactivate the cellular hand that could pull the plug on the power source connected to the cancer, Senkal said. (diwou.com)
  • Jeremy J.W. Chen, Ph.D., of National Chung-Hsing University, Pan-Chyr Yang, M.D., Ph.D., of National Taiwan University in Taiwan, and colleagues increased or blocked the expression of HLJ1 in lung carcinoma cells in the lab and examined the gene's expression in tumor and surrounding tissue cells of 71 patients with non-small-cell lung cancer. (eurekalert.org)
  • In addition, HLJ1 expression was lower in tumor tissue than normal tissue in 55 of the 71 patients studied, and patients with high HLJ1 expressing tumors had reduced cancer recurrence and lived longer than those with low expressing tumors. (eurekalert.org)
  • The authors conclude that HLJ1 expression is a novel tumor suppressor in non-small-cell lung cancer. (eurekalert.org)
  • Elevated levels of circulating enzyme lactate dehydrogenase (LDH) have been historically considered in oncology as a marker of bad prognosis, usually attributed to elevated tumour burden and cancer metabolism. (stanford.edu)
  • His research program spans a range from basic studies in molecular cancer genetics and tumor immunology to translational clinical cancer research testing novel immunotherapeutic strategies and targeted compounds in vivo for the treatment of gynecologic malignancies. (yale.edu)
  • Dr. Jaeger is investigating how a protein called the Heat Shock Transcription Factor 1 (HSF1), a potent pro-survival transcription factor, orchestrates changes in the three-dimensional architecture of chromosomes to activate tumor supportive gene expression programs in diverse cancer types. (damonrunyon.org)
  • RP101 is an orally administered, patent-protected small molecule that binds to heat shock protein 27 (Hsp27)-a chaperone protein found in abnormally high levels in cancer cells-and inhibits its anti-apoptotic effects. (drugdiscoverynews.com)
  • Researchers have identified a gatekeeper protein that prevents pancreatic cancer cells from transitioning into a particularly aggressive cell type and also found therapies capable of thwarting those cells when the gatekeeper is depleted. (mdanderson.org)
  • A team from The University of Texas MD Anderson Cancer Center describes this week in the journal Nature a series of preclinical experiments using patient-derived tumor xenografts (PDXs) and mouse models that point to potential treatments for patients with a rapidly-progressing and resistant subgroup of tumor cells. (mdanderson.org)
  • A key challenge in treating cancer stems from molecular and genomic variability of tumor cells, which causes functional differences across cells that can fuel resistance to treatment. (mdanderson.org)
  • We are working to dissect the cell populations within tumors to attempt to understand the functional vulnerabilities of each, then to plan for more rational combinatorial treatment approaches," said Giulio Draetta , M.D., Ph.D., professor of Genomic Medicine and director of MD Anderson's Institute for Applied Cancer Science . (mdanderson.org)
  • Therefore, a combined therapy that targets both the tumor cell and the CAFs might lead to novel therapies in cancer. (biomedcentral.com)
  • First, they show that in mouse DCs oxidized lipids function as a sink that traps the heat shock chaperone HSP70, a molecular target of emerging anti-cancer strategies. (biomedcentral.com)
  • These observations are discussed briefly in the context of lipid droplet function and pMHC-I trafficking in tumour-associated DCs, as well as HSP70's pleiotropic and incompletely understood roles - and what they mean for future cancer therapy designs. (biomedcentral.com)
  • GAITHERSBURG, Md. and CAMBRIDGE, Mass., Aug. 28 (HSMN NewsFeed) -- MedImmune, Inc. (Nasdaq: MEDI ) and Infinity Pharmaceuticals, Inc. today announced that they have entered into an agreement to jointly develop and commercialize novel small molecule cancer drugs targeting Heat Shock Protein 90 (Hsp90) and the Hedgehog cell-signaling pathway. (salesandmarketingnetwork.com)
  • Hsp90 functions to stabilize and maintain the activity of proteins in the cancer cell, thereby allowing a cancer cell to survive despite an abundance of misfolded and unstable proteins. (salesandmarketingnetwork.com)
  • We demonstrate that LOFU significantly induces expression and cell surface localization of heat shock proteins in murine breast (4T1) and prostate adenocarcinoma (TPSA23) cancer cell lines. (elsevierpure.com)
  • Colorectal cancer (CRC) is a common tumor with high morbidity and mortality. (bvsalud.org)
  • When Old began his career in 1958, tumor immunology was in its infancy. (wikipedia.org)
  • Old's contributions to research established many of the principles and priorities of modern tumor immunology. (wikipedia.org)
  • With the ability of the mAbs to demonstrate therapeutic antitumor activity in those patients with relatively advanced malignancies, the term tumor specific was introduced. (jcancer.org)
  • It is required by FDA that the potential effects of tumor control and toxicity be defined using the naked antibodies produced under GMP conditions, In those situations where patients with recurrent malignancies are to be studied we have come to realize that a number of factors can influence the response to monoclonal therapy. (jcancer.org)
  • As such we plan to eventually employ the therapeutic mAbs in combination with chemotherapy as a means of enhancing the immunogenicity of the tumor system being treated and to possibly weaken the malignant growth for easier destruction by the mAb. (jcancer.org)
  • As a molecular chaperone, HSP90 regulates the conformational maturation and functional stability of many signaling proteins in cells, serves important roles in cell growth, differentiation, apoptosis and tumor development and is an important antitumor target ( 8 , 9 ). (spandidos-publications.com)
  • Dormancy can be induced by more than one mechanism: cellular dormancy (quiescence), angiogenic dormancy (tumor mass size limit), and immunologic dormancy (immunosurveillance, balance between proliferation and apoptosis). (biomedcentral.com)
  • However, many patients who exhibit no clinical symptoms after frontline therapy subsequently suffer, often many years later, aggressive tumor recurrence. (biomedcentral.com)
  • More CD8 T cells infiltrated and were activated after PD-L1 mAb treatment in mice with immunogenic MOC1 tumors, which were stable or increased by the addition of rapamycin, but suppressed when PD901 was added. (aacrjournals.org)
  • Both as a single agent and combined with the chemotherapy gemcitabine, AUY922 increased the response rate and lengthened survival of mice whose tumors faithfully recapitulated key features of human pancreatic cancers. (mdanderson.org)
  • After having shown efficacy in mice in various tumor xenografts, Debio 0932 has now entered clinical development. (technologynetworks.com)
  • Tumor xenograft experiments were employed to examine the tumorigenicity of CRC cells in nude mice. (bvsalud.org)
  • RESULTS: PC decreased the proliferation of CRC cells (HT29 and HCT-116), and improved the sensitivity of CRC cells to oxaliplatin (L-OHP), as well as inhibited tumor growth in nude mice. (bvsalud.org)
  • Anti-PD-L1 enhanced durable primary tumor control and survival when combined with mTOR (rapamycin), but not in combination with MEK inhibition (PD901) in immunogenic MOC1 tumors. (aacrjournals.org)
  • In vivo LOFU followed by ablative radiation therapy (RT) results in primary tumor cure, upregulation of a cytotoxic immune response and induction of immunological memory by inhibiting secondary tumor growth upon re-challenge with tumor cells. (elsevierpure.com)
  • In vivo antibody depletion revealed a CD8 T-cell-dependent, and not NK cell-dependent mechanism of tumor growth inhibition after treatment with rapamycin and PD-L1 mAb, ruling out significant effects from NK cell-mediated antibody-dependent cellular cytotoxicity. (aacrjournals.org)
  • Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. (nature.com)
  • At 24 h post-operatively, we assessed the serum levels of creatinine and urea nitrogen, expression levels of peroxisome proliferator-activated receptor gamma (PPAR-γ) and NF-κB-related (p-IKK-β and IκB-α) proteins, and mRNA expression levels of the inflammatory cytokines, including TNF-α and MCP-1, in the renal tissue of various study groups. (frontiersin.org)
  • The results indicated that ABP improved Cd-caused testicular tissue damageby increasing the SOD and GSH-Px activities: decreasing the Cd accumulation and MDA content, mRNA levels of TNF-α, IL-1β, and IL-6, and protein expressions of HSP60, HSP70, and HSP90. (greenmedinfo.com)
  • Identification (independently, along with two other groups) of the p53 protein, the gene for which is mutated in approximately 50 percent of cancers (1979). (wikipedia.org)
  • This proposal is centered around Magnetic Resonance Imaging (MRI) Guided Focused Ultrasound (FUS) and two of its medical applications, tumor ablation and gene therapy. (europa.eu)
  • Thus, high local and temporal control of gene therapy can be achieved using controlled periods of local heat elevation. (europa.eu)
  • in particular, all three tested Se chemical forms up-regulated putative tumor suppressor IGFBP-3 gene. (usda.gov)
  • Collectively, our data demonstrated that Se increased the expression of tumor suppressor-related genes (IGFBP3, HHIP) and decreased pro-inflammatory gene (CXC L9, HSPB2) expression at cellular nutritional Se dose, even though Caco-2 colon cells were resistant to Se deprivation. (usda.gov)
  • Increasing evidence suggests that the three dimensional architecture of chromosomes can influence the unique gene expression programs that support tumor growth. (damonrunyon.org)
  • Supplementary MaterialsS1 Fig: Comparative genomics from the gene and protein. (neuroart2006.com)
  • Genovese and colleagues found, in a subset of tumor cells, after the original oncogenic driver fades, depletion of a gene called SMARCB1 results in a cellular change to mesenchymal status, a mobile and invasive cell state. (mdanderson.org)
  • Heat shock protein 70 gene polymorphisms in Mexican patients with spondyloarthropathies. (cdc.gov)
  • In the course of their research they found tremendously high amounts of HSP90 in the tumor tissue of patients. (mpg.de)
  • In a further step the researchers found that a well known active principle called Silibinin binds to the C-terminus of HSP90 protein thus allowing glucocorticoid receptor molecules to detach from HSP90. (mpg.de)
  • The present study aimed to investigate the effects of changes in heat shock protein (HSP)90β expression and verify whether HSP90β regulates EAAT2 expression in a cerebral ischemia‑reperfusion injury model. (spandidos-publications.com)
  • Heat shock protein (HSP) 90 is abundant in cells, mainly in the form of homodimers, including HSP90α and HSP90β. (spandidos-publications.com)
  • In preclinical studies, Hsp90 and the Hedgehog pathway appear to be implicated in the growth and survival of a broad range of blood-related and solid tumor types. (salesandmarketingnetwork.com)
  • Debiopharm Group™ (Debiopharm) announced that it has started patient enrolment in its Phase I clinical trial for the small molecule inhibitor of heat shock protein 90 (Hsp90), Debio 0932. (technologynetworks.com)
  • Regardless of the type or the physiological or pathological state of the originating cell, exosomes share common features as enriched with nucleic acids, lipids, and proteins [ 4 ]. (hindawi.com)
  • These ox-tr lipids contain reactive functional groups that were capable of mediating a covalent attachment to HSP70, and lipid droplets of DCs exposed to tumour extracts but not of controls strongly accumulated HSP70. (biomedcentral.com)
  • The human Hsp60 is a member of a highly conserved family which includes molecular chaperones from several species including plant Hsp60 (known as Rubisco binding protein), and bacterial GroEL, a major antigen of mycobacteria. (enzolifesciences.com)
  • A New Tumor Suppressor DnaJ-Like Heat Shock Protein, HLJ1, and Survival of Patients With Non-Small-Cell Lung Carcinoma. (eurekalert.org)
  • Rabbit Polyclonal to DRP1 subjects achieved tumor-free survival following liver transplantation. (insulin-receptor.info)
  • Finally, by overexpressing TEAD4 in yes-associated protein ( YAP )/transcriptional coactivator with PDZ binding motif ( TAZ )-knockdown HCC cells, we showed that the effect of TEAD4 on cell proliferation and its regulation of HSP70 expression does not require YAP and TAZ, the main effectors of the Hippo signaling pathway. (nih.gov)
  • Activated protein C resistance and low molecular weight lipoprotein (a): dual pathogens for atherothrombosis? (mcmaster.ca)
  • By combining lipidomics and molecular dynamic simulations the authors show that oxidatively truncated (ox-tr) triacylglycerides accumulate in large lipid droplets of tumour-associated mouse DCs, and that these highly electrophilic species are predicted to preferentially occupy the droplet surface where they can directly access cytosolic proteins. (biomedcentral.com)
  • Three molecular mechanisms involved in tumor dormancy have been identified: cellular dormancy (quiescence or mitotic arrest), angiogenic dormancy (limited tumor size), and immunologic dormancy (immunosurveillance, balance between clearance and proliferation) (Figure 1 ). (biomedcentral.com)
  • Senkal and his team began extensively screening cells in the lab to identify what proteins regularly interact with ceramide-producing proteins to identify potential patterns that could warrant further investigation. (diwou.com)
  • Glioma is the most frequent primary central nerve tumor, which originates from glial progenitor cells [ 1 ]. (hindawi.com)
  • After Silibinin treatment, tumor cells resumed normal ACTH production, tumor growth slowed down and symptoms of CD disappeared. (mpg.de)
  • Rapamycin increased IFNγ production capacity in peripheral and tumor-infiltrating CD8 T cells. (aacrjournals.org)
  • The c-GPx activity of Se-deficient Caco-2 cells was 10.8 mU/mg protein compared with high c-GPx (133.6~146.3 mU/mg protein) activity in Caco-2 cells supplemented with 500 nmol/L selenite, SeMSC or SeMet (three tested Se chemical forms) during 7- day serum free culture condition. (usda.gov)
  • Compared with normal cells, tumor cells secrete more exosomes, and the number of exosomes secreted by different tumor cells varies dramatically [ 6 ]. (hindawi.com)
  • Exosomes were first described in 1981 as ATPase-containing vesicles exfoliated from cells and were found in various normal cells and tumor cells [ 16 ]. (hindawi.com)
  • The aim of the present study was to identify whether P. gingivalis heat‑shock protein 60 (HSP60) induced the dysfunction of human umbilical vein endothelial cells (HUVECs) in vitro. (spandidos-publications.com)
  • The team also found a vulnerability for mesenchymal cells: they are overly reliant on accelerated protein production to meet increased metabolic needs. (mdanderson.org)
  • We will also look at the combination of mAbs with immunostimulants such as GMCSF and IL-2 (fusion proteins) and eventual conjugation of the mAbs with alpha and possibly B -emitters to help in targeting bystander cells. (jcancer.org)
  • Tumor cells desired to adhere to collagen revealed within PT-triggered endothelial gaps 1-integrins within the tumor cell surface. (neuroart2006.com)
  • In a recent publication in Nature Communications the group of Dr. Dmitry Gabrilovich takes us one step closer to understanding why lipid accumulation impairs the function of tumour-associated dendritic cells (DCs). (biomedcentral.com)
  • Proteins are the mainstay of structural and signaling elements of all cells. (salesandmarketingnetwork.com)
  • Understanding the dormant stage of tumor cells may help in discovering ways to maintain the dormant state or permanently eliminate dormant residual disseminated tumor cells. (biomedcentral.com)
  • Tumor dormancy is a recognized clinical phenomenon in which disseminated tumor cells (DTCs) remain occult, asymptomatic, and undetectable over a prolonged period of time. (biomedcentral.com)
  • Dormancy can occur at the earliest stage of tumor development but also when remnant tumor cells escape treatment. (biomedcentral.com)
  • FUS has been known to be very effective to heat tissue locally. (europa.eu)
  • I) Application of high intensity FUS to destroy a tumor without damaging surrounding tissue. (europa.eu)
  • The presence of endotoxin can cause pyrogenic reactions in host organisms such as endotoxin shock, tissue injury, and even death. (genscript.com)
  • Tumor necrosis factor-α (TNF-α), an important proinflammatory cytokine, exerts a variety of physiologic and pathogenic effects that lead to tissue destruction. (molvis.org)
  • Focal ablative therapies have been primarily used for local tumor ablation. (elsevierpure.com)
  • This heat shock protein helps to correctly fold the glucocorticoid receptor, another protein which in turn inhibits the production of ACTH. (mpg.de)
  • Significantly higher expression was observed in tumor necrosis factor receptor in the TCA treatment group compared to the parent compound - TCE. (cdc.gov)
  • Protein extraction and purification kits, along with rabbit anti-rat peroxisome proliferator-activated receptor-gamma (anti-PPAR-γ), IκB kinase beta phosphorylation (anti-p-IKK-β), and inhibitor κB-alfa (IκB-α) antibodies were purchased from Wuhan Boster Biological Technology, Ltd., (Hubei, China). (frontiersin.org)
  • Here we propose the use of low intensity focused ultrasound (LOFU), a noninvasive, nontoxic, conformal therapy, to deliver acoustic stress to the tumor for immune priming. (elsevierpure.com)
  • Mounting clinical evidence associates ESA use with increased mortality rates, and laboratory evidence has shown the drugs can promote tumor growth. (cancernetwork.com)
  • The impact on cell death in vitro as well as tumor growth in a mouse model was determined. (biomedcentral.com)
  • Interestingly, recent studies have found that PC exhibits the inhibitory effect on tumor growth. (bvsalud.org)
  • The common characteristics of the Hsp60s include i) high abundance, ii) induction upon environmental stress such as heat shock, iii) homo -oligomeric structures of either 7 or 14 subunits which reversibly dissociate in the presence of Mg and ATP, iv) ATPase activity and v) a role in folding and assembly of oligomeric protein structures. (enzolifesciences.com)
  • Hsps are intracellular proteins which are thought to serve protective functions against infection and cellular stress, however several studies indicate that members of the Hsp60 family are linked to a number of autoimmune diseases, artherosclerosis and chlamydial disease. (enzolifesciences.com)
  • By inhibiting Hsp27, it's thought that RP101 may prevent the onset of chemoresistance and keep tumors sensitive to chemotherapy. (drugdiscoverynews.com)
  • An unusual cellular factor potentiates protein-DNA complex assembly between Oct-1 and Vmw65. (mcmaster.ca)
  • Over the past decade, numerous studies indicate that various mechanisms of tumor dormancy exist, including cellular dormancy (quiescence), angiogenic dormancy, and immunologic dormancy. (biomedcentral.com)
  • SDS-PAGE analysis: Lane 1: MWM, Lane 2: 1.0 µg of purified Human Hsp60 protein. (enzolifesciences.com)
  • P. gingivalis HSP60 at a concentration of 10 ng/l significantly decreased the expression levels of VE‑cadherin and eNOS protein at 24 h stimulation, whereas no difference in these proteins was identified following a low dose of P. gingivalis HSP60 (1 ng/l). (spandidos-publications.com)
  • P. gingivalis HSP60 at 100 ng/l significantly downregulated the expression levels of VE‑cadherin and eNOS protein at 12 h in HUVECs. (spandidos-publications.com)
  • Furthermore, atherosclerosis can be triggered and aggravated by the pathogen-driven antigenic peptide from P. gingivalis heat-shock protein 60 (HSP60) ( 15 - 17 ). (spandidos-publications.com)
  • All experienced a relapse of hepatoblastoma during treatment, indicating that tumor relapse may be the major cause of mortality among patients with hepatoblastoma. (insulin-receptor.info)
  • HLJ1 is a protein involved in a cell's defense mechanism against outside stress. (eurekalert.org)
  • Similarly, expression of heat shock protein 70 increased 8.8 fold in TCA treatment group compared to TCE treatment which had 2.7 fold increase. (cdc.gov)
  • Recent evidence suggests that elevated LDH levels could be independent from tumour burden and contain a negative predictive value, which could help in guiding treatment strategies in immuno-oncology. (stanford.edu)
  • Under the terms of the deal, Fraunhofer IZI is conducting real-time monitoring of tumor engraftment, tumoricidal efficacy and response to treatment with RP101 in combination with standard-of-care chemotherapies. (drugdiscoverynews.com)
  • The preclinical work carried out by Curis suggests that Debio 0932 may be able to enhance the efficacy of treatment against certain tumors, where there currently is a large unmet medical need. (technologynetworks.com)
  • This led the team to look at a drug called AUY922, an inhibitor of heat shock protein 90, which blocks proteostasis - the creation, folding, distribution and degrading of proteins. (mdanderson.org)
  • Through their research, Senkal's team observed that the first flavor, ceramide synthase 1 (CerS1), was highly interactive with a particular protein known as heat shock protein 27 (Hsp27). (diwou.com)
  • however, the septic shock in the early onset of sepsis, which induced by cytokine storm and cardiac dysfunction, is also an important cause of death for septic patients, especially for the young patients with toxic shock syndrome or meningococcemia ( 2 ). (frontiersin.org)
  • Heart, as the pump organ, plays a key role in the pathology of septic shock. (frontiersin.org)
  • A retrospective cohort study reported that SIC developed in 13.8% of patients with sepsis and septic shock ( 5 ), which could be used as an outcome predictor in the septic patients ( 6 ). (frontiersin.org)
  • Arlen M, Arlen P, Tsang A, Wang X, Gupta R. The Therapeutic Value of Monoclonal Antibodies Directed Against Immunogenic Tumor Glycoproteins. (jcancer.org)