ProgressionXenograftProliferationAnti-tumorPatientsApoptosis and cell cycle arrestAngiogenesisPreceding tumor cellSolid tumorsBenign TumorsCellsGenesSuppressionMalignant intraocularCommon primary malignantTissuesMicroenvironmentBrain tumorDifferent tumorTissueAggressiveDownstreamNanoparticlesSurvivalOrallyLungProteinSympathetic nervouCancerousCancerOrganoidsTherapeuticSenescenceNecrosisPhenotypeCellularProteinsRenalMalignancyAbstractNeuroblastomaChromosomeTreatmentInhibitorsCorrelationMiceSignificantlyImmunosuppressionOncogenicMetabolism
Progression7
- While some patients experience spontaneous regression or differentiation of the tumor, others are affected by rapid and fatal tumor progression despite increasingly intensive treatment strategies [ 9 ]. (biomedcentral.com)
- Most of scientist have proved that overexpressed gas1 has the function of inhibiting tumor growth and progression in gliomas. (wikipedia.org)
- A MEK-independent role for CRAF in mitosis and tumor progression. (rndsystems.com)
- The importance of STAT activation to growth control in experiments using anti-sense molecules or dominant negative STAT protein encoding constructs performed in cell lines or studies in animals lacking specific STATs strongly indicate that STATs play an important role in controlling cell cycle progression and apoptosis. (nih.gov)
- The study identified 2 genes known to contribute to tumor progression and 8 known to be present in tumor cells but which have unknown functions. (frontiersin.org)
- Aggressive tumors typically demonstrate a high glycolytic rate, which results in resistance to radiation therapy and cancer progression via several molecular and physiologic mechanisms. (springer.com)
- These bone metastases produce osteoblastic lesions that are associated with high morbidity and high mortality [ 8 ] and attempts at delaying this tumor progression with chemotherapeutic agents have only prolonged survival a few months. (oncotarget.com)
Xenograft5
- As proof-of-concept, we show that in vivo knockdown of ASncmtRNAs results in drastic inhibition of tumor growth in a xenograft model of MDA-MB-231 subcutaneous tumors, further supporting this approach for the development of new therapeutic strategies against breast cancer. (uandes.cl)
- In B-Raf(V600E)-dependent tumor xenograft models, orally dosed PLX4720 causes significant tumor growth delays, including tumor regressions, without evidence of toxicity. (rcsb.org)
- Silibinin significantly inhibited xenograft tumor growth in nude mice, with no obvious toxicity. (jcancer.org)
- Importantly, silibinin effectively suppressed xenograft tumor growth in nude mice. (jcancer.org)
- For this work, I have used patient-derived xenograft mouse models and neuroblastoma cells grown as 3D tumor organoids. (lu.se)
Proliferation11
- During the development stage of the GAS1, it has been suggested that development GAS1 can not only inhibit cell proliferation but also control the cell death as well as growth of the cerebellum. (wikipedia.org)
- Our results suggest that ASncmtRNA targeting blocks tumor cell proliferation through reduction of essential cell cycle proteins, mediated by mitochondrial and nuclear miRNAs. (uandes.cl)
- Cellular senescence is a multifaceted process that arrests the proliferation of cells that are at risk of neoplastic transformation. (nature.com)
- Hypoxia and genetic defects that chronically drive proliferation leave such tumors dependent on a steady supply of nutrients, especially glucose. (springer.com)
- High tumor proliferation has previously been associated with response to chemotherapy. (lu.se)
- The aim of this research was to achieve cancer debulking and proliferation prevention by limiting 'cancer-sustaining' tumor niche inflammation through non-conventional oral approach employing anti-inflammatory agents and avoiding conventional cytotoxic agents. (ac.ir)
- Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. (hindawi.com)
- We demonstrate that UCN-01, at concentrations lower than those necessary to inhibit cancer cell growth, inhibit proliferation of human endothelial cells in vitro. (karger.com)
- Our study demonstrates that survivin and APE1/Ref-1 are significantly higher in human prostate cancer specimens compared to noncancerous controls and that APE1/Ref-1 redox-specific inhibition with small molecule inhibitor, APX3330 and a second-generation inhibitor, APX2009, decreases prostate cancer cell proliferation and induces cell cycle arrest. (oncotarget.com)
- To investigate the effects of silibinin on the growth of oral cancer cells, cell proliferation and anchorage-independent colony formation tests were conducted on YD10B and Ca9-22 oral cancer cells. (jcancer.org)
- The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. (genetex.com)
Anti-tumor2
- The initial finding that Abcc10, a member of a ubiquitous family of proteins called ATP-binding cassette transporters, thwarts taxanes' anti-tumor activity was something of a surprise, says Hopper-Borge, because none of the other family members seem to have that ability. (news-medical.net)
- Preclinical evidence supports synergistic anti-tumor effects when downstream RAS/MAPK pathway inhibition is combined with cell cycle inhibition in CRC and PDAC," he said. (pharmalive.com)
Patients14
- By elucidating the mechanisms of anticancer effects after genistein treatment in brain tumor cells, there will be a premise for the incorporation of genistein dietary sources to complement radiotherapy in brain tumor patients. (manipal.edu)
- The identification of immunosuppressive factors within human tumor microenvironments, and the ability to block these factors, would be expected to enhance patients' antitumor immune responses. (aacrjournals.org)
- The work described here represents the entire discovery process, from initial identification through structural and biological studies in animal models to a promising therapeutic for testing in cancer patients bearing B-Raf(V600E)-driven tumors. (rcsb.org)
- With the development of tumor molecular heterogeneity theory(12), there are still some patients with GIST who are sensitive to radiotherapy, especially for the patients with advanced stage(13-16).In addition, with the development of imaging technology and modern tissue and organ radiation technology, it has become a reality to concentrate high-dose radiation locally in abdominal cavity tumors(12), which challenges RT's insensitivity to GISTs. (researchsquare.com)
- p53, mdm-2, p21, and mib-1 expression were assessed by immunohistochemical methods in primary tumors derived from 134 patients who took part in a randomized multicenter trial comparing docetaxel to sequential methotrexate and 5-fluorouracil (MF) in advanced breast cancer. (lu.se)
- Therefore, we see chances of reversing methylation in far more cancer patients in the future and arresting tumor growth in this way. (scienceblog.com)
- We equalize the limb length in these patients either by epiphysiodesis (growth plate closure) or by limb lengthening. (stmarysmc.com)
- Patients with this condition should receive an ultrasound for Wilm's tumor of the kidney until the age of 6. (stmarysmc.com)
- PURPOSE: Noninvasive coronary CT angiography (CCTA) was used to retrospectively analyze the characteristics of coronary artery disease (CAD) in patients with thoracic tumors and the impact of the results on clinical surgery decision-making, thus increasing the understanding of perioperative cardiac risk evaluation. (bvsalud.org)
- METHOD: A total of 779 patients (age 68.6 ± 6.6 years) with thoracic tumor (lung, esophageal, and mediastinal tumor) scheduled for non-cardiac surgery were retrospectively enrolled. (bvsalud.org)
- Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. (lu.se)
- 2014). genetic StudieS are carried out, uSing tuMour SaMPleS froM PatientS with excellent clinical data that have been collected at a PoPulation level or internationally, to Provide unique data coMbining the Pathology, geneticS, clinical featureS, and ePideMiology of tuMourS. (who.int)
- Changes in levels of circulating tumor DNA very closely followed treatment responses in these patients, and tracking levels of ctDNA may provide us with an early indicator of treatment resistance," said Dawson. (medscape.com)
- Vascular growth during implantation normal non-pregnant controls, 20 normal and placentation is critical for successful pregnant controls, 20 patients with mild gestation. (who.int)
Apoptosis and cell cycle arrest3
- Kaempferol has been shown to inhibit cell growth, induce apoptosis and cell cycle arrest in several tumors, but not in renal cell carcinoma (RCC). (nih.gov)
- A significant inhibition on cell growth, induction of apoptosis and cell cycle arrest were observed in 786-O and 769-P cells after kaempferol treatment compared with the control group. (nih.gov)
- This study is the first to show that VALD-3 induces apoptosis and cell cycle arrest in human breast cancer cells by suppressing Wnt/β-catenin signaling, indicating that it could be a potential drug for the treatment of breast cancer. (researchsquare.com)
Angiogenesis2
- Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. (rndsystems.com)
- Since hypoxia activates hypoxia-inducible factor (HIF-1)-dependent transcription in cancer cells that, in a paracrine fashion, drive tumor angiogenesis, we investigated the effects of UCN-01 on HIF-1-responsive promoter constructs. (karger.com)
Preceding tumor cell1
- This work adds to the elucidation of the molecular mechanisms behind cell cycle arrest preceding tumor cell apoptosis induced by ASncmtRNA knockdown. (uandes.cl)
Solid tumors1
- Photodynamic therapy (PDT) is a new treatment modality for solid tumors as well as for flat lesions of the gastrointestinal tract. (bioone.org)
Benign Tumors1
- Ollier's Disease - a condition where multiple enchondromas (benign tumors of cartilage) are found (usually asymmetrically) throughout the skeleton leading to leg length difference and deformity. (stmarysmc.com)
Cells49
- Decreased expression of NBPF1 in neuroblastoma cell lines with loss of 1p36 heterozygosity and the marked decrease of anchorage-independent clonal growth of DLD1 colorectal carcinoma cells with induced NBPF1 expression further suggest that NBPF1 functions as tumor suppressor. (biomedcentral.com)
- Forced expression of NBPF1 in HEK293T cells resulted in a G1 cell cycle arrest that was accompanied by upregulation of the cyclin-dependent kinase inhibitor p21 CIP1/WAF1 in a p53-dependent manner. (biomedcentral.com)
- The mouse cells, which appear the growth-arrested, were observed expression of Growth Arrest Specific-1 gene (GAS1). (wikipedia.org)
- Its metastatic potential depends on the phenotype of the tumor cells, and it frequently disseminates before diagnosis. (medscape.com)
- Tumor-induced glaucoma may be produced by obstruction of outflow pathways by pigment cells (pigment dispersion syndrome), melanin-laden macrophages (melanomalytic glaucoma), or tumor cells. (medscape.com)
- Genistein, a soy isoflavone, has been reported to exhibit multiple effects, such as inducing cell cycle arrest, triggering apoptosis, inhibiting the activation of NF K B and inactivating several signaling cascades in human cancer cells. (manipal.edu)
- Here, we demonstrate that genistein inhibits the growth of glioblastoma multiforme and medulloblastoma cells with different TP53 mutations and radio-responses by arresting the cells at G2/M phase of the cell cycle. (manipal.edu)
- Thus, we demonstrate, for the first time, that genistein induces growth arrest in association with telomerase inhibition in brain tumor cells via the suppression of TR- and TERT mRNA. (manipal.edu)
- We previously established that an unidentified factor, or factors, present in ovarian tumor ascites fluids reversibly inhibited the activation of T cells by arresting the T-cell signaling cascade. (aacrjournals.org)
- SncmtRNA is expressed in all proliferating cells, while ASncmtRNAs are expressed in normal proliferating cells, but is downregulated in tumor cells. (uandes.cl)
- ASncmtRNA knockdown with an antisense oligonucleotide induces massive apoptosis in tumor cell lines, without affecting healthy cells. (uandes.cl)
- In a newly published study, researchers tested the effects of reducing ether lipids on human skin cancer cells and primary breast tumors, finding that inactivating an enzyme critical to the formation of ether lipids substantially reduced the aggressiveness of the cancer cells. (scitechdaily.com)
- In the study, Nomura and his team tested the effects of reducing ether lipids on human skin cancer cells and primary breast tumors. (scitechdaily.com)
- This study sheds considerable light on the important role that AGPS plays in ether lipid metabolism in cancer cells, and it suggests that inhibitors of this enzyme could impair tumor formation," said Benjamin Cravatt, professor and chair of chemical physiology at The Scripps Research Institute, who is not part of the UC Berkeley study. (scitechdaily.com)
- Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. (nature.com)
- In the present study, the TCEE treatment induced cell cycle arrest and suppressed cell growth on both Hep3B and HepJ5 cells. (hindawi.com)
- This TCEE also demonstrates antitumor properties such as the induction of cell cycle arrest and activation of apoptosis on human colon, lung, melanoma, osteosarcoma, and pancreatic cancer cells [ 16 - 19 ]. (hindawi.com)
- Also arrests cells in prometaphase. (rndsystems.com)
- Consistent with the high degree of selectivity, ERK phosphorylation is potently inhibited by PLX4720 in B-Raf(V600E)-bearing tumor cell lines but not in cells lacking oncogenic B-Raf. (rcsb.org)
- In melanoma models, PLX4720 induces cell cycle arrest and apoptosis exclusively in B-Raf(V600E)-positive cells. (rcsb.org)
- 5) increasing the intrinsic radioresistance of normal cells through ketone bodies but decreasing that of tumor cells by targeting glycolysis. (springer.com)
- At the same time, the methyl groups bound to the DNA of cancer cells disappear and silenced tumor brakes are reactivated. (scienceblog.com)
- The present disclosure provides, at least in in part, methods and compositions for detecting and/or selectively targeting tumor cells, for example, for the diagnosis and/or treatment of cancer (e.g., ocular cancer). (justia.com)
- In some instances, the methods and compositions provided herein can be used to selectively kill cancerous tumor cells without damaging healthy cells. (justia.com)
- For example, viral-like nanoparticles that comprise (e.g., are conjugated to) photosensitive molecules may be selectively delivered to tumor cells and photoactivated by exposure to light. (justia.com)
- The results provide the first evidence from living organisms that Abcc10 is a cell's built-in protection against the effects of powerful drugs, and raises the possibility of using Abcc10 inhibitors to break down that resistance and sensitize tumor cells to anticancer agents. (news-medical.net)
- For that reason, Hopper-Borge thinks the best approach may be developing inhibitors that work only in tumor cells or coming up with compounds that modulate, rather than completely inhibit the protein's activity. (news-medical.net)
- The combined treatment of Flavopiriol and Lonafarnib in BG1-cells showed a slightly increased cell cycle arrest in the subG1-fraction in selected concentrations. (uni-marburg.de)
- The aim of the present investigation was to elucidate the cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads to cell cycle arrest and apoptosis in vitro in keratinocytes, the target cells in psoriasis. (hindawi.com)
- UCN-01, a protein kinase C (PKC) inhibitor, induces growth arrest and apoptosis in cancer cells and was recently introduced in a phase I clinical trial. (karger.com)
- In the present study, we investigated the effects of kaempferol and the underlying mechanism(s) on the cell growth of RCC cells. (nih.gov)
- MTT assay and colony formation assay were used to study cell growth, and flow cytometry was used to study apoptosis and cell cycles in different RCC cells treated with various doses of kaempferol. (nih.gov)
- Moreover, the results clearly showed that kaempferol causes a strong inhibition of the activation of the EGFR/p38 signaling pathways, upregulation of p21 expression and downregulation of cyclin B1 expression in human RCC cells, together with activation of PARP cleavages, induction of apoptotic death and inhibition of cell growth. (nih.gov)
- This action allows Ibrance to arrest the frenzied growth and multiplication of tumor cells, preventing the malignancy from progressing. (pharmalive.com)
- Flow cytometry analysis showed that VALD-3 triggered cell cycle arrest and induced apoptosis of breast cancer cells. (researchsquare.com)
- By xenografting human breast cancer cells into nude mice, we found that VALD-3 significantly suppressed tumor cell growth while showing low toxicity against major organs. (researchsquare.com)
- The fibroblast cell line was less affected by phototoxicity than the tumor cells to a variable degree. (bioone.org)
- Well-differentiated tumor cells showed higher toxicity than less-differentiated cells. (bioone.org)
- Moreover, it induced cell cycle arrest in the G0/G1 phase, apoptosis, and ROS generation in these cells. (jcancer.org)
- Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway. (jcancer.org)
- Emerging evidence suggests that cancer stem cells (CSCs), a subpopulation of tumor cells, have the properties of self-renewal, heterogeneous progeny, drug-resistance, and carcinogenesis in vitro and in vivo ( 4 , 5 ). (spandidos-publications.com)
- Farnesyltransferase inhibitor R115777 (zarnestra, tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells. (nyu.edu)
- Overview of Carcinoid Tumors Carcinoid tumors develop from neuroendocrine cells in the gastrointestinal tract (90%), pancreas, pulmonary bronchi, and rarely the genitourinary tract. (msdmanuals.com)
- Treatment of neuroblastoma PDX cells with ARRY-520 resulted in mitotic arrest and subsequent cell death. (lu.se)
- Rigosertib reduced cell viability of neuroblastoma cells and caused cell cycle arrest in the G2/M phase. (lu.se)
- In a recent study, researchers compared radiographic imaging of tumors with an assay of ctDNA, cancer antigen 15-3 ( CA 15-3 ), and circulating tumor cells in 30 women with MBC who were receiving systemic therapy. (medscape.com)
- [ 4 ] CA 15-3 levels and numbers of circulating tumor cells were measured at identical time points. (medscape.com)
- ctDNA was successfully detected in 97% women in whom somatic genomic alterations were identified, and CA 15-3 and circulating tumor cells were detected in 78% and 87%, respectively. (medscape.com)
- ctDNA levels showed a greater dynamic range, and greater correlation with changes in tumor burden, than did CA 15-3 or circulating tumor cells. (medscape.com)
Genes3
- Interestingly, the 1p36 region is frequently deleted not only in NB, but also in other human cancer types, including those of neural, epithelial and hematopoietic origin, indicating that the same tumor suppressor genes might be involved in a broad range of human cancers [ 11 ]. (biomedcentral.com)
- The prevalence of germline HRD (that is, the total number of pathogenic variants in homologous recombination genes) is higher in tumors from AAs, suggesting that the somatic differences observed have genetic ancestry origins. (nature.com)
- 1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
Suppression5
- Growth arrest-specific 1 plays a role in growth suppression. (wikipedia.org)
- Sager, R. Senescence as a mode of tumor suppression. (nature.com)
- In combination with the chemotherapy agents, TCEE treatment further enhanced the tumor suppression efficiency of cisplatin and doxorubicin. (hindawi.com)
- Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. (lsbio.com)
- FOXO3a is considered an evolutionarily conserved transcription factor involved in various cellular processes, including cell cycle arrest, DNA repair and tumor suppression ( 8 ). (spandidos-publications.com)
Malignant intraocular2
- See The Case of the Middle-Aged Woman with Sudden Unilateral Vision Loss , a Critical Images slideshow, to help identify and treat malignant intraocular tumors. (medscape.com)
- Choroidal melanoma is the most common primary malignant intraocular tumor and the second most common type of primary malignant melanoma in the body. (medscape.com)
Common primary malignant1
- Ciliary body melanoma is a subtype of uveal melanoma, the most common primary malignant tumor of the eye. (medscape.com)
Tissues2
- Erosion of the tumor into blood vessels in adjacent tissues, or areas of necrosis within the tumor, can lead to hyphema or vitreous hemorrhage. (medscape.com)
- Methods: Vascular endothelial growth factor (VEGF) and markers of epithelial-mesenchymal transition (EMT) were investigated immunohistochemically using tumor samples obtained from 196 GC tissues and adjacent tumor tissues. (bvsalud.org)
Microenvironment1
- The former include hypoxia, high lactate levels or the abundance of growth factors within the cellular microenvironment. (springer.com)
Brain tumor1
- brain tumor who had been declared brain dead af- results for both were negative. (cdc.gov)
Different tumor2
- We demonstrated that NBPF1 exerts different tumor suppressive effects, depending on the cell line analyzed, and provide new clues into the molecular mechanism of the enigmatic NBPF proteins. (biomedcentral.com)
- Although highly preliminary, the findings suggest that different tumor biological factors may predict response to different chemotherapy regimens with distinct mechanisms of action. (lu.se)
Tissue7
- The ocular tissue where these tumors arise, the uvea, is a densely pigmented layer that lies for the most part between the sclera and the retina. (medscape.com)
- The first solid tumor exomes to be investigated were from 11 breast and 11 colorectal cancer tissue samples. (frontiersin.org)
- We review the possible roles for calorie restriction (CR) and very low carbohydrate ketogenic diets (KDs) in modulating the five R's of radiotherapy to improve the therapeutic window between tumor control and normal tissue complication probability. (springer.com)
- Surprisingly, conjugation of photosensitive molecules to viral-like nanoparticles does not interfere with the tissue/tumor tropism of the nanoparticles (e.g., the specificity of the viral-like nanoparticles for a particular host tumor tissue or tumor cell). (justia.com)
- The overexpression of profibrotic cytokine, namely transforming growth factor β (TGF-β) due to excessive inflammation and tissue damage, induces kidney fibrosis. (researchgate.net)
- In the past 5 years, there has been an explosion of breast cancer research on circulating tumor DNA (ctDNA), fueled by the idea that ctDNA may provide a liquid biopsy alternative to tissue biopsies. (medscape.com)
- In addition, clinicians now recognize that tumors can be heterogeneous and that a single tissue biopsy may not be representative of all of the changes within a tumor. (medscape.com)
Aggressive2
- We find that lung squamous cell carcinoma tumors from AAs exhibit higher genomic instability-the proportion of non-diploid genome-aggressive molecular features such as chromothripsis and higher homologous recombination deficiency (HRD). (nature.com)
- Small cell lung cancer (SCLC), a poorly differentiated and highly aggressive tumor, constitutes approximately 15% of all lung cancers ( 1 ). (spandidos-publications.com)
Downstream3
- In response to DNA-damaging agents, the wild-type p53-activated fragment 1 (WAF1 also known as p21) is an important downstream effector in the p53-specific growth arrest pathway. (lu.se)
- Combining upstream EGFR inhibition, midstream BRAF inhibition and downstream ERK inhibition fits squarely within Erasca's strategies to erase cancer and has potential to limit pathway reactivation, offering the therapeutic potential to comprehensively shut down the RAS/MAPK pathway in this tumor type," Lim noted at the time. (pharmalive.com)
- Conversely, FOXO3a overexpression suppresses cancer cell growth, induces apoptosis, and reduces tumor size by regulating downstream effectors ( 10 ). (spandidos-publications.com)
Nanoparticles3
- Thus, various aspects of the disclosure provide tumor-targeting viral-like nanoparticles that comprise photosensitive molecules conjugated to capsid proteins. (justia.com)
- In-vitro, the nanoparticles manifested best and sustained release in moderately acidic (pH 4.5) milieu enabling passive tumor targeting potential. (ac.ir)
- The anti-inflammatory nanoparticles manifested tumor specific release potential exhibiting selective cytotoxicity at cancerous milieu with slightly acidic environment and activated inflammatory pathways. (ac.ir)
Survival4
- Due to the role of oncogenic transcriptional activators NFĸB and STAT3 in survivin protein expression, and APE1/Ref-1 redox activity regulating their transcriptional activity, we assessed selective inhibition of APE1/Ref-1's redox function as a novel method to halt prostate cancer cell growth and survival. (oncotarget.com)
- In vivo, combination treatment resulted in slower tumor growth and increased survival of neuroblastoma PDX models. (lu.se)
- KSP inhibition caused tumor regression in vivo and resulted in increased survival of multiple PDX models. (lu.se)
- In vivo, rigosertib treatment resulted in decreased tumor growth and increased survival of PDX mice. (lu.se)
Orally1
- Lonafarnib works as an orally available farnesyltransferase inhibitor against tumor growth in ras-dependent and ras-independent neoplasia. (uni-marburg.de)
Lung1
- To improve our understanding of longstanding disparities in incidence and mortality in lung cancer across ancestry, we performed a systematic comparative analysis of molecular features in tumors from African Americans (AAs) and European Americans (EAs). (nature.com)
Protein4
- Growth arrest-specific protein 1 is a protein that in humans is encoded by the GAS1 gene. (wikipedia.org)
- GAS1 was identified as a pleiotropic protein with the function of cell arrest and apoptosis. (wikipedia.org)
- Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) interacts with CDK2AP2, modulates the actions of transforming growth factor-B1, cyclin-dependent kinase 2 and retinoblastoma protein, and closely interacts with micro-RNA21 and micro-RNA25. (cancerindex.org)
- Analysis of KSP expression across multiple tumor types demonstrated that neuroblastoma is highly dependent on this protein. (lu.se)
Sympathetic nervou2
- NB tumors are derived from the sympathetic nervous system and account for approximately 15% of cancer deaths in children [ 8 ]. (biomedcentral.com)
- Neuroblastoma is a childhood tumor of the sympathetic nervous system and the most common tumor form diagnosed in infants. (lu.se)
Cancerous1
- In contrast, in many cancerous cell lines and tumors, where growth factor dysregulation is frequently at the heart of cellular transformation, the STAT proteins (in particular Stats 1, 3 and 5) are persistently tyrosine phosphorylated or activated. (nih.gov)
Cancer10
- Considering this genetic defect and the frequent genomic alterations of the NBPF1 locus in several cancer types, we hypothesized that NBPF1 is a tumor suppressor. (biomedcentral.com)
- Lipids have a variety of uses for cellular structure, but what we're showing with our study is that lipids can also send signals that fuel cancer growth. (scitechdaily.com)
- In The Cancer Genome Atlas, we demonstrate that high genomic instability, HRD and chromothripsis among tumors from AAs is found across many cancer types. (nature.com)
- This cancer-sustaining inflammation is a critical target to arrest cancer growth. (ac.ir)
- We report that, in addition to direct inhibitory effects on endothelial cell growth, UCN-01 abrogates hypoxia-mediated transactivation of HIF-1-responsive promoters in a prostate cancer cell line. (karger.com)
- Our objective was to determine if CDK2AP1 mRNA expression levels were consistent with tumour-suppressive functions in breast cancer. (cancerindex.org)
- Oral cancer is one of the most prevalent malignant tumors worldwide. (jcancer.org)
- These findings suggest a tumor suppressor role for FOXO3a, which could constitute a potential target for cancer treatment. (spandidos-publications.com)
- These are divided into two group, those miRNAs that are upregulated in cancer which are likely to be acting as oncogenes and those downregulated in cancer which are likely to be acting as tumour suppressors. (ukessays.com)
- 1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
Organoids1
- Using 3D tumor organoids and orthotopic PDX models we showed that KSP-inhibition is a powerful treatment strategy against neuroblastoma. (lu.se)
Therapeutic1
- Therefore, a therapeutic strategy targeting CSCs may help cure malignant tumors, including SCLC ( 7 ). (spandidos-publications.com)
Senescence4
- Two powerful tumour suppressor pathways, controlled by the p53 and retinoblastoma (pRB) proteins, are important for establishing and maintaining the senescence growth arrest. (nature.com)
- Campisi, J. Cellular senescence as a tumor-suppressor mechanism. (nature.com)
- Braig, M. & Schmitt, C. A. Oncogene-induced senescence: putting the brakes on tumor development. (nature.com)
- Brg1 is also involved in cell growth arrest, senescence and tumour supression. (thermofisher.com)
Necrosis2
- After irradiation, cell lines with cytosolic or mitochondrial PPIX localization indicate a loss of mitochondrial transmembrane potential resulting in growth arrest, whereas membrane-bound PPIX induces a loss of membrane integrity and consequent necrosis. (bioone.org)
- Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha). (nyu.edu)
Phenotype2
- The Warburg phenotype provides tumors an enhanced resistance against cytotoxic insults. (springer.com)
- The results of our phenotype analysis also indicate that it is more likely that a panel of tumor biological factors instead of only one single factor may be needed for better prediction of chemotherapy response. (lu.se)
Cellular1
- Thus, attachment of methyl groups to DNA often inactivates important cellular growth brakes. (scienceblog.com)
Proteins1
- These proteins are latent in the cytoplasm and become activated through tyrosine phosphorylation which typically occurs through cytokine receptor associated kinases (JAKs) or growth factor receptor tyrosine kinases. (nih.gov)
Renal1
- Inhibits growth of renal and pancreatic tumors in mice. (rndsystems.com)
Malignancy1
- Other studies have investigated specific lipid signaling pathways, but what makes AGPS stand out as a treatment target is that the enzyme seems to simultaneously regulate multiple aspects of lipid metabolism important for tumor growth and malignancy. (scitechdaily.com)
Abstract1
- ABSTRACT We evaluated the prognostic value of serum endostatin and vascular endothelial growth factor (VEGF) for diagnosis of pre-eclampsia. (who.int)
Neuroblastoma1
- Additionally, forced expression of NBPF1 in two p53-mutant neuroblastoma cell lines also resulted in a G1 cell cycle arrest and CDKN1A upregulation. (biomedcentral.com)
Chromosome1
- GAS-1 gene has been identified as a putative tumor suppressor collocates on chromosome 9q21.3-22.1 where was considered to be a fragile site. (wikipedia.org)
Treatment6
- This article outlines several benign lesions and tumors of the external ear and gives the reader a basic understanding of their clinical features and treatment options. (medscape.com)
- The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules. (justia.com)
- Today's anticancer drugs often work wonders against malignancies, but sometimes tumors become resistant to the effects of such drugs, and treatment fails. (news-medical.net)
- In-vitro-treatment with Lonafarnib leads to a dose-dependent G2-arrest of glioblastomacells, lungcancer- and fibrosarcomacells. (uni-marburg.de)
- Although, most of these studies have focused on treatment of tumors, the effects and mechanism of action in keratinocytes are still poorly understood. (hindawi.com)
- Using molecular characterization of treatment resistance and metastatic relapse we aim to identify new approaches for targeting resistant tumors with novel drugs and drug combinations. (lu.se)
Inhibitors1
- Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites. (nyu.edu)
Correlation1
- Levels of ether lipids - a class of lipids that are harder to break down - are particularly elevated in highly malignant tumors, although the nature of that correlation has been unclear for decades. (scitechdaily.com)
Mice2
- Among the mice that had the AGPS enzyme inactivated, the tumors were nonexistent," said Nomura. (scitechdaily.com)
- The mice that did not have this enzyme disabled rapidly developed tumors. (scitechdaily.com)
Significantly1
- Results: Here, we show that VEGF and EMT markers expression were significantly correlated with depth of tumor invasion and GC stage (P (bvsalud.org)
Immunosuppression1
- Prompt reduction of immunosuppression and initiation of No fungal growth was detected in a cerebrospinal antifungal therapy was required to successfully control fluid sample. (cdc.gov)
Oncogenic1
- Numbers shown below represent number of publications held in OncomiRDB database for Oncogenic and Tumor-Suppressive MicroRNAs. (cancerindex.org)
Metabolism1
- There is increasing interest in the effect of natural compounds, especially food extracts, on the resident oral microflora, both in terms of their ability to promote the growth of beneficial organisms and by their inhibition of the growth and metabolism of species associated with disease 60 . (bvsalud.org)