Cell AgingCyclin-Dependent Kinase Inhibitor p16Tumor Suppressor Protein p53TelomereFibroblastsCell Line, TumorAging, PrematureCyclin-Dependent Kinase Inhibitor p21TelomeraseTelomere Shorteningbeta-GalactosidaseDNA DamageAgingCell ProliferationTumor Suppressor ProteinsCells, CulturedCell Transformation, NeoplasticSignal TransductionCell CycleTumor Markers, BiologicalCell LineNeoplasmsRetinoblastoma ProteinTumor Necrosis Factor-alphaTumor BurdenTumor Suppressor Protein p14ARFCell Cycle CheckpointsGenes, Tumor SuppressorOxidative StressCell DivisionRNA, Small InterferingPhenotypeSirtuin 1Down-RegulationApoptosisGenes, p16Wilms TumorModels, BiologicalGene Expression RegulationLongevityRNA InterferenceDNA-Binding ProteinsProgeriaReactive Oxygen SpeciesMutationNeoplasms, ExperimentalTelomeric Repeat Binding Protein 2DiploidyRNA, MessengerNuclear ProteinsBlotting, WesternMice, Inbred C57BLReverse Transcriptase Polymerase Chain ReactionGene Knockdown TechniquesUp-RegulationNeoplasm ProteinsTranscription FactorsCarcinoid TumorGene Expression Regulation, Neoplasticras ProteinsOncogenesTime FactorsGenes, rasMice, KnockoutHeterochromatinHydrogen PeroxideGene SilencingTransfectionRepressor ProteinsGenes, p53Neuroendocrine TumorsWerner SyndromeBrain NeoplasmsTumor MicroenvironmentCell Cycle ProteinsHCT116 CellsMolecular Sequence DataPromoter Regions, GeneticImmunohistochemistryBase SequenceSkin NeoplasmsCell SurvivalMice, Inbred BALB CMice, NudeCell Line, TransformedProto-Oncogene Proteins c-mycGene ExpressionMammary Neoplasms, ExperimentalTOR Serine-Threonine KinasesGene Expression ProfilingPlant LeavesMice, TransgenicOxidantsTranscription, GeneticFlow CytometryNeovascularization, PathologicNevus, PigmentedProtein-Serine-Threonine KinasesHistonesPhosphorylation