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  • expressed genes
  • Using the Gene Expression Omnibus (GEO) database, we identified up-regulated differentially expressed genes (DEGs) between tumor tissues and nontumor tissues in PDAC patients, enriched potential pathways/biological processes, and evaluated associations between up-regulated DEGs and PDAC outcomes. (bioscirep.org)
  • suppressor protein
  • The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. (wikipedia.org)
  • These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. (wikipedia.org)
  • gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. (wikipedia.org)
  • cells
  • Here we sought to establish a model for the efficient manipulation and transformation of porcine mammary epithelial cells (pMEC) in vitro and tumor growth in vivo . (biomedcentral.com)
  • Little is known about the tumor stem-like cells (TSLCs) isolated from benign tumors. (biomedcentral.com)
  • Here we want to explore the global expression profile of RNA of tumor stem-like cells isolated from MMQ rat prolactinoma cells. (biomedcentral.com)
  • In this study, total RNA was extracted from MMQ cells and MMQ tumor stem-like cells. (biomedcentral.com)
  • Then we used the qRT-PCR to test the result of Microarray, and found VEGFA had a distinct pattern of expression in MMQ tumor stem-like cells. (biomedcentral.com)
  • Finally, CCK-8 was used to evaluate the reaction of MMQ tumor stem-like cells to small interfering RNAs intervention and bevacizumab treatment. (biomedcentral.com)
  • The results of Microarray showed that 566 known RNA were over-expressed and 532 known RNA were low-expressed in the MMQ tumor stem-like cells. (biomedcentral.com)
  • Down-regulation of VEGFA by small interfering RNAs partially decreased cell viability of MMQ tumor stem-like cells in vitro. (biomedcentral.com)
  • Our findings characterize the pattern of RNA expression of tumor stem-like cells isolated from MMQ cells. (biomedcentral.com)
  • VEGFA may act as a potential therapeutic target for tumor stem-like cells of prolactinomas. (biomedcentral.com)
  • Xu [ 11 ] had proved for first time that tumor stem-like cells can be isolated from pituitary adenoma. (biomedcentral.com)
  • Recently, Chen [ 12 ] and Mertens [ 13 ] had further demonstrated that the tumor stem-like cells were existed and identificated in pituitary adenoma. (biomedcentral.com)
  • However, the global expression profile of RNA in tumor stem-like cells (TSLCs) isolated from prolactinoma kept unknown. (biomedcentral.com)
  • Medical treatment is the first choice for prolactinoma [ 2 , 4 , 5 ], which results in limited tumor specimen source, moreover, there are small number of cells available from human prolactinoma postsurgical samples for in vitro experiments. (biomedcentral.com)
  • Therefore, research on characterizing RNAs expression of MMQ tumor stem-like cells will help to lay the foundation for human prolactinoma. (biomedcentral.com)
  • In this study, total RNA was extracted from three classical cultured MMQ cells and three MMQ tumor stem-like cells cultured in serum-free suspension medium containing growth factor. (biomedcentral.com)
  • Given that the expression levels of let-7 members are significantly low in human cancers and cancer stem cells, the major function of let-7 genes may be to promote terminal differentiation in development and tumor suppression. (wikipedia.org)
  • Although several vectors have been developed to express cytotoxic genes via tumor-specific promoters or to selectively replicate in tumor cells, most are taken up and expressed by just a few targeted tumor cells. (jove.com)
  • transition
  • Cyclin A2 is involved in the G2/M transition but it cannot independently form a maturation promoting factor (MPF). (wikipedia.org)
  • Cyclin A has been shown to play a crucial role in the G2/M transition in Drosophila and Xenopus embryos. (wikipedia.org)
  • vivo
  • We further established that lentivirus can be used for oncogenic-transformation of pMEC ex vivo for generating mammary tumors in vivo . (biomedcentral.com)
  • Moreover, Tag-transformed CD140a- and CD140a-CD49f + pMECs developed site-specific tumors of differing histopathologies in vivo . (biomedcentral.com)
  • cancer
  • We demonstrated that SALL1 functions as a tumor suppressor in breast cancer, which is significantly down-regulated in the basal like breast cancer and in estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor 2 (HER2) triple negative breast cancer patients. (springer.com)
  • Our studies revealed that tumor suppression was mediated by recruitment of the Nucleosome Remodeling and Deacetylase (NuRD) complex by SALL1, which promoted cancer cell senescence. (springer.com)
  • With the onset of the AIDS epidemic in the early 1980s, there was a sudden resurgence of KS affecting primarily gay and bisexual AIDS patients,with up to 50% of reported AIDS patients having this tumor-an extraordinary rate of cancer predisposition. (wikipedia.org)
  • Future cancer incidence in sporadic Rb cases is observed with polynomial kinetics, not exactly quadratic as expected because the first mutation must arise through normal mechanisms, and then can be duplicated by LOH to result in a tumour progenitor. (wikipedia.org)
  • survival
  • Currently, few tumor markers have been externally validated to predict the survival of patients with PDAC [ 5 ]. (bioscirep.org)