Tumor clinically. Medical search. Frequent questions

TOKYO & BASKING RIDGE, N.J.-(BUSINESS WIRE)-Topline results from the primary analysis of the ongoing DESTINY-PanTumor02 phase 2 trial showed ENHERTU ® (trastuzumab deruxtecan) demonstrated clinically meaningful progression-free survival (PFS) and overall survival (OS) in previously treated patients across multiple HER2 expressing advanced solid tumors, two secondary endpoints of the trial. (biotech-365.com)
The DESTINY-PanTumor02 phase 2 trial is evaluating the efficacy and safety of ENHERTU in patients with previously treated locally advanced, unresectable or metastatic HER2 expressing solid tumors not eligible for curative therapy, including biliary tract, bladder, cervical, endometrial, ovarian, pancreatic and other cancers. (biotech-365.com)
Gene therapies have been tested for other solid tumors for quite some time - for decades. (medscape.com)
Why and how it is replacing past approaches in the management of solid tumors is the subject of this two-part overview. (cancernetwork.com)
The situation with solid tumors is considerably more complex, and the evolution of targeted therapies for these cancers is still in its infancy. (cancernetwork.com)
At present, and for some years to come, the treatment of most solid tumors will continue to rely on a patchwork of empirically derived and newly introduced molecularly targeted agents. (cancernetwork.com)
This is a first-in-human, Phase 1/2 open-label, multicenter, dose-escalation, safety, pharmacokinetics (PK), and biomarker study of CBX-12 in subjects with advanced or metastatic refractory solid tumors. (bcan.org)
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of escalating doses of RMC-5552 monotherapy in adult participants with relapsed/refractory solid tumors and to identify the recommended Phase 2 dose (RP2D). (bcan.org)
This is an open-label, multicenter, Phase 1/1b study of RMC-5552 monotherapy in participants with advanced relapsed or refractory solid tumors. (bcan.org)
The study will include 2 components: 1) a Dose-Escalation Component for participants with relapsed or refractory solid tumors and 2) a Dose-Expansion Component for participants with relapsed or refractory solid tumors harboring certain specific mutations/rearrangements that result in hyperactivation of the mTOR pathway. (bcan.org)
Janssen is focused on addressing areas of unmet need in both prostate cancer and solid tumors, and this year's ESMO Annual Congress provides an opportunity to share these important study results for both approved and investigational therapies," said Mark Wildgust, Ph.D., Vice President, Global Medical Affairs, Oncology, Janssen Research & Development, LLC. (jnj.com)
Solid Tumors or Hematologic Malignancies within 5 years prior to the screening b. (who.int)

The reasons for tumour recurrence are unknown, and there are currently no effective treatments for aggressive meningiomas, making it essential to improve our understanding of this tumour type. (thebraintumourcharity.org)
Pathologic examination verified the diagnosis of giant cell tumor of tendon sheath, and follow-up magnetic resonance imaging revealed no remnants or recurrence of tumor 1 year after surgery. (japmaonline.org)
Accurate preoperative pathological diagnosis allows correct surgical planning and avoidance of reoperation, either to achieve wider excision or for subsequent tumor recurrence [ 8 - 10 ]. (hindawi.com)
It has been suggested that, in a proportion of fibroadenomas, a somatic mutation can result in a monoclonal proliferation, histologically indistinguishable from the polyclonal element, but with a propensity to local recurrence and progression to a phyllodes tumor which has also been supported by clonal analysis. (hindawi.com)
At four years after surgery, no local recurrence or metastasis has been found clinically. (hindawi.com)
The patient was clinically well without recurrence at three-month post-operative follow-up appointment. (uni-muenster.de)
The Keratocystic Odontogenic Tumor (KOT) is a pathology classified as an odontogenic cyst and began to be considered an odontogenic tumor in 2005, because of the presence of intrinsic characteristics compatible with neoplasm, such as its high rate of recurrence and differentiated mechanism of growth. (bvsalud.org)
Clinically it presents aggressive behavior and high rates of recurrence. (bvsalud.org)
Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. (cancercentrum.se)

The approval of Lutathera was originally based on the pivotal NETTER-1 trial, which demonstrated highly significant and clinically meaningful PFS prolongation for patients treated with Lutathera in combination with long-acting octreotide versus high-dose (60 mg) long-acting octreotide for SSTR-positive, inoperable midgut neuroendocrine tumors (NETs) who were progressing despite standard treatment 3-4,9 . (novartis.com)

In general, overdiagnosis is more common in older individuals and those with otherwise limited life expectancy since the slowly growing lesions associated with overdiagnosed cancers have less time to become clinically apparent in such persons. (cancer.gov)
Phyllodes tumors are rare fibroepithelial lesions. (hindawi.com)
With the nonoperative management of fibroadenomas widely adopted, the importance of phyllodes tumors today lies in the need to differentiate them from other benign breast lesions. (hindawi.com)
We suggest that these ovarian tumors and colonic lesions were also associated with separate endometriotic foci. (hindawi.com)
No apparent transitional lesions were noted between the different tumor components. (hindawi.com)
Findings of other lesions indicates a non-bone primary tumor. (medscape.com)

Although benign tumors only grow in one area, they may still be life-threatening depending on their size and location. (wikipedia.org)

These can be further classified as primary tumors, which start within the brain, and secondary tumors, which most commonly have spread from tumors located outside the brain, known as brain metastasis tumors. (wikipedia.org)
For the most part, treatment for rectal cancer depends on the stage of the tumor-specifically the size and location of the tumor in the rectum as well as the degree of metastasis (how far the tumor may have spread). (hopkinsmedicine.org)
The new prognostic stage groups incorporate grade, estrogen receptor status, progesterone receptor status, and HER2 status, combining these biologic factors with tumor-nodal-metastasis (TNM) categories. (ascopost.com)
The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (cancercentrum.se)
Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary. (cancercentrum.se)
Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? (cancercentrum.se)

Table 1 shows the estimated risk of subclinical disease in patients with clinically negative neck findings as a function of primary site and T stage. (medscape.com)
Based on the findings, the tumors are divided into different grades of severity. (wikipedia.org)
These findings suggest that these tumors arose from separate endometriosis foci and collided within the same ovary. (hindawi.com)
Tumor response to treatment, based on clinical findings, did not correlate well with conventional imaging findings. (ajnr.org)

All types of brain tumors may produce symptoms that vary depending on the size of the tumor and the part of the brain that is involved. (wikipedia.org)
Radiation therapy, alone or in combination with chemotherapy, is often recommended prior to surgery to decrease the size of the tumor and further decrease the need for a colostomy. (hopkinsmedicine.org)

The symptoms experienced are often linked to the location of the tumor, but each person may experience something different. (wikipedia.org)
When the location of the tumor allows for it, surgeons will try to avoid abdominal surgery by using minimally invasive techniques. (hopkinsmedicine.org)

In conclusion, direct injection of primary ependymoma tumor cells played an important role in the generation of a clinically relevant mouse model IC-1425EPN and a novel cell line, BXD-1425EPN. (nih.gov)
A brain tumor occurs when abnormal cells form within the brain. (wikipedia.org)
This treatment had demonstrated some efficacy when put inside the bladder, but largely due to the limited dwell time and the exposure of the interferon protein to the bladder tumor cells, it ultimately did not pan out as an effective treatment choice. (medscape.com)
As has often been the case, hematologic malignancies have led the way in the introduction of this new generation of therapeutics-perhaps because of easy access to tumor samples for pharmacodynamics, and the narrow spectrum of cells of origin. (cancernetwork.com)
however, a tumor consisting entirely of spindle-A cells is considered a nevus. (aao.org)
Tumors composed of a mix of spindle-A and spindle-B melanoma cells are designated spindle cell melanomas . (aao.org)
Seromucinous tumor cells were positive for estrogen receptor (ER) and progesterone receptor (PgR) but negative for Napsin A, p504S, and HNF1B. (hindawi.com)
These tumor cells had clear cytoplasm and a hobnail-shaped appearance (Figure 2(c) ). (hindawi.com)
well as cytologic study for tumour cells. (who.int)
Routine histology revealed a tumor with true rosettes, perivascular pseudorosettes and ependymal canals consistent with ependymoma, but also showed chronic inflammation and abundant distended pigmented tumor cells that mimicked macrophages in frozen and permanent sections. (uni-muenster.de)
The pigmented cells were positive for GFAP and negative for CD163 consonant with glial tumor cells. (uni-muenster.de)
Internal radiotherapy uses a specific agent that links to tumor cells, coupled to a radiotracer for electron-dose delivery. (snmjournals.org)
and tumors of the pancreatic islet cells and/or pituitary gland. (msdmanuals.com)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
Noninvasive Detection of Clinically Significant Prostate Cancer Using Circulating Tumor Cells. (cdc.gov)

There are two main types of tumors: malignant tumors and benign (non-cancerous) tumors. (wikipedia.org)
Outcomes for malignant tumors vary considerably depending on the type of tumor and how far it has spread at diagnosis. (wikipedia.org)
The multiple endocrine neoplasia (MEN) syndromes comprise 4 genetically distinct familial diseases involving adenomatous hyperplasia and malignant tumors in several endocrine glands. (msdmanuals.com)

First line treatment with Lutathera in combination with long-acting octreotide demonstrated a significant improvement in progression-free survival (PFS) in patients with newly diagnosed somatostatin receptor (SSTR)-positive, Grade 2 and 3, advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs) versus high-dose long-acting octreotide alone 1,2 . (novartis.com)
Lutathera ® (INN: lutetium ( 177 Lu) oxodotreotide / USAN: lutetium Lu 177 dotatate) is an Advanced Accelerator Applications RLT approved in the United States for the treatment of SSTR-positive GEP-NETs, including foregut, midgut and hindgut neuroendocrine tumors in adults and in Europe for unresectable or metastatic, progressive, well-differentiated (G1 and G2), SSTR-positive GEP-NETs in adults 1 0 - 1 1 . (novartis.com)
resection is the treatment of choice for primary pancreatic neuroendocrine tumors (PNETs), because it is associated with increased survival. (medscape.com)
For patients with malignant pancreatic neuroendocrine tumors (PNETs), laparoscopy appears not to compromise oncologic resection and offers the advantages of reduced postoperative pain, improved cosmetic results, shorter hospital stay, and a shorter postoperative recovery period. (medscape.com)
Therapeutic options in patients with advanced-stage gastroenteropancreatic (GEP) neuroendocrine tumors are limited. (snmjournals.org)
Therapeutic options in patients with progressive and disseminated metastatic neuroendocrine gastroenteropancreatic (GEP) tumors are often limited, and prognosis is often poor ( 1 , 2 ). (snmjournals.org)

After Treatment, when will my tumor or lesion disappear? (unc.edu)
There was no transitional lesion between the two tumors. (hindawi.com)
Patients who have an isolated lesion or patients in whom the preoperative workup fails to localize the tumor should undergo laparotomy (by an experienced surgeon) with the intent to resect. (medscape.com)

The progression-free survival and overall survival results for ENHERTU alongside the continued robust and durable tumor responses seen with further follow-up underscore the potential value of this important medicine for patients with HER2 expressing cancers who currently have no targeted treatment options," said Cristian Massacesi, MD, Chief Medical Officer and Oncology Chief Development Officer, AstraZeneca. (biotech-365.com)
In the pivotal Phase III trial, vorasidenib, an oral dual inhibitor of mutant IDH1/2 enzymes, elicited an "unprecedented improvement" in progression-free survival with a 61% decrease in tumor growth, according to Servier. (biospace.com)

When this type of tumor grows to a significant size, it may extend beyond its site of origin (ie, from the choroid to the ciliary body and vice versa). (aao.org)

Secondary, or metastatic, brain tumors are about four times as common as primary brain tumors, with about half of metastases coming from lung cancer. (wikipedia.org)
Subjects with primary central nervous system (CNS) tumors or clinically active CNS metastases or carcinomatous meningitis. (bcan.org)

With these results, NETTER-2 is Lutathera's second Phase III trial showing clinically meaningful results for patients 2,4 . (novartis.com)
In an exploratory subgroup analysis of HRD-positive patients, LYNPARZA plus bevacizumab provided a clinically meaningful improvement in OS, reducing the risk of death by 38% (HR=0.62 [95% CI, 0.45-0.85]) versus bevacizumab alone. (merck.com)
Neuroendoscopic biopsy provided meaningful pathological data in 90% of patients, making subsequent tumor therapy feasible. (thejns.org)

DESTINY-PanTumor02 is a global, multicenter, multi-cohort, open-label phase 2 trial evaluating the efficacy and safety of ENHERTU (5.4 mg/kg) for the treatment of HER2 expressing tumors, including biliary tract cancer, bladder cancer, cervical cancer, endometrial cancer, ovarian cancer, pancreatic cancer and other tumors. (biotech-365.com)
Vorasidenib was the lead asset in the package, coming over to the French pharma along with AG-270, an adenosyltransferase 2a (MAT2A) inhibitor being developed for non-small cell lung cancer (NSCLC) and pancreatic cancer, and AG-636, which inhibits dihydroorotate dehydrogenase, a mitochondrial enzyme implicated in tumor progression. (biospace.com)

These data support a model whereby activating MLLT1 mutations early in renal development result in the development of Wilms tumour. (nature.com)
We report in-frame insertion/deletion MLLT1 mutations in FHWT that are absent in other TARGET paediatric tumour types. (nature.com)
We conclude that activating MLLT1 mutations accompanied by Wnt activation early in renal development result in the development of Wilms tumour. (nature.com)
Whole genome sequencing makes it possible to comprehensively discover the mutations, and the mutated genes, that are responsible for tumour formation. (nature.com)
We describe areas where major inroads were initially achieved by targeting angiogenesis and by unraveling pathways in the heterogeneous tumors of mesenchymal origin-spurred by the identification of c-Kit-activating mutations in GIST and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec). (cancernetwork.com)
Here, in Part I, we describe areas where major inroads were initially achieved by targeting angiogenesis (central to the biology of renal cell carcinoma and hepatocellular cancer) and by unraveling pathways in the heterogeneous tumors of mesenchymal origin-spurred by the identification of c-Kit-activating mutations in gastrointestinal stromal tumors (GIST) and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec). (cancernetwork.com)
Tumors were genetically variable, and a similar genetic landscape as previous studies using non-formalin fixed samples was identified, with recurrent mutations including ATM, KMT2D, and TP53. (lu.se)

The most common types of primary tumors in adults are meningiomas (usually benign) and astrocytomas such as glioblastomas. (wikipedia.org)
Primary brain tumors occur in around 250,000 people a year globally, and make up less than 2% of cancers. (wikipedia.org)
Primary and secondary brain tumors present with similar symptoms, depending on the location, size, and rate of growth of the tumor. (wikipedia.org)
Cases without a numeric score, non-squamous cell carcinoma primary tumors, and primary squamous cell carcinoma outside the head and neck were excluded. (ajnr.org)
Incidence and occurrence of second primary tumors. (cancercentrum.se)

A few studies have reported tumors coexisting with SMBTs, such as endometrioid adenocarcinoma [ 4 ] and squamous cell carcinoma [ 5 ]. (hindawi.com)

The value of FNAC in diagnosis of phyllodes tumour remains controversial, but core needle biopsy has high sensitivity and negative predictive value. (hindawi.com)
All 18 patients received external beam radiation at the time of their initial diagnosis after surgical resection of the original tumor. (ajnr.org)
The determination of testosterone in women is helpful in the diagnosis of androgenic syndrome (AGS), polycystic ovaries (Stein-Leventhal syndrome) and when an ovarian tumor, adrenal tumor, adrenal hyperplasia or ovarian insufficiency is suspected. (cdc.gov)

Excisional biopsy revealed a multinodular basaloid tumor, located within the dermis and subcutaneous fat that extended into skeletal muscle at the deep and peripheral margin. (karger.com)
In all patients, a neuroendoscopic tumor biopsy was performed. (thejns.org)
In addition to the tumor biopsy, 32 patients (53%) underwent endoscopic third ventriculostomy (ETV), and 7 (12%) underwent septum pellucidotomy. (thejns.org)

Eleftheriadis N, Inoue H, Ikeda H, Onimaru M, Maselli R, Santi G. Submucosal tunnel endoscopy: Peroral endoscopic myotomy and peroral endoscopic tumor resection. (wjgnet.com)

Limited availability of in vitro and in vivo model systems has hampered efforts to understand tumor biology and test novel therapies for ependymoma, the third most common malignant brain tumor that occurs in children. (nih.gov)
Using CUDA , GTX 1080 GPUs and cuDNN with the Theano deep learning framework to train their models, Orringer and his team are able to predict brain tumor subtype with 90 percent accuracy. (nvidia.com)

ESMO guidelines recommend specifying the tumor type and subtype according to the 2013 World Health Organization (WHO) classification. (medscape.com)

The majority of phyllodes tumors have been described as benign (35% to 64%), with the remainder divided between the borderline and malignant subtypes. (hindawi.com)

An adequate tumor sample must be available from core needle biopsies obtained during the Screening Period and following the subject's most recent systemic therapy. (bcan.org)
The raw bioassays are derived from 20 samples (the biopsies) annotated with a number of biologically and clinically relevant annotations, e.g., lung cancer type, tumor size, and so on. (lu.se)

In contrast, benign phyllodes tumors on clinical, radiological, and cytological examination are often indistinguishable from fibroadenomas and can be cured by local surgery. (hindawi.com)
Treatment plans are then based upon the clinical stage of your tumor. (hopkinsmedicine.org)
The intent was to treat all patients because of uncontrolled tumor disease ( n = 21), contraindication to chemotherapy or surgery ( n = 7), or uncontrolled and badly tolerated clinical symptoms ( n = 4). (snmjournals.org)
Pejorative events were defined as side effects due to therapy, relapse in clinical symptoms, tumor progression, tumor laboratory marker increase, and death. (snmjournals.org)
Dynamic, contrast-enhanced MR imaging is a valuable adjunct to conventional imaging in assessing tumor activity during antiangiogenic therapy, and correlates better than conventional studies with clinical status and response to therapy. (ajnr.org)

In 1981 [ 6 ] the World Health Organization adopted the term phyllodes tumor and as described by Rosen [ 7 ] subclassified them histologically as benign, borderline, or malignant according to the features such as tumor margins, stromal overgrowth, tumor necrosis, cellular atypia, and number of mitosis per high power field. (hindawi.com)
Prostate tumors are among the most heterogeneous of cancers, both histologically and clinically. (nih.gov)
Subject has a histologically- or cytologically-diagnosed solid tumor which is advanced or metastatic and which has progressed on or following at least one systemic therapy regimen administered for advanced or metastatic disease or for which no approved therapy exists. (bcan.org)

Tumors arising from some sites (eg, oral tongue) may occasionally skip level II lymph nodes and metastasize to level III or IV lymph nodes. (medscape.com)
If the metastatic nodes significantly obstruct the lymphatic trunks, patients who have clinically positive lymph nodes on the ipsilateral side of the neck may be at risk for contralateral lymph node spread. (medscape.com)

Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids. (who.int)
Mayr D, Hirschmann A, Marlow S, Horvath C, Diebold J. Analysis of selected oncogenes (AKT1, FOS, BCL2L2, TGFbeta) on chromosome 14 in granulosa cell tumors (GCTs): a comprehensive study on 30 GCTs combining comparative genomic hybridization (CGH) and fluorescence-in situ-hybridization (FISH). (cancercentrum.se)

Chemotherapy reduces tumor size and improves the symptoms secondary to metastatic effects of the tumor. (medscape.com)
With advances in adjuvant chemotherapy, patients with malignant gliomas are living longer and there is a need for more sophisticated imaging surveillance of tumor progression. (ajnr.org)
Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)

RARITAN, N.J., September 17, 2019 - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today multiple data presentations from its prostate cancer and solid tumor portfolios will be featured at the European Society for Medical Oncology (ESMO) Annual Congress 2019, taking place September 27 to October 1 in Barcelona, Spain. (jnj.com)

Bladder tumors in two young males occupationally exposed to MBOCA. (cdc.gov)
The case studies of bladder tumors occurring in two young men occupationally exposed to 4,4'-methylenebis(2-chloroanaline) (101144) (MBOCA) were reported. (cdc.gov)

After treatments patients typically are asked to get periodic images ( CT Scan or MRI) of their tumor(s) so that their physician can monitor the effectiveness of the radiation. (unc.edu)
NETTER-2 (NCT03972488) is an open-label, multi-center, randomized, comparator-controlled Phase III trial assessing whether Lutathera plus long-acting octreotide when taken as a first line treatment can prolong PFS in patients with high-proliferation rate tumors (G2 and G3), compared to treatment with high-dose (60 mg) long-acting octreotide 2 . (novartis.com)
These results support a clinically-relevant phenomenon of shaping of the IFN signature by IRF4 in autoimmune patients. (frontiersin.org)
Advanced imaging techniques allows surgeons to evaluate the size and depth of the tumor before surgery to determine which patients would benefit from presurgical treatment. (hopkinsmedicine.org)
Closely monitor patients at risk and treat as clinically indicated. (nih.gov)
Roughly half of patients with advanced ovarian cancer have homologous recombination deficiency (HRD)-positive tumors, including those with a BRCA mutation, and one in four women have a BRCA mutation. (merck.com)
Many HER2-positive tumors are downstaged with this current system, because the prognosis of these patients in the HER2-targeted era is better. (ascopost.com)
However, the excellent long-term survival in patients with less complicated surgeries and the increased morbidity and mortality associated with the Whipple procedure make its general utility still unclear and it is recommended primarily for large, advanced tumors. (medscape.com)
Radionuclide therapy is feasible and safe and significantly defers the occurrence of fatal and nonfatal events in patients clinically uncontrolled by conventional therapy. (snmjournals.org)
Because 111 In emits short-range electrons that can have significant biologic effects at a cellular level ( 17 - 19 ), radionuclide therapy with a high activity of 111 In-pentetreotide has been used in a few patients with GEP tumors ( 5 , 20 - 30 ). (snmjournals.org)
We report the results of radionuclide therapy with either 111 In-pentetreotide or 131 I-MIBG in a population of patients with advanced-stage GEP tumors. (snmjournals.org)
Sixty patients with newly diagnosed intraventricular and paraventricular tumors were included. (thejns.org)
Patients in the vorasidenib arm had a median of 27.7 months before their tumors progressed compared to 11.1 months for those on placebo. (biospace.com)
Association of Axillary Dissection With Systemic Therapy in Patients With Clinically Node-Positive Breast Cancer. (bvsalud.org)
Importance The role of axillary lymph node dissection (ALND) to determine nodal burden to inform systemic therapy recommendations in patients with clinically node (cN)-positive breast cancer (BC) is currently unknown. (bvsalud.org)
Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)

THE RECENTLY issued 8th revision to the American Joint Committee on Cancer (AJCC) Breast Cancer Staging System incorporates tumor biology and prognostic stage groups and thus has become more accurate and clinically relevant, according to two speakers at the 2018 Miami Breast Cancer Conference. (ascopost.com)

The term phyllodes tumor represents a broad range of fibroepithelial diseases and presence of an epithelial component with stromal components differentiates the phyllodes tumor from other stromal sarcomas. (hindawi.com)
It has also been postulated that stromal induction of phyllodes tumors can occur as a result of growth factors produced by the breast epithelium. (hindawi.com)

The cause of most brain tumors is unknown, though up to 4% of brain cancers may be caused by CT scan radiation. (wikipedia.org)
While HER2 directed therapies have been used to treat breast, gastric, lung and colorectal cancers, more research is needed in evaluating their potential in treating other HER2 expressing tumor types. (biotech-365.com)
By sequencing pairs of normal and tumour genomes from large patient cohorts, projects such as the ICGC (International Cancer Genome Consortium) and TCGA (The Cancer Genome Atlas) aim to create definitive driver mutation catalogues for all common cancers 1 , 2 . (nature.com)
Overdiagnosis, which occurs when screening procedures detect cancers that would never become clinically apparent in the absence of screening. (cancer.gov)
When stage I tumors can't be removed through the rectum, it may be necessary to use more invasive surgical techniques, which are more common for stage II and stage III rectal cancers. (hopkinsmedicine.org)
For each cancer discussed in the first part of our overview, as well as in Part II, which will deal with more common cancers, we briefly cover the tumor biology, how targeting was achieved, the introduction of immune modulation or immune-conjugates, and the impact these therapies are having in the disease. (cancernetwork.com)

The prevalence of tumor involvement and the probability of capsular penetration increase with lymph node size. (medscape.com)

The signs and symptoms of brain tumors are broad. (wikipedia.org)
People may experience symptoms regardless of whether the tumor is benign (not cancerous) or cancerous. (wikipedia.org)

Dexamethasone and furosemide are medications that may be used to decrease swelling around the tumor. (wikipedia.org)

Early infiltrates were most prominent in the tumour and upper dermis. (nih.gov)

TBL is classified in the latest skin tumor classification by the World Health Organization as one with a favorable outcome. (karger.com)

Research led by a team at the University of California San Francisco and California State University Channel Islands has uncovered a genetic driver associated with clinically aggressive meningiomas. (thebraintumourcharity.org)
The researchers analysed 280 transcription factors from 261 tumour samples gathered from individuals with meningiomas. (thebraintumourcharity.org)
To learn more about meningiomas and research into this tumour type, read Dr Gelareh Zadeh's project to target clinically challenging meningiomas . (thebraintumourcharity.org)

[ 2 ] Base the treatment on factors related to ulcer disease, diarrhea, and malignant properties of the tumor. (medscape.com)
MIBG can be labeled with 131 I, which has a long half-time (8 d) and a maximal electron range of about 2.4 mm and is established in the treatment of tumors derived from the neural crest, such as GEP tumors ( 11 ). (snmjournals.org)

Some localized melanomas may result from azathioprine, which acts synergistically with ultraviolet radiation, while T-cell depleting induction therapies may promote late stage tumors. (cdc.gov)

Initially, we developed this technology as a means of helping surgeons detect microscopic tumor, but we found the technology was capable of much more than guiding surgery. (nvidia.com)

Breast tumor biology is critically important. (ascopost.com)

Nuclear stratification was noted, but no invasive growth was apparent in these cystic tumors. (hindawi.com)

Originally described by Headington in the 1970s, trichoblastoma (TBL) is now appreciated as a rare benign tumor that originates from the follicular germ cell line [1, 2]. (karger.com)
Pauniaho SL, Salonen J, Helminen M, Vettenranta K, Heikinheimo M, Heikinheimo O. The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland. (cancercentrum.se)
Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)

Interrupt HERZUMA infusion for dyspnea or clinically significant hypotension . (rxlist.com)
Clinically significant intercurrent disease. (bcan.org)
In no case did clinically significant sequelae affect the patient's outcome. (thejns.org)
The difference in rCBV values between the clinically stable and the progressive group at 12-month follow-up was statistically significant, with the progressive group having higher values. (ajnr.org)
Lesser, who was not involved in the study, called the results "clinically very significant and important. (biospace.com)
Cognitive disorder, Alzheimer's disease or mental illness be clinically significant. (who.int)

the full TARGET high-risk Wilms tumour data, including 125 tumours (both favourable histology and anaplastic tumours) and including verified variants present at lower frequencies, will be reported in full when these data become available. (nature.com)

These tumors may exhibit variable amounts of necrosis. (aao.org)

They make up 0.3 to 0.5% of female breast tumors [ 1 ] and have an incidence of about 2.1 per million, the peak of which occurs in women aged 45 to 49 years [ 2 , 3 ]. (hindawi.com)

Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K. Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases. (cancercentrum.se)

The permanent cell line (BXD-1425EPN), which was derived from a passage II xenograft tumor and has been passaged in vitro more than 70 times, expressed similar differentiation markers of the xenograft tumors, maintained identical chromosomal abnormalities, and formed tumors in the brains of SCID mice. (nih.gov)
While no expression correlates of age, serum prostate specific antigen (PSA), and measures of local invasion were found, a set of genes was identified that strongly correlated with the state of tumor differentiation as measured by Gleason score. (nih.gov)

To develop clinically relevant animal models of ependymoma, we directly injected a fresh surgical specimen from a 9-year-old patient into the right cerebrum of RAG2/severe complex immune deficiency (SCID) mice. (nih.gov)

B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)

Our pipeline, ExInAtor, identifies genes with excess load of somatic single nucleotide variants (SNVs) across panels of tumour genomes. (nature.com)
We have presented a first catalogue of mutated lncRNA genes driving cancer, which will grow and improve with the application of ExInAtor to future tumour genome projects. (nature.com)
CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)

Ovarian seromucinous borderline tumors (SMBTs) are rare. (hindawi.com)
They architecturally resemble serous borderline tumors but are much more frequently associated with endometriosis. (hindawi.com)
Seromucinous borderline tumors (SMBTs) are characterized by papillary architecture reminiscent of serous tumors but composed of mucinous epithelium similar to that of the endocervix. (hindawi.com)
SMBTs have been considered a subset of mucinous tumors and account for 15% of all mucinous borderline tumors [ 1 ]. (hindawi.com)

It has been reported that Whipple pancreaticoduodenectomy affords the greatest probability for cure, particularly for multiple endocrine neoplasia type I (MEN I)-associated gastrinomas, although also for sporadic tumors, because it results in the removal of the entire gastrinoma triangle. (medscape.com)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)

Sixteen adults with clinically diagnosed BCC were openly assigned to 5 days per week of drug (1, 2 or 4 weeks) or placebo (2 weeks) in groups of four. (nih.gov)

Anatomy14

Organisms10

Diseases98

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes47

Disciplines and Occupations1

Information Science4

Health Care9

Solid Tumors12

Recurrence9

Demonstrated highly significant an1

Lesions6

Benign tumors1

Metastasis6

Findings4

Size of the tumor2

Location of the tumor2

Cells16

Malignant tumors3

Neuroendocrine6

Lesion3

Progression-free sur2

Type of tumor1

Metastases2

Meaningful3

Pancreatic2

Mutations7

Primary5

Squamous cell carc1

Diagnosis3

Biopsy3

Resection1

Brain tumor2

Subtype1

Described as benign1

Biopsies2

Clinical5

Histologically3

Lymph nodes2

Genomic2

Chemotherapy3

Prostate Cancer1

Bladder2

Patients16

Staging System1

Stromal2

Cancers6

Prevalence1

Symptoms2

Decrease1

Dermis1

World Health Organ1

Meningiomas3

Treatment2

Therapies1

Microscopic1

Biology1

Cystic1

Germ3

Significant6

Tumours1

Necrosis1

Incidence1

Adult1

Differentiation2

Ependymoma1

Therapeutic1

Genes3

Borderline4

Results2

Adults1