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CholangiocarcinomaBile Duct NeoplasmsBile Ducts, IntrahepaticAdenoma, Bile DuctKlatskin's TumorBile Ducts, ExtrahepaticOpisthorchisOpisthorchiasisCell Line, TumorTumor Markers, BiologicalBiliary Tract Surgical ProceduresLiver NeoplasmsTumor BurdenHepatic Duct, CommonCholangitis, SclerosingHepatectomyTumor Necrosis Factor-alphaLithiasisClonorchiasisFascioliasisBile DuctsCell ProliferationFasciola hepaticaClonorchis sinensisThailandTumor Suppressor Protein p53Cholangiopancreatography, Endoscopic RetrogradeNeoplasms, ExperimentalCarcinoma, HepatocellularGallbladder NeoplasmsWilms TumorRetrospective StudiesJaundice, ObstructiveBiliary Tract NeoplasmsPrognosisTreatment OutcomeImmunohistochemistryGenes, Tumor SuppressorCA-19-9 AntigenCholangitisSurvival RateNeoplasm StagingCarcinoid TumorMice, NudeTumor Suppressor ProteinsGene Expression Regulation, NeoplasticNeoplasm MetastasisAdenocarcinomaNeuroendocrine TumorsXenograft Model Antitumor AssaysTransplantation, HeterologousLymphatic MetastasisDrainageNeoplasm ProteinsCholangiopancreatography, Magnetic ResonanceKaplan-Meier EstimateBrain NeoplasmsMice, Inbred BALB CTumor MicroenvironmentThioacetamideIridium RadioisotopesSurvival AnalysisApoptosisTime FactorsCholangiographyMammary Neoplasms, ExperimentalSignal TransductionFood ParasitologyPortal VeinDisease ProgressionTomography, X-Ray ComputedLiver TransplantationNeovascularization, PathologicDNA, NeoplasmAntigens, NeoplasmCholedochal CystPalliative CareNeoplasms, Multiple PrimaryCell Transformation, NeoplasticReverse Transcriptase Polymerase Chain ReactionCell DivisionRNA, MessengerNeoplasm Invasiveness
MicroenvironmentHilarSuppressorPancreaticPerihilar cholangiocarcinomaTreatment of cholangiocarcinomaCancerProgressionResectionHepatocellularKlatskinCancersAbstractBile duct tumorsTissuesGenesRecurrencePrognosisPrimary tumorRisk of cholangiocarcinomaIntrahepatic tumorsLymphocytesMetastatic cholangiocarcinomaMacrophagesExtrahepatic cholangiocarcinomasMetastasisRemoval of the tumorPatientsSurvivalOutcomesMalignant tumorSymptomsBiopsyUnresectableMalignanciesLesionsLungSolid TumorTherapeuticHepaticSurgicalTherapyEpitheliumAdenocarcinomasStomachMalignancyExtracellularAnatomical location
Microenvironment12
  • Advances in immunotherapy have shed greater focus on the role of tumor-infiltrating immune cells, which are vital components of the tumor immune microenvironment (TIME). (aging-us.com)
  • TP53 mutations are also associated with the infiltration of immune cells into the tumor microenvironment [ 10 - 12 ]. (aging-us.com)
  • Immune cells in the tumor microenvironment play important roles in cancer development. (bmj.com)
  • 5 Tumor-associated macrophages (TAMs) are present the tumor microenvironment of many cancers, where they play a key role in tumor initiation and progression by activating and maintaining cancer-related inflammation. (bmj.com)
  • The Qadan laboratory focuses on the tumor microenvironment in pancreas cancer. (massgeneral.org)
  • Additionally, characterization of the tumor microenvironment such as interactions with immune cells remain largely unknown. (springer.com)
  • Apart from CSCs, there are a myriad of factors and interactions between various cell types and the tumor microenvironment (TME) that ultimately affect CCA progression. (springer.com)
  • Although RT is an important modality for cancer treatment, the consequential changes caused by RT in the tumor microenvironment (TME) have not yet been fully elucidated. (nature.com)
  • Furthermore, inflammatory mediators released by irradiated dying cells can attract and regulate immune cells in the tumor microenvironment (TME), further killing cancer cells. (nature.com)
  • Tumor purity-related coexpression factors in the tumor microenvironment have essential clinical, genomic, and biological significance in lung cancer. (hindawi.com)
  • Tumor microenvironment possesses complexity because of a mixture of growth-promoting and inhibiting growth factors, nutrients, chemokines, and other noncancer types, which interact with each other and associate with tumor growth, disease progression, drug resistance, and especially, infiltrating T lymphocytes and tumor growth [ 2 ]. (hindawi.com)
  • We explored the coexpression factors most related to tumor purity and related biological functions and demonstrated the most relevant biological functions and mechanism of action affecting tumor purity in the lung cancer tumor microenvironment. (hindawi.com)
Hilar9
Suppressor3
  • The Hepatobiliary Cancer Lab has shown that SULF1 can have both tumor suppressor and oncogenic effects, while SULF2 has primarily oncogenic effects. (mayo.edu)
  • This gene is regarded as a potential tumor suppressor gene. (cancerindex.org)
  • Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits. (nih.gov)
Pancreatic5
  • Current scientific and translational efforts in his laboratory include the evaluation of the radiosensitizing effects of Losartan and introduction of Fingolimod (sphingosine-1-phosphate receptor 1 antagonist) for endothelial barrier disruption in orthotopic pancreatic tumor models. (massgeneral.org)
  • Background: The prevalence of different periampullary cancers (pancreatic ductal adenocarcinoma, distal cholangiocarcinoma, ampullary cancer and duodenal cancer) is heterogeneous in the literature. (lu.se)
  • Among patients treated with pancreatoduodenectomy, diagnosis was pancreatic ductal adenocarcinoma in 1380 (50.0 per cent), distal cholangiocarcinoma in 284 (10.3 per cent), ampullary cancer in 376 (13.6 per cent), duodenal cancer in 160 (5.8 per cent) and other diagnoses in 560 (20.3 per cent) patients. (lu.se)
  • The preoperative diagnosis corresponded to the postoperative in 1177 (67.5 per cent) patients for pancreatic ductal adenocarcinoma, 162 (37.4 per cent) patients for distal cholangiocarcinoma, 220 (61.3 per cent) patients for ampullary cancer and 120 (53.6 per cent) patients for duodenal cancer. (lu.se)
  • The coverage decision for F1CDx dramatically expands on current profiling and will provide information for tumors where mutational testing is not common, such as pancreatic and prostate cancer. (medscape.com)
Perihilar cholangiocarcinoma3
  • Bismuth classification for perihilar cholangiocarcinoma. (medscape.com)
  • Cholangiocarcinoma can be divided into three types according to the original position: Intrahepatic Cholangiocarcinoma (ICC), Perihilar Cholangiocarcinoma (PCC), and Distal Extrahepatic Tumors (DET). (news-medical.net)
  • With the continuous accumulation of laparoscopic radical resection for perihilar cholangiocarcinoma (PHC), the safety and feasibility have been confirmed, and some studies have shown that considering the comparable long-term prognosis and short-term outcomes of laparoscopic surgery and open surgery, laparoscopic surgery could be a technically feasible surgical method for PHC patients of all Bismuth -Corlette types. (bvsalud.org)
Treatment of cholangiocarcinoma3
  • The Hepatobiliary Cancer Lab is identifying and characterizing fibroblast growth factor receptor family gene aberrations and determining the effectiveness of targeting the aberrations in the treatment of cholangiocarcinoma. (mayo.edu)
  • As most patients present with non resectable disease at the time of diagnosis, palliative modalities have a crucial role in the treatment of cholangiocarcinoma. (nursingcenter.com)
  • Update on the Diagnosis and Treatment of Cholangiocarcinoma. (medscape.com)
Cancer34
  • Each year, approximately 2500 cases of cholangiocarcinoma occur, compared with 5000 cases of gallbladder cancer and 15,000 cases of hepatocellular cancer. (medscape.com)
  • Cholangiocarcinoma accounts for approximately 2% of all cancer diagnoses, with an overall incidence of 1.2/100,000 individuals. (wikipedia.org)
  • Cholangiocarcinoma (CC), the most lethal type of liver cancer, remains very difficult to treat due to an incomplete understanding of the cancer initiation and progression mechanisms and no effective therapeutic drugs. (ijbs.com)
  • Circulating tumor cells (CTCs) in blood are associated with poor survival of patients with breast, prostate, or colon cancer. (johnshopkins.edu)
  • Cholangiocarcinoma, or bile duct cancer, occurs when a malignant (cancerous) tumor grows in one of the ducts that transport bile from the liver to the small intestine. (hopkinsmedicine.org)
  • Background Tumor-associated neutrophils (TANs) and macrophages (TAMs) can each influence cancer growth and metastasis, but their combined effects in intrahepatic cholangiocarcinoma (ICC) remain unclear. (bmj.com)
  • Intrahepatic cholangiocarcinoma (ICC) is a cancer of the bile ducts that accounts for around 10%-15% of all primary hepatic malignancies. (bmj.com)
  • The Hepatobiliary Cancer Lab is testing the effectiveness of the novel CK2 inhibitor, CX-4945, on cholangiocarcinoma. (mayo.edu)
  • To improve our understanding of longstanding disparities in incidence and mortality in lung cancer across ancestry, we performed a systematic comparative analysis of molecular features in tumors from African Americans (AAs) and European Americans (EAs). (nature.com)
  • In The Cancer Genome Atlas, we demonstrate that high genomic instability, HRD and chromothripsis among tumors from AAs is found across many cancer types. (nature.com)
  • Cholangiocarcinoma is an aggressive type of liver cancer with few effective treatment options. (springer.com)
  • Here, we employ a fluorescent reporter system to track and isolate stem-like cancer cells of cholangiocarcinoma cell lines. (springer.com)
  • Cholangiocarcinoma (CCA) is an aggressive type of liver cancer, which arises from the epithelium of the biliary tract. (springer.com)
  • Cancer stem cells (CSCs) represent a small subset of the tumor population and reside at the apex of the hierarchy [ 9 ]. (springer.com)
  • It never occurred to me that these symptoms might also be caused by a rare bile duct cancer called intrahepatic cholangiocarcinoma. (ascopost.com)
  • Although the operation went well, and we were optimistic that the cancer was gone, 3 months later, imaging scans found tumors in both my lungs. (ascopost.com)
  • One night, while paying medical bills online, I happened upon a clinical trial that Steven A. Rosenberg, MD, PhD, Chief of the Surgery Branch at the National Cancer Institute (NCI), had launched to investigate whether tumor-infiltrating lymphocyte therapy could be effective for patients with various types of metastatic cancer. (ascopost.com)
  • These nontumor cells dilute the tumor purity in lung cancer tissues. (hindawi.com)
  • Tumor purity plays an essential role in the immune response to lung cancer. (hindawi.com)
  • At present, the biological processes related to the purity of lung cancer tumors remains unclear. (hindawi.com)
  • A lung cancer tumor purity correlated coexpression network was determined. (hindawi.com)
  • We are now aware that lung cancer tissues are rich in nontumor cells, of which stromal cells significantly regulate tumor proliferation, invasion, and angiogenesis [ 6 ]. (hindawi.com)
  • With the development of bioinformatics in recent years and the acquisition of open lung cancer cohorts, it becomes possible to evaluate tumor purity content in the samples according to the estimated infiltration of stromal and immune cells ESTIMATE algorithm [ 7 ]. (hindawi.com)
  • I was diagnosed with cholangiocarcinoma, a fairly rare and aggressive form of cancer. (wxyz.com)
  • This is COOL SCIENCE: Cristae inside mitochondria (purple) align themselves to keep "feeding" certain lung cancer tumors. (cancer.org)
  • Overexpression is more frequently observed in extrahepatic cholangiocarcinomas and gallbladder cancer, for example. (medpagetoday.com)
  • For tumor type, 51% had gallbladder cancer, 29% had intrahepatic cholangiocarcinoma, and 20% had extrahepatic cholangiocarcinoma. (medpagetoday.com)
  • Living with cholangiocarcinoma (a type of bile duct cancer) or bladder cancer? (clinicalconnection.com)
  • For information about bile duct cancer, see Bile Duct Cancer (Cholangiocarcinoma) Treatment. (oncolink.org)
  • Singal AK, Vauthey JN, Grady JJ, Stroehlein JR. Intra-hepatic cholangiocarcinoma--frequency and demographic patterns: thirty-year data from the M.D. Anderson Cancer Center. (medscape.com)
  • Impact of Integrated PET and CT on staging and management of glabladder cancer and cholangiocarcinoma. (medscape.com)
  • Azmi is a 52-year-old man from Deir Al-Balah in the Gaza Strip, who was recently diagnosed with a cancer called a cholangiocarcinoma. (who.int)
  • Subsequent investigations showed that the cause of his symptoms was a cancer in his bile duct, and he had an initial intervention to remove obstruction of the duct by the tumour. (who.int)
  • 3. The following BTC histologic subtypes are excluded: small cell cancer, neuroendocrine tumors, lymphoma, sarcoma, mixed tumor histology, and mucinous cystic neoplasms detected in the biliary tract region. (who.int)
Progression5
  • Functional enrichment analysis of the DEGs in the high OSM-expressing CCA tissues showed that pathways related to tumor progression and immune response were significantly upregulated. (aging-us.com)
  • Interaction between TANs and TAMs enhanced the proliferation and invasion abilities of ICC cells in vitro and tumor progression in a mouse xenograft model of ICC. (bmj.com)
  • 1 2 Immune cells can produce an antitumor immune response and directly kill malignant cells, but they can also be recruited and retrained by tumor cells to facilitate tumor growth and progression. (bmj.com)
  • 1 6 In addition, there is increasing evidence that tumor-associated neutrophils (TANs) support tumorigenesis by promoting oncogenic transformation and tumor progression. (bmj.com)
  • The lab's research team is determining whether this effect contributes to tumor progression and will further explain the related underlying mechanisms. (mayo.edu)
Resection6
  • Complete surgical resection is the only therapy to afford a chance of cure for cholangiocarcinoma. (medscape.com)
  • Complete resection of the tumor, especially in early-stage disease, offers hope of long-term survival. (wikipedia.org)
  • The type of surgery and the extent of the resection depend on the location of the tumor and the degree of extension. (wikipedia.org)
  • If diagnosed early these can be resected, but most cases of intrahepatic cholangiocarcinoma present late in the disease course where surgical resection is not an option. (mdpi.com)
  • and many patients survive several years after tumor resection. (msdmanuals.com)
  • The technical difficulties and surgical key points of laparoscopic radical resection for perhilar cholangiocarcinoma]. (bvsalud.org)
Hepatocellular3
  • Dr. Roberts and his research team are studying SULF inhibitors to treat hepatocellular carcinoma and SULF1/2 roles in cholangiocarcinoma. (mayo.edu)
  • The cover for issue 52 of Oncotarget features Figure 1, "Volcano plots of DNA methylation in tumor tissues compared with nontumor tissue," published in "Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma" by Morine, et al. (news-medical.net)
  • which reported that the authors conducted a genome-wide analysis of DNA methylation of the tumor and non-tumor tissue of 15 patients with Hepatocellular carcinoma (HCC), and revealed TBX15 was the most hypermethylated gene of the tumor. (news-medical.net)
Klatskin4
  • The disease was named after Gerald Klatskin, who in 1965 described 15 cases and found some characteristics for this type of cholangiocarcinoma The cause of cholangiocarcinoma has not been defined. (wikipedia.org)
  • citation needed] Levels of the tumor markers carbohydrate antigen 19-9 (CA 19-9), carcinoembryonic antigen (CEA) and CA 125 are abnormally high in the bloodstreams of patients with intrahepatic cholangiocarcinoma and Klatskin tumor. (wikipedia.org)
  • citation needed] Approximately 15,000 new cases of liver and biliary tract carcinoma are diagnosed annually in the United States, with roughly 10% of these cases being Klatskin tumors. (wikipedia.org)
  • Cholangiocarcinomas occur predominantly in the extrahepatic bile ducts: 60 to 70% in the perihilar region (Klatskin tumors), about 25% in the distal extrahepatic ducts, and the rest in the liver. (merckmanuals.com)
Cancers7
  • Recent studies demonstrate that somatic mutations in the tumor tissues influence immunotherapeutic response in several cancers [ 6 , 7 ]. (aging-us.com)
  • Arsenic (As) is a prevalent toxicant with established associations with bladder, skin and lung cancers while pilot data on its potential carcinogenic role on digestive tumors are emerging. (lww.com)
  • A novel inhibitor of casein kinase 2 (CK2) has shown preliminary evidence of efficacy in patients with locally advanced or metastatic cholangiocarcinoma, according to a phase I/IIb study presented at the 2021 Gastrointestinal Cancers Symposium. (ascopost.com)
  • Chapter 32 Gastrointestinal Cancers DIAGNOSIS TREATMENT DIAGNOSITC IMAGING MEDICATIONS CT scan, MRI, labeled somatostatin receptor-based diagnostic imaging ▪ Localization, TNM staging ▪ Presence of hepatic lesions SURGERY Endoscopy with biopsy ▪ Tumor visualization ▪ Histopathological analysis, grading ▪ Somatostatin analogues suppress tumor proliferation, decrease symptoms ▪ Surgical removal of tumor LAB RESULTS ▪ 5-hydroxyindoleacetic acid, chromogranin Figure 32.2 Gross pathology of carcinoid tumor of the terminal ileum. (osmosis.org)
  • Cholangiocarcinoma (CCA) is considered as a diverse group of epithelial cancers characterized by poor outcomes. (news-medical.net)
  • The present study sought to provide information about periampullary cancers with regard to tumour types in curative and noncurative settings, preoperative diagnostic accuracy and the impact of a standardized evaluation of the surgical specimen on diagnosis, R status and lymph node assessment. (lu.se)
  • [ 1 ] This coverage decision is the culmination of widespread enthusiasm for precision oncology-heightened by the first tissue agnostic approval-the use of pembrolizumab in MSI-high solid tumors, and by reports of dramatic response in diverse cancers to a tropomyosin receptor kinase inhibitor. (medscape.com)
Abstract1
Bile duct tumors2
  • An MRI is slightly superior to a CT scan for visualizing bile duct tumors. (hopkinsmedicine.org)
  • Gallbladder and bile duct tumors can cause extrahepatic biliary obstruction. (merckmanuals.com)
Tissues7
  • We demonstrated that CXCL5 was overexpressed in ICC cell lines and tumor samples compared with paired normal tissues. (nih.gov)
  • CCA patients with a higher proportion of neutrophils and T-regulatory cells (Tregs) and lower proportion of CD8 + T cells in the tumor tissues are associated with poor prognosis [ 5 ]. (aging-us.com)
  • However, only limited types of tumor-infiltrating immune cells have been analyzed in CCA tissues and the mechanisms regulating the tumor infiltration of immune cells are poorly understood. (aging-us.com)
  • Finally, we validated our results in a tissue microarray composed of primary tumor tissues from 359 patients with ICC. (bmj.com)
  • Traditionally, CSCs are identified through a combination of surface markers, however, there is a lack of consensus among the scientific community, especially as these combinations appear to be specific to the corresponding tissues and tumors. (springer.com)
  • We measured tumor purity in 486 lung carcinoma tissues from TCGA-LUAD FPKM by using the "estimate" R package. (hindawi.com)
  • MAGEH1 expression was downregulated in HCC tumor tissues compared with adjacent normal liver tissues and in samples from patients with tumor recurrence. (nih.gov)
Genes4
  • Fusions of fibroblast growth factor receptor genes with other partner genes were recently discovered in cholangiocarcinoma. (mayo.edu)
  • The prevalence of germline HRD (that is, the total number of pathogenic variants in homologous recombination genes) is higher in tumors from AAs, suggesting that the somatic differences observed have genetic ancestry origins. (nature.com)
  • Five coexpressed genes (CD4, CD53, EVI2B, PLEK, and SASH3) were identified as tumor purity coexpressed genes that negatively correlated with tumor purity. (hindawi.com)
  • Using GSEA analysis, we found that the antigen processing and presentation pathway were related to the five tumor coexpressed genes mentioned above. (hindawi.com)
Recurrence2
  • Immunohistochemical analysis of ICC samples showed that overexpression of CXCL5 correlated strongly with intratumoral neutrophil infiltration, shorter overall survival and high tumor recurrence. (nih.gov)
  • Tumor necrosis and grade of fibrosis were assessed histologically and correlated with clinicopathological characteristics, tumor recurrence, and patients' survival. (qxmd.com)
Prognosis1
Primary tumor2
  • 1 Carcinoma of the colon is the most common primary tumor site associated with metastases to an inguinal hernia. (ispub.com)
  • 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 There are previous reports of biliary tract disease metastastic to a hernia sac, but none of them has the gallbladder as a primary tumor. (ispub.com)
Risk of cholangiocarcinoma1
  • Obesity and the risk of cholangiocarcinoma: a meta-analysis. (medscape.com)
Intrahepatic tumors1
  • Perihilar tumors are the most common CCCs, and intrahepatic tumors are the least common. (medscape.com)
Lymphocytes2
  • Chemo-radio therapeutic outcomes are poor in CCA patients because the tumor is highly desmoplastic with fibrogenic connective tissue and immune cells such as T lymphocytes, natural killer (NK) cells and macrophages that infiltrate the tumor epithelium [ 4 ]. (aging-us.com)
  • 4 According to the number of tumor-infiltrating lymphocytes, tumors can be divided into three phenotypes: immune-inflamed, immune-excluded, and immune-desert types. (nature.com)
Metastatic cholangiocarcinoma3
  • Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study. (esmo.org)
  • This triplet was evaluated in the open-label multicenter phase Ib/II S4-13-001 study of 88 patients with previously untreated locally advanced unresectable or metastatic cholangiocarcinoma. (ascopost.com)
  • 1. Borad MJ, Bai L-Y, Chen M-H, et al: Silmitasertib (CX-4945) in combination with gemcitabine and cisplatin as first-line treatment for patients with locally advanced or metastatic cholangiocarcinoma: A phase Ib/II study. (ascopost.com)
Macrophages2
  • These studies suggest that there is a bi-directional crosstalk between macrophages and CSCs that promotes stemness renewal and tumor associated macrophage polarization. (springer.com)
  • Moreover, depletion of macrophages or inhibition of WNT signaling with one of two small molecule WNT inhibitors in mouse and rat CC models markedly reduced CC proliferation and increased apoptosis, resulting in tumor regression. (jci.org)
Extrahepatic cholangiocarcinomas1
  • Comprehensive molecular profiling of intra- and extrahepatic cholangiocarcinomas: potential targets for intervention. (cdc.gov)
Metastasis2
  • In animal studies, CXCL5 promoted tumor growth and metastasis without altering in vitro proliferative and invasive ability of ICC cells, and this effect was mediated by the recruitment of intratumoral infiltrative neutrophils by tumor-derived CXCL5. (nih.gov)
  • We sought to analyze the therapeutic value of LND relative to tumor location and preoperative lymph node metastasis (LNM) risk. (univr.it)
Removal of the tumor2
  • However, patients that are candidates for resectability are few and moreover many of these patients will have a relapse despite apparent removal of the tumor. (wikipedia.org)
  • If a benign tumor is painful or interferes with hearing, surgical removal of the tumor may be necessary. (health32.com)
Patients19
  • 05), when compared with patients with tumors showing no necrosis. (qxmd.com)
  • In this study, we used bioinformatics tools to analyze transcriptome data from cholangiocarcinoma (CCA) patients in multiple datasets (Sun Yat-sen University, TCGA and GSE32225 cohorts) to identify mechanisms that regulate tumor infiltration by immune cells and survival outcomes. (aging-us.com)
  • The survival outcomes of CCA patients were associated with the TP53 gene mutation status, levels of Oncostatin M (OSM) expression, and the proportions of tumor-infiltrating immune cell types, including dendritic cells, monocytes, and T follicular helper cells. (aging-us.com)
  • Background: The therapeutic role of lymphadenectomy (LND) for intrahepatic cholangiocarcinoma (ICC) patients remains ill-defined. (univr.it)
  • Primary sclerosing cholangitis, an idiopathic inflammatory condition of the biliary tree, has been associated with the development of cholangiocarcinoma in up to 40% of patients. (wikipedia.org)
  • We hypothesized that CTCs are associated with poor survival of patients with cholangiocarcinoma (CCA). (johnshopkins.edu)
  • PDT is effective in restoring biliary drainage and improving quality of life in patients with nonresectable disseminated cholangiocarcinomas. (medscape.com)
  • In patients with medially inoperable or unresectable tumors, primary radiotherapy, with or without chemotherapy, has provided a survival advantage and significant palliation over stent placement or bypass surgery alone. (medscape.com)
  • A study of 66 patients with unresectable intrahepatic cholangiocarcinoma treated with hypofractionated radiation therapy reported 2-year outcomes of 84% local control and 58% overall survival. (medscape.com)
  • In a study of 1636 patients with unresectable localized intrahepatic cholangiocarcinoma, the addition of radiation to chemotherapy was associated with an improvement in overall survival. (medscape.com)
  • In tumor samples from patients with ICC, increased TAN and TAM levels were correlated with elevated p-STAT3 expression. (bmj.com)
  • Positive findings will support further evaluation in clinical trials using the combination of CX-4945 with gemcitabine and cisplatin and may provide a new therapeutic option for patients with cholangiocarcinoma. (mayo.edu)
  • Although I knew the therapy was experimental and none of the previous eight patients who had received tumor-infiltrating lymphocyte therapy had experienced a benefit from it, I figured I had nothing to lose and enrolled in the study. (ascopost.com)
  • Silmitasertib, a novel inhibitor of casein kinase 2 (CK2), was combined with gemcitabine and cisplatin (the standard of care) in patients with previously untreated advanced cholangiocarcinoma. (ascopost.com)
  • Furthermore, recent locoregional therapies for tumor control including trans-luminal photodynamic therapy and radiofrequency ablation also benefit these patients. (omicsonline.org)
  • Cholangiocarcinoma in patients with primary sclerosing cholangitis: a multicenter case-control study. (medscape.com)
  • AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: By the AFC-IHCC-2009 study group. (cancercentrum.se)
  • The value of F-18 FDG PET in patients with primary sclerosing cholangitis and cholangiocarcinoma using visual and semiquantitative analysis. (cancercentrum.se)
  • Toward personalized medicine for intrahepatic cholangiocarcinoma: Pharmacogenomic stratification of patients. (cdc.gov)
Survival6
  • 05). Multivariate survival analysis confirmed tumor necrosis (p = .038) as the only independent prognostic variable. (qxmd.com)
  • Liu Q , Lan T , Song Y , Cai J , Yu X , Chen W , . Oncostatin M expression and TP53 mutation status regulate tumor-infiltration of immune cells and survival outcomes in cholangiocarcinoma. (aging-us.com)
  • Our study demonstrates that OSM expression and TP53 mutation status regulate the tumor infiltration by immune cells and survival outcomes in CCA. (aging-us.com)
  • Associations between CTC, patient and tumor characteristics, and survival were examined using the Cox's proportional hazards model. (johnshopkins.edu)
  • PDT as a treatment for cholangiocarcinoma has been shown to increase survival. (nursingcenter.com)
  • Implications of CA19-9 elevation for survival, staging, and treatment sequencing in intrahepatic cholangiocarcinoma: A national cohort analysis. (medscape.com)
Outcomes2
  • Cholangiocarcinoma (CCA) is an aggressive tumor occurring in bile ducts and associated with dismal outcomes. (lww.com)
  • These coexpression factors (SASH3 and CD53) can be used to classify tumor purity phenotypes and to predict clinical outcomes. (hindawi.com)
Malignant tumor2
  • Cholangiocarcinoma (CCA) is a highly malignant tumor originating from the intra- or extra-hepatic bile ducts that has shown increasing morbidity and mortality rates worldwide in the last few years [ 1 ]. (aging-us.com)
  • By the time I received the diagnosis, the malignant tumor covered nearly all of the right side of my liver. (ascopost.com)
Symptoms1
Biopsy2
  • The cholangioscope is used to see and biopsy the tumor directly. (hopkinsmedicine.org)
  • Hybridization (ISH) assay (in participants with IHC 2+ tumors) at a central laboratory on new biopsy tissue or archival tissue from the most recent biopsy. (who.int)
Unresectable1
  • Stents usually are used if the tumor is unresectable or if the patient is not a surgical candidate. (medscape.com)
Malignancies1
  • Cholangiocarcinomas (CCCs) are malignancies of the biliary duct system that may originate in the liver and extrahepatic bile ducts, which terminate at the ampulla of Vater. (medscape.com)
Lesions1
  • Imaging Tests of the Liver and Gallbladder Imaging is essential for accurately diagnosing biliary tract disorders and is important for detecting focal liver lesions (eg, abscess, tumor). (msdmanuals.com)
Lung5
  • We find that lung squamous cell carcinoma tumors from AAs exhibit higher genomic instability-the proportion of non-diploid genome-aggressive molecular features such as chromothripsis and higher homologous recombination deficiency (HRD). (nature.com)
  • I first underwent surgery to remove several tumors from my right lung. (ascopost.com)
  • Lung carcinoma tumor mutation burden was calculated by analyzing TCGA single nucleotide polymorphism data. (hindawi.com)
  • Based on the tumor purity and lung carcinoma gene matrix, we performed weighted gene coexpression network analysis (WGCNA), and the tumor purity-related module was identified. (hindawi.com)
  • Figure 32.1 Histological appearance of a carcinoid tumor of the lung. (osmosis.org)
Solid Tumor1
  • On 30 November 2017, a collaborative action between the US Food and Drug Administration (FDA) and the Centers for Medicare and Medicaid Services (CMS) announced that a 324-gene panel offered by Foundation Medicine, F1CDx, would be FDA approved and receive national coverage through CMS for any solid tumor type [ 1 ] with enrollment in an observational registry. (medscape.com)
Therapeutic1
Hepatic1
  • Cholangiocarcinoma is a high-mortality primary hepatic malignancy. (omicsonline.org)
Surgical1
  • Cholangiocarcinoma (CC) is typically diagnosed at an advanced stage and is refractory to surgical intervention and chemotherapy. (jci.org)
Therapy3
  • Adjuvant and preoperative radiation therapy has been used to reduce tumors in an effort to make them resectable. (medscape.com)
  • Diagnosed with stage IV cholangiocarcinoma, I enrolled in a study investigating tumor-infiltrating lymphocyte therapy. (ascopost.com)
  • Cost-Effectiveness Analysis of a New Second-Line Treatment Regimen for Advanced Intrahepatic Cholangiocarcinoma: Biomarker-Driven Targeted Therapy of Pemigatinib Versus 5-FU Chemotherapy. (cdc.gov)
Epithelium2
  • Cholangiocarcinomas arise from the intrahepatic or extrahepatic biliary epithelium. (medscape.com)
  • This tumor originates in the biliary epithelium. (msdmanuals.com)
Adenocarcinomas1
  • More than 90% are adenocarcinomas, and the remainder are squamous cell tumors . (medscape.com)
Stomach1
  • low mitotic rate TYPES ▪ Embryonic origin of GI tract (e.g. foregut, midgut, hindgut) Foregut tumors (e.g. stomach) ▪ Type I ▫ Most common ▫ Originates from enterochromaffin-like (ECL) cells ▫ In association with high gastrin levels secondary to chronic atrophic gastritis ▫ Small, usually benign ▪ Type II ▫ Originates from ECL cells ▫ In association with high gastrin levels induced by gastrinomas (e.g. (osmosis.org)
Malignancy1
  • EUS-guided fine-needle aspiration has a greater sensitivity for detecting malignancy than ERCP with brush cytology but has the potential for tumor seeding. (medscape.com)
Extracellular1
  • In addition to tumor cells, there are also other components such as stromal cells, inflammatory cells, vasculature, and the extracellular matrix [ 1 ]. (hindawi.com)
Anatomical location2
  • Based on the anatomical location of tumor along the biliary tree, CCA can be further characterized into either intrahepatic or extrahepatic CCA (iCCA/eCCA) [ 1 ]. (springer.com)
  • It can be classified according to anatomical location as intrahepatic cholangiocarcinoma (ICC) or extrahepatic cholangiocarcinoma (ECC). (lww.com)