Tumor cells tumor receptors laminin. Medical search. Frequent questions

Cell motility measurements by computer-assisted time-lapse videomicroscopy of the alpha 7-transfected cells revealed an 8-10-fold increase in motility on laminin-1 and its E8 fragment, but not on fibronectin. (uea.ac.uk)
Previous studies have implicated β1 integrins in cancer since they regulate cell adhesion and migration/invasion on tumor stroma proteins such as fibronectin laminin and collagen (33). (biotech-angels.com)
It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. (mytaq.com)
For example, tumor cell motility mediated by α3β1 integrin on its ligand, laminin-332 (laminin-5), can be 3-4 fold faster than motility mediated by other β1 integrins, such as the collagen receptor, α2β1, or the fibronectin receptor, α5β1. (uiowa.edu)
Whereas endothelial cells plated on fibronectin or fibrinogen activate NF-κB in response to flow, cells on collagen or laminin do not. (rupress.org)
Furthermore, altering the extracellular matrix to promote p38 activation in cells on fibronectin suppresses NF-κB activation, suggesting a novel therapeutic strategy for treating atherosclerosis. (rupress.org)
Shr NEAT domains, however, do not contribute significantly to the binding of methaemoglobin but mediate binding to the ECM components fibronectin and laminin. (tcdb.org)
These chondrocyte/ECM interactions are regulated by a large family of transmembrane glycoproteins whereby beta 1 integrins are the most widely expressed and interact with several matrix proteins such as collagen, fibronectin, vitronectin and laminin [ 4 ]. (biomedcentral.com)

Emerging techniques using the analysis of circulating tumor cells show promising results in predicting and identifying the early stages of breast cancer metastasis in patients. (iiarjournals.org)
The majority of deaths from breast cancer are not due to the primary tumor itself, but are the result of metastasis to other organs in the body ( 2 ). (iiarjournals.org)
Currently, detection of breast cancer metastasis relies on clinical manifestations of the spread to distant organs, biopsies of affected organs, radiological evaluations, imaging methods and serum tumor markers ( 3 , 4 ). (iiarjournals.org)
An emerging method to detect metastasis is the analysis of circulating tumor cells (CTCs), which has shown promise in filling the gaps left by other diagnostic methods. (iiarjournals.org)
Multiple brain metastasis in a patient with known non-small cell lung adenocarcinoma. (medscape.com)
Dr. Welm completed her PhD in Cell and Molecular Biology at Baylor College of Medicine in Houston, TX under the supervision of Gretchen Darlington, PhD. She then went on to conduct postdoctoral training in Dr. J. Michael Bishop's laboratory at the University of California, San Francisco where her work focused on developing new models of breast cancer metastasis. (utah.edu)
Dr. Welm's group discovered that the Ron kinase pathway is an important facilitator of breast cancer metastasis through its unique dual function in tumor cells and in resident macrophages. (utah.edu)
The process of metastasis involves the spread of neoplastic cells to locoregional or distant body sites via lymphatic vessels and/or bloodstream. (hindawi.com)
The process of metastasis is the consequence of migration of melanoma cells from the primary lesion, to locoregional and distant body sites via the lymphatic circulation and the bloodstream. (hindawi.com)
Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. (biotech-angels.com)
These findings demonstrate crosstalk between a tyrosine kinase receptor and an integrin involved in carcinoma cell invasion and metastasis and may explain in part how inhibitors of EGFR impact malignant disease. (biotech-angels.com)
sequence present in chick lung DNA ingredients normalized to chick GAPDH using real-time qPCR as referred to previously (28) with adjustments: probe-AGACCAGCCTGGGCAACATAGTGAAA 5 GAPDH probe-AGATGCTCTGCGGGAAAGCAGTGAAT 5 A typical curve was produced through quantitative amplification of genomic DNA extracted from chick lung homogenates formulated with a serial dilution of FG cells and comparative adjustments in metastasis had been reported. (biotech-angels.com)
Fig. 1 (A) EGF induces avβ5-mediated Rap1 activation and cell metastasis Fig. 5 The first 9 YXXP tyrosine residues in the CAS substrate domain name are required for αvβ5-mediated migration and metastasis Statistics Unless stated otherwise bar graphs represent mean±SD of triplicate samples. (biotech-angels.com)
Since αvβ5 requires activation to promote cell migration we considered whether EGF and integrin αvβ5 could coordinately influence the spontaneous metastasis of FG HIF-C2 cells in vivo. (biotech-angels.com)
While EGF stimulation had no effect on primary tumor growth it increased pulmonary metastasis 3-fold HIF-C2 which was abolished by shRNA-mediated knockdown of integrin β5 (Fig. 1C). (biotech-angels.com)
Importantly knockdown of β5 did not influence β1 integrin expression (Supplemental Fig. S1C) or primary tumor growth (Fig. 1C) indicating that EGF and αvβ5 coordinately and specifically regulate the spontaneous metastasis of FG cells in this model. (biotech-angels.com)
Src activation downstream of EGFR is required for αvβ5-mediated carcinoma cell invasion and metastasis EGF receptor ligation and Src activation have been linked to the growth and malignant properties of many tumors (2 4 To assess whether HIF-C2 EGF-mediated migration was Src-dependent FG cells had been treated using a Src kinase inhibitor (SKI-606) ahead of EGF excitement. (biotech-angels.com)
EGFR is a key mediator of oncogenesis in NSCLCs, with its activation inducing tumor proliferation and growth, angiogenesis, invasion and metastasis, and inhibiting apoptosis ( 10 ). (spandidos-publications.com)
Integrins mediate cell adhesion and migration during development, in homeostasis, and in a variety of pathological settings, including tumor cell metastasis. (uiowa.edu)
PAR1 Action in Tumor Development and Metastasis. (tufts.edu)
We have demonstrated that PAR1 blockade induces apoptosis and chemosensization in the primary tumor, and inhibits metastasis to the lungs. (tufts.edu)
Tadalafil is a known phosphodiesterase-5 Distinct metastasis and resistance development by self- (PDE-5) inhibitor, which have anti-cancer effects in vari- renewing nascent cancer cells in response with the ous types of cancer [2]. (sagepub.com)
Among the proteolytic enzyme systems mixed up in degradation of extracellular matrix during tumor development invasion and metastasis may be the urokinase-type plasminogen activator (uPA) program. (tam-receptor.com)
10 11 The hypothesis of a causal part of uPA-catalyzed plasminogen activation and plasmin proteolytic activity in main tumor growth local invasion and/or metastasis was recently strongly supported by studies with tumors growing on mice with targeted disruption of the uPA or plasminogen genes 3 including a study having a genetically induced mammary carcinoma. (tam-receptor.com)
RAF265 A high level of PAI-1 expression by human or murine cancer cells growing on nude mice was reported to be associated with impairment of tumor growth invasion and/or metastasis. (tam-receptor.com)
23 In work with PAI-1 gene-deficient mice transplanted murine transformed keratinocytes needed host PAI-1 for tumor invasion and vascularization 24 25 whereas a genetically induced mammary carcinoma was unaffected by PAI-1 gene deficiency with respect to tumor growth vascularization and metastasis. (tam-receptor.com)
The laminin tyrosine-isoleucine-glycine-serine-arginine (YIGSR) peptide, corresponding to the 929-933 sequence of the Î²1 chain, is known to be a functional motif with effects on the inhibition of tumor metastasis, the regulation of sensory axonal response and the inhibition of angiogenesis through high affinity to the 67 kDa laminin receptor. (peptide.com)
These results show that a specific adhesion receptor (VLA-2) can markedly enhance both experimental and spontaneous metastasis. (tmu.edu.tw)
In contrast to the metastasis results, there was no difference in either the in vitro growth rate or apparent in vivo tumorigenicity of RD and RDA2 cells. (tmu.edu.tw)
It is noteworthy that our study showed for the first time the anti-tumor effect of an endothelial cell vaccine against B16/F10 melanoma in both of the subcutaneous tumor and the lung metastasis models. (kinasepathway.com)

These proteins are often measurable in the blood of individuals with cancer and may be used to both diagnose and follow treatment of the tumors. (wikipedia.org)
A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. (lookformedical.com)
This review emphasizes key studies that support the targeted delivery of Sindbis vectors to tumor cells, highlighting their effectiveness in expressing tumor-associated antigens and immunomodulating proteins. (bvsalud.org)
Previously we have shown that the locomotion of murine skeletal myoblasts is specifically and significantly enhanced on laminin but not on other matrix proteins. (uea.ac.uk)
The cell surface receptors that interpret these cues engage cytoplasmic partners to transduce signals, but recent work reveals that many receptors also interact laterally with cell surface proteins that can be critical for proper receptor function. (uiowa.edu)
To begin to build such an interaction map, we have initially focused on integrins, the major receptors for extracellular matrix proteins. (uiowa.edu)
Our earlier studies helped to establish that α3β1 integrin is distinguished from other β1 integrins, such as α2β1 and α5β1, by its ability to avidly engage in complexes with members of the tetraspanin family of cell surface adaptor proteins. (uiowa.edu)
Tetraspanins, so named because of their four transmembrane domains, are a large family of proteins known for their ability to assemble multi-protein cell surface complexes. (uiowa.edu)
Integrin α3β1 strongly interacts with one particular tetraspanin, CD151, which in turn links α3β1 into larger cell surface complexes that may contain other tetraspanins, Ig superfamily (IgSF) proteins, growth factor receptors, membrane-bound growth factors, and novel proteins (Figure 1). (uiowa.edu)
Transcriptional profiling by genechip analysis revealed that PAR1 expression promotes the expression of mesenchymal proteins such as vimentin, laminin, and integrin, and down-regulates epithelial proteins such as E-cadherin, claudin, zona occludens and cytokeratin. (tufts.edu)
The proteins of such MAPKs increased and were then repress UniProt differential download Sarkozy, Israël et whereby steps include to the spliced group before any further cell. (erik-mill.de)
In addition, proteomic profile confirmed that a set of proteins, related to tumor aggressiveness, were positively affected by targeted nanoparticles. (dovepress.com)
Laminin proteins are integral components of structural scaffolding in animal tissues. (sigmaaldrich.com)
All mobile functions, which range from regular cell maintenance and homeostasis, specific functions particular to mobile types, or generating responses because of exterior stimulus, are mediated by proteins inside the cell. (bioskinrevive.com)
There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)
His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)

Otiz-Urda and colleagues (7) showed the development of human being epidermal squamous cell carcinomas required the interaction between the two extracellular matrix molecules laminin 332 (LM332) and type VII collagen and recent studies show that this interaction is definitely mediated by signaling through integrin mediated adhesions. (monossabios.com)
SKI-606 suppressed EGF-induced Src phosphorylation in FG cells (Supplemental Fig. S2A) and obstructed EGF-mediated migration on vitronectin however HIF-C2 had no influence on EGF-independent migration on collagen (Fig. 2A). (biotech-angels.com)
Laminin peptide YIGSR induces collagen synthesis in Hs27 human dermal fibroblasts. (peptide.com)
According to subsequent experiments, we found that the YIGSR peptide strongly enhanced collagen type 1 synthesis without changing cell proliferation or cellular MMP-1 level. (peptide.com)
The VLA-2-positive RDA2 cells not only showed increased adhesion to collagen and laminin in vitro, but also formed substantially more metastatic tumor colonies in nude mice after either intravenous or subcutaneous injection. (tmu.edu.tw)
They associate with type IV collagen via entactin and perlecan and bind to cell membranes through integrin receptors, dystroglycan glycoprotein complexes and Lutheran blood group glycoproteins. (sigmaaldrich.com)
Laminin has active domains for collagen binding, cell adhesion, heparin binding, and neurite outgrowth fragment. (sigmaaldrich.com)

One of the major laminin receptors of myoblasts is the alpha 7 beta 1 integrin, which was first described in human MeWo melanoma cells and Rugli glioblastoma cells. (uea.ac.uk)
In order to investigate and directly test the role of the alpha 7 integrin in cell migration on laminin, we expressed the murine alpha 7B splice variant in human 293 kidney cells and 530 melanoma cells which cannot migrate on laminin and are devoid of endogenous alpha 7. (uea.ac.uk)
These findings prove that alpha 7 integrin expression confers a gain of function-motile phenotype to immobile cells and may be responsible for transduction of the laminin-induced cell motility. (uea.ac.uk)
Sdc-1 associates with the 3 chain of LM332 via 31 integrin (8) and with the short arm of the laminin 2 chain via 64 integrin (9). (monossabios.com)
The latent website of AG-1478 enzyme inhibitor TGF1 has an v integrin binding site and studies have suggested that v integrins sequester latent TGF1 to the cell surface and control its activation locally (11). (monossabios.com)
Another form of integrin functional diversity is the ability of individual integrins to mediate different responses in different cell types. (uiowa.edu)
For example, integrin α3β1 is implicated in promoting the growth and invasion of some tumor cell types, but in acting as a suppressor in the progression of other tumor types. (uiowa.edu)
By mechanisms that we are still unraveling, α3β1 integrin appears to generate signaling that helps to promote stable cell-cell junctions among tumor cells, and this junction-stabilizing function may oppose α3β1's pro-migratory functions. (uiowa.edu)
Cloned integrin α 2 subunit complementary DNA was expressed on human rhabdomyosarcoma (RD) cells to give a functional VLA-2 (α 2 β 1 ) adhesion receptor. (tmu.edu.tw)

Patients are mostly young and late diagnosis, which means thicker tumors (thicker than 1 mm, or Breslow index ≥1 mm: the Breslow index is the measurement in mm of the vertical thickness of the primary tumor) and/or involvement of regional lymph nodes, causes a greater risk of developing a disseminated disease. (hindawi.com)
in vivo yet does not influence primary tumor growth or activation of other integrins on these cells. (biotech-angels.com)

MNU 47 mg/kg, i.v). Tadalafil was ad- apoptosis and also simultaneously affect cancer cell ministered from 7th to 110th day at the dose specified growth and adhesion, mitochondrial energy homeostasis, above. (sagepub.com)
Mesenchymal stem cells secrete factors that inhibit apoptosis in H9c2 cardiac myoblasts. (anl.gov)
We treated TMZ-resistant cells U251-TMZ and T98G-TMZ to normoxia or hypoxia and silenced NUPR1 in hypoxia-treated U251-TMZ and T98G-TMZ cells to assess cell viability, proliferation, apoptosis, LC3-II/LC3-I and p62 expressions, and autophagic flux under different concentrations of TMZ. (techscience.com)
Animal experiments demonstrated that fingolimod could reduce edema, cell apoptosis and cerebra atrophy and show neuroprotective function in ICH rats [ 8 ]. (karger.com)
Likewise, dexamethasone can reduce cerebral cell apoptosis and inhibit inflammation [ 10 ,] and deferoxamine (DFX) provides new therapy target [ 11 ]. (karger.com)
Propidium iodide staining and flow cytometry analysis of Annexin V binding was utilized to measure the progression of the cell cycle and the induction of apoptosis. (techscience.com)
Abstract Fos-related antigen 1 (Fra-1) is a nuclear transcription factor that regulates cell growth, differentiation, and apoptosis. (techscience.com)
It is involved in the proliferation, invasion, apoptosis and epithelial mesenchymal transformation of malignant tumor cells. (techscience.com)
Fra-1 is highly expressed in gastric cancer (GC), affects the cycle distribution and apoptosis of GC cells, and participates in GC occurrence and development. (techscience.com)
The serine protease Granzyme B (GzB) is primarily expressed by cytotoxic T lymphocytes and natural killer cells, and functions in allowing these cells to induce apoptosis in virally-infected or transformed cells. (biomedcentral.com)
For example, GzB expression in urothelial carcinoma was implicated in promoting tumour cell invasion, whereas its expression in nasal-type NK/T lymphomas was found to correlate with increased apoptosis. (biomedcentral.com)
Given the fact that ALK+ ALCL exhibits high levels of apoptosis and is typically responsive to conventional chemotherapy, we examined whether GzB expression might play a role in sensitizing ALK+ ALCL tumour cells to apoptosis. (biomedcentral.com)
ALK+ ALCL cell lines stably expressing GzB or non-targeting (control) shRNA were generated and apoptosis was examined by anti-PARP western blotting and terminal deoxynucleotidyl transferase dUTP nick end labelling. (biomedcentral.com)
While spontaneous apoptosis was similar in ALK+ ALCL cell lines expressing either GzB or control shRNA, GzB shRNA-expressing cells were less sensitive to staurosporine or doxorubicin-induced apoptosis as evidenced by reduced PARP cleavage and decreased DNA fragmentation. (biomedcentral.com)
Our findings are the first to demonstrate that GzB expression sensitizes ALK+ ALCL cell lines to drug-induced apoptosis. (biomedcentral.com)
Kinase signaling is certainly a robust and central mobile system that mediates indication transduction events and it is involved in an array of nearly all mobile processes including, however, not limited by, the control of cell routine progression, transcriptional legislation, cell change, proliferation, differentiation, and IKK-alpha apoptosis. (bioskinrevive.com)

These data show that sdc-1 is definitely important both early in the development of pores and skin tumors and in progression of pores AG-1478 enzyme inhibitor and skin cancers suggesting that reduced manifestation of sdc-1 could be a useful marker for progression in neoplastic skin lesions. (monossabios.com)
Expanded manifestation of 64 within papillomas undergoing premalignant progression arising from 2-stage chemical carcinogenesis is associated with variations AG-1478 enzyme inhibitor in the connection of cells with laminin in their matrix (5,6). (monossabios.com)
Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment. (mytaq.com)
He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)

Imaging modalities that enable the in vivo localization of Sindbis vectors within lymph nodes and tumors are discussed. (bvsalud.org)
Fc-ARMs efficiently interacted with antibodies in vivo and amassed in tumors. (kashbiotech.com)
To test therapeutic efficacy of the 198 AuNPs-EGCg in vivo the researchers established a unilateral flank model of prostate cancer derived from human PC-3 cells in SCID mice. (genengnews.com)
Developing in vivo assays of metastatic colonization using bioluminescence imaging to monitor tumor growth in real time in live animals (see Figure 3). (uiowa.edu)
Laminin receptors are overexpressed in a large number of human tumors and the high in vivo affinity of EGCG toward Laminin receptors has allowed to develop Laminin receptor specific radioactive gold nanoparticles to achieve tumor specificity (14). (sbbn.org.br)
and (c) full in vivo investigations on therapeutic properties of EGCG-198-AuNP agent in treating prostate tumors and (d) the overall implications of Green Nanotechnology of therapeutic beta emitting nanoparticles in oncology. (sbbn.org.br)
Finally, the treatment efficacy of DOX-SiNPs-TZ (1:8 Hc-TZ) was evaluated in vivo by PET and supported by MS-based proteomics profiling of tumors. (dovepress.com)
SiNPs-TZ (1:8 Hc-TZ) tumor uptake was significantly greater than that of SiNPs-TZ (1:2 Hc-TZ) at 6 hours post-injection (p.i.) in ex vivo biodistribution experiment. (dovepress.com)

Other oncofetal antigens are trophoblast glycoprotein precursor and immature laminin receptor protein (also known as oncofetal antigen protein). (wikipedia.org)
Entrez protein entry for trophoblast glycoprotein precursor 37 kiloDalton oncofetal antigen protein and immature laminin receptor protein are identical, universal T-cell inducing immunogens on primary rodent and human cancers. (wikipedia.org)
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. (lookformedical.com)
P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)
Northern blotting of the transfected cells showed that the alpha 7 mRNA was expressed efficiently, and the protein was detected on the cell surface by immunofluorescence and fluorescence-activated cell sorter analysis. (uea.ac.uk)
Laminin 5 (Ln5) is an extracellular matrix protein that plays an important role in cell migration and tumor invasion. (spandidos-publications.com)
Abstract: Protease-activated receptor 1 (PAR1) is a G protein-coupled receptor that is not expressed in normal breast epithelia, but is up-regulated in invasive breast carcinomas. (tufts.edu)
RAF265 uPA catalyzes the transformation from the inactive zymogen plasminogen towards the energetic broad-spectrum protease plasmin which can degrade many extracellular protein eg fibrin and laminin. (tam-receptor.com)
5 6 uPA-directed activation of plasminogen takes place mainly over the cell surface area after concomitant binding of uPA to its particular receptor uPAR and of plasminogen to protein with C-terminal lysines. (tam-receptor.com)
1 The hypothesis has been supported by quantification of uPA protein in components of main tumors including breast carcinomas demonstrating that high levels of uPA are correlated with a poor prognosis. (tam-receptor.com)
18-20 Injections of PAI-1 protein into immunodeficient mice bearing transplanted human tumors led to either inhibition of tumor growth 21 or stimulation of tumor growth at low PAI-1 level injected and inhibition of tumor growth at high PAI-1 level injected. (tam-receptor.com)
Endometrial ( EN ) and placental ( PL ) morphology and protein synthesis during pregnancy ( PG ) and pseudopregnancy ( PS ) in the cat. (anl.gov)
Marrow-derived mesenchymal stem cells ( MSC ) express cardiac specific protein in co-culture. (anl.gov)
preferentially, post-translational amino-acid JmjC increases are activated provided and conserved to regulate pentose cell polysaccharides with antimicrobial program protein and Clot positions. (erik-mill.de)
The hemolytic Group A Streptococcus (GAS) possesses the Shr protein which as noted above, participates in iron acquisition by obtaining heme from host hemoglobin and delivering it to the adjacent receptor on the surface, Shp. (tcdb.org)
Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. (nature.com)
Evidence suggests that the protein plays a role in tumor invasion. (bvsalud.org)

Laminin is an extracellular matrix multidomain trimeric glycoprotein and is the main non-collagenous component of basal lamina that supports adhesion, proliferation and differentiation. (sigmaaldrich.com)

This laminin product was isolated from mouse Engelbreth-Holm-Swarm tumor. (sigmaaldrich.com)

The signaling inhibitory antibody quickly induces ligand-independent receptor clustering and internalization via each caveolin and clathrin-mediated pathways. (kashbiotech.com)
As well as, DLL4 ligand binding to the NOTCH3 receptor mediates transendocytosis of NOTCH3-ADCs into ligand-expressing cells. (kashbiotech.com)
NOTCH3-ADCs internalize into receptor and ligand cells impartial of signaling and induce cell dying in each cell sorts representing an atypical mechanism of ADC cytotoxicity. (kashbiotech.com)
Given the multi-domain architecture of Ln5, it seems conceivable that other receptors in addition to integrins interact with one of its many potential ligand sites to mediate its diverse cellular functions, including activation of EGFR signaling. (spandidos-publications.com)
There are several subtypes of melanocortin receptors, each having a distinct ligand specificity profile and tissue localization. (lookformedical.com)
The ESCRT portion tends typically human for receptor-ligand transport that is fulfilment metabolized unidirectional binds. (erik-mill.de)
Biochemical evaluation revealed solid serine 897 phosphorylation PA-824 (pS897-EphA2) indication (Fig. 1C) demonstrating which the previously characterized ligand-independent Akt-EphA2 signaling axis is normally energetic in these cells (19). (bio2009.org)
There is small basal tyrosine-phosphorylation within the juxtamembrane domains of Eph receptors (p-EphA/B) indicating an over-all insufficient ligand-induced activation of Eph receptors including EphA2 that was in keeping with the undetectable appearance of cognate ligands such as for example ephrin-A1 (Fig. 1C). (bio2009.org)
Arousal with exogenous ligand ephrin-A1 resulted in activation of EphA2 and inactivation of Akt concomitant with dephosphorylation of Akt substrate site S897 (Fig. 1C D). In keeping with our previously report in lots of various other cell types (36) ERK1/2 actions had been also markedly decreased upon ligand arousal in GSCs. (bio2009.org)
As a result EphA2 receptor is normally portrayed in glioma stem cells where it mediates ligand-dependent signaling as evidenced by PA-824 Akt and ERK inhibition in addition to ligand-independent signaling indicated by PA-824 S897 phosphorylation. (bio2009.org)
EphA2 appearance and ligand-induced tumor suppressive. (bio2009.org)

For several decades, neovascularization is believed to be accomplished by proliferation of mature endothelial cells residing in the local vessels through the process of angiogenesis [ 6 ]. (hindawi.com)
PAI-1 was also observed in some myoepithelial cells encircling periodic foci of ductal carcinoma (9 of 25) some endothelial cells (8 of 25) some cancers cells (3 of 25) plus some mast cells (6 of 25). (tam-receptor.com)
and syngeneic endothelial cells [23]. (kinasepathway.com)
However, preparation of a considerable amount of tumor vascular endothelial cells from an individual patient is almost impossible. (kinasepathway.com)
In addition, cell lines are expected to share characteristics with tumor vascular endothelial cells [25]. (kinasepathway.com)
Transcytosis through microvascular endothelial cells is another possible mechanism of meningeal invasion during meningitis. (medscape.com)

MTT assay was performed to determine the proliferation of cancer cells. (techscience.com)
In addition, overexpression of ZYX in hepatoma cell lines (PLC/PRF/5, HCCLM3) enhanced their proliferation, migration and invasion, whereas ZYX knockdown had the opposite effects (SK HEP-1, Huh-7). (techscience.com)
Estrogens are female sex hormones that have genotoxic and proliferation-enhancing effects in cells. (helsinki.fi)

Syndecan-1 (sdc-1) is a cell surface proteoglycan that mediates the connection of cells with their matrix, influencing attachment, migration and response to growth factors. (monossabios.com)
In contrast, sdc-1 null fibroblasts display increased rates of cell migration. (monossabios.com)
Knockdown of Rap1b expression in FG cells selectively blocked EGF-induced migration on vitronectin (Fig. 1B) supporting a role for Rap1 in the β5/EGF-mediated cell migratory response. (biotech-angels.com)
To verify a job for endogenous Src in EGF-induced migration FG cells had been transduced expressing C-terminal Src kinase (CSK) an inactivator of Src family members kinases (34). (biotech-angels.com)
Needlessly to say appearance of CSK (however not kinase-dead CSK) suppressed EGF-induced Src activation (Fig. 2B) and cell migration on. (biotech-angels.com)
Cues in the extracellular microenvironment govern the behavior of migrating cells by triggering changes in migration speed or direction. (uiowa.edu)
Thus, a more sophisticated understanding of cell migration will require a "cell surface interaction map" describing the physical and functional connections between receptors and their cell surface partners. (uiowa.edu)
Currently, a major focus in the lab is determining (i) the extent to which assembly into tetraspanin complexes can help to explain α3β1 integrin's ability to mediate unusually rapid tumor cell migration, and (ii) the implications of tetraspanin association for the role of α3β1 in metastatic tumor cell spread. (uiowa.edu)
We have observed that ectopic expression of PAR1 in MCF-7 breast carcinoma cells induces a fibroblast-like morphological change and a corresponding enhancement of migration and invasion. (tufts.edu)
During migration in embryos, cells must alter their overall adhesiveness to the substrate to allow locomotion. (silverchair.com)

PMID- 17684491 OWN - NLM STAT- MEDLINE DCOM- 20080304 LR - 20220309 IS - 1476-5594 (Electronic) IS - 0950-9232 (Linking) VI - 27 IP - 7 DP - 2008 Feb 7 TI - Microglia-derived TGF-beta as an important regulator of glioblastoma invasion--an inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II receptor. (dbcls.jp)
PG - 918-30 AB - The invasion of tumor cells into brain tissue is a pathologic hallmark of malignant gliomas and contributes to treatment failures. (dbcls.jp)
Transforming growth factor-beta (TGF-beta) can enhance tumor growth, invasion, angiogenesis and immunosuppression. (dbcls.jp)
Antagonizing TGF-beta activity has been shown to inhibit tumor invasion in vitro and tumorigenicity, but a systemic inhibition or lack of TGF-beta signaling results in acute inflammation and disruption of immune system homeostasis. (dbcls.jp)
Microglia strongly enhanced glioma invasiveness in the co-culture system, but this invasion-promoting activity was lost in glioma cells stably expressing shTbetaRII, indicating a crucial role of microglia-derived TGF-beta in tumor-host interactions. (dbcls.jp)
triple knockout mice and noticed significantly elevated invasion of GSCs in human brain pieces from knockout mice weighed against those in the outrageous type or heterozygous littermates which gives experimental proof for the longer suspected function of ephrins in tumor microenvironment in regulating tumor cells dissemination. (bio2009.org)
Outcomes Akt-EphA2 signaling axis is normally turned on in glioma stem cells (GSC) To research the function of EphA2 in glioma cell invasion (33;34). (bio2009.org)
These cells recapitulate the gene appearance patterns and biology of individual GBM including diffuse infiltrative invasion of human brain parenchyma upon intracranial implantation (33) and for that reason constitute an excellent model to research the function of EphA2 in GBM invasion. (bio2009.org)
Here, we reported that mammalian target of rapamycin complex 2 (mTORC2) kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion. (techscience.com)

Therapeutic potentials of mesenchymal stem cells (MSCs) depend largely on their ability to secrete cytokines or factors that modulate immune response, enhance cell survival, and induce neovascularization in the target tissues. (hindawi.com)
To find better therapies, patient-specific models that mimic the biology of tumour tissues and interactions between different cell types are developed. (ipfdd.de)
Scientists report on the development of a radioactive gold nanoparticle for prostate cancer therapy that they claim is far less toxic to normal tissues than traditional radiation therapy and results in massive reduction in tumor volume and increased survival in experimental mice after just one dose. (genengnews.com)
This retention was facilitated by the high affinity of the EGCg for laminin67R, and also by the size of the nanoparticles, which prevented them from escaping the tumor and entering surrounding tissues. (genengnews.com)
Taken together, these features of RAGE allow the receptor to propagate cellular dysfunction in a number of pathophysiologically relevant situations, most often dictated by the formation and persistence of ligands in the tissues. (jci.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Expression levels of miR-145-5p and miR-145-3p were markedly reduced in cancer tissues, and ectopic expression of these miRNAs inhibited cancer cell aggressiveness, suggesting that both miR-145-3p as well as miR-145-5p acted as antitumor miRNAs. (oncotarget.com)
The largest cell panels available today are derived from cancerous tissues, since a crucial step towards personalized cancer medicine is the identification of transcriptional signatures that can guide drug prescription. (biomedcentral.com)
This capability to globally measure the state of the cell or tissues has since extended and advanced into numerous various other techniques which have been modified to allow even more high-throughput analyses. (bioskinrevive.com)

Redirecting endogenous antibodies in the bloodstream to tumor cells utilizing artificial molecules is a promising strategy to set off anti-tumor immune responses. (kashbiotech.com)
Capsaicin is a phytochemical extracted from chili peppers and exerts many pharmacological actions, such as anti-tumor and anti-inflammatory effects. (techscience.com)
These advantages may have contributed to anti-tumor effects on melanoma with high malignancy. (kinasepathway.com)

and (4) refining "precision medicine" for metastatic breast cancer using functional assays in patient-derived breast tumor grafts. (utah.edu)

When rasHa transduced cells of both genotypes were grafted onto nude mice, null tumors converted to SCC with higher rate of recurrence confirming the skin painting experiments. (monossabios.com)

Reported in PNAS , the team's work with the β-emitting gold nanoparticles ( 198 AuNPs-EGCg) demonstrated that following injection into a prostate tumor the vast majority of the particles were retained within the tumor itself, and rapidly internalized by the tumor cells. (genengnews.com)
Kattesh V. Katti, M.D., Ravi Shukla, M.D., and colleagues detail their studies in a paper titled "Laminin receptor specific therapeutic gold nanoparticles ( 198 AuNP-EGCg) show efficacy in treating prostate cancer. (genengnews.com)
One particularly attractive feature of radioactive gold nanoparticles is that it does not have to be incorporated into every tumor cell to have a therapeutic effect. (sbbn.org.br)
In our continued efforts to apply Green Nanotechnology for the development of therapeutic radioactive gold nanoparticles, recently we have discovered that the high antioxidant capacity of Epigallocatechin gallate (EGCG), which is the most abundant catechin polyphenol in tea, can be used to convert radioactive Gold-198 precursor to the corresponding biocompatible radioactive gold nanoparticles functionalized with Laminin receptor specific EGCG. (sbbn.org.br)

Previous studies demonstrated that MSCs could ameliorate the pathology associated with ischemic heart disease, ischemic stroke, and peripheral vascular disease by releasing several critical factors that increase cell survival, provide an appropriate microenvironment for repairing damaged tissue, and induce neovascularization [ 3 - 5 ]. (hindawi.com)
Together, these observations suggest that PAR1 and EGFR cooperatively induce Epithelial-to-Mesenchymal Transition (EMT) in breast carcinoma cells. (tufts.edu)
For example, the therapeutic efficacy data for GA-198AuNP corroborate their ability to induce tumor staticity because tumors harvested from the treatment group consisted largely of necrotic tissue, indicating extensive tumor cell kill. (sbbn.org.br)
In addition, autologous cell vaccine may have less possibility to induce pathologic autoimmunity due to the tolerance mechanism. (kinasepathway.com)

Pathologic changes seen on autopsy lack major cell and tissue injury but include signs of pleural effusion, pulmonary edema, ascites, and gastrointestinal mucosa bleeding ( 5 , 6 ), all indications of systemic vascular leakage. (cdc.gov)
We studied the secretome profile of gestational tissue-derived MSCs and their effects on functions of endothelial progenitor cells (EPCs), another angiogenic cell type that plays an important role during the neovascularization. (hindawi.com)
Notably, the β radiation emitted by the 198 AuNPs-EGCg particles has a range of about 11 mm, which is far reaching enough to zap prostate tumor cells directly surrounding the administration site, but not far reaching enough to subject more distant healthy tissue to radiation, they state. (genengnews.com)
A total of 98 tissue samples were obtained from the tumor bank of Guangdong Lung Cancer Institute (Guangzhou, China) between 2004 and 2006. (spandidos-publications.com)
It is this feature that has attracted recent attention to apply nanotechnology for the effective delivery of therapeutic doses of beta emitting nanoparticles selectively to tumor tissue and tumor cells. (sbbn.org.br)
The recently published EORTC 62012 trial which involved 455 patients with locally advanced, unresectable or metastatic high-grade soft tissue sarcomas concluded that an intensified therapy with doxorubicin and ifosfamide is not suitable for palliation of advanced soft tissue sarcomas because of the severe side-effects and should only be used when the specific goal is tumour shrinkage ( 13 ). (spandidos-publications.com)
Intended therapeutic targets, though important, are detected in only a fraction of signatures, and cell line tissue of origin has been identified as a confounding factor throughout the signature detection procedure. (biomedcentral.com)
The ECM of each tissue dictates how normal remains normal and how aberration in its components or the loss of laminins will eventually lead to genomic instability and cancer. (philinbiomed.org)
Because regular human brain tissue express small EphA2 the actual fact that it's expressed in every seven GSC lines examined and NSCs signifies a potential function of EphA2 in stem cell legislation which is examined below. (bio2009.org)
Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. (sigmaaldrich.com)
TissueFab ® - Low endotoxin GelMA-UV Laminin kit enables the precise fabrication of 3D cell models and tissue constructs for research in 3D cell biology, tissue engineering, in vitro tissue models, and regenerative medicine. (sigmaaldrich.com)
Fluorescent staining of actin filaments in fixed tissue sections and tissue culture cells preparations.Note: Unlike many actin antibodies, Acti-stain™ 555 phalloidin binds only to F-actin resulting in low background fluorescence. (cytoskeleton.com)
Phalloidin has been labeled with a proprietary red fluorescent dye which allows it to be used to stain actin filaments in tissue cultured cells and tissue sections (1, see Figure 1) and cell-free preparations. (cytoskeleton.com)

Mesenchymal stem cells (MSCs) are multipotent stem/progenitor cells which can differentiate to several mesodermal derivatives and possess an ability to secrete factors involved in neovascularization and immunomodulation [ 1 , 2 ]. (hindawi.com)
Aavs are known to target mesenchymal stem cells (MSCs) in the synovium, and we herein tested the hypothesis that the infection of MSCs may promote the expression of immunoregulators to skew the anti-viral cellular immune responses. (bvsalud.org)
Intravenous administration of mesenchymal stem cells ( MSC ) following myocardial infarction prevents contractile dysfunction. (anl.gov)
Intravenously injected mesenchymal stem cells integrate with the heart after coronary artery occlusion. (anl.gov)
Bone marrow mesenchymal stem cells secrete factors that exert anti-apoptotic and pro-apoptotic effects on H9c2 cardiac myoblasts. (anl.gov)
The bioink kit can be used with most extrusion-based bioprinters, are biodegradable, and are compatible with human mesenchymal stem cells (hMSCs) and other diverse cell types. (sigmaaldrich.com)

Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR), including gefitinib and erlotinib, have become the standard first-line therapy for patients with advanced non-small cell lung cancers (NSCLCs) harboring activating EGFR mutations ( 4 , 5 ). (spandidos-publications.com)
Immunocytochemical ( ICC ) Localization of Transforming Growth Factor- ( TGF- ), Epidermal Growth Factor ( EGF ), and Epidermal Growth Factor Receptor ( EGFR ) in the Cat Endometrium and Placenta. (anl.gov)
The overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is usually associated with aggressive and infiltrating breast cancer (BC) phenotype, and metastases. (dovepress.com)

In the case of melanoma, circulating cells may find a suitable microenvironment in the first draining lymph node, known as the sentinel lymph node, in other lymphnodes or in distant organs, leading to secondary tumor growth (Figure 1 ). (hindawi.com)
For decades, researcher Mina Bissell pursued a revolutionary idea - that a cancer cell doesn't automatically become a tumor, but rather, depends on surrounding cells (its microenvironment) for cues on how to develop. (philinbiomed.org)

Aberrant NOTCH3 signaling and overexpression is oncogenic, related with most cancers stem cells and drug resistance, but therapeutic concentrating on stays elusive. (kashbiotech.com)
In contrast, there is a lack of effective therapeutic options to treat patients with lung squamous cell carcinoma (lung SCC) [ 3 ]. (oncotarget.com)
When considering therapeutic application to human, autologous cells may be preferable to avoid host reactions to allogeneic or xenogeneic components in the vaccine. (kinasepathway.com)

Most the cells portrayed the stem marker nestin whereas just a part of cells had been positive for GFAP a differentiation marker. (bio2009.org)

Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs. (utah.edu)
14 In addition the value of PAI-1 like a predictor of poor prognosis in breast cancer is self-employed of tumor size and of estrogen receptor status 15 and the prognostic value of combined measurement of uPA and PAI-1 levels in tumor extracts is independent of the prognostic value of HER2 status. (tam-receptor.com)
Analysis of assay conditions for the measurement of total uterine nuclear estrogen receptor at low temperature. (anl.gov)
Raloxifene, a selective estrogen receptor modulator, is also known to be a lysosomotropic agent. (techscience.com)
Estrone is only a weak agonist of estrogen receptor but it serves as a precursor for biosynthesis of 17β-estradiol, 16α-hydroxyestrone and catechol estrogens. (helsinki.fi)
While 16α-hydroxyestrone has relatively weak affinity for estrogen receptor, it has prolonged effect due to covalent binding to the receptor. (helsinki.fi)

In the course of the subcutaneous tumor growth, occasional tumor MK-4827 cost necrosis in the Tpit/E vaccinated mice was observed, suggesting occurrence of vascular damage, though further studies are required. (kinasepathway.com)
Once bacteria enter and replicate in the CSF, inflammation of the subarachnoid space ensues because of bacterial (eg, cell wall components) and host factors (eg, prostaglandins, tumor necrosis factor alpha). (medscape.com)

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and is divided into three subtypes according to pathogenesis: adenocarcinoma, squamous cell carcinoma and large cell carcinoma [ 2 ]. (oncotarget.com)

We present that Fc-ARM concentrating on folate receptor-α (FR-α) redirects a clinically used antibody combination to FR-α + most cancers cells, leading to most cancers cell lysis by pure killer cells in vitro . (kashbiotech.com)
Hybridomas were produced PD0332991 in vitro from spleen cells of a Tpit/E-vaccinated mouse. (kinasepathway.com)

CTCs are tumor cells originating from primary sites or metastases that circulate in the patients' bloodstream and are very rarely found in healthy individuals ( 9 , 10 ) ( Figure 1 ). (iiarjournals.org)
Brain metastases are cancer cells that have spread to the brain from primary tumors in other organs in the body (see the image below). (medscape.com)

Therapy of xenografts with NOTCH3-ADCs results in sustained tumor regressions, outperforms standard-of-care chemotherapy , and permits concentrating on of tumors that overexpress NOTCH3 impartial of signaling inhibition. (kashbiotech.com)

The nanoparticles, derived from the Au-198 isotope, incorporate an extract from green tea known as epigallocatechin-gallate (EGCg), which effectively latches the nanoparticles onto the prostate tumor cells and facilitates their internalization. (genengnews.com)
The tumor-targeting EGCg actually has a dual function, the University of Missouri, Columbia-led team reports. (genengnews.com)
Analysis of the treated tumors showed that over 70% of the injected dose of 198 AuNP-EGCg was retained at the tumor site, and the nanoparticles were taken up in high concentrations by the tumor cells. (genengnews.com)
This novel intratumorally injectable 198 AuNP-EGCg nanotherapeutic agent may provide significant advances in oncology for use as an effective treatment for prostate and other solid tumors. (genengnews.com)

Oral squamous cell carcinoma (OSCC) is a common malignant tumor. (techscience.com)

TGF1 is known for its ability to function as a pro-oncogenic element late in malignancy development and also function to inhibit tumor formation early in malignancy development (12C15). (monossabios.com)

Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion. (utah.edu)

In addition, most systemic treatments (eg, the use of chemotherapeutic agents, which may penetrate the brain poorly) can transiently weaken the blood-brain barrier (BBB) and allow systemic disease to be seeded in the CNS, leaving the brain a safe haven for tumor growth. (medscape.com)
This vertical growth phase represents a key event for the cell spread, since it allows the cells to migrate deeply in the dermis, in the lymphatics, and the bloodstream. (hindawi.com)
Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. (mytaq.com)
Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). (mytaq.com)
Capsaicin (10-100 µM) significantly inhibited testosterone-treated WPMY-1 cell growth at 48 h by MTT assay. (techscience.com)
This study evaluates the effect of A. montana leaves hexane extract on several signaling cascades and gene expression in metastatic breast cancer cells upon insulin-like growth factor-1 (IGF-1) stimulation. (techscience.com)

Other unusual features of the receptor include its ability to engage classes of molecules, rather than individual ligands, and its enhanced surface expression in environments rich in RAGE ligands. (jci.org)
Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)

This process requires the tumor cells to penetrate the basement membrane and cross the subendothelial membrane. (medscape.com)
It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. (bvsalud.org)

Immunofluorescent staining demonstrated that monolayer 827 cells portrayed moderate to high degrees of endogenous EphA2 (Fig. 1B). (bio2009.org)

The results showed that treatment resulted in tumor shrinkage within just one week, and by three weeks the average tumor volume in the treated animals was 80% less than the tumor volume in control animals. (genengnews.com)

Secondly, the green tea extract directly and selectively binds with laminin67R receptors that are overexpressed in prostate tumor cells. (genengnews.com)

The path length of the emitted radiation is sufficient to allow effective therapy following uptake into a subpopulation of tumor cells. (sbbn.org.br)
Glu-4, a relatively inactive IL-1 beta analogue in most cells, stimulated glucose uptake in a time and dose dependent manner with kinetics indistinguishable from those of IL-1 beta. (eurekamag.com)

However, analogous advanced treatments are not available for patients with lung squamous cell carcinoma (lung SCC). (oncotarget.com)

The tumor-suppressor gene PTEN negatively regulates the PI3K/Akt signaling pathway ( 13 ). (spandidos-publications.com)
Accumulation of M1 at the several cell of the homocysteine DNA is utilised to enable the housekeeping for the miR-200B of poisoning PI3K. (erik-mill.de)

It is well known that miR-145-5p (the guide strand) functions as a tumor suppressor in several types of cancer. (oncotarget.com)
decade, Tadalafil used to inhibit the myeloid derived Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, (A Central University), Vidya Vihar, Raebareli road, Lucknow, UP suppressor cells (MDSCs) and restore the T cells in can- 226 025, India cer patients as compared to the normal peoples [4]. (sagepub.com)

Cancers of both lymphoid and non-lymphoid origin also express GzB, and in some cases this expression has been linked to pathogenesis or sensitizing tumour cells to cell death. (biomedcentral.com)

GzB expression is also a hallmark of the non-Hodgkin lymphoma, anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL). (biomedcentral.com)

Description: This mAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. (mytaq.com)

One of two major pharmacologically defined classes of adrenergic receptors. (lookformedical.com)
The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS. (lookformedical.com)

The autoimmune attack occurs when autoantibodies form against the nicotinic acetylcholine postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)
Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)

Stereotactic radiosurgery is a more preferred treatment modality for radio-resistant lesions such as nonsmall cell lung cancer, renal cell carcinoma, and melanoma. (medscape.com)
The expression of biomarkers can be detected intracellularly or on the cell membrane of melanoma cells or noncancer cells in association with the melanoma. (hindawi.com)

Provided that the panel of cell lines is large enough, this approach allows for a new type of gene expression analysis where basal expression levels are correlated to drug response phenotypes. (biomedcentral.com)
2018). Deletion of in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons. (tcdb.org)
Se localiza en la membrana basal de la lámina lúcida y funciona uniendo las células epiteliales a las membranas basales. (bvsalud.org)

FAU - Wesolowska, A AU - Wesolowska A AD - Laboratory of Transcription Regulation, Department of Cell Biology, Nencki Institute of Experimental Biology, Warsaw, Poland. (dbcls.jp)
He has taught anatomy, physiology, and cell biology at Trinity Christian College for 34 years, and he still teaches there in addition to his work at Argonne. (anl.gov)

This study explored the expression of Ln5 and the role of its relationships with PTEN, phospho-EGFR (p-EGFR) and phospho-Akt (p-Akt) in the prognosis of patients with non-small cell lung cancer (NSCLC). (spandidos-publications.com)
PAR1 expression also induced a concerted shift in the expression of ErbB family of receptors and ligands, promoting the constitutive activity of EGFR/HER2 signaling. (tufts.edu)
This proposed mechanism is supported by empirical evidence from the NCI-60 panel of breast carcinoma cells, which demonstrate 100% correlation of PAR1 expression with EGFR expression and EMT status. (tufts.edu)

Binding of these ligands to RAGE does not accelerate clearance or degradation but rather begins a sustained period of cellular activation mediated by receptor-dependent signaling. (jci.org)
This last point is crucial, since it explains how upregulation of this receptor can contribute to an ascending spiral of RAGE-dependent cellular perturbation. (jci.org)
As described below, these diverse situations range from the complications of diabetes and cellular perturbation in amyloidoses to immune and inflammatory responses and tumor cell behavior. (jci.org)
They gated mediated to facilitate a JmjC cellular debris, specifically secreted in direct receptors( Clissold & Ponting 2001). (erik-mill.de)
Of note, DAPK can activate PKD in HeLa cells under oxidative stress conditions 11 , thus suggesting that PKD activation may contribute to cellular death. (nature.com)

Description: Quantitative sandwich ELISA for measuring Human Zika Virus IgG (ZV-IgG) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (mytaq.com)
Description: Quantitative sandwich ELISA for measuring Pig Transfusion transimitted virus/Hepatitis H virus antibody (IgG) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (mytaq.com)
17 Despite the prognostic value of PAI-1 the precise tumor biological functions of PAI-1 are not known. (tam-receptor.com)

Anatomy18

Organisms10

Diseases104

Chemicals and Drugs43

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes41

Disciplines and Occupations1

Information Science5

Health Care8

Fibronectin8

Metastasis30

Proteins18

Collagen7

Integrin9

Primary tumor2

Apoptosis16

Progression4

Vivo8

Protein18

Glycoprotein1

Engelbreth-Holm-Swarm1

Ligand11

Endothelial cells6

Proliferation3

Migration10

Invasion9

Tissues9

Anti-tumor3

Breast tumor1

Nude mice1

Gold nanoparticles4

Induce4

Tissue13

Mesenchymal6

Epidermal growth f3

Microenvironment2

Therapeutic3

Differentiation1

Estrogen receptor6

Necrosis2

According to pathogenesis1

Vitro2

Metastases2

Inhibition1

EGCg4

Malignant1

Inhibit tumor1

Affinity1

Growth6

Molecules2

Basement membrane2

Endogenous1

Shrinkage1

Binds1

Uptake2

Squamous cell carc1

PI3K2

Suppressor2

Cancers1

Kinase1

Proteoglycan1

Adrenergic2

Postsynaptic2

Melanoma2

Basal3

Biology2

EGFR3

Cellular5

Biological3