Tumor cells phase of the cell cycle. Medical search. Frequent questions

These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
Angiogenesis is essential in the process of carcinogenesis to facilitate tumor progression and metastasis. (spandidos-publications.com)
Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
Aggressive tumors typically demonstrate a high glycolytic rate, which results in resistance to radiation therapy and cancer progression via several molecular and physiologic mechanisms. (springer.com)
Some authors will say that the restriction point and the G1/S checkpoint are one and the same, but more recent studies have argued that there are two different points in the G1 phase that check the progression of the cell. (wikipedia.org)
The G1/S checkpoint is the point between G1 phase and the S phase in which the cell is cleared for progression into the S phase. (wikipedia.org)
Slows tumor progression in mouse xenograft models. (tocris.com)
Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. (frontiersin.org)
In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression. (frontiersin.org)
Neutrophils also contribute to tumor progression, yet establishing the difference between PMN-MDSCs and tumor-associated neutrophils (TAN) remains challenging ( 11 , 15 , 16 ). (frontiersin.org)
It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
T he presence and activity of various proteins are required in the cell cycle progression. (ukessays.com)
The results demonstrated that JIB extract combined with cisplatin enhanced the inhibition of cell growth, proliferation, and survival through the obstruction of cell cycle progression and AKT/mTOR and MAPK signaling as well as the induction of cell apoptosis. (medsci.org)
This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca2+ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the incidence of interruption in antitumoral treatment. (researchgate.net)
In contrast, an anti-inflammatory response mediated by CD4+/Th2 and M2 TAMs will favor tumor progression. (bvsalud.org)
I. To estimate the progression free survival in pediatric patients treated with palbociclib with advanced solid tumors (including CNS tumors), non-Hodgkin lymphomas or histiocytic disorders that harbor activating genetic alterations in alterations in cell cycle genes. (clinicaltrialsgps.com)
By blocking cell cycle progression, p27 prevents cells from dividing too quickly or at the wrong time. (medlineplus.gov)
For example, when p27 is held (sequestered) in the fluid that surrounds the nucleus (the cytoplasm) instead of being transported into the nucleus, the protein is unavailable to block cell cycle progression. (medlineplus.gov)
The expression of p53 is directly linked to a blockage of cell cycle progression at G0/G1 phase and upregulates Bax, cytochrome studies have shown the ability of the bioactive compounds of flavokawain B and alpinetin to target UCK2 enzyme specifically, inducing cell cycle arrest and subsequently leading to cancer cell death, possibly through interfering the MDM2-p53 signalling pathway. (nanoker-society.org)
May be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T cells. (lu.se)
May be involved in tumor progression. (lu.se)

Our results indicated that AST inhibits cell proliferation through phase-specific cell cycle arrest and caspase-dependent apoptosis. (spandidos-publications.com)
If the DNA damage is too severe for repair, p53 can also initiate apoptosis (programmed cell death). (reasons.org)
We summarized that four main organic sulfides in garlic, diallyl disulfide (DADS), diallyl trisulfide (DATS), S‑allylmercaptocysteine (SAMC) and allicin, may contribute to the regulation of tumor cell apoptosis, migration and the cell cycle. (spandidos-publications.com)
The active ingredients in garlic oil correspond mainly to a family of organosulfur molecules, which selectively increase redox stress in cancer cells, leading to apoptosis and death ( 23 ). (spandidos-publications.com)
This compound at dosages of Avosentan (SPP301) 50C200 M kills tumours by up\regulating intracellular reactive oxygen varieties 4, arresting cell cycle, inducing apoptosis 5, 6, reversing drug resistance 7 and inhibiting angiogenesis 8, 9. (findadig.com)
Wogonin induces Erk phosphorylation 13 and activates p38MAPK 14 to result in apoptosis of tumour cells. (findadig.com)
Furthermore, T44Bf selectively induces apoptosis in leukemia cell lines when compared to normal peripheral blood mononuclear cells. (tmu.edu.tw)
Our simulations show that, if HMGB1 is overexpressed, then the oncoproteins CyclinD/E, which regulate cell proliferation, are overexpressed, while tumor suppressor proteins that regulate cell apoptosis (programmed cell death), such as p53, are repressed. (biomedcentral.com)
The HMGB1 signal transduction can influence the cell's fate by two important processes - apoptosis and cell proliferation - which are regulated respectively by the proteins p53 and CyclinE, acting in two different signaling pathways. (biomedcentral.com)
The protein p53 is one of the most important tumor suppressor proteins: its activation can lead to cell cycle arrest, DNA repair, or apoptosis. (biomedcentral.com)
Which signaling pathways are fundamental for describing HMGB1 signal transduction, and what mechanisms are responsible to explain recent results linking overexpression of HMGB1 with decrease of apoptosis (and increased cancer cell survival)? (biomedcentral.com)
Apoptosis was measured by Hoechst 33258/propidium iodide double staining of nuclear chromatin and the formation of gaps into the lymphendothelial barrier in a three-dimensional co-culture model consisting of MCF-7 tumour cell spheroids and human lymphendothelial monolayers. (nature.com)
In HL-60 leukaemia cells, di-GA activated caspase 3 and dose-dependently induced apoptosis. (nature.com)
These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)
Inhibition of these kinases may result in cell cycle arrest and apoptosis of tumor cells that express these kinases. (ncats.io)
Additionally, JIB extract induced B16/F10 cell apoptosis via the caspase cascade. (medsci.org)
DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis. (shengsci.com)
In cancer, ROS plays a dual role with anti-tumorigenic and pro-tumorigenic effects in cell signaling pathways that control proliferation, survival, apoptosis, and inflammation. (bvsalud.org)
In this study, we investigated the role of autophagy and apoptosis in Newcastle disease virus (NDV)-infected chicken cells and tissues. (immune-source.com)
In bottom line, we confirmed that autophagy brought about by genotype VII NDV infections was important for virus-like replication, NDV-induced apoptosis, and cell survival in buy 480-11-5 chicken cells and tissues. (immune-source.com)
Apoptosis of tumor cells increased significantly as concentration of cocultured TD-MSCs increased. (immune-source.com)
Cell proliferation was detected by MTT assay and apoptosis was measured by FACS in ESCC cells after WISP2 downregulation and overexpression. (biomedcentral.com)
WISP2 overexpression inhibited cell growth and induced cell apoptosis, suppressed cell migration and invasion in ESCC cells. (biomedcentral.com)

Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
Among its different constituents, Astragalus polysaccharides have been most widely studied particularly for their immunopotentiating properties, such as stimulation of murine B cell proliferation and cytokine production ( 6 ). (spandidos-publications.com)
Hypoxia and genetic defects that chronically drive proliferation leave such tumors dependent on a steady supply of nutrients, especially glucose. (springer.com)
Previous researches completed by our team have also demonstrated that resveratrol inhibits the proliferation, invasion, and metastasis of colorectal cancer cells [ 5 ]. (hindawi.com)
Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has proven to be a modulator of multiple intercellular signalling pathways linked to inflammation, to proliferation, growth, invasion, drug sensitivity, angiogenesis and metastasis of cancer cells. (researchgate.net)
Many potential anticancer mechanisms of these compounds were proposed, including the inhibition of cell proliferation, changes in enzyme activity and immune regulation ( 21 , 22 ). (spandidos-publications.com)
Blocks cell proliferation, causing arrest in G 1 phase of the cell cycle. (tocris.com)
Moreover, a number of extracellular proteins can bind to their receptors and activate signaling pathways that promote the proliferation of cancer cells. (biomedcentral.com)
CyclinE is a cell cycle regulatory protein which regulates the G1-S phase transition during cell proliferation. (biomedcentral.com)
To the best of the authors' knowledge, no computational model has been proposed to investigate the importance of HMGB1 in tumor proliferation. (biomedcentral.com)
MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)
In addition, AKT/mTOR signaling and MAPK signaling were inhibited by JIB extract to suppress melanoma cell growth and proliferation. (medsci.org)
Emerging evidence has demonstrated that WISP2 is critically involved in cell proliferation, migration, invasion and metastasis in cancers. (biomedcentral.com)
Therefore, we aim to explore the effects and the potential mechanism of WISP2 on proliferation and motility and invasion of ESCC cells. (biomedcentral.com)
One study further identified that WISP2 expression was enhanced by serum and correlated with serum-induced cell proliferation in breast cancer cells, demonstrating that WISP2 could enhance cell proliferation in breast cancer [ 8 ]. (biomedcentral.com)
It also showed strong, selective cytotoxic activity and inhibited the proliferation of human cervical cancer (SiHa), colorectal cancer (SNU-1), human liver (HepG2), human gastric adenocarcinoma (AGS), stellate liver cells, mouse melanoma cells (B16BL6) , human hepatoma cells. (naturalherbals.net)
We found that BSW shMSLN cells had decreased cyclin E, and their proliferation rate was reverted to nearly that of untransformed cells. (cdc.gov)
Cell cycle analysis showed that the BSW shMSLN cells had an increased G2 population and a decreased S phase population, which is consistent with the decreased rate of proliferation. (cdc.gov)

TP53 inhibition allows LINE-1 + cells to grow, and genome-wide-knockout screens show that these cells require replication-coupled DNA-repair pathways, replication-stress signaling and replication-fork restart factors. (nih.gov)
1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
Due to the selective expression of UCK2 in malignancy cells, a selective inhibition of this important enzyme necessitates the discovery of its potential inhibitors for malignancy chemotherapy. (nanoker-society.org)
We could confirm the increased polyploidy upon Mps1 inhibition in neuroblastoma cell lines and PDX model, leading to mitotic catastrophe activating the caspase-dependent mitochondrial apoptotic pathway. (lu.se)

The presence of TAMs in most solid tumors is correlated with poor prognosis and overall survival of patients ( 10 ). (frontiersin.org)
In addition to TAMs, solid tumors are also infiltrated by immunosuppressive, immature myeloid progenitor cells, commonly referred to as monocytic or polymorphonuclear myeloid-derived suppressor cells (M/PMN-MDSC) ( 11 - 13 ). (frontiersin.org)
In September 2021, GeoVax expanded its immuno-oncology pipeline and added a new technology platform through the acquisition of exclusive rights to Gedeptin ® , a novel patented product for the treatment of solid tumors through a gene therapy strategy known as GDEPT (Gene-Directed Enzyme Prodrug Therapy). (gabio.org)
This phase II Pediatric MATCH trial studies how well palbociclib works in treating patients with Rb positive solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with activating alterations (mutations) in cell cycle genes that have spread to other places in the body and have come back or do not respond to treatment. (clinicaltrialsgps.com)
complete response + partial response) in pediatric patients treated with palbociclib with advanced solid tumors (including central nervous system [CNS] tumors), non-Hodgkin lymphomas or histiocytic disorders that harbor activating genetic alterations in cell cycle genes. (clinicaltrialsgps.com)

The reduction in tumor volume as well as pro-apoptotic and anti-proliferative effects in HT-29 nude mice xenograft are comparable to those produced by 5-FU. (spandidos-publications.com)
We found that wogonin given at 50 and 100 mg/kg inhibited tumour growth and advertised the recruitment of DC, T, and NK cells in the tumour cells in the xenograft tumour model of mice 26. (findadig.com)
In addition, NV651 decreased tumour growth in xenograft-mouse model. (lu.se)

We find that nontransformed cells undergo a TP53-dependent growth arrest and activate interferon signaling in response to LINE-1. (nih.gov)
Wogonin also up\regulates the manifestation of p21, p27 and p53 to induce tumour cell cycle arrest in the G1/S phase 15. (findadig.com)
Present findings indicate that T44Bf-mediated antiproliferative effects are associated with a reversible chronic mitotic arrest caused by defects in chromosome alignment, followed by induced programmed cell death. (tmu.edu.tw)
JIB extract induced cell cycle arrest at the G 0 /G 1 phase and decreased cyclin and cdk protein expressions. (medsci.org)

Forkhead box protein M1 (FOXM1) is a key transcription factor (TF) that regulates a common set of genes related to the cell cycle in various cell types. (mdpi.com)
The CDKN2A/B locus contains genes encoding cell cycle inhibitors, including p16 Ink4a , which have not yet been implicated in the control of hepatic glucose homeostasis. (diabetesjournals.org)
The prognostic and treatment predictive markers currently in use for breast cancer are commonly based on the protein levels of individual genes (e.g. steroid receptors), or aspects of the tumor phenotype such as histological grade and percent of cells in the DNA synthesis phase of the cell cycle. (lu.se)
1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
have uncovered a key tumor suppressor among those genes frequently lost on chromosome 20. (elifesciences.org)
Targeted therapy drugs are used to target specific genes and proteins of cancer cells to precisely identify and attack specific types of cancer cells. (medsci.org)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)

Studies have found that E2F1 is highly expressed in a variety of tumor tissues and cells and plays a role of oncogenic gene [ 10 - 13 ]. (hindawi.com)
The tumor size and the number of proliferating cells were reduced in the tumor tissues obtained from the formononetin-treated group. (spandidos-publications.com)
But these treatments, to some extent, easily produce side effects on normal cells, organs, and other tissues of the human body, thus accelerating the death process of cancer patients. (hindawi.com)
This work aimed to compare the expression of pRb and p16INK4a as possible biomarkers in tumor tissues with and without infection by EBV or different genotypes of HPV from patients with LSCC. (bvsalud.org)
This protein is found in cells and tissues throughout the body. (medlineplus.gov)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Cyclophilin overexpression is a common event in fibrotic tissues playing a key role in different stages of the fibrotic process, including inflammation, hepatocyte death, and activation of the hepatic stellate cells leading to increased collagen production. (lu.se)

In this part of interphase, the cell synthesizes mRNA and proteins in preparation for subsequent steps leading to mitosis. (wikipedia.org)
Once the required proteins and growth are complete, the cell enters the next phase of the cell cycle, S phase. (wikipedia.org)
By holding the cell at this stage in the cell cycle, p53 gives the DNA repair proteins enough time to clean up the damaged DNA before DNA synthesis takes place. (reasons.org)
The cell cycle is strictly regulated and controlled by a complex network of signaling pathways [ 1 ], comprised of hundreds of proteins. (biomedcentral.com)
If some important proteins are mutated or there are defects in the signaling mechanisms, normal cell growth regulation will break down, possibly leading to the occurrence of cancer in the future. (biomedcentral.com)
The crosstalk is regulated by tumor suppressor proteins, including ARF, P21 and FBXW7, which are also frequently mutated in many cancers. (biomedcentral.com)
GEO-CM04S1 is the only COVID-19 vaccine that includes both SARS-CoV-2 spike and nucleocapsid proteins to advance to a Phase 2 trial in cancer patients. (geovax.com)
GeoVax's vaccine candidate (GEO-CM02) encodes the spike (S) protein as the neutralizing antibody target as well as the membrane (M) and envelope (E) proteins as T-cell targets and to support in vivo virus-like particle formation to augment potency. (geovax.com)
Regulation can occur through modification of the p27 protein's structure, its interaction with other proteins, or its localization within the cell. (medlineplus.gov)

Ovarian cancer is the most fatal malignant tumor of the female reproductive tract [ 1 ]. (hindawi.com)
For pediatric patients with refractory cytopenia, certain cytogenetic abnormalities, or malignant transformation, hematopoietic stem cell transplantation (HSCT) from a matched related or unrelated donor early in the course of the disease is the treatment of choice. (medscape.com)
In recent years, the utilization of Chinese native medicine and other plant extracts in the treatment of diseases has attracted extensive attention, especially in the area of malignant tumors. (hindawi.com)
With the changes of the diet types and the bad living habits, malignant tumors have gradually developed into a serious threat to human health and life. (hindawi.com)
Melanoma is the most malignant and lethal skin tumor owing to its high metastatic ability and the incidence of melanoma has been increasing over the years. (medsci.org)
Together, our results indicate a novel role of MSLN in the malignant transformation of bronchial epithelial cells following CNT exposure, suggesting its utility as a potential biomarker and drug target for CNT-induced malignancies. (cdc.gov)

To test whether the properties and specific values of conventional prognostic markers are encoded within tumor gene expression profiles, we have analyzed 48 well-characterized primary tumors from lymph node-negative breast cancer patients using 6728-element cDNA microarrays. (lu.se)
In vivo, BSW shMSLN cells formed smaller primary tumors and less metastases. (cdc.gov)

Genetic abnormalities associated with MDS block differentiation of hematopoietic stem and progenitor cells. (medscape.com)
Let-7 Let-7 has an essential role in cell cycle and the differentiation of cell cycle terminals. (ukessays.com)
Studies suggest that p27 is also involved in controlling cell differentiation, which is the process by which cells mature to carry out specific functions. (medlineplus.gov)
This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)

examined the mechanism of action underlying the anti-tumor effects of the complementarity-determining region (CDR) C36L1 synthetic peptide derived from the V L CDR1 of the C36 Fab fragment of the anti-vaccinia immunoglobulin. (cytoskeleton.com)
BK011P) was an essential reagent in this study, complementing the in vivo results and in vitro cell culture data which demonstrated conclusively that the C36L1 peptide targets microtubules in exerting its anti-tumor effects. (cytoskeleton.com)
Collectively, our results indicate that JIB extract showed anti-tumor effects and synergized with cisplatin against B16/F10 cells, indicating the possibility of JIB extract to be developed as adjuvant therapy for melanoma. (medsci.org)

Most patients have tumor metastasis and recurrence within 2 years, and the 5-year survival rate is 20%-40% [ 2 ]. (hindawi.com)
Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
CTC molecular characterization offers the unique potential to better understand the biology of metastasis and resistance to established therapies, and analysis of these cells presents a promising field for both advanced and early-stage patients. (shengsci.com)

The protein is linked with the pluripotency of stem cells. (wikipedia.org)
This complex inhibits mammalian target of rapamycin (mTOR) kinase, a key protein in cells that regulate the gene translation responsible for cell-cycle regulation. (medscape.com)
During G1 phase, the cell grows in size and synthesizes mRNA and protein that are required for DNA synthesis. (wikipedia.org)
In order for the cell to continue through the G1-pm, there must be a high amount of growth factors and a steady rate of protein synthesis, otherwise the cell will move into G0 phase. (wikipedia.org)
HMGB1 can activate a series of signaling components, including mitogen-activated protein kinases (MAPKs) and AKT, which play an important role in tumor growth and inflammation, through binding to different surface receptors, such as RAGE and TLR2/4. (biomedcentral.com)
Protein activation and expression were analysed by western blotting, deoxyribonucleoside triphosphate levels by HPLC, ribonucleotide reductase activity by 14 C-cytidine incorporation into nascent DNA and cell-cycle distribution by FACS. (nature.com)
In the present study we show that artificial neural networks fed with tumor gene expression data can be used to predict the ER protein values on a continuous scale. (lu.se)
1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. (ukessays.com)
2) Therefore, the proper control of protein levels is crucial for the cell cycle. (ukessays.com)
Based on this function, p27 is described as a tumor suppressor protein. (medlineplus.gov)
studies suggest that certain endocrine cells may be particularly dependent on the p27 protein to control cell division. (medlineplus.gov)
Tumour suppressor protein, p53, prevents cancer development by eliminating cells with mutagenic alterations or potential for neoplastic transformation or blocking their cell cycle permanently or by transient DNA repair [3C5]. (nanoker-society.org)
Overexpression of MDM2 leads to inactivation of p53 tumour protein, thereby diminishing its tumour suppressor function [8]. (nanoker-society.org)
Extraction of total protein Total protein was extracted from lysed HT-29 cells in an appropriate volume of ProteoJET mammalian cell lysis reagent (Fermentas, Burlington, ON, Canada). (nanoker-society.org)
This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. (cancerindex.org)
Intriguingly and in contrast to what is observed in ES cells, KDM1A depletion in cancer cells was found not to trigger any reduction in the DNMT1 or DNMT3B protein level or any change in DNA methylation. (oncotarget.com)

Circulating tumor cells as promising novel biomarkers in solid cancers. (shengsci.com)

Choline kinase (ChoK) is increased in human mammary tumors with high incidence, and this activation is associated with clinical variable indicators of greater malignancy. (aacrjournals.org)
We searched the databases such as EMBASE, PubMed, and Web of Science with the keywords "stem cell," "progenitor cell," "satellite," "senescence" and excluded the keywords "cancer," "tumor," "malignancy" and "carcinoma" until June 2020. (magiran.com)
The mouse gastric malignancy cell collection (MFC) was from Shanghai cell lender of Chinese Academy of Sciences. (findadig.com)
The modified cells are able to expand more robustly than normal cells, and this dominance induced by downregulation of the tumor suppressor increases the risk of malignancy. (elifesciences.org)
Abstract Uridine-cytidine kinase 2 is an enzyme that is overexpressed in abnormal cell growth and its implication is considered a hallmark of malignancy. (nanoker-society.org)

Approximately 80-90% of newly diagnosed lung cancers are classified as NSCLC, primarily consisting of adenocarcinoma, squamous cell carcinoma, or large cell carcinoma histologies. (frontiersin.org)
A Phase 1/2 trial is currently enrolling to evaluate the safety and efficacy of repeat cycles of Gedeptin therapy in patients with recurrent head and neck squamous cell carcinoma (HNSCC), with tumors accessible for injection and no curable treatment options. (gabio.org)
Phase 1/2 Trial - Gedeptin ® - A Phase 1/2 trial (NCT03754933) evaluating the safety and efficacy of repeat cycles of Gedeptin therapy in patients with recurrent head and neck squamous cell carcinoma (HNSCC) that have tumor(s) accessible for injection and no curable treatment options, is ongoing at Stanford University in collaboration with Emory University. (geovax.com)
Besides, 12% of patients have second- or third-degree skin reactions that are sensitive to light, and about 18% of patients develop cutaneous squamous-cell carcinoma and keratoacanthoma or occurred at the same time [ 6 ]. (medsci.org)
BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) represents one of the principal tumors of the head and neck. (bvsalud.org)
However, the function of WISP2 in esophageal squamous cell carcinoma (ESCC) is largely unclear. (biomedcentral.com)

Therefore, improving the early diagnosis rate, chemotherapy drug sensitivity, reducing tumor recurrence, and improving disease prognosis are the focus of diagnosis and treatment research at the present stage [ 8 , 9 ]. (hindawi.com)
A shortage of p27 has been associated with more aggressive tumors and a poorer prognosis. (medlineplus.gov)
MDS is rare in childhood and may have a rapidly progressive course with an extremely poor prognosis without hematopoietic stem cell transplantation (HSCT). (medscape.com)

Its expression is linked to cell cycle function and tumor growth. (wikipedia.org)
The main reason is that the regulation mechanism of the tumor cell cycle is damaged, which leads to uncontrolled cell growth. (hindawi.com)
mTOR also reduces the cell growth factors (eg, vascular endothelial growth factor) involved in new blood vessel development. (medscape.com)
Our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. (spandidos-publications.com)
The vascular endothelial growth factor (VEGF) is a well characterized angiogenic factor known to stimulate angiogenesis within a tumor ( 1 ). (spandidos-publications.com)
Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
The G1 phase, gap 1 phase, or growth 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division. (wikipedia.org)
G1 phase together with the S phase and G2 phase comprise the long growth period of the cell cycle cell division called interphase that takes place before cell division in mitosis (M phase). (wikipedia.org)
G1 phase and the other subphases of the cell cycle may be affected by limiting growth factors such as nutrient supply, temperature, and room for growth. (wikipedia.org)
Physiological temperatures are optimal for cell growth. (wikipedia.org)
The first restriction point is growth-factor dependent and determines whether the cell moves into the G0 phase, while the second checkpoint is nutritionally-dependent and determines whether the cell moves into the S phase. (wikipedia.org)
Reasons the cell would not move into the S phase include insufficient cell growth, damaged DNA, or other preparations have not been completed. (wikipedia.org)
We identified a colorectal cancer wherein a fast-growing tumor subclone downregulated LINE-1, prompting us to examine how LINE-1 expression affects cell growth. (nih.gov)
It can also exert its influence by arresting the cell cycle when the cell transitions between the G1 (cell growth) and S (DNA synthesis, readying the cell for replication) phases. (reasons.org)
Thus, the secretion of gall wasps stimulates plant cell growth and overrules homeostasis of the affected leaf area - this is similar to tumour outgrowth. (nature.com)
In turn, the plant produces GA, which seems to combat the improper growth signals and re-establishes cell-cycle control. (nature.com)
Palbociclib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. (clinicaltrialsgps.com)
Objectives Mesenchymal stem cells (MSCs) play an important role in the development and growth of tumor cells. (immune-source.com)
exhibited a growth inhibitory effect on both cell lines. (immune-source.com)
Moreover, WISP overexpression retarded tumor growth in mouse model. (biomedcentral.com)
Within cells, p27 is located primarily in the nucleus, where it plays a critical role in controlling cell growth and division. (medlineplus.gov)

NOS2 is expressed by myeloid-derived suppressor cells and M1 macrophages but not alternatively activated M2 macrophages. (thermofisher.com)
However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and neutrophils. (frontiersin.org)
Myeloid innate immune cells, such as granulocytes, monocytes, macrophages and dendritic cells (DCs), play an important role in cancer-cell recognition, initiation of inflammation and antitumor responses ( 2 ). (frontiersin.org)
In the tumor microenvironment, tumor-associated macrophages (TAMs) display an array of phenotypes beyond the M1/M2 paradigm, ranging from antitumoral to immunosuppressive, proangiogenic, immunomodulatory and tissue-remodeling phenotypes ( 7 - 9 ). (frontiersin.org)
The activation of CD8+/Th1, NK, and M1 tumor associated macrophages (TAMs), leads to tumor destruction. (bvsalud.org)

In this review, we will discuss the interplay between inflammation, ROS, and miRNAs as anticancer and tumor promoter molecules in BC. (bvsalud.org)

These are divided into two group, those miRNAs that are upregulated in cancer which are likely to be acting as oncogenes and those downregulated in cancer which are likely to be acting as tumour suppressors. (ukessays.com)
highlights the importance of gene dosage in mediating the effects of tumor suppressors. (elifesciences.org)

These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
The authors found that the peptide induces apoptotic effects on multiple cancer cells both in vitro and in vivo , inhibits tumor cell migration and invasion, and arrests cell cycle primarily in the G2M phase. (cytoskeleton.com)
Cell migration and invasion were analyzed by wound healing assay and transwell migration assay, respectively. (biomedcentral.com)
MSLN knockdown resulted in significantly decreased invasion, migration, colonies on soft agar, and tumor sphere formation. (cdc.gov)

Cell cycle analysis showed an accumulation of tumor cells predominantly in 511296-88-1 manufacture G0/G1 phase with an increase in concentration of TD-MSCs, which was confirmed by increased mRNA expression of cell cycle negative regulator p21. (immune-source.com)
Our objective was to determine if CDK2AP1 mRNA expression levels were consistent with tumour-suppressive functions in breast cancer. (cancerindex.org)

The Warburg phenotype provides tumors an enhanced resistance against cytotoxic insults. (springer.com)

Breast cancer is still one of the most important tumors among women in industrialized countries. (aacrjournals.org)
In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. (spandidos-publications.com)
In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
In addition to the aging phenomenon, stem cell senescence has been investigated in various concepts such as cancer, adverse drug effects, and as a limiting factor in cell therapy. (magiran.com)
Some studies have shown the relationship among vegetable consumption, gastrointestinal tumors and H. pylori ( 11 - 14 ), confirming that the increased consumption of fibers that are abundant in fresh fruits and vegetables is correlated with a reduced risk of gastrointestinal cancer ( 11 ). (spandidos-publications.com)
The murine colon cancer cell collection (MC\38) was kindly gifted by Dr. Hursting (University or college of Texas\Austin). (findadig.com)
The current standard of care for locally advanced non-small cell lung cancer (NSCLC) includes radiation, chemotherapy, and surgery in certain individualized cases. (frontiersin.org)
Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. (frontiersin.org)
Hence, myeloid cells play a dual role in cancer as they can initiate antitumor responses and communicate with cells of the adaptive immune system, but also promote local inflammation leading to chronic cancer-associated inflammation ( 5 , 6 ). (frontiersin.org)
Although tumor-promoting functions have been attributed to other granulocytes, like eosinophils ( 17 ), basophils ( 18 ) and mast cells ( 19 ), further research is required to fully elucidate their role in cancer, as antitumoral roles have also been described ( 20 , 21 ). (frontiersin.org)
Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
Cancer Cell Metabolism: Unique Features Inform New Therapeutic Opportunities. (nyas.org)
Milciclib is currently in phase II clinical trials for thymic carcinoma, glioma and liver cancer. (ncats.io)
Phase 2 Trials - GEO-CM04S1 - GEO-CM04S1 is being studied in a Phase 2 clinical trial (NCT04977024) as a primary vaccine for immunocompromised cancer patients who have difficulty producing antibodies and largely depend on T cells to protect against the virus responsible for COVID-19. (geovax.com)
The presence of circulating tumor cells (CTCs) in peripheral blood can serve as a "liquid biopsy" approach and has thus emerged lately as one of the hottest fields in cancer research. (shengsci.com)
DNA methyltransferases are upregulated in several tumors and aberrant DNA methylation profiles are a cancer hallmark. (oncotarget.com)
On the other hand, histone demethylases are upregulated in cancer cells. (oncotarget.com)
In cancer cells, the occurrence of this interaction has not been explored. (oncotarget.com)
Together, our findings propose a mechanistic link between KDM1A and DNA methyltransferases in cancer cells and suggest that the KDM1A/DNMT1 interaction may play a role during replication. (oncotarget.com)
MSLN overexpression was found in human lung tumors, lung cancer cell lines, and BSW cells. (cdc.gov)
Targeting the cell cycle has been proposed as a therapeutic strategy in cancer treatment with special interest in the mitotic phase. (lu.se)

Another myeloid population in the tumor microenvironment (TME) are DCs, that originate from different precursors and display various phenotypes, ranging from immunosuppressive monocyte-derived DCs (Mo-DCs) to immunocompetent cDC1 and cDC2 subsets ( 22 ). (frontiersin.org)

In addition, downregulation in expression of 18S ribosomal RNA was also observed in all treated HT-29 cells. (nanoker-society.org)

These complexes then activate S-Cdk complexes that move forward with DNA replication in the S phase. (wikipedia.org)

Mechanistically, WISP2 exerts its tumor suppressive functions via regulation of ERK1/2, Slug, and E-cadherin in ESCC cells. (biomedcentral.com)
This gene thus plays a role in both cell-cycle and epigenetic regulation. (cancerindex.org)

Focusing on the extensively studied family of thiosemicarbazone (TSC) compounds, we have previously identified 4,4′-dimethoxybenzophenone thiosemicarbazone (T44Bf) as a promising pharmacological compound in a panel of human leukemia cell lines (HL60, U937, KG1a and Jurkat). (tmu.edu.tw)

2015. A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays anti-tumor activity against melanoma in vitro and in vivo . (cytoskeleton.com)
extract (JIB extract) for melanoma cells. (medsci.org)

These findings suggest that T-cell immunity stimulated by GEO-CM04S1 may constitute a critical second line of defense to provide long-term protection against SARS-CoV-2 variants. (geovax.com)

and a high concentration of Cdk inhibitors is found during G1 phase. (wikipedia.org)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Here, we employed the used of to investigate the effectiveness of natural UCK2 inhibitors to cause HT-29 cell death. (nanoker-society.org)

Stem cell senescence in the in vitro expansion stage is an essential concern in clinical procedures of cell therapy. (magiran.com)
NV556 treatment in an in vitro 3D human liver Extracellular Matrix (ECM) cultured with a TGFβ1-activated human hepatic stellate cell line led to decreased collagen production. (lu.se)

CTCs can be isolated from blood in a non-invasive approach, and can be used to follow patients over time since these cells can provide significant information for a better understanding of tumor biology and tumor cell dissemination. (shengsci.com)

Due to the large tumor load in advanced patients, drug resistance is easy to occur during chemotherapy. (hindawi.com)

We identified the association between garlic intake and reduced risk of gastric and colorectal cancers and hypothesized that the active ingredients in garlic may act on multiple pathways to reduce the risk of gastrointestinal tumors according to published papers. (spandidos-publications.com)
Several pathways involved in cell cycle and DNA repair were affected upon NV651 treatment. (lu.se)

Therefore, screening new Chinese medicine active components and determining their antitumor effects have become a new breakthrough in the prevention and treatment of tumor disease. (hindawi.com)
Many natural products and their active components have been reported to have potential antitumor or tumor preventive properties. (hindawi.com)
Importantly, the potential tumor‑preventing effect of these garlic ingredients warrants further investigation in regards to the specific mechanism of the underlying antitumor activities. (spandidos-publications.com)
Immune cells abundantly infiltrate tumors, creating a complex environment mediated by repetitive cycles of antitumor responses and immune evasion ( 1 ). (frontiersin.org)
In GDEPT, a vector is used to selectively transduce tumor cells with a nonhuman gene, which expresses an enzyme that can convert a nontoxic prodrug into a very toxic antitumor compound. (gabio.org)

We review the possible roles for calorie restriction (CR) and very low carbohydrate ketogenic diets (KDs) in modulating the five R's of radiotherapy to improve the therapeutic window between tumor control and normal tissue complication probability. (springer.com)
In this discussion article on the basis of the developed hypothesis of induced bioregulation of tumor cells we have proposed a conceptually different methodological concept of therapeutic correction brain tumors - cytoregulatory therapy which is based on using induced regional multipotent stem cells as the main approach in the central nervous system tumors. (genescells.ru)
With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease. (lu.se)

Multiple studies have examined the issue of the optimal dose of radiotherapy in NSCLC but are complicated by the heterogeneity of the disease itself in terms of size and location of the primary tumor, number and size of involved lymph nodes, and the patient's comorbidities, all of which limit the treatment tolerability and risks. (frontiersin.org)
Delivery of tumoricidal doses to the primary tumor and involved lymph nodes is balanced by treatment-related toxicities, namely esophagitis, pneumonitis, and cardiac injury. (frontiersin.org)

A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) affects the long arm of chromosome 20 and has been predicted to harbor a tumor suppressor gene. (elifesciences.org)

Role of mesothelin in carbon nanotube -induced carcinogenic transformation of human bronchial epithelial cells. (cdc.gov)
In this study, the role of MSLN in the carcinogenic transformation of human bronchial epithelial cells chronically exposed to single-walled CNT (BSW) was investigated. (cdc.gov)

Our investigation indicates that most of these studies examined endothelial progenitor cells, hematopoietic stem cells, mesenchymal stem cells, adipose-derived stem cells, and a few others were about less-discussed types of stem cells such as cardiac stem cells, myeloblasts, and induced pluripotent stem cells. (magiran.com)
Blood cells are produced within bone marrow by specialized stem cells and progenitor cells. (elifesciences.org)

Lymphendothelial gaps, adjacent to tumour bulks, can be considered as gates facilitating metastatic spread. (nature.com)

In human somatic cells, the cell cycle lasts about 10 hours, and the G1 However, in Xenopus embryos, sea urchin embryos, and Drosophila embryos, the G1 phase is barely existent and is defined as the gap, if one exists, between the end of mitosis and the S phase. (wikipedia.org)
Somatic CDKN1B gene mutations have been identified in sporadic (nonfamilial) pituitary adenomas and in sporadic parathyroid adenomas, which are noncancerous tumors of the parathyroid glands. (medlineplus.gov)

High levels of p16INK4a are suggested as a surrogate marker of HPV or EBV infection in some head and neck tumors but in LSCC is still controversial. (bvsalud.org)

Abnormalities in this process lead to a group of diseases known as myeloid malignancies, which include acute myeloid leukaemia-in which the bone marrow produces abnormal white blood cells-and myelodysplastic syndromes, which are caused by too few mature blood cells being produced. (elifesciences.org)

PRR on myeloid cells can be triggered by pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs), but also indirectly by secondary mechanisms such as complement activation and circulating antibodies (Abs), resulting in cytolytic and phagocytic effector mechanisms. (frontiersin.org)

Pathogen clearance is mediated by mechanisms such as phagocytosis, respiratory burst with the production of ROS and RNS and release of bacteriostatic peptides, but also through the cell-extrinsic initiation of inflammation via the release of proinflammatory cytokines and chemokines ( 24 ). (frontiersin.org)

Mesothelin (MSLN) is overexpressed in many human tumors, including mesotheliomas and pancreatic and ovarian carcinomas. (cdc.gov)
The determination of testosterone in women is helpful in the diagnosis of androgenic syndrome (AGS), polycystic ovaries (Stein-Leventhal syndrome) and when an ovarian tumor, adrenal tumor, adrenal hyperplasia or ovarian insufficiency is suspected. (cdc.gov)

Aberration occurs in a stem cell that can give rise to multiple lineages. (medscape.com)
Some of p53's other important roles include stem cell maintenance and tumor suppression. (reasons.org)
Stem cell senescence causes different complications. (magiran.com)
This manuscript examines protective medicines and supplements which are capable of hindering stem cell senescence. (magiran.com)
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? (lu.se)
Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)
In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. (lu.se)
Stem cell-based therapies for Parkinson's dis- ogy company International Stem Cell Corporation ease (PD) are rapidly moving towards clinical trials. (lu.se)
A second press release [2] has indicated stem cell source, resulting in widespread excitement that the program is planning to move forward very rapidly, with all of the patients being enrolled in the Correspondence to: Roger A. Barker, John van Geest Centre first quarter of 2016 and interim results being shared for Brain Repair, Department of Clinical Neurosciences, Univer- in October 2016. (lu.se)

There were no significant associations between CDK2AP1 expression and estrogen receptor status, tumour grade and tumour type. (cancerindex.org)

During G1 phase, the G1/S cyclin activity rises significantly near the end of the G1 phase. (wikipedia.org)
However, IFN\ and IL\2 production of T cells co\stimulated by concanavalin A and wogonin offers been shown to be significantly enhanced 23. (findadig.com)

GEO-CM04S1 for Immunocompromised Patients - GEO-CM04S1 is being studied in an ongoing Phase 2 clinical trial (NCT04977024) to evaluate its safety and immunogenicity, compared to the Pfizer/BioNTech mRNA-based vaccine, in patients who have previously received either an allogeneic hematopoietic cell transplant, an autologous hematopoietic cell transplant or chimeric antigen receptor (CAR) T cell therapy. (geovax.com)
Current standard methods of curing patients with brain tumors targeted to complete elimination of tumor cells from the body are of low effectiveness. (genescells.ru)
METHODS: Tumor samples from 103 patients with LSCC were previously investigated for the presence and genotypes of HPV using the INNO-LiPA line probe assay and for the infection of EBV by qPCR. (bvsalud.org)
Several academic and industry efforts are well under owned subsidiary Cyto Therapeutics, it had received way to produce dopaminergic neurons from stem approval by the Australian government to conduct a cells under conditions compliant with use in patients. (lu.se)

Without this, the patient cells lost in PD could be replaced by grafted community is left trying to interpret complex scien- immature human dopaminergic neurons [3, 5]. (lu.se)
1998. Protection of human upper respiratory tract cell lines against sulphur mustard toxicity by hexamethylenetetramine (HMT). (cdc.gov)

The study aim was to evaluate the cytotoxic activity, using the MTT test [3-(4,5-Dimethilthiazol-2-yl)-2,5-diphenil tetrazolium bromide], from the crude extract of Picrasma crenata (Pau Tenente) and its isolated compounds, quassin and parain, in culture of rat liver tumor cells (HTC). (scielo.br)

Serum Levels of the Chemokine CXCL13, Genetic Variation in CXCL13 and Its Receptor CXCR5, and HIV-Associated Non-Hodgkin B-Cell Lymphoma Risk. (medscape.com)
To address this, concentrations of testosterone, sex hormone binding globulin, androstanediol glucuronide (a metabolite of dihydrotestosterone) and estradiol were measured in stored serum specimens from men examined in the morning sample of the first phase of NHANES III (1988-1994). (cdc.gov)
This data file contains results of the testing of 1637 males age 12 or more years who participated in the morning examination of phase 1 of NHANES III and for whom serum was still available in the repository. (cdc.gov)

Anatomy18

Organisms10

Diseases53

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Phenomena and Processes63

Disciplines and Occupations1

Information Science4

Health Care3

Progression21

Apoptosis23

Proliferation18

Inhibition4

Solid tumors5

Xenograft3

Arrest4

Genes7

Tissues7

Proteins9

Malignant6

Primary tumors2

Differentiation4

Anti-tumor effects3

Metastasis3

Protein16

Biomarkers1

Malignancy5

Squamous6

Prognosis3

Growth21

Macrophages5

Anticancer1

Suppressors2

Invasion4

MRNA expression2

Phenotype1

Cancer22

Microenvironment1

Downregulation1

Replication1

Regulation2

Pharmacological1

Melanoma2

Findings1

Inhibitors3

Vitro2

Biology1

Chemotherapy1

Pathways2

Antitumor5

Therapeutic3

Lymph2

Neoplasms1

Epithelial2

Progenitor cells2

Metastatic1

Somatic2

Head and neck1

Abnormal1

Molecular1

Inflammation1

Ovarian2

Stem cell10

Estrogen receptor1

Significantly2

Patients4

Human2

Liver1

Serum3