Tumor cells murine differentiation of cells. Medical search. Frequent questions

Other resistance mechanisms include DNA repair, suppression of oncogene activation, tumor-suppressor genes, epigenetic stabilization of chromatin structure, and apoptosis. (the-scientist.com)
Meanwhile, more-appropriately named tumor suppressor genes recognize the illegitimate activation of proliferation-driving genes and hit the brakes. (the-scientist.com)
Myeloid suppressor cells with high arginase activity are found in tumors and spleen of mice with colon and lung cancer. (aacrjournals.org)
The goal of this study was to determine whether myeloid suppressor cells producing high arginase existed in renal cell carcinoma patients. (aacrjournals.org)
Thioredoxin-1 regulates self-renewal and differentiation of murine hematopoietic stem cells through p53 tumor suppressor. (dukecancerinstitute.org)
In response to stress, cells make a critical decision to arrest or undergo apoptosis, mediated in large part by the tumor suppressor p53. (bvsalud.org)
The induction of CD11b + Gr-1 + myeloid-derived suppressor cells (MDSCs) is an important immune-evading mechanism used by tumors. (ashpublications.org)
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that expand during benign and cancer-associated inflammation. (purdue.edu)
Here, we report that expression of the mouse homolog of Drosophila tumor suppressor Lethal giant larvae 1 (Lgl1) is induced during OL differentiation. (escholarship.org)
These data establish Lgl1 as a suppressor of gliomagenesis and positive regulator of asymmetric division and differentiation in the healthy and demyelinated murine brain. (escholarship.org)
BMI-1 is thought to repress, p16(Ink4a), a cyclin-dependent kinase inhibitor and tumor suppressor that induces cell cycle arrest at the Gap 1 phase. (cancertools.org)
The INK4b-ARF-INK4a tumour suppressor locus controls the balance between progenitor cell renewal and cancer. (biomedcentral.com)
The INK4b-ARF-INK4a tumor suppressor locus (Figure 1A ) plays a central role in controlling the equilibrium between progenitor cell renewal and cancer risk [ 1 - 8 ]. (biomedcentral.com)

GVAX also upregulates the PD-1/PD-L1 pathway, and a pre-clinical model demonstrated the anti-tumor effects of combination GVAX and anti-PD-1 antibody therapy (GVAX/αPD-1). (bmj.com)
Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation. (ox.ac.uk)
Asher Bio designed AB821 to overcome the historical challenges of IL-21, including pleiotropic activation of multiple lymphoid and myeloid immune cell subsets, by focusing the IL-21 activity of AB821 to only CD8+ T cells - the immune cell type primarily responsible for anti-tumor efficacy - while avoiding activation of non-CD8 cells which may dampen overall anti-tumor efficacy and contribute to adverse effects. (pharmiweb.com)
IL-21 can have beneficial effects on anti-tumor immune responses due to its ability to activate STAT3, a master transcription factor involved in a broad spectrum of adaptive and innate immune functions. (pharmiweb.com)
In a poster titled "Selective activation of CD8+ T cells by a CD8-targeted IL-21 results in enhanced anti-tumor efficacy and safety," Renee Greer, Ph.D., Senior Scientist, Immunology at Asher Bio, shared foundational nonclinical proof-of-concept data, demonstrating that AB821 exhibits greater than 1000-fold selectivity for CD8+ T cells over other cell types. (pharmiweb.com)
They are involved in the proliferation, differentiation, and migration of tumor cells, thus becoming potentially effective molecular targets of anti-tumor drugs. (biocytogen.com.cn)

C: Tumor either Stage IA or Stage IB, but with tumor on the surface of one or both ovaries, or with capsule ruptured, or with ascites containing malignant cells or with positive peritoneal washings. (medscape.com)
or ascites present containing malignant cells or with positive peritoneal washings. (medscape.com)
A worldwide database analysis revealed that younger age, smaller tumor size, early stage, and granulosa cell tumor histologic type appear to be independent prognostic factors for improved survival in patients with malignant sex cord-stromal tumors who undergo lymph node dissection. (medscape.com)
Oral squamous cell carcinoma (OSCC) includes malignant neoplasms of the lip, oral cavity and oropharynx. (biomedcentral.com)
We found that INK4b and INK4a , but not ARF , are upregulated following the differentiation of haematopoietic progenitor cells, in ageing fibroblasts and in senescing malignant rhabdoid tumour cells. (biomedcentral.com)
Data on brain and central nervous system primary malignant and non-malignant ependymal tumours from the Central Brain Tumor Registry of the United States analytic data set and primary malignant ependymal tumours from the SEER 13 registries research data file were used to evaluate incidence and survival, respectively. (cdc.gov)
Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA. (medscape.com)

Methods: To model genetic alterations in the core signaling pathways of human glioblastoma, we induced conditional Rb knockout, Kras activation, and Pten deletion mutations in cortical murine astrocytes. (nih.gov)
Interestingly, both MO-MDSCs and PMN-MDSCs suppressed antigen-specific T-cell responses, albeit using distinct effector molecules and signaling pathways. (ashpublications.org)
Activation of mTOR-dependent pathways regulates the specification and differentiation of CD4 + T effector cell subsets. (jci.org)
To demonstrate the power of this technology, we will generate a molecular disease fingerprint allowing differentiation between three clinically indistinguishable yet biochemically distinct disease pathways underlying the deadly brain cancer glioblastoma multiforme. (nih.gov)
Using murine models of prostatitis and cancer, we identified two novel pathways, p38 and p53 signaling, that are involved in MDSC functional activity and differentiation capacity, respectively. (purdue.edu)
Where appropriate we will attempt to develop continuous murine and human NK cell lines of vrious NK phenotypes, study their regulation by IFN and IL-2, and attempt to delineate which subsets produce interferon and the pathways of differentiation as determined by cell surface markers. (grantome.com)
Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Differentiated airway epithelial cells can revert into stable and functional stem cells in vivo. (wikipedia.org)
Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk. (ox.ac.uk)
Here, we define an incoherent feed-forward loop in non-transformed human squamous epithelial cells involving p53 and the zinc-finger transcription factor KLF5 that dictates responses to differing levels of cellular stress from UV irradiation or oxidative stress. (bvsalud.org)
In normal unstressed human squamous epithelial cells, KLF5 complexes with SIN3A and HDAC2 repress TP53, allowing cells to proliferate. (bvsalud.org)
Thus, in human squamous epithelial cells, KLF5 gates the response to UV or oxidative stress to determine the p53 output of growth arrest or apoptosis. (bvsalud.org)
Here, we investigate its transformation potential using organoids from primary murine colon epithelial cells. (uni-muenchen.de)
The standard form of CD44 is usually ubiquitously expressed on epithelial cells and lymphocytes, but inclusion of one or more of 10 variant exons produces tissue-specific multiple variant isoforms (CD44v2-v10) by alternate mRNA splicing ( 9 ). (iiarjournals.org)
Innate immunity in gastrointestinal system includes epithelial cell layers that express tight cell-cell contact, secreted mucous layer which prevent entry of microbes, protective plasma protein, and circulating leukocytes, such as phagocytic macrophages, neutrophils, dendritic cells (DC), natural killer (NK) cells, NK T-cell, and innate lymphoid cells. (frontiersin.org)
Single layered intestinal epithelial cells (IECs) establish a semipermeable intestinal barrier (IB) which allows the dual role of transporting nutrients and avoiding the passage of pathogens. (frontiersin.org)
Dysregulation in intestinal epithelial monolayer cause abnormal interaction with immune cells and perturb the intestinal immune homeostasis which is associated with the clinical symptoms of IBD. (frontiersin.org)
γ-secretase inhibitors (GSIs) have been recently proposed as chemopreventive agents in gastrointestinal neoplasia, because they lead, through inhibition of the Notch signaling pathway, to goblet cell conversion in some intestinal adenomas of the Apc Min mice, and halt epithelial cell proliferation. (biologists.com)
Primary Human bronchial epithelial cells when grown in vitro have a limited lifespan and begin to deviate both in phenotype and morphology, losing the plasticity required around passage 4 or 5, for air-liquid interface (ALI) differentiation. (cancertools.org)
These Human bronchial epithelial cells expressing BMI-1 retain both viability and differentiation potential of wild-type human bronchial epithelium while importantly not demonstrating changes in cell karyotype. (cancertools.org)
Normal human bronchial epithelial cells were grown in a growth factor-supplemented medium and differentiated at ALI in bronchial epithelial differentiation medium. (cancertools.org)
Expression of polycomb protein BMI-1 maintains the plasticity of basal bronchial epithelial cells. (cancertools.org)

Phenotype switching: plasticity and/or differentiation of stromal cells and their progenitors within the tumour microenvironment regulate tumour fate. (europa.eu)
Furthermore, immunofluorescence staining of blood vessels, hypoxic areas, proliferating cells and immune cells was performed to characterize the tumor microenvironment of all three tumor models. (biomedcentral.com)
Characterization of the resulting MOC1-HPV cell lines and tumor models confirmed stable expression of HPV-16 oncogenes and differences in cell morphology, in vitro migration capacity, and tumor microenvironment characteristics. (biomedcentral.com)
Targeting Tregs to reestablish the proinflammatory and immunogenic tumor microenvironment (TME) is an increasingly attractive strategy for cancer treatment and has been emphasized in recent years. (biomedcentral.com)
In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
The cell phenotype is therefore determined by signals that target the cells received within a defined microenvironment. (unicyte.ch)

A leading contributing factor to metastasis and treatment resistance is the heterogeneity and plasticity of the cells within tumors 6 . (nature.com)
CD44, the transmembrane receptor for hyaluronan, is implicated in tumor cell invasion and metastasis. (iiarjournals.org)
Despite advances in the early detection of breast cancer and the advent of novel targeted therapies, there is still a high failure rate, mainly due to tumor invasion and metastasis ( 2 , 3 ). (iiarjournals.org)
Here, we also studied the effect of silibinin on EGFR ligand-induced CD44 expression, which is a hallmark of metastasis in various cancer cells. (iiarjournals.org)
HA-bound CD44 triggers intracellular signaling that has been linked to diverse cellular functions, such as adhesion and invasion during tumor progression and metastasis ( 10 ). (iiarjournals.org)
Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach. (medscape.com)

Recent studies have shown that aberrantly expressed gastrin-releasing peptide (GRP) and its receptor (GRP-R) critically regulate tumor cell differentiation in colon cancers developing in humans and mice. (nih.gov)
Normal function is to regulate cell division. (the-scientist.com)
Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. (nature.com)
Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis. (escholarship.org)

Tumor risk can also be influenced by mutations in genes that control the fidelity of DNA replication, the efficacy of DNA repair, and the checkpoint controls involved in DNA synthesis and chromosomal mechanics. (the-scientist.com)
Serial neurosphere culture, multi-lineage differentiation, and orthotopic transplantation were used to assess whether these mutations induced de-differentiation of cortical astrocytes into glioma stem cells. (nih.gov)
Results: G1/S-defective, Rb knockout astrocytes gained unlimited self-renewal and multi-lineage differentiation capacity, in both the presence and absence of Kras and Pten mutations. (nih.gov)
Conclusion: A defined set of core signaling pathway mutations induces de-differentiation of cortical murine astrocytes into glioma stem cells. (nih.gov)
Genotoxic colibactin-producing pks+ Escherichia coli induce DNA double-strand breaks, mutations, and promote tumor development in mouse models of colorectal cancer (CRC). (uni-muenchen.de)
Our study found that BRAF V600E mutations are moderately frequent in PA and GG and that for these tumor entities, IHC VE1 is suitable for screening purposes, but all negative, equivocal, and weak positive cases should be further tested with molecular biology techniques, of which the Idylla system seems to be a promising tool. (hindawi.com)
One of the mutations that has aroused considerable interest in recent years concerns the BRAF (v-raf murine sarcoma viral oncogene homolog B) gene that encodes the protein belonging to a highly oncogenic RAS/RAF/MEK/ERK signaling pathway [ 9 ]. (hindawi.com)
However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
Cancer results from the accumulation of mutations leading to the acquisition of cancer promoting characteristics such as increased proliferation and resistance to cell death. (biomedcentral.com)
Indeed, the phenotype seems to result from a complex interplay between the cell-intrinsic features and the acquired mutations, which is difficult to disentangle when established tumours are studied. (biomedcentral.com)
Murine gene mutations in human counterparts may be associated with a clinical illness different from the illness seen in mice. (medscape.com)

After injury, mature terminally differentiated kidney cells dedifferentiate into more primordial versions of themselves and then differentiate into the cell types needing replacement in the damaged tissue Macrophages can self-renew by local proliferation of mature differentiated cells. (wikipedia.org)
These cells, described as macrophages or immature dendritic cells, deplete arginine and impair T cell proliferation and cytokine production. (aacrjournals.org)
Cell separation studies showed that the increased arginase activity was limited to a specific subset of CD11b+, CD14−, CD15+ cells with a polymorphonuclear granulocyte morphology and markers, instead of macrophages or dendritic cells described in mouse models. (aacrjournals.org)
Finally, whereas SCF plus IL-7 promoted primarily granulopoiesis, the addition of TNF-alpha switched the differentiation toward the production of almost exclusively macrophages. (ox.ac.uk)

Myelomas are antibody-secreting tumor cells derived from terminally differentiated B lymphocytes, and previous work from our laboratory showed that murine SP2/0 myeloma cells and derived B-cell hybridomas were highly sensitive to apoptosis induction by a block of gene expression (cycloheximide). (aacrjournals.org)
The importance of apoptosis is exemplified by the vertebrate adaptive immune system, in which B lymphocytes, as they differentiate from their precursor cells, rearrange the DNA of immunoglobulin genes to generate a vast number of potential antibodies. (the-scientist.com)
In a very interesting chapter, Z. PANCER and M. D. COOPER first consider the emergence of lymphocytes as a novel circulatory cell type in vertebrates and then discuss phylogenetic aspects of the superfamily of LRR - containing proteins and their role in immunity. (scielo.br)
Immunotherapy based on the adoptive transfer of ex vivo expanded and activated autologous tumor-reactive lymphocytes can mediate tumor regression in cancer patients. (unimedizin-mainz.de)
Btk is required for the proliferation and differentiation of B lymphocytes. (medscape.com)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)

Next, an overview of several current models of hematopoietic lineage trees to identify developmental branching points between the lymphoid and myeloid cell compartments is discussed. (scielo.br)
Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. (nature.com)
Tumor necrosis factor-alpha (TNF-alpha) potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem cell factor and interleukin-7: novel stimulatory role of p55 TNF receptors. (ox.ac.uk)
TNF-alpha generally inhibits the growth of primitive murine hematopoietic progenitor cells (Lin-Scal+) in response to multiple cytokine combinations, and the p75 TNF receptor is essential in signaling such inhibition. (ox.ac.uk)
In contrast, TGF-beta 1, another bifunctional regulator of hematopoietic progenitor cell growth, completely blocked SCF plus IL-7-induced proliferation. (ox.ac.uk)
For example, in hematopoietic stem cells it was even shown that the same mutation can give rise to different phenotypes, creating two subsets of stem cells with opposing behaviour resulting from the same genetic event [ 18 ]. (biomedcentral.com)
MDS is rare in childhood and may have a rapidly progressive course with an extremely poor prognosis without hematopoietic stem cell transplantation (HSCT). (medscape.com)

Peripheral blood mononuclear cells from 123 patients with metastatic renal cell carcinoma, prior to treatment, were found to have a significantly increased arginase activity. (aacrjournals.org)

Oligodendrocyte progenitor cells (OPC) undergo asymmetric cell division (ACD) to generate one OPC and one differentiating oligodendrocyte (OL) progeny. (escholarship.org)

0.05), but not mature dendritic cells ( p = 0.132). (bmj.com)

They express several high molecular weight glycoprotein antigens that are down-regulated upon differentiation. (sigmaaldrich.com)
However, high-avidity T cells specific for tumor-associated antigens (TAAs) are usually absent in patients because of self-tolerance. (unimedizin-mainz.de)
Tumor-associated antigens (TAAs) are antigenic molecules that are unique to or highly expressed on tumor cells and absent or lowly expressed on healthy cells. (biocytogen.com.cn)

Tumor necrosis factor-alpha (TNF-alpha) is a bifunctional regulator of hematopoiesis, and its cellular responses are mediated by two distinct cell surface receptors. (ox.ac.uk)
In vitro , wogonoside decreased the production of pro-inflammatory cytokines like Nitric oxide (NO), prostaglandin E2 (PGE 2 ), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6). (oncotarget.com)

The expression of CSF-1R, a receptor important for myeloid cell migration, differentiation and survival, and the effect of its therapeutic blockade in the context of GVAX in PDAC has not been investigated. (bmj.com)
Jawed vertebrates (gnathostomes) generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragments, whereas jawless fish (agnathans) assemble diverse lymphocyte antigen receptor genes through the genomic rearrangement of leucine-rich repeat (LRR) - encoding molecules. (scielo.br)
These patients had a markedly decreased cytokine production and expressed low levels of T cell receptor CD3ζ chain. (aacrjournals.org)
In the present study we show the reverse phenomenon in that TNF-alpha on the same progenitor cell population in combination with stem cell factor (SCF) and interleukin-7 (IL-7) through the p55 TNF receptor can recruit additional progenitors to proliferate. (ox.ac.uk)
We also found that SRC-3 depletion in cultured HESCs results in a significant attenuation in the induction of a wide-range of established biomarkers of decidualization, despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. (frontiersin.org)
Receptor tyrosine kinases (RTKs) play fundamental tasks in varied cell functions including proliferation differentiation survival migration and rate of metabolism (16). (exposed-skin-care.net)
Using HLA-A2.1 transgenic mice, we have demonstrated the feasibility of T-cell receptor (TCR) gene transfer into T cells to circumvent self-tolerance to the widely expressed human p53 and MDM2 TAAs. (unimedizin-mainz.de)
TNFRSF9 (Tumor necrosis factor receptor super family, member 9), also called CD137 and 4-1BB, is a co-stimulatory molecule and is mainly expressed on the surface of T, B, NK and mononuclear cells. (biocytogen.com.cn)
SCR-6852, an oral and highly brain-penetrating estrogen receptor degrader (SERD), effectively shrinks tumors both in intracranial and subcutaneous ER + breast cancer models. (medscape.com)

Introduction: Glioma stem cells isolated from human glioblastomas are resistant to radiation and cytotoxic chemotherapy and may drive tumor recurrence. (nih.gov)
A study published in the Journal of Immunology suggests that the combined blockade of excess release of catecholamines (CAs) and prostaglandins (PGs) in cancer patients undergoing tumor excision might improve survival rates and prevent cancer recurrence. (brainimmune.com)
The study in the Journal of Immunology by Ariella Glasner and colleagues promotes the clinical testing of a new approach for reducing long-term cancer recurrence: blocking excessive perioperative paracrine and neuroendocrine stress responses, and specifically a combined blockade of excess release of CAs and PGs in the perioperative period in cancer patients undergoing tumor excision. (brainimmune.com)
In this study, the authors report that in mice, blocking beta-adrenoreceptors with propranolol and simultaneously inhibiting PG synthesis with etodolac signiﬁcantly improves recurrence-free survival rates following 3LL or B16 primary tumor excision. (brainimmune.com)
However, they are both clinically and histologically heterogeneous, and tumor recurrence or anaplastic progression occurs in some cases [ 6 ]. (hindawi.com)
Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)

Induced stem cells (iSC) are stem cells derived from somatic, reproductive, pluripotent or other cell types by deliberate epigenetic reprogramming. (wikipedia.org)
Progenitors are obtained by so-called direct reprogramming or directed differentiation and are also called induced somatic stem cells. (wikipedia.org)
Some types of mature, specialized adult cells can naturally revert to stem cells. (wikipedia.org)
While they normally produce digestive fluids for the stomach, they can revert into stem cells to make temporary repairs to stomach injuries, such as a cut or damage from infection. (wikipedia.org)
Moreover, they can make this transition even in the absence of noticeable injuries and are capable of replenishing entire gastric units, in essence serving as quiescent "reserve" stem cells. (wikipedia.org)
This capacity to regenerate does not decline with age and may be linked to their ability to make new stem cells from muscle cells on demand. (wikipedia.org)
A variety of nontumorigenic stem cells display the ability to generate multiple cell types. (wikipedia.org)
For instance, multilineage-differentiating stress-enduring (Muse) cells are stress-tolerant adult human stem cells that can self-renew. (wikipedia.org)
Treatment efficacy may depend on the presence of glioma stem cells, expression of DNA repair enzymes such as methylguanine methyltransferase (MGMT), or transcriptome subtype. (nih.gov)
Tumor initiation, development, and relapse may be closely associated with cancer stem cells (CSCs). (nature.com)
Human embryonal carcinoma (EC) cells are the stem cells of teratocarcinomas, and they are key components of germ cell tumors (GCTs). (sigmaaldrich.com)
This antibody reacts with TRA-1-60 antigen that is expressed upon the surface of human tetracarcinoma stem cells (EC), human embryonic germ cells (EG) and human embryonic stem cells (ES). (sigmaaldrich.com)
Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)
In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
In particular, stem cells are highly sensitive to extracellular signals that play a critical role in mainten- ance of stem cell characteristics, differentiation, and interplay with somatic cells. (unicyte.ch)
Myelodysplastic syndrome (MDS) in childhood encompasses a diverse group of bone marrow disorders that share a common clonal defect of stem cells and that result in ineffective hematopoiesis with dysplastic changes in the marrow. (medscape.com)
ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)
This strategy provides a useful tool for visualization and identification of neural progeny derived from human pluripotent stem cells. (lu.se)
We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)
Given this, human pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripo- tent stem cells (hiPSCs), have become a unique cell source for study- ing early human brain development. (lu.se)
However, current protocols for deriving neurons from human pluripotent stem cells give rise to heterogeneous cell populations both in regard to the temporal aspects and the cellular composition. (lu.se)
These strat- egies provide a robust way to visualize and isolate specific cell pop- ulations of differentiated pluripotent stem cells. (lu.se)
Here we describe how this system can be used for human embry- onic stem cells. (lu.se)

Immunoreactivity was limited to cells of melanocytic differentiation and no immunostaining was present in unrelated normal tissues and tumors. (nih.gov)
However, clear evidence for functional NK cell subsets exists in humans and the presence of NK cells in the thymus and immature NK cells in the liver suggests specific functions for NK cells in the tissues. (scielo.br)
In this review, we discuss the common and distinct metabolic profiles of Tregs in peripheral tissues and the TME, as well as the differences between Tregs and other conventional T cells in their metabolic preferences. (biomedcentral.com)
Some TAA targets are expressed in healthy tissues or cells and perform important physiological functions, and drugs directing against such targets may have serious toxic side effects. (biocytogen.com.cn)

Therapeutic response correlates with the mutational load of the patient tumors, suggesting that neoantigens contribute to tumor rejection. (unimedizin-mainz.de)

Comparing HESC controls with HESCs deficient in SRC-3, gene enrichment analysis of the differentially expressed gene set revealed an overrepresentation of genes involved in chromatin remodeling, cell proliferation/motility, and programmed cell death. (frontiersin.org)
Somatic cell genetic approaches in murine macrophage cell lines to mechanisms of growth inhibition, the oxidative burst, and expression of the chronic granulomatous disease gene. (grantome.com)
A safety concern of TCR gene transfer is the risk of pairing between introduced and the naturally expressed endogenous TCR chains, resulting in the generation of self-reactive T cells. (unimedizin-mainz.de)
We demonstrate that DBZ elicits a homogeneous goblet cell conversion all along the mouse intestinal tract, associated with an overexpression of the gene Muc2 without ectopic expression of the gastric genes Muc5ac and Muc6 , and with the emergence of lysozyme-positive 'intermediate cells' in the colon. (biologists.com)

In the pre-clinical murine model, administering anti-CSF-1R antibody prior to and after GVAX/αPD-1 ("pre/post-αCSF-1R + αPD-1 + GVAX") enhanced the survival rate compared to GVAX/αPD-1 dual therapy ( p = 0.005), but administering anti-CSF-1R only before GVAX/αPD-1 did not ( p = 0.41). (bmj.com)
Thus, the combination of propranolol and etodolac, but neither drug alone, significantly and markedly improved survival rates in both tumor models. (brainimmune.com)
KLF5 then acts as a molecular switch for p53 function by transactivating AKT1 and AKT3, which direct cells toward survival. (bvsalud.org)
Though early, these data buoy our confidence that AB821 fits our desired product profile as an IL-21 therapy that can selectively activate STAT3 signaling in CD8+ T cells to promote functionality, memory cell differentiation, and survival, all of which are complementary to the proliferation signal provided by IL-2 induced STAT5 activation. (pharmiweb.com)
However, children and adolescents, the oldest adult age group, cases diagnosed with anaplastic ependymoma and/or tumour location in a brain site had lowest survival rates. (cdc.gov)

Our studies also demonstrated that the in vitro differentiation capacity of MDSC is restricted to cells at the peripheral sites. (purdue.edu)
In vitro differentiation of murine erythroleuekemia cells recapitulates many aspects of the erythroid terminal differentiation program, including hemoglobin synthesis and proliferation arrest. (imrpress.com)

Consistent with this, MOC1-HPV K1 tumors had a lower percentage of hypoxic tumor area and a higher percentage of proliferating cells. (biomedcentral.com)

Sex cord-stromal tumors are groups of tumors composed of granulosa cells, theca cells, Sertoli cells, Leydig cells, and fibroblasts of stromal origin, singly or in various combinations. (medscape.com)
[ 1 ] sex cord-stromal tumors are classified into the following categories. (medscape.com)
Sex cord-stromal tumors account for approximately 8% of all ovarian tumors. (medscape.com)
Although various markers have been reported to stain sex cord-stromal tumors (eg, CD99, CD56, A103, müllerian inhibiting factor, vimentin), inhibin and calretinin have proven to be the most helpful to date. (medscape.com)
CD56 is a sensitive marker of ovarian sex cord-stromal tumors and may also be useful in the diagnosis of this group of neoplasms, especially in cases that are inhibin or calretinin negative, and the differential diagnosis includes neoplasms that are CD56 negative. (medscape.com)
We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)
These molecular findings are supported at the cellular level by the inability of HESCs to morphologically transform from a stromal fibroblastoid cell to an epithelioid decidual cell when endogenous SRC-3 levels are markedly reduced. (frontiersin.org)

The researchers were able to identify the minimal conditions and factors that would be sufficient for starting the cascade of molecular and cellular processes to instruct pluripotent cells to organize the embryo. (wikipedia.org)
They showed that opposing gradients of bone morphogenetic protein (BMP) and Nodal, two transforming growth factor family members that act as morphogens, are sufficient to induce molecular and cellular mechanisms required to organize, in vivo or in vitro, uncommitted cells of the zebrafish blastula animal pole into a well-developed embryo. (wikipedia.org)
The serine/threonine protein kinase BRAF is an important player in the mitogen-activated protein kinase (MAPK) signaling pathway that transduces mitogenic signals from activated cell-surface growth factor receptors to the cell nucleus and as a result modulates many important cellular processes, such as tumor growth, differentiation, proliferation, and angiogenesis. (hindawi.com)
Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
In normal cells, glucose participates in cellular energy production through glycolysis as well as through its complete catabolism via the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). (hindawi.com)
Previous work from the contributing DKTK partner sites has demonstrated the versatility of this approach in T cells, and showed that it is feasible to derive CAR-engineered, established human NK cells as an off-the-shelf cellular therapeutic. (unimedizin-mainz.de)
In this study, we investigated how higher-order chromatin structure modulates differential expression of the human INK4b-ARF-INK4a locus during progenitor cell differentiation, cellular ageing and senescence of cancer cells. (biomedcentral.com)
Expression of the INK4b-ARF-INKa locus during cellular ageing and differentiation . (biomedcentral.com)
WHO grade II tumours grouped as 'ependymoma' include cellular ependymoma, clear cell ependymoma, tanycytic ependymoma and papillary ependymoma. (cdc.gov)

These tumors, like most human cancers are poorly immunogenic, expressing no MHC-II and low levels of MHC-I. (brainimmune.com)
The introduction of HPV vaccines has also drawn more attention to the fact that HPV is associated not only with cervical cancer and genital warts but also with other tumors, such as head neck and anogenital cancers ( 3 ). (cdc.gov)
Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)

Signal transduction down the Ras/MAPK pathway, including that critical to T cell activation, proliferation, and differentiation, has been generally considered to occur at the plasma membrane. (scielo.br)
Development and homeostasis require the coordinate regulation of cell proliferation and differentiation. (biomedcentral.com)

They form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency and can differentiate into endodermal, ectodermal and mesodermal cells both in vitro and in vivo. (wikipedia.org)
Soluble Axl (sAxl) is present in cell-conditioned medium of CUDC-305 (DEBIO-0932 ) tumor cells growing in vivo and in vitro and in the sera of humans mice and rats (23 50 However the identities of the sAxl-generating protease(s) and the mechanism(s) that account for this process remain unknown. (exposed-skin-care.net)
In addition, tumor models were characterized in vivo in C57Bl/6NCrl mice in terms of their histological properties, tumor growth kinetics, and radiosensitivity. (biomedcentral.com)
MDSC that lack CAT2 have reduced capacity to suppress T cell responses both ex vivo and in vivo, as evidenced by increased T cell expansion in prostatitis and decreased tumor growth in cancer models. (purdue.edu)
and ultimately their functional role of resistance to virus infection and tumor cells in vivo. (grantome.com)
For studies of the role of NK cells in vivo, we will examine primary mouse and human tumors and metastases from the same individual for susceptibility to NK cells in both beige mice and nude mice immunosuppressed for NK activity and will characterize mechanism of resistance to the growth tumors and metastases by adoptive transfers with defined lymphocyte subpopulations. (grantome.com)

Flow cytometry analysis of tumor infiltrating T-cells in a murine model of PDAC was performed to investigate the therapeutic effects and mechanism of anti-CSF-1R/anti-PD-1/GVAX combination immunotherapy. (bmj.com)
Loss of pro-mitotic proteoglycan and OPC marker NG2 in the OL progeny is the earliest immunophenotypic change of unknown mechanism that indicates differentiation commitment. (escholarship.org)
Membrane vesicles, actively released by cells, represent a mechanism of intercellular communication that is conserved evolutionarily and involves the transfer of molecules able to induce epigenetic changes in recipient cells. (unicyte.ch)

Expression of the bcl-2 proto-oncogene has been shown to inhibit the apoptotic cell death of many types of cells. (aacrjournals.org)
B lymphoma Moloney murine leukemia virus insertion region 1 homolog (BMI-1) is an oncogene which functions by regulating P16 and P19 cell cycle inhibitor genes and is also associated with erythroplakia and tongue cancer. (cancertools.org)

Primary brain tumors include a number of histologic types with distinctly different tumor growth rates [ 4 , 5 ]. (hindawi.com)
PAs are a distinct histologic and biologic subset of gliomas that account for approximately 5.1% of all these tumors. (hindawi.com)
Furthermore, even when standardized treatment is used and tumors are at the same stage and have similar histologic features, it is difficult to predict the outcome. (cdc.gov)

Furthermore, DBZ treatment induces a heterogeneous reorganization of the crypt structural-proliferative units along the intestinal tract and of the stem cell niche in the colon, without disturbing the apoptotic compartment. (biologists.com)

These proteins were co-expressed by villous enterocytes only between weeks 14 and 20 post-conception, a time frame analogous to when they are expressed in the murine intestine. (nih.gov)
A common heterophilic ligand for these RTK family members is definitely Gas6 a vitamin K-dependent protein that is widely secreted by most cells including the lungs intestine Serping1 and vascular endothelium (43). (exposed-skin-care.net)
Following exposure to pathogens, the innate immune cells of gastrointestinal mucosa release pro-inflammatory cytokines and activate an adaptive immune response to aggravating inflammation in the intestine ( 3 ). (frontiersin.org)
However, it remains largely undefined to what extent the cell of origin determines the resulting tumour in the intestine. (biomedcentral.com)

Although NK precursors and immature NK cells have been identified in mice and humans, the precise sites where NK cell maturation take place are not yet fully defined. (scielo.br)
Clinical and cell-based studies as well as investigations on mice have demonstrated pivotal roles for each SRC in numerous physiological and pathophysiological contexts, underscoring their functional pleiotropy. (frontiersin.org)
and (c) Although IL-10 did not alter levels of anti-vaccinia antibodies or natural killer cell activity, rVV-primed mice treated with IL-10 had enhanced vaccinia-specific cytotoxic T-lymphocyte activity. (tech-strategy.org)
Enzyme-Linked Immunosorbent Assay Three groups of mice were vaccinated with either an i.v. injection of 1 1 107 PFU of VJS6 alone, 1 107 PFU of VJS6 followed by 5 days of recombinant murine IL-10 administration starting 12 hours after immunization (1 g, i.p. (tech-strategy.org)
Q.D.), or recombinant murine IL-10 administration alone (PeproTech, Inc.). Pooled sera from two immunized mice were obtained 2, 4, 6, 14, and 21 days after treatment and were analyzed by enzyme-linked immunosorbent assay for the presence of antibodies (Abs) against -gal protein or wild-type vaccinia virus. (tech-strategy.org)
The efficacy of these drugs can be evaluated via subcutaneous/in situ inoculation of TAA-humanized murine-derived cell lines in wild-type mice. (biocytogen.com.cn)
However, murine models, including knockout and transgenic mice, have been useful in understanding the mechanisms of B lymphopoiesis, B-cell differentiation, and antibody formation. (medscape.com)

Simultaneously, we decided to verify whether the combination of fully automated tests-BRAF-VE1 immunohistochemistry (IHC) and Idylla BRAF mutation assay-may be useful to accurately predict it in the case of specified CNS tumors. (hindawi.com)
Tumors from these patients will be used for peptide ligandome analyses, predictive in-situ biomarker analysis by immunohistochemistry, MALDI-TOF imaging mass spectrometry and RNA sequencing (RNAseq). (unimedizin-mainz.de)

Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. (lu.se)

For example, normal stroma, the connective material that supports the cells of a tissue, appears to inhibit cancer growth. (the-scientist.com)
GGs are well-differentiated, rare CNS tumors, which are characterized by a slow, circumscribed growth and a relatively favorable prognosis. (hindawi.com)
Although the cell lines did not differ in their intrinsic radiosensitivity, one of the HPV-positive tumor models, MOC1-HPV K1, showed a significantly longer growth delay after irradiation with a single dose of 15 Gy compared to parental MOC1 tumors. (biomedcentral.com)
Here, we investigated the effect of silibinin (a polyphenolic flavonolignan of the herbal plant of Silybum marianum, milk thistle) on the epidermal growth factor (EGF) ligand-induced CD44 expression in human breast cancer cells. (iiarjournals.org)
Growth factors may act either in an autocrine or a paracrine fashion and their temporal and spatial concentration modulates the cell phenotype and function. (unicyte.ch)

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) (also known as CD152) is a major negative regulator of T cell responses which interacts with the B7-1 (CD80) / B7-2 (CD86) ligands on the surface of an antigen-presenting cell. (scielo.br)
Notably, we identified p53 as a critical regulator of MDSC differentiation. (purdue.edu)

Chimeric antigen receptors (CAR)-engineered T cells have demonstrated remarkable efficacy in patients with B-cell malignancies. (unimedizin-mainz.de)
1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)

We discuss the contributions of PU.1 to the block to terminal differentiation exhibited by the erythroleukemia cells as well as the role of GATA-1 in restoring normal differentiation. (imrpress.com)

hESCs can be generated by SCNT using dermal fibroblasts nuclei from both a middle-aged 35-year-old male and an elderly, 75-year-old male, suggesting that age-associated changes are not necessarily an impediment to SCNT-based nuclear reprogramming of human cells. (wikipedia.org)

One example is the transformation of iris cells to lens cells in the process of maturation and transformation of retinal pigment epithelium cells into the neural retina during regeneration in adult newt eyes. (wikipedia.org)
The fact that transdetermination (change of the path of differentiation) often occurs for a group of cells rather than single cells shows that it is induced rather than part of maturation. (wikipedia.org)
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function. (ox.ac.uk)
Although defects may occur in many steps in B-cell development and maturation, resulting in agammaglobulinemia, the most common and well-described defect is the impaired maturation of the pro-B cells to pre-B cells. (medscape.com)

Previous work on this grant indicated that natural killer (NK) cells are heterogeneous and have a potentially important role to play in mediating rejection of virus infected cells and restricting metastases of tumor cells. (grantome.com)
Passage 2 heterogeneous cells were plated in a 6-well plate at 5 x 10 4 cells per well and grown overnight. (cancertools.org)

Molecular and cell biology of lipids, 2018. (ucla.edu)
Murine Axl is definitely cleaved extracellularly to generate a soluble ectodomain of approximately 65 kDa (23) whereas cleavage of human being Axl is definitely mapped to the 14-amino-acid (aa) stretch in the extracellular region and corresponds to the soluble CUDC-305 (DEBIO-0932 ) form with a higher molecular mass of 80 kDa (50). (exposed-skin-care.net)
Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)

Immune surveillance plays a major role in the defense against virus-associated tumors, where the virally encoded transforming proteins provide readily recognizable foreign targets. (the-scientist.com)
The normal function of the proteins expressed by these genes is to recognize superfluous, damaged, aged, or aberrant cells that must be eliminated. (the-scientist.com)
Several studies shown that Axl could mediate cell adhesion and aggregation through homotypic ectodomain associations (9 23 Both CUDC-305 (DEBIO-0932 ) murine and human being Axl proteins undergo proteolytic processing to yield a soluble form of this molecule. (exposed-skin-care.net)
Selective permeability of IECs is achieved by apical junctional complex (AJC) proteins which comprise tight junctions, adherens junctions, and desmosomes to maintain the apicobasal cell polarity and intestinal tissue integrity ( 4 ). (frontiersin.org)

Exosome/microvesicle-mediated epigenetic reprogramming of cells. (nature.com)
In the present review we focus on the extracellular vesicle-induced epigenetic changes in recipient cells that may lead to phenotypic and functional modifications. (unicyte.ch)
Similarly, reprogramming of somatic cells involves a complex interaction among intracellular and extracellular signals leading to epigenetic remodeling [6]. (unicyte.ch)

Vaccine strategies that concentrate on stimulating T cell immunity will at best generate reactive and persisting T cell responses that can suppress virus without preventing infection, limiting or preventing the damage the virus cause. (scielo.br)
A circulating subset of iNKT cells mediates antitumor and antiviral immunity. (ox.ac.uk)
Donor natural killer cells trigger production of beta-2-microglobulin to enhance post bone marrow transplant immunity. (ox.ac.uk)
Among them, Treg cells, which represent the master regulatory cells and participate in the maintenance of immune homeostasis, are regarded as the chief obstacle to antitumor immunity [ 18 ]. (biomedcentral.com)

We previously generated T311, a murine monoclonal antibody to the tyrosinase recombinant protein. (nih.gov)
Two monoclonal HPV-positive OSCC mouse cell lines were established by inducing the expression of HPV-16 oncogenes E6 and E7 in the MOC1 OSCC cell line using retroviral transduction. (biomedcentral.com)

To understand the genetic basis of this differential susceptibility, we examined the expression of apoptosis-related genes in these cell lines. (aacrjournals.org)
Northern blot experiments showed no significant difference in the expression of myc and bax apoptosis-promoting genes in susceptible (SP2/0 and D5) and resistant (P3X63) cell lines. (aacrjournals.org)
however, restoration of CBY1 expression in tumor cells reduces BCSC and its enrichment, thus lnc408 plays an essential role in maintenance of BCSC stemness. (nature.com)
Surgery markedly reduced NK cytotoxicity and NK cell expression of Fas ligand and CD11a, reduced all circulating lymphocyte-subtype concentrations, and increased corticosterone levels. (brainimmune.com)
After confirming stable expression of HPV-16 E6 and E7 with quantitative real-time PCR and immunofluorescence staining, the cell lines were further characterized in vitro using proliferation assay, wound healing assay, clonogenic assay and RNA sequencing. (biomedcentral.com)
The levels of CD44 mRNA and protein expression were greatly increased by EGF and by TGF-α in SKBR3 and BT474 breast cancer cells. (iiarjournals.org)
In a previous study, we also reported that 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression is inhibited by silibinin through inactivation of the RAF/MEK/ERK pathway ( 6 ), as well as augmenting the cell cycle arrest at the G 2 /M phase through the induction of p21 and the reduction of cyclin B1 in breast cancer cells ( 7 ). (iiarjournals.org)
In this study, we investigated the effect of silibinin on EGFR signaling pathway and EGF ligand-induced CD44 expression in breast cancer cells. (iiarjournals.org)
Characterized by the expression of the critical transcription factor forkhead box protein P3, regulatory T (Treg) cells are an essential part of the immune system, with a dual effect on the pathogenesis of autoimmune diseases and cancer. (biomedcentral.com)
Developmentally regulated EZH2 levels are one of the factors that can determine the higher order chromatin structure and expression pattern of the INK4b-ARF-INK4a locus, coupling human progenitor cell differentiation to proliferation control. (biomedcentral.com)
Our results suggest that although trisomy 8 cells are in a pro-apoptotic state, they are checked by the enhanced expression of anti-apoptotic signals which provide them with their proliferative advantage. (who.int)
Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
When a microRNA is present in the cell, it binds to the target sites and downregulates GFP expression, while in cells that do not express the microRNA GFP, it is expressed. (lu.se)

TAA-related drugs are able to kill tumor cells by mediating antibody-dependent cell-mediated cytotoxicity (ADCC)/complement-dependent cytotoxicitytest (CDC) and activating immune responses. (biocytogen.com.cn)

Focusing on advanced melanoma, we will investigate the antitumor activity of UniCAR NK cells in clinically relevant models. (unimedizin-mainz.de)

however, due to constitutive mTORC1 activation, these cells retained a terminally differentiated effector phenotype and were incapable of transitioning into a memory state. (jci.org)

Upon immobilization sAxl advertised cell migration and induced the phosphorylation of Axl and phosphatidylinositol 3-kinase. (exposed-skin-care.net)
By focusing on the critical roles of different metabolic programs, such as glycolysis, oxidative phosphorylation, fatty acid oxidation, fatty acid synthesis, and amino acid metabolism, as well as their essential regulators in modulating Treg proliferation, migration, and function, we hope to provide new insights into Treg cell-targeted antitumor immunotherapies. (biomedcentral.com)

The data source for incidence was the Central Brain Tumor Registry of the United States (CBTRUS) analytic file, 1995-2009. (cdc.gov)
Recently, in Finland, the United Kingdom, the Netherlands, the United States, and Sweden, incidence of OSCC has increased, and an increase in the proportion of HPV-positive tumors was noted. (cdc.gov)
We focus on the role of HPV in the increased incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer in which HPV is most commonly found ( 4 ). (cdc.gov)

Induced totipotent cells can be obtained by reprogramming somatic cells with somatic-cell nuclear transfer (SCNT). (wikipedia.org)
The process involves sucking out the nucleus of a somatic (body) cell and injecting it into an oocyte that has had its nucleus removed Using an approach based on the protocol outlined by Tachibana et al. (wikipedia.org)

NK cells coordinate tumor immunosurveillance and the immune response against pathogens. (scielo.br)
On the one hand, tumor cells are under immunosurveillance in the presence of various proinflammatory cells, such as CD8 + cytotoxic T cells, CD4 + type 1 helper T (Th1) cells, and natural killer cells. (biomedcentral.com)

Resistance to GVAX was associated with an immune-suppressive myeloid cell infiltration, which may limit further therapeutic gains of GVAX/αPD-1 therapy. (bmj.com)

We are pleased to announce two new development programs today, reflecting the versatility and broad applicability of our cis-targeting technology, as well as its ability to rapidly produce highly selective molecules that target two different cytokines to two different cell types," said Ivana Djuretic, Ph.D., Chief Scientific Officer and Co-founder of Asher Bio. (pharmiweb.com)
Promising combinations of UniCAR NK cells and distinct targeting molecules will be identified for subsequent translation into a phase clinical study. (unimedizin-mainz.de)
Growing evidence suggests that transcriptional regulators and secreted RNA molecules encapsulated within membrane vesicles modify the phenotype of target cells. (unicyte.ch)
CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)

However, in primary melanomas of the desmoplastic/spindle cell type, T311 revealed a poor immunoreactivity. (nih.gov)
Brain tumors are a diverse group of neoplasms arising from different cells within the CNS or from primary tumors of other organs that spread to the CNS. (hindawi.com)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)

Information exchange between cells coordinates devel- opment and functional interplay in complex organisms. (unicyte.ch)
In the absence of functional Btk, mature B cells that express surface Ig and the marker CD19 are few to absent. (medscape.com)

In an excellent issue, J.P. Di SANTO focuses on murine NK cells, although parallels to human NK cell biology are also made. (scielo.br)
The relevance of these phenomena in stem cell biology and tissue repair is discussed. (unicyte.ch)

Correction: Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy. (medscape.com)

Previously, wild-type IL-21 has demonstrated promising signs of efficacy in early clinical studies, but its utility has been hindered by toxicities and pleiotropic effects, such as suppression of antigen presentation in myeloid cells. (pharmiweb.com)
To meet the current market demand for the development of TAA-related drugs, Biocytogen has developed a set of humanized cell lines for efficacy evaluation. (biocytogen.com.cn)
The company has also developed humanized tumor cell lines according to the potential drug action mechanisms, so as to provide a more comprehensive and effective disease model for drug efficacy evaluation. (biocytogen.com.cn)

Anatomy42

Organisms14

Diseases48

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Phenomena and Processes54

Disciplines and Occupations1

Information Science3

Health Care1

Suppressor13

Anti-tumor6

Malignant7

Pathways9

Epithelial15

Microenvironment6

Metastasis6

Regulate4

Mutations11

Macrophages4

Lymphocytes6

Hematopoietic7

Metastatic1

Progenitor cells1

Dendritic cells1

Antigens3

Necrosis factor-alpha2

Receptor9

Recurrence6

Stem cells24

Tissues4

Contribute to tumor1

Gene4

Survival5

Vitro differentiation2

Hypoxic tumor1

Stromal7

Cellular9

Cancers3

Proliferation and differentiation2

Vivo6

Mechanism3

Oncogene2

Histologic3

Induces1

Intestine4

Mice7

Immunohistochemistry2

Pluripotent cells1

Growth5

Regulator2

Receptors2

Terminal differentiation1

Fibroblasts1

Maturation4

Heterogeneous2

Molecular3

Proteins4

Epigenetic3

Immunity4

Monoclonal2

Expression13

Antibody1

Clinically1

Terminally differentiated1

Migration2

Incidence3

Somatic2

Immunosurveillance2

Myeloid cell1

Molecules4

Primary3

Functional2

Biology2

Chemotherapy1

Efficacy3