• Taken together, our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and that HDAC inhibitor-mediated apoptosis operates at least in part through reactivation of this pathway. (nature.com)
  • [ 6 ] NF-KB protects cells from apoptosis in response to tumor necrosis factor-alpha (TNF-alpha). (medscape.com)
  • In the skin, NF-KB regulates cell growth in the stratified epithelium and apoptosis. (medscape.com)
  • Furthermore, TBK1 is also involved in the regulation of cell proliferation, apoptosis and glucose metabolism. (wikipedia.org)
  • It is reportedly involved in many physiological functions of cells, including apoptosis, proliferation, invasion and angiogenesis ( 5 ). (spandidos-publications.com)
  • In subsequent experiments, when we treated the tumor cells with drugs that target the pathway activated by the mutated gene, the cells underwent apoptosis, or programmed cell death. (sciencedaily.com)
  • When we shut down the pathway by blocking the abnormal protein with drug molecules, the tumor cells entered apoptosis. (sciencedaily.com)
  • Unexpectedly, this molecule promotes a caspase-dependent apoptosis that is unusual in the P-glycoprotein-overexpressing cells. (torvergata.it)
  • Interestingly, leukemia MDR1-expressing cells show lower LC50 values and a higher degree of apoptosis and caspase-3 activity than their drug-sensitive counterparts. (torvergata.it)
  • 2006). A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells - 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells. (torvergata.it)
  • Western blot analysis was performed to study Boswellia sacra essential oil-regulated proteins involved in apoptosis, signaling pathways, and cell cycle regulation. (biomedcentral.com)
  • Boswellia sacra essential oil hydrodistilled at 100 o C was more potent than the essential oil prepared at 78 o C in inducing cancer cell death, preventing the cellular network formation (MDA-MB-231) cells on Matrigel, causing the breakdown of multicellular tumor spheroids (T47D cells), and regulating molecules involved in apoptosis, signal transduction, and cell cycle progression. (biomedcentral.com)
  • 24h after TCR transduction, CD107a expression correlated with low expansion rates due to apoptosis of ADRB3 specific T cells in contrast to CHM1 specific transgenic T cells. (oncotarget.com)
  • these oncomodulatory viruses can alter the pathology of these tumors by affecting cell signaling, cell metabolism, apoptosis mechanisms, cell-cell communication, inflammation, antitumor immunity suppression, and angiogenesis. (surgicalneurologyint.com)
  • Oncomodulation is a process, whereby tumor behavior is affected by virally induced mechanisms acting on cancer cells as well as stromal cells within the tumor microenvironment, including suppression of cancer cell apoptosis mechanisms, altering tumor metabolism, suppressing antitumor immunity, triggering tumor microenvironment inflammation, initiating angiogenesis, stimulating tumor cell proliferation, increasing tumor invasion, and enhancing tumor cell migration (metastasis) [ Figures 1 and 2 ]. (surgicalneurologyint.com)
  • Studies have found that miRNA can affect a variety of biological effects, such as DNA damage repair, cell cycle arrest, cell hypoxia, proliferation and apoptosis, etc. (researchsquare.com)
  • It has complex functions and can inhibit cell apoptosis, promote cell transformation, participate in cell mitosis, angiogenesis, and cause tumor cells to develop drug resistance [ 7 , 8 ] . (researchsquare.com)
  • Normally, these cells are eliminated by apoptosis. (medscape.com)
  • Literature suggests that the only known risk factor for extragonadal germ cell tumors (EGCTs) is Klinefelter syndrome (47XXY), which is associated with mediastinal nonseminomatous germ cell tumors. (medscape.com)
  • In extragonadal germ cell tumors, no evidence of a primary malignancy is present in either the testes or ovaries by radiologic imaging or physical examination. (medscape.com)
  • Extragonadal germ cell tumors produce a rich symptomatology and may reach large volumes if they arise in silent areas. (medscape.com)
  • Controversy remains regarding the origin of extragonadal germ cell tumors (EGGCTs). (medscape.com)
  • The classic theory suggests that germ cell tumors (GCTs) in these areas are derived from local transformation of primordial germ cells misplaced during embryogenesis. (medscape.com)
  • According to this theory, the differences in phenotypes expressed by mediastinal germ cell tumors (MGCTs) and gonadal germ cell tumors may be explained by differences in the cellular environment between the gonad and the anterior mediastinum. (medscape.com)
  • Some retroperitoneal extragonadal germ cell tumors may represent metastases from a testicular cancer , with subsequent spontaneous necrosis of the primary tumour. (medscape.com)
  • Hematologic malignancies are frequently associated with mediastinal germ cell tumors. (medscape.com)
  • Highly differentiated yolk-sac tumors make up 30% of mediastinal germ cell tumors, providing a possible basis for this association. (medscape.com)
  • The balance of the p53-mdm2 interaction has been shown to be disrupted in intracranial germ cell tumors (ICGCTs). (medscape.com)
  • The mediastinum is the most common site of extragonadal germ cell tumors. (medscape.com)
  • Mediastinal germ cell tumors account for only 2-5% of all germinal tumors, but they constitute 50-70% of all extragonadal tumors. (medscape.com)
  • Mediastinal germ cell tumors account for 1-15% of adult anterior mediastinal tumors. (medscape.com)
  • Mature teratomas represent 60-70% of mediastinal germ cell tumors. (medscape.com)
  • Although 90-100% of malignant germ cell tumors are symptomatic, only 50% of teratomas produce symptoms. (medscape.com)
  • Nonseminomatous mediastinal germ cell tumors (NS-MGCTs) are faster growing and metastasize earlier than mediastinal seminomas. (medscape.com)
  • Distant metastases are seen only in malignant mediastinal germ cell tumors. (medscape.com)
  • Mature teratoma rupture, teratoma with malignant transformation, and hematologic malignancies may complicate mediastinal germ cell tumors (see Complications). (medscape.com)
  • The second most common site of extragonadal germ cell tumors (30-40%), after the mediastinum, is the retroperitoneum. (medscape.com)
  • Retroperitoneal germ cell tumors (RGCTs) represent 10% of all malignant primary retroperitoneal tumors. (medscape.com)
  • Often patients with retroperitoneal germ cell tumors present late, after their tumors have reached large dimensions. (medscape.com)
  • Very rare tumors of the adolescent and young adult, intracranial germ cell tumors (ICGCTs) are localized preferentially to the pineal and suprasellar regions. (medscape.com)
  • Although seminomas (60% of intracranial germ cell tumors) have a predilection for the suprasellar region, embryonal carcinomas, yolk-sac tumors, and choriocarcinomas mainly occur in the pineal region. (medscape.com)
  • Update on testicular germ cell tumors. (cdc.gov)
  • Familial testicular germ cell tumors (FTGCT) - overview of a multidisciplinary etiologic study. (cdc.gov)
  • In addition, whereas weak pre-existing immunity did not alter the protective thresholds of the vaccine-specific T cell response following subsequent immunization with CMV-based vaccine vectors, strong pre-existing immunity inhibited the development of vaccine-induced T cells and their control on tumor progression. (bmj.com)
  • Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity. (amedeo.com)
  • This observation underscores the point that the tumor-bearing host may not provide an appropriate environment to prime anticancer immunity. (biomedcentral.com)
  • While HIF1A acts as a tumor suppressor and is frequently lost through inactivating mutations/14q chromosome deletions, HIF2A acts as an oncogene promoting the expression of its target genes (VEGF, PDGF, CAIX Oct4, among others). (gencat.cat)
  • The present study examines effects of metallic nickel particles on tumor promoter or suppressor genes and its signal transduction pathways in JB6 cells. (cdc.gov)
  • Carriers of germinal VHL mutations have an increased prevalence of kidney cysts and ccRCC as well as hemangioblastoma, pheochromocytoma and pancreatic neuroendocrine tumors. (gencat.cat)
  • PURPOSE: The finding of mTOR overactivation in patients affected by pancreatic neuroendocrine tumors (Pa-NETs) led to their treatment with the mTOR inhibitor everolimus. (bvsalud.org)
  • Waldenström's macroglobulinemia is a slow-growing form of non-Hodgkin lymphoma that originates in white blood cells known as B lymphocytes. (sciencedaily.com)
  • CD4 Phenotypes Are Associated with Reduced Expansion of Tumor-Infiltrating Lymphocytes in Melanoma Patients Treated with Adoptive Cell Therapy. (amedeo.com)
  • Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells. (southernbiotech.com)
  • A cell-surface molecule involved in organ-specific homing of lymphocytes. (southernbiotech.com)
  • Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes. (southernbiotech.com)
  • T-cell-receptor-independent activation of cytolytic activity of cytotoxic T lymphocytes mediated through CD44 and gp90 MEL-14 . (southernbiotech.com)
  • Chemo-radio therapeutic outcomes are poor in CCA patients because the tumor is highly desmoplastic with fibrogenic connective tissue and immune cells such as T lymphocytes, natural killer (NK) cells and macrophages that infiltrate the tumor epithelium [ 4 ]. (aging-us.com)
  • Moreover, pro-tumor TAMs contribute to tumor growth by inhibiting tumor-infiltrating lymphocytes (TILs) that target tumor cells. (lu.se)
  • Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice xenografted with Lewis lung carcinoma (LLC) cells. (frontiersin.org)
  • The results showed that lycopene reduced the number of metastatic tumors in the lungs, which was further suppressed by the combined treatment with sorafenib. (frontiersin.org)
  • In anti-metastatic studies, lycopene has been found to inhibit the metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice ( 17 ). (frontiersin.org)
  • Tumor cells in the blood of patients with metastatic carcinomas are associated with poor survival. (biomedcentral.com)
  • The patient samples came from 10 patients with metastatic small cell lung cancer or metastatic non-small-cell lung cancer. (biomedcentral.com)
  • Many of these cell lines have been obtained from a highly metastatic malignant tumor of the trophoblast, the choriocarcinoma, and have been extensively characterized. (biomedicineandprevention.com)
  • One special subgroup comprises patients with limited tumor spread lying between localized early breast cancer and disseminated metastatic cancer, termed oligometastatic disease. (springer.com)
  • In order to cure metastatic disease, several approaches are imaginable: (1) locoregional treatment of the primary tumor and all metastatic sites, (2) tumor eradication by excellent systemic anticancer therapy, (3) long-term immunologic tumor control induced by immunotherapy or (4) the combination of these approaches. (springer.com)
  • Methods: CellSearch® images (N = 272) of either CTCs or white blood cells or artifacts from 109 non-metastatic (M0) and 22 metastatic (M1) breast cancer patients from reported studies were sent to 22 readers from 15 academic laboratories and 8 readers from two Veridex laboratories. (utwente.nl)
  • Previous research has demonstrated that TAMs located in close proximity to tumor vessels (perivascular TAMs) promote vessel abnormalization and facilitate metastatic dissemination. (lu.se)
  • NF-KB is important in immune, inflammatory, and apoptotic pathways. (medscape.com)
  • The CYLD gene provides instructions for making an enzyme that helps regulate numerous signaling pathways, many of which are involved in cell growth. (medlineplus.gov)
  • Medulloblastoma (MB) is a malignant embryonal brain tumour originating from neural stem cells or granule-cell progenitors of the cerebellum, due to a deregulation of signalling pathways involved in neuronal development such as Wnt or Sonic Hedgehog (SHH) [ 1 ]. (biomedcentral.com)
  • Our observations suggest that the tumor paracrine effect affects biological pathways of pleurodesis. (medscimonit.com)
  • The clustering of cases and association of the tumors with the olfactory pathways suggested an infectious cause with a distinct route of transmission and tropism. (cdc.gov)
  • In the current study, the anti‑invasive activities and associated signaling pathways of celastrol were determined in ovarian cancer cells. (spandidos-publications.com)
  • Since it is known that inhibition of cell death mechanisms is a common event in tumour development, this poses problems for many forms of chemotherapy that utilise cell death pathways, leading to drug resistance. (gla.ac.uk)
  • Consistently, the essential oil represses signaling pathways and cell cycle regulators that have been proposed as therapeutic targets for breast cancer. (biomedcentral.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Functional enrichment analysis of the DEGs in the high OSM-expressing CCA tissues showed that pathways related to tumor progression and immune response were significantly upregulated. (aging-us.com)
  • During the metastasis, cancer cells in situ move to other tissues and organs from the blood circulation or the lymphatic system through proliferation, adhesion, invasion, and migration. (frontiersin.org)
  • Cell proliferation and invasion were assayed using the kidney cell lines HEK293 with wild-type p53 and a ccRCC cell line MZ1257RC mutated for p53. (frontiersin.org)
  • HEK293 cells demonstrated a restriction of ERV-K113 env expression and invasion with no changes in proliferation in the absence of Aza. (frontiersin.org)
  • Open in a separate window Fig. 4 EVs shed by renal cancer cells inhibited monocyte-derived DC differentiation and their ability to stimulate T cell proliferation. (woofahs.com)
  • Cell proliferation was tested by MTT assay. (spandidos-publications.com)
  • PGE2 activation of JAK2/STAT3 acting on genes controlling tumor invasion/migration, cell proliferation, angiogenesis, and initiating immune suppression is demonstrated. (surgicalneurologyint.com)
  • Subsequently, we assessed the impact of NF-κB and STAT3 inhibitors in QGP-1 cell proliferation and spheroids growth. (bvsalud.org)
  • NF-kB p65 and STAT3 inhibitors decrease QGP-1 viability, spheroids growth, and Pa-NETs cell proliferation. (bvsalud.org)
  • Extragonadal germinal cell syndromes are rare tumors that predominantly affect young males. (medscape.com)
  • We believe that this mechanism for disarming macrophages develops early in cancer cells, enabling small tumors to survive and grow," adds Guttridge, who also is in the OSUCCC - James Molecular Carcinogenesis and Chemoprevention Program. (medicalxpress.com)
  • Those arising in nonvital organs can reach large sizes before becoming symptomatic, but small tumors may result in significant symptoms if they obstruct, compress, or rupture into important structures. (medscape.com)
  • For a targeted therapy to be effective, its target needs to be present in the tumor cells. (biomedcentral.com)
  • We have identified a candidate etiologic agent, dubbed raccoon polyomavirus, that was present in the tumor tissue of all affected animals but not in tissues from 20 unaffected animals. (cdc.gov)
  • aDNA for ancient DNA, CancerCL for cancer, tumor, other abnormal tissues, or cell line studies (include cybrids), and Main for the rest. (mitomap.org)
  • Very early during mammalian development the embryo differentiates into 2 main cell lineages, the inner cell mass (ICM) which will mainly contribute to embryonic tissues, and the trophoblast which will form extra-embryonic tissues. (biomedicineandprevention.com)
  • We identified 96 differentially expressed genes (DEGs), including 13 upregulated and 83 downregulated genes, in CCA tissues as regulatory T cells were significantly higher and the proportions of activated natural killer cells and monocytes were significantly lower in CCA tissues than the precancerous tissues. (aging-us.com)
  • CCA patients with a higher proportion of neutrophils and T-regulatory cells (Tregs) and lower proportion of CD8 + T cells in the tumor tissues are associated with poor prognosis [ 5 ]. (aging-us.com)
  • However, only limited types of tumor-infiltrating immune cells have been analyzed in CCA tissues and the mechanisms regulating the tumor infiltration of immune cells are poorly understood. (aging-us.com)
  • Recent studies demonstrate that somatic mutations in the tumor tissues influence immunotherapeutic response in several cancers [ 6 , 7 ]. (aging-us.com)
  • We applied a range of molecular and cellular techniques to measure cell survival, cell cycle progression, protein expression and DNA damage combined with a transcriptomic micro-array approach in D283-MED cells, for global gene expression analysis in acute and chronic hypoxic conditions. (biomedcentral.com)
  • Activator protein-1 (AP-1) and nuclear factor-kB (NF-kB) have been shown to play pivotal roles in tumor initiation, promotion, and progression. (cdc.gov)
  • CONCLUSION: Since the NF-kB pathway is implicated in Pa-NETs' progression and resistance to everolimus, these data could explain the potential use of NF-kB as a novel therapeutic target in Pa-NET patients. (bvsalud.org)
  • With regard to cancer treatment, celastrol has been shown to exert considerable cell-killing effects and to shrink xenografted tumors in tissue and animal models of various malignancies including cancers of the prostate ( 16 - 18 ), breast ( 19 ), liver ( 20 , 21 ) and lung ( 22 , 23 ). (spandidos-publications.com)
  • 7. Diamant E, Keren Z, Melamed D. CD19 regulates positive selection and maturation in B lymphopoiesis: lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing. (southernbiotech.com)
  • Nivedita M. Ratnam et al, NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development, Journal of Clinical Investigation (2017). (medicalxpress.com)
  • We have now identified a unique pathway that regulates the pro-tumor functions of TAMs, offering potential for the development of novel anti-cancer targets. (lu.se)
  • When macrophages take up Gdf-15, it prevents them making nitric oxide and tumor necrosis factor , two chemicals they release to kill cancer cells. (medicalxpress.com)
  • Ironically, the researchers found that NF-kB in macrophages plays an important role in the production of nitric oxide and tumor necrosis factor. (medicalxpress.com)
  • BZK induced a significant increase in the severity of the clinical score, infiltration of inflammatory cells, local expression of inflammatory cytokines in subcutaneous tissue, and total serum immunoglobulin (Ig) E. PVP-I increased the clinical score, number of mast cells, and production of inflammatory cytokines, and total serum IgE. (medsci.org)
  • Research has intensified to understand ERV protein function and their role as tumor antigens and targets for cancer (immune) therapy. (frontiersin.org)
  • Study therapy included two cycles of docetaxel 75 mg/m 2 on days 1 and 29 to treat the tumor, release hidden antigens and produce lymphopenia. (biomedcentral.com)
  • All 4 patients had evidence of specific antibody responses against potential tumor antigens. (biomedcentral.com)
  • In addition to mutated proteins, NSCLC can over-express a number of non-mutated proteins that can induce both humoral and cytotoxic T cell responses [ 10 ], and also have the potential to serve as tumor rejection antigens [ 11 ]. (biomedcentral.com)
  • Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)
  • Moreover, we recently reported that lycopene inhibits the metastasis of human liver adenocarcinoma SK-Hep-1 cells by downregulation of the NADPH oxidase 4 (NOX4) proteins ( 18 ). (frontiersin.org)
  • Forced expression of HOTAIR in epithelial cancer cells induces genome-wide Polycomb repression complex 2 (PRC2) to retarget to a more similar pattern of embryonic fibroblasts, leading to gene expression changes, and increase cancer invasion and metastasis. (biomedcentral.com)
  • To better design treatments for cancer, it is important to understand the heterogeneity in tumors and how this contributes to metastasis. (pharmaceuticalintelligence.com)
  • The addition of mediators secreted by adenocarcinoma altered the inflammatory response of the mesothelial cells to sclerosing agents. (medscimonit.com)
  • An addition of soluble factors produced by adenocarcinoma altered the inflammatory response of the pleural mesothelial cells after stimulation with sclerosing agents. (medscimonit.com)
  • Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that occurs when a person's immune system attacks healthy cells in the body. (medicaldaily.com)
  • Et-OH increased the clinical score and number of inflammatory cells, but showed no effect on serum IgE levels. (medsci.org)
  • 8. Løvås T, Bruusgaard JC, Øynebråten I, Gundersen K, Bogen B. DNA vaccines: MHC II-targeted vaccine protein produced by transfected muscle fibres induces a local inflammatory cell infiltrate in mice. (southernbiotech.com)
  • In this respect, NF-κB and STAT3 interaction is implicated in the crosstalk between inflammatory and tumor cells. (bvsalud.org)
  • Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma. (nih.gov)
  • Defined immune thresholds for tumor protection and the factors affecting such thresholds have not well been investigated in cancer immunotherapy. (bmj.com)
  • Retargeting IL-2 Signaling to NKG2D-Expressing Tumor-Infiltrating Leukocytes Improves Adoptive Transfer Immunotherapy. (amedeo.com)
  • This study was designed to test a novel immunotherapy strategy using a vaccine enriched for short-lived proteins (SLiPs) and defective ribosomal products (DRiPs) derived from autologous tumor cells. (biomedcentral.com)
  • Medulloblastoma (MB) is the most common malignant brain tumour in children. (biomedcentral.com)
  • Raccoon polyomavirus may contribute to the development of malignant brain tumors of raccoons. (cdc.gov)
  • The metastasizing cells penetrate the blood vessel wall by invasiveness, and migrate in the circulation, extravasate out of the blood vessels, colonize in the distant tissue, initiate angiogenesis, and finally grow at the new site ( 2 , 3 ). (frontiersin.org)
  • A new study by researchers at The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute (OSUCCC - James) identifies a substance released by pancreatic cancer cells that protects them from attack by immune cells called macrophages. (medicalxpress.com)
  • A novel p53-derived apoptotic peptide de-represses p73 to cause tumor regression in vivo. (gla.ac.uk)
  • Using optimized single-cell multiomics sequencing together with multiregional sampling of the primary tumor and lymphatic and distant metastases, we developed insights beyond intratumoral heterogeneity. (pharmaceuticalintelligence.com)
  • 1996). Expression of Egr-1 correlates with the transformed phenotype and the type of viral latency in EBV genome positive lymphoid cell lines. (nature.com)
  • The efficiency of the procedure was determined by spiking blood with SKBR-3 cells, enrichment with the CellSearch system, followed by single cell sorting by fluorescence-activated cell sorting (FACS) and whole genome amplification. (biomedcentral.com)
  • Southern blot hybridization and rolling circle amplification showed the episomal viral genome in the tumors. (cdc.gov)
  • Background The capacity of cytomegalovirus (CMV) to elicit long-lasting strong T cell responses, and the ability to engineer the genome of this DNA virus positions CMV-based vaccine vectors highly suitable as a cancer vaccine platform. (bmj.com)
  • The discovery was made by sequencing the genome of tumor cells in Waldenström's patients, reading the cells' DNA letter by letter, and seeing where it differed from that of the patients' normal cells. (sciencedaily.com)
  • For the current research, Treon and his colleagues conducted whole genome sequencing of tumor cells and normal cells from 30 patients with Waldenström's. (sciencedaily.com)
  • The genome-wide DNA demethylation patterns of cancer cells were consistent in all 10 patients whose DNA we sequenced. (pharmaceuticalintelligence.com)
  • Multi-stage genome-wide association study identifies new susceptibility locus for testicular germ cell tumour on chromosome 3q25. (cdc.gov)
  • Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. (nature.com)
  • Suárez C, Vieito M, Valdivia A, González M, Carles J. Selective HIF2A Inhibitors in the Management of Clear Cell Renal Cancer and Von Hippel–Lindau-Disease-Associated Tumors. (gencat.cat)
  • Spiradenomas are related to cylindromas and it is common to find features of both of these benign growths in a single tumor. (medlineplus.gov)
  • More recently, tumour-treating fields therapy (TTFields) has demonstrated modest survival benefit and been clinically approved in several countries. (nature.com)
  • Renal cell carcinoma (RCC) is one of the ten most common cancers for men and women with an approximate 75% overall 5-year survival. (frontiersin.org)
  • High ERV-K env total protein expression of all tumor subtypes significantly correlated with low tumor grading and a longer disease specific survival using multivariable analyses. (frontiersin.org)
  • This study supports ERV-K env as a single prognostic indicator for better survival of RCC, which we propose represents a new tumor antigen. (frontiersin.org)
  • As a consequence, p53 activation by etoposide was reduced, and cell survival enhanced. (biomedcentral.com)
  • Due to the role of TBK1 in cell survival, deregulation of its activity is associated with tumorogenesis. (wikipedia.org)
  • The mutation causes the cells to produce a distorted protein, which switches on the IRAK complex pathway, leading to activation of NF-kB, a protein that is essential for the growth and survival of Waldenström's tumor cells," Treon comments. (sciencedaily.com)
  • Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity. (gla.ac.uk)
  • Furthermore, tumor eradication by excellent systemic anticancer therapy with novel chemotherapies and targeted agents can lead to long-term survival. (springer.com)
  • Liu Q , Lan T , Song Y , Cai J , Yu X , Chen W , . Oncostatin M expression and TP53 mutation status regulate tumor-infiltration of immune cells and survival outcomes in cholangiocarcinoma. (aging-us.com)
  • In this study, we used bioinformatics tools to analyze transcriptome data from cholangiocarcinoma (CCA) patients in multiple datasets (Sun Yat-sen University, TCGA and GSE32225 cohorts) to identify mechanisms that regulate tumor infiltration by immune cells and survival outcomes. (aging-us.com)
  • The survival outcomes of CCA patients were associated with the TP53 gene mutation status, levels of Oncostatin M (OSM) expression, and the proportions of tumor-infiltrating immune cell types, including dendritic cells, monocytes, and T follicular helper cells. (aging-us.com)
  • Our study demonstrates that OSM expression and TP53 mutation status regulate the tumor infiltration by immune cells and survival outcomes in CCA. (aging-us.com)
  • used a single-cell triple omics sequencing (scTrio-seq) technique to examine the mutations, transcriptome, and methylome within colorectal cancer tumors and metastases from 10 individual patients. (pharmaceuticalintelligence.com)
  • JCV, for example, induces brain tumors when intracerebrally inoculated in experimental animals ( 7 - 11 ). (cdc.gov)
  • Similar to our previous observations in human bladder cancer cells, Boswellia sacra essential oil induces breast cancer cell-specific cytotoxicity. (biomedcentral.com)
  • In normal cells, mdm2 availability is controlled by ARF, the product of the p14ARF gene located on INK4a/ARF locus, which binds with mdm2 and induces its degradation. (medscape.com)
  • For example, matrix metalloproteinases (MMPs), such as MMP-2 and −9, have been shown to be typical NF-κB target proteins that are responsible for extracellular matrix breakdown and cell invasion ( 7 ). (spandidos-publications.com)
  • Drugs that block the abnormal protein or other proteins in the NF-kB pathway could, theoretically, short-circuit the disease process in many patients. (sciencedaily.com)
  • We are investigating both known cell death regulators as well as searching for novel proteins that control cell death and chemosensitivity. (gla.ac.uk)
  • Tumor cells were cultured in vitro with the proteasome inhibitor bortezomib, which stabilizes SLiPs and DRiPs, shunting proteins into the autophagy pathway [ 12 ]. (biomedcentral.com)
  • Oncomodulatory viruses, such as human cytomegaloviruses (HCMV), are known to release over 200 proteins, many of which can alter tumor behavior [ Table 1 ]. (surgicalneurologyint.com)
  • NCMV proteins and their oncogenic effects on cell mechanisms. (surgicalneurologyint.com)
  • Rather, only a few cells need to be infected, with the release of viral proteins from the viruses, which occupy most if not all of the tumor cells, including stromal cells. (surgicalneurologyint.com)
  • The blood circulating miRNA is mainly derived from a type of exosomes containing a variety of proteins and miRNAs that can be passed between cells and endocytic vesicles. (researchsquare.com)
  • Recent advances have been made by an accumulation of studies on Merkel cell polyomavirus (MCPyV), which is highly associated and integrated in most Merkel cell carcinomas ( 5 ). (cdc.gov)
  • Overall," Guttridge says, "our results reveal that NF-kB is responsible for the synthesis and secretion of GDF-15 from pancreatic tumor cells, and that GDF-15 then inhibits NF-kB activity in macrophages and blocks them from killing tumor cells. (medicalxpress.com)
  • Tumor-associated macrophages (TAMs) are dynamic cells displaying a spectrum of states and phenotypes ranging from antitumor/immunostimulating (often termed M1-like) to protumor/immunosuppressive (also known as M2-like). (lu.se)
  • Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)
  • Using transcriptomic analysis in D283-MED cells, we found a large transcriptional remodelling upon long term hypoxia, in particular the expression of a number of genes involved in detection and repair of double strand breaks (DSB) was altered. (biomedcentral.com)
  • [ 1 ] ETP-ALL frequently has mutations in RUNX1 and/or ETV6 in addition to genes that are more commonly associated with myeloid neoplasms and are otherwise rare in T-cell lymphoblastic leukemia/lymphoma (such as FLT3 , IDH1/2 , TET2 , and DNMT3A mutations). (medscape.com)
  • In this study, we report a central role of the transcription factor, early growth response-1 (EGR1), in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. (nature.com)
  • 1998). p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. (nature.com)
  • 2004). Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma. (nature.com)
  • CYLD cutaneous syndrome is a genetic condition characterized by the growth of multiple noncancerous (benign) skin tumors. (medlineplus.gov)
  • However, enough enzyme is usually produced from the remaining, normal copy of the gene to regulate cell growth effectively. (medlineplus.gov)
  • The loss of CYLD enzyme in different types of cells, especially those in structures in the skin, leads to the growth of a variety of tumors. (medlineplus.gov)
  • Using intra-exosomal metabolomics, we provide compelling evidence that CDEs contain intact metabolites, including amino acids, lipids, and TCA-cycle intermediates that are avidly utilized by cancer cells for central carbon metabolism and promoting tumor growth under nutrient deprivation or nutrient stressed conditions. (elifesciences.org)
  • PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma. (amedeo.com)
  • Mannose impairs tumour growth and enhances chemotherapy. (gla.ac.uk)
  • This is very important to the growth and death of cells. (ed.ac.uk)
  • The first suggests that fetal gonocytes whose development into spermatogonia is blocked may undergo abnormal cell division and then invasive growth mediated by postnatal and pubertal gonadotrophin stimulation. (medscape.com)
  • n suprasellar tumors, precocious pseudopuberty, diabetes insipidus with or without anterior pituitary dysfunctions (eg, adrenocorticotropic hormone [ACTH] deficiency), central hypothyroidism, growth hormone (GH) deficiency, and hypogonadism may be seen. (medscape.com)
  • Sixteen histological tumor subtypes exist and the most common are papillary, chromophobe and clear cell renal cell carcinoma (ccRCC) representing 85% of all RCC. (frontiersin.org)
  • Conclusions In conclusion, the results of the present study indicate that renal cancer cells and in particular CSCs and derived EVs impair maturation of DCs and T cell immune response by a mechanism involving HLA-G. Electronic supplementary material The online version of this article (doi:10.1186/s12885-015-2025-z) contains supplementary material, which is available to authorized users. (woofahs.com)
  • 13K, docx)Mean Fluorescence Strength (MFI) of monocyte-derived cells cultured in existence or lack of renal tumor cells (Compact disc105+ CSCs and Compact Firocoxib disc105- TCs). (woofahs.com)
  • Von Hippel-Lindau (VHL) loss is the hallmark event characterizing the clear cell renal cancer subtype (ccRCC). (gencat.cat)
  • abstract = "Background: The current method for cell line authentication is genotyping based on short tandem repeat (STR)-PCR involving coamplification of a panel of STR loci by multiplex PCR and downstream fragment length analysis (FLA), usually performed by capillary electrophoresis. (port.ac.uk)
  • The magnitude, kinetics and phenotype of the circulating tumor-specific CD8 + T cell response were determined. (bmj.com)
  • Dissociation between mature phenotype and impaired transmigration in dendritic cells from heparanase-deficient mice. (southernbiotech.com)
  • The T-cell phenotype accounts for more than 80% of cases, with the remainder of B-cell origin. (medscape.com)
  • Over the years, Rolny and colleagues have demonstrated that reprogramming the pro-tumor phenotype of TAMs into an anti-tumor Page 2(3) phenotype represents a promising anti-cancer strategy. (lu.se)
  • Here, we describe the development of ABBV-011, a novel SEZ6-targeted, calicheamicin-based ADC for the treatment of small cell lung cancer (SCLC). (aacrjournals.org)
  • To this topic, lycopene had been demonstrated to have synergism from the combination of oxaliplatin in a human ovarian cancer cell line ( 20 ), suggesting that the adjuvant property on the anticancer of lycopene. (frontiersin.org)
  • We aimed to evaluate the impact of cancer cell paracrine on mesothelial cell response to different sclerosing agents. (medscimonit.com)
  • However, cancer cells are heterogeneous both within and between patients, forcing the need for individual characterization of the tumor cells. (biomedcentral.com)
  • Photodynamic therapy is a promising approach for cancer treatment that relies on the administration of a photosensitizer followed by tumor illumination. (tcd.ie)
  • Cancer Cell. (nih.gov)
  • Altered cellular metabolism is a hallmark of cancer, and much of the published literature has focused on neoplastic cell-autonomous processes for these adaptations. (elifesciences.org)
  • We demonstrate that exosomes secreted by patient-derived CAFs can strikingly reprogram the metabolic machinery following their uptake by cancer cells. (elifesciences.org)
  • We find that CAF-derived exosomes (CDEs) inhibit mitochondrial oxidative phosphorylation, thereby increasing glycolysis and glutamine-dependent reductive carboxylation in cancer cells. (elifesciences.org)
  • Through 13C-labeled isotope labeling experiments we elucidate that exosomes supply amino acids to nutrient-deprived cancer cells in a mechanism similar to macropinocytosis, albeit without the previously described dependence on oncogenic-Kras signaling. (elifesciences.org)
  • Clinical Correlation of Function and TCR vbeta Diversity of MAGE-C2-Specific CD8(+) T Cell Response in Esophageal Cancer. (amedeo.com)
  • Engineering Cancer Antigen-Specific T Cells to Overcome the Immunosuppressive Effects of TGF-beta. (amedeo.com)
  • The Sympathetic Nervous System Modulates Cancer Vaccine Activity through Monocyte-Derived Cells. (amedeo.com)
  • This study shows that GDF-15 plays an important role in the development of pancreatic cancer and might be required for the development of early pancreatic tumors," says principal investigator Denis Guttridge, PhD, professor of Cancer Biology and Genetics at Ohio State and associate director for basic research. (medicalxpress.com)
  • Guttridge and his colleagues conducted the study using pancreatic-cancer cell lines, cells from patient tumors and an animal model. (medicalxpress.com)
  • Both GDF-15 and NF-kB are overexpressed in patients with pancreatic cancer . (medicalxpress.com)
  • Can a vitamin transform natural killer cells into a cancer therapy? (medicalxpress.com)
  • The aim of our group is to understand the factors regulating programmed cell death in cancer cells. (gla.ac.uk)
  • In contrast, the loss of HOTAIR can inhibit cancer invasion, especially in cells with excessive PRC2 activity. (biomedcentral.com)
  • In other tumor entities the goal of cancer treatment has already moved from palliation to cure in distinct oligometastatic patient subgroups. (springer.com)
  • We are also interested in a compartment of the cell called the nucleolus which has been identified as a good target for anti-cancer agents. (ed.ac.uk)
  • Non-small cell lung cancer (NSCLC) is the leading cancer killer worldwide [ 1 ]. (biomedcentral.com)
  • The objective of this study was to optimize conditions for preparing Boswellea sacra essential oil with the highest biological activity in inducing tumor cell-specific cytotoxicity and suppressing aggressive tumor phenotypes in human breast cancer cells. (biomedcentral.com)
  • Boswellia sacra essential oil-mediated cell viability and death were studied in established human breast cancer cell lines (T47D, MCF7, MDA-MB-231) and an immortalized normal human breast cell line (MCF10-2A). (biomedcentral.com)
  • All three human breast cancer cell lines were sensitive to essential oil treatment with reduced cell viability and elevated cell death, whereas the immortalized normal human breast cell line was more resistant to essential oil treatment. (biomedcentral.com)
  • Suppression of cellular network formation and disruption of spheroid development of breast cancer cells by Boswellia sacra essential oil suggest that the essential oil may be effective for advanced breast cancer. (biomedcentral.com)
  • Cancer stem cells have been found to be particularly susceptible to infection by human cytomegaloviruses. (surgicalneurologyint.com)
  • Introduction: Circulating tumor cells (CTCs) have been studied in breast cancer with the CellSearch® system. (utwente.nl)
  • Although genomic instability, epigenetic abnormality, and gene expression dysregulation are hallmarks of colorectal cancer, these features have not been simultaneously analyzed at single-cell resolution. (pharmaceuticalintelligence.com)
  • The cancer cells' DNA demethylation degrees clearly correlated with the densities of the heterochromatin-associated histone modification H3K9me3 of normal tissue and those of repetitive element long interspersed nuclear element 1. (pharmaceuticalintelligence.com)
  • On the top of the heatmap, the amplification or deletion frequency of each genomic bin (250 kb) of the non-hypermutated CRC samples from the TCGA Project and patient CRC01's cancer cells are shown. (pharmaceuticalintelligence.com)
  • Lung cancer is a very common malignant tumor. (researchsquare.com)
  • Even f low-dose radaton entaled very low cancer rsk, the - most of these results were obtaned n vtro proporton of cancer attrbutable to these sources of and have not been confrmed n vvo, radaton mght be substantal because everybody s - the ntal bophyscal cell damage by onzng exposed to cosmc, terrestral and medcal radaton. (who.int)
  • The cell carrying this abnormality is relatively protected against apoptotic death because of the oncogenic effect of CCND2, leading to re-initiation of cell cycle and genomic instability. (medscape.com)
  • Quantifying the heritability of testicular germ cell tumour using both population-based and genomic approaches. (cdc.gov)
  • Rarely are these tumors found in patients younger than 10 years or older than 60 years. (medscape.com)
  • Other particles may be engulfed by epithelial cells, primarily in the vicinity of the bronchial-alveolar duct junctions, and retained for much longer periods, with gradual removal to lymph nodes. (cdc.gov)
  • Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)
  • General references Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)
  • The molecular mechanisms underlying such resistance have been investigated in a range of tumour types, including the adult brain tumours glioblastoma, yet little is known for paediatric brain tumours. (biomedcentral.com)
  • The investigation of the mechanisms of cell death under the oxidative stress of PDT is of paramount importance to understand how the immune system is activated and, ultimately, to make PDT a more appealing/relevant therapeutic option. (tcd.ie)
  • A possible explanation might be 'tumour dormancy', where a tumour grows very slowly because of a balance between the neoplasia and the immune (and nonimmune) mechanisms of tumour control. (unifi.it)
  • More recently, a number of studies have focused on the procoagulant mechanisms exhibited by tumor cells. (scielo.br)
  • In the present study, we dissected the molecular mechanisms responsible for the procoagulant activity of MV3, a highly aggressive human melanoma cell line. (scielo.br)
  • Simplified illustration of a cell, pointing out some of the important mechanisms of viral oncomodulation. (surgicalneurologyint.com)
  • NF-kB is involved in inflammation and drug resistance mechanisms through the activation of several mediators, including STAT3. (bvsalud.org)
  • Optimizing Flow Cytometric Analysis of Immune Cells in Samples Requiring Cryopreservation from Tumor-Bearing Mice. (amedeo.com)
  • Somatic mutations can reduce or abolish the ability of immune cells to recognize neoantigens on the tumor cells [ 8 ]. (aging-us.com)
  • Furthermore, transgenic mice harboring the viral-encoded large T-antigen (LT-Ag) alone develop tumors of neuroectodermal origin, including malignant peripheral nerve sheath tumors (MPNSTs) and glioblastomas. (cdc.gov)
  • Mice were subsequently challenged with tumor cells, and the tumor protection was monitored. (bmj.com)
  • 0.3% of the total circulating CD8 T cell population fully protects mice against lethal tumor challenge. (bmj.com)
  • 4. Gillan V, Lawrence RA, Devaney E. B cells play a regulatory role in mice infected with the L3 of Brugia pahangi. (southernbiotech.com)
  • SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice. (southernbiotech.com)
  • High-dose chemotherapy with autologous stem cell transplantation is infrequently also used. (sciencedaily.com)
  • Autologous vaccine generated from tumor cells harvested from pleural effusions was administered to patients with advanced NSCLC with the objectives of assessing safety and immune response. (biomedcentral.com)
  • Autologous tumor-specific immune response was seen in two of the three, manifested by IL-5 (1 patient after 3 doses), and IFN-γ, TNF-α, IL-5, IL-10 (after 4 doses in one patient). (biomedcentral.com)
  • Autologous as well as allogeneic CD8 + T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. (oncotarget.com)
  • NSCLC without driver mutations is one of the most heavily mutated of human cancers [ 8 ], thus it is likely that NSCLC cells harbor neoantigens to which the host would not be tolerant, and against which the immune system could mount a strong, destructive immune response. (biomedcentral.com)
  • Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A. (lu.se)
  • Non-ETP subtypes of T-cell lymphoblastic leukemia/lymphoma, in contrast, are associated with activating NOTCH1 mutations in over half of all patients and an additional 10% to 15% of cases have FBXW7 mutations, which also result in increased NOTCH signaling. (medscape.com)
  • Whilst U87MG shared the same dampened p53 activity, upon chemotherapeutic drug treatment in chronic hypoxic conditions, these cells used a different mechanism, independent of the DNA damage pathway. (biomedcentral.com)
  • Up-regulation of leukocyte CXCR4 expression by sulfatide: an L-selectin-dependent pathway on CD4 + T cells. (southernbiotech.com)
  • Finally, we evaluated the implication of the NF-kB pathway in everolimus-resistant Pa-NET cells. (bvsalud.org)
  • The activation of the STAT3 pathway induced by TNFα is mediated by NF-kB p65. (bvsalud.org)
  • In 2002, Bardaro et al reported a second copy of the NEMO gene, deltaNEMO , which is 31.6 kb from exon 10 and contains exons 3-10. (medscape.com)
  • People with CYLD cutaneous syndrome are born with a mutation in one of the two copies of the CYLD gene in each cell. (medlineplus.gov)
  • This mutation prevents the cell from making functional CYLD enzyme from the altered copy of the gene. (medlineplus.gov)
  • For tumors to develop, a second mutation that alters or removes (deletes) the normal copy of the CYLD gene must occur. (medlineplus.gov)
  • When both copies of the CYLD gene are mutated, the cell cannot produce any functional CYLD enzyme. (medlineplus.gov)
  • In people with CYLD cutaneous syndrome, a second CYLD gene mutation typically occurs in multiple cells over an affected person's lifetime. (medlineplus.gov)
  • Ninety percent of the tumor cells had a point mutation in the gene MYD88. (sciencedaily.com)
  • TOP2A (DNA topoisomerase II alpha) gene, mapped to chromosome 17q12-q21, covers approximately 27.5 kb and includes 35 exons, encoding a 170 kDa protein [ 7 ]. (jcancer.org)
  • The survivin gene is 15 KB in length, located at 17q25, and has 4 exons and 3 introns. (researchsquare.com)
  • More than one type of skin tumor often develops, including benign growths called cylindromas, spiradenomas, and trichoepitheliomas. (medlineplus.gov)
  • While the skin tumors associated with CYLD cutaneous syndrome are typically benign, occasionally they may become cancerous (malignant). (medlineplus.gov)
  • Large benign tumors may become ulcers and prone to infections. (medlineplus.gov)
  • In one third of patients the anterior mediastinal mass is an incidental finding of a routine chest radiograph (in most of these cases, a benign tumor is found). (medscape.com)
  • Studies reliant on molecular detection of tumor-associated virus in isolation, however extensive, are inconclusive because association between PyVs and naturally occurring neoplasms varies and because PyV infections are highly prevalent, yet tumor formation is rare ( 3 , 4 , 12 - 14 ). (cdc.gov)
  • Notably, many natural compounds have been found to effectively suppress NF-κB signaling, providing an experimentally validated molecular explanation for their functional outcomes in tumor cells ( 14 ). (spandidos-publications.com)
  • Molecular cell. (gla.ac.uk)
  • Cell migration was detected by wound healing and Transwell assays, while cell invasion was detected by a Matrigel‑coated Transwell method. (spandidos-publications.com)
  • It was observed that tumor cells strongly accelerate plasma coagulation as a result of: i) expression of the blood clotting initiator protein, a tissue factor, as shown by flow cytometry and functional assays (factor Xa formation in the presence of cells and factor VIIa), and ii) direct activation of prothrombin to thrombin by cells, as evidenced by hydrolysis of the synthetic substrate, S-2238, and the natural substrate, fibrinogen. (scielo.br)
  • After TCR identification, we generated HLA-A*02:01/peptide restricted TCR transgenic T cells by retroviral transduction and tested T cell expansion rates as well as A*02:01/peptide recognition and ES killing in ELISpot and xCELLigence assays. (oncotarget.com)
  • TCR transgenic T cells demonstrated HLA-A*02:01/ADRB3 295 mediated ES recognition and killing in ELISpot and xCELLigence assays. (oncotarget.com)
  • Finally, restoration of EGR1 or PTEN expression is sufficient to induce synovial sarcoma cell death. (nature.com)
  • Evidence that PyVs induce tumors after natural infection is accumulating but more controversial. (cdc.gov)
  • These tumors can be found anywhere on the midline, particularly the retroperitoneum, the anterior mediastinum, the sacrococcyx, and the pineal gland. (medscape.com)
  • Activation of the transcription factor nuclear factor KB (NF-KB) requires the NEMO protein. (medscape.com)
  • EVs produced from Compact Firocoxib disc105+ CSCs and in much less extent, those produced from Compact disc105- TCs maintained the capability to impair monocyte maturation and T cell activation. (woofahs.com)
  • Adoptive T Cell Therapy with IL-12-Preconditioned Low-Avidity T Cells Prevents Exhaustion and Results in Enhanced T Cell Activation, Enhanced Tumor Clearance, and Decreased Risk for Autoimmunity. (amedeo.com)
  • In contrast, prothrombin activation was not observed when cells were previously incubated with DEGR-factor Xa, an inactive derivative of the enzyme. (scielo.br)
  • Role of Fc gamma receptors in triggering host cell activation and cytokine release by Borrelia burgdorferi. (southernbiotech.com)
  • Dual role of CD38 in microglial activation and activation-induced cell death. (southernbiotech.com)
  • Further, lung fibroblasts were cultured with and without cell supernatants from previously established cell cultures for 24 h. (medscimonit.com)
  • The exposure of lung fibroblasts to supernatant from mesothelial cell (with or without adenocarcinoma) did not affect collagen secretion. (medscimonit.com)
  • The concentration of survivin in diseased tissue and miR-29a and IGRAs in serum in 25 patients with non-small-cell lung carcinoma (NSCLC) complicated by active pulmonary tuberculosis (APT) and 32 patients with NSCLC and 30 patients with APT were measured. (researchsquare.com)
  • For these short fibers, which can be fully engulfed by lung cells and do not dissolve in airway fluids in less than a few weeks, their clearance will be similar to other mineral and vitreous particles. (cdc.gov)
  • However, low dose inoculations via the IP or SC route or IN vaccination elicited vaccine-induced CD8 + T cell responses that did not reach protective thresholds for tumor protection. (bmj.com)
  • This is called tumour hypoxia and leads to resistance to radiotherapy and chemotherapy. (biomedcentral.com)
  • We aimed to elucidate the impact of hypoxia on the sensitivity of MB cells to chemo- and radiotherapy. (biomedcentral.com)
  • This acquired resistance upon chronic hypoxia was present but less pronounced in MEB-Med8A cells. (biomedcentral.com)
  • Together our results demonstrate a new mechanism explaining hypoxia-induced resistance involving the alteration of the response to DSB in D283-MED cells, but also highlight the cell type to cell type diversity and the necessity to take into account the differing tumour genetic make-up when considering re-sensitisation therapeutic protocols. (biomedcentral.com)
  • A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells. (amedeo.com)
  • Midline fast-growing tumors (eg, of the mediastinum, retroperitoneum) occur in young males. (medscape.com)
  • on monocyte-derived cells compared with DCs (CTL DC) (Fig.?4a). (woofahs.com)
  • on monocyte-derived cells (Fig.?4a). (woofahs.com)
  • 14K, docx)Mean Fluorescence Strength (MFI) of monocyte-derived cells activated with or without EVs shed by Compact disc105+ CSCs and Compact disc105- TCs. (woofahs.com)
  • Tumor-derived autophagosome vaccines (DRibbles) have the potential to broaden immune response to poorly immunogenic tumors. (biomedcentral.com)