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  • inhibit
  • We have investigated eosinophils as potential anti-cancer effector cells, and have reported the ability of their toxic granular proteins (MBP, EPO, ECP, EDN) to inhibit prostate tumor cell growth in vitro . (scirp.org)
  • Moreover, a recent study with various malignant tumor cells showed that celecoxib could inhibit the growth of these cells, even though some of these cancer cells didn't even contain COX-2. (wikipedia.org)
  • However, when the ability of all these compounds to kill tumor cells in cell culture was investigated, it turned out that the antitumor potency did not at all depend on whether or not the respective compound could inhibit COX-2, showing that inhibition of COX-2 was not required for the anticancer effects. (wikipedia.org)
  • One of these compounds, 2,5-dimethyl-celecoxib, which entirely lacks the ability to inhibit COX-2, actually turned out to display stronger anticancer activity than celecoxib itself and this anticancer effect could also be verified in highly drug-resistant tumor cells and in various animal tumor models. (wikipedia.org)
  • induce
  • Mechanistic studies indicated that LD/LP tumor cells induced aggregation of homologous platelets, whereas HD/HP B16a cells failed to induce significant platelet aggregation. (rti.org)
  • Panobinostat, along with other HDAC inhibitors, is also being studied for potential to induce virus HIV-1 expression in latently infected cells and disrupt latency. (wikipedia.org)
  • gene
  • Hypoxia induced ATF4 and the HIF1alpha target gene apelin in CTCs, but not in parental cells. (nih.gov)
  • D) Expression of ATF4 and its target gene ASNS in CTCs, compared with parental MDA-MB-231 cells. (nih.gov)
  • However, it is unclear how these microenvironmental conditions interact to promote neovascularization, due in part to a lack of comprehensive, unbiased data sets describing tumor cell gene expression as a function of oxygen levels within three-dimensional (3D) culture. (sigmaaldrich.com)
  • Microarray gene expression analysis of tumor cells cultured in 2D versus 3D under ambient or hypoxic conditions revealed striking interdependence between culture dimensionality and hypoxia response, which was mediated in part by pro-inflammatory signaling pathways. (sigmaaldrich.com)
  • This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. (wikipedia.org)
  • However, some tumor cells are able to repair this type of DNA damage, and therefore diminish the therapeutic efficacy of temozolomide, by expressing a protein O6-alkylguanine DNA alkyltransferase (AGT) encoded in humans by the O-6-methylguanine-DNA methyltransferase (MGMT) gene. (wikipedia.org)
  • In some tumors, epigenetic silencing of the MGMT gene prevents the synthesis of this enzyme, and as a consequence such tumors are more sensitive to killing by temozolomide. (wikipedia.org)
  • The majority of research has focused on the Wnt/β-catenin pathway (also known as the "canonical" Wnt pathway), which manages cell fate determination by regulating gene expression. (wikipedia.org)
  • To carry out gene expression, a cell must control the coiling and uncoiling of DNA around histones. (wikipedia.org)
  • vivo
  • Prolonged culture resulted in a 10-fold decrease in the incidence of B16a lung colonies, whereas passage in vivo for 150 days did not affect lung colony formation by tumor cells isolated from enzymatic dispersates by centrifugal elutriation. (rti.org)
  • Cultured TECs maintain distinct biological differences from NECs as in vivo. (nih.gov)
  • A 2015 study suggested Panobinostat was effective in preventing diffuse intrinsic pontine glioma cell growth in vitro and in vivo, identifying it as a potential drug candidate. (wikipedia.org)
  • genes
  • E and F) Differences between CTCs and parental MDA-MB-231 cells with respect to induction of HIF1α target genes. (nih.gov)
  • In T-VEC, deletions of wild-type γ 34.5 and α 47 viral genes promote targeting tumor cells over nonneoplastic cells and enhance the body's natural antitumor response ( 7 ). (asm.org)
  • tissue
  • Cells grown in vitro from neoplastic tissue. (jove.com)
  • Furthermore, these results highlight the importance of pathologically relevant tissue culture models to study the complex physical and chemical processes by which the cancer microenvironment mediates new vessel formation. (sigmaaldrich.com)
  • Lung colony formation by elutriated B16a cells (i.e., cells freshly isolated from tumor tissue) was consistently inhibited by CGS14854, whereas inhibition of lung colony formation by cultured B16a cells was dependent upon culture conditions. (rti.org)
  • However, it is challenging to isolate and culture large numbers of pure ECs from tumor tissue since the percentage of ECs is only about 1-2% and tumor cells and fibroblasts easily overgrow them. (nih.gov)
  • The biological effects of the omega-6 fatty acids are largely produced during and after physical activity for the purpose of promoting growth and during the inflammatory cascade to halt cell damage and promote cell repair by their conversion to omega-6 eicosanoids that bind to diverse receptors found in every tissue of the body. (wikipedia.org)
  • Mesenchymal cells typically leave the epithelial tissue as a consequence of changes in cell adhesive and contractile properties. (wikipedia.org)
  • Expression levels of several targets of the Wnt signaling pathways are increased in tumor tissue compared with normal, and the expression of SFRP1 is lost in patient tumor samples. (wikipedia.org)
  • While trying to grow common cold viruses, he and his colleague Dr. Wallace Rowe first tried to use adenoid and tonsil tissue, before using a culture based on tumor cells. (wikipedia.org)
  • After losing energy as they penetrate tissue, the neutrons are absorbed by the capture agent, which subsequently emits high-energy charged particles that can selectively kill tumor cells that have taken up sufficient quantities of 10B (Fig.1). (wikipedia.org)
  • malignant
  • As of August 2012[update], it is being tested against Hodgkin's Lymphoma, cutaneous T cell lymphoma (CTCL) and other types of malignant disease in Phase III clinical trials, against myelodysplastic syndromes, breast cancer and prostate cancer in Phase II trials, and against chronic myelomonocytic leukemia (CMML) in a Phase I trial. (wikipedia.org)
  • mediates
  • The activation of P2 receptors induces intracellular calcium signalling which mediates the fibrogenic function of activated stellate cells. (wikipedia.org)
  • aggressive
  • We suggest this is common phenomenon in head and neck squamous cell carcinoma (HNSCC) cell lines and other aggressive tumour cell lines. (biomedsearch.com)
  • The objective of this study was to optimize conditions for preparing Boswellea sacra essential oil with the highest biological activity in inducing tumor cell-specific cytotoxicity and suppressing aggressive tumor phenotypes in human breast cancer cells. (biomedcentral.com)
  • induces
  • Similar to our previous observations in human bladder cancer cells, Boswellia sacra essential oil induces breast cancer cell-specific cytotoxicity. (biomedcentral.com)
  • laboratory
  • RESULTS: There were observable differences in growth of the cells on laboratory plastic and collagen matrix. (biomedsearch.com)
  • Briefly, granular proteins were differentially extracted from GRC.014.22 and GRC.014.24, eosinophilic cell lines established in our laboratory from a patient with moderate asthma. (scirp.org)
  • Protein extracts were fractionated on Sephadex G-50 columns, and prostate tumor cell lines DU-145, LNCaP, PC-3, and HPC8L (established in our laboratory from a tumor resected from an African American patient) were treated with MBP extracts from the pooled third peaks. (scirp.org)
  • but studies in laboratory mice have shown that nelfinavir is able to suppress the growth of tumors in these animals, which represents a promising lead towards testing this drug in humans as well. (wikipedia.org)
  • After culturing and isolating the organism in laboratory mice, the pathogen they named Rickettsia akari was identified as the ultimate cause of the disease now called rickettsialpox. (wikipedia.org)
  • protein
  • Panobinostat has also been found to significantly increase in vitro the survival of motor neuron (SMN) protein levels in cells of patients suffering from spinal muscular atrophy. (wikipedia.org)
  • human
  • We have demonstrated that these basement membrane molecules were produced by ACC2 and ACC3 cells, established independently from human salivary adenoid cystic carcinomas. (nii.ac.jp)
  • We have also shown that adenoid cystic carcinoma dells attach, spread, and grow rapidly on matrices conta … More ining basement membrane molecules, using ACC3 cells of human adenoid cystic carcinoma origin. (nii.ac.jp)
  • Boswellia sacra essential oil-mediated cell viability and death were studied in established human breast cancer cell lines (T47D, MCF7, MDA-MB-231) and an immortalized normal human breast cell line (MCF10-2A). (biomedcentral.com)
  • All three human breast cancer cell lines were sensitive to essential oil treatment with reduced cell viability and elevated cell death, whereas the immortalized normal human breast cell line was more resistant to essential oil treatment. (biomedcentral.com)
  • To better understand the interaction of HSV-1 with neoplastic cells, we inoculated three-dimensional (3D) cultures of human uveal melanoma cells with HSV-1. (asm.org)
  • determined that Saos-2 cells "possess several osteoblastic features and could be useful as a permanent line of human osteoblast-like cells and as a source of bone-related molecules. (wikipedia.org)
  • It has been shown that the deregulation of this critical developmental pathway occurs in several human tumor entities. (wikipedia.org)
  • embryonic development
  • As of early 2016, there are three families belonging to the MACPF superfamily: 1.C.12 - The Thiol-activated Cholesterol-dependent Cytolysin (CDC) Family 1.C.39 - The Membrane Attack Complex/Perforin (MACPF) Family 1.C.97 - The Pleurotolysin Pore-forming (Pleurotolysin) Family Proteins containing MACPF domains play key roles in vertebrate immunity, embryonic development, and neural-cell migration. (wikipedia.org)
  • The process controls the organized spatial distribution of cells during the embryonic development of an organism. (wikipedia.org)
  • During embryonic development, cells are restricted to different layers due to differential affinities. (wikipedia.org)
  • blood vessels
  • We have proposed that their frequent invasion of peripheral nerves, blood vessels, and skeletal muscles can be interpreted to mean that adenoid cystic carcinoma cells have an affinity for basement membranes. (nii.ac.jp)
  • collagen
  • In this study, we successfully cultured ACC cells in collagen gel and examined the process of pseudocyst formation in tumor cell colonies. (nii.ac.jp)
  • In the collagen gel culture, the cells formed spherical colonies and the tumor cell nests contained vacuolar structures that were immunopositive for heparan sulfate proteoglycan, type III collagen and type IV collagen, and fibronectin. (nii.ac.jp)
  • The results indicate that our collagen gel culture system provides physiological conditions for ACC2 cells to secrete particular extracelluar matrix molecules and form pseudocystic spaces. (nii.ac.jp)
  • Publications] Munakata, R.: 'Pseudocyst tormation by adenoid cystic carcinoma cells collagen gel culture and in SCID mice' J Oral Pathol Med. (nii.ac.jp)
  • Furthermore
  • Furthermore, our findings raise the possibility that HSV-1 infection of neoplastic cells during natural infections or vaccinations may promote the growth of tumors. (asm.org)
  • Furthermore, cells can sort based upon differences in adhesion between the cells, so even two populations of cells with different levels of the same adhesion molecule can sort out. (wikipedia.org)
  • determinants
  • The oligosaccharide groups on gangliosides extend well beyond the surfaces of the cell membranes, and act as distinguishing surface markers that can serve as specific determinants in cellular recognition and cell-to-cell communication. (wikipedia.org)
  • breast
  • Suppression of cellular network formation and disruption of spheroid development of breast cancer cells by Boswellia sacra essential oil suggest that the essential oil may be effective for advanced breast cancer. (biomedcentral.com)
  • partially reversing the morphological changes characteristic of breast cancer cells. (wikipedia.org)
  • molecules
  • The pseudocysts are surrounded by tumor cells and are filled with extracellular matrix components such as basement membrane molecules. (nii.ac.jp)
  • Publications] Cheng, J.: 'Biosynthesis of basement membrane molecules by salivary adenoid cystic carcinoma cells : an immunofluorescence and confocal microscopic study. (nii.ac.jp)
  • An important class of molecules involved in morphogenesis are transcription factor proteins that determine the fate of cells by interacting with DNA. (wikipedia.org)
  • At the end of this cascade are classes of molecules that control cellular behaviors such as cell migration, or, more generally, their properties, such as cell adhesion or cell contractility. (wikipedia.org)
  • One of the ways this can occur is when cells share the same cell-to-cell adhesion molecules. (wikipedia.org)
  • For instance, homotypic cell adhesion can maintain boundaries between groups of cells that have different adhesion molecules. (wikipedia.org)
  • Gangliosides are present and concentrated on cell surfaces, with the two hydrocarbon chains of the ceramide moiety embedded in the plasma membrane and the oligosaccharides located on the extracellular surface, where they present points of recognition for extracellular molecules or surfaces of neighboring cells. (wikipedia.org)
  • proteins
  • Basic proteins and polyamino acids are taken up by mammalian cells at rates up to 3000 times greater than serum albumin. (sciencemag.org)
  • The MACPF domain is structurally similar to pore-forming cholesterol-dependent cytolysins from gram-positive bacteria, suggesting that MACPF proteins create pores and disrupt cell membranes similar to cytolysin. (wikipedia.org)
  • For example, during gastrulation, clumps of stem cells switch off their cell-to-cell adhesion, become migratory, and take up new positions within an embryo where they again activate specific cell adhesion proteins and form new tissues and organs. (wikipedia.org)
  • Stellate cells express smoothened (Smo) and patched-1 (Ptch1) proteins, which are significant features of the hedgehog receptor system. (wikipedia.org)
  • isolation
  • The publication of two seminal research papers in 1998 outlining the isolation of these cells provided an in vitro method by which researchers may characterise PaSCs in both health and pathology. (wikipedia.org)
  • freshly
  • Ai) Freshly captured CTCs are cells with attached magnetic beads as indicated by white arrows. (nih.gov)
  • processes
  • IMC is sensitive enough to detect and follow either slow processes (reactions proceeding at a few % per year) in a few grams of material, or processes which generate minuscule amounts of heat (e.g. metabolism of a few thousand living cells). (wikipedia.org)
  • cancer
  • IMPORTANCE Cancer cells are exposed to HSV-1 during oncolytic virotherapy with the intention of killing tumor cells. (asm.org)
  • February 23, 1914 - August 26, 1998), was an American physician and virologist whose research into viruses, their causes and treatment that led to his breakthrough insights into the connections between viruses and cancer, leading to new treatments, as well as his hypothesized oncogene, which was discovered to be a trigger for normal cells turning cancerous. (wikipedia.org)
  • Each component in itself is non-tumoricidal, but when combined together they are highly lethal to cancer cells. (wikipedia.org)
  • Stem
  • Stem cell antigen-1 was up-regulated in all four TECs, suggesting that they have a kind of stemness. (nih.gov)
  • gland
  • PaSCs compose 4-7% of the total cell mass in the gland Stellate cells derive their name from their star shape and are located in other organs such as the kidney and lungs. (wikipedia.org)
  • dependent upon
  • Oncolytic HSV-1 therapy is dependent upon virus replication in tumor cells and is augmented by host antiviral and infection-induced antitumor immune responses ( 1 , 3 - 6 ). (asm.org)
  • The success of BNCT is dependent upon the selective delivery of sufficient amounts of 10B to the tumor with only small amounts localized in the surrounding normal tissues. (wikipedia.org)
  • colonies
  • Cultured B16a cells maintained at low density (LD) and harvested at low passage (LP) formed significantly more lung colonies than B16a cells harvested at high densities (HD) or high passage (HP). (rti.org)
  • Over-confluent tumor cells produced even lower number of lung colonies. (rti.org)
  • growth
  • These findings suggest that although HSV-1 oncolytic virotherapy may cause extensive tumor cell killing, it may also be associated with the unintended promotion of the growth of some tumor cells. (asm.org)
  • Our observations reported here suggest that potential dangers of HSV-1 oncolytic therapy include promotion of growth of some tumor cells. (asm.org)
  • In biological specimens containing a growth medium, appearance over time of a detectable and rising heat flow signal is a simple general indicator of the presence of some type of replicating cells. (wikipedia.org)
  • Growth in culture and anchorage-independent growth were inhibited in SFRP1-expressing UMRC3 cells. (wikipedia.org)
  • differences
  • The differences in lung colony formation between LD, HD and elutriated B16a cells were not due to differential cell-cycle distribution. (rti.org)
  • inhibitor
  • We first investigated the effects of cell source and culture conditions on lung colony formation by i.v. injected B16a (B16 amelanotic melanoma) cells and inhibition of tumor colony formation by the thromboxane A2 synthase inhibitor, CGS14854. (rti.org)
  • INH1, a thiazolyl benzamide compound, is a cell-permeable Hec1/Nek2 mitotic pathway inhibitor I. INH1 controls the biological activity of Hec1/Nek2 mitotic pathway. (wikipedia.org)
  • phenotype
  • In addition, there has been concern that isolated TECs may lose their special phenotype once they are dissociated from tumor cells. (nih.gov)
  • tissues
  • In addition, given the risks of using animal serum for tissue engineering, autologous blood may gain favor as a source of growth factors and serum supplements needed for stimulating cells to engineer intervertebral disc tissues. (blogspot.com)
  • Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver. (semanticscholar.org)
  • Combining two-photon microscopy with fluorescent tracers, we successfully visualized the engrafted tissues at the single cell level in live mice over several months. (jove.com)
  • Imaging using confocal/two-photon hybrid microscopy enables simultaneous high resolution assessment of uniquely marked cells and their progeny in conjunction with structural components of the tissues. (jove.com)
  • Volumetric analyses over large areas reveal that spectrally coded HSPC-derived cells can be detected non-invasively in various intact tissues, including the bone marrow (BM), for extensive periods of time following transplantation. (jove.com)
  • Ipilimumab patients expressed increased ICOS+ T cells in tumor tissues and blood. (wikipedia.org)
  • This action of androgens is supported by a hormone from Sertoli cells, Müllerian inhibitory hormone (MIH), which prevents the embryonic Müllerian ducts from developing into fallopian tubes and other female reproductive tract tissues in male embryos. (wikipedia.org)
  • murine
  • We developed and validated a fluorescent marking methodology for clonal tracking of hematopoietic stem and progenitor cells (HSPCs) with high spatial and temporal resolution to study in vivo hematopoiesis using the murine bone marrow transplant experimental model. (jove.com)
  • Protective
  • DNA vaccination is a technique for protecting against disease by injection with genetically engineered DNA so cells directly produce an antigen, producing a protective immunological response. (wikipedia.org)
  • senescent cells
  • Although senescent cells can no longer replicate, they remain metabolically active and commonly adopt an immunogenic phenotype consisting of a pro-inflammatory secretome, the up-regulation of immune ligands, a pro-survival response, promiscuous gene expression (pGE) and stain positive for senescence-associated β-galactosidase activity. (wikipedia.org)
  • The nucleus of senescent cells is characterized by senescence-associated heterochromatin foci (SAHF) and DNA segments with chromatin alterations reinforcing senescence (DNA-SCARS). (wikipedia.org)
  • The experimental elimination of senescent cells from transgenic progeroid mice and non-progeroid, naturally-aged mice led to greater resistance against aging-associated diseases. (wikipedia.org)
  • The word "post-mitotic" is sometimes used to refer to both quiescent and senescent cells. (wikipedia.org)
  • germ cells
  • During spermatogenesis in mammals and in Drosophila melanogaster, male germ cells develop in a series of essential developmental processes. (jove.com)
  • In addition, post-meiotic germ cells undergo a dramatic morphological reshaping process as well as a global epigenetic reconfiguration of the germ line chromatin-the histone-to-protamine switch. (jove.com)
  • At about week 6, epithelial sex cords develop within the forming testes and incorporate the germ cells as they migrate into the gonads. (wikipedia.org)
  • bacteria
  • Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites, and also tumor cells. (wikipedia.org)
  • In bacteria, which lack a cell nucleus, the cell cycle is divided into the B, C, and D periods. (wikipedia.org)
  • They are found in fermentation broths and yeast cultures and this subunit is often found alone or embedded in larger more complex architectures in a variety of natural products isolated from fungi, bacteria, plants, and mammals, and their core structure occurs in several drugs. (wikipedia.org)
  • neurons
  • Non-proliferative (non-dividing) cells in multicellular eukaryotes generally enter the quiescent G0 state from G1 and may remain quiescent for long periods of time, possibly indefinitely (as is often the case for neurons). (wikipedia.org)
  • mice
  • Similarly, CD4+ T cells purified from ICOS-/- mice immunized with the protein keyhole limpet hemocyanin (KLH) in alum or complete Freund's Adjuvant have attenuated IL-4 secretion, but similar IFN-g and IL-5 secretion when recalled with KLH. (wikipedia.org)
  • After culturing and isolating the organism in laboratory mice, the pathogen they named Rickettsia akari was identified as the ultimate cause of the disease now called rickettsialpox. (wikipedia.org)
  • indicate
  • citation needed] In pathology laboratories, India ink is applied to surgically removed tissue specimens to maintain orientation and indicate tumor resection margins. (wikipedia.org)
  • Components
  • Components and strategies Cell lifestyle MCF-7 cells had been grown up in DMEM moderate filled with 10% fetal leg serum and 1% penicillin/streptomycin serum as defined (9). (cancercurehere.com)
  • beneficial
  • Administration of Type I IFN has been shown experimentally to inhibit tumor growth in animals, but the beneficial action in human tumors has not been widely documented. (wikipedia.org)
  • Human
  • A minor population of nonepithelial cells appear between the tubules by week 8 of human fetal development. (wikipedia.org)
  • These range from the hepatoxic brevianamide F (cyclo(L-Trp-L-Pro)) to the annulated tremorogenic verruculogen and the spiro-annulated spirotryprostatin B which represent a promising class of antimitotic arrest agents, to the structurally complex (+)-stephacidin A, a bridged 2,5-diketopiperazine that possess a unique bicyclo[2.2.iazaoctane core ring system and is active against the human colon HCT-116 cell line. (wikipedia.org)
  • nucleus
  • The response to platelet-rich plasma was greater in the case of anulus fibrosus cells than of nucleus pulposus cells. (blogspot.com)
  • Interphase is a series of changes that takes place in a newly formed cell and its nucleus, before it becomes capable of division again. (wikipedia.org)
  • secretion
  • Compared to wild-type naïve T cells, ICOS-/- T cells activated with plate-bound anti-CD3 have reduced proliferation and IL-2 secretion. (wikipedia.org)
  • In terms of Th1 and Th2 cytokine secretion, ICOS-/- CD4+ T cell activated in vitro reduced IL-4 secretion, while maintaining similar IFN-g secretion. (wikipedia.org)
  • represents
  • Additionally, our outcomes also claim that TRPC3 shows up as a fresh mediator of breasts cancer tumor cell migration/invasion and represents a potential focus on for a fresh course of anticancer agent. (cancercurehere.com)
  • As such, cellular senescence represents a change in "cell state" rather than a cell becoming "aged" as the name confusingly suggests. (wikipedia.org)
  • isolate
  • Thus, protocols to isolate and culture individual organs of interest are essential to provide a method of both visualizing changes in development and allowing novel treatment strategies. (jove.com)
  • This microbe still has yet to be classified based on genomic sequencing or 16S rRNA because it cannot be sustained long enough outside its natural environment to isolate a pure culture. (wikipedia.org)
  • cancerous
  • For a very long time, it has been proposed that mitochondrial dysfunction may predispose some cells-for example, dividing cells-to become cancerous. (pvlsi.org)
  • February 23, 1914 - August 26, 1998), was an American physician and virologist whose research into viruses, their causes and treatment that led to his breakthrough insights into the connections between viruses and cancer, leading to new treatments, as well as his hypothesized oncogene, which was discovered to be a trigger for normal cells turning cancerous. (wikipedia.org)
  • serum
  • HAP1 cells are grown in Iscove's Modified Dulbecco's Medium (IMDM) in the presence of 10% fetal calf serum and penicillin/ streptomycin. (horizondiscovery.com)
  • Cellular
  • Cellular senescence is the phenomenon by which normal diploid cells cease to divide. (wikipedia.org)
  • Consistent with this, telomerase-immortalised cells continued to age (according to the epigenetic clock) without having been treated with any senescence inducers or DNA-damaging agents, re-affirming the independence of the process of epigenetic ageing from telomeres, cellular senescence, and the DNA damage response pathway. (wikipedia.org)
  • Testis
  • He has performed and published research in men's reproductive health issues including genetic infertility, ejaculatory duct obstruction, immunologic infertility, quality of life issues with infertility, testis cancer and stem cell science, and has developed several techniques for evaluating and treating male infertility. (wikipedia.org)
  • activity
  • Previously it was called resting stage because there is no apparent activity related to cell division.Typically interphase lasts for at least 90% of the total time required for the cell cycle. (wikipedia.org)
  • They are of particular research interest because many of them have been reported to show anti-tumour activity in cell culture. (wikipedia.org)
  • blood
  • Hodgkin's lymphoma (HL) is a type of lymphoma, which is generally believed to result from white blood cells of the lymphocyte kind. (wikipedia.org)
  • divisions
  • Although the various stages of interphase are not usually morphologically distinguishable, each phase of the cell cycle has a distinct set of specialized biochemical processes that prepare the cell for initiation of cell divisions. (wikipedia.org)
  • Kills
  • MAJOR CANCER BREAKTHROUGH: Scientists Find Plant That Kills 98% Of Cancer Cells In Just 16 Hours! (unews.top)
  • genome
  • Further to this HAP1 wild-type cells have been extensively characterized by whole genome sequencing and transcriptome analysis . (horizondiscovery.com)
  • cytoplasm
  • As an epibiont, Vampirococcus attaches to the cell surface of their prey and "sucks" out the cytoplasm using a specialized cytoplasmic bridge. (wikipedia.org)
  • During the final stage, cytokinesis, the chromosomes and cytoplasm separate into two new daughter cells. (wikipedia.org)
  • M phase is itself composed of two tightly coupled processes: karyokinesis, in which the cell's chromosomes are divided, and cytokinesis, in which the cell's cytoplasm divides forming two daughter cells. (wikipedia.org)
  • prepare
  • However, the infected cell can prepare neighboring cells against a potential infection by the virus by releasing interferons. (wikipedia.org)
  • Achong's role in the discovery of EBV was to prepare and examine cultured cells prepared from Burkitt's lymphoma samples by electron microscopy. (wikipedia.org)
  • found
  • In agreement with this hypothesis, we have found that palmitate inhibits adiponectin production by adipocytes in a cell-autonomous fashion. (pubmedcentralcanada.ca)
  • response
  • The failure of β-cells to appropriately secrete insulin in response to glucose results in type 2 diabetes, which presents us with one of the biggest health challenges of this century. (pvlsi.org)
  • addition
  • In addition, if pustules are present, cultures are taken to identify which microbes, if any, may be contributing to the inflammation. (wikipedia.org)
  • Phase
  • The cell cycle consists of four distinct phases: G1 phase, S phase (synthesis), G2 phase (collectively known as interphase) and M phase (mitosis). (wikipedia.org)
  • Cells that have temporarily or reversibly stopped dividing are said to have entered a state of quiescence called G0 phase. (wikipedia.org)
  • G0 is a resting phase where the cell has left the cycle and has stopped dividing. (wikipedia.org)
  • The cell cycle starts with this phase. (wikipedia.org)
  • During this phase, the biosynthetic activities of the cell, which are considerably slowed down during M phase, resume at a high rate. (wikipedia.org)
  • In G1 phase, a cell has three options. (wikipedia.org)
  • high
  • Use of 5-fluorodeoxycytidine and tetrahydrouridine to exploit high levels of deoxycytidylate deaminase in tumors to achieve DNA- and target-directed therapies. (semanticscholar.org)