Tumor cells cells in vivo antigen of tumor. Medical search. Frequent questions

Resident memory CD8 + T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive immunity against pathogens. (lifeboat.com)
However, the specific contribution of Trm cells to anti-tumor immunity is incompletely understood. (lifeboat.com)
Studies to antigen uptake, processing and presentation to T cells, the biology of dendritic cells and the regulation of immunity are aimed to raise our understanding of the immune reactions to tumor cells and improve immunotherapy of cancer. (universiteitleiden.nl)
Dijke, P. ten & Cruz, L.J. (2023), Enhancing anti-tumor immunity through liposomal oxaliplatin and localized immunotherapy via STING activation, Journal of Controlled Release 357: 531-544. (universiteitleiden.nl)
The aim of adoptive T-cell therapy of cancer is to selectively confer immunity against tumor cells. (haematologica.org)
It induces macrophage mediated phagocytosis of tumor cells, and boosts T cell dependent anti-tumor immunity in the tumor microenvironment. (aap.com.au)
The aim of this thesis work is to interrogate the pro- and anti- tumorigenic roles myeloid cells play in primary and metastatic disease, and how these myeloid populations interact with cells of the adaptive immune system to influence anti-tumor immunity. (ubc.ca)
In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
However, this finding has triggered further interest in utilising tumour-specific MHC-II to harness sustained anti-tumour immunity through the activation of CD4 + T helper cells. (portlandpress.com)
Thus, their reactivation represents an attractive way to unleash anti-tumour immunity. (portlandpress.com)
Isolated B cells also imparted T cells with the CpG-associated phenotype and improved tumor immunity without the aid of additional antigen-presenting cells or other immune cells in the culture. (bmj.com)
This project will aim to test a cancer immunotherapy approach based on in-vivo dendritic cell reprogramming of tumor cells to reinstate anti-tumor immunity. (lu.se)

Epstein-Barr virus (EBV) infection of B lymphocytes is near universal in humans and stimulates high levels of EBV-specific helper and cytotoxic T cells, which persist indefinitely. (nih.gov)
Preclinical models predict that blockade of the coinhibitory molecule cytotoxic T lymphocyte-associated antigen 4 (CTLA4) on lymphocytes results in the release of a cell cycle inhibitory checkpoint, allowing lymphocyte proliferation, tumor targeting, and regression. (snmjournals.org)
Despite occasional cases of expansion of melanoma-specific T cells ( 14 , 15 ), the bulk of the data suggest that there is no detectable expansion of tumor antigen-specific lymphocytes, in particular when focusing on CD8+ T-cell responses. (snmjournals.org)
The most consistent effects in peripheral blood cells after administering anti-CTLA4 antibodies have been limited to marginal increases in the surface expression of nonspecific activation markers predominantly on CD4+ T lymphocytes ( 16 - 18 ). (snmjournals.org)
In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
Although human CD20 has previously been described as functional selection marker and suicide gene after retroviral transfer to T lymphocytes, 9 , 10 the specificities of these T cells were unknown, and therefore a potential effect of CD20 on antigen-specific T-cell functions could not be investigated. (haematologica.org)
Chromosomal aberrations (hypo- and hyperdiploidy, deletions, breaks, and gaps) in peripheral lymphocytes and bone marrow cells are the predominant effects seen in humans. (cdc.gov)
The introduction of genes that code for tumor-specific receptors into T lymphocytes, which are cells of the immune system that mediate tumor elimination, was a novel approach to cancer therapy. (acgtfoundation.org)
As shown by multiplex tissue immunofluorescence and intravital microscopy, combined immunotherapy treatments enhance T cell infiltration and the intratumoral performance of T lymphocytes. (unav.edu)
MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)
Methods In this study we investigated how tumor-specific murine CD8 + T cells and human tumor infiltrating lymphocytes (TILs) are impacted when expanded ex vivo with the TLR9 agonist CpG. (bmj.com)
Immunotherapy based on the adoptive transfer of ex vivo expanded and activated autologous tumor-reactive lymphocytes can mediate tumor regression in cancer patients. (unimedizin-mainz.de)
Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)

Interestingly, these tumors exhibited characteristics of transdifferentiation and acquired expression of histiocytic/dendritic cell markers. (jci.org)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
Transcriptional profiling of the tumor microenvironment (TME) revealed that ATG-101 reversed T cell exhaustion, increased T cell cytotoxicity, and reduced tolerogenic dendritic cells (DCs). (aap.com.au)
This was accompanied by fewer tumor-infiltrating CD8 + T cells, and STZ-mice had fewer tumor-infiltrating CD11c + dendritic cells (DCs) than normoglycemic mice. (nature.com)
The secretion of Hsp70 from the ovarian cancer cells will allow the Hsp70-associated antigenic peptide to be concentrated and targeted to dendritic cells (DCs) with subsequent DC activation. (acgtfoundation.org)
Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
Experience in dendritic cell biology and antigen presentation mechanisms is a merit, T cell biology is also attractive. (lu.se)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

Primary T cells expressing chimeric receptors specific for tumor or viral antigens have considerable therapeutic potential. (nih.gov)
Unfortunately, their clinical value is limited by their rapid loss of function and failure to expand in vivo, presumably due to the lack of costimulator molecules on tumor cells and the inherent limitations of signaling exclusively through the chimeric receptor. (nih.gov)
We now report that EBV-specific (but not primary) T cells transduced with tumor-specific chimeric receptor genes can be expanded and maintained long-term in the presence of EBV-infected B cells. (nih.gov)
They recognize EBV-infected targets through their conventional T-cell receptor and tumor targets through their chimeric receptors. (nih.gov)
EBV-specific T cells expressing chimeric antitumor receptors may represent a new source of effector cells that would persist and function long-term after their transfer to cancer patients. (nih.gov)
Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
The adoptive cellular immunotherapy with chimeric antigen receptor (CAR) immune cells, which involves modifying a patient's immune cells ex vivo with CARs that can recognize target antigens on tumour cells, is a promising approach. (academics.com)
Chimeric antigen receptors (CAR)-engineered T cells have demonstrated remarkable efficacy in patients with B-cell malignancies. (unimedizin-mainz.de)

Adoptive cell therapy using engineered T-cell receptors (TCRs) targeting cancer-testis antigens, such as Melanoma-associated antigen 3 (MAGE-A3), is a potential approach for the treatment of NSCLC. (thno.org)
In this respect, not only known proteins but also non-coding genetic regions of cells are studied as sources of peptides that can be presented by HLA molecules at the surface of tumor cells and be recognized by T cell receptors (TCRs). (medigene.com)
TCR-T technology arms a patient's own T cells with tumor-specific T cell receptors. (medigene.com)
T-cell and CD4 receptors on the surface of T cells bind to the HLA protein/T-cell epitope complex in order to generate an immune response. (genengnews.com)
To investigate the effect of hyperglycemia on anti-tumor function induced by anti-PD-1 antibody treatment, we treated STZ-induced diabetic mice with subcutaneous MC38 colon carcinoma tumors with anti-PD-1 antibody, and examined changes in tumor growth, the number of tumor-infiltrating immune cells, and the expression of chemokines and chemokine receptors. (nature.com)
Having examined the nature of the signals required by the T cells for their own survival and sustained functionality, Dr. Sadelain designed improved antigen receptors that provide both activating and co-stimulatory signals to the tumor-targeted T cell. (acgtfoundation.org)

We identified the HLA-A2 restricted T cell epitopes from MAGE-A3 that could effectively induce the activation and cytotoxicity of CD8+ T cells using artificial APC in vitro . (thno.org)
The SQZ AAC platform is designed to induce antigen presentation in vivo by deriving antigen carriers from engineering red blood cells (RBCs) with tumor specific antigens and adjuvants. (stockhouse.com)
Its SQZ TAC platform is designed to induce antigen-specific immune tolerance in vivo by utilizing a similar approach to the AAC platform. (stockhouse.com)
The PK136 antibody has been reported to deplete NK cells, induce redirected lysis, block NK cell function, and induce NK cell proliferation. (rndsystems.com)
Medigene's high-throughput screening technology identified ten peptides as immunogenic and able to induce specific T cell responses. (medigene.com)
Monoclonal antibodies blocking CTLA4 induce regression of immunogenic tumors in mice ( 8 ) and are being pursued as a treatment approach for patients with cancer. (snmjournals.org)
There has been a great deal of interest shown in defining the mechanisms by which anti-CTLA4 antibodies induce tumor regressions in humans. (snmjournals.org)
Donor T cells may also induce GvHD due to recognition of allo-antigens on non-malignant tissues of the patient. (haematologica.org)
Immune checkpoint inhibitors (ICIs), including antibodies against programmed cell death-1 (PD-1) and PD-1 ligand-1 (PD-L1), induce their anti-tumor effects by improving the function of immune cells 11 . (nature.com)
To induce hyperglycemia, mice were intraperitoneally injected with STZ, which can damage pancreatic β cells resulting in the development of insulin dependent diabetes, a model of type 1 diabetes mellitus (T1DM). (nature.com)
Dr. Sadelain demonstrated that human peripheral blood T cells could be effectively redirected to recognize the CO19 antigen and eradicate established, systemic human B cell tumors borne by immunodeficient mice, This was the first publication showing that genetically modified human T cells can induce durable remissions in an in vivo setting. (acgtfoundation.org)
On the other hand, Triphala failed to induce apoptosis or activate ERK or p53 in normal human pancreatic ductal epithelial (HPDE-6) cells. (biomedcentral.com)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

While GB tumors are frequently infiltrated by natural killer (NK) cells, these are actively suppressed by the GB cells and the GB tumor microenvironment. (frontiersin.org)
Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)
Live imaging technology is becoming an increasing popular tool to visualize real-time cellular events in the tumor microenvironment during metastatic progression. (science20.com)
The solid tumor microenvironment contains structural and cellular components that can dictate cancer progression and therapy response. (ubc.ca)
In Chapter 2, I examined how proteins secreted by cancer cells can promote a tumor-permissive microenvironment through the recruitment of suppressive innate and adaptive immune cells to the lungs. (ubc.ca)
This thesis work aims to examine the diverse phenotype and function of myeloid cells in primary and metastatic disease, ultimately contributing to an improved understanding of the interplay between the innate and adaptive immune system in the solid tumor microenvironment. (ubc.ca)
However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)

NK-1.1 has also been shown to play a role in NK cell activation, IFN- gamma production, and cytotoxic granule release. (rndsystems.com)
The cytotoxic T lymphocyte-associated antigen 4 (CTLA4) is a coinhibitory activation-induced surface receptor on T cells that functions as a major negative regulator of anti-self-immune responses. (snmjournals.org)
These cellular components can include cells of the innate immune system, such as myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), and eosinophils, as well as cells of the adaptive immune system, including CD4⁺ T regulatory cells (Tregs) and cytotoxic CD8⁺ T cells. (ubc.ca)
I found that eosinophils were directly cytotoxic towards mammary carcinoma cells, likely through degranulation, and that eosinophils decreased pulmonary metastatic growth of breast cancer cells. (ubc.ca)
Ongoing research investigates mechanisms invoked by cancer cells to abrogate MHC-I expression and attenuate anti-tumour CD8 + cytotoxic T cell response. (portlandpress.com)

The demonstration by Medigene of the immunogenicity of these solid tumor TSAs is an important milestone in the development of new TSA-based immunotherapies. (medigene.com)
In addition, Medigene is establishing a pipeline of TCRs and has collaborations with bluebird bio, Inc. and Cytovant Sciences HK Ltd. addressing solid tumor indications. (medigene.com)

We found that material "X" which promotes cross-presentation by tEC induced strong tumor regression. (nii.ac.jp)
In Chapter 4, I profiled the dynamic myeloid compartment following antigen specific CD8⁺ T cell-mediated tumor regression and recurrence. (ubc.ca)
I demonstrated that using glucose restriction of CD8⁺ T cells in vitro led to improved tumor regression in vivo. (ubc.ca)
I identified several potentially suppressive myeloid cell subsets, including TAMs and arginase-1ʰⁱ monocytic-MDSCs (M-MDSCs) that expand during CD8⁺ T cell-mediated tumor regression and subsequent recurrence, which may play a role in tumor regrowth. (ubc.ca)
The protocol will test whether the T cells that are designed to withstand the toxic effects of the tumor are able to mediate tumor regression in patients with advanced ovarian cancer that has failed to regress after chemotherapy. (acgtfoundation.org)

15 Several second generation anti-CD20 antibodies have recently been developed, and clinical trials are currently ongoing to investigate their in vivo efficacy. (haematologica.org)
Therapeutic antibodies blocking "don't eat me" signals exhibited potent preclinical and early clinical efficacy against solid tumors and hematological malignancies. (aap.com.au)
Finally, the treatment efficacy of DOX-SiNPs-TZ (1:8 Hc-TZ) was evaluated in vivo by PET and supported by MS-based proteomics profiling of tumors. (dovepress.com)
Efficacy was dependent on the number of CD8+ T cells able to recognize tumor antigens that infiltrated the malignant tissue. (unav.edu)
Combining tumor-specific adoptive T cell therapy to the aCTLA-4/aPD1/rIL2 or aCTLA-4/aPD1/aCD137 reg-imens enhances efficacy in a synergistic manner. (unav.edu)
HiCAR-T cells showed enhanced cytotoxicity against tumor cells under hypoxia compared to normoxia in vitro and antitumor efficacy comparable to that of conventional CAR-T cells in vivo. (biomedcentral.com)
T cells expanded ex vivo from a CpG-treated culture demonstrated potent antitumor efficacy and prolonged persistence in vivo. (bmj.com)
This antitumor efficacy was accomplished without in vivo administration of TLR agonists or other adjuvants of high-dose interleukin (IL)-2 or vaccination, which are classically required for effective ACT therapy. (bmj.com)

These peptides were found to be shared among specimens of several patients with solid tumors of different origin, such as ovarian, breast, and lung cancer, but were not detected in healthy tissues, giving them the character of TSAs for TCRs. (medigene.com)
These pre-clinical data support the further development and evaluation of ATG-031 in the Phase I, multicenter, dose escalating clinical trial in patients with solid tumors and hematological malignancies. (aap.com.au)

A clear example of the critical role of CTLA4 on tolerance is the striking phenotype of CTLA4 knock-out mice, which develop rapid T-cell proliferation and autoimmune infiltration of multiple organs shortly after birth ( 6 , 7 ). (snmjournals.org)
Tumor models can be created by inoculating human cancer cells or solid parts of tumors into immune deficient mice. (helsinki.fi)
This concept was supported by similar in vivo monitoring of PYMT mice defective in CSF production (macrophage-deficient), revealing that the absence of macrophages resulted in a significant reduction in streaming chemotaxis and intravasation. (science20.com)
We analyzed the effect of PD-1-Ab on tumor growth in streptozotocin-induced diabetic mice (STZ-mice) subcutaneously inoculated with MC38 (a colon carcinoma cell line). (nature.com)
Furthermore, we assessed the expression of chemokines by polymerase chain reaction (PCR) array in tumor-draining lymph nodes (dLNs) of these mice and MC38 cells cultured in different glucose concentrations. (nature.com)
mRNA expression levels of CXCL9, a chemokine recruiting CD8 + T cells, were lower in dLNs of STZ-mice than in normoglycemic mice after PD-1-Ab treatment, and its protein was expressed in DCs. (nature.com)
Mice were intraperitoneally injected with STZ or sodium citrate buffer (CB) 7 days before subcutaneous inoculation with MC38 cells in the right flank on day 0 (Fig. 1 A). Then, the mice were treated with anti-PD-1 antibody or normal rat IgG on days 5, 8, and 11. (nature.com)
The effect of anti-PD-1 antibody on MC38 tumor is attenuated in STZ-induced diabetic mice. (nature.com)
We show that treatment of the mice with a combination of anti-CTLA-4 + anti-PD1 mAbs results in partial clearance of the tumor with an improvement in survival. (unav.edu)
Reduced tumor-growth in Triphala fed mice was due to increased apoptosis in the tumors cells, which was associated with increased activation of p53 and ERK. (biomedcentral.com)
Using HLA-A2.1 transgenic mice, we have demonstrated the feasibility of T-cell receptor (TCR) gene transfer into T cells to circumvent self-tolerance to the widely expressed human p53 and MDM2 TAAs. (unimedizin-mainz.de)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
2003). The therapeutic effects of different genes delivered by ment of the hGFAP promoter used here has been extensively studied and lentiviral vectors have been documented in a number of animal found to be up-regulated after several different stimuli both in vitro and models, both in rodents and primates, and examples include delivery in vivo in transgenic mice (Brenner et al. (lu.se)

My work involving the depletion of PTPα in TNBC reveals PTPα as a regulator of ECM degradation and invasion in vitro and in vivo. (ubc.ca)
This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)

Antibodies to gag antigens in lions and other large felines indicate the existence of another yet to be identified virus related to feline lentivirus and the ovine/caprine lentiviruses. (wikipedia.org)
The emerging clinical data suggest that a subset of patients with metastatic melanoma treated with CTLA4-blocking antibodies, in the range of 5%−15%, achieve durable objective tumor responses. (snmjournals.org)
CD137 (4-1BB) is a member of the TNFR family that mediates potent T cell costimulatory signals upon ligation by CD137L or agonist monoclonal antibodies (mAbs). (unav.edu)
With antikeratin antibodies, the clear cell acanthomas stain for AE1 and AE3, but did not stain for CAM5.2. (medscape.com)
Recombinant targeting modules will be based on antibodies and soluble single-chain fragments of TCR specific for melanoma antigens. (unimedizin-mainz.de)
Antagonistic Human FcγRIIB (CD32B) Antibodies Have Anti-Tumor Activity and Overcome Resistance to Antibody Therapy In Vivo. (lu.se)

Nevertheless, ex vivo activation with cytokines can restore cytolytic activity of NK cells against GB, indicating that NK cells have potential for adoptive immunotherapy of GB if potent cytotoxicity can be maintained in vivo . (frontiersin.org)
CD20-transduced T cells with and without co-transferred T-cell receptor were efficiently eliminated by complement dependent cytotoxicity induced by therapeutic anti-CD20 antibody rituximab. (haematologica.org)
2) Evrogen's far red fluorescent reporters demonstrating low long-term cytotoxicity, and is ideal for tracing cancer cell metastasis and their susceptibility to treatments. (science20.com)

We demonstrate that MAGEC2 interacts with TRIM28 in melanoma cells and MAGEC2 expression in tumor cells depends on the expression of TRIM28. (biomedcentral.com)
In this study, we found that expression of MAGEC2 protein in tumor cells depends on the expression of TRIM28, a reduction in the level of endogenous TRIM28 expression in melanoma cells resulting in significantly decreased expression of MAGEC2 protein. (biomedcentral.com)
We tested the role of whole-body molecular imaging in patients with advanced melanoma receiving the CTLA4-blocking antibody tremelimumab, allowing the analysis of changes in glucose metabolism using the PET probe 18 F-FDG and cell replication with the PET probe 3′-deoxy-3′- 18 F-fluorothymidine ( 18 F-FLT). (snmjournals.org)
Molecular imaging with the PET probe 18 F-FLT allows mapping and noninvasive imaging of cell proliferation in secondary lymphoid organs after CTLA4 blockade in patients with metastatic melanoma. (snmjournals.org)
Interestingly, vaccination-induced Trm cells strongly suppress the growth of melanoma, independently of circulating CD8 T cells, and were able to infiltrate melanoma tumors. (lifeboat.com)
We successfully applied this strategy to the human TAAs p53, gp100 and MDM2-specific TCRs as promising antigens-driven immunotherapy for both melanoma and hematologic malignancies. (unimedizin-mainz.de)
Focusing on advanced melanoma, we will investigate the antitumor activity of UniCAR NK cells in clinically relevant models. (unimedizin-mainz.de)

Therapeutic cancer vaccination seeks to elicit activation of tumor-reactive T cells capable of recognizing tumor-associated antigens (TAAs) and eradicating malignant cells. (lu.se)
Using syngeneic murine leukemia models, we demonstrate that TR-APCs acquire both myeloid phenotype and function, process and present endogenous TAAs, and potently stimulate TAA-specific CD4+ and CD8+ T cells. (lu.se)
however, they may cause on-target off-tumor toxicity because of minimal expression of tumor-associated antigens (TAAs) on normal tissues, particularly in the context of treating solid tumors. (biomedcentral.com)
However, high-avidity T cells specific for tumor-associated antigens (TAAs) are usually absent in patients because of self-tolerance. (unimedizin-mainz.de)

Finally, we demonstrate the clinical applicability of this approach by generating TR-APCs from primary clinical specimens and stimulating autologous patient-derived T cells. (lu.se)

Therefore, our work highlights the therapeutic potential of vaccination-induced Trm cells to achieve potent protection against skin malignancies. (lifeboat.com)
As the first-in-class anti-CD24 monoclonal antibody entering clinical development, ATG-031 has demonstrated potent anti-tumor activity as a single agent and in combination with chemotherapies and checkpoint inhibitors, as well as excellent safety and PK properties in pre-clinical studies. (aap.com.au)
We have recently demonstrated that vaccination with irradiated murine allogeneic ovarian cancer cells secreting heat shock protein 70 (Hsp70) were capable of generating potent tumor antigen-specific immune responses and strong anti-tumor effects against ovarian cancers (Chang et al. (acgtfoundation.org)
Upon mRNA intratumoral injections in the transplantable mouse cancer models CT26, MC38, and B16OVA, potent therapeutic effects were observed following repeated injections into the tumors. (unav.edu)
CpG fostered the expansion of potent CD8 + T cells with the signature phenotype and antitumor ability via empowering a direct B-T cell interaction. (bmj.com)
Conclusions Our results demonstrate a novel way to use TLR agonists to improve immunotherapy and reveal a vital role for B cells in the generation of potent CD8 + T cell-based therapies. (bmj.com)

Fig. 4: A lower level of CAR-mediated TROG-antigen expression was associated with improved clinical response to CAR-NK cell-based immunotherapy. (nature.com)
The diagnosis and treatment of these cutaneous tumors is constantly evolving, and the role of clinicians relies on accurate diagnosis and a thorough understanding of the clinical sequelae. (medscape.com)
Our clinical studies have shown that EBV-specific T cells generated in vitro will expand, persist, and function for more than 6 years in vivo. (nih.gov)
Its clinical-stage cell therapy candidates include SQZ Enhanced APC (eAPC. (stockhouse.com)
Medigene AG (Medigene, FSE: MDG1, Prime Standard), a clinical stage immuno-oncology company focusing on the development of T cell immunotherapies, today presents the screening and identification of novel immunogenic tumor-specific antigens (TSAs) derived from non-coding regions of the human genome at the American Association for Cancer Research Virtual Annual Meeting (AACR) 2021. (medigene.com)
Medigene concentrates on the development of personalized T cell-based therapies, with associated projects currently in pre-clinical and clinical development. (medigene.com)
We then outline preclinical approaches that employ CAR-NK cells for GB immunotherapy, and give an overview on the ongoing clinical development of ErbB2 (HER2)-specific CAR-NK cells currently applied in a phase I clinical trial in glioblastoma patients. (frontiersin.org)
Recently the research findings from the laboratory and in experimental animals are translated to an early clinical study in which cancer patients are injected with and experimental tumor-specific peptide-conjugate vaccine. (universiteitleiden.nl)
This clinical translational proposal aimed to assess the therapeutic potential of genetically targeted T cells in the treatment of leukemia and lymphoma. (acgtfoundation.org)
The engineered T cells eradicate large tumors in pre-clinical experiments. (acgtfoundation.org)
Based on the encouraging preclinical data, we propose to generate a clinical grade tumor cell-based vaccine engineered to secrete high levels of Hsp70. (acgtfoundation.org)
Overall, our study demonstrates the potential of the HiCAR for improving the safety of CAR-T cells to promote the clinical application of CAR-T immunotherapy. (biomedcentral.com)
A lot of preclinical and clinical studies have confirmed the feasibility of using radionuclide molecular imaging to detect tumor and predict response to therapy [ 12 , 13 ]. (hindawi.com)
Tumour-specific expression of MHC-I and MHC-II has been associated with improved patient survival in most clinical studies. (portlandpress.com)
Our findings have immediate implications in the clinical treatment of advanced solid tumors. (bmj.com)
The treatment and diagnosis of many cutaneous tumors is continually changing, and the role of clinicians (eg, primary care physicians, dermatologists, plastic surgeons, pathologists) focuses on an accurate diagnosis and a thorough understanding of the clinical sequelae. (medscape.com)
Typically, the clinical presentation of clear cell acanthoma is a solitary nodule in the lower extremities. (medscape.com)
Promising combinations of UniCAR NK cells and distinct targeting molecules will be identified for subsequent translation into a phase clinical study. (unimedizin-mainz.de)
Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)

In fact, clear cell acanthoma possesses a similar staining pattern to inflammatory dermatoses such as psoriasis vulgaris, lichen planus, and discoid lupus erythematosus and might be a localized form of inflammatory eruption rather than a neoplasm. (medscape.com)

Cutaneous tumors encompass a vast array of malignancies, ranging from neuroendocrine to lymphoid in origin. (medscape.com)
The origin of cutaneous tumors can be simplistically divided into three major categories: epidermal, dermal, and adnexal (see image below). (medscape.com)
In addition, these rare cutaneous tumors are often difficult to diagnose based solely on the physical examination findings, and the proper diagnosis relies on excisional biopsy with histologic studies. (medscape.com)

We further show that both hematologic cancers and solid tumors, including sarcomas and carcinomas, are amenable to myeloid-lineage reprogramming into TR-APCs. (lu.se)
Memory CD8 + T cell responses have the potential to mediate long-lasting protection against cancers. (lifeboat.com)
Emerging evidence indicates that Trm cells develop in human solid cancers and play a key role in controlling tumor growth. (lifeboat.com)
While UV1 implements specific amino acid chains representative of the human telomerase enzyme's (hTERT) reverse transcriptase subunit to help the native immune response target cancer cells, cancer vaccines that utilize mRNA technology have therapeutic potential in low-treatment option cancers, including many of those linked to occupational hazards. (biospace.com)
These bacterial antigens trigger a strong immune response against cancers in animal models, allowing the effective treatment of the disease. (labiotech.eu)

The observation that the immune system can also attack malignant cells has been known for many years but the cellular and molecular mechanisms have become clear in the last decades. (universiteitleiden.nl)
1 , 2 The anti-tumor effect of DLI is mediated by donor T cells recognizing allo-antigens on the malignant cells of the recipient. (haematologica.org)

Anti-angiogenesis is a way of strangulating the blood supply of a tumor, since without new blood, the tumor cannot survive. (acgtfoundation.org)
Angiogenesis, the growth of new blood vessels, is critical for the development and progression of cancerous tumors. (acgtfoundation.org)

Tumor Biology (2016) 37 (12): 15687. (aacrjournals.org)
Ferry A. Ossendorp is Professor Molecular Vaccin Biology and head of the Tumor Immunology group in the department Immunology of the Leiden University Medical Centre. (universiteitleiden.nl)
Single-cell RNA-sequencing (scRNAseq) was used to better understand the biology of immune responses induced by ATG-101. (aap.com.au)

Although immune checkpoint blockade (ICB) reinvigorates anti-tumor immune responses by disrupting co-inhibitory T-cell signaling, relapse frequently occurs after ICB treatment and acquired resistance often emergence after initial response [ 4 ]. (thno.org)
CD24 is a small, highly glycosylated cell adhesion protein that functions as a novel "don't eat me" target in cancer, where it is the dominant innate immune checkpoint. (aap.com.au)
EO2315 has already demonstrated its capacity to potently kill tumor cells in the lab and control tumor growth when used with a checkpoint inhibitor in vivo . (labiotech.eu)

Lentiviruses can integrate a significant amount of viral complementary DNA into the DNA of the host cell and can efficiently infect nondividing cells, so they are one of the most efficient methods of gene delivery. (wikipedia.org)
Gene regulatory proteins: Tat: main trans-activator Rev: important for synthesis of major viral proteins Accessory proteins: Nef: negative factor Vpr: regulatory protein Vif: APOBEC3 inhibitor Vpu/Vpx: unique to each type of HIV p6: part of gag Serological relationships: Antigen determinants are type-specific and group-specific. (wikipedia.org)
Here, we have revealed the role of viral FLICE-inhibitory protein (vFLIP) in the initiation of PEL and MCD by specifically expressing vFLIP at different stages of B cell differentiation in vivo. (jci.org)
These results define immunological functions for vFLIP in vivo and reveal what we believe to be a novel viral-mediated tumorigenic mechanism involving B cell reprogramming. (jci.org)
The study will research treatment of tumors using a targeted non-viral mode of delivery. (acgtfoundation.org)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
There are a number of hypothesized that regulating the transgene with a GFAP promoter in a different vectors that transduce cells in the brain in a slightly different viral vector would give rise to a high transgenic expression in the manner (for a review see, e.g. (lu.se)

In this study, we comprehensively screened HLA-A2 restricted MAGE-A3 tumor epitopes and characterized the corresponding TCRs using in vitro artificial antigen presentation cells (APC) system, single-cell transcriptome and TCR V(D)J sequencing, and machine-learning. (thno.org)
Furthermore, the tumor-reactive TCRs with killing potency was screened and verified. (thno.org)
Importantly, T cells artificially expressing the MAGE-A3-Mp4 specific TCRs exhibited strong MAGE-A3+ tumor cell recognition and killing effect. (thno.org)
This work identified candidate TCRs potentially suitable for TCR-T design targeting HLA-A2 restricted MAGE-A3 tumor antigen. (thno.org)
TCRs of T cell clones recognizing these novel peptides were determined by gene sequencing and their characterization is ongoing. (medigene.com)
4 In addition, TCRs for minor histocompatibility antigens, including HA-1 and HA-2, have been transferred to donor-derived virus-specific T cells to treat patients with hematologic malignancies after allogeneic stem cell transplantation. (haematologica.org)

The current research aims to better understand the vaccination mechanisms and develop ways to influence the suppressive environment in tumors to allow effective immunotherapy. (universiteitleiden.nl)
Cancer cells can exploit normal mechanisms of cellular motility to facilitate invasion and metastasis, the process by which cancer cells disseminate to distant organs. (ubc.ca)
Additionally, induced co -expression of luciferase, EGFP, and the melanosomal antigen gp100 facilitates studies on the underlying immunological mechanisms. (unav.edu)
This review provides a comprehensive overview of physiologically conserved or novel mechanisms utilised by tumour cells to reduce MHC-I or MHC-II expression. (portlandpress.com)

Genomic DNA was extracted from the remaining blood and used in Plasmodium specific photo-induced electron transfer polymerase chain reaction (PET-PCR) and Nested PCR, whilst the HRP2 antigen content of the DBS was estimated using a bead immunoassay. (cdc.gov)

Under a collaboration agreement with IRICoR and the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal, Canada, Medigene gained access to 47 potential TSAs presented by one of five common HLA types that were identified as novel peptides eluted from the HLA molecules of tumor cells. (medigene.com)
It provides a dominant negative signaling to T cells on binding to the costimulatory molecules CD80 (B7.1) and CD86 (B7.2) expressed on the surface of antigen-presenting cells ( 1 ). (snmjournals.org)
Cell surface CTLA4 has 100-1,000 times higher affinity for the costimulatory molecules expressed by antigen-presenting cells, thereby efficiently competing with the positive costimulatory receptor CD28 ( 1 ). (snmjournals.org)
The engagement of CTLA4 by costimulatory molecules results in decreased T-cell receptor signaling, interleukin 2 transcription ( 3 ), and cell cycle arrest at the G1 stage, with the final result of inducing T-cell anergy ( 4 , 5 ). (snmjournals.org)
Intradermal, but not intraperitoneal vaccination, generated memory precursors expressing skin-homing molecules in circulation and Trm cells in skin. (lifeboat.com)

Such TSAs can provide new targets that allow improved discrimination between cancer cells and healthy tissues by T cells. (medigene.com)
CD24 is extensively expressed in a variety of tumor types, whereas its distribution in normal tissues is limited. (aap.com.au)
This design, founded on the oxygen-dependent degradation domain (ODD), might be particularly useful for targeting common antigens shared between normal and neoplastic tissues. (biomedcentral.com)
But for the most part, normal tissues and 9 cell lines). (lu.se)
Inhaled multi-walled carbon nanotubes caused time-dependent accumulation in multiple tissues, pleural and nuclear penetration, as well as strong tumour-promotion (Mercer et al. (cdc.gov)

Advanced non-small cell lung cancer (NSCLC) is the most common type of lung cancer with poor prognosis. (thno.org)
Non-small cell lung cancer (NSCLC), the most common subtype, comprised approximately 85% of the newly diagnosed lung cancer cases [ 2 ]. (thno.org)
Here, we present a cancer vaccination approach utilizing myeloid lineage reprogramming to directly convert cancer cells into tumor reprogrammed-antigen presenting cells (TR-APCs). (lu.se)
In vivo TR-APC induction elicits clonal expansion of cancer-specific T cells, establishes cancer-specific immune memory, and ultimately promotes leukemia eradication. (lu.se)
Cancer/testis antigen MAGEC2 (also known as HCA587) is highly expressed in a wide variety of tumors and plays an active role in promoting growth and metastasis of tumor cells. (biomedcentral.com)
However, little is known for the regulation of MAGEC2 expression in cancer cells. (biomedcentral.com)
Our findings show that TRIM28 is necessary for MAGEC2 expression in cancer cells, and TRIM28 may serve as a new potential target for immunotherapy of cancer. (biomedcentral.com)
To our knowledge, this is the first time to report the role of TRIM28 in regulating the expression of cancer/testis antigen MAGEC2. (biomedcentral.com)
We are very proud to demonstrate that our high-throughput functional T cell screening approach proves to be a key tool in development of TCR-based cancer immunotherapies that can target a new class of TSAs based on peptides derived from non-coding genetic regions expressed by tumor cells. (medigene.com)
We look forward to learning whether this novel class of TSAs will form a strong basis for T cell-based immunotherapies that can reach more patients who are in need of new therapeutic options to treat cancer. (medigene.com)
This immunotherapy approach attempts to overcome the patient's tolerance towards cancer cells and tumor-induced immunosuppression by activating and modifying the patient's T cells outside the body (ex vivo). (medigene.com)
He followed his postdoc research in the Netherlands Cancer Institute on the role of T cell functions in cancer. (universiteitleiden.nl)
For more than 25 years Ferry Ossendorp is investigating the immune system and cancer and is now head of the Tumor Immunology Group. (universiteitleiden.nl)
• Cellectis SA , of Paris, announced that the Institut Gustave Roussy cancer center in Villejuif succeeded in inducing the correction of a mutation in a cell line isolated from a xeroderma pigmentosum (XP) patient by means of meganuclease-induced gene correction. (bioworld.com)
Androgens play an important role in the pathogenesis of prostate cancer and prostate tumors are usually dependent on androgens. (helsinki.fi)
Numerous in vivo models of prostate cancer have been developed. (helsinki.fi)
Orthotopic prostate tumor models reflect the abnormal cancer cell-stroma interactions occuring in prostate cancer. (helsinki.fi)
Imaging techniques, such as optical imaging, are being utilized in different in vivo models of prostate cancer. (helsinki.fi)
The objective of the experimental part of this thesis was to optimize bioluminescence imaging method in androgen responsive cell line LNCaP-luc2 in orthotopic model of prostate cancer. (helsinki.fi)
In the AACR 2012 symposium entitled, "Immune Cell Function and Cancer In Vivo: Visualizing Friends and Foes", there were two remarkable presentations showing stunning real-time revelations on the role of immune cells in cancer. (science20.com)
First, Dr. John Condeelis used multiphoton microscopy in a mammary imaging window to monitor macrophage and tumor cell interactions in a metastatic mouse PYMT breast cancer model. (science20.com)
His videos revealed a stunning array of "streaming chemotaxis" in which macrophages and cancer cells are alternatively lined up in a stream during their trafficking to the nearby blood vessels. (science20.com)
Condeelis further revealed clusters of macrophages along the blood vessels that are colocalized with the site to tumor cell intravasation, suggesting the integral role of macrophages in the cancer cell's journey into circulation. (science20.com)
Departing from Condeelis' theme is the talk by Dr. Christopher Contag, who used real-time whole-body tracing to track the synergistic tumor-killing activity of cytokine-induced killer (CIK) cells and oncolytic vaccinia virus (vv) in a mouse xenograft model of ovarian cancer. (science20.com)
CIK cells can kill tumor cells specifically by targeting the cancer-specific marker NKG2D (stress associated antigen). (science20.com)
These breathtaking studies are the few examples showing how powerful in vivo imaging technologies have revolutionized cancer research. (science20.com)
EO2315 was discovered using Enterome's technology platform, which identifies bacterial antigens that are similar to cancer antigens. (labiotech.eu)
Here, I investigate the role of one intrinsic factor (receptor-type protein tyrosine phosphatase alpha) and one extrinsic factor (ionizing radiation) in facilitating cancer cell invasion. (ubc.ca)
Focal adhesion structures bear resemblance to invadopodia, which are dynamic actin-based protrusions that form on the plasma membrane of cancer cells. (ubc.ca)
In this study, I hypothesized that PTPα promotes invadopodia-mediated triple-negative breast cancer (TNBC) cell invasion. (ubc.ca)
Two retrospective studies from Israel 12 and Japan 13 recently reported that diabetes was negatively correlated to overall survival in patients with non-small cell lung cancer (NSCLC) treated with ICIs. (nature.com)
The physical structure of these solid tumors presents a formidable challenge to drug delivery vehicles that need to penetrate and reach all cancer cells in order to be optimally effective. (acgtfoundation.org)
Immunotherapy using gene-transduced tumor cells has emerged as a potentially plausible approach for the control of advanced stage ovarian cancer. (acgtfoundation.org)
Previous studies have demonstrated that glycolysis inhibitors reduce the proliferation of non‑small cell lung cancer (NSCLC) cells by interfering with the aerobic glycolytic pathway. (spandidos-publications.com)
However, the mitochondrial oxidative phosphorylation (OXPHOS) pathway in tumor cells has also been implicated in lung cancer metabolism. (spandidos-publications.com)
There are primarily two types of lung cancer: Non-small cell lung cancer (NSCLC) and SCLC, and the former accounts for ~85% of all lung cancer cases ( 3 ). (spandidos-publications.com)
Certain metabolic alterations, also referred to as metabolic reprogramming, are commonly observed in tumor cells and are proposed to be hallmarks of cancer ( 8 ). (spandidos-publications.com)
The most striking and characteristic metabolic alteration in cancer cells is anomalous glucose metabolism and cancer cells tend to utilize glycolysis to obtain energy even under aerobic conditions via a process called 'aerobic glycolysis' ( 9 ). (spandidos-publications.com)
In the 1920s, Otto Heinrich Warburg discovered that cancer cells, unlike normal cells, use the glycolytic pathway to obtain energy for growth even in the presence of oxygen, which is a phenomenon known as 'aerobic glycolysis' or the Warburg effect ( 9 ), and aerobic glycolysis is a common metabolic phenotype in NSCLC ( 11 ). (spandidos-publications.com)
It has been reported that lung cancer cells exhibit upregulated expression of all key glycolytic enzymes [hexokinase 2 (HK2), phosphofructokinase and pyruvate kinase (PK)] ( 13 ), suggesting that the essential enzymes of the aerobic glycolytic pathway have a critical role in the development of lung carcinoma. (spandidos-publications.com)
This study elucidates the molecular mechanism of Triphala against human pancreatic cancer in the cellular and in vivo model. (biomedcentral.com)
Similarly, Triphala induced apoptosis in another pancreatic cancer cell line BxPC-3 by activating ERK. (biomedcentral.com)
Our preclinical studies demonstrate that Triphala is effective in inhibiting the growth of human pancreatic cancer cells in both cellular and in vivo model. (biomedcentral.com)
In the present study, we demonstrate that Triphala significantly inhibit the proliferation of Capan-2 and BxPC-3 human pancreatic cancer cells. (biomedcentral.com)
Documented knowledge in tumor immunology, with practical experience in in-vivo evaluation of cancer immunotherapies using mouse syngeneic mouse models. (lu.se)
Cancer Cell. (lu.se)
Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)

We developed in vivo method to evaluate the infiltration of tumor specific CTLs in tumors by recognition of tumor antigen on tECs. (nii.ac.jp)
Recent years have seen the emergence of many strategies to spatiotemporally control CAR-T cell activities through regulating antigen recognition [ 5 , 6 ], but the application of tumor environmental signals (e.g., acidosis and hypoxia) may represent an attractive strategy to control CAR-T cells. (biomedcentral.com)
We aimed to develop a CAR design that require both antigen recognition and hypoxia sensing to generate optimal T cell activity, thereby reducing on-target off-tumor toxicity. (biomedcentral.com)

SiNPs-TZ (1:8 Hc-TZ) nanoparticles loaded with Doxorubicin (DOX-SiNPs-TZ) showed a similar DOX delivery capability than Caelyx (at 6 h p.i.), in in vitro and ex vivo assays. (dovepress.com)
In the transplant population, antigen assays or PCR is used (sometimes in conjunction with cytopathology) for diagnosis and treatment determinations. (medscape.com)

Moreover, CD24 is highly expressed in a variety of solid tumors and hematologic malignancies, thus indicating the drug's broad therapeutic opportunity. (aap.com.au)

In this study, we found that cross-presentation of tumor antigen by tumor endothelial cells(tECs) promotes infiltration of tumor specific CTLs in tumors. (nii.ac.jp)

Instead, it inhibits FimH-mediated binding of inflammatory bacteria that are invading the gut, which helps to reduce the production of inflammatory cytokines like tumor necrosis factor (TNF). (labiotech.eu)
This study aimed to determine the effect of the aqueous extract of Gongronema latifolium (AEGL) leaves on the level of tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in rabbits. (techscience.com)

Rosa et al, Science Immunology 2022 ) and has shown recently that the same combination of factors can reprogram tumor cells into antigen presenting cells (Zimmermannova et al, In revision). (lu.se)
PhD in immunology, immune-oncology, tumor immunology, or similar, recently graduated or with less than 3 years of post-graduation experience in academic or industrial environment. (lu.se)

Background Adoptive T cell transfer (ACT) therapy improves outcomes in patients with advanced malignancies, yet many individuals relapse due to the infusion of T cells with poor function or persistence. (bmj.com)
Skin malignancies, Merkel cell carcinoma and rare appendageal tumors. (medscape.com)

These ANN ment, cell-cycle progression, drug treat- with different dyes. (lu.se)

NK cells can enhance T-cell activation without production of cytokines linked to adverse reactions. (unimedizin-mainz.de)
Les numérations plaquettaire et leucocytaire ainsi que la concentration en cytokines (IL-2R, IL-8 et TNF-) ont été me- surées. (who.int)
1 ]. Interleukinc8 (ILc8) and tumour necroc ing PCs prepared from apheresis of single sis factor alfa (TNF-) are some of the donors or from pooled samples, is not still cytokines responsible for NHFR [ 2 ]. (who.int)

The T cell receptor-modified T cells (TCR-T cells) are then able to detect and efficiently kill tumor cells. (medigene.com)

You will take advantage of machine learning methods for single-cell multi-omics in order to decipher disease pathogenesis in relation to treatment response and side effects of cellular immunotherapies. (academics.com)
Previous work from the contributing DKTK partner sites has demonstrated the versatility of this approach in T cells, and showed that it is feasible to derive CAR-engineered, established human NK cells as an off-the-shelf cellular therapeutic. (unimedizin-mainz.de)

It is known that all individuals possess classes of T cells that can recognize these forbidden epitopes. (genengnews.com)

Finally, some particles contribute to altered immunologic and allergic responses by functioning as adjuvants or by enhancing the environmental dispersal of antigens (Beezhold et al. (cdc.gov)

Fig. 2: Impact of antigen-induced self-engagement on CAR-NK effector cell phenotype and function. (nature.com)
Fig. 3: Impact of TROG-antigen acquisition on CAR-NK cell phenotype and function in vivo. (nature.com)

The data support the broad value of CD20 as safety switch in adoptive T-cell therapy. (haematologica.org)
In this study, we investigated the use of CD20 as safety switch after retroviral transfer to T cells with different cytomegalovirus (CMV) specificities, and conclude that CD20 may be broadly applicable as safeguard in adoptive T-cell therapy. (haematologica.org)

NK-1.1 surface antigen is encoded by the NKR-P1B/NKR-P1C gene, also known as CD161b/CD161c and Ly-55. (rndsystems.com)
B cell-derived tumors arose at high incidence and displayed Ig gene rearrangement with downregulated expression of B cell-associated antigens, which are features of PEL. (jci.org)
Here we demonstrated that a single intradermal administration of gene- or protein-based vaccines efficiently induces specific Trm cell responses against models of tumor-specific and self-antigens, which accumulated in vaccinated and distant non-vaccinated skin. (lifeboat.com)
The use of CD20 as suicide gene was investigated in CMV specific T cells and in T cells genetically modified with an antigen specific T-cell receptor. (haematologica.org)
Herpes simplex virus thymidine kinase (HSV-tk) is a well-established suicide gene that has been successfully used to control GvHD following donor lymphocyte infusions (DLI) after allogeneic stem cell transplantation. (haematologica.org)
T-cell receptor (TCR) gene transfer is an attractive strategy for rapid in vitro generation of high numbers of antigen specific T cells. (haematologica.org)
A safety concern of TCR gene transfer is the risk of pairing between introduced and the naturally expressed endogenous TCR chains, resulting in the generation of self-reactive T cells. (unimedizin-mainz.de)
The authors used artificial neural croarrays is to study changes in gene ex- .nature organ the tumor arose from, how big it networks (ANNs) to identify gene-ex- pression that accompany changes in is, and what it looks like after it has pression signatures associated with spe- cell physiology, such as during develop- been imbedded in wax and colored cific subtypes of tumors. (lu.se)
The vast majority of these cells did not divide, suggesting that the transgene was indeed regulated in a similar fashion as the endogenous GFAP gene. (lu.se)

SiNPs-TZ (1:8 Hc-TZ) tumor uptake was significantly greater than that of SiNPs-TZ (1:2 Hc-TZ) at 6 hours post-injection (p.i.) in ex vivo biodistribution experiment. (dovepress.com)
In positron emission tomography (PET)/CT, the high rate of glycolysis in NSCLC is reflected by the high uptake of 18F-fluorodeoxyglucose at the corresponding tumor sites ( 12 ). (spandidos-publications.com)

Growth of the orthotopic tumor is difficult to monitor without measuring serum prostate specific antigen (PSA) concentrations or using specific imaging methods. (helsinki.fi)
Cell reports methods. (lu.se)

Here, we demonstrated that intradermal administration of clinically relevant vaccines efficiently induces Trm cells specific for tumor-specific and self-antigens that accumulate in vaccinated and non-vaccinated skin. (lifeboat.com)
Moreover, clinically applicable vaccination strategies that efficiently establish Trm cell responses remain largely unexplored and are expected to strongly protect against tumors. (lifeboat.com)
The goal of this research is to develop synthetic nanoparticles that efficiently penetrate solid tumors. (acgtfoundation.org)

Trogocytosis is an active process that transfers surface material from targeted to effector cells. (nature.com)
This joint (Frankfurt/Mainz, Dresden, Essen, Heidelberg) translational immunotherapy project aims to combine NK cells as effector cells with universal epitope-specific CAR (UniCAR) with tunable activity. (unimedizin-mainz.de)

Fig. 6: AI-CAR-expressing NK cells showed superior in vivo antitumor activity. (nature.com)
Also at the meeting, we released results on AnTenGager TM , an inhouse-developed and fully-patented T cell engager (TCE) platform that offers target-dependent T cell activation and enhanced antitumor activity with reduced risk of cytokine release syndromes. (aap.com.au)

Importantly, CIKs must be pre-infected with vaccinia virus, and that vaccinia virus must be delivered by CIKs, in order to achieve this level tumor specificity, suggesting remarkable synergy between CIKs and vaccinia virus. (science20.com)
The UniCAR is only activated upon cross-linking through a soluble tumor-targeting module carrying the UniCAR binding epitope, thereby achieving highest tumor specificity. (unimedizin-mainz.de)
T cells and TCR will be obtained from blood and tumor tissue and tested for neoantigen specificity and tumor reactivity. (unimedizin-mainz.de)

I demonstrated that tumor cells secreted proteins that drove the recruitment and/or expansion of pulmonary TAMs, Tregs, and granulocytic-MDSCs (G-MDSCs), resulting in increased primary lung tumor growth and pulmonary metastasis of mammary carcinoma cells, respectively. (ubc.ca)

These results suggest that the STZ-induced hyperglycemia impairs the effect of PD-1-Ab treatment on MC38 tumor growth, and is accompanied by reduced infiltration of DCs and CD8 + T cells and decreased expression of CCL7 and CXCL9. (nature.com)

1) Dr. Contag's newest implantable confocal microscope featuring 3D YZ and XY stacked tumor videos, as well as Pulse Electron Avalanche Knife tissue sampler to allow concise and accurate tissue sampling. (science20.com)
Given the vast differences in metabolism between healthy and tumor cells, there is hope that selective targeting of tumor metabolism may be achieved while limiting toxicity to healthy tissue. (spandidos-publications.com)

However, systematic analysis of T cell immune responses to MAGE-A3 antigen and corresponding antigen-specific TCR is still lacking. (thno.org)
By comparing responses to different amino acid sequences, a T-cell epitope map can be built up which allows the scientist to predict what modification can be designed into the Factor VIII molecule to make it less immunogenic. (genengnews.com)
Toll-like receptor (TLR) agonists can invigorate antitumor T cell responses when administered directly to patients, but these responses often coincide with toxicities. (bmj.com)
Peripheral blood mononuclear cells (PBMCs) are used from influenza vaccinated individuals to assess antigen-specific responses to influenza, measles, and varicella. (cdc.gov)

The SQZ eAPC platform is the second-generation product candidate designed to generate tumor specific CD8+ T cell activation to drive the antitumor immune response. (stockhouse.com)
This is due to the fact that certain amino acid sequences, so-called T-cell epitopes, when presented by antigen-presenting cells and recognized by helper T cells, will stimulate a powerful immune response. (genengnews.com)
Therapeutic vaccination has the major advantage that the induced immune response selectively attacks tumors while leaving the healthy cells untouched. (universiteitleiden.nl)

Targeting tumor-secreted proteins, or the suppressive immune cells that are expanded in response to said proteins, led to a decrease in primary and metastatic pulmonary disease. (ubc.ca)
The suppressive effect of PD-1-Ab on tumor growth was attenuated. (nature.com)

Clear cell acanthoma usually stains positively for epithelial membrane antigen and negatively for carcinoembryonic antigen. (medscape.com)

Potential effects of forced CD20 expression on T-cell function were investigated by comparing CD20- and mock-transduced cytomegalovirus (CMV) specific T cells for cytolysis, cytokine release and proliferation. (haematologica.org)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)

Anatomy21

Organisms9

Diseases71

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes45

Disciplines and Occupations1

Information Science4

Health Care7

Immunity12

Lymphocytes13

Dendritic8

Chimeric8

Receptors6

Induce13

Microenvironment8

Cytotoxic5

Solid tumor2

Regression5

Efficacy8

Patients with solid tumors2

Mice15

Vitro and in vivo3

Antibodies6

Cytotoxicity3

Melanoma7

TAAs4

Autologous1

Potent6

Clinical19

Neoplasm1

Cutaneous tumors3

Cancers5

Malignant cells2

Angiogenesis2

Biology3

Checkpoint3

Viral7

TCRs6

Mechanisms4

Polymerase chain re1

Molecules5

Tissues5

Cancer47

Recognition3

Assays2

Hematologic malignancies1

Endothelial cells1

Necrosis factor2

Immunology2

Malignancies2

Progression1

Cytokines3

Receptor-modified T cells1

Cellular2

Recognize1

Adjuvants1

Phenotype and function2

Adoptive T-cell therapy2

Gene9

Uptake2

Methods2

Efficiently3

Effector cells2

Antitumor activity2

Specificity3

Lung1

Infiltration1

Tissue2

Responses4

Immune response3

Suppressive2

Carcinoembryonic1

Proliferation2