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  • arrest
  • Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G 1 cell cycle arrest with p16 INK4A , p21 CIP1/WAF1 , and cyclin D 1 playing key roles in MRT cell growth control. (aacrjournals.org)
  • However, we have shown that reexpression of hSNF5 induced cell cycle arrest in the absence of p16 INK4A expression. (aacrjournals.org)
  • These results indicate that the mechanism of hSNF5-induced cell cycle arrest is context dependent. (aacrjournals.org)
  • We found that G 1 cell cycle arrest occurred concomitant with an increase in p21 CIP1/WAF1 mRNA and protein levels and preceded p16 INK4A mRNA and protein upregulation. (aacrjournals.org)
  • Reexpression of hSNF5 induces G 1 cell cycle arrest in MRT cell lines, accompanied by upregulation of p16 INK4A and downregulation of cyclin D 1 , cyclin A, and phosphorylated retinoblastoma protein (pRb), suggesting a key role for these genes in MRT cell cycle control ( 17 - 20 ). (aacrjournals.org)
  • A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2. (semanticscholar.org)
  • the common consensus is that p16's cell-cycle arrest function plays a primary role in these actions, with some additional apoptotic induction by p16. (jcancer.org)
  • Shortly after DPS injection, significant cell cycle arrest was observed in CECs at both G1/S and G2/M checkpoints, which was accompanied by the activation of cell cycle inhibitors p21 and growth arrest and DNA-damage-inducible protein 45 alpha (GADD45A). (osti.gov)
  • that DPS activated ataxia telangiectasia mutated (ATM), an important inducer of DNA damage repair and cell cycle arrest. (osti.gov)
  • The histamine receptor-1 (H1)-antagonist, loratadine has been shown to inhibit growth of human colon cancer xenografts in part due to cell cycle arrest in G2/M. Since this is a radiation sensitive phase of the cell cycle, we sought to determine if loratadine modifies radiosensitivity in several human tumor cell lines with emphasis on human colon carcinoma (HT29). (springer.com)
  • However, treatment of plateau phase cells also yielded a DMF of 1.3 suggesting that mechanisms other than cell cycle arrest also contribute to loratadine-mediated radiation modification. (springer.com)
  • Like irradiation, loratadine initially induced G2/M arrest and activation of the cell-cycle associated protein Chk1 to pChk1 ser345 , however a subsequent decrease in expression of total Chk1 and Cyclin B correlated with abrogation of the G2/M checkpoint. (springer.com)
  • Taken together, these data suggest that the observed effects of loratadine are multifactorial in that loratadine 1) directly damages DNA, 2) activates Chk1 thereby promoting G2/M arrest making cells more susceptible to radiation-induced DNA damage and, 3) downregulates total Chk1 and Cyclin B abrogating the radiation-induced G2/M checkpoint and allowing cells to re-enter the cell cycle despite the persistence of damaged DNA. (springer.com)
  • P16/Rb pathway collaborates with the mitogenic signaling cascade for the induction of reactive oxygen species, which activates the protein kinase C delta, leading to an irreversible cell cycle arrest. (wikipedia.org)
  • protein
  • Also unknown was whether normal cells could get along without cyclin D1: If not, treating cancer by targeting the protein might be too dangerous. (medindia.net)
  • Annexin 2 is involved in diverse cellular processes such as cell motility (especially that of the epithelial cells), linkage of membrane-associated protein complexes to the actin cytoskeleton, endocytosis, fibrinolysis, ion channel formation, and cell matrix interactions. (wikipedia.org)
  • In order for the cell to continue through the G1-pm, there must be a high amount of growth factors and a steady rate of protein synthesis, otherwise the cell will move into G0 phase. (wikipedia.org)
  • This gene encodes a histone H1 binding protein that is involved in transporting histones into the nucleus of dividing cells. (wikipedia.org)
  • In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. (wikipedia.org)
  • The SAMHD1 protein is also known as: AGS5: Aicardi- Goutières syndrome type 5 DCIP: Dendritic cell-derived IFNG-induced protein2 Mg11: Interferon-gamma-inducible protein HDDC1: HD domain containing 1 MOP-5: Monocyte protein 5 SAMH1_HUMAN SBBI88 CHBL2 The gene encoding human SAMHD1 was originally identified in a human dendritic cell cDNA library as an orthologue of a mouse gene IFN-γ-induced gene Mg11. (wikipedia.org)
  • SAMHD1 was identified as the cellular protein responsible of the reverse transcription block to HIV-1 infection observed in myeloid cells as well as in quiescent CD4+ T cells. (wikipedia.org)
  • SAMHD1 protein expression can be influenced at four levels in cancer cells. (wikipedia.org)
  • mutations
  • The finding that genetic alterations in MRTs are usually limited to hSNF5 mutations and deletions implicates the loss of hSNF5 function as the primary cause of these tumors. (aacrjournals.org)
  • These inactive HDAC1 mutants had a dominant-negative effect on regulating histone acetylation, suggesting a tumor-driving capacity of heterozygous inactivating HDAC1 mutations. (uva.nl)
  • Furthermore, screening for lower HDAC-expression levels and inactivating mutations may serve as diagnostic tools for HDACi sensitivity, since lowered HDAC-activity increased HDACi-mediated tumor cell eradication. (uva.nl)
  • gene
  • Global gene deregulations in FASN silenced retinoblastoma cancer cells: molecular and clinico-pathological correlations. (semanticscholar.org)
  • therefore, this study justifies and promotes the viral-mediated p16 gene therapy as a promising and powerful treatment approach for cancer patients due to p16's multiple anti-tumor functions. (jcancer.org)
  • The tumor suppressor gene p16 (also called MTS1, CDKN2 and INK4A) is a cyclin-dependent kinase (CDK) inhibitor and a negative cell cycle regulator ( 1 ). (jcancer.org)
  • Our previous study demonstrated that introduction of exogenous p16 via adenoviral gene transfer downregulated VEGF expression and inhibited angiogenesis in human BCa cells ( 17 ). (jcancer.org)
  • In human cancer cell lines derived from various tumor types, a high frequency of genetic and epigenetic alterations (e.g., promoter hyper-methylation, homozygous deletion or mutation) in the CDKN2A gene has been observed. (wikipedia.org)
  • survival
  • Despite significant advances in the treatment and outcome of other pediatric tumors, for MRTs diagnosed before the age of 6 months, patient survival at 4 years drops to ∼8.8% ( 4 ). (aacrjournals.org)
  • Further, the expression of cell survival regulatory molecules and hemodynamic characteristics of the tumor milieu were analysed to decipher mechanisms underlying the antitumor action of 3-BP. (ovid.com)
  • Further, 3-BP administration altered the expression of key regulatory molecules involved in glucose uptake, intracellular pH and tumor cell survival. (ovid.com)
  • tissues
  • The authors say the results show that blocking cyclin D "represents a highly selective anticancer strategy that specifically targets cancer cells without significantly affecting normal tissues. (medindia.net)
  • Dogs can develop carcinomas of epithelial cells and organs, sarcomas of connective tissues and bones, and lymphomas or leukemias of the circulatory system. (wikipedia.org)
  • The testicular form is expressed in embryonic tissues, tumor cells, and the testis. (wikipedia.org)
  • It is ubiquitously expressed in many tissues and cell types. (wikipedia.org)
  • human
  • The relationship between tumorigenicity and enhanced chromosomal radiosensitivity during the G 2 cell cycle phase was examined through the use of nontumorigenic human cell hybrids and their nontumorigenic and tumorigenic segregants. (aacrjournals.org)
  • In one experiment, human T-ALL cells were infused into mice that then developed the disease. (medindia.net)
  • In addition to these tests with mouse cancers, the scientists found that the cyclin-D-inhibiting drug had similar effects on human blood cancer cells in the laboratory. (medindia.net)
  • cyclin
  • Blocking cyclin D1 in the mice drove the breast cancer cells into a kind of permanent retirement called senescence, an irreversible halt to their growth cycle. (medindia.net)
  • Rictor depleted cells accumulated G1 phase, and showed prominent downregulation of Cyclin D1. (beds.ac.uk)
  • Biochemical triggers known as cyclin-dependent kinases (Cdks) switch on cell cycles events at the corrected time and in the correct order to prevent any mistakes. (wikipedia.org)
  • Complexes of cyclin that are active during other phases of the cell cycle are kept inactivated to prevent any cell-cycle events from occurring out of order. (wikipedia.org)
  • At the G1/S checkpoint, formation of the G1/S cyclin with Cdk to form a complex commits the cell to a new division cycle. (wikipedia.org)
  • mitotic
  • EMT-6 target cells were synchronized in the M phase by mitotic selection techniques and placed in culture. (aacrjournals.org)
  • Between the beginning of the G1 phase (which is also after mitosis has occurred) and R, the cell is known as being in the G1-pm subphase, or the post-mitotic phase. (wikipedia.org)
  • In cells with a nucleus, as in eukaryotes, the cell cycle is also divided into three periods: interphase, the mitotic (M) phase, and cytokinesis. (wikipedia.org)
  • The word "post-mitotic" is sometimes used to refer to both quiescent and senescent cells. (wikipedia.org)
  • macrophages
  • As the population of target cells proceeded to various discrete phases of the cell cycle in a high degree of synchrony, these cells were challenged with normal macrophages or activated macrophages from Corynebacterium parvum -treated mice, and their subsequent ability to synthesize DNA and undergo mitosis was observed. (aacrjournals.org)
  • Regardless of when normal macrophages were added, they had little effect on the target cells. (aacrjournals.org)
  • In contrast, target cells in the M or G 1 phase at the time of challenge with activated macrophages failed to undergo DNA synthesis (S phase), and their subsequent mitosis was inhibited. (aacrjournals.org)
  • When activated macrophages were added to EMT-6 cells synchronized in the late S or G 2 phase, many of the target cells failed to undergo the impending phase of mitosis. (aacrjournals.org)
  • Moreover, 3-BP reconstituted the external milieu, in concurrence with deregulated glucose and pH homeostasis and increased tumor infiltration by NK cells, macrophages, and T lymphocytes. (ovid.com)
  • SAMHD1 is a cellular enzyme, responsible for blocking replication of HIV in dendritic cells, macrophages and monocytes. (wikipedia.org)
  • subsequent
  • Specifically, the lipid bilayer facilitates uptake into the cell and subsequent release from the endosome, the PEGylated outer layer providing stability during formulation due to the resulting hydrophilicity of the exterior. (wikipedia.org)
  • mice
  • It was originally established as an ascites tumor in mice. (wikipedia.org)
  • Culture techniques in large-scale, mice passage is less attractive, due to the contamination of the tumor with multifarious host inflammatory cells. (wikipedia.org)
  • growth
  • Moreover, we showed that p16 inhibits breast cancer cell growth by inhibiting the VEGF signaling pathway and angiogenesis. (jcancer.org)
  • The outcomes of this study will help in optimizing the therapeutic application of 3-BP by targeting crucial tumor growth regulatory components of tumor milieu. (ovid.com)
  • While Drosophila AKT and its upstream regulators, such as PI3K and PDK1, are essential for viability and cell growth, flies lacking TORC2 are viable and display only minor growth impairment under standard growth conditions. (beds.ac.uk)
  • G1 phase together with the S phase and G2 phase comprise the long growth period of the cell cycle called interphase that takes place before cell division in mitosis (M phase). (wikipedia.org)
  • G1 phase and the other subphases of the cell cycle may be affected by limiting growth factors such as nutrient supply, temperature, and room for growth. (wikipedia.org)
  • Physiological temperatures are optimal for cell growth. (wikipedia.org)
  • The first restriction point is growth-factor dependent and determines whether the cell moves into the G0 phase, while the second checkpoint is nutritionally-dependent and determines whether the cell moves into the S phase. (wikipedia.org)
  • Reasons the cell would not move into the S phase include insufficient cell growth, damaged DNA, or other preparations have not been completed. (wikipedia.org)
  • He demonstrated that growth factors controlled cell cycle regulatory events and has actively studied these processes, including platelet derived growth factor (PDGF) and insulin-like growthfactor-1 (IGF-1) signal transduction. (wikipedia.org)
  • Cancer cells ignore cell cycle regulators that control cell growth, division, and death. (wikipedia.org)
  • chromosomal
  • The hybrids and their nontumorigenic subclones had cytological features which are predominantly found with a benign clinical course and had the G 2 chromosomal radiosensitivity more characteristic of the normal parental cells. (aacrjournals.org)
  • Like tumorigenic cells, fetal cells exhibited enhanced G 2 chromosomal radiosensitivity which could be suppressed in fetal × tumor cell hybrids. (aacrjournals.org)
  • The enhanced G 2 chromosomal radiosensitivity of a tumor cell, which appears to result from deficient DNA repair, is suppressed by fusion with a normal cell. (aacrjournals.org)
  • mechanism
  • Systematic combination of Hdac1 and Hdac2 cKO alleles in murine thymi resulted in dosage-dependent tumor development of monoclonal lymphoblastic lymphomas, characterized by Myc-oncogene overexpression and a novel p53-suppressing mechanism. (uva.nl)
  • Although a comprehensive mechanism was not elucidated, in these prior studies loratadine treatment resulted in anti-tumor effects. (springer.com)
  • Gemcitabine progresses through a similar mechanism, causing cells in the S-phase to disrepair DNA damage caused by the radiation. (wikipedia.org)
  • Tangeretin strengthens the cell wall and acts as a plant's defensive mechanism against disease-causing pathogens. (wikipedia.org)
  • prostate
  • Conclusions: DPS selectively radioprotected normal intestinal CECs and sensitized prostate cancer cells in a clinically relevant model. (osti.gov)
  • HeLa
  • cervix cancer HeLa) obtained with MTT-test and cell counts were performed using a tripan blue dye. (oalib.com)
  • In the present study we demonstrate a detectable cytostatic effect of the maleimide derivative MI1 on the epithelial cell lines Colo-205, MCF-7 and HeLa. (oalib.com)
  • molecular
  • Cell cycle molecular targets in novel anticancer drug discovery. (semanticscholar.org)
  • Warren Jackson (Jack) Pledger is a molecular cell biologist who is the Associate Director for Research and Deputy Director of the Gibbs Cancer Research Institute in Spartanburg, South Carolina. (wikipedia.org)
  • He has over 150 publications in journals, including Science, Nature, Proceedings of the National Academy of Sciences, USA, Molecular Cell Biology, and Journal of Cell Biology. (wikipedia.org)
  • lines
  • The cancerous cell lines are transmitted between individuals that are in close contact with each other through acts of intercourse, biting, scratching, or licking. (wikipedia.org)
  • enhances
  • Other studies demonstrated that silencing SAMHD1 enhanced HIV-1 and SIV Δvpx infection of myeloid cells, also enhances HIV-1 infection of resting CD4+ T cells. (wikipedia.org)
  • kinases
  • The cell cycle kinases. (semanticscholar.org)
  • AKT kinase activity is principally determined by the level of phosphatidylinositol-3,4,5-triphosphate (PIP3) in the plasma membrane of cells, which is generated by phosphatidylinositol-3-kinase (PI3K) upon stimulation of receptor tyrosine kinases. (beds.ac.uk)
  • interphase
  • G1 phase ends when the cell moves into the S phase of interphase. (wikipedia.org)
  • During interphase, the cell grows, accumulating nutrients needed for mitosis, preparing it for cell division and duplicating its DNA. (wikipedia.org)
  • After cell division, each of the daughter cells begin the interphase of a new cycle. (wikipedia.org)
  • Although the various stages of interphase are not usually morphologically distinguishable, each phase of the cell cycle has a distinct set of specialized biochemical processes that prepare the cell for initiation of cell divisions. (wikipedia.org)
  • The cell cycle consists of four distinct phases: G1 phase, S phase (synthesis), G2 phase (collectively known as interphase) and M phase (mitosis). (wikipedia.org)
  • Interphase is a series of changes that takes place in a newly formed cell and its nucleus, before it becomes capable of division again. (wikipedia.org)
  • Previously it was called resting stage because there is no apparent activity related to cell division.Typically interphase lasts for at least 90% of the total time required for the cell cycle. (wikipedia.org)
  • tissue
  • This study will also look at specific substances called biomarkers in your blood, and in the tumor tissue which are involved in the growth of tumor cells, and determine if the levels of these biomarkers are related to your response to treatment or development of side effects. (clinicaltrials.gov)
  • In addition, given the risks of using animal serum for tissue engineering, autologous blood may gain favor as a source of growth factors and serum supplements needed for stimulating cells to engineer intervertebral disc tissues. (blogspot.com)
  • Applications of phage display technology include determination of interaction partners of a protein (which would be used as the immobilised phage "bait" with a DNA library consisting of all coding sequences of a cell, tissue or organism) so that the function or the mechanism of the function of that protein may be determined. (wikipedia.org)
  • Gilmour continued her research at The Wistar Institute in Philadelphia, Pennsylvania, first as postdoctoral fellow (1984 to 1987) and then as research associate (1988 to 1990 While at Wistar, she began her work in characterizing the regulation and expression of ornithine decarboxylase (ODC) in both normal and tumor tissue. (wikipedia.org)
  • It is not detectable in non-proliferating normal tissue but is detectable in many human tumors. (wikipedia.org)
  • senescent cells
  • Although senescent cells can no longer replicate, they remain metabolically active and commonly adopt an immunogenic phenotype consisting of a pro-inflammatory secretome, the up-regulation of immune ligands, a pro-survival response, promiscuous gene expression (pGE) and stain positive for senescence-associated β-galactosidase activity. (wikipedia.org)
  • The nucleus of senescent cells is characterized by senescence-associated heterochromatin foci (SAHF) and DNA segments with chromatin alterations reinforcing senescence (DNA-SCARS). (wikipedia.org)
  • Senescent cells affect tumour suppression, wound healing and possibly embryonic/placental development and a pathological role in age-related diseases. (wikipedia.org)
  • The word "post-mitotic" is sometimes used to refer to both quiescent and senescent cells. (wikipedia.org)
  • cellular
  • Scientific discoveries: Gilmour's study of polyamines has broadened the scope of medical knowledge about tumor function at the cellular and molecular levels. (wikipedia.org)
  • Cellular senescence is the phenomenon by which normal diploid cells cease to divide. (wikipedia.org)
  • As such, cellular senescence represents a change in "cell state" rather than a cell becoming "aged" as the name confusingly suggests. (wikipedia.org)
  • Consistent with this, telomerase-immortalised cells continued to age (according to the epigenetic clock) without having been treated with any senescence inducers or DNA-damaging agents, re-affirming the independence of the process of epigenetic ageing from telomeres, cellular senescence, and the DNA damage response pathway. (wikipedia.org)
  • Receptors
  • Adrenocorticotropic hormones bind to ACTH receptors on the cells within the adrenal medulla and adrenal cortex, causing a signal cascade within the adrenomedullary cell, ultimately releasing the neurotransmitter acetylcholine. (wikipedia.org)
  • immune
  • Cardiac arrest Cytokine release syndrome Tumor lysis syndrome, causing acute renal failure Infections Hepatitis B reactivation Other viral infections Progressive multifocal leukoencephalopathy (PML) Immune toxicity, with depletion of B cells in 70% to 80% of lymphoma patients Pulmonary toxicity Bowel obstruction and perforation Two patients with systemic lupus erythematosus died of progressive multifocal leukoencephalopathy (PML) after being treated with rituximab. (wikipedia.org)
  • Disease
  • In a Phase 1/2 trial, in solid tumor patients refractory to standard therapy, response evaluation showed disease stabilization in a majority of patients. (wikipedia.org)
  • Junctions
  • β-catenin acts by anchoring the actin cytoskeleton to the junctions, and may possibly aid in contact inhibition signaling within the cell. (wikipedia.org)
  • For instance, when an epithelial layer is complete and the adherens junctions indicate that the cell is surrounded, β-catenin may play a role in telling the cell to stop proliferating, as there is no room for more cells in the area. (wikipedia.org)
  • α-catenin participates in the formation and stabilization of adherens junctions by binding to β-catenin-cadherin complexes in the cell. (wikipedia.org)
  • triggers
  • Biochemical triggers known as cyclin-dependent kinases (Cdks) switch on cell cycles events at the corrected time and in the correct order to prevent any mistakes. (wikipedia.org)
  • telomere length
  • May play also an essential role in telomere length maintenance and telomere capping in mammalian cells. (abcam.cn)
  • Cells can also be induced to senesce via DNA damage in response to elevated reactive oxygen species (ROS), activation of oncogenes and cell-cell fusion, independent of telomere length. (wikipedia.org)
  • Causes
  • When inappropriately activated causes hair follicle derived tumors, the most clinically significant being the BCC. (wikipedia.org)
  • Neurons
  • Non-proliferative (non-dividing) cells in multicellular eukaryotes generally enter the quiescent G0 state from G1 and may remain quiescent for long periods of time, possibly indefinitely (as is often the case for neurons). (wikipedia.org)
  • mitosis
  • Between the beginning of the G1 phase (which is also after mitosis has occurred) and R, the cell is known as being in the G1-pm subphase, or the post-mitotic phase. (wikipedia.org)
  • fluorescence
  • Adjustments in the Ca2+ focus had been indicated as F/F, where F was the fluorescence strength when cells had been at rest, and F was the modification in fluorescence during excitement. (cancercurehere.com)
  • Development
  • However, loss of Gli3 leads to abnormal patterning and loss of Gli2 affects the development of ventral cell types, most significantly in the floor plate. (wikipedia.org)
  • activity
  • Evaluation of cytotoxicity in Human noncancer cells indicated that the compounds 3i and 3m were practically ineffective in quiescent peripheral blood lymphocytes, and may have a selective antiproliferative activity against cancer cells. (deepdyve.com)
  • Melflufen was synthesized, partly due to previous experience of an alkylating peptide cocktail named Peptichemio and its anti-tumor activity is being investigated. (wikipedia.org)
  • expression
  • Over-expression of PPARδ also sensitised THP-1 cells to phorbol ester and correspondingly, inhibition of PPARδ by anti-sense RNA completely abolished this response. (biomedcentral.com)
  • determine
  • The restriction point (R) in the G1 phase is different from a checkpoint because it does not determine whether cell conditions are ideal to move on to the next phase, but it changes the course of the cell. (wikipedia.org)
  • phase
  • Analyses of cell cycle distribution, and morphological microtubules organization showed that compound 3m induced G2/M phase arrest and, dramatically disrupted the microtubule network. (deepdyve.com)
  • The duration of each phase, including the G1 phase, is different in many different types of cells. (wikipedia.org)
  • In humans, the normal physiological temperature is around 37 °C (98.6 °F). G1 phase is particularly important in the cell cycle because it determines whether a cell commits to division or to leaving the cell cycle. (wikipedia.org)
  • If a cell is signaled to remain undivided, instead of moving onto the S phase, it will leave the G1 phase and move into a state of dormancy called the G0 phase. (wikipedia.org)
  • After a vertebrate cell has been in the G1 phase for about three hours, the cell enters a restriction point in which it is decided whether the cell will move forward with the G1 phase or move into the dormant G0 phase. (wikipedia.org)
  • After R and before S, the cell is known as being in G1-ps, or the pre S phase interval of the G1 phase. (wikipedia.org)
  • M phase is itself composed of two tightly coupled processes: karyokinesis, in which the cell's chromosomes are divided, and cytokinesis, in which the cell's cytoplasm divides forming two daughter cells. (wikipedia.org)
  • Cells that have temporarily or reversibly stopped dividing are said to have entered a state of quiescence called G0 phase. (wikipedia.org)
  • G0 is a resting phase where the cell has left the cycle and has stopped dividing. (wikipedia.org)
  • The cell cycle starts with this phase. (wikipedia.org)
  • During this phase, the biosynthetic activities of the cell, which are considerably slowed down during M phase, resume at a high rate. (wikipedia.org)
  • In G1 phase, a cell has three options. (wikipedia.org)
  • known
  • The modified plasmid of this bacterium used is known as Ti plasmid, or tumor inducing (Figure 2). (macalester.edu)
  • Within the cell cycle, there is a stringent set of regulations known as the cell cycle control system that controls the timing and coordination of the phases to ensure a correct order of events. (wikipedia.org)
  • leads
  • She recently developed an animal model to study arsenic-induced skin cancer and to demonstrate that in utero exposure to trace levels of arsenic in drinking water leads to skin tumor formation when the animals mature to young adults. (wikipedia.org)
  • stem
  • Gilmour provided the first evidence that elevated epidermal levels of polyamines alone can positively affect the recruitment of bulge stem cells in the skin. (wikipedia.org)
  • This finding is significant with regard to the stem cell origin of skin cancer, since carcinogen-targeted stem cells can remain dormant for many years until recruited to develop into a tumor. (wikipedia.org)
  • toxicity
  • Hematologic toxicity was common, but manageable with cycle prolongations, dose modifications and supportive therapy, and non-hematologic treatment-related adverse events were infrequent. (wikipedia.org)
  • serum
  • Components and strategies Cell lifestyle MCF-7 cells had been grown up in DMEM moderate filled with 10% fetal leg serum and 1% penicillin/streptomycin serum as defined (9). (cancercurehere.com)
  • affect
  • However, more severe disorders of the sympathoadrenal system such as phaeochromocytoma (a tumor on the adrenal medulla) can affect the body's ability to maintain a homeostatic state. (wikipedia.org)
  • grown
  • Then the cells are grown on a dish with the medium that the antibiotic is resistant to and if the insertion was successful, then cells will grow. (macalester.edu)
  • function
  • Cell-cell adhesion complexes are required for simple epithelia in higher organisms to maintain structure, function and polarity. (wikipedia.org)
  • cytoplasm
  • As a result, its levels in the cell are stabilized as it builds up in the cytoplasm. (wikipedia.org)
  • During the final stage, cytokinesis, the chromosomes and cytoplasm separate into two new daughter cells. (wikipedia.org)
  • response
  • Chromaffin cells contained in the adrenal medulla act as postganglionic nerve fibers that release this chemical response into the blood as circulating messenger. (wikipedia.org)
  • form
  • At the G1/S checkpoint, formation of the G1/S cyclin with Cdk to form a complex commits the cell to a new division cycle. (wikipedia.org)
  • blood
  • The cell-division cycle is a vital process by which a single-celled fertilized egg develops into a mature organism, as well as the process by which hair, skin, blood cells, and some internal organs are renewed. (wikipedia.org)