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  • tissues
  • the greatest accumulation occurred in tissues with a rapid cell turnover. (inchem.org)
  • and (3) experimental approaches have usually neither allowed for any correlation between the structure of neoplastic tissues and therapeutic responses nor revealed the kinetic status of various Cell. (springer.com)
  • Virol
  • Pampeno, C. L. and Meruelo, D., Isolation of a retroviruslike sequence from the TL locus of the C57BL/10 murine major histocompatibility complex, J. Virol. (springer.com)
  • Induction
  • 2009. Proposed algorithm to investigate latent and occult viruses in vaccine cell substrates by chemical induction. (asmscience.org)
  • Induction d'une leucemie virale de gross chez des souris c57bl/6 adultes par injection de cellules akr (k36). (jax.org)
  • Lymphoid
  • Since HRX ‐associated leukemias often express markers of both lymphoid and myeloid lineages, it is possible that HRX translocations may occur at the level of a multipotent hematopoietic progenitor or hematopoietic stem cell (HSC), leading to the disruption of normal genetic programs for terminal differentiation. (embopress.org)
  • The specific subset of NK cell is reported to control the development at the fetal-maternal interface during the first trimester of the pregnancy, and it constitutes about 50-90% of total lymphoid cells in the uterus ( 2 , 3 ). (frontiersin.org)
  • Similar to T and B cells, NK cells also develop from common lymphoid progenitor cells ( 5 ). (frontiersin.org)
  • Rous
  • That was the year that Peyton Rous was awarded the Nobel Prize for Medicine or Physiology for the isolation of his eponymous virus published in 1911, representing a record 55 year incubation period between reporting a discovery and the award [ 6 ]. (royalsocietypublishing.org)
  • Genetic
  • Kumar V., Eckner R. J., Bennett M. Mechanism of genetic resistance to immune suppression by friend leukemia virus: the role of marrow - dependent cells. (medkursor.ru)
  • Genetic diversity of enzootic isolates of vesicular stomatitis virus New Jersey. (asm.org)
  • Alizon M, Wain-Hobson S, Montagnier L, Sonigo P (1986) Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients. (springer.com)
  • Coffin JM (1986) Genetic variation in AIDS viruses. (springer.com)
  • Genetic evidence for vaccinia virus-encoded DNA polymerase: isolation of phosphonoacetate-resistant enzyme from the cytoplasm of cells infected with mutant virus. (asm.org)
  • immune
  • These ERVs affect retrovirus-induced disease in a number of ways, including manipulation of the immune response, inhibition or facilitation of entry or other steps of virus replication, or as participants in the generation of infectious pathogenic viruses. (springer.com)
  • Jeejeebhoy H. F. Stimulation of tumor growth by the immune response. (medkursor.ru)
  • Cell-mediated immune reaction against tumors induced by oncornaviruses. (histrecmed.fr)
  • H-2 region product as determinant in immune cytolysis of syngeneic tumour cells by anti-MSV T lymphocytes. (histrecmed.fr)
  • I. The role of immune mechanism in tumor transplants in the syngeneic host. (jax.org)
  • Immune responses to virus-induced tumours. (jax.org)
  • Early defense against mucosal pathogens consists of both an epithelial barrier and innate immune cells. (jove.com)
  • The resulting infection enables high-resolution imaging of epithelial and innate immune cell behavior throughout the development of mucosal disease. (jove.com)
  • The versatility of this method allows for interrogation of the host to probe the detailed sequence of immune events leading to phagocyte recruitment and to examine the roles of particular cell types and molecular pathways in protection. (jove.com)
  • In an established mouse model of atherosclerosis, infection with P. gingivalis accelerates inflammatory plaque deposition within the aortic sinus and innominate artery, accompanied by activation of the vascular endothelium, an increased immune cell infiltrate, and elevated expression of inflammatory mediators within lesions. (jove.com)
  • Natural killer (NK) cells are innate immune cells that show strong cytolytic function against physiologically stressed cells such as tumor cells and virus-infected cells. (frontiersin.org)
  • After activation, NK cells also secrete several cytokines such as interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), granulocyte macrophage colony-stimulating factor (GM-CSF), and chemokines (CCL1, CCL2, CCL3, CCL4, CCL5, and CXCL8) that can modulate the function of other innate and adaptive immune cells. (frontiersin.org)
  • leukemogenesis
  • This suggests that the enhancers need only a few specific base changes relative to the injected virus to accelerate leukemogenesis. (umassmed.edu)
  • Meruelo, D., A role for elevated H-2 antigen expression in resistance to RadLV-induced leukemogenesis: Enhancement of effective tumor surveillance by killer lymphocytes, J. Exp. (springer.com)
  • encodes
  • Thirteen years later, it was shown that the oncogene transduced by this virus encodes a serine/threonine protein kinase (AKT) (also known as PKB), which harbors an N-terminal regulatory domain (now known as the PH domain) and exhibits a high degree of homology with the kinases PKC and PKA ( 2 - 5 ). (sciencemag.org)
  • Lymphocytes
  • Cytolytic T lymphocytes (CTL) were identified during the late 1960's (1,2) and are thought to be important effector cells in immunity to viruses (3) and in allograft rejection (4), Despite considerable effort during the past decade, little has been learned about the biochemical basis for the killing event. (springer.com)
  • Martz, E. Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. (springer.com)
  • They represent 2-7% of lymphocytes in mouse peripheral blood (PB) and 5-15% of human peripheral blood mononuclear cells (PBMCs). (frontiersin.org)
  • NK cells constitute about 20-30% of total hepatic lymphocytes and 10% of lymphocytes in healthy human liver and lung, respectively ( 1 ). (frontiersin.org)
  • necrosis
  • Adipose tissue is a source of tumor necrosis factor-α, interleukin-6, adiponectin, leptin, and plasminogen activator inhibitor-1 (PAI-1), whose circulating levels display a strong circadian pattern ( 11 - 13 ). (diabetesjournals.org)
  • Cytolytic
  • Multiple target cell killing by the cytolytic T-lymphocyte and the mechanism of cytotoxicity. (springer.com)
  • In this review, we discussed the NK cell phenotypes and its effector function and impact of the tumor microenvironment on effector and cytolytic function of NK cells. (frontiersin.org)
  • translocations
  • In these tumors, Pvt1 is the site of reciprocal translocations to immunoglobulin loci. (biomedcentral.com)
  • A subset of acute leukemias carries translocations of chromosome band 11q23 with reciprocal partners located at 30 or more cytogenetically diverse loci (for a review, see Waring and Cleary, 1997 ). (embopress.org)
  • glycoproteins
  • Effect of tunicamycin on the synthesis of herpes simplex virus type 1 glycoproteins and their expression on the cell surface. (asm.org)
  • simian
  • The late spliced 19S and 16S RNAs of simian virus 40 can be synthesized from a common pool of transcripts. (asm.org)
  • Beth E., Cikes M., Schloen L. Interspecies species- and type - specific determinants of human papovaviruses (JC and BK) and of simian virus 40. (medkursor.ru)