Tumor cells adoptive immunotherapy antigen of tumor. Medical search. Frequent questions

Nevertheless, targeting solid tumors is more challenging than targeting hematological malignancies because of tumor histopathological characteristics, shortage of specific antigens and local strong immunosuppressive microenvironment [ 4 ]. (ijbs.com)
Thus, addressing the presence of immunosuppressive myeloid cell populations in the periphery and tumor microenvironment of patients with cancer is likely to be required for effective NK cell-based immunotherapy. (elifesciences.org)
Also, gene set enrichment analysis (GSEA) and immune infiltrating analyses were conducted to understand function annotation and the role of the signature in the tumor microenvironment. (scielo.br)
In melanoma, whether cells in the microenvironment can endow such competence remains unclear. (bvsalud.org)
SIGNIFICANCE: This study shows evidence of GABA-mediated regulation of electrical activity between melanoma cells and keratinocytes, providing a new mechanism by which the microenvironment promotes tumor initiation. (bvsalud.org)
Glycoprotein nonmetastatic melanoma protein B (GPNMB) has previously been identified as a clinically relevant target in GBM while being absent in normal brain tissues and shown to be active in the tumor immune microenvironment. (bmj.com)
Conclusions We show GPNMB influences tumor intrinsic biology of GBM and is active in the tumor immune microenvironment. (bmj.com)
Also in a xenotransplant model, i.v. injected CD38-CAR T cells were effective against MM tumors growing in a human bone marrow-like microenvironment, thus demonstrating their ability to properly migrate and infiltrate into the tumor niche to lyse malignant cells. (biomedcentral.com)
However, increasing data has indicated that the clinical potential of most immunotherapies is usually hampered by immunosuppressive status of the tumor microenvironment (TME) [ 7 ]. (thno.org)
While many successful immunotherapeutic regimens have relied on checkpoint inhibition, other immunotherapeutic approaches, such as adoptive cellular therapies (ACT), the use of bispecific antibodies, and targeting components of the tumor microenvironment, are showing promise in a variety of cancer types. (aacr.org)
Breakthroughs in anti-tumor immunity have led to unprecedented advances in immunotherapy, yet it is now clear that the tumor microenvironment (TME) restrains immunity. (elifesciences.org)
As T cell metabolism dictates effector function, it is now apparent that the effect of cancer cell metabolism on the tumor microenvironment (TME) may impair anti-tumor immunity, and these new hallmarks of cancer are therefore inextricably linked. (elifesciences.org)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)

Modification with chimeric antigen receptors (CARs) endows T cells with tumor specific cytotoxicity and thus induce anti-tumor immunity against malignancies. (ijbs.com)
NK cells express germ-line receptors that are either stimulatory or inhibitory, and the summation of these signals determines activation status ( Caligiuri, 2008 ). (elifesciences.org)
Chimeric antigen receptors (CARs) are synthetic proteins expressed on the surface of T cells. (medscape.com)
GABA is synthesized in melanoma cells, which then acts on GABA-A receptors in keratinocytes. (bvsalud.org)
Chimeric antigen receptors (CAR)-engineered T cells have demonstrated remarkable efficacy in patients with B-cell malignancies. (unimedizin-mainz.de)
Adoptive transfer of T cells transduced with tumor-reactive Chimeric Antigen Receptors (CARs) is a promising strategy for cancer immunotherapy. (biomedcentral.com)
Generating and characterising chimeric antigen receptors to target the tumour vasculature. (bham.ac.uk)
We have developed a cellular immunotherapy that uses chimeric receptors to selectively redirect therapeutic T cells against myelin basic protein (MBP)-specific T lymphocytes implicated in MS. We generated two heterodimeric receptors that genetically link the human MBP84-102 epitope to HLA-DR2 and either incorporate or lack a TCRzeta signaling domain. (ox.ac.uk)
Both receptors were well expressed on primary T cells or T hybridomas using a tricistronic (alpha, beta, green fluorescent protein) retroviral expression system. (ox.ac.uk)
These results provide support for the further development of redirected therapeutic T cells able to counteract pathologic, self-specific T lymphocytes, and specifically validate humanized MBP-DR2-zeta chimeric receptors as a potential therapeutic in MS. (ox.ac.uk)
Further, inhibitory receptors present in the TME can inhibit T cell metabolism and alter T cell signaling both directly and through release of extracellular vesicles such as exosomes. (elifesciences.org)
Primary T cells expressing chimeric receptors specific for tumor or viral antigens have considerable therapeutic potential. (nih.gov)
They recognize EBV-infected targets through their conventional T-cell receptor and tumor targets through their chimeric receptors. (nih.gov)
EBV-specific T cells expressing chimeric antitumor receptors may represent a new source of effector cells that would persist and function long-term after their transfer to cancer patients. (nih.gov)
Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune checkpoint receptors such as programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) or cytotoxic T lymphocyte antigen-4 (CTLA-4). (biomedcentral.com)
Alternative inhibitory receptors have been identified that may be targeted for anti-tumor immune therapy, such as lymphocyte-activation gene-3 (LAG-3), as have several potential target oncogenes for molecularly targeted therapy, such as tyrosine kinase inhibitors. (biomedcentral.com)
Alternative inhibitory receptors have been identified that may also be targeted for anti-tumor immune therapy. (biomedcentral.com)
These include the T cell immunoglobulin and mucin-domain containing-3 (TIM-3), lymphocyte-activation gene-3 (LAG-3), TIGIT, and B-and T-lymphocyte-associated protein (BTLA) receptors associated with T cell exhaustion and V-domain immunoglobulin suppressor of T cell activation (VISTA), a receptor found on tumor-infiltrating myeloid cells. (biomedcentral.com)

Advances in our understanding on the interaction between the immune system and tumor cells have contributed to the rapid development of novel therapeutic strategies based on chimeric antigen receptor (CAR) or T cell receptor (TCR) modified T cells. (ijbs.com)
Here, we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. (elifesciences.org)
Here, we describe the pre-clinical in vitro and in vivo study of irradiated haNK cells engineered to express a second-generation chimeric antigen receptor (CAR) targeting programmed death-ligand 1 (PD-L1). (elifesciences.org)
Chimeric antigen receptor (CAR) T-cell therapy is a rapidly growing treatment modality. (medscape.com)
Once infused, the cells continue to expand in number and bind to cancer cells via the engineered receptor, resulting in immunologic cancer cell death. (medscape.com)
We examined the site-specificity of T cell receptor (TCR) repertoires across tissues (5 to 18 tissues per patient) in prospectively collected autopsies of patients with and without graft-versus-host disease (GVHD), a potentially lethal tissue-targeting complication of allogeneic hematopoietic cell transplantation, and in mouse models of GVHD. (bvsalud.org)
In an attempt to evaluate the immune response of renal cell carcinoma (RCC) patients, tumor lesions and / or blood samples from 12 RCC patients underwent deep T cell receptor (TCR) sequencing. (oncotarget.com)
1,2 Chimeric Antigen Receptor T-cells (CAR-Ts) fail clinical trials because multiple antigens will be required to eliminate all GBM subpopulations. (bmj.com)
This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4 and CD8 T cells lentivirally transduced to express a HER2-specific chimeric antigen receptor (CAR) and EGFRt, delivered by an indwelling catheter in the tumor resection cavity or ventricular system in children and young adults with recurrent or refractory HER2-positive CNS tumors. (fredhutch.org)
Using HLA-A2.1 transgenic mice, we have demonstrated the feasibility of T-cell receptor (TCR) gene transfer into T cells to circumvent self-tolerance to the widely expressed human p53 and MDM2 TAAs. (unimedizin-mainz.de)
The adoptive cellular immunotherapy with chimeric antigen receptor (CAR) immune cells, which involves modifying a patient's immune cells ex vivo with CARs that can recognize target antigens on tumour cells, is a promising approach. (academics.com)
Project 1: the role of PTPN22.6 in Intermediate Uveitis and Project 2: cord blood mononuclear cells as an alternative source for Chimeric Antigen Receptor-mediated cancer immunotherapy. (bham.ac.uk)
The development of novel T cell receptor - and chimeric antigen receptor - engineered T cell therapies for the treatment of cancer. (bham.ac.uk)
Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)
These include personalized anti-cancer vaccines (dendritic cell based) and chimeric antigen receptor (CAR)-T cell therapies for gastrointestinal and hepatobiliary cancers. (mayo.edu)
IL-2 and IFN-γ), immune checkpoint blockade (ICB) therapy (e.g., anti-PD-1/PD-L1 antibodies), and adoptive T-cell transfer (e.g., chimeric antigen receptor (CAR) T-cell therapy) [ 3 - 5 ]. (thno.org)
Infiltration, accumulation, and survival of chimeric antigen receptor T (CAR-T) cells in solid tumors is crucial for tumor clearance. (nature.com)
Redirecting therapeutic T cells against myelin-specific T lymphocytes using a humanized myelin basic protein-HLA-DR2-zeta chimeric receptor. (ox.ac.uk)
The receptor-modified therapeutic cells were active in vivo as well, eliminating Ag-specific T cells in a humanized mouse model system. (ox.ac.uk)
B). Upon antigen activation, CD8+ T cells upregulate the IL-10 receptor and IL-10. (baxkyardgardener.com)
Several types of ACT round out the immunotherapy arsenal, including chimeric antigen receptor (CAR) T-cell therapy, T-cell receptor (TCR) therapy, and tumor-infiltrating lymphocyte (TIL) therapy. (aacr.org)
Unfortunately, their clinical value is limited by their rapid loss of function and failure to expand in vivo, presumably due to the lack of costimulator molecules on tumor cells and the inherent limitations of signaling exclusively through the chimeric receptor. (nih.gov)
We now report that EBV-specific (but not primary) T cells transduced with tumor-specific chimeric receptor genes can be expanded and maintained long-term in the presence of EBV-infected B cells. (nih.gov)
γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)

The intracellular domains ensure intracellular signaling necessary to activate the effector functions of the CAR T cell. (medscape.com)
Dr. Nabil Ahmed is a physician-scientist engaged in translational research focusing on adoptive immunotherapy with gene-modified effector cells, to improve therapy for brain tumors. (texaschildrens.org)
This joint (Frankfurt/Mainz, Dresden, Essen, Heidelberg) translational immunotherapy project aims to combine NK cells as effector cells with universal epitope-specific CAR (UniCAR) with tunable activity. (unimedizin-mainz.de)
Accordingly, long-lived memory precursor effector T cells and antigen-specific T cells were increased by PD-1 blockade in intracranial lesions. (bvsalud.org)
The recruitment and role of effector and regulatory T cells in renal cell carcinoma. (bham.ac.uk)
Adoptive transfer of tumor antigen-specific stem cell memory T (T SCM ) cells is expected to overcome this shortcoming as T SCM cells are close to naïve T cells, but are also highly proliferative, long-lived, and produce a large number of effector T cells in response to antigen stimulation. (elsevierpure.com)
We previously reported that activated effector T cells can be converted into T SCM -like cells (iT SCM ) by coculturing with OP9 cells expressing Notch ligand, Delta-like 1 (OP9-hDLL1). (elsevierpure.com)
Regardless of the stimulation by anti-CD3/CD28 antibodies or by antigen-presenting cells, human iT SCM cells were more efficiently induced from central memory type T cells than from effector memory T cells. (elsevierpure.com)
Such memory T cells were traditionally defined as being comprised of both central memory (T CM ) and effector memory (T EM ) subsets ( 9 ). (frontiersin.org)
She had defined a mediating role for Myeloid-Derived Suppressor Cells and effector Natural Killer and T cells in the cancer recurrence and the development of postoperative metastases. (cancersummit.ca)
T cells must substantially increase nutrient uptake to mount a proper immune response and failure to obtain sufficient nutrients or engage the appropriate metabolic pathways can alter or prevent effector T cell differentiation and function. (elifesciences.org)

We also switched the adoptive immunotherapy for tumor-associated antigen-pulsed dendritic cell-activated killer (DAK) cell immunotherapy. (springeropen.com)
Of note, the TME is rich in immunosuppressive cells (e.g., tumor-associated macrophages (TAMs), regulatory T cells (Tregs), immature dendritic cells (iDCs) and myeloid-derived suppressor cells (MDSCs)), that can suppress antitumor immunity as a result of secretion of various cytokines and chemokines, which enables tumor escape from immune surveillance [ 8 ]. (thno.org)
Histopathological analyses showed increased infiltration of dendritic cells (DC) and T cells into tumor tissues following 7 × 19 CAR-T cell therapy. (nature.com)
Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. (nature.com)
TAA) on MifaMurtide MifaMurtide tumor cells or dendritic cells (DC) in the tumor. (baxkyardgardener.com)
Despite of various types of immunocyte in human body, the most frequent applied in current cancer immunotherapy is NK, Natural Killer Cells, the one and the only one specific cell, T cells and Dendritic Cells, DCs shows the best antigen presenting ability, etc. (safesavecell.com)
Dendritic cells originate in human hematopoietic stem cells within bones marrow, the differentiation process begins with the stem cells differentiate into bone marrow precursor cells, then mononuclear and eventually dendritic cells. (safesavecell.com)
Autologous Dendritic Cell/ Tumor Antigen" ADCTA cancer immunotherapy is a tailor made cancer treatment takes original autologous cancer antigens and immunocyte from the patient, ADCTA is exactly precise and suitable for every individual patient compared with chemotherapy or target therapeutic drugs which is designed based on a generic characters of cancer cells. (safesavecell.com)
One way in which biologists and medics use immunotherapy is by injecting antigen-incubated Dendritic Cells (DCs) into mice to stimulate an immune response. (mdpi.com)
Chen J, Wang S, Jia S, Ding G, Jiang G, Cao L. Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profile in Pancreatic Cancer Derived Exosomes Treated Dendritic Cells by Microarray Analysis. (jcancer.org)
Dendritic cells (DCs), which are the most potent antigen-presenting cells in the human body, play a pivotal role in the immune response. (jcancer.org)
The expression profiles of long noncoding RNAs (lncRNAs) and mRNAs of PEX-treated dendritic cells are unknown. (jcancer.org)

Genomic studies have provided insights into molecular subgroups and oncogenic drivers of pediatric brain tumors (PBT) that may lead to novel therapeutic strategies. (scielo.br)
Brain tumors are the most common solid tumor in pediatrics, accounting for 23.7% of new cancer diagnoses in children ( 1 1. (scielo.br)
Cacciotti C, Fleming A, Ramaswamy V. Advances in the molecular classification of pediatric brain tumors: a guide to the galaxy. (scielo.br)
Gamma deficits as a neural signature of cognitive impairment in children treated for brain tumors. (scielo.br)
7. Mabbott DJ, Snyder JJ, Penkman L, Witol A. The effects of treatment for posterior fossa brain tumors on selective attention. (scielo.br)
Dr Ahmed's initial studies demonstrated that antigen-specific cytotoxic T cells could eradicate established brain tumors in medulloblastoma and glioblastoma models. (texaschildrens.org)

A month after the second MCN, the patient's carcinoembryonic antigen (CEA) level had increased. (springeropen.com)
In approved products, a patient's own T lymphocytes are collected by apheresis and transduced with a gene that encodes for a CAR to direct the T cells against cancer cells. (medscape.com)
But the more we learn about cancer's molecular complexities and the immune system's response to tumors, the more it appears that we may need a precise combination of blows to defeat a patient's cancer permanently, with no need for a later rematch. (nih.gov)
Entering clinical development with our first adoptive cell therapy program is a significant step for Immatics, and highlights the ability of the XPRESIDENT platform to identify novel and true tumor antigens directly from a patient's tumor," said Harpreet Singh, PhD, chief scientific officer and CEO at Immatics US. (pharmacytimes.com)
The patient's newly engineered T cells will then be administered via the indwelling CNS catheter for two courses. (fredhutch.org)
Following the two courses, patient's will undergo a series of studies including MRI to evaluate the effect of the CAR T cells and may have the opportunity to continue receiving up to a total of six courses of CAR T cells if the patient has not had adverse effects and if more of their T cells are available. (fredhutch.org)
By isolating immature and immunosuppressive cells from a patient's blood, transforming them into potent immune-stimulatory cells in the laboratory, and then injecting them back directly into the patient's bloodstream or tumor, these novel therapies have the potential to induce long-term tumor-specific durable responses. (mayo.edu)
Immunotherapy emphases on strengthening the autoimmune system of a patient or obtaining the capability of immunity to prevent or cure patient's disease. (safesavecell.com)
This treatment utilizes a patient's own immune system to recognize and attack cancer cells. (aacr.org)
In contrast, ACT expands a patient's own T cells ex vivo to direct anti-tumor immunity when transfused back into the patient. (elifesciences.org)

Identifying the eight-gene signature ( CBX7 , JADE2 , IGF2BP3 , OR2W6P , PRAME , TICRR , KIF4A , and PIMREG ) could accurately identify patients' prognosis and the signature had close interactions with the immunodominant tumor environment, which may provide insight into personalized prognosis prediction and new therapies for PBT patients. (scielo.br)
Subsequent studies have demonstrated that the tumor-specific T cells, unlike conventional therapies, can effectively target the stem cell compartment in the tumor eradicating experimental tumors in animal models. (texaschildrens.org)
On average, the mice that received the triple-combination therapy (MEK inhibitor trametinib + BRAF inhibitor dabrafenib + immunotherapy, either anti-PD1 antibody or tumor antigen-specific adoptive cell transfer) lived at least twice as long as those that received the double-combination therapies. (nih.gov)
In the past decade, many clinical trials have been investigating anti-CTLA-4 as well as anti-programmed cell death protein 1 (PD-1) therapies in various solid tumors, including HCC. (stanford.edu)
We now need to know how we can improve the current immunotherapy strategies so that not only a subset of patients respond, but even more patients can benefit from these therapies," Sharma said. (aacr.org)
The recent success of T cell immune checkpoint inhibitor (ICI) therapies for cancer has revealed CD8 T cells as potent mediators of immunity against advanced cancers ( 4 , 5 ). (frontiersin.org)
However, many patients fail to respond to these therapies, and metabolic barriers imposed on T cells by the TME may contribute. (elifesciences.org)
Unfortunately, many patients still progress and acquire resistance to immunotherapy and molecularly targeted therapies. (biomedcentral.com)

Adoptive cellular therapy transmits the sensitized T cells to patients with low cellular immune function, which helps patients obtain antitumor immunity. (hindawi.com)
Among most immunosuppressive cells, TAMs, as crucial drivers of immunosuppressive TME, account for the largest proportion of immune cells in the TME (approximately 50% of tumor mass) [ 9 , 10 ], which possess highly heterogeneity and play a complex regulatory role in tumor immunity and immunotherapy due to helping tumor evade immune surveillance [ 11 ]. (thno.org)
IFN- induces antigen presentation and the development of CD8+ T cell immunity. (baxkyardgardener.com)
The way of Passive Immunity is to have patients receive allogeneic antibodies in order to inhibit the cancer cells metastasis or to kill the cancer cells. (safesavecell.com)
The active immunity is also known as cancer vaccine, divided into 3 categories as Tumor Cell Vaccine, Tumor Antigen Vaccine and Cell Antigen. (safesavecell.com)
It uses human's tumor debris, synthetic peptide drugs or applying the adoptive immunotherapy to increase the patients' immunity. (safesavecell.com)
Resident memory (T RM ) cells are a distinct tissue-localized T cell lineage that is crucial for protective immunity in peripheral tissues. (frontiersin.org)
While a great deal of effort has focused on defining their role in immunity to infections, studies now reveal T RM cells as a vital component of the host immune response to cancer. (frontiersin.org)
This review will recount the path to discovering the importance of resident memory CD8 T cells as they pertain to cancer immunity. (frontiersin.org)
In addition to highlighting key studies that directly implicate T RM cells in anti-tumor immunity, we will highlight earlier work that implicitly suggested their importance. (frontiersin.org)
These early classifications of T cell memory were quickly brought to bear on the question of what T cell subset provides the best immunity against cancer. (frontiersin.org)
Briefly, PBMC were subjected to a two-step culture, first synchronizing their exposure to the long peptides with aggressive surrogate activation of innate immunity, followed by IL-7-modulated T-cell hyperexpansion. (ndltd.org)

The genetically modified autologous T cells are expanded in vitro at a production facility and then reinfused into the patient. (medscape.com)
The clinical trial is the first to use products consisting of autologous cytotoxic T lymphocytes that target tumor antigens using Immatics' target warehouse, according to a press release. (pharmacytimes.com)
Patients with high risk or relapsed, NYESO-1 and/or LAGE-1 positive multiple myeloma (MM), are infused with 1-10x10 10 autologous TCR-engineered T cells 2 days after autologous stem cell transplantation (aSCT). (biomedcentral.com)
Immunotherapy based on the adoptive transfer of ex vivo expanded and activated autologous tumor-reactive lymphocytes can mediate tumor regression in cancer patients. (unimedizin-mainz.de)

Electron microscopy demonstrates specialized cell-cell junctions between keratinocytes and melanoma cells, and multielectrode array analysis shows that GABA acts to inhibit electrical activity in melanoma/keratinocyte cocultures. (bvsalud.org)
One cancer that provides us with a ringside seat on the powerful potential-and tough challenges-of targeted combination therapy is melanoma, especially the approximately 50% of advanced tumors with a specific "driver" mutation in the BRAF gene [1]. (nih.gov)
Drugs that target cells carrying BRAF mutations initially provided great hope for melanoma, with many reports of dramatic shrinkage of tumors in patients with advanced disease. (nih.gov)
In work that utilized a mouse model of advanced melanoma, UCLA physician-scientists Antoni Ribas, Siwen Hu-Lieskovan, and their colleagues found that when they added a drug that blocks a protein called MEK to a combo of a BRAF inhibitor plus immunotherapy, the mice's cancer was controlled more effectively, their immune responses were stronger, and they experienced fewer toxic side effects. (nih.gov)
We successfully applied this strategy to the human TAAs p53, gp100 and MDM2-specific TCRs as promising antigens-driven immunotherapy for both melanoma and hematologic malignancies. (unimedizin-mainz.de)
Focusing on advanced melanoma, we will investigate the antitumor activity of UniCAR NK cells in clinically relevant models. (unimedizin-mainz.de)
Recombinant targeting modules will be based on antibodies and soluble single-chain fragments of TCR specific for melanoma antigens. (unimedizin-mainz.de)
Pembrolizumab (Keytruda), a humanized monoclonal anti-PD-1 antibody, is the first anti-PD-1 antibody approved by the FDA for the treatment of patients with unresectable or metastatic melanoma, non-small-cell lung cancer (NSCLC), head and neck squamous cell carcinoma, cervical cancer, colorectal cancer, and gastric/gastroesophageal junction cancer [ 4 - 10 ]. (hindawi.com)
Reports of spontaneous regression and tumour infiltration with T-lymphocytes makes melanoma candidate for immunotherapies. (mdpi.com)

a Specimen with tumor-infiltrating lymphocytes. (springeropen.com)
Tumor Infiltrating Lymphocytes (TILs) are cytotoxic T-cells that are found in tumors. (shu.edu)
Most of them generally follow the same pathway to make immune-activated cytotoxic T lymphocytes (CTLs) abundantly infiltrate into tumor tissues and destroy tumor cells [ 6 ]. (thno.org)
Characterized by cell-surface molecules including CD103, CD69, and CD49a, T RM -like tumor-infiltrating lymphocytes (TILs) can be found in a wide range of human cancers, where they portend improved prognosis. (frontiersin.org)
This review will discuss the metabolic changes that drive T cells into different stages of their development and how the TME imposes barriers to the metabolism and activity of tumor infiltrating lymphocytes. (elifesciences.org)
Epstein-Barr virus (EBV) infection of B lymphocytes is near universal in humans and stimulates high levels of EBV-specific helper and cytotoxic T cells, which persist indefinitely. (nih.gov)
Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)

The emerging therapeutic approach of CAR-T cell therapy has sparked great interests, extensive studies in preclinical and clinical trials have revealed encouraging therapeutic efficacy in treating a variety of cancers, particularly in treating B-cell hematologic malignancies with CD19 CAR-T cells [ 3 ]. (ijbs.com)
Multidisciplinary approach including immunotherapy for such cancers has received much attention in recent years. (springeropen.com)
Importance: The protein p53 is an unequivocal tumor suppressor that is altered in half of all cancers. (stanford.edu)
IMA101 is a personalized investigational immunotherapy being evaluated for the treatment of multiple cancers, including ovarian, gastric, esophageal, non-small cell lung cancers, and head and neck squamous cell carcinoma. (pharmacytimes.com)
We made substantial progress in 2022 as we work to develop our novel arenaviral immunotherapies against a variety of cancers and infectious diseases. (financialcontent.com)
In January 2022, the first patient was dosed in the Phase 2 trial evaluating HB-200 in combination with pembrolizumab, as a potential treatment of 1st- and 2nd+-line advanced metastatic Human Papillomavirus 16 Positive (HPV16-positive) squamous cell head and neck cancers (HNSCC). (financialcontent.com)
In October 2022, HOOKIPA announced a strategic collaboration and license agreement to develop HB-700 for KRAS-mutated cancers and a second undisclosed novel immunotherapy candidate. (financialcontent.com)
In recent years, tumor immunotherapy has achieved significant success in various cancers and has been one of the hotspots in the life sciences, especially immune checkpoint inhibitors and adoptive cellular therapy [ 3 ]. (hindawi.com)
Immunotherapy is currently considered as a promising next-generation therapeutic strategy for various cancers thanks to its ability to modulate cell-specific immune responses toward tumors [ 1 ], which has gradually remodeled the landscape of clinical anticancer modality [ 2 ]. (thno.org)
Treatments, including radiation & immunotherapy, have proven to be effective in patients with metastatic solid cancers. (indiatimes.com)
In certain metastatic cancers, with radiation and immunotherapy, long term survival is possible. (indiatimes.com)
Collectively, these data support a role of CD4+ T cell derived IL-10 in the suppression of inflammation induced cancers. (baxkyardgardener.com)
Rosenberg is beginning to develop a library of TCRs that can recognize shared mutations in the hope of utilizing them for TCR T-cell therapy for patients across a variety of tumor types, especially those with common epithelial cancers. (aacr.org)
Dr O'Rourke reviews brain cancer vaccine trials at Penn Medicine, focusing on the EGFRvIII peptide vaccine, offers a synopsis of the application at Penn of adoptive T cell therapy to the brain cancers and considers GBM--surface antigens for CAR therapy in glioma. (pennmedicine.org)

Therapeutic response correlates with the mutational load of the patient tumors, suggesting that neoantigens contribute to tumor rejection. (unimedizin-mainz.de)
Tumor-specific neoantigens, which are expressed on tumor cells, can induce an effective antitumor cytotoxic T-cell response and mediate tumor regression. (wjgnet.com)
These strategies rely on the isolation of T cells, which are either genetically modified to target tumor-specific antigens or are expanded from an endogenous population that recognizes tumor neoantigens. (aacr.org)
neoantigens that elicit T-cell responses are identified as immunogenic. (aacr.org)
The recognition of antigens by immune cells is a crucial step in tumor-specific killing, and neoantigens generated by mutations in cancer cells possess high immunogenicity and are selectively expressed in tumor cells, making them an attractive therapeutic target. (techscience.com)

A major requirement for cancer immunotherapy is the development of biomarkers for prognosis and for monitoring therapy response. (oncotarget.com)
Secondary objectives include, feasibility, persistence of T-cells in vivo , and assessment of anti-cancer activity, and biomarkers. (pharmacytimes.com)
Immunotherapy biomarkers. (mayo.edu)
These immunotherapy biomarkers would ultimately help risk stratify patients and optimize the timing and design of combinatorial approaches. (mayo.edu)
This included sessions dedicated to systems biology on immunotherapy, immunogenicity and gene expression profiling, biomarkers, and combination treatment strategies. (biomedcentral.com)

Kochenderfer et al described dramatic regression of the lymphoma after infusion of CAR T cells engineered to target CD19. (medscape.com)
In mice, 7 × 19 CAR-T cells achieved complete regression of pre-established solid tumors and prolonged mouse survival, with superior anti-tumor activity compared to conventional CAR-T cells. (nature.com)
Figure 2: Complete regression of pre-established solid tumor by treatment with 7 × 19 CAR-T cells. (nature.com)
Tumor-specific T cells are identified, expanded, and infused into the lymphodepleted patient, where they can help mediate tumor regression. (aacr.org)
In a growing number of cases, CD8 T cells have been shown to mediate the regression of large bulky tumors, resulting in durable long-term disease remissions ( 5 ). (frontiersin.org)

Recent years, we have witnessed significant progresses in both basic and clinical studies regarding novel therapeutic strategies with genetically engineered T cells. (ijbs.com)
CAR-T cell therapy has achieved outstanding progresses in clinical observations, which makes it even more attractive in the development of cancer adoptive immunotherapy. (ijbs.com)
A controlled clinical crossover trial of exercise training to improve cognition and neural communication in pediatric brain tumor survivors. (scielo.br)
Several types of adoptive cell transfer are under investigation, but CAR T-cell therapy is the first to enter clinical practice. (medscape.com)
Immatics recently announced patient enrollment into a phase 1 clinical trial of its adoptive cellular therapy (ACT) IMA101, which uses its ACTolog approach. (pharmacytimes.com)
We report on a 26 patient phase I/II clinical trial (NCT01352286) to investigate the safety, feasibility and anti-tumor activity of T cells engineered to express an affinity-enhanced TCR that recognizes the NY-ESO-1/LAGE-1 peptide complex HLA-A*0201-SLLMWITQC. (biomedcentral.com)
Promising combinations of UniCAR NK cells and distinct targeting molecules will be identified for subsequent translation into a phase clinical study. (unimedizin-mainz.de)
Tumor immunotherapy brings substantial and long-term clinical benefits that can even cure tumors. (hindawi.com)
Dr. Kankeu Fonkoua collaborates with scientists and clinicians from various disciplines to conduct clinical trials and translational studies evaluating novel rational combinations to enhance anti-tumor immune response and improve clinical outcomes. (mayo.edu)
Clinical cancer immunotherapies are usually impeded by tumor immunosuppression driven by tumor associated macrophages (TAMs). (thno.org)
Thus, TAMs can be considered as a promising therapeutic target for improved immunotherapy, and TAMs-focused molecular targeting agents have made ideal progress in clinical practice. (thno.org)
Lastly, some severe challenges related to functional nanomedicines for TAMs-focused cancer immunotherapy are proposed, and some feasible perspectives on clinical translation of TAMs-associated anticancer immunonanomedicines are provided. (thno.org)
It is hoped that, with rapid development of nanomedicine in cancer immunotherapy, TAMs-focused therapeutic strategies may be anticipated to become an emerging immunotherapeutic modality for future clinical cancer treatment. (thno.org)
In clinical practice, cancer immunotherapies have been well developed in recent years, mainly including cytokine therapy (e.g. (thno.org)
Among tumor immunotherapies, neoantigen vaccines are in early human clinical trials and have demonstrated substantial efficiency. (wjgnet.com)
Our clinical studies have shown that EBV-specific T cells generated in vitro will expand, persist, and function for more than 6 years in vivo. (nih.gov)
However, the clinical application of tumor-infiltrating γδ T cells has certain limitations. (explorationpub.com)
Finally, it retrospectively analyze the activation strategies and clinical relevance of existing γδ T cell adoptive immunotherapies. (explorationpub.com)

abstract = "There is evidence showing that high avidity CTLs can be more effective than low avidity CTLs for adoptive tumor immunotherapy. (birmingham.ac.uk)
Abstract Ionizing radiation is frequently used to treat solid tumors, as it causes DNA damage and kill cancer cells. (techscience.com)
Abstract Scaffold proteins are crucial regulators of signaling networks, and their abnormal expression may favor the development of tumors. (techscience.com)
Abstract Neoantigen-targeted immunotherapy is a rapidly advancing field that holds great promise for treating cancer. (techscience.com)

Expanded understanding of the basic biology of T cell activation has enabled immunotherapy to combat cancer, and T cell metabolism now offers the opportunity to optimize and improve these therapeutic strategies. (elifesciences.org)

As this tumor suppressor is commonly inactivated in epithelioid sarcoma, cell division can fail to appropriately halt, resulting in unregulated cellular growth and the formation of cancer tumors. (wikipedia.org)
Oncogenes can initiate tumors only in certain cellular contexts, which is referred to as oncogenic competence. (bvsalud.org)
Defining cellular and subcellular structures in images, referred to as cell segmentation, is an outstanding obstacle to scalable single-cell analysis of multiplex imaging data. (bvsalud.org)
To address this unmet need, we release 105,774 primarily oncological cellular annotations concentrating on tumor and immune cells using over 40 antibody markers spanning three fluorescent imaging platforms, over a dozen tissue types and across various cellular morphologies. (bvsalud.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Previous work from the contributing DKTK partner sites has demonstrated the versatility of this approach in T cells, and showed that it is feasible to derive CAR-engineered, established human NK cells as an off-the-shelf cellular therapeutic. (unimedizin-mainz.de)
You will take advantage of machine learning methods for single-cell multi-omics in order to decipher disease pathogenesis in relation to treatment response and side effects of cellular immunotherapies. (academics.com)
Adoptive cellular immunotherapy. (mayo.edu)
In the small intestine of the same mice, overshooting severe inflammation prevented development of tumors at an early age, however progressive loss of IFN+ T cells and cellular cytotoxicity led to cancer development [37]. (baxkyardgardener.com)

In this study, we investigated whether high avidity MDM2-specific CTLs can mediate tumor protection without causing damage to normal tissues in mice. (birmingham.ac.uk)

And much work remains to be done to improve the efficacy of CAR-T cell therapy for solid tumors. (ijbs.com)
We therefore plan to administer both CAR-T cells to provide better cytotoxic coverage and increase efficacy. (bmj.com)
Cancer immunotherapy has demonstrated remarkable efficacy by checkpoint modulation in a large variety of neoplasms. (unimedizin-mainz.de)
We generated three retroviral CAR constructs based on huCD38 antibodies, CD3ζ and 4-1BB signaling domains and transduced them into T cells of healthy donors and MM patients to test the in vitro and in vivo efficacy. (biomedcentral.com)
These results signify the potential importance of CD38-CAR T cells as therapeutic tools for CD38 + malignancies, including MM, and warrant further safety and efficacy evaluation in appropriate models. (biomedcentral.com)
An approach that targets multiple essential processes of tumorigenesis can overcome tumor-associated plasticity, clonal evolution and adaptive resistance, all of which limit the durable efficacy of current treatments. (mayo.edu)
To the contrast, while the emerging immunotherapy focus on stimulating the immune system to awake the vital specific and active auto-immunocyte to be able to be targeting on attacking and destroying the remaining cancer cells after surgery to result a much better efficacy in longer life and living quality of a patient after receiving a radiotherapy or chemotherapy. (safesavecell.com)
These experiments suggest that induction of unresponsiveness may be an important mechanism limiting the efficacy of adoptive CTL therapy. (birmingham.ac.uk)
These findings indicate that a concise understanding of antigens and T cells in NSCLC is needed to improve therapeutic efficacy and reduce toxicity with immunotherapy, particularly adoptive T cell therapy. (researchwithrutgers.com)
According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)

Adoptive T-cell therapy is an effective strategy for cancer immunotherapy. (elsevierpure.com)
Thus, adoptive T-cell therapy with iT SCM offers a promising therapeutic strategy for cancer immunotherapy. (elsevierpure.com)

In this situation, immunotherapy could be a reliable candidate to improve the prognosis of these patients without lowering their quality of life. (springeropen.com)
50% of tumors contained high risk chromosomal abnormalities, and NY-ESO expression is correlated with adverse prognosis. (biomedcentral.com)
Intracranial metastases are common in nonsmall-cell lung cancer (NSCLC) patients, whose prognosis is very poor. (bvsalud.org)
It is a dose-limited factor of cancer immunotherapy and affects the prognosis and quality of life [ 15 ]. (hindawi.com)
However, infused T cells frequently become functionally exhausted, and consequently offer a poor prognosis after transplantation into patients. (elsevierpure.com)
To bypass resistance, combination treatment with immunotherapies and single or multiple TKIs have been shown to improve prognosis compared to monotherapy. (biomedcentral.com)

The CD38 molecule, with its high and homogenous expression on Multiple Myeloma (MM) cells, appears a suitable target for antibody therapy. (biomedcentral.com)

Dr. Kankeu Fonkoua's major research focus is understanding ways to integrate and exploit the synergy among therapeutic modalities to reprogram or boost the host's anti-tumor immune response. (mayo.edu)
thus, strategies to induce anti-tumor immune responses are needed. (ndltd.org)

Recent studies in mouse tumor models have shown that T RM cells are induced by cancer vaccines delivered in peripheral tissue sites, or by the depletion of regulatory T cells. (frontiersin.org)
This mechanistically rational antigen selection sequence, effective even for unvaccinated donors, regardless of HLA-haplotype, enables rapid identification of tumor protein regions relevant for cancer immunology, including adoptive immunotherapy, vaccines, and even identification of tumor neo-antigens unique to each patient. (ndltd.org)

Potential of arenaviral immunotherapies in novel combinations and against tumor self-antigens highlighted at AACR. (financialcontent.com)
In April 2022, HOOKIPA presented positive data at the 2022 American Association for Cancer Research Annual Meeting showing HOOKIPA's arenaviral immunotherapies induced potent T cell responses in novel combinations (such as co-stimulatory 4-1BB agonists or adoptive cell transfer) and against tumor self-antigens. (financialcontent.com)
T RM responses against tumor/self-antigens can concurrently result in the development of pathogenic T RM responses to self, with a growing number of autoimmune diseases and inflammatory pathologies being attributed to T RM responses. (frontiersin.org)

Natural killer (NK) cell-based immunotherapy may overcome genetic mechanisms of resistance to T cell-based immunotherapy through antigen- and MHC-independent recognition of malignant cells. (elifesciences.org)
it recognizes a specific protein on the surface of malignant cells (eg, CD19 on B-cells). (medscape.com)
They also lysed primary malignant cells from acute myeloid leukemia, and multi-drug resistant MM patients. (biomedcentral.com)
Cancer can be considered a disease of immune dysfunction, with a failure of immune recognition leading to the outgrowth of malignant cells as tumors ( 1 ). (frontiersin.org)

CAR-T cytotoxicity and activation was observed in vitro and in vivo resulting in decreased tumor burden (P≤0.001) and increased survival times (P≤0.001). (bmj.com)
However, analysis of the CTLs revealed that they had been rendered unresponsive in vivo because they did not produce interferon gamma in response to antigen-specific stimulation. (birmingham.ac.uk)

At present, the phenotypic heterogeneity and functional variation of human γδ T cells are increasing. (explorationpub.com)

Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). (researchwithrutgers.com)

However, targeting solid tumors is more challenging than targeting B-cell malignancies with CAR-T cells because of the histopathological structure features, specific antigens shortage and strong immunosuppressive environment of solid tumors. (ijbs.com)
The ACTolog approach targets tumor-specific antigens to fight cancer. (pharmacytimes.com)
It is personalized by measuring the presence of 8 tumor-specific antigens, according to the release. (pharmacytimes.com)

Alternating 2-vector therapy showed superior antigen-specific T cell responses, more robust anti-tumor activity and similar tolerability vs. single-vector therapy. (financialcontent.com)
An investigation of FcRL4 positive B cells in the rheumatoid synovium and The development of a cultured ELISPOT assay for the detection of low frequency t cell responses. (bham.ac.uk)
Following treatment of mice with 7 × 19 CAR-T cells, both recipient conventional T cells and administered CAR-T cells generated memory responses against tumors. (nature.com)
Informed by studies in infectious disease models, and instructed by a clear role for T RM cells in autoimmunity, we will discuss strategies for therapeutically promoting T RM responses in settings where they don't naturally occur. (frontiersin.org)
The persistence of such responses is fundamentally thought to be based on the ability of T cells to act as potent effectors and, subsequently, generate long-lived memory ( 6 ). (frontiersin.org)

NK cells can enhance T-cell activation without production of cytokines linked to adverse reactions. (unimedizin-mainz.de)
Moreover, TAMs usually display M2-like phenotypes that exert tumor-promoting role in TME, and promote production of related immunosuppressive factors that trigger immunotherapy resistance, including cytokines, chemokines, growth factors and soluble signaling mediators [ 12 ]. (thno.org)

Recent advances in cancer immunology, highlighted by immune checkpoint inhibitors, have demonstrated that immunotherapy is a viable option in the oncologist's armamentarium. (ndltd.org)

T cell-based immunotherapy, such as immune checkpoint blockade or adoptive T cell transfer, is limited by the ability of T cells to detect major histocompatibility complex (MHC)-presented antigen by tumor cells. (elifesciences.org)
Two of the primary immunotherapies are immune checkpoint blockade (ICB) and adoptive cell transfer (ACT). (elifesciences.org)

Three months later, when a recurrence-suspected lesion was detected in segment 5 (S5) of his liver, we started adoptive immunotherapies with cytokine-activated killer (CAK) cell infusions, combined with chemotherapy. (springeropen.com)
MBP-DR2-zeta-, but not MBP-DR2, modified CTL were specifically stimulated by cognate MBP-specific T cells, proliferating, producing cytokine, and killing the MBP-specific target cells. (ox.ac.uk)
In this scenario, regulatory T cells function both as a rate limiting producer of IL-10 and an essential recipient of the cytokine, and deficiency of IL-10 or the IL10R in Treg causes colitis [34]. (baxkyardgardener.com)
Th17 cells are functionally dependent on the myeloid-derived cytokine IL-23. (baxkyardgardener.com)
First, γδ T cells exposed to complicated cytokine networks are potentially affected by multiple inhibitory mechanisms. (explorationpub.com)

These data confirm the presence of tumor-specific TCR within the cancer tissue and suggest the existence of shared epitopes among different patients that might be used as targets for tumor immunotherapy. (oncotarget.com)
We hypothesized that many tumor associated antigens (Ag) are readily susceptible to immune attack, but only in the context of identifying the tumor antigen epitopes that can reliably initiate an immune response, regardless of individual patient human leukocyte antigen (HLA) haplotype restrictions. (ndltd.org)
We further hypothesized that epitope prediction strategies which seek to identify pan- or highly promiscuous-HLA binding epitopes would reduce the number of potential candidates and be more likely to accurately identify high-priority tumor Ag epitopes. (ndltd.org)
Predicted epitopes were synthesized in the form of synthetic long peptides and tested in immune system sensitization assays involving unfractionated peripheral blood mononuclear cells (PBMC). (ndltd.org)

Meanwhile, the on-target/off-tumor toxicity caused by relative expression of target on normal tissues is another issue that should be reckoned. (ijbs.com)
The T cells recovered from peripheral blood and spleens in patients and mice captured a limited portion of the TCR repertoire detected in tissues. (bvsalud.org)
These data demonstrate the complex composition of T cell populations that persist in human tissues at the end stage of an inflammatory disorder after lymphocyte-directed therapy. (bvsalud.org)
These findings also underscore the importance of studying T cell in tissues rather than blood for tissue-based pathologies and suggest the tissue-specific nature of both the endogenous and posttransplant T cell landscape. (bvsalud.org)
Secondary aims of the study will include to evaluate CAR T cell distribution with the cerebrospinal fluid (CSF), the extent to which CAR T cells egress or traffic into the peripheral circulation or blood stream, and, if tissues samples from multiple time points are available, also evaluate the degree of HER2 expression at diagnosis versus at recurrence. (fredhutch.org)
Figure 3: Infiltration of tumor tissues treated with 7 × 19 CAR-T cells by both T cells and DCs. (nature.com)
Following effective priming in lymph nodes, T cells traffic to tumors and other peripheral tissues. (frontiersin.org)
whereas T EM cells were shown to recirculate predominantly through blood, and peripheral tissues ( 10 ). (frontiersin.org)
In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
Although the CTLs prolonged survival of tumor-bearing mice without causing damage to normal tissues, tumor protection was incomplete. (birmingham.ac.uk)

Another thing that Drs. Ribas and Hu-Lieskovan found particularly encouraging was that, at least in mice, MEK inhibitors do not seem to impair the function of key immune cells called T cells. (nih.gov)
GPNMB knockout clones were generated in GL261 and engrafted in immunocompetent mice to examine single cell transcriptomes using sciRNAseq at endpoint. (bmj.com)
Ultimately a CD133+ population was observed in residual tumors of GPNMB treated mice at endpoint. (bmj.com)
High cleavage efficiency of a 2A peptide derived from porcine teschovirus-1 in human cell lines, zebrafish and mice. (nature.com)
Mice with a mutation in the adenomatous polyposis coli gene (APC468) develop intestinal tumors, driven by focal inflammation to their microbial gut flora. (baxkyardgardener.com)
Adoptive transfer of CD25hi T cells into MifaMurtide APC468 mice with colonic tumors lead to an IL-10Cdependent reduction of tumor burden [38]. (baxkyardgardener.com)
Epstein-Barr virus-specific iT SCM cells showed much stronger antitumor potentials than conventionally activated T cells in humanized Epstein-Barr virus transformed-tumor model mice. (elsevierpure.com)
We recently used the allo-restricted strategy to circumvent immunologic tolerance to a ubiquitously expressed tumor-associated protein, MDM2, and raised high avidity CTLs in humans and in mice. (birmingham.ac.uk)

A key area of Dr. Kankeu Fonkoua's research endeavors is to identify mechanisms of resistance to immunotherapy. (mayo.edu)

This is a critical pathway in angiogenesis, a process that cancer cells use to form new blood vessels, which provide necessary elements to the tumor for tumor survival. (wikipedia.org)
Eliminating GPNMB in cell lines decreased proliferation (P≤0.001) and prolonged survival times in all mouse models (P≤0.01) indicating its functional relevance. (bmj.com)
ADCTA is able to kill the remaining cancer cells to has a significant result of increasing Overall Survival, OS Rate while the conventional chemotherapy or radiotherapy is applied at the same time. (safesavecell.com)
Patients with higher T cell repertoire homology between the tumor and uninvolved tumor-adjacent lung, suggesting a less tumor-focused T cell response, exhibit inferior survival. (researchwithrutgers.com)

Immune checkpoint inhibitors (ICIs) are antibodies that target crucial signaling pathways, such as programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), to improve the activation of T cells and enhance the immune response to cancer cells. (hindawi.com)

About 13% of patients will present with multifocal tumors, and about 13% of patients will present with metastatic disease. (wikipedia.org)
PD-L1 CAR haNKs reduced levels of macrophages and other myeloid cells endogenously expressing high PD-L1 in peripheral blood from patients with head and neck cancer. (elifesciences.org)
Whereas few T cell clones were shared across patients, motif-based clustering revealed shared repertoire signatures across patients in a tissue-specific fashion. (bvsalud.org)
Due to the insidious identity of HCC, the majority of the patients are diagnosed at advanced stages, where tumor spreading, or distant metastasis unfortunately have already occurred. (stanford.edu)
Objective: This systemic review and meta-analysis focuses on the prognostic value of p53 Abs expressed in the serum of patients with solid tumors. (stanford.edu)
Main Outcome(s) and Measure(s): The primary study outcome was to determine the prognostic value of p53 Abs from a large population of patients with solid tumors, as determined before data collection. (stanford.edu)
Most of the RCC patients presented "patient-specific" TCR sequences, and those clonotypes were present at higher frequency in tumor lesions suggesting a specific extravasation from the blood. (oncotarget.com)
The primary objective of the new study is to assess the safety and tolerability of the ACTolog therapy in patients with target-positive solid tumors, according to the release. (pharmacytimes.com)
7 patients progressed after day 100, which was accompanied by loss of engineered T cells or loss of tumor antigen. (biomedcentral.com)
However, high-avidity T cells specific for tumor-associated antigens (TAAs) are usually absent in patients because of self-tolerance. (unimedizin-mainz.de)
Tumors from these patients will be used for peptide ligandome analyses, predictive in-situ biomarker analysis by immunohistochemistry, MALDI-TOF imaging mass spectrometry and RNA sequencing (RNAseq). (unimedizin-mainz.de)
This difference in tumor type could arise from your difference in the period of inflammation until tumor incidence, the anti-inflammatory medication in IL-10 deficient patients which may prevent the development of colon carcinomas in individual, or a notable difference in the microbiota that modifies the body organ specific cancer tumor risk. (baxkyardgardener.com)
This requires a better understanding of the T cells in the lungs of patients with NSCLC. (researchwithrutgers.com)
Here, we report T cell repertoire analysis in a cohort of 236 early-stage NSCLC patients. (researchwithrutgers.com)
eg, red blood cells [RBCs], platelets, plasma based on specific gravity) to use for transfusion in different patients. (msdmanuals.com)

In murine models, intracranial rechallenged tumors after initial rejection by PD-1 blockade were suppressed. (bvsalud.org)

In this review, we focus on the major obstacles limiting the application of CAR-T cell therapy toward solid tumors and summarize the measures to refine this new cancer therapeutic modality. (ijbs.com)
In this review, we discuss the current status and major obstacles for the treatment of solid tumors with CAR-T cells, thus provide some potential measures to refine this novel therapeutic modality. (ijbs.com)
Immunotherapy may be a promising modality among multidisciplinary methods for advanced cancer. (springeropen.com)

Because many T cell-recognized tumor antigens are nonmutated self-proteins, tolerance mechanisms are likely to render high avidity T cells unresponsive or cause T cell elimination by clonal deletion. (birmingham.ac.uk)
For example, exosomes and nanovesicles secreted by living cells serve as intercellular couriers of mRNA, microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and proteins and have thus garnered considerable interest [ 3 ]. (jcancer.org)
The growing list of human syndromes associated with the immunophilin defect underscores the biological relevance of these proteins that are largely opportunistically exploited by cancer cells to support and enable the tumor's intrinsic properties. (techscience.com)

We report here a rare case of a patient who has currently survived almost 10 years with recurrent GBC with peritoneal dissemination and liver metastases, which has been well controlled by a multidisciplinary approach including chemotherapy, immunotherapy, and surgery. (springeropen.com)
Among with 3 conventional treatments of surgery, radiotherapy and chemotherapy, the public worldwide has very high expectation ever since to consider the immunotherapy to be the 4th treatment on the list of options. (safesavecell.com)

Considerable research continues to enhance current efforts as well as extend this therapy to many tumor types. (medscape.com)
The first report of CAR T-cell therapy was in 2010, in a patient with advanced follicular lymphoma. (medscape.com)
The ACTolog technique also creates multiple cell therapy products to target each antigen, which may be more effective than targeting a single antigen, Immatics reported. (pharmacytimes.com)
The selection and creation of the ACTolog cell therapy drug is tailored for each patient, making the treatment precise. (pharmacytimes.com)
The third plenary session of the AACR Annual Meeting 2019 , titled "Manipulating the Immune System in Cancer Therapy," focused on recent advances in the field of immunotherapy. (aacr.org)
Unlike CAR T-cell therapy or TCR therapy, which modifies T cells taken from the blood, TIL therapy utilizes T cells that have infiltrated the tumor stroma, which requires a tumor biopsy. (aacr.org)

Treatment of syngeneic tumors resulted in CD8 and PD-L1-dependent tumor rejection or growth inhibition and a reduction in myeloid cells endogenously expressing high levels of PD-L1. (elifesciences.org)
Although CD38-CAR T cells lysed CD38 + monocytes, NK cells, CD34 + cells and to a lesser extent CD38 + T and B cells, they did not hamper the outgrowth progenitor cells into various myeloid lineages. (biomedcentral.com)
IL-17 attracts and activates granulocytes and myeloid cells promoting angiogenesis and Rabbit Polyclonal to AXL (phospho-Tyr691) wound repair. (baxkyardgardener.com)

The pro-inflammatory IL-23 also suppressed NK cell mediated tumor rejection [40]. (baxkyardgardener.com)

As the field of cancer immunotherapy advances rapidly, it is now crucial to understand how the dissemination and maintenance of tumor-specific T cells can be optimally achieved. (frontiersin.org)

SMARCB1 is a core protein subunit of the 15 subunit SWI/SNF (or BAF) complex involved in regulating the nucleosome architecture of our genome and has been shown to be a potent tumor suppressor gene, meaning that its primary role is to control cell division and to even halt division under appropriate circumstances (i.e. signals to over-replicate). (wikipedia.org)
Indeed a wealth of studies from humans and mouse models establishes a particularly potent role for CD8 T cells in controlling the outgrowth of malignancies ( 3 ). (frontiersin.org)

A considerable proportion of the most prevalent T cells in tumors are also prevalent in the uninvolved tumor-adjacent lungs and appear specific to shared background mutations or viral infections. (researchwithrutgers.com)

The ACTolog approach is based on the action of expanding specific endogenous T-cells and includes multiple innovative features, according to the release. (pharmacytimes.com)
A safety concern of TCR gene transfer is the risk of pairing between introduced and the naturally expressed endogenous TCR chains, resulting in the generation of self-reactive T cells. (unimedizin-mainz.de)
Hot spot" peptide Ag-specific T-cells preferentially recognized endogenous tumor derived MUC1, either in MUC1 expressing tumor cell killing assays (p=0.038, compared to non-peptide Ag-specific T-cells) or as MUC1 tumor lysate when pulsed onto restimulatory PBMC (p=0.022 and 0.025, for CD4+ and CD8+ T-cells, respectively, compared to T-cells directed against peptides from non-hot spot regions). (ndltd.org)

Preclinical development of adoptive T-cell immunotherapy for EBV-associated diseases using third-party donors. (bham.ac.uk)
Using surgically relevant preclinical animal models, Dr. Auer has identified candidate immunotherapies capable of counteracting the effects of surgery. (cancersummit.ca)

Tumor immunotherapy refers to novel therapeutic measures that turn the immune system into a destructive force against tumors [ 1 ]. (hindawi.com)

Anatomy24

Organisms10

Diseases47

Chemicals and Drugs68

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Phenomena and Processes32

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Health Care4

Microenvironment14

Receptors18

Receptor25

Effector11

Dendritic12

Brain tumors6

Patient's10

Therapies8

Immunity12

Autologous4

Melanoma9

Lymphocytes7

Cancers14

Neoantigens5

Biomarkers5

Regression5

Clinical18

Abstract4

Therapeutic strategies1

Cellular9

Mediate1

Efficacy10

Strategy for cancer immunotherapy2

Prognosis6

Antibody1

Anti-tumor immune2

Vaccines2

Self-antigens3

Malignant cells4

Vivo2

Heterogeneity1

Treat solid tumors1

Specific antigens3

Responses5

Cytokines2

Immunology1

Checkpoint blockade2

Cytokine5

Epitopes4

Tissues10

Mice8

Resistance to immunotherapy1

Survival4

Antibodies1

Patients15

Blockade1

Modality3

Proteins3

Chemotherapy2

Therapy6

Myeloid3

Rejection1

Advances1

Potent2

Viral1

Endogenous3

Preclinical2

Novel therapeutic1