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  • brain tumors
  • Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. (springer.com)
  • Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. (springer.com)
  • The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. (springer.com)
  • As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. (springer.com)
  • Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. (springer.com)
  • Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far. (springer.com)
  • Newswise - New research from the University of Adelaide has shown for the first time that the growth of brain tumors can be halted by a drug currently being used to help patients recover from the side effects of chemotherapy. (newswise.com)
  • So preventing the actions of substance P from carrying out its role in brain tumors actually halted the growth of brain cancer. (newswise.com)
  • The gene mutation occurs in the IDHI gene, which was first identified in human brain tumors called gliomas. (healthcentral.com)
  • tissue
  • ATCC has designed tumor cell panels based on the tissue of tumor origin, each annotated with details regarding known mutations - enabling more intelligent choices when selecting cell-based research models. (atcc.org)
  • When the factor's functioning was disrupted, the cancer cells moved much more effectively in what are known as three-dimensional matrix systems, which imitate some of the tissue properties of the human body. (biologynews.net)
  • Retinoids are molecules naturally produced by the human body, where they play a critical role in normal development by triggering primitive cells to become specialized cells characteristic of a particular tissue, such as nerve cells in the brain. (innovations-report.com)
  • Among the genes found to be switched on by retinoids was BMP-2 (bone morphogenetic protein-2), which codes for a protein thought to play a role in cell death and in the development of nervous system tissue that gives rise to medulloblastomas. (innovations-report.com)
  • In laboratory studies for her PhD, Dr Harford-Wright found that levels of substance P were greatly increased in brain tumor tissue. (newswise.com)
  • In normal breast tissue, around 8 cells cluster into spherical groups, each surrounded by a fibrous protein mesh. (newscientist.com)
  • But in cancerous breast tissue, in which the cells divide uncontrollably, this mesh is irregular and the cells clump together randomly. (newscientist.com)
  • It's name means that it is formed by small, round cancer cells surrounded by scar-like tissue. (dmoztools.net)
  • suppressor
  • Scientists at the Pharmacology Institute of the University of Heidelberg have discovered the previously unknown cell signal factor SCAI (suppressor of cancer cell invasion), which inhibits the movement and spread of tumor cells in laboratory tests. (biologynews.net)
  • Glioblastoma (GBM) is a malignant brain cancer that is often caused by mutations that result in the increased abundance or activity of epidermal growth factor receptors (EGFRs) or other receptor tyrosine kinases or by loss of the tumor suppressor protein PTEN (phosphatase tensin homolog deleted from chromosome 10). (sciencemag.org)
  • Loss of the tumor suppressor protein PML sensitizes glioblastoma cells to inhibitors of the mammalian target of rapamycin. (sciencemag.org)
  • Inhibition
  • Finally, analysis of GBM patient tumor samples before and after treatment with rapamycin showed the increased abundance of PML after mTOR inhibition. (sciencemag.org)
  • cervical
  • The overall conclusion therefore is that, as tumor cells can't stand the heat, the effectiveness of cervical cancer treatment can be boosted by hyperthermia. (uva.nl)
  • About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. (wikipedia.org)
  • In medical research, the most famous immortalised cell line, known as HeLa, was developed from cervical cancer cells of a woman named Henrietta Lacks. (wikipedia.org)
  • protein
  • Sera from three of eight vaccinated men contained new antibodies recognizing polypeptides of 26, 31, and 150 kDa in protein extracts from prostate cells. (aacrjournals.org)
  • The protein is apparently suppressed in many types of tumors, e.g. breast, lung, or thyroid," explains Dr. Robert Grosse, head of the Emmy Noether Junior Research Group funded by the German Research Association (DFG) at the Pharmacology Institute. (biologynews.net)
  • Through genome analysis, the scientists also identified a protein in medulloblastoma cells that is triggered by retinoids to initiate cell death, a finding that is likely to lead to the development of additional therapies for the disease. (innovations-report.com)
  • The addition of purified BMP-2 protein to medulloblastoma cells caused significant cell death, even to cells that were resistant to retinoids. (innovations-report.com)
  • An immunohistochemical analysis of tissues from GBM patients showed that 40% of patients had an increased abundance of PML (promyelocytic leukemia), a protein that is reduced in abundance in some tumors and increased in abundance in others. (sciencemag.org)
  • surgeries
  • the obvious benefits of avoiding the surgery include avoiding the risk related to the innate tumor-genicity of cancer surgeries. (wikipedia.org)
  • Hallahan and colleagues examined the effect of three retinoids on medulloblastoma tumor specimens obtained from surgeries. (innovations-report.com)
  • laboratory
  • This was a critical step because it was uncertain whether the available medulloblastoma cell lines (cells previously extracted from tumors and grown indefinitely in the laboratory) would accurately reflect the disease. (innovations-report.com)
  • Mina Bissell and Valerie Weaver of the Lawrence Berkeley National Laboratory in California and their colleagues made the discovery after looking at the way breast cells group together. (newscientist.com)
  • SRI's Brown Laboratory is using selected peptides as "fishing hooks" to identify novel cell surface features. (sri.com)
  • Terstappen
  • Those results were made possible by exquisitely sensitive magnetic separation technology employing ferrofluids (colloidal magnetic nanoparticles) and high gradient magnetic separators invented by Paul Liberti and motivated by theoretical calculations by Liberti and Leon Terstappen that indicated very small tumors shedding cells at less than 1.0% per day should result in detectable cells in blood. (wikipedia.org)
  • reduction
  • We were successful in blocking substance P from binding to the NK1 receptor, which resulted in a reduction in brain tumor growth - and it also caused cell death in the tumor cells," Dr Harford-Wright says. (newswise.com)
  • Once the tumors grew, the researchers injected them with the drug for 14 weeks and saw a dramatic reduction in tumor growth, and then what appeared to be a complete regression. (healthcentral.com)
  • Remarkably, addition of PARP1-inhibitors to hyperthermia and cisplatin, allows a ten-fold reduction of cisplatin dose, without decreasing tumor cell death. (uva.nl)
  • mutation
  • ATCC Tumor Cell Panels combine authenticated, well-characterized cell lines with mutation data from the Sanger Institute Catalogue of Somatic Mutations in Cancer (COSMIC) to create powerful tools for cancer research and drug discovery. (atcc.org)
  • ATCC has created gene mutation lists based on the ATCC tumor cell line collection and known mutation information maintained in the Sanger Institute COSMIC database. (atcc.org)
  • This mutation was found in 70 to 80 percent in lower-grade and progressive forms of this brain tumor. (healthcentral.com)
  • The mutation causes the IDHI gene - which regulates cell metabolism - to produce a flawed enzyme, which then produces large amounts of an entirely new molecule. (healthcentral.com)
  • aggressive
  • If the function of SCAI is confirmed to be decisive in the formation of especially aggressive tumor cells, this could be a promising starting point for developing new diagnostic methods or medication," says the pharmacologist. (biologynews.net)
  • gene
  • These data suggest that both T-cell and B-cell immune responses to human PCA can be generated by treatment with irradiated, GM-CSF gene-transduced PCA vaccines. (aacrjournals.org)
  • To identify genes responsible for the cell death, researchers looked at patterns of gene expression in medulloblastoma cells that were exposed to retinoids compared to untreated cells. (innovations-report.com)
  • treatments
  • This is a very exciting result, and it offers further opportunities to study possible brain tumor treatments over the coming years. (newswise.com)
  • Types
  • Researchers have known for some time that levels of substance P are also greatly increased in different tumor types around the body," says Dr Elizabeth Harford-Wright, a postdoctoral fellow in the University's Adelaide Centre for Neuroscience Research . (newswise.com)
  • Therapy
  • Standard therapy, which includes surgical removal of the tumor followed by radiation and a year of chemotherapy, offers about a 70 percent chance of survival for children over age 3 who do not have recurrent cancer. (innovations-report.com)
  • They stopped the therapy and, after seven weeks, the tumors had still not regrown. (healthcentral.com)
  • proteins
  • They then added an antibody to a receptor called beta-1 integrin, which allows cells to "communicate" chemically with the extracellular matrix, the gel of proteins between groups of cells. (newscientist.com)
  • The importance of these proteins for the formation of tumors was further confirmed in the fruit fly. (eurekalert.org)
  • enables
  • To help increase sensitivity while avoiding false negative results, AdnaTest enables highly specific tumor cell enrichment thanks to a combination of 3 different antibodies that bind to different epitopes or antigens. (qiagen.com)