DNA DamageCell Line, TumorCell CycleCell Cycle ProteinsGenes, cdcCheckpoint Kinase 2G2 PhaseCell Cycle CheckpointsProtein-Serine-Threonine KinasesMitosisAtaxia Telangiectasia Mutated ProteinsDNA RepairS PhaseProtein KinasesTumor Suppressor Protein p53DNA-Binding ProteinsHydroxyureaG2 Phase Cell Cycle CheckpointsTumor Suppressor ProteinsGamma RaysNuclear ProteinsSpindle ApparatusDNA ReplicationM Phase Cell Cycle CheckpointsG1 PhaseMutationUltraviolet RaysTumor Cells, CulturedApoptosisSaccharomyces cerevisiae ProteinsPhosphorylationSchizosaccharomycesMad2 ProteinsCell DivisionSchizosaccharomyces pombe ProteinsFungal ProteinsSaccharomyces cerevisiaeCell LineAtaxia TelangiectasiaSignal TransductionRadiation, Ionizingcdc25 PhosphatasesChromosomal InstabilityRadiation ToleranceCyclin-Dependent Kinase Inhibitor p21Molecular Sequence DataCyclinsGenomic InstabilityIntracellular Signaling Peptides and ProteinsCDC2 Protein KinaseCell ProliferationFlow CytometryCyclin BComet AssayDNA Breaks, Double-StrandedCell SurvivalGenes, FungalCells, CulturedHeLa CellsFibroblastsBase SequenceDNAModels, BiologicalNeoplasm ProteinsNeoplasmsHistonesG1 Phase Cell Cycle CheckpointsDNA, FungalGene DeletionTime FactorsS Phase Cell Cycle CheckpointsGene Expression Regulation, NeoplasticBRCA1 ProteinGenes, p53Mice, Inbred C57BLAntineoplastic AgentsPhenotypeRetinoblastoma ProteinRNA, Small InterferingCell NucleusCyclin B1Methyl MethanesulfonateAmino Acid SequenceNocodazoleRepressor ProteinsDNA Repair EnzymesDose-Response Relationship, RadiationProtein BindingBlotting, WesternTransfectionRNA, MessengerAneuploidyMutagensMice, KnockoutHCT116 CellsCyclin-Dependent Kinase 2Cell DeathTumor Markers, BiologicalNeoplasms, ExperimentalChromosomes, Fungal