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  • mice
  • As the population of target cells proceeded to various discrete phases of the cell cycle in a high degree of synchrony, these cells were challenged with normal macrophages or activated macrophages from Corynebacterium parvum -treated mice, and their subsequent ability to synthesize DNA and undergo mitosis was observed. (aacrjournals.org)
  • In one experiment, human T-ALL cells were infused into mice that then developed the disease. (medindia.net)
  • Blocking cyclin D1 in the mice drove the breast cancer cells into a kind of permanent retirement called senescence, an irreversible halt to their growth cycle. (medindia.net)
  • It was originally established as an ascites tumor in mice. (wikipedia.org)
  • Culture techniques in large-scale, mice passage is less attractive, due to the contamination of the tumor with multifarious host inflammatory cells. (wikipedia.org)
  • histone acetylation
  • These inactive HDAC1 mutants had a dominant-negative effect on regulating histone acetylation, suggesting a tumor-driving capacity of heterozygous inactivating HDAC1 mutations. (uva.nl)
  • growth
  • Determination of growth curves by direct enumeration of cells. (core.ac.uk)
  • Moreover, we showed that p16 inhibits breast cancer cell growth by inhibiting the VEGF signaling pathway and angiogenesis. (jcancer.org)
  • The outcomes of this study will help in optimizing the therapeutic application of 3-BP by targeting crucial tumor growth regulatory components of tumor milieu. (ovid.com)
  • The new results shown that the cancers' addiction to these proteins is an Achilles' heel that can be safely targeted with an inhibitor drug that halts cancer growth or causes cancer cells to die. (medindia.net)
  • High extracellular glutamine concentrations stimulate tumor growth and are essential for cell transformation. (wikipedia.org)
  • tumorigenesis
  • It is a member of the Poxviruses and Zinc-finger (POZ) and Krüppel (POK) family of proteins, and was identified in multiple screens involving either immune cell tumorigenesis or immune cell development. (wikipedia.org)
  • induce
  • T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. (wikipedia.org)
  • HeLa
  • cervix cancer HeLa) obtained with MTT-test and cell counts were performed using a tripan blue dye. (oalib.com)
  • In the present study we demonstrate a detectable cytostatic effect of the maleimide derivative MI1 on the epithelial cell lines Colo-205, MCF-7 and HeLa. (oalib.com)
  • Mikrokinematographische Analyse des Absterbens der HeLa-Zellen unter dem Einfluß des Inhibitors" [Microcinematographic analysis of the decay of HeLa cells under the influence of an inhibitory agent]. (wikipedia.org)
  • Morfologické zmeny HeLa buniek, vyvolané cytotoxickými koncentráciami izotiokyanátov" [Morphological changes of Hela cells induced by cytotoxic concentrations of isothiocyanates]. (wikipedia.org)
  • angiogenesis
  • Our previous study demonstrated that introduction of exogenous p16 via adenoviral gene transfer downregulated VEGF expression and inhibited angiogenesis in human BCa cells ( 17 ). (jcancer.org)
  • In search of an effective therapeutic strategy for improving colon cancer treatment, a novel role of miR-885-3p has been observed in tumor angiogenesis by targeting BMPR1A, which regulates a proangiogenic factor, and provide new evidence that targeting miRNAs might be an effective therapeutic strategy. (wikipedia.org)
  • murine
  • Systematic combination of Hdac1 and Hdac2 cKO alleles in murine thymi resulted in dosage-dependent tumor development of monoclonal lymphoblastic lymphomas, characterized by Myc-oncogene overexpression and a novel p53-suppressing mechanism. (uva.nl)
  • renal
  • MRT was initially described as an unfavorable histologic type of pediatric renal tumor, a variant of Wilms' tumor ( 1 ). (aacrjournals.org)
  • Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine. (wikipedia.org)
  • It is now known that this classic triad of symptoms only occurs in 10-15% of cases, and is usually indicative that the renal cell carcinoma (RCC) is in an advanced stage. (wikipedia.org)
  • Other genetically linked conditions also increase the risk of RCC, including hereditary papillary renal carcinoma, hereditary leiomyomatosis, Birt-Hogg-Dube syndrome, hyperparathyroidism-jaw tumor syndrome, familial papillary thyroid carcinoma, von Hippel-Lindau disease and sickle cell disease. (wikipedia.org)
  • The tumour arises from the cells of the proximal renal tubular epithelium. (wikipedia.org)
  • cancer
  • Global gene deregulations in FASN silenced retinoblastoma cancer cells: molecular and clinico-pathological correlations. (semanticscholar.org)
  • The aim of present study was to investigate influence of MI1 on the cell cycle of cancer cells and its cytotoxity. (oalib.com)
  • Here, we achieve the isolation and interrogation of individual CTC-associated WBCs, alongside with corresponding cancer cells within each CTC-WBC-cluster, from multiple breast cancer patients and mouse models. (omictools.com)
  • Single-cell RNA-Seq from CTCs and CTC-WBC-clusters obtained from multiple breast cancer patients and mouse models were used to identify CTC-associated WBCs cell types and differential expression between CTCs alone and CTC-associated to WBC. (omictools.com)
  • Cancer cell cycles. (semanticscholar.org)
  • To cycle or not to cycle: a critical decision in cancer. (semanticscholar.org)
  • The emerging data including ours indicated that p16 contributes its anti-cancer ability by inducing tumor cells to senescence. (jcancer.org)
  • In this study, we used adenoviral-mediated p16 expression (AdRSVp16) and breast cancer cell line MDA-MB-231 as the model to simultaneously analyze all these p16's anti-tumor functions. (jcancer.org)
  • therefore, this study justifies and promotes the viral-mediated p16 gene therapy as a promising and powerful treatment approach for cancer patients due to p16's multiple anti-tumor functions. (jcancer.org)
  • Even though the investigators genetically silenced the proteins or blocked them with a drug in normal as well as cancerous tissues, the animals remained healthy, they report in the Oct. 16 issue of the journal Cancer Cell . (medindia.net)
  • Many types of cancer have abnormal amounts of the proteins, spurring the cells to grow too rapidly and form tumors. (medindia.net)
  • In many types of cancer, an excess of cyclins allows cells to grow too fast and form tumors. (medindia.net)
  • In this paper, a model for the radiation treatment of cancer which includes the effects of the cell cycle is derived from first principles. (hindawi.com)
  • Conclusions: DPS selectively radioprotected normal intestinal CECs and sensitized prostate cancer cells in a clinically relevant model. (osti.gov)
  • Its geometrical isomer (Z)-ON 01910·Na has less cytotoxicity on cancer cells. (wikipedia.org)
  • RANKL derived from other cell types contributes to bone loss in conditions involving inflammation such as rheumatoid arthritis, and in lytic lesions caused by cancer, such as in multiple myeloma. (wikipedia.org)
  • mitotic
  • EMT-6 target cells were synchronized in the M phase by mitotic selection techniques and placed in culture. (aacrjournals.org)
  • 2. Estimation of the duration of each phase of the mitotic cycle based on incidence of cells in different phases. (core.ac.uk)
  • 3. Radioautographic studies to determine the proportion of cells in different phases of the mitotic cycle that incorporate tritiated thymidine during a single brief exposure to this precursor of DNA. (core.ac.uk)
  • The assumptions underlying these experiments and our observations concerning the duration of the period of DNA synthesis and its relation to the mitotic cycle are discussed. (core.ac.uk)
  • apoptotic
  • HMGB1 is considered to be late apoptotic marker and its release to the extracellular space seems to be required for the optimal release and presentation of tumour antigens to dendritic cells. (wikipedia.org)
  • survival
  • Despite significant advances in the treatment and outcome of other pediatric tumors, for MRTs diagnosed before the age of 6 months, patient survival at 4 years drops to ∼8.8% ( 4 ). (aacrjournals.org)
  • Further, the expression of cell survival regulatory molecules and hemodynamic characteristics of the tumor milieu were analysed to decipher mechanisms underlying the antitumor action of 3-BP. (ovid.com)
  • Further, 3-BP administration altered the expression of key regulatory molecules involved in glucose uptake, intracellular pH and tumor cell survival. (ovid.com)
  • mechanism
  • Gemcitabine progresses through a similar mechanism, causing cells in the S-phase to disrepair DNA damage caused by the radiation. (wikipedia.org)
  • Tangeretin strengthens the cell wall and acts as a plant's defensive mechanism against disease-causing pathogens. (wikipedia.org)
  • secretion
  • ICD is characterized by secretion of damage-associated molecular patterns (DAMPs).There are three most important DAMPs which are exposed to the cell surface during ICD. (wikipedia.org)
  • macrophages
  • Regardless of when normal macrophages were added, they had little effect on the target cells. (aacrjournals.org)
  • In contrast, target cells in the M or G 1 phase at the time of challenge with activated macrophages failed to undergo DNA synthesis (S phase), and their subsequent mitosis was inhibited. (aacrjournals.org)
  • When activated macrophages were added to EMT-6 cells synchronized in the late S or G 2 phase, many of the target cells failed to undergo the impending phase of mitosis. (aacrjournals.org)
  • Moreover, 3-BP reconstituted the external milieu, in concurrence with deregulated glucose and pH homeostasis and increased tumor infiltration by NK cells, macrophages, and T lymphocytes. (ovid.com)
  • chromosomal
  • The relationship between tumorigenicity and enhanced chromosomal radiosensitivity during the G 2 cell cycle phase was examined through the use of nontumorigenic human cell hybrids and their nontumorigenic and tumorigenic segregants. (aacrjournals.org)
  • The hybrids and their nontumorigenic subclones had cytological features which are predominantly found with a benign clinical course and had the G 2 chromosomal radiosensitivity more characteristic of the normal parental cells. (aacrjournals.org)
  • Like tumorigenic cells, fetal cells exhibited enhanced G 2 chromosomal radiosensitivity which could be suppressed in fetal × tumor cell hybrids. (aacrjournals.org)
  • immune
  • Pattern recognition receptors(PRRs), which can be grouped as endocytic PRRs or signaling PRRs, are expressed in all cells of the innate immune system. (wikipedia.org)
  • The release of both metabolites may protect tumor cells from immune attacks. (wikipedia.org)
  • RANKL also has a function in the immune system, where it is expressed by T helper cells and is thought to be involved in dendritic cell maturation. (wikipedia.org)
  • human
  • In human tumors, we identified somatic mutations catalytically inactivating HDAC1. (uva.nl)
  • dependent
  • The active-quiescent model is extended as a nonlinear birth-death process in order to derive an explicit time dependent expression for the tumour control probability (TCP). (hindawi.com)
  • On the other hand, tumor cells over express phosphate dependent glutaminase and NAD(P)-dependent malate decarboxylase, which in combination with the remaining reaction steps of the citric acid cycle from α-ketoglutarate to citrate impart the possibility of a new energy producing pathway, the degradation of the amino acid glutamine to glutamate, aspartate, pyruvate CO2, lactate and citrate. (wikipedia.org)
  • suppressor
  • While the pathway is very detailed and not completely understood, in general, when Wnt is not present, GSK-3B (a member of the pathway) is able to phosphorylate β-catenin as a result of a complex formation that includes β-catenin, AXIN1, AXIN2, APC (a tumor suppressor gene product), CSNK1A1, and GSK3B. (wikipedia.org)
  • tissue
  • In addition to the Warburg effect, glioblastoma tumor cells also utilize the tricarboxylic acid cycle/oxidative phosphorylation in a different capacity than normal tissue. (pitt.edu)
  • This study will also look at specific substances called biomarkers in your blood, and in the tumor tissue which are involved in the growth of tumor cells, and determine if the levels of these biomarkers are related to your response to treatment or development of side effects. (clinicaltrials.gov)
  • In addition, given the risks of using animal serum for tissue engineering, autologous blood may gain favor as a source of growth factors and serum supplements needed for stimulating cells to engineer intervertebral disc tissues. (blogspot.com)
  • Applications of phage display technology include determination of interaction partners of a protein (which would be used as the immobilised phage "bait" with a DNA library consisting of all coding sequences of a cell, tissue or organism) so that the function or the mechanism of the function of that protein may be determined. (wikipedia.org)
  • Gilmour continued her research at The Wistar Institute in Philadelphia, Pennsylvania, first as postdoctoral fellow (1984 to 1987) and then as research associate (1988 to 1990 While at Wistar, she began her work in characterizing the regulation and expression of ornithine decarboxylase (ODC) in both normal and tumor tissue. (wikipedia.org)
  • It is not detectable in non-proliferating normal tissue but is detectable in many human tumors. (wikipedia.org)
  • tissues
  • LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness. (nih.gov)
  • By doing so at the site of cancerous tissues in the body, L-DOS47 is believed to modify the microenvironmental conditions of lung cancer cells in a manner that leads to their death. (drugs.com)
  • In addition, the local production of ammonia at the site of cancerous tissues is thought to readily diffuse into the cancer cells to exert a potent cytotoxic effect by interfering with their critical metabolic functions. (drugs.com)
  • This deterioration is due to the death of the muscle cells and muscle tissues and leads to ongoing muscle wasting and muscle weakness. (blogspot.com)
  • Pasireotide works by binding to a protein called somatostatin receptor, which is expressed in many tissues throughout the body including thyroid cancer cells. (clinicaltrials.gov)
  • Mice lacking plakoglobin have cell adhesion defects in many tissues, although β-catenin substitutes for plakoglobin at many cellular junctions. (wikipedia.org)
  • The tumors cause fibrosis of tissues and impede digestion or organ function, and if left untreated, the tumors and mucin they produce will fill the abdominal cavity. (wikipedia.org)
  • cytotoxic
  • Tumors of mice treated with PBT showed reductions in myeloid cells that suppress immune attack on tumor cells and significant increases in tumor-specific cytotoxic T cells. (wikipedia.org)
  • It is a peptidase enhanced cytotoxic (PEnC) that exerts a targeted delivery of melphalan in cells with high expression of aminopeptidases, such as aminopeptidase N, which has been described as over-expressed in human malignancies. (wikipedia.org)
  • Melflufen is a peptidase enhanced cytotoxic (PEnC) with a targeted delivery within tumor cells of melphalan, a widely used classical chemotherapeutic belonging to a group of alkylating agents developed more than 50 years ago. (wikipedia.org)
  • gene
  • The phage gene and insert DNA hybrid is then inserted (a process known as "transduction") into Escherichia coli (E. coli) bacterial cells such as TG1, SS320, ER2738, or XL1-Blue E. coli. (wikipedia.org)
  • These gene products are important in determining cell fates during normal development and in maintaining homeostasis, or they can lead to de-regulated growth in disorders like cancer by responding to mutations in β-catenin, APC or Axin, each of which can lead to this de-regulated β-catenin level stabilization in cells. (wikipedia.org)
  • Although senescent cells can no longer replicate, they remain metabolically active and commonly adopt an immunogenic phenotype consisting of a pro-inflammatory secretome, the up-regulation of immune ligands, a pro-survival response, promiscuous gene expression (pGE) and stain positive for senescence-associated β-galactosidase activity. (wikipedia.org)
  • Mutations of the GLI2 gene are associated with several phenotypes including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. In human keratinocytes Gli2 activation upregulates a number of genes involved in cell cycle progression including E2F1, CCND1, CDC2 and CDC45L. (wikipedia.org)
  • adenocarcinoma
  • Dr. Chao will highlight previously announced laboratory and animal data that demonstrates the potential for L-DOS47 to bind to and debilitate and destroy human lung adenocarcinoma cells. (drugs.com)
  • Pseudomyxoma peritonei (PMP) is a clinical condition caused by cancerous cells (mucinous adenocarcinoma) that produce abundant mucin or gelatinous ascites. (wikipedia.org)
  • Cases of PMCA were characterized by peritoneal lesions composed of more abundant mucinous epithelium with the architectural and cytologic features of carcinoma (irregular cells, evidence that cells were rapidly dividing, and other criteria), with or without an associated primary mucinous adenocarcinoma. (wikipedia.org)
  • Odze and Goldblum, Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas, 2nd ed.) also use the term mucinous adenocarcinoma when referring to low-grade, well-differentiated tumors lacking high-grade features. (wikipedia.org)
  • cellular
  • Scientific discoveries: Gilmour's study of polyamines has broadened the scope of medical knowledge about tumor function at the cellular and molecular levels. (wikipedia.org)
  • Cellular senescence is the phenomenon by which normal diploid cells cease to divide. (wikipedia.org)
  • As such, cellular senescence represents a change in "cell state" rather than a cell becoming "aged" as the name confusingly suggests. (wikipedia.org)
  • Consistent with this, telomerase-immortalised cells continued to age (according to the epigenetic clock) without having been treated with any senescence inducers or DNA-damaging agents, re-affirming the independence of the process of epigenetic ageing from telomeres, cellular senescence, and the DNA damage response pathway. (wikipedia.org)
  • syndrome
  • Cardiac arrest Cytokine release syndrome Tumor lysis syndrome, causing acute renal failure Infections Hepatitis B reactivation Other viral infections Progressive multifocal leukoencephalopathy (PML) Immune toxicity, with depletion of B cells in 70% to 80% of lymphoma patients Pulmonary toxicity Bowel obstruction and perforation Two patients with systemic lupus erythematosus died of progressive multifocal leukoencephalopathy (PML) after being treated with rituximab. (wikipedia.org)
  • therapies
  • 3. The lab uses the genomic and metabolic information to build better representative brain tumor pre-clinical models for testing of novel therapies. (pitt.edu)
  • Once stratified, appropriate therapies can be applied allowing for personalized brain tumor therapy. (pitt.edu)
  • eukaryotic
  • The g1 phase, or Gap 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division. (wikipedia.org)
  • Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (wikipedia.org)
  • mitosis
  • Between the beginning of the G1 phase (which is also after mitosis has occurred) and R, the cell is known as being in the G1-pm subphase, or the post-mitotic phase. (wikipedia.org)
  • In this classification system, cases of DPAM were characterized by peritoneal lesions composed of abundant extracellular mucin containing scant simple to focally proliferative mucinous epithelium with little cytologic atypia or mitotic activity (in other words, most cells looked fairly normal and there was no evidence of mitosis which would indicate that cells were rapidly dividing), with or without an associated appendiceal mucinous adenoma. (wikipedia.org)
  • brain
  • The Brain Tumor Biology and Therapy Laboratory, under the direction of Sameer Agnihotri, PhD , studies pediatric and adult high-grade gliomas (HGG) and diffuse intrinsic pontine gliomas (DIPG). (pitt.edu)
  • The Agnihotri Laboratory investigates the metabolic dependencies of brain tumors and if they can provide therapeutic vulnerabilities. (pitt.edu)
  • Receptors
  • Adrenocorticotropic hormones bind to ACTH receptors on the cells within the adrenal medulla and adrenal cortex, causing a signal cascade within the adrenomedullary cell, ultimately releasing the neurotransmitter acetylcholine. (wikipedia.org)
  • fibroblasts
  • In culture, fibroblasts can reach a maximum of 50 cell divisions before becoming senescent. (wikipedia.org)
  • Dock11 is expressed at lower levels in NIH-3T3 fibroblasts, C2C12 myoblasts and Neuro-2A neuroblastoma cells. (wikipedia.org)
  • Citric
  • In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. (wikipedia.org)
  • The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. (wikipedia.org)
  • The IDH step of the citric acid cycle, due to its large negative free energy change, is one of the irreversible reactions in the citric acid cycle, and, therefore, must be carefully regulated to avoid unnecessary depletion of isocitrate (and therefore an accumulation of alpha-ketoglutarate). (wikipedia.org)
  • The reaction is stimulated by the simple mechanisms of substrate availability (isocitrate, NAD+ or NADP+, Mg2+ / Mn2+ ), product inhibition (by NADH (or NADPH outside the citric acid cycle) and alpha-ketoglutarate), and competitive feedback inhibition (by ATP). (wikipedia.org)
  • Within the citric acid cycle, isocitrate, produced from the isomerization of citrate, undergoes both oxidation and decarboxylation. (wikipedia.org)
  • Junctions
  • β-catenin acts by anchoring the actin cytoskeleton to the junctions, and may possibly aid in contact inhibition signaling within the cell. (wikipedia.org)
  • For instance, when an epithelial layer is complete and the adherens junctions indicate that the cell is surrounded, β-catenin may play a role in telling the cell to stop proliferating, as there is no room for more cells in the area. (wikipedia.org)
  • α-catenin participates in the formation and stabilization of adherens junctions by binding to β-catenin-cadherin complexes in the cell. (wikipedia.org)
  • triggers
  • Biochemical triggers known as cyclin-dependent kinases (Cdks) switch on cell cycles events at the corrected time and in the correct order to prevent any mistakes. (wikipedia.org)
  • telomere length
  • May play also an essential role in telomere length maintenance and telomere capping in mammalian cells. (abcam.cn)
  • Cells can also be induced to senesce via DNA damage in response to elevated reactive oxygen species (ROS), activation of oncogenes and cell-cell fusion, independent of telomere length. (wikipedia.org)
  • invasion
  • Bradley states that an adenoma, by definition, is a tumor confined to the appendiceal mucosa with absolutely no evidence of invasion beyond the muscularis mucosae. (wikipedia.org)
  • Causes
  • When inappropriately activated causes hair follicle derived tumors, the most clinically significant being the BCC. (wikipedia.org)
  • Neurons
  • Non-proliferative (non-dividing) cells in multicellular eukaryotes generally enter the quiescent G0 state from G1 and may remain quiescent for long periods of time, possibly indefinitely (as is often the case for neurons). (wikipedia.org)
  • Rituximab
  • Treatment of Children with Persistent and Chronic Idiopathic Thrombocytopenic Purpura: 4 Infusions of Rituximab and Three 4-Day Cycles of Dexamethasone. (nih.gov)
  • phase
  • Analyses of cell cycle distribution, and morphological microtubules organization showed that compound 3m induced G2/M phase arrest and, dramatically disrupted the microtubule network. (deepdyve.com)
  • The duration of each phase, including the G1 phase, is different in many different types of cells. (wikipedia.org)
  • In humans, the normal physiological temperature is around 37 °C (98.6 °F). G1 phase is particularly important in the cell cycle because it determines whether a cell commits to division or to leaving the cell cycle. (wikipedia.org)
  • If a cell is signaled to remain undivided, instead of moving onto the S phase, it will leave the G1 phase and move into a state of dormancy called the G0 phase. (wikipedia.org)
  • The restriction point (R) in the G1 phase is different from a checkpoint because it does not determine whether cell conditions are ideal to move on to the next phase, but it changes the course of the cell. (wikipedia.org)
  • After a vertebrate cell has been in the G1 phase for about three hours, the cell enters a restriction point in which it is decided whether the cell will move forward with the G1 phase or move into the dormant G0 phase. (wikipedia.org)
  • After R and before S, the cell is known as being in G1-ps, or the pre S phase interval of the G1 phase. (wikipedia.org)
  • M phase is itself composed of two tightly coupled processes: karyokinesis, in which the cell's chromosomes are divided, and cytokinesis, in which the cell's cytoplasm divides forming two daughter cells. (wikipedia.org)
  • Cells that have temporarily or reversibly stopped dividing are said to have entered a state of quiescence called G0 phase. (wikipedia.org)
  • G0 is a resting phase where the cell has left the cycle and has stopped dividing. (wikipedia.org)
  • The cell cycle starts with this phase. (wikipedia.org)
  • During this phase, the biosynthetic activities of the cell, which are considerably slowed down during M phase, resume at a high rate. (wikipedia.org)
  • In G1 phase, a cell has three options. (wikipedia.org)
  • expression
  • Over-expression of PPARδ also sensitised THP-1 cells to phorbol ester and correspondingly, inhibition of PPARδ by anti-sense RNA completely abolished this response. (biomedcentral.com)
  • activity
  • Melflufen was synthesized, partly due to previous experience of an alkylating peptide cocktail named Peptichemio and its anti-tumor activity is being investigated. (wikipedia.org)
  • fluorescence
  • Adjustments in the Ca2+ focus had been indicated as F/F, where F was the fluorescence strength when cells had been at rest, and F was the modification in fluorescence during excitement. (cancercurehere.com)
  • Development
  • However, loss of Gli3 leads to abnormal patterning and loss of Gli2 affects the development of ventral cell types, most significantly in the floor plate. (wikipedia.org)
  • disorders
  • However, more severe disorders of the sympathoadrenal system such as phaeochromocytoma (a tumor on the adrenal medulla) can affect the body's ability to maintain a homeostatic state. (wikipedia.org)
  • although
  • mucinous tumors of the ovary have also been implicated, although in most cases ovarian involvement is favored to be a metastasis from an appendiceal or other gastrointestinal source. (wikipedia.org)
  • complexes
  • Complexes of cyclin that are active during other phases of the cell cycle are kept inactivated to prevent any cell-cycle events from occurring out of order. (wikipedia.org)
  • Cell-cell adhesion complexes are required for simple epithelia in higher organisms to maintain structure, function and polarity. (wikipedia.org)
  • known
  • The modified plasmid of this bacterium used is known as Ti plasmid, or tumor inducing (Figure 2). (macalester.edu)
  • Within the cell cycle, there is a stringent set of regulations known as the cell cycle control system that controls the timing and coordination of the phases to ensure a correct order of events. (wikipedia.org)
  • therapy
  • Hematologic toxicity was common, but manageable with cycle prolongations, dose modifications and supportive therapy, and non-hematologic treatment-related adverse events were infrequent. (wikipedia.org)
  • stem
  • Gilmour provided the first evidence that elevated epidermal levels of polyamines alone can positively affect the recruitment of bulge stem cells in the skin. (wikipedia.org)