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  • inhibition
  • These results suggest that the inhibition of target cell DNA synthesis by activated macrophages is not a prerequisite for the ability of these effector cells to block target cell multiplication. (aacrjournals.org)
  • Lu Y, Zhang X, Zhang J. Inhibition of Breast Tumor Cell Growth by Ectopic Expression of p16/INK4A Via Combined Effects of Cell Cycle Arrest, Senescence and Apoptotic Induction, and Angiogenesis Inhibition. (jcancer.org)
  • Accumulated evidences have shown that senescence induction is linked to the p16's tumor inhibition. (jcancer.org)
  • In vivo dual inactivation of Hdac1 and Hdac2 in hematopoietic cells resulted in apoptosis of megakaryocytes with concomitant anemia and thrombocytopenia, suggesting that similar toxicities observed in patients treated with HDACi are caused by on-target inhibition. (uva.nl)
  • In tumor cells the citric acid cycle is truncated due to an inhibition of the enzyme aconitase (EC 4.2.1.3) by high concentrations of reactive oxygen species (ROS) Aconitase catalyzes the conversion of citrate to isocitrate. (wikipedia.org)
  • histone acetylation
  • These inactive HDAC1 mutants had a dominant-negative effect on regulating histone acetylation, suggesting a tumor-driving capacity of heterozygous inactivating HDAC1 mutations. (uva.nl)
  • tumorigenesis
  • It is a member of the Poxviruses and Zinc-finger (POZ) and Krüppel (POK) family of proteins, and was identified in multiple screens involving either immune cell tumorigenesis or immune cell development. (wikipedia.org)
  • induce
  • T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. (wikipedia.org)
  • HeLa
  • cervix cancer HeLa) obtained with MTT-test and cell counts were performed using a tripan blue dye. (oalib.com)
  • In the present study we demonstrate a detectable cytostatic effect of the maleimide derivative MI1 on the epithelial cell lines Colo-205, MCF-7 and HeLa. (oalib.com)
  • Mikrokinematographische Analyse des Absterbens der HeLa-Zellen unter dem Einfluß des Inhibitors" [Microcinematographic analysis of the decay of HeLa cells under the influence of an inhibitory agent]. (wikipedia.org)
  • Morfologické zmeny HeLa buniek, vyvolané cytotoxickými koncentráciami izotiokyanátov" [Morphological changes of Hela cells induced by cytotoxic concentrations of isothiocyanates]. (wikipedia.org)
  • angiogenesis
  • Moreover, we showed that p16 inhibits breast cancer cell growth by inhibiting the VEGF signaling pathway and angiogenesis. (jcancer.org)
  • Our previous study demonstrated that introduction of exogenous p16 via adenoviral gene transfer downregulated VEGF expression and inhibited angiogenesis in human BCa cells ( 17 ). (jcancer.org)
  • In search of an effective therapeutic strategy for improving colon cancer treatment, a novel role of miR-885-3p has been observed in tumor angiogenesis by targeting BMPR1A, which regulates a proangiogenic factor, and provide new evidence that targeting miRNAs might be an effective therapeutic strategy. (wikipedia.org)
  • murine
  • Systematic combination of Hdac1 and Hdac2 cKO alleles in murine thymi resulted in dosage-dependent tumor development of monoclonal lymphoblastic lymphomas, characterized by Myc-oncogene overexpression and a novel p53-suppressing mechanism. (uva.nl)
  • renal
  • MRT was initially described as an unfavorable histologic type of pediatric renal tumor, a variant of Wilms' tumor ( 1 ). (aacrjournals.org)
  • Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine. (wikipedia.org)
  • It is now known that this classic triad of symptoms only occurs in 10-15% of cases, and is usually indicative that the renal cell carcinoma (RCC) is in an advanced stage. (wikipedia.org)
  • Other genetically linked conditions also increase the risk of RCC, including hereditary papillary renal carcinoma, hereditary leiomyomatosis, Birt-Hogg-Dube syndrome, hyperparathyroidism-jaw tumor syndrome, familial papillary thyroid carcinoma, von Hippel-Lindau disease and sickle cell disease. (wikipedia.org)
  • The tumour arises from the cells of the proximal renal tubular epithelium. (wikipedia.org)
  • growth
  • Determination of growth curves by direct enumeration of cells. (core.ac.uk)
  • The outcomes of this study will help in optimizing the therapeutic application of 3-BP by targeting crucial tumor growth regulatory components of tumor milieu. (ovid.com)
  • The new results shown that the cancers' addiction to these proteins is an Achilles' heel that can be safely targeted with an inhibitor drug that halts cancer growth or causes cancer cells to die. (medindia.net)
  • High extracellular glutamine concentrations stimulate tumor growth and are essential for cell transformation. (wikipedia.org)
  • G1 phase together with the S phase and G2 phase comprise the long growth period of the cell cycle called interphase that takes place before cell division in mitosis (M phase). (wikipedia.org)
  • Once the required proteins and growth are complete, the cell enters the next phase of the cell cycle, S phase. (wikipedia.org)
  • G1 phase and the other subphases of the cell cycle may be affected by limiting growth factors such as nutrient supply, temperature, and room for growth. (wikipedia.org)
  • Physiological temperatures are optimal for cell growth. (wikipedia.org)
  • The first restriction point is growth-factor dependent and determines whether the cell moves into the G0 phase, while the second checkpoint is nutritionally-dependent and determines whether the cell moves into the S phase. (wikipedia.org)
  • Reasons the cell would not move into the S phase include insufficient cell growth, damaged DNA, or other preparations have not been completed. (wikipedia.org)
  • mitotic
  • EMT-6 target cells were synchronized in the M phase by mitotic selection techniques and placed in culture. (aacrjournals.org)
  • 2. Estimation of the duration of each phase of the mitotic cycle based on incidence of cells in different phases. (core.ac.uk)
  • 3. Radioautographic studies to determine the proportion of cells in different phases of the mitotic cycle that incorporate tritiated thymidine during a single brief exposure to this precursor of DNA. (core.ac.uk)
  • The assumptions underlying these experiments and our observations concerning the duration of the period of DNA synthesis and its relation to the mitotic cycle are discussed. (core.ac.uk)
  • Between the beginning of the G1 phase (which is also after mitosis has occurred) and R, the cell is known as being in the G1-pm subphase, or the post-mitotic phase. (wikipedia.org)
  • cancer
  • Global gene deregulations in FASN silenced retinoblastoma cancer cells: molecular and clinico-pathological correlations. (semanticscholar.org)
  • The aim of present study was to investigate influence of MI1 on the cell cycle of cancer cells and its cytotoxity. (oalib.com)
  • Cancer cell cycles. (semanticscholar.org)
  • To cycle or not to cycle: a critical decision in cancer. (semanticscholar.org)
  • The emerging data including ours indicated that p16 contributes its anti-cancer ability by inducing tumor cells to senescence. (jcancer.org)
  • In this study, we used adenoviral-mediated p16 expression (AdRSVp16) and breast cancer cell line MDA-MB-231 as the model to simultaneously analyze all these p16's anti-tumor functions. (jcancer.org)
  • therefore, this study justifies and promotes the viral-mediated p16 gene therapy as a promising and powerful treatment approach for cancer patients due to p16's multiple anti-tumor functions. (jcancer.org)
  • Even though the investigators genetically silenced the proteins or blocked them with a drug in normal as well as cancerous tissues, the animals remained healthy, they report in the Oct. 16 issue of the journal Cancer Cell . (medindia.net)
  • Many types of cancer have abnormal amounts of the proteins, spurring the cells to grow too rapidly and form tumors. (medindia.net)
  • In many types of cancer, an excess of cyclins allows cells to grow too fast and form tumors. (medindia.net)
  • In this paper, a model for the radiation treatment of cancer which includes the effects of the cell cycle is derived from first principles. (hindawi.com)
  • Conclusions: DPS selectively radioprotected normal intestinal CECs and sensitized prostate cancer cells in a clinically relevant model. (osti.gov)
  • Its geometrical isomer (Z)-ON 01910·Na has less cytotoxicity on cancer cells. (wikipedia.org)
  • RANKL derived from other cell types contributes to bone loss in conditions involving inflammation such as rheumatoid arthritis, and in lytic lesions caused by cancer, such as in multiple myeloma. (wikipedia.org)
  • apoptotic
  • HMGB1 is considered to be late apoptotic marker and its release to the extracellular space seems to be required for the optimal release and presentation of tumour antigens to dendritic cells. (wikipedia.org)
  • survival
  • Despite significant advances in the treatment and outcome of other pediatric tumors, for MRTs diagnosed before the age of 6 months, patient survival at 4 years drops to ∼8.8% ( 4 ). (aacrjournals.org)
  • Further, the expression of cell survival regulatory molecules and hemodynamic characteristics of the tumor milieu were analysed to decipher mechanisms underlying the antitumor action of 3-BP. (ovid.com)
  • Further, 3-BP administration altered the expression of key regulatory molecules involved in glucose uptake, intracellular pH and tumor cell survival. (ovid.com)
  • mechanism
  • Gemcitabine progresses through a similar mechanism, causing cells in the S-phase to disrepair DNA damage caused by the radiation. (wikipedia.org)
  • Tangeretin strengthens the cell wall and acts as a plant's defensive mechanism against disease-causing pathogens. (wikipedia.org)
  • dependent
  • The active-quiescent model is extended as a nonlinear birth-death process in order to derive an explicit time dependent expression for the tumour control probability (TCP). (hindawi.com)
  • On the other hand, tumor cells over express phosphate dependent glutaminase and NAD(P)-dependent malate decarboxylase, which in combination with the remaining reaction steps of the citric acid cycle from α-ketoglutarate to citrate impart the possibility of a new energy producing pathway, the degradation of the amino acid glutamine to glutamate, aspartate, pyruvate CO2, lactate and citrate. (wikipedia.org)
  • secretion
  • ICD is characterized by secretion of damage-associated molecular patterns (DAMPs).There are three most important DAMPs which are exposed to the cell surface during ICD. (wikipedia.org)
  • macrophages
  • Regardless of when normal macrophages were added, they had little effect on the target cells. (aacrjournals.org)
  • In contrast, target cells in the M or G 1 phase at the time of challenge with activated macrophages failed to undergo DNA synthesis (S phase), and their subsequent mitosis was inhibited. (aacrjournals.org)
  • When activated macrophages were added to EMT-6 cells synchronized in the late S or G 2 phase, many of the target cells failed to undergo the impending phase of mitosis. (aacrjournals.org)
  • Moreover, 3-BP reconstituted the external milieu, in concurrence with deregulated glucose and pH homeostasis and increased tumor infiltration by NK cells, macrophages, and T lymphocytes. (ovid.com)
  • proteins
  • In this part of interphase, the cell synthesizes mRNA and proteins in preparation for subsequent steps leading to mitosis. (wikipedia.org)
  • During G1 phase, the cell grows in size and synthesizes mRNA and proteins (Known as histones) that are required for DNA synthesis. (wikipedia.org)
  • chromosomal
  • The relationship between tumorigenicity and enhanced chromosomal radiosensitivity during the G 2 cell cycle phase was examined through the use of nontumorigenic human cell hybrids and their nontumorigenic and tumorigenic segregants. (aacrjournals.org)
  • The hybrids and their nontumorigenic subclones had cytological features which are predominantly found with a benign clinical course and had the G 2 chromosomal radiosensitivity more characteristic of the normal parental cells. (aacrjournals.org)
  • Like tumorigenic cells, fetal cells exhibited enhanced G 2 chromosomal radiosensitivity which could be suppressed in fetal × tumor cell hybrids. (aacrjournals.org)
  • immune
  • Pattern recognition receptors(PRRs), which can be grouped as endocytic PRRs or signaling PRRs, are expressed in all cells of the innate immune system. (wikipedia.org)
  • The release of both metabolites may protect tumor cells from immune attacks. (wikipedia.org)
  • RANKL also has a function in the immune system, where it is expressed by T helper cells and is thought to be involved in dendritic cell maturation. (wikipedia.org)