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  • nucleoli
  • This new method consists of sonicating cells in an isotonic medium containing MgSO(4), spermidine, and spermine, followed by separation of nucleoli through a Percoll density gradient. (ac.be)
  • biochemical
  • Therefore, family members who have up to a 50% lifetime risk of harboring a carcinoid tumor will undergo an intensive diagnostic evaluation using biochemical, endoscopic and imaging modalities at initial and subsequent two year follow up encounters. (clinicaltrials.gov)
  • carcinoids
  • In contrast to small-cell lung cancer and large-cell neuroendocrine lung tumours, TP53 and RB1 mutations are rare events, suggesting that pulmonary carcinoids are not early progenitor lesions of the highly aggressive lung neuroendocrine tumours but arise through independent cellular mechanisms. (semanticscholar.org)
  • gene
  • This study will evaluate members in families with a history of small bowel carcinoid cancer to study the natural history of those family members that have the disease, determine ways to improve early detection by performing surveillance on those at risk but without disease and to identify the gene(s) that may cause the tumors. (clinicaltrials.gov)
  • study
  • A comparative ultrastructural study of various cancerous cell lines using the Ag-NOR staining procedure. (ac.be)
  • primary tumor
  • Modern cancer research has demonstrated that CTCs derive from clones in the primary tumor, validating Ashworth's remarks. (wikipedia.org)
  • The powerful characterization by FASTcell™ CTC technology has been successfully used in a number of collaborative efforts including, in part, with City of Hope Cancer Center, to evaluate breast cancer heterogeneity relative to primary tumor biopsies, and with Stanford University School of Medicine, to examine biomarkers on CTCs for the evaluation of platinum-based therapy in non-small cell lung cancer. (sri.com)
  • Extragonadal germ cell tumors were thought initially to be isolated metastases from an undetected primary tumor in a gonad, but it is now known that many germ cell tumors are congenital and originate outside the gonads. (wikipedia.org)
  • cancers
  • These compounds work against neuroblastoma and other cancers because they trigger cells to differentiate (form specialized cells) and stop dividing," he said. (innovations-report.com)
  • Compared to germinomatous tumors, nongerminomatous tumors tend to grow faster, have an earlier mean age at time of diagnosis (~25 years versus ~35 years, in the case of testicular cancers), and have a lower 5 year survival rate. (wikipedia.org)
  • CTCs
  • CTCs constitute seeds for the subsequent growth of additional tumors ( metastases ) in distant organs, a mechanism that is responsible for the vast majority of cancer-related deaths. (wikipedia.org)
  • Furthermore, highly sensitive, single-cell analysis demonstrated a high level of heterogeneity seen at the single cell level for both protein expression and protein localization and the CTCs reflected both the primary biopsy and the changes seen in the metastatic sites. (wikipedia.org)
  • Apoptotic CTCs are traditional CTCs that are undergoing apoptosis (cell death): Epic Sciences technology identifies nuclear fragmentation or cytoplasmic blebbing associated with apoptosis. (wikipedia.org)
  • Measuring the ratio of traditional CTC to apoptotic CTCs - from baseline to therapy - provides clues to a therapy's efficacy in targeting and killing cancer cells. (wikipedia.org)
  • Small CTCs are cytokeratin positive and CD45 negative, but with sizes and shapes similar to white blood cells. (wikipedia.org)
  • CTCs thus constitute seeds for the subsequent growth of additional tumors (metastases) in vital distant organs, triggering a mechanism that is responsible for the vast majority of cancer-related deaths. (wikipedia.org)
  • Small CTCs have been implicated in progressive disease and differentiation into small cell carcinomas, which often require a different therapeutic course. (wikipedia.org)
  • SRI Biosciences' Center for Cancer and Metabolism offers its FASTcell™ Circulating Tumor Cell (CTC) technology as testing service to investigators for the detection and characterization of rare CTCs from whole blood samples. (sri.com)
  • FASTcell CTC technology's strength is its exquisite sensitivity and ability to detect and enumerate CTCs from a broad spectrum of tumor types. (sri.com)
  • However, detecting them against the background of normal cells in whole blood can be challenging, as it requires selective enrichment of CTCs or removal of other nucleated cells while maintaining the variability of tumor cell expression. (qiagen.com)
  • One challenge with detecting CTCs is separating out signals from white blood cells, which are similarly sized as tumor cells and can stick to the same antibodies normally used to identify tumor cells. (scienceblog.com)
  • Commercially available devices trap CTCs using antibody-coated magnetic beads, and technicians must stain the trapped cells with several antibodies to avoid falsely identifying white blood cells as tumor cells. (scienceblog.com)
  • It has emerged as a promising method for isolating circulation tumor cells (CTCs) from blood. (mdpi.com)
  • brain tumors
  • Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. (springer.com)
  • As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. (springer.com)
  • Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. (springer.com)
  • Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far. (springer.com)
  • Newswise - New research from the University of Adelaide has shown for the first time that the growth of brain tumors can be halted by a drug currently being used to help patients recover from the side effects of chemotherapy. (newswise.com)
  • So preventing the actions of substance P from carrying out its role in brain tumors actually halted the growth of brain cancer. (newswise.com)
  • small tumors
  • Those results were made possible by exquisitely sensitive magnetic separation technology employing ferrofluids (colloidal magnetic nanoparticles) and high gradient magnetic separators invented by Paul Liberti and motivated by theoretical calculations by Liberti and Leon Terstappen that indicated very small tumors shedding cells at less than 1.0% per day should result in detectable cells in blood. (wikipedia.org)
  • Patients with small tumors (usually asymptomatic) that appear resectable usually undergo thoracotomy and attempted complete resection followed by chemotherapy. (wikipedia.org)
  • clinical
  • Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases," Clinical Cancer Research , vol. 10, no. 20, pp. 6897-6904, 2004. (hindawi.com)
  • Clinical trials of the drugs, known as retinoids, are being planned for children who are at high risk for tumor relapse following standard therapy. (innovations-report.com)
  • More research should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer. (sciencemag.org)
  • Malignant mediastinal germ cell tumors of various histologies were first described as a clinical entity approximately 50 years ago. (wikipedia.org)
  • Other treatment options include: hematopoietic stem cell transplantation, intensity-modulated radiation Therapy, radiofrequency ablation, stereotactic body radiation therapy, intraperitoneal hyperthermic chemoperfusion, and clinical trials. (wikipedia.org)
  • This must be studied in order to improve clinical design strategy and select for patients with tumors that are more likely to benefit from anti-angiogenic drugs. (wikipedia.org)
  • typically
  • Granular cell tumors are typically solitary and are rarely larger than three centimeters. (wikipedia.org)
  • This tumor typically secretes renin, hence the former name of reninoma. (wikipedia.org)
  • Sertoli cell tumours typically present as a testicular mass or firmness, and their presence may be accompanied by gynaecomastia (25%) if they produce oestrogens, or precocious pseudopuberty in young boys, especially if they produce androgens. (wikipedia.org)
  • This can be done because the tumour is typically unifocal, not associated with precancerous lesions, and is unlikely to recur. (wikipedia.org)
  • They typically represent undifferentiated cells. (wikipedia.org)
  • These tumors are typically painless and can cause cortical erosion. (wikipedia.org)
  • Characterization
  • As part of its mission, ATCC will continue to augment the available information on the Tumor Cell Panel cell lines from other databases, and will perform further characterization on the panels. (prweb.com)
  • These methods allow the detection and characterization of early metastatic spread, provide unique insights into the biology of metastatic progression of human tumors and support the use of CTC blood tests as companion diagnostics and "liquid biopsy" in the context of therapeutic interventions. (mdpi.com)
  • Asymptomatic
  • If it is secreting androgens the tumour is usually asymptomatic, but can cause precocious puberty in pre-pubertal boys. (wikipedia.org)
  • Some patients may be asymptomatic until they develop a pathologic fracture at the site of the tumor. (wikipedia.org)
  • different tumor types
  • Researchers have known for some time that levels of substance P are also greatly increased in different tumor types around the body," says Dr Elizabeth Harford-Wright, a postdoctoral fellow in the University's Adelaide Centre for Neuroscience Research . (newswise.com)
  • Angiogenesis was originally introduced as a Hallmark of Cancer based on assumptions that the underlying processes were similar amongst different tumor types. (wikipedia.org)
  • testicular
  • Testicular Leydig cell tumours can be detected sonographically, ultrasound examinations may be ordered in the event of a palpable scrotal lump, however incidental identification of these lesions is also possible. (wikipedia.org)
  • The tumour is rare, comprising less than 1% of testicular tumours. (wikipedia.org)
  • patients
  • In a Phase I human gene therapy trial, eight immunocompetent prostate cancer (PCA) patients were treated with autologous, GM-CSF-secreting, irradiated tumor vaccines prepared from ex vivo retroviral transduction of surgically harvested cells. (aacrjournals.org)
  • T-cell responses, evaluated by assessing delayed-type hypersensitivity (DTH) reactions against untransduced autologous tumor cells, were evident in two of eight patients before vaccination and in seven of eight patients after treatment. (aacrjournals.org)
  • Detection of circulating tumour cells in peripheral blood of patients with advanced non-metastatic bladder cancer," BJU International , vol. 107, no. 10, pp. 1668-1675, 2011. (hindawi.com)
  • An immunohistochemical analysis of tissues from GBM patients showed that 40% of patients had an increased abundance of PML (promyelocytic leukemia), a protein that is reduced in abundance in some tumors and increased in abundance in others. (sciencemag.org)
  • A study led by Fred Hutchinson researchers, Drs. Andrew Hallahan and James Olson showed that retinoids killed cancer cells from medulloblastoma tumors that had been surgically removed from patients as well as tumors that had been grafted onto mice. (innovations-report.com)
  • Tiny gold particles can help doctors detect tumor cells circulating in the blood of patients with head and neck cancer, researchers at Emory and Georgia Tech have found. (scienceblog.com)
  • Many teams have focused on the development of sensitive assays that allow the specific detection of single tumor cells in the blood of cancer patients. (mdpi.com)
  • Due to excess testosterone secreted by the tumour, one-third of female patients present with a recent history of progressive masculinization. (wikipedia.org)
  • In most patients, the tumors are slow to develop, but may recur locally in as many as 50% of cases. (wikipedia.org)
  • Patients with tumors that are not amenable to surgery are treated with radiation therapy. (wikipedia.org)
  • However caution is employed since a majority of recurrent tumors with transformations to the malignant sarcoma phenotype have been in patients receiving radiotherapy for their primary benign lesion. (wikipedia.org)
  • Patients are often young and healthy as the tumors grow and spread uninhibited within the abdominal cavity. (wikipedia.org)
  • This is an aggressive, rare, fast spreading tumor and both pediatric and adult patients should be treated at a sarcoma center. (wikipedia.org)
  • cytoplasm
  • The predominance of blue staining is because the cells consist predominantly of nucleus, thus they have scant cytoplasm. (wikipedia.org)
  • PECs consist of perivascular epithelioid cells with a clear/granular cytoplasm and central round nucleus without prominent nucleoli. (wikipedia.org)
  • Leydig
  • Micrograph of a Leydig cell tumour. (wikipedia.org)
  • It arises from Leydig cells. (wikipedia.org)
  • The majority of Leydig cell tumors are found in males, usually at 5-10 years of age or in middle adulthood (30-60 years). (wikipedia.org)
  • Reinke crystals are classically found in these tumours and help confirm the diagnosis, although they are seen in less than half of all Leydig cell tumours. (wikipedia.org)
  • Immunohistochemical markers of Leydig cell tumours include inhibin-alpha, calretinin, and melan-A. The usual chemotherapy regimen has limited efficacy in tumours of this type, although Imatinib has shown some promise. (wikipedia.org)
  • Because in many cases Leydig cell tumour does not produce elevated tumour markers, the focus of surveillance is on repeated physical examination and imaging. (wikipedia.org)
  • tissue
  • ATCC has designed tumor cell panels based on the tissue of tumor origin, each annotated with details regarding known mutations - enabling more intelligent choices when selecting cell-based research models. (atcc.org)
  • When the factor's functioning was disrupted, the cancer cells moved much more effectively in what are known as three-dimensional matrix systems, which imitate some of the tissue properties of the human body. (biologynews.net)
  • Retinoids are molecules naturally produced by the human body, where they play a critical role in normal development by triggering primitive cells to become specialized cells characteristic of a particular tissue, such as nerve cells in the brain. (innovations-report.com)
  • Among the genes found to be switched on by retinoids was BMP-2 (bone morphogenetic protein-2), which codes for a protein thought to play a role in cell death and in the development of nervous system tissue that gives rise to medulloblastomas. (innovations-report.com)
  • To enable cancer researchers, ATCC (American Type Culture Collection) has introduced a collection of Tissue-Specific Tumor Cell Panels. (prweb.com)
  • Each Tissue-Specific Tumor Cell Panel is comprised of different cell lines that have been grouped by tissue of tumor origin. (prweb.com)
  • ATCC Tissue-Specific Tumor Cell panels offer economy over individual lines, are supplied with comprehensive genetic profile information, and are accompanied by expert support if needed. (prweb.com)
  • In laboratory studies for her PhD, Dr Harford-Wright found that levels of substance P were greatly increased in brain tumor tissue. (newswise.com)
  • Granular cell tumors show similarity to neural tissue, as can be demonstrated by immunohistochemistry and ultrastructural evidence using electron microscopy. (wikipedia.org)
  • Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. (wikipedia.org)
  • The tumor is classified as a soft tissue sarcoma. (wikipedia.org)
  • Play media Tumor-associated endothelial cells or tumor endothelial cells (TECs) refers to cells lining the tumor-associated blood vessels that control the passage of nutrients into surrounding tumor tissue. (wikipedia.org)
  • It's name means that it is formed by small, round cancer cells surrounded by scar-like tissue. (dmoztools.net)
  • metastatic
  • Present tumor staging is mainly based on local tumor extension, metastatic lymph node involvement and evidence of overt distant metastasis obtained by imaging technologies. (mdpi.com)
  • However, these staging procedures are not sensitive enough to detect minute amounts of metastatic cells. (mdpi.com)
  • progression
  • Treatment of GBM cells and a GBM-derived cell line in culture with either rapamycin or the EGFR inhibitor erlotinib led to the increased abundance of PML, and overexpression studies in cultured cells showed that increased PML abundance decreased PI3K-mTOR signaling and delayed progression through the cell cycle. (sciencemag.org)
  • Across different cancer types, tumor-associated blood vessels have been discovered to differ significantly from normal blood vessels in morphology, gene expression, and functionality in ways that promote cancer progression. (wikipedia.org)
  • Sorafenib and sutinib are additional angiogenesis inhibitors that bind and block receptors on endothelial cells that have important roles in downstream pathways contributing to angiogenesis progression. (wikipedia.org)
  • local tumor
  • Excision can be extralesional which achieves 90% local tumor control but poor functional outcome or it can be intralesional which has 90% local recurrence rate with good functional outcome. (wikipedia.org)
  • tumours
  • T. R. Ashworth, "A case of cancer in which cells similar to those in the tumours were seen in the blood after death," Australasian Medical Journal , vol. 14, pp. 146-147, 1869. (hindawi.com)
  • Granulosa cell tumours (or granulosa-theca cell tumours or folliculoma) are tumours that arise from granulosa cells. (wikipedia.org)
  • these tumors tend to have late recurrencies ( even after 30 years ) Using next generation DNA sequencing, it was discovered that 97% of granulosa cell tumours contain an identical mutation in the FOXL2 gene . (wikipedia.org)
  • It is believed that this mutation may be the cause of granulosa cell tumours. (wikipedia.org)
  • Perivascular epithelioid cell tumour, also known as PEComa or PEC tumour, is a family of mesenchymal tumours consisting of perivascular epithelioid cells (PECs). (wikipedia.org)
  • The cell type from which these tumours originate remains unknown. (wikipedia.org)
  • sarcoma
  • Although classified as a benign tumor, GCTOB has been observed to metastesize to the lungs in up to 5% of cases, and in rare instances (1-3%) can transform to the malignant sarcoma phenotype with equal disease outcome. (wikipedia.org)
  • abdominopelvic sarcoma of perivascular epitheloid cells primary extrapulmonary sugar tumour Thus, it has been advocated that the above could be classified PEComas. (wikipedia.org)
  • The conservative treatment of giant cell sarcoma, with the study of bone transplantation. (wikipedia.org)
  • apoptosis
  • Knockdown of PML in GBM cell lines by small-interfering RNA (siRNA) increased the sensitivity of the cells to the induction of apoptosis by mTOR and EGFR inhibitors. (sciencemag.org)
  • Treatment of GBM cells with arsenic trioxide, a therapeutic agent that targets PML for proteasomal degradation, blocked the enhanced production of PML in response to an mTOR inhibitor and sensitized the cells to apoptosis. (sciencemag.org)
  • Pharmacotherapy for GCTOB, includes bisphosphonates such as Zoledronate, which are thought to induce apoptosis in the MNGC fraction, preventing tumor-induced osteolysis. (wikipedia.org)
  • cancer
  • Irradiated GM-CSF-secreting cancer cell vaccines induce antitumor immune responses by recruiting antigen-presenting cells, such as DCs, to immunization sites. (aacrjournals.org)
  • the obvious benefits of avoiding the surgery include avoiding the risk related to the innate tumor-genicity of cancer surgeries. (wikipedia.org)
  • An autologous tumor cell is a cancer cell from an individual's own tumor. (wikipedia.org)
  • Prognostic value of circulating tumor cellsin nonmuscle invasive bladder cancer: a cell search analysis," Annals of Oncology , vol. 23, no. 9, Article ID mdr619, pp. 2352-2356, 2012. (hindawi.com)
  • Detection of circulating urothelial cancer cells in the blood using the CellSearch system," Cancer , vol. 109, no. 7, pp. 1439-1445, 2007. (hindawi.com)
  • Glioblastoma (GBM) is a malignant brain cancer that is often caused by mutations that result in the increased abundance or activity of epidermal growth factor receptors (EGFRs) or other receptor tyrosine kinases or by loss of the tumor suppressor protein PTEN (phosphatase tensin homolog deleted from chromosome 10). (sciencemag.org)
  • Scientists at the Pharmacology Institute of the University of Heidelberg have discovered the previously unknown cell signal factor SCAI (suppressor of cancer cell invasion), which inhibits the movement and spread of tumor cells in laboratory tests. (biologynews.net)
  • One of these receptors is what is known as b1-integrin, which is frequently formed in many tumors such as metastasizing breast cancer. (biologynews.net)
  • In their recently published study, the Heidelberg researchers examined cells from skin cancer (melanoma) and breast cancer. (biologynews.net)
  • It could also be possible to develop an agent that prevents the genetic suppression of the signal factor in cancer cells. (biologynews.net)
  • But we observed that when the compounds are applied to medulloblastoma tumors, a large percentage of cancer cells actually die. (innovations-report.com)
  • Scientists also have created synthetic retinoids, which have proved to be effective against some tumors because they drive cancer cells from their relatively primitive, undifferentiated state into specialized cells that cease to divide. (innovations-report.com)
  • When combined with the size and scope of the ATCC tumor cell line collection, this growing knowledge base enables scientists to make smarter choices when selecting cell-based research models for cancer research, drug discovery, compound screening, biomarker selection, pathway analysis and functional genomics. (prweb.com)
  • Scientists are requiring more genomic and proteomic data on the cell lines they use in their studies to understand the roles that genetic defects have in the pathobiology of cancer," said Dr. Richard Kolodner, Member, Ludwig Institute for Cancer Research, UC San Diego School of Medicine Branch. (prweb.com)
  • The tumor appears to arise from the primitive cells of childhood, and is considered a childhood cancer. (wikipedia.org)
  • There has been notable interest in developing cancer therapeutics that capitalize on these abnormalities of the tumor-associated endothelium to destroy tumors. (wikipedia.org)
  • However, there are now multiple studies that illustrate the complexity behind these previous simple conceptions of angiogenesis, indicating that the way cancer cells interact with and co-opt new blood vessel growth varies amongst cancer types and must be studied. (wikipedia.org)
  • Detection
  • Since it enables the simultaneous detection of various tumor-specific biomarkers in a multiplexed fashion, it can address the very real problem of tumor heterogeneity. (sri.com)
  • neoplastic
  • The immunophenotype is rather characteristic, as the neoplastic cells express renin, CD34, smooth muscle actin, CD138, vimentin, collagen IV and is negative for cytokeratins as well as for S100, c-Kit and desmin. (wikipedia.org)
  • In contrast, the mononuclear histiocytic cells (MNHC) and multinucleated giant cell (MNGC) fractions are secondarily recruited and comprise the non-neoplastic cell population. (wikipedia.org)
  • aggressive
  • If the function of SCAI is confirmed to be decisive in the formation of especially aggressive tumor cells, this could be a promising starting point for developing new diagnostic methods or medication," says the pharmacologist. (biologynews.net)
  • abnormalities
  • Working closely with customers, ATCC scientists have identified cell lines that that are easy to grow using standard media formulations and possess critical genetic abnormalities found in tumors. (prweb.com)
  • DSRCT
  • DSRCT is associated with a unique chromosomal translocation t(11;22)(p13:q12) resulting in an EWS/WT1 transcript that is diagnostic of this tumor. (wikipedia.org)
  • molecular
  • It offers highly specific immunomagnetic cell selection and highly sensitive RT-PCR technology to support in-depth investigations of CTC characteristics and molecular signal transduction pathways in all major tumor entities. (qiagen.com)
  • Loss of pericyte growth factor (PDGFB) and its receptor on endothelial cells are molecular-level changes that can account for this abnormal loss in pericyte support. (wikipedia.org)
  • transgenic mouse
  • Specially M Wnt cells, cloned from a spontaneous mammary tumor from a MMTV Wnt 1 transgenic mouse, ow a senchy mal morphology, stably convey stem cell markers Manti Te'o Chargers Jersey , and swiftly create claudin reduced maArlen Booth s Cocaine Coma provides an important social mentary, exploring many societal problems while grounding itself in a story of an ordinary, middle class Chicago family to which anyone could relate. (xobor.com)
  • pathway
  • The activation of the c-Src pathway has been observed in about 50% of tumors from colon, liver, lung, breast and the pancreas. (wikipedia.org)
  • When a tumor blocks the pathway of the cerebrospinal fluid, this will cause headaches in the patient. (wikipedia.org)
  • Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (wikipedia.org)
  • As a result, the ErbB2/ErbB3 signaling pathway becomes constitutively activated, cell-cell interactions are lost and signet carcinomas are formed. (wikipedia.org)
  • While the pathway is very detailed and not completely understood, in general, when Wnt is not present, GSK-3B (a member of the pathway) is able to phosphorylate β-catenin as a result of a complex formation that includes β-catenin, AXIN1, AXIN2, APC (a tumor suppressor gene product), CSNK1A1, and GSK3B. (wikipedia.org)
  • mucosal
  • Mastoiditis is inflammation of the mastoid air cells, air-filled mucosal lined spaces within the temporal bone. (neurologyadvisor.com)
  • The mastoid air cell system is in functional and anatomic continuity with the middle ear, and inflammation of the middle ear is often associated with mastoid fluid or mucosal inflammation. (neurologyadvisor.com)
  • Background: Endoscopic mucosal resection is widely used for treating rectal carcinoid tumors. (omicsonline.org)
  • We use endoscopic mucosal resection after circumferential mucosal incision, which is performed after mucosal resection around the lesion to treat rectal carcinoid tumors. (omicsonline.org)
  • Patients: We retrospectively studied 6 patients with rectal carcinoid tumors ≤ 10 mm treated by endoscopic mucosal resection after circumferential mucosal incision, between August 2010 and December 2012 at Shiga University of Medical Science. (omicsonline.org)
  • Conclusions: Endoscopic mucosal resection after circumferential mucosal incision was effective for treating ≤ 10-mm-diameter rectal carcinoid tumors. (omicsonline.org)
  • aberrant
  • One more rising problem is that Kendall Reyes Chargers Jersey , in addition to im pting the advancent and survival of aberrant cells, CR and mTOR inhibition may well also impt the stem mobile partnt and enrich maintenance or fix of tissues. (xobor.com)
  • Biology
  • The Brain Tumor Biology and Therapy Laboratory, under the direction of Sameer Agnihotri, PhD , studies pediatric and adult high-grade gliomas (HGG) and diffuse intrinsic pontine gliomas (DIPG). (pitt.edu)
  • One study suggests that its dismal prognosis seems to be caused by its intrinsic tumor biology, suggesting an area for further research. (wikipedia.org)
  • Targeting
  • The technique is also used to determine tumour antigens (for use in diagnosis and therapeutic targeting) and in searching for protein-DNA interactions using specially-constructed DNA libraries with randomised segments. (wikipedia.org)
  • bone
  • Febrile neutropenia can develop in any form of neutropenia, but is most generally recognized as a complication of chemotherapy when it is myelosuppressive (suppresses the bone marrow from producing blood cells). (wikipedia.org)
  • therapies
  • 3. The lab uses the genomic and metabolic information to build better representative brain tumor pre-clinical models for testing of novel therapies. (pitt.edu)
  • Once stratified, appropriate therapies can be applied allowing for personalized brain tumor therapy. (pitt.edu)
  • therapeutic
  • The Agnihotri Laboratory investigates the metabolic dependencies of brain tumors and if they can provide therapeutic vulnerabilities. (pitt.edu)
  • pancreas
  • Primary SRCC tumors are most often found in the glandular cells of the stomach (SRCC originates in the stomach in 90 percent of patients), and less frequently in the breast, gallbladder, urinary bladder, and pancreas. (wikipedia.org)
  • mammalian
  • May play also an essential role in telomere length maintenance and telomere capping in mammalian cells. (abcam.cn)
  • diagnosis
  • SRCC tumors grow in characteristic sheets, which makes diagnosis using standard imaging techniques, like CT and PET scans, less effective. (wikipedia.org)
  • encodes
  • Some cases are inherited, and these cases are often caused by mutations in the CDH1 gene, which encodes the important cell-cell adhesion glycoprotein E-cadherin. (wikipedia.org)
  • vertebrate
  • Most nonproliferating vertebrate cells will enter the G0 phase. (wikipedia.org)
  • After a vertebrate cell has been in the G1 phase for about three hours, the cell enters a restriction point in which it is decided whether the cell will move forward with the G1 phase or move into the dormant G0 phase. (wikipedia.org)
  • growth
  • G1 phase together with the S phase and G2 phase comprise the long growth period of the cell cycle called interphase that takes place before cell division in mitosis (M phase). (wikipedia.org)
  • G1 phase and the other subphases of the cell cycle may be affected by limiting growth factors such as nutrient supply, temperature, and room for growth. (wikipedia.org)
  • Physiological temperatures are optimal for cell growth. (wikipedia.org)
  • In order for the cell to continue through the G1-pm, there must be a high amount of growth factors and a steady rate of protein synthesis, otherwise the cell will move into G0 phase. (wikipedia.org)
  • The first restriction point is growth-factor dependent and determines whether the cell moves into the G0 phase, while the second checkpoint is nutritionally-dependent and determines whether the cell moves into the S phase. (wikipedia.org)
  • Reasons the cell would not move into the S phase include insufficient cell growth, damaged DNA, or other preparations have not been completed. (wikipedia.org)
  • This proto-oncogene may play a role in the regulation of embryonic development and cell growth. (wikipedia.org)
  • Polyamines are ubiquitous small molecules involved in many normal cellular functions, including transcribing and translating genes, regulating ion channels and cell-to-cell interactions, and powering cell growth and replication. (wikipedia.org)
  • Constitutive action of the ErbB2/ErbB3 complex also enhances cell growth. (wikipedia.org)
  • These complexes, which help regulate cell growth in addition to creating and maintaining epithelial layers, are known as adherens junctions and they typically include at least cadherin, β-catenin, and α-catenin. (wikipedia.org)
  • While less attention is directed at α-catenin in studies involving cell adhesion, it is nonetheless an important player in cellular organization, function and growth. (wikipedia.org)
  • lung
  • Dr. Chao will highlight previously announced laboratory and animal data that demonstrates the potential for L-DOS47 to bind to and debilitate and destroy human lung adenocarcinoma cells. (drugs.com)
  • mice
  • Using skin-targeted transgenic mice, she demonstrated that elevated levels of ODC play a causal role in the development of tumors. (wikipedia.org)
  • In the study, reporter mice were used to track stem cells. (wikipedia.org)
  • Mice lacking plakoglobin have cell adhesion defects in many tissues, although β-catenin substitutes for plakoglobin at many cellular junctions. (wikipedia.org)
  • mutations
  • In a tumor, there is a collection of mutations that are typos in the genetic material, which disrupts the function of the normal cell. (wikipedia.org)
  • receptor
  • c-Src is a widely studied member of non-receptor tyrosine kinases which are not associated with a cell-surface receptor. (wikipedia.org)
  • First of all, by binding to cadherin receptor intracellular cytoplasmic tail domains, it can act as an integral component of a protein complex in adherens junctions that helps cells maintain epithelial layers. (wikipedia.org)
  • stem cell
  • The augnting outes of CR on intestinal stem cell self renewal can be mimicked by rapamycin. (xobor.com)
  • brain
  • Brain tumors occur in different regions of the brain and have distinct genomics. (pitt.edu)
  • The causes of brain ischemia vary from sickle cell anemia to congenital heart defects. (wikipedia.org)
  • Focal brain ischemia reduces blood flow to a specific brain region, increasing the risk of cell death to that particular area. (wikipedia.org)
  • Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison their healthy counterparts. (wikipedia.org)
  • Sickle cell anemia may cause brain ischemia associated with the irregularly shaped blood cells. (wikipedia.org)
  • Sickle shaped blood cells clot more easily than normal blood cells, impeding blood flow to the brain. (wikipedia.org)
  • Papillary Tumors of the Pineal Region are located on the pineal gland which is located in the center of the brain. (wikipedia.org)
  • The ependymal cells line the inside of the ventricles of the brain. (wikipedia.org)
  • This is why brain tumors are so dangerous. (wikipedia.org)
  • cellular
  • Scientific discoveries: Gilmour's study of polyamines has broadened the scope of medical knowledge about tumor function at the cellular and molecular levels. (wikipedia.org)
  • adhesion
  • Cell-cell adhesion complexes are required for simple epithelia in higher organisms to maintain structure, function and polarity. (wikipedia.org)
  • Keratinocytes engineered to not express alpha-catenin have disrupted cell adhesion and activated NF-κB. (wikipedia.org)
  • indicate
  • For instance, when an epithelial layer is complete and the adherens junctions indicate that the cell is surrounded, β-catenin may play a role in telling the cell to stop proliferating, as there is no room for more cells in the area. (wikipedia.org)
  • known
  • The phage gene and insert DNA hybrid is then inserted (a process known as "transduction") into Escherichia coli (E. coli) bacterial cells such as TG1, SS320, ER2738, or XL1-Blue E. coli. (wikipedia.org)
  • Within the cell cycle, there is a stringent set of regulations known as the cell cycle control system that controls the timing and coordination of the phases to ensure a correct order of events. (wikipedia.org)
  • Biochemical triggers known as cyclin-dependent kinases (Cdks) switch on cell cycles events at the corrected time and in the correct order to prevent any mistakes. (wikipedia.org)
  • Between the beginning of the G1 phase (which is also after mitosis has occurred) and R, the cell is known as being in the G1-pm subphase, or the post-mitotic phase. (wikipedia.org)
  • After R and before S, the cell is known as being in G1-ps, or the pre S phase interval of the G1 phase. (wikipedia.org)
  • Per usual in non-apoptotic growing cells caspase activated dnase is held in check inactivated in the cytoplasm thanks to the association with its inhibitor, inhibitor of caspase-activated DNase (ICAD) also known as DNA fragmentation factor 45 kDa (DFF45). (wikipedia.org)
  • These tumors, papillary tumors in this case, have no known predisposing genetic characteristics, as stated by Dr. Janss when I interviewed her. (wikipedia.org)
  • The SRCC tumor is often seen in the peritoneum and has also been known to spread to lymphatic permeation of the lungs and to the ovaries, creating Krukenberg tumors. (wikipedia.org)
  • type
  • She said that there is nothing that links the likelihood of getting this tumor type to genetics, meaning nothing is inherited. (wikipedia.org)
  • Febrile neutropenia is the development of fever, often with other signs of infection, in a patient with neutropenia, an abnormally low number of neutrophil granulocytes (a type of white blood cell) in the blood. (wikipedia.org)
  • normal
  • In humans, the normal physiological temperature is around 37 °C (98.6 °F). G1 phase is particularly important in the cell cycle because it determines whether a cell commits to division or to leaving the cell cycle. (wikipedia.org)
  • Polyamine levels are dramatically elevated in tumor cells compared to normal cells. (wikipedia.org)
  • The tumor cells may differ in their structure and function, but they all have normal function, which is directed by the deoxyribonucleic acid, or DNA. (wikipedia.org)
  • however
  • However, all cicatricial alopecias involve inflammation directed at the upper part of the hair follicle where the stem cells and sebaceous gland (oil gland) are located. (wikipedia.org)
  • region
  • Cystic tumour of atrioventricular nodal region (CTAVN) CTAVN is of endodermal origin and occurs exclusively in the area of the AV node, tricuspid valve, and interatrial septum. (wikipedia.org)
  • Papillary tumors of the pineal region (PTPR) were first described by A. Jouvet et al. (wikipedia.org)
  • Papillary tumors of the central nervous system and particularly of the pineal region are very rare and so diagnosing them is extremely difficult. (wikipedia.org)
  • There are meant to be certain cells in a specific area, for the pineal region these are ependymal cells, and the cells divide into millions. (wikipedia.org)
  • Papillary tumor of the pineal region (PTPR) is a recently described neoplasm that has been formally recognized in the 2007 World Health Organization (WHO) "Classification of Tumors of the Nervous System. (wikipedia.org)
  • different
  • The duration of each phase, including the G1 phase, is different in many different types of cells. (wikipedia.org)
  • The restriction point (R) in the G1 phase is different from a checkpoint because it does not determine whether cell conditions are ideal to move on to the next phase, but it changes the course of the cell. (wikipedia.org)
  • inhibition
  • Over-expression of PPARδ also sensitised THP-1 cells to phorbol ester and correspondingly, inhibition of PPARδ by anti-sense RNA completely abolished this response. (biomedcentral.com)
  • β-catenin acts by anchoring the actin cytoskeleton to the junctions, and may possibly aid in contact inhibition signaling within the cell. (wikipedia.org)
  • blood
  • Tumors are one cause of blood vessel compression. (wikipedia.org)
  • Granulysin is a cytolytic and proinflammatory molecule first identified by a screen for genes expressed "late" (3-5 days) after activation of human peripheral blood mononuclear cells. (wikipedia.org)
  • enables
  • If a "phagemid" vector is used (a simplified display construct vector) phage particles will not be released from the E. coli cells until they are infected with helper phage, which enables packaging of the phage DNA and assembly of the mature virions with the relevant protein fragment as part of their outer coat on either the minor (pIII) or major (pVIII) coat protein. (wikipedia.org)
  • form
  • At the G1/S checkpoint, formation of the G1/S cyclin with Cdk to form a complex commits the cell to a new division cycle. (wikipedia.org)