Tumor carcinoma. Medical search. Frequent questions

Background There is strong evidence that portal vein tumor thrombosis (PVTT) is associated with poor survival in patients with hepatocellular carcinoma (HCC). (uni-koeln.de)
Zhang Y, Xi S, Chen J, Zhou D, Gao H, Zhou Z, Xu L, Chen M. Overexpression of LAMC1 predicts poor prognosis and enhances tumor cell invasion and migration in hepatocellular carcinoma. (jcancer.org)
Chen, M. Overexpression of LAMC1 predicts poor prognosis and enhances tumor cell invasion and migration in hepatocellular carcinoma. (jcancer.org)
Irving, TX, Jan. 15, 2015 - Caris Life Sciences® today announced the presentation of data from two studies in which Caris Molecular Intelligence™, the company's panomic, comprehensive tumor profiling service, yielded insights into the biology of hepatocellular and biliary tract carcinomas, while also identifying potential treatment options for patients living with these tumor types. (carislifesciences.com)
In a presentation at the 2015 Gastrointestinal Cancers Symposium in San Francisco, Calif., the researchers reported that Caris Molecular Intelligence revealed the molecular heterogeneity of hepatocellular carcinoma (HCC) and facilitated identification of potential therapies targeting molecular subtypes of this disease, for which treatment options have heretofore been extremely limited. (carislifesciences.com)
For patients with hepatocellular and biliary tract carcinomas, the limitations of currently available treatment options underscore a great need to identify new therapies," commented Sandeep K. Reddy, M.D., chief medical officer at Caris Life Sciences, and a co-investigator in each of the two studies. (carislifesciences.com)
This study is to explore the biogenesis mechanism of a secondary hepatocellular carcinoma (HCC) based on the function of RNA binding proteins (RBPs)-encoding genes in the physiological microenvironment (PM). (peerj.com)
However, it is still enigmatic about the exact processes in which RBPs-encoding genes and the relevant genes participate in transcriptome level during the biogenesis of secondary tumor in the activity of hepatocellular carcinoma (HCC) cells. (peerj.com)
Hepatocellular carcinoma is cancer that starts in the liver. (medlineplus.gov)
Hepatocellular carcinoma is the most common type of liver cancer. (medlineplus.gov)
Hepatocellular carcinoma is not the same as metastatic liver cancer . (medlineplus.gov)
NCCN clinical practice guidelines in oncology: hepatocellular carcinoma. (medlineplus.gov)
Alternative Biomarkers to Predict Tumor Biology in Hepatocellular Carcinoma. (bvsalud.org)
Hepatocellular carcinoma (HCC) is the most frequent primary malignant liver tumor , with more than 800,000 new cases diagnosed each year and with high mortality , ranking fourth in the world in cancer deaths. (bvsalud.org)
Our aim was to assess the role of ZIP4 in invasiveness, migration and apoptosis of hepatocellular carcinoma (HCC). (ijbs.com)
ZIP4 could promote migration, invasiveness, and suppress apoptosis in hepatocellular carcinoma, and represent a novel predictor of poor prognosis and therapeutic target for patients with HCC who undergo liver transplantation. (ijbs.com)
Hepatocellular carcinoma (HCC) is a major health problem and one of the most prevalent neoplasms worldwide, especially in China. (ijbs.com)

Some common tumors, however, may not result in metastasis in a manner that parallels their incidence in the overall population. (medscape.com)
For example, prostate cancer is very common, but cutaneous metastasis from prostate carcinoma is relatively uncommon. (medscape.com)
The term carcinoma of unknown primary site (CUPS) is used when dealing with a metastasis that occurs before primary tumor diagnosis. (medscape.com)
Adenoid cystic carcinoma (ACC) is a tumor characterized by slow growth and late distant metastasis. (hindawi.com)
Colonic metastasis of such a tumor is rare, with few case reports available. (hindawi.com)
Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)
The most important prognostic factors are tumor size, local spread and distant metastases, tumor node metastasis (TNM) staging. (diva-portal.org)
The tumor staging of the patients was performed in accordance with the American Joint Committee on Cancer tumor-node metastasis (TNM) classification ( 12 ). (spandidos-publications.com)
LAMC1 encodes an extracellular matrix protein, laminin γ1 chain, which is involved in several biological and pathological processes including tissue development, tumor cell invasion and metastasis. (jcancer.org)
Invasive micropapillary carcinoma of the breast (IMPC) is a rare subtype of breast cancer that has a high frequency of lymph node (LN) involvement and metastasis to distant organs. (jcancer.org)
In comparing the clinicopathological features of 451 IMPC patients and 282 IDC-NST patients, our results showed that tumor emboli were significantly higher in IMPC patients and were associated with a high frequency of metastasis. (jcancer.org)
Small renal cell carcinoma (RCC) tumors are believed to have a negligible risk of metastasis. (canjurol.com)
We report on a 77-year-old man presenting with extremity weakness who was found to have a 2.5 cm brain metastasis from a subsequently discovered 1.6 cm clear cell RCC primary tumor. (canjurol.com)
We review what is known about synchronous and metachronous metastasis from small renal tumors and prognostic features informing treatment for such lesions. (canjurol.com)
Targeting α5β1 integrins might not only prevent metastasis of HNSCC but also delay the development of the primary tumor by reducing tumor cell viability. (cipsm.de)
The tumor microenvironment (TM) in close contact with cancer cells is highly related to tumor growth and cancer metastasis. (peerj.com)
Surgery for bone metastasis in colorectal carcinoma is well tolerated, and can be considered for palliative care. (sciedupress.com)
provided the first demonstration that maximum primary tumor diameter (MPTD) was an important prognostic factor for 5-year overall survival (OS), failure-free survival (FFS), distant metastasis-free survival (DMFS) and local relapse-free survival (LRFS) in NPC [ 13 ]. (biomedcentral.com)
ZIP4 expression was significantly associated with tumor recurrence ( P = 0.002), tumor node metastasis stage ( P = 0.044), Child-Turcotte-Pugh score ( P = 0.042), and tumor size ( P = 0.022). (ijbs.com)
Anaplastic thyroid carcinoma (ATC) is an extremely malignant type of endocrine cancer frequently accompanied by extrathyroidal extension or metastasis through mechanisms that remain elusive. (biomedcentral.com)
Loss of CREB3L1 inhibited metastasis and tumor growth of ATC xenografts in zebrafish and nude mouse model. (biomedcentral.com)
The tumors frequently present at advanced stages, and around 70% of patients present with metastasis to the cervical lymph nodes. (wikipedia.org)
Metastasis to regional lymphnodes is common as the tonsil has a rich supply of lymphatics giving way to the tumor cells to metastasis to other lymph nodes (commonly the lymph nodes of neck) and cause lymphydenopathy. (wikipedia.org)
Metastasis is common in tonsillar carcinoma. (wikipedia.org)

Malignant tumor, as a new "system" in the body, is gestated by the organic environment which is the time and space for a tumor system to survive and to proliferate, especially the microenvironment that is in close contact with cancer cells. (peerj.com)
Because most of the findings involve tumors (benign and malignant), treatment is often surgical. (medscape.com)
Sarcomatoid renal cell carcinoma (SRCC) is currently defined in the 2004 World Health Organization (WHO) classification of renal tumors as any histologic type of renal cell carcinoma (RCC) containing foci of high-grade malignant spindle cells. (medscape.com)
RR CC was named for its morphologic resemblance to pediatric malignant rhabdoid tumor (MRT) of the kidney, which is a highly aggressive tumor characterized by cells that resemble rhabdomyoblasts and by genetic alterations involving chromosome 22, particularly the hSNF5/INI1 gene on 22q11.2. (medscape.com)
Carcinoma refers to a malignant neoplasm of epithelial origin or cancer of the internal or external lining of the body. (hospiceofqueenannes.com)
Anaplastic thyroid carcinoma (ATC) is a rare but extremely malignant thyroid - cancer subtype. (biomedcentral.com)
Transitional cell carcinoma is a malignant tumor arising from transitional epithelial cells that line the urinary bladder [1]. (fortuneonline.org)
Liposarcomas are malignant tumors of the lipocytes ( fat cells ) and are not commonly found in pet birds. (ivis.org)
The most common malignant tracheal tumors include squamous cell carcinoma, adenoid cystic carcinoma, carcinoid tumors, and mucoepidermoid carcinomas. (msdmanuals.com)

A few studies have reported tumors coexisting with SMBTs, such as endometrioid adenocarcinoma [ 4 ] and squamous cell carcinoma [ 5 ]. (hindawi.com)
Esophageal adenosquamous carcinoma (ASC) is a rare tumor with characteristics of adenocarcinoma (AC) and squamous cell carcinoma (SCC), the two most common esophageal cancers. (nih.gov)
Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. (bepress.com)
Here we describe the results from a phase Ib clinical trial (NCT02274155) in which 17 patients with locally advanced head and neck squamous cell carcinoma (HNSCC) received a murine anti-human OX40 agonist antibody (MEDI6469) prior to definitive surgical resection. (bepress.com)
Plasma tumor necrosis factor-α and C-reactive protein as biomarker for survival in head and neck squamous cell carcinoma. (diva-portal.org)
Tumor TNM staging is the main basis for prognosis and treatment decision for head and neck squamous cell carcinoma (HNSCC) despite significant heterogeneity in terms of outcome among patients with the same clinical stage. (diva-portal.org)
The present study investigated the expression of T helper (Th)17 cytokines in patients with laryngeal squamous cell carcinoma (LSCC) and their clinical significance in providing new therapeutic insights. (spandidos-publications.com)
95% of all laryngeal malignancies are squamous cell carcinomas (SCCs) ( 2 ). (spandidos-publications.com)
HPV infection has been reported to correlate with several cancer types, especially squamous cell carcinomas. (biochain.com)
Using Diacarta's QuantiVirus™ HPV E6/E7 RNA test, BioChain offers HPV-characterized H&N and cervix squamous cell carcinoma tissue sections from various donors as control. (biochain.com)
Distant metastases arise in 20-30% of patients with squamous cell carcinoma of the head and neck (HNSCC) in the 2 years following treatment. (cipsm.de)
This article refers to a review about head and neck squamous cell carcinoma (HNSCC), which involves about 90% of all head and neck cancers, originated from the squamous lining of the upper aero digestive tract, including the oral cavity, pharynx, larynx and sinonasal tract. (bvsalud.org)
In the upcoming years, understanding the immunobiology of head and neck squamous cell carcinoma will be accompanied simultaneously by important advances in the early detection of high-risk patients, based on the identification of biomarkers, on the manipulation of the immune system and on the understanding of the pharmacogenomics. (bvsalud.org)
We report a case of chronic Schistosoma haematobium infection with pseudometastatic pulmonary nodules and high-grade squamous cell carcinoma in a 30-year-old man in Mali. (cdc.gov)
Schistosomiasis-induced squamous cell carcinoma of the bladder with pseudometastatic pulmonary nodules in a 30-year-old man from Mali. (cdc.gov)
Anatomopathology revealed urinary schistosomiasis complicated by a high-grade, well-differentiated, keratinized squamous cell carcinoma (SCC) (Figure, panel B). Within the wall, ovoid structures, sometimes calcified, corresponded to bilharzia eggs. (cdc.gov)
Is squamous cell carcinoma an epithelial tumor? (hospiceofqueenannes.com)
Does squamous cell carcinoma affect epithelial tissue? (hospiceofqueenannes.com)
Is squamous cell carcinoma a Tumour? (hospiceofqueenannes.com)
About 2 out of 10 skin cancers are squamous cell carcinomas (also called squamous cell cancers). (hospiceofqueenannes.com)
Is squamous cell carcinoma simple or stratified? (hospiceofqueenannes.com)
What is Stage 2 squamous cell carcinoma? (hospiceofqueenannes.com)
Do you need chemo for squamous cell carcinoma? (hospiceofqueenannes.com)
How long can you live with squamous cell carcinoma? (hospiceofqueenannes.com)
Most (95% to 98%) of squamous cell carcinomas can be cured if they are treated early. (hospiceofqueenannes.com)
Once squamous cell carcinoma has spread beyond the skin, though, less than half of people live five years , even with aggressive treatment. (hospiceofqueenannes.com)
Ninety percent of all occurrences of bladder cancer are due to Transitional cell carcinoma (TCC), whereas only 5% are due to squamous cell carcinoma, and the remaining 5% include rare subtypes such as adenocarcinoma, sarcoma, and metastatic urothelial cancer [5]. (fortuneonline.org)
The aim of the present study was to examine KLF6 gene status and expression in head and neck squamous cell carcinomas (HNSCC). (mssm.edu)
Carcinoma of the tonsil is a type of squamous cell carcinoma. (wikipedia.org)
The tonsil is the most common site of squamous cell carcinoma in the oropharynx. (wikipedia.org)
citation needed] The fourth edition of WHO' s classification of head and neck tumors subdivides squamous cell carcinoma of the tonsil into two types: HPV positive or negative. (wikipedia.org)
BACKGROUND: Analyses of clinical outcomes following radiotherapy (RT) have advanced our understanding of fundamental radiobiological characteristics in head and neck squamous cell carcinoma (HNSCC). (lu.se)

Head and neck cancer (HNC) is a collective name for heterogeneous tumors located in the head and neck regions for which smoking, alcohol and human papillomavirus (HPV) are documented risk factors. (diva-portal.org)
Compared to other head and neck carcinomas, nasopharyngeal carcinoma (NPC) has a number of unique characteristics. (biomedcentral.com)

abstract = "The Kr{\"u}ppel-like transcription factor (KLF6) gene is a tumor suppressor gene (TSG) reported to be dysregulated and inactivated through loss of heterozygosity (LOH) and/or somatic mutation in a number of major human cancers. (mssm.edu)

Metastatic adenoid cystic carcinoma (ACC) in the colon is rare, with only a few case reports available [ 2 - 4 ]. (hindawi.com)
Adenoid cystic carcinoma (ACC) is a common malignancy of salivary glands, for which the underlying genetic mechanisms of tumorigenesis are poorly understood. (nih.gov)

Cutaneous metastases from carcinoma (see the image below) are relatively uncommon in clinical practice, but they are very important to recognize. (medscape.com)
Certain attributes distinguish metastases from primary tumors. (medscape.com)
[ 2 ] On the other hand, some metastases may be epidermotropic and simulate a primary epidermal tumor. (medscape.com)
Primary cutaneous adnexal carcinomas may be difficult to distinguish from metastases in certain situations. (medscape.com)
The tumor was considered free of node involvement and metastases. (cdc.gov)

Nuclear stratification was noted, but no invasive growth was apparent in these cystic tumors. (hindawi.com)
The tumors showed glandular proliferation or small nests with invasive growth (Figure 2(d) ). (hindawi.com)
IMPC is characterized by distinct histomorphology and unfavorable prognosis when compared with invasive ductal carcinoma no special type (IDC-NST). (jcancer.org)
Invasive micropapillary carcinoma of the breast (IMPC) accounts for 5 % of all breast cancers, and displays relatively uncommon and distinct histomorphological features [ 1 ]. (jcancer.org)
This subtype often has a poor prognosis with the 5 y disease survival rate being 40 % versus 88 % for invasive ductal carcinoma no special type (IDC-NST). (jcancer.org)
Less invasive approaches should be considered for small tumors, and these include topical therapies as well as curettage rather than excision. (medscape.com)
The tumor grows quickly and is highly invasive. (ivis.org)
Hemangiosarcomas are locally invasive and multicentric ( having two or more primary tumors ). (ivis.org)
Breast cancer can be divided into two main groups: non-invasive or carcinoma in situ, and invasive carcinoma. (who.int)
If surgery is not possible, certain less invasive procedures can be used to remove some of the tumor. (msdmanuals.com)

The worst prognosis is related to the late diagnosis , in which the tumor is at an advanced stage and curative treatments are not efficient in terms of increasing overall survival . (bvsalud.org)
Understanding the clinicopathological correlation and tumor grading in TCC is essential for effective management and prognosis. (fortuneonline.org)
Tumour development, histology and grade of breast cancers: prognosis and progression. (who.int)

In this study, a possible role of plasma interleukin-2 (IL-2), interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) as biomarkers for survival of HNSCC patients was investigated. (diva-portal.org)
Our findings indicate that CRP and TNF-α might be suitable as biomarkers in combination with tumor TNM staging for predicting survival and individualized treatment of HNSCC patients. (diva-portal.org)
In a separate presentation, use of Caris Molecular Intelligence reportedly uncovered distinct targetable biomarkers in biliary tract carcinomas such as extrahepatic cholangiocarcinoma (EHCC), intrahepatic cholangiocarcinoma (IHCC), and gallbladder carcinoma (GBCA), while also suggesting the potential sensitivity of these rare, aggressive tumor types to novel and conventional therapies. (carislifesciences.com)
The response rate to checkpoint inhibitors for women with high-grade serous carcinoma of the ovary, fallopian tube, and peritoneum (HGSC) is modest, and development of predictive biomarkers is needed. (lu.se)
Potential emerging technologies such as "Radiomics", " Proteomics " and " Metabolomics " will also be discussed, which should serve as tools for the elucidation of tumor heterogeneity, as well as provide data for future studies on HCC biomarkers . (bvsalud.org)

In a primary tumor mass, the ECM is strictly modulated in a tumor - permissive way, which in turn facilitates tumor progression and influences cancer cell invasion. (biomedcentral.com)
LOH was found in approximately 30% of cases and was strongly correlated with cancer progression, tumor recurrence and decreased patient survival. (mssm.edu)
Taken together, these findings suggest that KLF6 LOH represents a clinically-relevant biomarker predicting patient survival and tumor recurrence and that dysregulation of KLF6 function plays an important role in HNSCC progression. (mssm.edu)

This case raises our awareness of such tumors as a differential diagnosis of colorectal cancer. (hindawi.com)
Research has intensified to understand ERV protein function and their role as tumor antigens and targets for cancer (immune) therapy. (frontiersin.org)
Dr. Apolo's work has focused on the development of targeted therapies, with a focus on angiogenesis, MET inhibitors, and immunotherapies for the treatment of urothelial cancer and rare genitourinary tumors, and to further our understanding of the pathways driving these diseases. (nih.gov)
In her talk, she will discuss the clinical development of these therapies, from phase 1 studies through phase 3 clinical trials for the treatment of urothelial cancer and rare genitourinary tumors. (nih.gov)
CIT): NIH Director"s Seminar Series Dr. Apolo"s work has focused on the development of targeted therapies, with a focus on angiogenesis, MET inhibitors, and immunotherapies for the treatment of urothelial cancer and rare genitourinary tumors, and to further our understanding of the pathways driving these diseases. (nih.gov)
Laryngeal carcinoma is the 11th most common form of cancer in humans worldwide ( 1 ). (spandidos-publications.com)
Myeloid suppressor cells with high arginase activity are found in tumors and spleen of mice with colon and lung cancer. (aacrjournals.org)
Although arginase activity has been described in cancer patients, it is thought to originate from tumor cells metabolizing arginine to ornithine needed to sustain rapid cell proliferation. (aacrjournals.org)
Metastatic spread is responsible for the majority of cancer-associated deaths and is affected by a variety of factors, including the deregulation of gene expression, signal transduction, and epigenetic modification, as well as epithelial-to-mesenchymal transition (EMT) and the transformation of tumor cells into stem/progenitor cells. (jcancer.org)
Tumor suppressor microRNAs can repress the pathologically causative oncogenes of the hallmarks of Cancer. (medrxiv.org)
Some people at risk for liver cancer may get regular blood tests and ultrasounds to see if tumors are developing. (medlineplus.gov)
These data confirm the presence of tumor-specific TCR within the cancer tissue and suggest the existence of shared epitopes among different patients that might be used as targets for tumor immunotherapy. (oncotarget.com)
Renal cell carcinoma (RCC) occurs with an incidence of 2-3% and is the 10th most common cancer type [ 1 , 2 ]. (oncotarget.com)
Is carcinoma an epithelial cancer? (hospiceofqueenannes.com)
Carcinomas, malignancies of epithelial tissue, account for 80 to 90 percent of all cancer cases. (hospiceofqueenannes.com)
What is the difference between cancer and carcinoma? (hospiceofqueenannes.com)
Carcinoma is a type of cancer that starts in cells that make up the skin or the tissue lining organs, such as the liver or kidneys. (hospiceofqueenannes.com)
Like other types of cancer, carcinomas are abnormal cells that divide without control . (hospiceofqueenannes.com)
Does carcinoma mean cancer? (hospiceofqueenannes.com)
The cancer is larger than 2 centimeters across, and has not spread to nearby organs or lymph nodes , or a tumor of any size with 2 or more high risk features. (hospiceofqueenannes.com)
Transitional cell carcinoma (TCC) is a common type of bladder cancer, predominantly affecting males exposed to certain chemical products and is strongly associated with tobacco consumption. (fortuneonline.org)
The cancer cells may spread to adjacent structures, to lymphatics or to distant locations in the body producing secondary tumors. (wikipedia.org)

It was further demonstrated that Th17 cells could be induced and expanded in the tumor microenvironment through cytokines produced by the tumor cells. (spandidos-publications.com)
Previous studies have confirmed that tumor immune inflammation is important in the tumor microenvironment ( 6 ). (spandidos-publications.com)
The healthy and HCC mice were used to isolate the PM, pre-tumor microenvironment (PTM), and TM. (peerj.com)
These results demonstrate that CREB3L1 maintains the CAF - like property of ATC cells by activating the ECM signaling, which remodels the tumor stromal microenvironment and drives the malignancy of ATC. (biomedcentral.com)
The extracellular matrix (ECM) is a fundamental part of the tumor microenvironment. (biomedcentral.com)
A known characteristic of ATC is its ability to easily shape the tumor matrix microenvironment. (biomedcentral.com)

Sixteen histological tumor subtypes exist and the most common are papillary, chromophobe and clear cell renal cell carcinoma (ccRCC) representing 85% of all RCC. (frontiersin.org)
In this investigation a human RCC tissue microarray (TMA) (n=374) predominantly consisting of the most common histological tumor subtypes was hybridized with an ERV-K env antibody and correlated with patient clinical data. (frontiersin.org)
High ERV-K env total protein expression of all tumor subtypes significantly correlated with low tumor grading and a longer disease specific survival using multivariable analyses. (frontiersin.org)
The data presented at the Gastrointestinal Cancers Symposium demonstrate how multiplatform molecular profiling with Caris Molecular Intelligence can yield a better understanding of tumor subtypes and their biological makeup as a means to provide therapeutic guidance. (carislifesciences.com)

In dealing with cutaneous CUPS, the age, sex, and affected skin region of the patient, as well as the histology of the lesion, are useful in determining the location of the likely primary tumor. (medscape.com)
Primary cutaneous apocrine carcinomas can be particularly difficult to differentiate from adenocarcinomas of mammary origin because of the identical morphological and immunohistochemical features they may exhibit. (medscape.com)
Mahalingam et al have shown that positive staining with D2-40, p63, and CK15 also favors a primary adnexal carcinoma. (medscape.com)
Here, we report a case of ACC arising from minor salivary gland that metastasized to the colon 19 years after the primary tumor resection, with literature review of the clinical, histological, and molecular features of ACC. (hindawi.com)
Here, we report a case of ACC metastatic to the colon 19 years after resection of the primary tumor, to broaden the differential diagnosis of colorectal malignancies and to better understand the clinical, histological, and molecular features of ACC. (hindawi.com)
The primary tumor was 4 cm in size, with multiple positive margins and lingual nerve involvement. (hindawi.com)
The results revealed that the prevalence of Th17 cells in patients with LSCC was elevated in their primary tumors, as well as in peripheral blood, compared with that in healthy controls. (spandidos-publications.com)
The present study revealed that patients with LSCC have elevated levels of Th17 cells in their primary tumors and peripheral blood compared with those in healthy controls. (spandidos-publications.com)
Furthermore, higher CD163 expression was associated with better outcome in women with no residual tumor after primary surgery (P = 0.02). (lu.se)
Similarly, reconstruction after tumor removal should take into account the likelihood of further BCCs in the vicinity and should be kept simple whenever possible (eg, second intention healing or primary closure vs use of flaps). (medscape.com)
Is maximum primary tumor diameter still a prognostic factor in patients with nasopharyngeal carcinoma treated using intensity-modulated radiotherapy? (biomedcentral.com)
The purpose of this study was to evaluate the prognostic value of maximum primary tumor diameter (MPTD) in patients with nasopharyngeal carcinoma (NPC) treated using IMRT. (biomedcentral.com)
Carcinomas may spread to other parts of the body, or be confined to the primary location. (hospiceofqueenannes.com)
citation needed] The primary tumor does not have readily discernible signs or symptoms as they grow within the tonsillar capsule. (wikipedia.org)
Congruently, primary tumor volume has proven to be an important parameter. (lu.se)
The current study aims to investigate the role of primary tumor volume, OTT and estimate α/β-ratio for p16-positive OPSCC, and to quantify the differences in radiosensitivity depending on p16-status. (lu.se)
METHODS: A cohort of 523 patients treated with RT was studied using a tumor control probability (TCP)-model that incorporates primary tumor volume (V) raised to an exponent c, OTT and α/β-estimation. (lu.se)
CONCLUSION: Primary tumor volume plays a crucial role in predicting local tumor response, particularly in p16-positive OPSCC. (lu.se)

Seromucinous borderline tumors (SMBTs) are characterized by papillary architecture reminiscent of serous tumors but composed of mucinous epithelium similar to that of the endocervix. (hindawi.com)
Translocation-associated renal cell carcinomas (RCCs) arise from the proximal tubule epithelium, similar to conventional clear cell and papillary RCCs. (medscape.com)
Xp11.2 translocation-associated renal cell carcinomas (RCCs) may have well-developed papillae, mimicking papillary RCCs. (medscape.com)
Rhabdoid differentiation is found in 3-7.5% of RCCs, most commonly in CCRCC, although rare cases have been reported involving papillary RCC, chromophobe RCC, and collecting duct (Bellini duct) carcinoma. (medscape.com)
CREB3L1 knockdown dramatically attenuated invasion of ATC cells, whereas overexpression of CREB3L1 facilitated the invasion of papillary thyroid carcinoma (PTC) cells. (biomedcentral.com)

Viruses such as Epstein-Barr virus (EBV) (majorly involved in causing nasopharyngeal carcinoma) and human papilloma virus are included in this category. (wikipedia.org)

We mapped the presence of macrophages (CD68 and CD163) and lymphocytes (CD3) located within the tumor epithelium, the cell type-specific expression of PD-L1 and PD-1, and their impact on 5-year overall survival (OS) in a consecutive cohort of 130 women diagnosed with advanced HGSC between 2011 and 2015. (lu.se)
On the other hand HPV negative tumors develop from the tonsillar surface epithelium and hence have keratinizing dysplasia. (wikipedia.org)

Peripheral blood mononuclear cells from 123 patients with metastatic renal cell carcinoma, prior to treatment, were found to have a significantly increased arginase activity. (aacrjournals.org)

This combined genetic and genomic analysis provides several candidate genes to test for functional tumor suppressor activity in ACC. (nih.gov)
Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)
It virtually shows that microRNAs could have an ability to target both oncogenes and tumor suppressor genes that contribute to its dual activity role as a tumor suppressor and oncomirs via miRNA-lncRNA-TFs-PPI Crosstalk. (medrxiv.org)
It enhances our concluded suggestion of using combination therapy of tumor suppressor genes activators with microRNAs. (medrxiv.org)

The goal of this study was to determine whether myeloid suppressor cells producing high arginase existed in renal cell carcinoma patients. (aacrjournals.org)

In conclusion, ASC/TMS1 is a novel functional tumor suppressor in renal carcinogenesis. (oncotarget.com)

Metastatic tumors involving colon are rare, accounting for only 0.338% of all colorectal malignancies in a large multi-institutional study, when lymphoproliferative diseases, direct invasion, and mesenteric and peritoneal spreading are excluded [ 1 ]. (hindawi.com)
The main focus has been on tumor cell PD-L1 expression, but its assessment alone is insufficient for patient selection in most malignancies. (lu.se)

Sometimes adnexal carcinomas arise in the setting of a precursor benign adnexal neoplasm, making diagnosis straightforward. (medscape.com)
The most common noncancerous (benign) airway tumor is a squamous papilloma, although other benign conditions can also occur. (msdmanuals.com)

However, data regarding the clinical significance of hepatic vein tumor thrombosis (HVTT) is rare, particularly in Western patients. (uni-koeln.de)
Hepatic tumors and cysts. (medlineplus.gov)

This study supports ERV-K env as a single prognostic indicator for better survival of RCC, which we propose represents a new tumor antigen. (frontiersin.org)
Analyses of CD8+ TIL show increases in tumor-antigen reactive, proliferating CD103+ CD39+ cells in 25% of patients with evaluable tumor tissue (N = 4/16), all of whom remain disease-free. (bepress.com)

Waterfowl may develop tumors in areas that are poorly feathered, suggesting an association with exposure to sunlight. (ivis.org)
larynx) can develop tumors that either grow into the structures or press on them, blocking breathing. (msdmanuals.com)

p=0.017), implying high rates of tumor proliferation and DNA synthesis, compared to non-TP53-mutated tumors. (carislifesciences.com)

Immunohistochemically, the tumor demonstrated epithelial-myoepithelial dual lineage differentiation, which confirmed the diagnosis of metastatic ACC. (hindawi.com)

He was tumor free until 9 years ago when multiple small nodules in the right lung were identified. (hindawi.com)
Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice xenografted with Lewis lung carcinoma (LLC) cells. (frontiersin.org)

However, most findings come from an era when p16-negative HNSCC was the dominant tumor type. (lu.se)
The estimated α/β-ratio for p16-positive oropharyngeal tumors aligns with previous HNSCC studies, whereas the impact of prolonged OTT was slightly less than previously reported. (lu.se)

These data provide evidence that anti-OX40 prior to surgery is safe and can increase activation and proliferation of CD4+ and CD8+ T cells in blood and tumor. (bepress.com)

Comparison of tumor biopsies before and after treatment reveals an increase of activated, conventional CD4+ tumor-infiltrating lymphocytes (TIL) in most patients and higher clonality by TCRβ sequencing. (bepress.com)
Higher levels of C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-α) were detected in plasma of the patients compared with the levels in the controls. (diva-portal.org)
A total of 70 tumors and 70 adjacent control tissues (pathologically confirmed normal mucosa) were obtained from patients with LSCC undergoing surgery. (spandidos-publications.com)
Investigators in each study examined tumor samples for underlying molecular alterations that may yield potentially different therapeutic options for patients with these tumor types. (carislifesciences.com)
Although there is no evidence of the effectiveness of cytotoxics in patients with HCC, the investigators surmised that irinotecan, alkylating agents, fluoropyrimidines, anthracyclines, nab-paclitaxel, gemcitabine, or taxanes may be therapeutically relevant in subsets of patients expressing these tumor markers. (carislifesciences.com)
In addition, Xp11.2 translocation-associated carcinoma is now being increasingly reported in patients over age 40 years. (medscape.com)
Treatment of patients with nevoid basal cell carcinoma syndrome (NBCCS) involves surveillance for and treatment of the associated findings. (medscape.com)
[ 23 ] There is not yet a specific FDA approval for the use of either drug in NBCSS, although a randomized, placebo-controlled, phase-2 trial of 42 NBCSS patients from 2012 treated with vismodegib showed a 70% reduction in the number of new surgically eligible tumors and a decrease in size of many existing tumors, sometimes dramatically. (medscape.com)
Collision tumors are rarely reported in patients with von Hippel-Lindau (VHL) disease, even though VHL patients often present with multi-organ tumor syndromes, like hemangioblastoma and renal cell carcinoma (RCC). (figshare.com)
Based on our case report, we systematically reviewed the characteristics of collision tumor composed of hemangioblastoma and metastatic RCC in VHL patients. (figshare.com)
In an attempt to evaluate the immune response of renal cell carcinoma (RCC) patients, tumor lesions and / or blood samples from 12 RCC patients underwent deep T cell receptor (TCR) sequencing. (oncotarget.com)
Most of the RCC patients presented "patient-specific" TCR sequences, and those clonotypes were present at higher frequency in tumor lesions suggesting a specific extravasation from the blood. (oncotarget.com)
Risk of death for patients with LOH was 8 times greater independent of tumor size, nodal status, tobacco smoking or treatment modality (HR 7.89, 95% CI: 1.9-32.4). (mssm.edu)
Suggest, in patients with rapid tumor growth in whom maximal doses of radiotherapy have not been reached, combination temozolomide with radiotherapy (Stupp protocol). (medscape.com)

Ovarian seromucinous borderline tumors (SMBTs) are rare. (hindawi.com)
Here, we report an unusual combination of bilateral ovarian SMBT and clear cell carcinoma associated with polypoid endometriosis of the colon, in a 62-year-old woman. (hindawi.com)
To the best of our knowledge, this is the first case of this unusual combination of ovarian seromucinous tumor and clear cell carcinoma to be reported in the English literature. (hindawi.com)
Here, we describe the first case, to our knowledge, of an unusual combination of ovarian SMBT and clear cell carcinoma. (hindawi.com)
We suggest that these ovarian tumors and colonic lesions were also associated with separate endometriotic foci. (hindawi.com)
An abdominal computed tomography scan revealed bilateral ovarian tumors and uterine leiomyoma. (hindawi.com)
Surgery for ovarian tumors or cardiac tumors may be required for either treatment or prevention of symptoms. (medscape.com)

Anatomopathology confirmed complete resection of the tumor reaching the muscle layer and the perivesical fat. (cdc.gov)

Renal cell carcinoma (RCC) is one of the ten most common cancers for men and women with an approximate 75% overall 5-year survival. (frontiersin.org)
Thus, women with greater lymphocyte tumor infiltration had better outcome and PD-L1/PD-1 expression, regardless of PD-1/PD-L1 being markers for immune suppressive pathways, conferred a survival benefit in our cohort. (lu.se)
Univariate analysis showed that ZIP4 expression was significantly associated with overall survival ( P = 0.020) and tumor-free survival ( P = 0.049). (ijbs.com)

PD-L1 was expressed mainly by macrophages (not by tumor cells) and PD-1 by lymphocytes. (lu.se)

Our data indicate that plakoglobin promotes tumor cluster formation in IMPC and downregulates apoptosis in the cell clusters through activation of PI3K/Akt/Bcl-2 signaling. (jcancer.org)

HPV positive tumors arise from the deep lymphoid tissue of the tonsillar crypts and are non-keratinizing. (wikipedia.org)

As the tonsils consist of a rich network of lymphatics, the carcinoma may metastasize to the neck lymph nodes which many are cystic. (wikipedia.org)
The carcinoma of tonsil usually spreads through the cervical lymph node levels II, III, IV, V, and retropharyngeal lymph nodes. (wikipedia.org)

Currently, the 2004 WHO classification of renal tumors recognizes this transformation as "sarcomatoid change" or "sarcomatoid features" arising within RCC, rather than as a separate histologic entity. (medscape.com)

No apparent transitional lesions were noted between the different tumor components. (hindawi.com)
Xp11.2 translocation-associated renal cell carcinomas are generally cortical or subcapsular, well-circumscribed lesions with yellow-tan, variegated cut surfaces. (medscape.com)

Seromucinous tumor cells were positive for estrogen receptor (ER) and progesterone receptor (PgR) but negative for Napsin A, p504S, and HNF1B. (hindawi.com)
These tumor cells had clear cytoplasm and a hobnail-shaped appearance (Figure 2(c) ). (hindawi.com)
At higher magnification, the tumor cells showed minimal cytological atypia, scant cytoplasm, fine chromatin, small inconspicuous nucleoli, and rare mitotic figures (Figure 2 ). (hindawi.com)
The tumor cells were round to oval with fine chromatin, small inconspicuous nucleoli, indistinct cell borders, and light nongranular cytoplasm. (hindawi.com)
the abluminal myoepithelial cells of the tumor are positive for SMA and P63. (hindawi.com)
CD34-positive cells were counted as microvessels (tan color), moderate MVDs in hot spot area of the neoplastic cells in moderately-differentiated pancreatic carcinoma. (wjgnet.com)
In conclusion, Th17 cells have a substantial impact on the carcinogenesis of LSCCs, and could serve as a potential therapeutic target to modulate the anti‑tumor response in these carcinomas. (spandidos-publications.com)
Considering these facts, it could be concluded that pro-inflammatory Th17 cells may have extensive effects on LSCC pathogenesis and anti-tumor response. (spandidos-publications.com)
Using mouse models, we validated the metastatic potential of tumor clusters was higher than single cells in vivo . (jcancer.org)
In Xp11.2 translocation-associated renal cell carcinoma (RCC), cells typically have voluminous cytoplasm, which can range from eosinophilic and granular to clear. (medscape.com)
within a given tumor, cells may be variably arranged in broad sheets, nests, trabeculae, true papillae, or pseudopapillae (see the first 3 images below). (medscape.com)
Another characteristic architectural feature found in many of these tumors is a pseudoalveolar pattern in which cells are arranged in alveolae with central cellular discohesion (see the fourth image below). (medscape.com)
Psammoma bodies and scattered xanthoma cells have been described in some tumors. (medscape.com)
at least focally, tumor cells often have abundant clear cytoplasm, mimicking clear cell RCC. (medscape.com)
In Xp11.2 translocation-associated renal cell carcinoma, tumor cells with abundant eosinophilic cytoplasm and high nuclear grade are often arranged in large nests with a delicate, intervening vascular stroma. (medscape.com)
The nests of tumor cells in Xp11.2 translocation-associated renal cell carcinomas may become centrally discohesive, giving rise to a pseudoalveolar growth pattern. (medscape.com)
Focal spindling due to noncohesion of tumor cells is not considered to represent sarcomatoid differentiation. (medscape.com)
however, occasional tumors composed entirely of rhabdoid cells have been described in which no RCC component is detected despite extensive sampling. (medscape.com)
Large tumors should be harder to cure if a successful RT requires the sterilization of all clonogenic cells. (lu.se)

[ 13 , 14 ] MRT usually arises in children younger than 3 years, and the occasional cases previously reported as adult MRT are now considered more likely to be RRCC in which rhabdoid components have overgrown the original histologic tumor type. (medscape.com)

WHO classifies urothelial carcinoma as low-grade urothelial carcinoma (LGUC) and high-grade urothelial carcinoma (HGUC) based on its cell morphology and histological structure [3, 11]. (fortuneonline.org)

The T classifications of both systems are based on tumor invasion of anatomical structures and cranial nerve paralysis, and do not include tumor size. (biomedcentral.com)

Immunohistochemistry showed different staining patterns in tumor components. (hindawi.com)

ASC/TMS1 methylation was significantly correlated with higher tumor nuclear grade. (oncotarget.com)

ASC is a rare tumor among esophageal carcinomas with a greater burden of metastatic disease than AC or SCC and worse OS than AC. (nih.gov)

A significant downregulation was also detected in sixty-seven paired renal tumors compared with adjacent non-cancerous tissues. (oncotarget.com)
Moreover, ASC/TMS1 hypermethylation was further detected in 41.1% (83/202) of RCC tumors, but only 12% in adjacent non-cancerous tissues. (oncotarget.com)

Anatomy12

Organisms6

Diseases119

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes37

Disciplines and Occupations1

Information Science4

Health Care13

Hepatocellular17

Metastasis24

Malignant9

Squamous Cell32

Head and neck2

Abstract1

Adenoid cystic ca2

Metastases5

Invasive10

Prognosis3

Biomarkers5

Progression3

Cancer22

Microenvironment6

Subtypes4

Primary18

Papillary5

Nasopharyngeal carcinoma1

Epithelium2

Metastatic renal cell carc1

Genes4

Renal cell carcinoma pat1

Functional tumor suppressor1

Malignancies2

Benign2

Hepatic2

Antigen2

Develop tumors2

High rates of tumor1

Diagnosis1

Lung2

HNSCC2

Proliferation1

Patients14

Ovarian7

Resection1

Survival3

Lymphocytes1

Promotes tumor1

Tissue1

Lymph2

Classification1

Lesions2

Cells19

Rhabdoid1

Histological1

Invasion1

Immunohistochemistry1

Significantly correlated1

Esophageal1

Tissues2