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  • Conclusions
  • Conclusions: SN tumor burden categories according to Rotterdam criteria and the positive result of LY MM-RT-PCR assay demonstrated additional, independent prognostic value in SN-positive melanoma patients, showing significant correlation with shorter DFS and OS. (eur.nl)
  • anti-tumor immune response
  • The overall aim of this thesis is to investigate the mechanisms of antibody-based immunotherapies and the role of the tumor microenvironment in mediating the anti-tumor immune response, in order to aid the development of improved immunotherapies for cancer patients. (diva-portal.org)
  • In addition, therapeutic vaccination and induction of tertiary lymphoid structures by agonistic CD40 antibodies are novel approaches to employ antibodies to modulate the anti-tumor immune response. (diva-portal.org)
  • Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice. (healthsciencessc.org)
  • human tumor
  • A marked, transient spike in circulating human tumor DNA occurred immediately after cytotoxic therapy or surgery. (aacrjournals.org)
  • Indeed, the concentration of human DNA sequences can be quantitatively assessed by real-time PCR and this principle has been applied to measure human tumor cells in the solid organs of mice, rats, and chickens ( 12 - 15 ). (aacrjournals.org)
  • quantitative
  • Quantitative imaging methods promise to improve the ability of cancer researchers to evaluate tumor burden and treatment response, but progress is thwarted by the lack of software infrastructure to record quantitative imaging information efficiently and reproducibly in the routine clinical workflow, and by the inability to store and share image metadata in standard formats. (grantome.com)
  • Many different quantitative imaging features that could more completely describe tumor burden are not being captured because collecting this information is laborious without tool support. (grantome.com)
  • Our objective is to develop software infrastructure that meets these needs of cancer researchers through three aims: (1) creating tools leveraging caBIG technologies to standardize quantitative imaging assessment of tumor burden. (grantome.com)
  • These tools will enable comprehensive and reproducible assessment of the quantitative imaging features of tumor burden as part of the routine clinical workflow and will improve the coordination of radiologists and oncologists in collecting quantitative image data. (grantome.com)
  • The methods and tools we develop will improve the ability of cancer researchers to collect and use quantitative imaging data to accurately assess tumor burden and to develop improved methods for evaluating whether treatment is effective. (grantome.com)
  • Immunotherapy
  • No significant spontaneous CTL activation against GP was observed.The data show that the tumor did not spontaneously induce or maintain an activated CTL response, revealing a profound lack of immunogenicity in vivo.Therefore, repetitive immunizations are necessary for prolonged antitumor immunotherapy. (nih.gov)
  • In addition, the data suggest that the risk for induction of chronic autoimmune diseases is limited, which may encourage immunotherapy against antigens selectively but not exclusively expressed by the tumor. (nih.gov)
  • Blood glucose levels reflect the tumor burden and the effectiveness of tumor immunotherapy in vivo. (nih.gov)
  • Tumors that have higher levels of TMB are believed to express more neoantigens - a type of cancer-specific antigen - that may allow for a more robust immune response and therefore a more durable response to immunotherapy. (genengnews.com)
  • higher tumor
  • Multivariate ordinal logistic regression revealed no significant differences in odds of higher tumor risk (odds ratio (OR) 1.22, 95% confidence interval (CI) 0.98-1.53, P=0.08), Gleason score (OR 0.90, 95% CI 0.7-1.16, P=0.4) or clinical stage (OR 1.04, 95% CI 0.79-1.38, P=0.8) for African Americans compared with Caucasians. (urotoday.com)
  • vivo
  • Interestingly, we observed striking differences in the in vivo mechanism of action of CD20 antibodies dependent on tumor load. (haematologica.org)
  • Our data suggest that complement-enhanced ADCC may critically impact tumor killing by CD20 antibodies in vivo. (haematologica.org)
  • Because both chemo- and anoikis-resistance are critical steps in the progression of ovarian cancer, we sought to determine how restoration of miR-200c affects tumor burden and chemosensitivity in an in vivo preclinical model of ovarian cancer. (aacrjournals.org)
  • In light of these problems, several studies have evaluated biochemical measurements ex vivo for internal tumor assessment. (aacrjournals.org)
  • He S, Cen B, Liao L, Wang Z, Qin Y, Wu Z, Liao W, Zhang Z, Ji A. A tumor-targeting cRGD-EGFR siRNA conjugate and its anti-tumor effect on glioblastoma in vitro and in vivo. (healthsciencessc.org)
  • mice
  • The aim of the present study was to determine the effect of blocking Fe 3+ ion binding to Ggly, using Bi 3+ , In 3+ or Ru 3+ ions, on the development of intestinal tumors in APC Δ14/+ mice. (rsc.org)
  • APC Δ14/+ mice were treated orally with Bi 3+ , In 3+ or Ru 3+ ions for up to 60 days, serum trace metals were analyzed by inductively coupled plasma mass spectrometry, and the incidence and size of intestinal tumors were assessed. (rsc.org)
  • Bi 3+ treatment significantly decreased the number of tumors larger than 3 mm in male mice. (rsc.org)
  • In 3+ or Ru 3+ treatment significantly increased the tumor burden in all animals and In 3+ increased the number of tumors larger than 3 mm or 5 mm in male mice alone. (rsc.org)
  • Increasingly strong signals were detected in lung sections in mice with larger tumor loads. (aacrjournals.org)
  • Subcutaneous tumors in mice are most often used to evaluate issues relating to tumorigenicity and therapy, as tumor growth can be easily measured in such systems by visual inspection. (aacrjournals.org)
  • Accordingly, many sophisticated methods have been devised to follow such tumors in mice. (aacrjournals.org)
  • In this study, we show that coinoculation of BJ human skin fibroblast cells with DU145 human prostate carcinoma cells subcutaneously into nude mice dramatically decreased tumor latency as well as increased tumor burden. (aacrjournals.org)
  • 5 mM (at an age of 70-85 d) and age-matched control mice were infected with LCMV to induce tumor-specific CTLs. (nih.gov)
  • To generate double transgenic RIP(GP × Tag2) mice, tumor-susceptible RIP-Tag2 mice were crossed with transgenic RIP-GP mice expressing the LCMV-GP on pancreatic β cells. (nih.gov)
  • This occurred in tumor-bearing RIP-Tag2 and RIP(GP × Tag2) mice, which both developed hypoglycemia at the age of 70-85 d (Fig. 1 A). As expected, control C57BL/6 and RIP-GP mice showed normal blood glucose levels. (nih.gov)
  • Differences in the number of tumors were strongly associated with the baseline microbiome structure in mice, but not with the cancer status of the human donors. (biomedcentral.com)
  • Multiple Myeloma
  • Notably, SRF231 administration led to profound tumor growth inhibition in models of multiple myeloma, diffuse large B cell lymphoma and Burkitt's lymphoma as a single agent and in combination with opsonizing antibodies. (bloodjournal.org)
  • antigen
  • High expression of CD47 on tumors blocks phagocytic uptake, subsequent antigen cross-presentation and T cell activation, which collectively contribute to tumor immune evasion. (bloodjournal.org)
  • The simian virus 40 T antigen (Tag) expressed under the control of the rat insulin promoter (RIP) induced pancreatic beta-cell tumors producing insulin, causing progressive hypoglycemia. (nih.gov)
  • characteristics
  • We compared African Americans and Caucasians with respect to tumor characteristics using ordinal logistic regression, treatment choice across substrata of tumor risk using logistic regression, and cancer-specific and other-cause mortality using competing risks regression analysis. (urotoday.com)
  • Metastases
  • The risk of non-SLN metastases was higher in case of SLN macrometastases (compared with micrometastases), a high positive/total SLN ratio and Elston grade 3 tumours, and increased with increasing tumour size. (diva-portal.org)
  • disease burden
  • By focused profiling of a mechanistically relevant circulating T-cell subpopulation calibrated to pretreatment disease burden, we identify a clinically accessible potential on-treatment predictor of response to PD-1 blockade. (nature.com)
  • Traditional magnetic resonance imaging (MRI) has limited ability to assess disease burden accurately. (harvard.edu)
  • negatively
  • CTLA-4 and PD-1 negatively regulate the anti-tumor T-cell response and blocking these immune checkpoints with antibodies enhances anti-tumor immunity. (diva-portal.org)
  • Members of the Gram-positive Clostridiales, including multiple members of Clostridium Group XIVa, were strongly negatively correlated with tumors. (biomedcentral.com)
  • induces
  • In summary, the CD47 mAb SRF231 induces robust tumor cell phagocytosis and tumor clearance both alone and in combination with opsonizing antibodies in pre-clinical models of myeloma and lymphoma. (bloodjournal.org)
  • transgenic
  • In conclusion, application of the Mutector kit to detect mutant K-ras message provided a sensitive, accurate, and quantifiable method for evaluating tumor loads in mouse K-ras lung cancer model and could be applied to other transgenic models. (aacrjournals.org)
  • correlation
  • SN tumor burden showed linear correlation with increasing Breslow thickness (P = .01). (eur.nl)
  • Analysis of the inferred metagenome of each community revealed a negative correlation between tumor count and the potential for butyrate production, and a positive correlation between tumor count and the capacity for host glycan degradation. (biomedcentral.com)
  • cancer
  • Although these models have many advantages over injection of lung cancer cell lines, it has been difficult to quantify the amount of tumor within the lungs by using histologic examination. (aacrjournals.org)
  • Cancer researchers are therefore gradually turning to human xenograft models in which tumors are formed internally, either through metastasis or implantation, to more accurately mimic human disease ( 6 , 7 ). (aacrjournals.org)
  • nodal
  • There was a significantly greater axillary burden in the ultrasound positive versus negative groups (OR 5.95, 95% CI 5.80-6.11) with mean nodal retrieval values of 2.9 [standard error (SE) 0.and 1.6 (SE 0.2) nodes, respectively. (springermedizin.de)
  • Treatment
  • However, further testing of higher doses of Bi 3+ ions for longer periods as an oral treatment for intestinal tumors is warranted. (rsc.org)
  • Tumor-associated macrophage (TAM) numbers and polarization status are also modulated by SRF231 treatment. (bloodjournal.org)
  • 2017
  • OncologyPRO has evolved in July 2017 to offer you direct access to our rich content either by tumour site or according to the objectives of your visit. (esmo.org)