Solid tumorsMicroenvironmentMolecularMalignantLymphocytesVivoProgressionMetastasisAnti-tumorStructural characterizationInduceProteinsCeramideMonoclonal antibodyMalignancyGlycosphingolipidsExtracellularVitroAngiogenesisSialicOften correlatedMelanomaTILsInvasivenessImmunosuppressiveTissueAntigensLymphaticMechanismsAggressiveMarkersDifferentiationCellsClinicalPromotesAdditionallyTransportersHumanRadiationCompositionDominantCellFrequentPlasmaTissuesPrimaryBrainContent
Solid tumors4
- Immune-checkpoint proteins that are highly expressed in cancer cells play a crucial role in the inhibition of immune cells Dr. Battula is interested in identification and targeting of immune checkpoint proteins in solid tumors and hematologic malignancies. (mdanderson.org)
- The data indicate that scFv78, the first fully human anti-TEM1 recombinant antibody, recognizes both human and mouse TEM1 and has unique and favorable features that are advantageous for the development of imaging probes or antibody-toxin conjugates for a large spectrum of human TEM1-positive solid tumors. (atsbio.com)
- It is widely accepted that hypoxic stresses occur in most solid tumors. (nutriforce.cn)
- Thus, solid tumors seem to build up a hostile hypoxic microenvironment that hampers cell-mediated immunity and dampen the efficacy of the immune response. (nutriforce.cn)
Microenvironment7
- While GB tumors are frequently infiltrated by natural killer (NK) cells, these are actively suppressed by the GB cells and the GB tumor microenvironment. (frontiersin.org)
- Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
- Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)
- However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
- The microenvironment of a developing tumor is composed of proliferating cancer cells, blood vessels, stromal cells, infiltrating inflammatory cells, and a variety of associated tissue cells. (nutriforce.cn)
- Accumulating data also suggest that hypoxic stress in the tumor microenvironment promotes tumor escape mechanisms through the emergence of immune-resistant tumor variants and immune suppression. (nutriforce.cn)
- The RAS plays a crucial role in cancer biology and affects tumor growth and dissemination directly and indirectly by remodeling the tumor microenvironment. (nutriforce.cn)
Molecular3
- His research program spans a range from basic studies in molecular cancer genetics and tumor immunology to translational clinical cancer research testing novel immunotherapeutic strategies and targeted compounds in vivo for the treatment of gynecologic malignancies. (yale.edu)
- Molecular characterisation in tongue squamous cell carcinoma reveals key variants potentially linked to clinical outcomes. (cdc.gov)
- Glioma grading, molecular feature classification, and microstructural characterization using MR diffusional variance decomposition (DIVIDE) imaging. (lu.se)
Malignant5
- Anaplastic ganglioglioma is a rare, poorly characterized, malignant neuronal-glial tumor type. (bvsalud.org)
- Glioblastoma (GB) is the most frequent malignant primary brain tumor in adults, without any curative treatment options available at present. (frontiersin.org)
- Colorectal cancer (CRC) is one of the most common human malignant tumors worldwide. (afpm.org.my)
- Arising from the transformation of epithelial cells in the colon and/or rectum into malignant cells, the foundation of CRC pathogenesis lies in the progressive accumulation of mutations in oncogenes and tumor-suppressor genes, such as APC and KRAS. (afpm.org.my)
- The crosstalk between stromal cells and malignant cells within this environment crucially determines the fate of tumor progression, its hostility, and heterogeneity. (nutriforce.cn)
Lymphocytes2
- In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
- In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
Vivo4
- In PNS axons, axotomy activates Neu3 sialidase, increasing the ratio of GM1/GD1a and GM1/GT1b gangliosides immediately after injury in vitro and in vivo . (jneurosci.org)
- Binding assays and PK studies were compared with one-way analysis of variance (ANOVA), ADCC and ADCP assays and in vivo tumor outgrowth with two-way ANOVA followed by Tukey's post-hoc test. (bmj.com)
- Furthermore, IgA3.0 ch14.18 penetrates neuroblastoma tumors in vivo and halts tumor outgrowth in both 9464D-GD2 and IMR32 long-term tumor models. (bmj.com)
- In Vivo tagging and characterization of s-glutathionylated proteins by a chemoenzymatic method. (sinica.edu.tw)
Progression2
- Upregulation of acid ceramidase contributes to tumor progression in Tuberous Sclerosis Complex. (ailam.it)
- Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis. (frontiersin.org)
Metastasis1
- Overall, Dr. Battula's lab is interested in understanding the mechanisms contributing chemo-resistance, tumor initiation and metastasis of cancer stem cells. (mdanderson.org)
Anti-tumor1
- This antigen sequence represents the complete Bevacizumab binding site and using RFASE as adjuvant, the vaccine (hVEGF 26-104 /RFASE) induces an immune response with VEGF neutralizing activity and anti-tumor effect [15]. (researchsquare.com)
Structural characterization1
- EndoBI-1-released N-glycans were quantified by a phenol-sulphuric total carbohydrate assay and the resultant N-glycan structures monitored by nano-LC-Chip-Q-TOF MS. The kinetic parameters and structural characterization of glycans released suggest EndoBI-1 can facilitate large-scale release of complex, bioactive glycans from a variety of glycoprotein substrates. (omicsdi.org)
Induce1
- In most tumor types, MSCs support tumor growth and induce chemo-resistance in cancer cells. (mdanderson.org)
Proteins1
- For this purpose, glioneuronal tumors in mice were induced by intraventricular in utero electroporation (IUE) of piggyBac-based plasmids for BRAFV600E and activated Akt (AktT308D/S473D, further referred to as AktDD) and analyzed neurochemically by immunocytochemistry against specific marker proteins. (bvsalud.org)
Ceramide3
- Ten out of twelve MS-identified ganglioside classes, defined by unique glycan residues, were represented by a large number and considerable abundance of individual species with different fatty acid residues (C16-C24) in ceramide portions. (bvsalud.org)
- Specific ganglioside composition and large variability of ganglioside ceramide structures determined in anaplastic ganglioglioma demonstrate realistic ganglioside expression patterns and correspond to the profile of high-grade malignancy brain tumors. (bvsalud.org)
- It is phosphorylated by ceramide kinase (CK) to form ceramide-1-phosphate or it can be glycosylated by glucosylceramide synthase to form glycosphingolipids (cerebrosides, globosides, gangliosides). (frontiersin.org)
Monoclonal antibody2
- These elicited antibodies impaired the high affinity interaction between VEGF and monoclonal antibody Bevacizumab, an antiangiogenic drug approved in combination with chemotherapy for the treatment of different tumors. (researchsquare.com)
- So far, the most successful passive immunotherapy directed to VEGF is Bevacizumab, a monoclonal antibody that neutralizes the binding of VEGF to its receptors [5], which has been approved, in combination with chemotherapy, for the treatment of different tumors [6-12]. (researchsquare.com)
Malignancy1
- It has become clear that hypoxia shapes and induces specific macrophage phenotypes that serve tumor malignancy, as hypoxia promotes immune evasion, angiogenesis, tumor cell survival, and metastatic dissemination. (nutriforce.cn)
Glycosphingolipids1
- Gangliosides, complex glycosphingolipids on the plasma membrane containing one or more sialic acid residues, are key components of microdomains. (jneurosci.org)
Extracellular3
- Ultracentrifugation of the tumor ascites fluid has now revealed a pellet that contains small extracellular vesicles (EV) with an average diameter of 80 nm. (aacrjournals.org)
- Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
- Characterization of surface markers on extracellular vesicles isolated from lymphatic exudate from patients with breast cancer. (gu.se)
Vitro2
- We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)
- Conclusions IgA3.0 ch14.18 is a promising new therapy for neuroblastoma, showing (1) increased half-life compared to natural IgA antibodies, (2) increased protein stability enabling effortless production and purification, (3) potent CD89-mediated tumor killing in vitro by healthy subjects and patients with neuroblastoma and (4) antitumor efficacy in long-term mouse neuroblastoma models. (bmj.com)
Angiogenesis2
- Angiogenesis is the formation of new blood vessels from the existing vasculature, and it is significantly increased during tumor development with the aim to supply nutrients and oxygen that support the high rate proliferation of tumor cells. (researchsquare.com)
- VEGF biological activity is mediated by its binding to VEGFR receptor 2 (VEGFR2) or VEGF receptor 1 (VEGFR1) [2], and both interactions have been implicated in tumor-induced angiogenesis and immunosuppression [3, 4]. (researchsquare.com)
Sialic1
- Based on the ganglio GSL series, gangliosides are synthesized, where sialic acids are linked to the glycan structure to produce negatively charged GSLs. (springer.com)
Often correlated1
- The role of tumor-associated macrophages (TAMs) in cancer is often correlated with poor prognosis, even though this statement should be interpreted with care, as the effects of macrophages primarily depend on their localization within the tumor. (nutriforce.cn)
Melanoma5
- The establishment and characterisation of paired autologous tumour cell line (MST-1) and tumour-infiltrating lymphocyte (TIL) culture from a tumour mass of a 14-year-old Taiwanese girl with soft tissue melanoma are described. (tmu.edu.tw)
- Immunostaining revealed that major melanoma-associated antigens, such as S100 protein, HMB-45, melanotransferrin, chondroitin sulphate proteoglycan, and the gangliosides GD2 and GD3, were consistently expressed by the tumour tissue, severe combined immunodeficiency (SCID) mouse xenograft and derived cell lines. (tmu.edu.tw)
- This observation and the expression of the major melanoma-associated antigens were all indicative of the melanocytic origin of MST-1 tumour. (tmu.edu.tw)
- The availability of the soft tissue melanoma cell line, the SCID mouse xenograft tumour system as well as autologous TILs described herein would provide useful materials for identifying T-cell-defined antigens as well as a model system for devising individualised cancer biotherapeutic strategies. (tmu.edu.tw)
- 1989) Characterization of IgG and IgM antibodies induced in melanoma patients by immunization with purified GM2 gangliosideM2 (harekrishnaforex.com)
TILs1
- Interleukin-2 (IL-2) expanded TILs had the predominant CD8 + phenotype and the capacity to lyse cells of the cultured autologous tumour. (tmu.edu.tw)
Invasiveness1
- Gangliosides serve as antitumor therapy targets and aberrations in their composition strongly correlate with tumor growth and invasiveness. (bvsalud.org)
Immunosuppressive2
- The identification of immunosuppressive factors within human tumor microenvironments, and the ability to block these factors, would be expected to enhance patients' antitumor immune responses. (aacrjournals.org)
- iii) The hypoxic tumor environment is immunosuppressive and prevents an antitumor response. (nutriforce.cn)
Tissue3
- Anaplastic ganglioglioma ganglioside composition was highly distinguishable from both peritumoral and healthy tissue despite having five to six times lower total content. (bvsalud.org)
- The peritumoral tissue ganglioside composition was estimated as normal. (bvsalud.org)
- Multidimensional diffusion magnetic resonance imaging for characterization of tissue microstructure in breast cancer patients: A prospective pilot study. (lu.se)
Antigens1
- NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
Lymphatic1
- Isolation and characterisation of lymphatic endothelial cells from lung tissues affected by lymphangioleiomyomatosis. (ailam.it)
Mechanisms1
- In this paper, we examine Neu3 sialidase action on axonal gangliosides and resultant axon regeneration, and we assess whether these mechanisms help to explain the different regeneration capacities of CNS and PNS axons. (jneurosci.org)
Aggressive3
- Glioblastoma Multiforme (GBM) is the most aggressive form and most common primary brain tumour in adults. (patentpc.com)
- Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and currently incurable. (frontiersin.org)
- Moreover, cancer cells found within hypoxic regions are presumed to represent the most aggressive and therapy-resistant fractions of the tumor. (nutriforce.cn)
Markers1
- He discovered unique markers including ganglioside GD2 and GD3 synthase to identify/isolate CSCs from primary breast tumors (Battula et al. (mdanderson.org)
Differentiation1
- Thus, a careful characterization and understanding of this macrophage differentiation state is needed in order to efficiently tailor cancer therapy. (nutriforce.cn)
Cells5
- Interestingly, tumor cells maintained the potential to express both receptors. (bvsalud.org)
- His current research is focused on understanding the role of tumor-stroma interactions in chemo-resistance of acute myeloid leukemia (AML) cells. (mdanderson.org)
- Dr. Battula's research is also focused on targeting cancer stem cells (CSCs), a rare population of cells present in the primary tumor that are drug resistant and primary cause of disease relapse. (mdanderson.org)
- We previously established that an unidentified factor, or factors, present in ovarian tumor ascites fluids reversibly inhibited the activation of T cells by arresting the T-cell signaling cascade. (aacrjournals.org)
- Results ADCC and ADCP assays showed that particularly neutrophils and macrophages from healthy donors, non-human primates and patients with neuroblastoma are able to kill neuroblastoma tumor cells efficiently with IgA3.0 ch14.18. (bmj.com)
Clinical2
- This report shows the characterization of the humoral response elicited after vaccination with 400 µg of antigen combined with 200 µg of VSSP in cancer patients representative of the Cuban real clinical practice setting. (researchsquare.com)
- We review clinical data on the benefit of RASi in primary and metastatic tumors and propose that, by activating immunostimulatory pathways, these inhibitors can enhance immunotherapy of cancer. (nutriforce.cn)
Promotes1
- Tumor-native ST6GAL1 promotes tumor cell behaviors such as invasion and resistance to cell stress and chemo- and radio-treatments. (nature.com)
Additionally1
- Additionally, TAMs in the hypoxic niches within the tumor are known to mediate resistance to several anticancer treatments and to promote cancer relapse. (nutriforce.cn)
Transporters1
- Fittingly, the abundance of the presynaptic vesicular neurotransmitter transporters VGLUT1 and VGAT was also decreased in the tumor. (bvsalud.org)
Human3
- IUE of BRAFV600E/AktDD in mice resulted in tumors with the morphological features of human GGs. (bvsalud.org)
- Characterization of the first fully human anti-TEM1 scFv in models of solid tumor imaging and immunotoxin-based therapy. (atsbio.com)
- Towards non-parametric diffusion-T1 characterization of crossing fibers in the human brain. (lu.se)
Radiation1
- Matthias Pinter1,2 and Rakesh K. Jain1,* 1Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA. (nutriforce.cn)
Composition1
- We present the first comparative characterization of ganglioside composition in anaplastic ganglioglioma vs. peritumoral and healthy brain tissues by combining mass spectrometry and thin-layer chromatography. (bvsalud.org)
Dominant2
- The dominant sphingoid base residue in ganglioside ceramides was sphingosine (d18:1), followed by eicosasphingosine (d20:1). (bvsalud.org)
- The adult mammalian nervous system has four dominant types of gangliosides: GM1, GD1a, GD1b, and GT1b. (jneurosci.org)
Cell2
- Dr. Battula discovered GD2 and GD3 Synthase as a unique marker to identify CSCs from primary breast tumors and cell lines. (mdanderson.org)
- The impact of this non-canonical extrinsic mechanism of ST6GAL1 on tumor cell pathobiology is not known. (nature.com)
Frequent1
- Gangliogliomas (GGs), composed of dysmorphic neurons and neoplastic astroglia, represent the most frequent tumor entity associated with chronic recurrent epileptic seizures. (bvsalud.org)
Plasma1
- 2:00 Increase in Plasma Ganglioside Content is Associated with Improved Quality of Life in Inflammatory Bowel Disease. (lipidsfatsoilssurfactantsohmy.com)
Tissues1
- Finally, we apply our method on mucin-type O-glycans, gangliosides, and site-specific compositional glycosylation data to reveal tissues and disease-specific glycan presentations. (omicsdi.org)
Primary2
- Dr. Battula is also interested in understanding the metabolic processes that regulate the expression of GD2 as well as the function of CSCs in primary tumors. (mdanderson.org)
- In addition, he is also interested in understanding the origin of CSCs in primary tumor. (mdanderson.org)
Brain1
- The timing of the genetic event and the specific gene involved during neurodevelopment will drive the nature and size of the lesion, whether it is a developmental malformation or a brain tumour. (bvsalud.org)
Content1
- Flow cytometric analysis of the tumour DNA content showed an index of 1.8 relative to normal peripheral blood lymphocyte DNA. (tmu.edu.tw)