Tumor associated fibroblasts. Medical search. Frequent questions

Thus, the APJ system in fibroblasts in the tumor microenvironment may be a promising therapeutic target. (spandidos-publications.com)
The tumor microenvironment consists of various cell types and fibroblasts in the tumor tissue, called cancer-associated fibroblasts (CAFs), which play pivotal role in tumor progression ( 7 , 8 ). (spandidos-publications.com)
The mutational inactivation of the TP53 gene in tumor cells has been reported to affect not only tumor cells but also the surrounding cells in the tumor microenvironment and to promote tumor-stromal activation and subsequent tumor growth ( 11 , 12 ). (spandidos-publications.com)
Background Cancer-associated fibroblasts (CAFs) are a major component of the non-small cell lung cancer (NSCLC) tumor microenvironment (TME). (bmj.com)
Cellular transformation to neoplasm, tumor formation, and progression require an inherent crosstalk between the tumor microenvironment and the tumor. (biomedcentral.com)
The tumor microenvironment or tumor stroma comprises various cell types, including cancer-associated fibroblasts (CAFs), immune cells, endothelial cells, and mesenchymal cells. (biomedcentral.com)
Stromal cells in the tumor microenvironment: accomplices of tumor progression? (nature.com)
activated fibroblast) is a cell type within the tumor microenvironment that promotes tumorigenic features by initiating the remodelling of the extracellular matrix or by secreting cytokines. (wikipedia.org)
Treatment resistance could be due to the tumour microenvironment, a desmoplastic stroma consisting of cancer-associated fibroblasts and tumour-infiltrating lymphocytes (TILs). (hal.science)
Conclusion In patients with resected left-sided pancreatic cancer, a tumour microenvironment characterized by a high CD4/CD3 lymphocyte ratio along with a low αSMA/vimentin ratio is correlated with poorer survival. (hal.science)
Tumor stroma has an active role in the initiation, growth, and propagation of many tumor types by secreting growth factors and modulating redox status of the microenvironment. (a-star.edu.sg)
Although PPARβ/δ in fibroblasts was shown to modulate oxidative stress in the wound microenvironment, there has been no evidence of a similar effect in the tumor stroma. (a-star.edu.sg)
Signals supporting CAF function are thus emerging as candidate therapeutic targets in the tumor microenvironment. (lu.se)
Newswise - Using mathematical models, researchers in the Integrated Mathematical Oncology (IMO) program at Moffitt Cancer Center are focusing their research on the interaction between the tumor and its microenvironment and the "selective forces" in that microenvironment that play a role in the growth and evolution of cancer. (newswise.com)
Cancer is a complex disease driven by interactions between tumor cells and the tumor's microenvironment," Anderson said. (newswise.com)
Stromal fibroblasts are a dominant but heterogenous population within the tumor microenvironment and therapeutic targeting of stromal subsets may have therapeutic utility. (elifesciences.org)
The plasticity and heterogeneity of fibroblasts in the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) has emerged as a key factor in determining tumor growth and therapeutic response. (elifesciences.org)
Immunology, tumour microenvironment & metastasis - is a technical and knowledge-based forum for cancer researchers at Lund University with specific interest in immunology, tumour microenvironment & metastasis. (lu.se)
The tumour microenvironment (TME) is defined as the environments supporting the heterogeneous tumours. (lu.se)
The tumour microenvironment is composed of both cellular components including cancer cells, immune cells, endothelial cells, fibroblasts, and many more cell types, as well as acellular components of the tissue including extracellular matrix components, metabolites, oxygen, acidity, and nutrition's among others. (lu.se)
The tumour microenvironment plays a fundamental role during tumorigenesis and holds great opportunities in future cancer therapies. (lu.se)

Cancer‑associated fibroblasts (CAFs) are pivotal in tumor progression. (spandidos-publications.com)
CAFs and normal fibroblasts differ with respect to the expression of various markers, such as fibrotic markers, growth factors, chemokines and cytokines ( 9 ). (spandidos-publications.com)
CAFs with tumor-promoting effects were usually activated and exhibited myofibroblast-like properties such as the upregulation of alpha-smooth muscle actin (α-SMA) ( 9 ). (spandidos-publications.com)
NSG data was analyzed with DESeq2 to identify genes that were differentially expressed in CAFs living in CTL-exclusive tumors. (bmj.com)
Results We identified 441 genes that were differentially expressed in CAFs residing in CTL-exclusive tumors compared to CAFs in CTL-inclusive tumors. (bmj.com)
Because activated fibroblasts in inflammatory conditions have similar characteristics as cancer-associated fibroblasts (CAFs) and CAFs contribute actively to the malignant phenotype, we believe that anti-fibrotic drugs have the potential to be repurposed as anti-cancer drugs. (biomedcentral.com)
However, co-culture in vitro experiments and co-implantation in vivo experiments showed that the combination of low doses of cisplatin (10 μM) and low doses of pirfenidone (0.5 mg/mL), in both CAFs and tumors, lead to increased cell death and decreased tumor progression, respectively. (biomedcentral.com)
Therefore, a combined therapy that targets both the tumor cell and the CAFs might lead to novel therapies in cancer. (biomedcentral.com)
CAFs have been found to be abundant in a tumour stroma. (wikipedia.org)
Myofibroblasts and fibroblasts make up CAFs. (wikipedia.org)
CAFs however, are derived from either normal fibroblasts, pericytes, smooth muscle cells, fibrocytes or mesenchymal stem cells These CAFs then go on to support tumour growth by secreting growth factors such as Vascular Endothelial Growth Factor (VEGF), Platelet Derived Growth Factor (PDGF) and Fibroblast Growth Factor (FGF) and other chemokines to stimulate angiogenesis and thus the growth of a tumour. (wikipedia.org)
Markers for CAFs are notably similar to those of surrounding tumour-associated cells but at the same time, display massive heterogeneity of behaviour, appearance and genotype. (wikipedia.org)
These CAFs arise from fibroblasts within the vicinity of the tumour that have been recruited by cancer derived growth factor. (wikipedia.org)
It is believed that most CAFs arise from differentiated resident fibroblast cells. (wikipedia.org)
It is unclear why normal fibroblasts transition into CAFs but it has been found that by adding transforming growth factor-β to fibroblasts in culture they start to display features of CAFs. (wikipedia.org)
Less common origin of CAFs is by differentiation of other tumor adjacent cells such as epithelial or endothelial cells, adipocytes, pericytes and smooth muscle cells. (wikipedia.org)
The aim of the study was to evaluate the prognostic value of TILs and cancer-associated fibroblasts (CAFs) in pancreatic cancer of the body and tail. (hal.science)
Here we investigated the interactions between CSCs and CAFs in mammary gland tumors driven by combined activation of Wnt/{beta}-catenin and Hgf/Met signaling in mouse mammary epithelial cells. (mdc-berlin.de)
Cancer-associated fibroblasts (CAFs) play a key role in promoting tumor growth, acting through complex paracrine regulation. (oncotarget.com)
We found that GTPCH was upregulated in breast CAFs and epithelia, and high GTPCH RNA was significantly correlated with larger high grade tumors and worse prognosis. (oncotarget.com)
MCF-7) with fibroblasts isolated from breast healthy skin (normal fibroblasts, NFs) or breast tumor stroma (cancer-associated fibroblasts, CAFs) [1]. (fupress.net)
This study was designed to deepen the knowledge of the role played notably by CAFs in promoting breast tumor cell migratory skill through the analysis of the expression/activity of downstream potential target molecules and of the contribution of paracrine signalings. (fupress.net)
These results provide new insights in understanding the role of CAFs in promoting tumor cell invasiveness and may help to devise new targeted therapeutic approaches. (fupress.net)
CAFs enhance tumor cell line MKN-45 migraton and invasion through upregulated TAGLN. (biomedcentral.com)
Here, we combine spatial transcriptomics and scRNA-Seq datasets to define the transcriptome of tumor-proximal and tumor-distal cancer-associated fibroblasts (CAFs) and link this to clinical outcome. (elifesciences.org)
In contrast, inflammatory CAFs were dominant within tumor-distal subsets and expressed complement components and the Wnt-inhibitor SFRP2. (elifesciences.org)
These findings demonstrate the extreme transcriptional heterogeneity of CAFs and its determination by apposition to tumor. (elifesciences.org)
While cancer-associated fibroblasts (CAFs) are increasingly appreciated as covering a spectrum of perturbed states, we lack a coherent understanding of their relationship-if any-with the steady-state fibroblast subtypes. (lu.se)
To address this, we here established two autologous CAF lines representing inflammatory CAFs (iCAFs) and myofibroblast CAFs (myCAFs) and compared them with already established interlobular- and lobular fibroblasts with respect to their origin and impact on tumor formation. (lu.se)
Methods: Primary breast tumor-derived CAFs were transduced to express human telomerase reverse transcriptase (hTERT) and sorted into CD105 low and CD105 high populations using fluorescence-activated cell sorting (FACS). (lu.se)

We show that mAb FAP5-DM1 combines excellent efficacy and tolerability and provides a first assessment of the mode of action of a novel drug candidate for tumor stroma targeting, thus encouraging further development toward clinical testing of this treatment paradigm. (aacrjournals.org)
Fibroblast activation protein (FAP) is a cell-surface protein expressed at low levels in most normal adult tissues, but over-expressed in common cancers, particularly on cancer-associated fibroblasts that form the tumor stroma, which is essential for growth 1 ,2 ,3 ,4 . (novartis.com)
These targeted drugs bind to markers or proteins over-expressed by certain tumors, or tumor-associated tissue, such as stroma. (novartis.com)
TGF-ß1 and IL-1 α produced by odontogenic tumors / cysts induced osteoclastogenesis directly in the osteoclast precursor cells and indirectly via increased RANKL induction in the stroma. (bvsalud.org)
GTP cyclohydrolase (GTPCH) expression for tetrahydrobiopterin synthesis in tumor stroma is implicated in angiogenesis and tumor development. (oncotarget.com)
To clarify the possible role of tumor-stroma paracrine interaction in the previously reported improvement of cancer cell migratory ability, cocultures were set up in presence of neutralizing antibodies against hepatocyte growth factor, transforming growth factor-β or basic fibroblast growth factor. (fupress.net)

Cancer-associated fibroblasts (CAF) stimulate tumor growth and metastasis. (lu.se)
While carcinoid tumors have a tendency to grow slowly, they have a potential for metastasis. (medscape.com)
Humanized mouse model of ovarian cancer recapitulates patient solid tumor progression, ascites formation, and metastasis. (rochester.edu)
Carcinoid tumors have high potential for metastasis. (medscape.com)
Metastasis is a complex prosess in which cancer cells leave the original tumour site and migrate to other parts of the body and establish a secondary tumour. (lu.se)

Normal fibroblasts aid in the production of components of the extracellular matrix such as collagens, fibres, glycosaminoglycans and glycoproteins and are therefore vital in tissue repair in wound healing. (wikipedia.org)
Its name derives from the the observation that it inhibited the growth of tumor cells and augmented the growth of normal fibroblasts. (bvsalud.org)

However, there is a paradigm shift in cancer research that considers tumors as abnormal organs, thereby acknowledging the key contribution to tumor progression provided by fibroblasts and other non-cancerous stromal cells that shape the tumor mechanical and biochemical ecosystem. (bist.eu)
I will provide an overview of our efforts in unveiling how TAFs contribute to tumor progression in major lung cancer subtypes and in identifying how can we target such contributions with new therapeutic strategies, including the development of novel preclinical models. (bist.eu)
Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis. (il-10.com)
High FAP expression on cancer-associated fibroblasts is generally associated with worse prognosis in solid tumors due to promotion of tumorigenesis and progression 4 ,5 ,6 ,7 . (novartis.com)
According to Alexander R. A. Anderson, Ph.D., chair of the IMO, mathematical models can be useful tools for the study of cancer progression as related to understandings of tumor ecology. (newswise.com)

Sahai E, Astsaturov I, Cukierman E, et al (2020) A framework for advancing our understanding of cancer-associated fibroblasts. (bmj.com)

Malignant epithelial cancers, the major cause of cancer morbidity and mortality, arise in organs composed of both epithelial and mesenchyme-derived stromal cells, such as fibroblasts, myofibroblasts, endothelial cells, pericytes, smooth muscle, and hematopoietic cells. (aacrjournals.org)

They mapped out the location of individual fibroblasts in the vicinity of the tumour and analysed their gene activity. (elifesciences.org)

In addition, xenografts of HCT116 cells with APJ‑suppressed fibroblasts showed accelerated tumor growth. (spandidos-publications.com)

No lymphoid hyperplasia or tissue necrosis were noted in liver, spleen, or lungs in mice receiving repeated inocula of IL-12-engineered fibroblasts. (umn.edu)
Se- IL-9, IL-13, IL-15, GM-CSF, interferon-, tumor necrosis rum samples showed elevated concentrations in the acute factor- (TNF-), RANTES, basic fibroblast growth factor phase of the illness and, more pronounced, in the long-last- ing convalescent phase. (cdc.gov)
The fibroblasts then produce hyaluronan and the cytokines interleukin (IL)-1 beta, IL-6, IL-8, IL-16, tumor necrosis factor (TNF) alpha, and CD4 ligand. (medscape.com)
The centre of the tuberculous granuloma may undergo caseous necrosis surrounded by activated macrophages, T-cells and fibroblasts. (ersjournals.com)

relied on tumour samples obtained from pancreatic cancer patients. (elifesciences.org)
Pilot study of fibroblast activation factor expression in recurrent/progressive pancreatic cancer and mesothelioma using [68Ga]Ga-Fibroblast Activation Protein Inhibitor (FAPI) -46 PET imaging. (who.int)
Expression of fibroblast activation protein in advanced pancreatic cancer and mesothelioma will be assessed on PET imaging. (who.int)

Genetic or pharmacologic inhibition of NOS1 reduced the growth of CXCL14-expressing fibroblasts along with their ability to promote tumor formation following coinjection with prostate or breast cancer cells. (lu.se)

Therefore, our results establish a role for fibroblast PPARβ/δ in epithelial-mesenchymal communication for ROS homeostasis. (a-star.edu.sg)
In 1963, Popper and co-workers described mesenchymal cells not related to sinusoids and later noted that fibroblast-like cells and matrix deposits were present in ABT-737 pontent inhibitor the region immediately surrounding proliferating bile ducts in biliary cirrhosis (3, 4). (healthyconnectionsinc.com)
Names applied to fibroblasts found in the portal region have included peribiliary fibrogenic cells unique from hepatic stellate cells as well as periductular fibroblasts and portal/periportal mesenchymal cells (16-18). (healthyconnectionsinc.com)
Methods The mRNA expressions of FGF23, MEPE and sFRP4 were detected in 8 TIO tumors (T1-T8), 5 other mesenchymal tumors(C1-C5), 2 normal bone tissues(B1-B2), 2 normal muscle tissues(M1-M2), blood clotting and necrostic tissue of bone in a patient of hypophospatemic osteomalacia but not TIO (P1) using RT-PCR. (magtechjournal.com)

We talk about right here the fibroblasts and myofibroblasts from the portal system, emphasizing brand-new data demonstrating these cells possess important jobs in liver organ fibrosis and various other Pdpn pathology, and highlighting guaranteeing areas for potential analysis. (healthyconnectionsinc.com)
These early observations were coincident with the recognition by Gabbiani and colleagues that fibroblast-derived -easy muscle actin (-SMA)-expressing myofibroblasts were the major matrix producing cells in wound healing (5), setting the stage for the study of PF as potential mediators of fibrosis. (healthyconnectionsinc.com)
Tumor-proximal fibroblasts comprise large populations of myofibroblasts, strongly expressed podoplanin, and were enriched for Wnt ligand signaling. (elifesciences.org)
For example, certain fibroblasts close to the tumour resemble the myofibroblasts present in healing wounds, while those at the periphery show signs of being involved in inflammation. (elifesciences.org)

In general, the presence and density of cancer associated fibroblasts (CAF) point towards a bad prognosis for the patient, and so, are pro-tumour. (wikipedia.org)

MicroRNA 5703 enriched in exosomes derived from HCT116 sh p53 cells inhibited APJ expression, and inhibition of miR‑5703 diminished APJ suppression in fibroblasts caused by cancer cells. (spandidos-publications.com)
Treatment with mAb FAP5-DM1 induced long-lasting inhibition of tumor growth and complete regressions in xenograft models of lung, pancreas, and head and neck cancers with no signs of intolerability. (aacrjournals.org)
GTPCH inhibition resulted in the attenuation of tumor growth and angiogenesis. (oncotarget.com)
Both siRNA-mediated and pharmacological inhibition of SCD1 impaired tumor cells migration. (fupress.net)
Selective targeting of tumor-proximal subsets, potentially combined with HIF-1α inhibition and immune stimulation, may offer a multi-modal therapeutic approach for this disease. (elifesciences.org)

The role of exosomes collected by ultracentrifugation were also analyzed as mediators of p53 expression in cancer cells and APJ expression in fibroblasts. (spandidos-publications.com)
APJ expression in fibroblasts co‑cultured with p53‑suppressed colon cancer cells (HCT116 sh p53 cells) was significantly lower than in control colon cancer cells (HCT116 sh control cells). (spandidos-publications.com)
They found overlapping expression patterns which supported the idea that there are transitional states and even identified pluripotency in some patients' activated fibroblasts (suggesting progenitor cells). (wikipedia.org)
The normal fibroblast cells receive a hormone signal from nearby cancer cells, indicating that it must become activated, and is thus classed as a CAF. (wikipedia.org)
X. laevis LG15 cloned adult injected sc with 10,000 15/0 tumor cells. (rochester.edu)
Other types of cell lines are also available in X. laevis including: fibroblasts lines of the different strains and LG clones, and a kidney cells line (A6). (rochester.edu)
Similarly, the colorectal cancer cells and human colon epithelial cells also experienced lower oxidative stress when co-cultured with fibroblasts depleted of PPARβ/δ expression. (a-star.edu.sg)
Due to the high-affinity of these agents for specific tumor cells or associated tumor tissue, surrounding healthy tissue is less affected. (novartis.com)
Odontogenic tumors / cysts comprise odontogenic epithelial cells and stromal fibroblasts , which originate from the developing tooth germ . (bvsalud.org)
Thus, we hypothesized that odontogenic epithelial cells of odontogenic tumors / cysts induce osteoclast formation, which plays potential roles in tumor / cyst outgrowth into the jawbone. (bvsalud.org)
Many tumors display intracellular heterogeneity, with subsets of cancer stem cells (CSC) that sustain tumor growth, recurrence, and therapy resistance. (mdc-berlin.de)
Background, Nomenclature, and Markers Website fibroblasts (PF) had been reported as specific cells as soon as 1961, when Carruthers and co-workers utilized light and electron microscopy to review the rat portal system after bile duct ligation (BDL) (1, 2). (healthyconnectionsinc.com)
In coimplantation xenografts, GTPCH in fibroblasts enhanced tumor growth, upregulating Ang-1 and alpha-smooth muscle actin mainly in fibroblast-like cells. (oncotarget.com)
GTPCH/Ang-1 interaction in stromal fibroblasts and activation of Tie2 on breast tumor cells could play an important role in supporting breast cancer growth. (oncotarget.com)
Thus, we investigated the influence of fibroblasts on the expression of Stearoyl- CoA desaturase 1 (SCD1), the main enzyme regulating membrane fluidity, as well as on the level and activity of its transcription factor, SREBP1, in breast cancer cells. (fupress.net)
Carcinoid tumors are of neuroendocrine origin and derived from primitive stem cells in the gut wall, especially the appendix. (medscape.com)
We used an integrated mathematical and experimental approach to investigate whether melanoma cells recruit, activate and stimulate fibroblasts to deposit certain proteins known to be pro-survival for melanoma cells," Anderson said. (newswise.com)
Fibroblasts, the most common connective tissue functioning in the extra cellular matrix, were known to be activated by and drawn to cancer cells. (newswise.com)
Furthermore, by developing a fibroblast stem cells (FSC)-enriched fibroblast focus model to mimic in vivo fibrogenic response, we demonstrated a dose-dependent increase in fibroblast focus formation and collagen production by primary lung fibroblasts treated with multi-walled carbon nanotube s (MWCNTs). (cdc.gov)
Not only do these wrap pancreatic tumours in a dense, protective layer, they also foster complex relationships with the cancerous cells: some fibroblasts may fuel tumour growth, while other may help to contain its spread. (elifesciences.org)
Being able to specifically eliminate pro-cancer fibroblasts requires a better understanding of the factors that shape the role of these cells, and how to identify them. (elifesciences.org)
A subset of orbital fibroblasts in the orbit can differentiate into mature, lipid-accumulating cells or de novo adipogenesis. (medscape.com)
Human ovarian tumor ascites fluids rapidly and reversibly inhibit T cell receptor-induced NF-κB and NFAT signaling in tumor-associated T cells. (rochester.edu)
T cells and stromal fibroblasts in human tumor microenvironments represent potential therapeutic targets. (rochester.edu)
Functional characteristics were assessed with respect to contractility in culture and interaction with tumor cells in mouse xenografts. (lu.se)
The tumors are neurofibromas, which develop from nerve sheaths and consist of mixtures of Schwann cells, fibroblasts, neural cells, and mast cells. (msdmanuals.com)
The tumor cells are CD34 and vimentin positive. (medscape.com)
Matrix metalloproteases (MMPs) are zinc-dependent proteinases that participate in extracellular matrix degradation 1-3 and favor the invasion and proliferation of tumor cells 4 . (bvsalud.org)

Reciprocal functional modulation of the activation of T lymphocytes and fibroblasts derived from human solid tumors. (rochester.edu)

The goal of this study was to investigate the potential anti-inflammatory effects of thymoquinone treatment on synovial fibroblasts. (eastjmed.org)
DISCUSSION AND CONCLUSION: Taken together, these results show that thymoquinone in high concentrations is able to play a beneficial role in TNF-α mediated signaling in rheumatoid arthritis synovial fibroblasts. (eastjmed.org)

Kilvaer TK, Khanehkenari MR, Hellevik T, Al-Saad S, Paulsen E-E, Bremnes RM, Busund L-T, Donnem T, Martinez IZ (2015) Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic Impact and Their Correlations with Tumor Molecular Markers. (bmj.com)
Schulze AB, Schmidt LH, Heitkötter B, et al (2020) Prognostic impact of CD34 and SMA in cancer-associated fibroblasts in stage I-III NSCLC. (bmj.com)
Cancer associated fibroblasts (CAF) have been shown to support and regulate CSC function. (mdc-berlin.de)

APJ‑suppressed fibroblasts treated with an antagonist or small interfering RNA showed myofibroblast‑like properties, including increased proliferation and migratory abilities, via accelerated phosphorylation of Sma‑ and Mad‑related protein 2/3 (Smad2/3). (spandidos-publications.com)
These researchers noticed fibroblast proliferation around recently shaped bile ductules and reported that fibroblasts from the diseased portal system had long procedures and had been often encircled by fibrils, including flexible fibres (1). (healthyconnectionsinc.com)
In cocultures, GTPCH expressing fibroblasts stimulated breast cancer cell proliferation and motility, cancer cell Tie2 phosphorylation and consequent downstream pathway activation. (oncotarget.com)
GTPCH interacted with Ang-1 in stromal fibroblasts and enhanced Ang-1 expression and function, which in turn phosphorylated tumor Tie2 and induced cell proliferation. (oncotarget.com)
When the researchers observed a disparity between grading schemes and tumor activity observed through imaging, they developed a mathematical model based on changes in cell appearance, proliferation and invasion rates. (newswise.com)
ZNF513 combined with KIF3C regulates gingival fibroblast proliferation, migration, and fibrosis response via the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK pathways. (nature.com)

TP53 is a significant tumor suppressor gene, and its somatic mutations are one of the most frequent alterations in ~50% of all human cancers, including colorectal cancer ( 10 ). (spandidos-publications.com)
Similarly, in 112 osteosarcomas who underwent exome or whole genome sequencing, another report found a median of 38 mutations per tumor. (biomedcentral.com)
A sensitive and quantitative assay using peptide nucleic acid-mediated real-time PCR was developed for detecting FGFR3 mutations in the urine samples and evaluated as a molecular marker for detecting intravesical recurrence of NMIBC in patients undergoing transurethral resection of bladder tumor. (elsevierpure.com)
FGFR3 mutations were detected in 53.3% (24/45) of primary tumor tissues, among which intravesical recurrence developed in 37.5% (9/24) of cases. (elsevierpure.com)
FGFR3 mutation in the primary tumor was not a significant prognostic indicator for recurrence, while the proportion of FGFR3 mutation (i.e. tumor cellularity was ≥11%) in the preoperative urine sediments was a significant indicator for recurrence in patients with FGFR3 mutations in the primary tumors. (elsevierpure.com)
FGFR3 mutations were detected in 78% (7/9) of postoperative urine samples from recurrent cases with FGFR3 mutations in the tumor, while no mutations were detected in the urine of 15 non-recurrent cases. (elsevierpure.com)
Urine cytology was negative in all cases with FGFR3 mutations in the primary tumors, while the sensitivity of cytological examination was as high as 56% (5/9) in cases showing wild-type FGFR3 in the primary tumors. (elsevierpure.com)
Desmoid tumors occur at a rate of 10-15% in patients with FAP, an autosomal inherited disease caused by germline mutations in the APC gene. (medscape.com)
In desmoid tumors, one of the two mutations usually occurs distal to the second beta-catenin binding/degradation repeat of the gene (3' to codon 1399). (medscape.com)

Characterising Mutational Spectra of Carcinogens in the Tumour Suppressor Gene TP53 Using Human TP53 Knock-in (Hupki) Mouse Embryo Fibroblasts. (who.int)

It causes various types of benign or malignant tumors that involve central or peripheral nerves and often causes pigmented skin macules and sometimes other manifestations. (msdmanuals.com)
There is no specific treatment, but benign tumors can be removed surgically, and malignant tumors (which are less common) can be treated with radiation therapy or chemotherapy. (msdmanuals.com)
Occasionally, they transform to malignant peripheral nerve sheath tumors. (msdmanuals.com)
The clinical differential diagnosis of a fibroma depends on its clinical presentation and location and includes giant cell fibroma, neurofibroma , peripheral giant cell granuloma , schwannoma, granular cell tumor, mucocele , and benign and malignant salivary gland tumors (eg, see Salivary Gland Neoplasms ). (medscape.com)

This process is similar to active inflammation with the main difference between these two processes being that, in cancer, the fibroblasts can't be deactivated which has led to tumours being referred to as "wounds that do not heal. (wikipedia.org)

Affected individuals carry a germ-line loss-of-function mutation of the MEN1 gene, and tumors arise after loss of the second allele. (johnshopkins.edu)
The fibroblast growth factor receptor (FGFR)-3 gene encodes a receptor tyrosine kinase that is frequently mutated in non-muscle invasive bladder cancer (NMIBC). (elsevierpure.com)
Specifically, elevated expression of HIF-1a and podoplanin predicted worse outcome while inflammatory gene expression correlated with increased survival, suggesting future interventions targeting proximal fibroblast populations to mitigate against PDAC. (elifesciences.org)
The main purpose of this study was to characterize the fate of cardiac fibroblasts (CFs) and the dynamic gene expression patterns in a model of cardiac pressure overload using scRNA-seq analysis. (hindawi.com)
[ 11 ] Desmoid tumors show biallelic APC mutation, with one change usually occurring distal to the second beta-catenin binding/degradation repeat of the gene (3' to codon 1399). (medscape.com)
In 15% of cases, this type is familial and related to a germline mutation in the SMARCB1 gene, a tumor suppressor gene located at 22q11.23, very close to the NF2 gene. (msdmanuals.com)

Trichofolliculomas are benign tumors of hair follicle origin. (medscape.com)

Distribution of carcinoid tumors. (medscape.com)
Signs and symptoms of carcinoid tumors vary greatly. (medscape.com)
Carcinoid tumors can be "nonfunctioning" presenting as a tumor mass or "functioning" i.e. producing several biopeptides causing carcinoid syndrome. (medscape.com)
Therefore, findings range from no tumor-related symptoms (most carcinoid tumors) to full symptoms of carcinoid syndrome (primarily in adults). (medscape.com)
[ 14 ] Due to their vague and intermittent symptoms, diagnosis of carcinoid tumors may be delayed, especially in children, in whom the tumor is rare and the diagnosis is unexpected. (medscape.com)
Carcinoid crisis can be the most serious symptom of carcinoid tumors and can be life-threatening. (medscape.com)
The etiology of carcinoid tumors is not known, but genetic abnormalities are suspected. (medscape.com)
Laboratory diagnosis of carcinoid tumors depends on the identification of the characteristic biomarkers of the disease. (medscape.com)
Signs and symptoms of carcinoid tumors vary greatly and depend on the tumor location and size as well as on the presence of metastases. (medscape.com)
If feasible, the treatment of choice for carcinoid tumors is surgical excision. (medscape.com)

Odontogenic tumors and cysts , arising in the jawbones, grow by resorption and destruction of the jawbones. (bvsalud.org)
However, mechanisms underlying bone resorption by odontogenic tumors / cysts remain unclear. (bvsalud.org)
They analyzed the role of MMP-2, MMP-8 and MMP-13 in radicular cysts, dentigerous cysts and keratocystic odontogenic tumors, and of MMP-1, MMP-7 and MMP-27 in keratocystic odontogenic tumors. (bvsalud.org)
In the studies analyzed, there was a significant positive immunoreactivity for metalloproteases in odontogenic lesions, particularly in keratocystic odontogenic tumors, a finding that may explain KCOT aggressiveness. (bvsalud.org)

Immunoglobulins against insulin-like growth factor 1 (IGF-1) receptors activate signaling in the orbital fibroblasts. (medscape.com)

The surgical technique may vary according to the type or location of the tumor. (medscape.com)

Immunostaining with vimentin, alpha smooth muscle actin, muscle actin, and desmin are helpful in distinguishing the tumors in the differential diagnosis of desmoid tumors. (medscape.com)

Basel, March 30, 2021 - Novartis has obtained exclusive worldwide rights to develop and commercialize therapeutic applications for a library of Fibroblast Activation Protein (FAP) targeting agents including FAPI-46 and FAPI-74, through an assignment agreement with iTheranostics, Inc., an affiliate of SOFIE Biosciences, Inc. The FAP assets were originally developed at the University of Heidelberg. (novartis.com)

However, the clinical significance of GTPCH expression in breast cancer is still elusive and how GTPCH regulates stromal fibroblast and tumor cell communication remains unknown. (oncotarget.com)

Anticipated technological breakthroughs will create numerous opportunities for determining genetic predisposition, detecting specific tumors, and monitoring biological response to cancer therapy. (aarkstore.com)
Additionally, evidence also exists for a genetic predisposition to desmoid tumors in FAP, independent of the APC mutation. (medscape.com)

Desmoid tumors are cytologically bland fibrous neoplasms originating from the musculoaponeurotic structures throughout the body. (medscape.com)

Scholars@Duke publication: Tumour suppressor genes and angiogenesis: the role of TP53 in fibroblasts. (duke.edu)

APJ suppression from a specific microRNA in cancer cell‑derived exosomes induced CAF‑like properties in fibroblasts. (spandidos-publications.com)
The present study was undertaken to determine the antitumor effects of an antibody-conjugate against fibroblast activation protein-α, a cell surface protease of activated tumor fibroblasts. (aacrjournals.org)
For scRNAseq, tumor tissues are digested, causing cell death, and the resultant transcriptomic profile is incomplete. (bmj.com)
The impact on cell death in vitro as well as tumor growth in a mouse model was determined. (biomedcentral.com)
Pleotropic functions (e.g. tumour-promoting and tumour-inhibiting) require cell plasticity. (wikipedia.org)
X. laevis is the only amphibian where true lymphoid tumors have been discovered and cell lines have been obtained opening new avenues for tumor biology and tumor immunity. (rochester.edu)
We generated immortalized wild-type (WT) and menin-null mouse embryo fibroblast (MEF) cell lines and evaluated their characteristics, including global expression patterns. (johnshopkins.edu)
Cell tracking analysis demonstrated that the CAF-mediated increase in tumor cell migration speed was reduced or abolished by neutralizing the above soluble factors. (fupress.net)
cell migration assay in vitro (fibroblasts with or without TAGLN siRNA interference). (biomedcentral.com)
Schwann cell versus fibroblast as the origin of the specific nerve sheath tumor: Observations upon normal nerve sheaths and neurilemomas in vitro. (wikidata.org)
Here the authors use innovative approaches to combine spatial profiling with single cell transcriptomics to define tumor-proximal populations of fibroblasts that predict clinical outcome. (elifesciences.org)
This may be due, in part, to a type of cell called fibroblasts. (elifesciences.org)
The myofibroblast is the cell considered to be responsible for the development of desmoid tumors (see Procedures). (medscape.com)
Vestibular Schwannoma A vestibular schwannoma (acoustic neuroma) is a Schwann cell-derived tumor of the 8th cranial nerve. (msdmanuals.com)
Cell-Free Tumor DNA Dominant Clone Allele Frequency Is Associated With Poor Outcomes in Advanced Biliary Cancers Treated With Platinum-Based Chemotherapy. (cdc.gov)

A novel antibody-maytansinoid conjugate, monoclonal antibody (mAb) FAP5-DM1, was developed to target a shared epitope of human, mouse, and cynomolgus monkey fibroblast activation protein-α, enabling preclinical efficacy and tolerability assessments. (aacrjournals.org)
Several radiolabeled fibroblast activation protein targeted inhibitors (FAPI) have been developed for molecular imaging and therapy. (mdpi.com)

The patient's tumor showed 68% reduction in positron emission tomography (PET) avidity, lasting 31 months after therapy initiation, when a solitary recurrence occurred, was resected, and treatment continued. (biomedcentral.com)

Targeted radioligand therapy is a type of precision medicine combining two key elements: a targeting compound, or ligand, and a radioactive isotope, causing DNA damage that inhibits tumor growth and replication. (novartis.com)
We observed two pathways for receptor activator of NF-κB ligand (RANKL) induction by keratocystic odontogenic tumor fluid the cyclooxygenase-2 (COX-2)/ prostaglandin E2 ( PGE2 ) pathway through interleukin-1 α ( IL-1 α) signaling and non-COX-2/ PGE2 pathway through TGF-ß receptor signaling. (bvsalud.org)

In 2017 Swedish researchers tried to classify molecularly distinct fibroblasts into groups depending on their differential expression of markers. (wikipedia.org)
TGF-ß in jaw tumor fluids induces RANKL expression in stromal fibroblasts. (bvsalud.org)
The expression changes associated with the loss of the tumor suppressor menin provide insights into the defective organogenesis observed during early embryonic development in Men1-null mouse embryos. (johnshopkins.edu)
TAGLN expression by QRT-PCR analysis after siRNA knockdown in fibroblasts. (biomedcentral.com)
TAGLN expression by Western blot analysis after siRNA knockdown in fibroblasts. (biomedcentral.com)
ZNF513 , a transcription factor, binds to KIF3C exon 1 and participates in the positive regulation of KIF3C expression in gingival fibroblasts. (nature.com)
Some studies about odontogenic cysts and tumors have been conducted to evaluate metalloprotease expression in these lesions. (bvsalud.org)

Clinical History of the Theranostic Radionuclide Approach to Neuroendocrine Tumors and Other Types of Cancer: Historical Review Based on an Interview of Eric P. Krenning by Rachel Levine. (thieme-connect.de)

We have tested paracrine delivery of IL-12 using autologous or allogeneic fibroblasts engineered to secrete high levels of IL-12 to treat established tumors. (umn.edu)
GTPCH may be an important mechanism of paracrine tumor growth and hence a target for therapy in breast cancer. (oncotarget.com)

Visual and semi-quantitative analysis will be undertaken on both 68Ga]Ga-FAPI-46 PET and [18F]FDG PET images to assess activity both at tumour sites and normal background tissue (including liver, bone, lung, kidneys). (who.int)

Weekly inoculations for 3 wk could also be used to effectively treat a day 4 sarcoma located intradermally in the opposite flank (80% protection using autologous fibroblasts), resulting in long-term protective antitumor immunity. (umn.edu)

Objective To evaluate the role of Fibroblast growth factor 23 (FGF-23), matrix extracellular phosphoglycoprotein (MEPE) and secreted Frizzled related protein 4 (sFRP4) in pathogenesis of Tumor induced osteomalacia (TIO). (magtechjournal.com)
In response to injury, myocardial fibroblasts show abnormal activation and secrete excessive extracellular matrix, resulting in chamber wall stiffness and diastolic dysfunction [ 5 ]. (hindawi.com)

TGF-β is known to control the activation of fibroblasts in inflammation. (wikipedia.org)

The FGF23 protein expressions were analyzed in 8 TIO tumors using Western blot. (magtechjournal.com)
7/8 TIO tumors expressed various FGF23 protein in Western blot. (magtechjournal.com)
p53-Associated Parkin-like cytoplasmic protein (Parc) short-interfering RNA (siRNA) alters p53 location and biology of Peyronie's disease fibroblasts. (rochester.edu)

To generate a holistic profile of CAF subtypes within NSCLC, and identify the subpopulation that promotes CTL exclusion, we have utilized the GeoMX® Digital Spatial Profiler (DSP) 14-17 , a state-of-the-art platform that allows for spatially resolved, high-plexed molecular profiling of intact tumor tissues. (bmj.com)
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized primarily by endocrine tumors of the parathyroids, anterior pituitary, and enteropancreatic endocrine tissues. (johnshopkins.edu)
FGFR3 mutation was examined in tumor tissues and serially taken pre- and postoperative urine sediments in 45 NMIBC patients with a median follow up of 32 months. (elsevierpure.com)

This structure is endowed with its very own lobular fibroblasts representing one out of two steady-state fibroblast subtypes-the other being interlobular fibroblasts. (lu.se)

In vivo treatment of tumors with the Hedgehog inhibitor vismodegib reduced CAF and CSC expansion, resulting in an overall delay of tumor formation. (mdc-berlin.de)

This course and the tendency for recurrence make the treatment of these relatively rare fibrous tumors challenging. (medscape.com)

MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 have been identified in odontogenic cysts, which suggests that MMPs play an important role in the growth of these tumors 9-10 . (bvsalud.org)

and colon fibroblasts, CCD‑18Co), resected human tissue samples of colorectal cancers, and immune‑deficient nude mouse xenograft models. (spandidos-publications.com)

The pre-treatment of FSPCre-Pparb/d−/− and Pparb/dfl/fl with antioxidant N-acetyl-cysteine prior DSS-induced tumorigenesis resulted in lower tumor load. (a-star.edu.sg)

Anatomy27

Organisms10

Diseases67

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes48

Disciplines and Occupations1

Information Science4

Health Care5

Microenvironment21

CAFs30

Stroma6

Metastasis5

Normal fibroblasts2

Progression5

Understanding of cancer-associated fibroblasts1

Endothelial cells1

Vicinity of the tumour1

Accelerated tumor growth1

Necrosis4

Pancreatic cancer3

Promote tumor1

Mesenchymal4

Myofibroblasts4

Prognosis1

Inhibition5

Cells28

Solid tumors1

Synovial fibroblasts2

Cancer-associated3

Proliferation6

Mutations9

Embryo fibroblasts1

Malignant4

Tumours1

Gene6

Benign tumors1

Carcinoid tumors10

Odontogenic tumors4

Orbital fibroblasts1

Location of the tumor1

Actin1

Therapeutic1

Regulates1

Genetic predisposition2

Neoplasms1

Angiogenesis1

Cell15

Activation protein2

Positron emission t1

Ligand2

Expression7

Clinical1

Paracrine2

FAPI1

Immunity1

Extracellular2

Inflammation1

Protein3

Tissues3

Subtypes1

Inhibitor1

Recurrence1

Cysts1

Colorectal1

Tumorigenesis1