Tumor associated antigens cd70. Medical search. Frequent questions

Accumulating research suggests that the tumor immune microenvironment (TIME) plays an essential role in regulation of tumor growth and metastasis. (biomedcentral.com)
Targeting tumor cells or the tumor microenvironment (TME) are the two major fundamental principles for antitumor therapies. (biomedcentral.com)
Different tumor types can also design their specific microenvironment by encouraging tumor angiogenesis and stimulating peripheral immune tolerance. (biomedcentral.com)
While GB tumors are frequently infiltrated by natural killer (NK) cells, these are actively suppressed by the GB cells and the GB tumor microenvironment. (frontiersin.org)
Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)
This study provides fundamental insight into the functional impact of CDK4 inhibition on cells in the tumor microenvironment, which is of high importance and interest to the field. (elifesciences.org)
ADI-270 is designed to home to solid tumors, with a highly specific targeting moiety for CD70 and an armoring technology of dominant negative TGF beta receptor to address immunosuppressive factors in the tumor microenvironment. (businesswire.com)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
The BrafV600E mutation has a direct role in driving cellular transformation but multiple studies suggest that it also indirectly modulates the tumor microenvironment. (cancer-pictures.org)
Thus more investigation is needed to better characterize the nature of the tumor microenvironment in melanoma and how BrafV600E inhibitors affect the function of infiltrating. (cancer-pictures.org)
We are also supplementing our basic TRuC-T cell format with innovative enhancements to combat the hostile tumor microenvironment in case certain cancer indications prove more resistant. (tcr2.com)
Costimulation occurs only in a PD-L1/2 rich tumor microenvironment upon TRuC and PD-1 ligation, resulting in a more targeted signal enhancement. (tcr2.com)
CAT-179 was resistant to TGFβ-mediated immunosuppression in vitro , indicating that the cells will be protected from TGFβ-mediated immune suppression in the tumor microenvironment. (pipelinereview.com)
SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment. (amedeo.com)

The ligand of CD70 is CD27. (biolegend.com)
In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. (thermofisher.com)
RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70. (thermofisher.com)
CD70 is also known as a ligand for CD27. (wikipedia.org)
CD27 and its ligand CD70 are involved in multiple aspects of T cell biology, including the costimulation and expansion of CD4+ and CD8+ T cells and differentiation to memory CD8+ T cells. (stemcell.com)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (elabscience.com)
The second involves a network of co-inhibitory and co-stimulatory molecules pathways such as CD80/CD86-CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4), inducible co-stimulator (ICOS)-ICOS ligand (ICOSL), programmed death-1 (PD-1), programme death ligand-1/2 (PD-L1/PD-L2), 4-1BB-4-1BB ligand (4-1BBL), CD40-CD154 ligand, OX40-OX40 ligand and CD27-CD70. (biomedcentral.com)

As a new promising cancer therapeutic approach, chimeric antigen receptor (CAR)-T cells represent a potential GC treatment. (biomedcentral.com)
As a therapeutic strategy for malignant diseases, chimeric antigen receptor (CAR) T cells have therapeutic potential in antitumor treatment [ 6 ]. (biomedcentral.com)
CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. (thermofisher.com)
Expression of CD70 on mDCs and pDCs is induced with Toll-like receptor (TLR) triggering and CD40 ligation. (wikipedia.org)
Receptor engagement can also cause reverse signaling through CD70. (wikipedia.org)
ADI-270 has demonstrated a highly differentiated profile stemming from its unique engineering, including targeting via a CAR that incorporates CD27, addition of dominant negative TGF beta receptor armoring, complimentary innate anti-tumor activity of the gamma delta 1 T cells and tissue tropism to solid tumors. (businesswire.com)
The LG.3A10 antibody reacts with CD27, a 45 - 55 kDa member of the tumor necrosis factor receptor superfamily. (stemcell.com)
Chimeric antigen receptor T (CART) cell therapy targeting the B cell specific differentiation antigen CD19 has shown clinical efficacy in a subset of relapsed/refractory (r/r) diffuse large B cell lymphoma (DLBCL) patients. (frontiersin.org)
Data from a second CAR-NK cell therapy construct engineered using the TAILWIND™ platform are presented in a poster titled "Allogeneic Natural Killer Cells Engineered to Express HER2-directed CAR, Interleukin-15 and TGFβ Dominant Negative Receptor Effectively Control HER2+ Tumors. (pipelinereview.com)
Catamaran Bio is developing novel, off-the-shelf chimeric antigen receptor (CAR)-NK cell therapies designed to treat a broad range of cancers, including solid tumors. (pipelinereview.com)
There is an unmet need to develop novel therapies for refractory/relapsed MM. In the past few years, chimeric antigen receptor (CAR)-modified T cell therapy for MM has shown promising efficacy in preclinical and clinical studies. (biomedcentral.com)
Chimeric antigen receptor (CAR) T cell therapy has emerged as a novel immunotherapy which modifies T cells with CAR, an artificial fusion protein that incorporates an extracellular antigen recognition domain, a transmembrane domain, and an intracellular domain including costimulation and signaling components [ 4 , 5 ]. (biomedcentral.com)

Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)

In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)
CD70 on activated antigen presenting cells (APC) including dendritic cells and B cells binds to CD27 on T lymphocytes and provides costimulatory signals. (wikipedia.org)
It is therefore suggested that anti-CD70 antibodies might be a possible treatment for CD70 positive lymphomas as normal lymphocytes have low CD70 expression. (wikipedia.org)
CD4 Phenotypes Are Associated with Reduced Expansion of Tumor-Infiltrating Lymphocytes in Melanoma Patients Treated with Adoptive Cell Therapy. (amedeo.com)

CD70 is expressed on activated T, B and NK cells, activated plasmacytoid dendritic cells (pDCs), and chronic B cell lymphocytic leukemia and large B cell lymphomas. (biolegend.com)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
Dendritic cells (DC) are responsible for initiating all antigen-specific immune responses. (aacrjournals.org)
Upon completion of this activity, the participant should understand the critical roles of dendritic cells in guiding host immune responses, and the details of how they mature, process, and present antigens. (aacrjournals.org)
Cross-presentation of cell-associated antigen by bone marrow-derived dendritic cells (BMDCs) was determined by CD8+ T cell proliferation assays in vitro and in vivo. (soton.ac.uk)
A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells. (amedeo.com)

CRISPR Therapeutics continues to enroll and dose patients in two independent Phase 1 clinical trials assessing the safety and efficacy of CTX130, the Company's wholly-owned allogeneic CAR-T investigative therapy targeting CD70 for the treatment of both solid tumors and certain hematologic malignancies. (crisprtx.com)
CTX130, a wholly-owned program of CRISPR Therapeutics, is a healthy donor-derived gene-edited allogeneic CAR T investigational therapy targeting Cluster of Differentiation 70, or CD70, an antigen expressed on various solid tumors and hematologic malignancies. (crisprtx.com)
As a result, more than five CAR-T cell products have been used clinically in the treatment of hematologic malignancies but not yet for solid tumors [ 8 ]. (biomedcentral.com)
ARGX-110 is a CD70-specific antibody that is currently under investigation for the treatment of hematological malignancies. (wikipedia.org)
Data supporting Catamaran's lead program, CAT-248, will be presented in a poster titled "Engineering CD70-directed CAR-NK cells for the Treatment of Hematological and Solid Malignancies. (pipelinereview.com)
These results demonstrate the potential for targeting CD70 with CAR-NK cell therapy for the treatment of AML, RCC, and other CD70-positive malignancies while overcoming fratricide issues by engineering with a non-viral transposon delivery system in combination with CRISPR/Cas9 editing. (pipelinereview.com)

A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN . (nih.gov)
CD70, also known as CD27L, is a 50 kD type II transmembrane glycoprotein and member of the tumor necrosis factor superfamily. (biolegend.com)
BCMA, a member of the tumor necrosis factor (TNF) superfamily, is exclusively expressed in a subpopulation of B cells, normal plasma cells, and malignant plasma cells. (biomedcentral.com)
A tumor necrosis factor superfamily member that plays a role in the regulation of B-LYMPHOCYTE survival. (rush.edu)

However, this finding has triggered further interest in utilising tumour-specific MHC-II to harness sustained anti-tumour immunity through the activation of CD4 + T helper cells. (portlandpress.com)
Thus, their reactivation represents an attractive way to unleash anti-tumour immunity. (portlandpress.com)
The adaptive immune system, discovered by Paul Ehrlich, involves the production of circulating antibodies that can provide long lasting, systemic immunity that is specific to antigens expressed by a given pathogen. (aacrjournals.org)
Invariant natural killer T (iNKT) cells are CD1d-restricted T cells, which respond rapidly to antigen recognition and promote development of anti-tumor immunity in many tumor models. (biomedcentral.com)
B-RafV600E inhibitors have been suggested to promote tumor regression with the help of host immunity but this hypothesis has not been examined directly in detail. (cancer-pictures.org)
Supporting this result agonistic CD40 antibody was sufficient to evoke anti-tumor immunity and suppress tumor growth in tumor-bearing mice. (cancer-pictures.org)
Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity. (amedeo.com)
In addition, whereas weak pre-existing immunity did not alter the protective thresholds of the vaccine-specific T cell response following subsequent immunization with CMV-based vaccine vectors, strong pre-existing immunity inhibited the development of vaccine-induced T cells and their control on tumor progression. (bmj.com)

The crosstalk between pro-tumorigenic immune cells, stromal cells, and cytokines helps to establish the pre-metastatic niche for disseminated circulatory tumor cells and facilitates metastasis. (biomedcentral.com)
While tumor expansion, contact-dependent or independent crosstalk between tumor and TIME affects the production of various cytokines that help in the polarization of antitumor immune response in the immunosuppressive TIME. (biomedcentral.com)
CD70 expression on T and B cells is stimulated through triggering of T and B cell receptors and can be upregulated by cytokines such as IL-1α, IL-2, IL-12, GM-CSF and TNF-α, while IL-4 and IL-10 can decrease CD70 expression. (wikipedia.org)
In our preclinical studies, we showed that TC-510 has enhanced early TCR downstream signaling, significantly increased proliferation, prevented exhaustion upon repeated antigen stimulation, augmented the growth and effector cytokines and enhanced the efficacy of the TRuCs against PD-L1 overexpressing tumors. (tcr2.com)

The cellular and molecular nature of the TIME influences cancer progression and metastasis by altering the ratio of immune- suppressive versus cytotoxic responses in the vicinity of the tumor. (biomedcentral.com)
Ongoing research investigates mechanisms invoked by cancer cells to abrogate MHC-I expression and attenuate anti-tumour CD8 + cytotoxic T cell response. (portlandpress.com)
There is also a need for rational combinations beyond interleukin (IL)-2 and programmed death (PD)-1/ cytotoxic T-lymphocyte-associated antigen (CTLA)-4 immune checkpoint blockade and to combat exhaustion and restore costimulatory functions, e.g., with gene-engineered or pharmacologic agent-treated TILs. (biomedcentral.com)
Engineered cells were highly cytotoxic against multiple CD70-positive tumor cells lines derived from renal cell carcinoma (RCC) and acute myeloid leukemia (AML). (pipelinereview.com)

Tumor immunotherapy is a new kind therapy that used immunological principles and methods to activate a patient's own immune system and enhance the patient's anti-tumor immune response, which inhibits tumor growth [ 5 ]. (biomedcentral.com)
Fig. 4: A lower level of CAR-mediated TROG-antigen expression was associated with improved clinical response to CAR-NK cell-based immunotherapy. (nature.com)
To determine if the improved response to treatment in the absence of iNKT cells was independent from the immunotherapy employed, 4T1-tumor bearing WT and iNKT −/− mice were treated with local radiotherapy in combination with antibody-mediated CD137 co-stimulation. (biomedcentral.com)
This study is looking at the effectiveness of combining a PARP inhibitor called niraparib and an immunotherapy called dostarlimab for treating people with an inherited BRCA mutation (found with genetic testing) or a tumor mutation (found through tumor testing) who have breast, pancreatic, ovarian, fallopian tube or primary peritoneal cancer that is metastatic or advanced and cannot be removed by surgery (unresectable). (facingourrisk.org)
However, not all patients respond to immunotherapy, acquired resistance remains a challenge, and responses are poor in certain tumors which are considered to be immunologically cold. (biomedcentral.com)
Various immunotherapy tumor-targeting schemes. (technologynetworks.com)
Retargeting IL-2 Signaling to NKG2D-Expressing Tumor-Infiltrating Leukocytes Improves Adoptive Transfer Immunotherapy. (amedeo.com)
Defined immune thresholds for tumor protection and the factors affecting such thresholds have not well been investigated in cancer immunotherapy. (bmj.com)

On the preclinical front, we are prioritizing the development of ADI-270 as our lead preclinical candidate in renal cell carcinoma and other solid tumor indications. (businesswire.com)
Adicet has reprioritized its preclinical pipeline to focus on the development of ADI-270 as its lead preclinical candidate for renal cell carcinoma, with potential in other solid tumor indications. (businesswire.com)
PAVO is an open-label Phase II study investigating if the study drug, a PARP inhibitor called niraparib (Zejula), is safe and effective for certain people who have been diagnosed with an advanced solid tumor with either an inherited or tumor PALB2 mutation. (facingourrisk.org)
As of the June 30, 2021 data cutoff date, we have observed clinical activity in all three mesothelin-expressing solid tumor types treated, a 31% Overall Response Rate (ORR) in patients infused with gavo-cel following lymphodepletion, and four RECIST partial responses (PRs) (3 confirmed and 1 unconfirmed PRs). (tcr2.com)

B7H3 targeted treatment has shown preliminary benefits for patients with tumors and is being evaluated by numerous ongoing clinical trials. (biomedcentral.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
Tumour-specific expression of MHC-I and MHC-II has been associated with improved patient survival in most clinical studies. (portlandpress.com)
Vorsetuzumab mafodotin is a CD70-targeted antibody-drug conjugate that started clinical trials for renal cell carcinoma. (wikipedia.org)
However, the clinical application of tumor-infiltrating γδ T cells has certain limitations. (explorationpub.com)
In clinical practice, a key challenge for generating TIL products is the accessibility, quantity, and quality of tumor tissue in the era of neo-adjuvant therapy. (biomedcentral.com)
Based on interim data readouts from patients in dose escalation in our Phase 1/2 clinical trial, gavo-cel has demonstrated consistent clinical benefit, with almost every patient experiencing tumor regression (15/16) and a 81% disease control rate (DCR). (tcr2.com)
We are developing a TRuC-T cell targeting CD70 due to its versatility as a tumor target, where it is expressed in blood cancers and solid tumors, and clinical validation. (tcr2.com)

These results demonstrate that NK cells engineered via the TAILWIND™ platform have a favorable pharmacologic profile and the potential for treatment of solid tumors. (pipelinereview.com)

CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. (wikipedia.org)

ALLO-715 is an allogeneic CAR T AlloCAR T™ cell therapy that targets the B-cell maturation antigen (BCMA) for the treatment of patients with relapsed/refractory multiple myeloma. (cellectis.com)
Several antigens have been used as targets for CAR-T cell therapy against MM, including B cell maturation antigen (BCMA), CD19, CD138, signaling lymphocytic activation molecule 7 (SLAM7), and immunoglobulin light chains. (biomedcentral.com)
Two main advantages of BCMA as an antigen for CAR-T therapy are the potential reduction of on-target/off-tumor toxicity and the lack of antigen-dependent reduction in CAR-T cell expansion [ 16 ]. (biomedcentral.com)
A potential disadvantage of BCMA is that soluble BCMA can be released or shed from tumors into the the surrounding tissues and into the circulation. (biomedcentral.com)

The anti-tumor effects of this CAR-T cell were finally investigated in vitro and in vivo. (biomedcentral.com)
Fig. 3: Impact of TROG-antigen acquisition on CAR-NK cell phenotype and function in vivo. (nature.com)
Taken together our results establish the critical role of immune-related changes with key contributions for CD40L and IFNγ signaling in the anti-tumor responses brought on in vivo by BRafV600E inhibitors. (cancer-pictures.org)
CAT-179 showed potent anti-tumor activity in vivo against a xenografted HER2+ N87 gastric cancer cell line and led to a significant survival benefit in tumor-bearing mice. (pipelinereview.com)

Fig. 1: CAR19-mediated trogocytosis in NK cells cocultured with CD19 + tumor targets. (nature.com)
To overcome these hurdles, Molecular Partners designed MP0533, a novel tetra-specific T cell-engaging, half-life extended DARPin, which simultaneously targets CD33, CD123 and CD70, as well as CD3 on T cells. (afternoonheadlines.com)
Our most advanced program, gavo-cel, targets tumors that express the protein mesothelin, including ovarian cancer, non-small cell lung cancer, malignant pleural/peritoneal mesothelioma, and cholangiocarcinoma. (tcr2.com)
We are focused on the discovery and validation of novel targets to broaden the reach of TRuC-T cells in solid tumors and hematologic cancers. (tcr2.com)

According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)
Similarly mice engrafted with a melanoma cell line and treated with the vemurafenib analogue PLX4720 also exhibited increased T cell infiltration in tumors and responsiveness to antigens (18 22 The anti-tumor effects of PLX4720 in this engraftment model was particularly dependent on CD8 T cells and could be enhanced by CD137 agonistic mAb treatment suggesting that BrafV600E inhibitors can sensitize tumors to certain immunotherapies (22). (cancer-pictures.org)

In addition to blocking anti-tumor immune responses these immunomodulatory cells can also promote tumor growth and metastasis through secretion of angiogenic factors (e.g. (cancer-pictures.org)

Glioblastoma (GB) is the most frequent malignant primary brain tumor in adults, without any curative treatment options available at present. (frontiersin.org)
This unique mode of action is designed to enable avidity-driven, T cell-mediated killing of leukemic stem cells and malignant blast cells, which commonly co-express at least two of the three target antigens, while preserving a therapeutic window that minimizes damage to healthy cells. (afternoonheadlines.com)
While its expression in normal tissues is low, mesothelin is highly expressed in a wide range of solid tumors, and it plays an active role in determining how malignant and/or aggressive tumors are. (tcr2.com)

The effects of antibody-mediated blockade of CD1d on DC number and phenotype, priming of anti-tumor T cells, and tumor response to treatment with local radiotherapy and anti-CTLA-4 antibody were evaluated. (biomedcentral.com)

In our preclinical studies, we showed that TRuC-T cells targeting CD70 had an improved memory phenotype and significant anti-tumor efficacy with no evidence of fratricide. (tcr2.com)
We have now shown preclinical efficacy in multiple xenograft models with two differentiated CAR-NK cell therapies engineered with the functional attributes necessary for durable efficacy in solid tumors and manufactured using an efficient non-viral cell engineering system. (pipelinereview.com)

PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma. (amedeo.com)

The clonal heterogeneity and lack of single AML-specific target antigens represent major challenges for the development of targeted immune therapies for AML. (afternoonheadlines.com)

In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. (elabscience.com)

While these cells show some features of exhaustion, they maintain high proliferative potential and are able to both self-renew and replenish populations of exhausted effector T cells that mediate control in chronic viral infections and tumors. (acir.org)
Adoptive T Cell Therapy with IL-12-Preconditioned Low-Avidity T Cells Prevents Exhaustion and Results in Enhanced T Cell Activation, Enhanced Tumor Clearance, and Decreased Risk for Autoimmunity. (amedeo.com)

Fig. 2: Impact of antigen-induced self-engagement on CAR-NK effector cell phenotype and function. (nature.com)
The magnitude, kinetics and phenotype of the circulating tumor-specific CD8 + T cell response were determined. (bmj.com)

Apoptotic cells treated with DN-MFG-E8-Fc protein resulted in upregulation of costimulatory molecules, CD86 and CD70, when BMDCs were deficient for the inhibitory Fc?R, Fc?RIIb. (soton.ac.uk)

CD70 acts as a costimulatory molecule and plays an important role in the regulation of the immune system activation, specifically by improving T-cell and B-cell activation, proliferation and survival, leading to a more efficient immune response. (wikipedia.org)

High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. (thermofisher.com)

Also, CD70 can be induced on NK cells upon stimulation with IL-15. (wikipedia.org)
Successful TIL therapy starts with the identification, enrichment, stimulation, and expansion of potent tumor-reactive T cells. (biomedcentral.com)

AACR 2023 - We presented early findings from the Phase 1 TRAVERSE trial evaluating the safety, tolerability, and activity of ALLO-316, an investigational AlloCAR T™ product candidate for the treatment of CD70 positive advanced or metastatic clear cell renal cell carcinoma (RCC). (allogene.com)

Decreasing the dose of the virus increased IFNγ production by TP cells, suggesting that higher antigen loads led to the generation of TP cells with repressed effector functions. (acir.org)

It has been reported that B7-H3 preferentially overexpressed in various tumors but low expression in normal tissues [ 12 ]. (biomedcentral.com)

For instance tumors treated with BrafV600E inhibitors displayed increased T lymphocyte infiltration and expression of melanoma antigens MHCI and PDL1 expression (17-21). (cancer-pictures.org)

Here we describe a novel mechanism of tumor immune escape mediated by iNKT cells that limit priming of anti-tumor T cells by controlling DC in tumors and draining lymph nodes. (biomedcentral.com)

CD70 costimulates T cell proliferation and differentiation. (biolegend.com)
In addition to its role in T-cell activation and proliferation, CD70 also plays a role in the regulation of B-cell activation and differentiation. (wikipedia.org)
This overexpression of CD70 in cancer cells has been shown to promote cell proliferation and survival, and to inhibit apoptosis, leading to the development and progression of the cancer. (wikipedia.org)

Tumor-infiltrating immune cells are an important component of the TIME and are a significant predictor of cancer patients' survival. (biomedcentral.com)
During metastasis, tumor-derived exosomes help in the requirement and arrangement of immunosuppressive immune cells for favorable premetastatic niche formation and growth of metastases. (biomedcentral.com)
In physiological condition the expression of CD70 on immune cells is transient and tightly controlled. (wikipedia.org)
Optimizing Flow Cytometric Analysis of Immune Cells in Samples Requiring Cryopreservation from Tumor-Bearing Mice. (amedeo.com)

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape. (nature.com)

Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
CD70 reverse signaling activates the phosphatidylinositol-3 kinase (PI3K) and MAP kinase signaling pathways, leading to the activation of various transcription factors and the expression of genes involved in cell growth and survival. (wikipedia.org)
We here determined using CMV as a vaccine platform whether critical thresholds of vaccine-specific T cell responses can be established that relate to tumor protection, and which factors control such thresholds. (bmj.com)

These tumors and accessories represent the hallmark characteristics that support tumor progression and lead to metastasis. (biomedcentral.com)
The ratio of pro- to antitumor immune populations in the TIME plays a critical role in the regulation of tumor progression and metastasis. (biomedcentral.com)

The compelling conclusion that proliferative exhausted T cells are associated with response in HPV+ head and neck cancer is supported by the cohort of 14 patients with paired tumor and adjacent normal tissue and rigorous bioinformatic analysis of nearly 50,000 single CD3+ T cell transcriptomes. (elifesciences.org)

ZUG, Switzerland and BOSTON, Sept. 28, 2022 (GLOBE NEWSWIRE) -- CRISPR Therapeutics (Nasdaq: CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, today announced that the U.S. Food and Drug Administration (FDA) granted Regenerative Medicine Advanced Therapy (RMAT) designation to CTX130™, the Company's wholly-owned allogeneic CAR T cell therapy targeting CD70, for the treatment of Mycosis Fungoides and Sézary Syndrome (MF/SS). (crisprtx.com)

Together, our findings suggest a promising role for P-Tex cells in the prognosis of patients with HPV-positive HNSCC by providing modest but persistent anti-tumor effects. (elifesciences.org)
The safety profile of gavo-cel continues to be generally well tolerated with a manageable adverse event profile with no patients experiencing on-target, off-tumor toxicities. (tcr2.com)

The interaction between CD27 and CD70 leads to the recruitment of intracellular adaptor proteins, such as TRAF2 and TRAF5, which then activate signaling pathways, including the NF-κB and JNK pathway. (wikipedia.org)

Anatomy26

Organisms8

Diseases36

Chemicals and Drugs126

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes37

Disciplines and Occupations1

Information Science3

Health Care3

Microenvironment16

LIGAND8

Receptor12

Chimeric1

Lymphocytes7

Dendritic cells6

Malignancies6

Superfamily4

Immunity8

Cytokines4

Cytotoxic4

Immunotherapy8

Solid tumor4

Clinical8

Treatment of solid tumors1

Cluster of Differentiat1

BCMA4

Vivo4

Targets4

Immunotherapies2

Growth and metastasis1

Malignant3

Antibody1

Efficacy2

Inhibits tumor growth1

Target antigens1

CD401

Exhaustion2

Phenotype2

Protein1

Costimulatory1

Ligation1

Stimulation2

Renal cell carc1

Effector1

Expression in normal tissues1

Melanoma1

Lymph nodes1

Proliferation3

Immune cells4

Regulate1

FACTORS3

Progression2

Cohort1

20221

Patients2

Intracellular1