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  • immune responses
  • In particular, in the elimination phase, cells of the innate and adaptive immune responses may eradicate the developing tumor and protect the host from tumor formation. (asm.org)
  • ref. 22 ) can alter the immunosuppressive milieu and aid in the initiation of antigen-specific immune responses ( 17 , 18 ). (aacrjournals.org)
  • However, recent findings suggest that combination of reovirus-mediated oncolysis and host immune responses is necessary to achieve efficient tumor regression associated with this virotherapy ( 29 ). (aacrjournals.org)
  • We show that therapeutic administration of reovirus overrides tumor-associated antigen presentation abnormalities before initiating tumor-specific adaptive immune responses. (aacrjournals.org)
  • Immune responses targeting these proteins could thus result in a limited or no generation of antigen-loss variants and, therefore, they may efficiently control in vivo tumor growth, thus meeting the requirements for an ideal TAA set forth above. (aacrjournals.org)
  • The paradoxical coexistence of spontaneous tumor antigen-specific immune responses with progressive disease in cancer patients furthers the need to dissect the molecular pathways involved in tumor-induced T cell dysfunction. (nih.gov)
  • The gp75 antigen presented by HLA-A31 may therefore constitute a useful immune target for specific treatment of patients with melanoma, since both antibody- and T cell-mediated immune responses can be generated against this antigen. (rupress.org)
  • antibody
  • Consistent with this train of thought, the targets of approved antibody therapies are predominantly extracellular antigens ( 1 ). (frontiersin.org)
  • molecule
  • Traditionally, immune checkpoint molecule is not included in the tumor antigens. (hstalks.com)
  • In the presence of the relevant antigen-positive cell line, each respective DART molecule was able to promote T-cell proliferation and cytokine release in a HER2 or EphA2-dependent manner. (aacrjournals.org)
  • The present and previous studies indicated that TIL586 recognized an antigen expressed on most melanoma and normal melanocytes in the context of the HLA-A31 molecule. (rupress.org)
  • molecules
  • By contrast, small molecules have been used to target those intracellular antigens with a functionality that is suitable for drug screening. (frontiersin.org)
  • Co-culturing of a CD137/NF-κB reporter cell line with tumor lines expressing HER2 or EphA2 revealed tumor antigen-dependent CD137 pathway activation by HER2 x CD137 and EphA2 x CD137 DART molecules, respectively. (aacrjournals.org)
  • mice
  • Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin. (pubmedcentralcanada.ca)
  • B ) Mouse Spas-1 expression in normal versus tumor prostate: the level of Spas-1 expression was determined in a panel of normal prostates and primary TRAMP tumors from 21- and 27-week-old mice. (nih.gov)
  • expression
  • Spas-1 expression was increased in advanced primary TRAMP tumors. (nih.gov)
  • Spas-1 expression is not restricted to the prostate but is increased in older TRAMP tumors. (nih.gov)
  • The clinical potential of these antigens is hampered by their limited expression in ALL patients or by their restricted presentation by nonprevalent HLA alleles. (aacrjournals.org)
  • Clinical
  • Unique TAAs are now being frequently found in several human tumors, although their use in clinical trials is difficult for the time required to characterize unique TAAs at a single patient level ( 8 , 9 , 13 ). (aacrjournals.org)
  • Tolerance
  • Significant improvements may result from the selection of the appropriate tumor-specific target antigen (to overcome the peripheral immune tolerance) and/or the development of immunization strategies effective at inducing a protective immune response. (asm.org)
  • novel
  • AbbVie leverages its expertise across multiple technology platforms to identify novel antigens and approaches needed to target them. (abbvie.com)