Tumor antigen induce antitumor immune responses antigen of tumor. Medical search. Frequent questions

In hematological malignancies, tumor-derived EVs might reprogram the bone marrow environment, suppress antileukemic immunity, mediate drug resistance and interfere with immunotherapies. (nature.com)
EVs collected from the serum of leukemic samples might correlate with disease stage, drug-/immunological resistance, or might correlate with antileukemic immunity/immune response. (nature.com)
Here, we illustrated that myeloid cells in K14HPV16/H2b mice possess potent immunosuppressive activity toward antigen-presenting cells and CD8 + T cells, dampening antitumor immunity. (nih.gov)
These results established immunosuppressive myeloid cells in lymphoid organs as an HPV + cancer-induced means of circumventing tumor immunity that will require targeted abrogation to enable the induction of efficacious antitumor immune responses. (nih.gov)
We describe two features of a murine model of transitional cell carcinoma, MB49, that render it an attractive in vivo model with which to study the effect of IL-10 on tumor immunity. (jefferson.edu)
Furthermore when tumor-induced IL-10 is removed, type 1 immunity is restored and tumors are completely rejected in up to 40 percent of animals. (jefferson.edu)
In contrast, those studying IL-10 in tumor systems by other means consistently reported that IL-10 inhibits anti-tumor immunity. (jefferson.edu)
We show that the disparate effects of IL-10 on tumor immunity are indeed due to the different modes of IL-10 production in the various studies. (jefferson.edu)
In summary, our studies clearly demonstrate that IL-10 inhibits anti-tumor immunity. (jefferson.edu)
Chimeric antigen receptor (CAR) T-cell therapy mediates antigen-dependent and -independent antitumor effects, and CAR T-cell activation of host antitumor immunity is critical for productive solid tumor CAR T immunotherapy, according to findings from laboratory studies presented by Christine E. Brown, PhD, at the virtual American Association of Cancer Research (AACR) Annual Meeting 2021. (targetedonc.com)
Findings from the analyses show that CAR T-cell may be able to transform the tumor microenvironment to elicit anti-tumor immunity in solid tumors. (targetedonc.com)
Brown, the deputy director of the T cell Therapeutic Research Laboratory at Beckman Research Institute of City of Hope, and her colleagues analyzed the role of the endogenous immune system in productive CAR T-cell responses and if CAR T cells can promote endogenous immunity in mouse models of glioblastoma treated with CAR T-cell therapy. (targetedonc.com)
This line of investigation inspired Darya Alizadeh, PhD, another investigator on the case report, to look at CAR T therapy and host antitumor immunity in co-culture assays. (targetedonc.com)
The cured mice exhibited host antitumor immunity and rejected antigen negative tumors after CAR T-cell therapy, which suggested the investigators were inducing new CAR T-cell responses or tumor reactivity. (targetedonc.com)
In line, B cells are closely associated with CD8 + cytotoxic T cells, which are important in antigen-specific immunity against tumors. (medjouel.com)
Alexandra Gabriela Barros Ferreira defends her Ph.D. thesis "Restoring antitumor immunity with dendritic cell reprogramming strategies" on Friday, 17 November, 2023. (lu.se)
My Ph.D. studies have focused on restoring anti-tumor immunity with dendritic cell reprogramming strategies. (lu.se)
They can inhibit the growth of tumor cells, kill them via phagocytosis, and promote anti-tumor immunity. (frontiersin.org)
We studied the in vivo requirement of cross-talk between cDCs and pDCs for eliciting antitumor immunity against in situ released tumor antigens in the absence or presence of the Toll-like receptor (TLR) 9 agonist CpG. (pasteur.fr)
The present study shows that cDCs are indispensable for cross-presentation of ablation-released tumor antigens and for the induction of long-term antitumor immunity. (pasteur.fr)
Thus, monocyte depletion by gemcitabine administration reduced the generation of these DC and increased vaccine-induced immunity, which rejected about 20% of LLC-OVA and B16-OVA tumors, which are non-responders to anti-PD-1. (unav.edu)

While inflammatory injury drives both fibrogenesis and carcinogenesis, the tolerogenic microenvironment of the liver conveys immunosuppressive effects that encourage tumor growth. (mdpi.com)
The response to immune checkpoint blockade, depends on a pre-existing, CD8 T cell-rich tumor microenvironment. (aacrjournals.org)
Vaccination alone or in combination with anti-PD-1/anti-CTLA4 did not elicit tumor regression nor increase CD8 + T cells in the tumor microenvironment (TME), suggesting the presence of immune-suppressive barriers. (nih.gov)
Regardless of the therapeutic approach, the heterogeneity of pancreatic cancer cells and the complexity of its tumor microenvironment contribute to the emergence of drug resistance. (frontiersin.org)
B cells also regulate the immune response within the tumor microenvironment through the release of cytokines, such as IFN-g, IL-12, or IL-10. (medjouel.com)
It relieved the inhibitory effect of DNMT3A mutation, promoted the phenotypic recovery of the co-cultured macrophages, eliminated resistance, and regulated the immune microenvironment. (frontiersin.org)
Macrophages are the most abundant white blood cells in the immune microenvironment and have a high degree of heterogeneity. (frontiersin.org)
These changes in the tumor microenvironment may lead to tumor cell death and eventually to a long-term memory immune response against tumor antigens. (drugdiscoverynews.com)
There is an extensive body of evidence that demonstrates that modulating the tumor microenvironment is critical to a successful outcome in cancer immunotherapy," added Dr. Sudhir Agrawal, president of Research at Idera. (drugdiscoverynews.com)
Following stimulation, NKT cells lead to activation of both innate and adaptive immune cells in the tumor microenvironment. (msdmanuals.com)
Integrative analyses of similar to 500 mice and similar to 1,000 patients revealed a common MAPK-MYC genetic pathway that accelerated time to progression from precursor states across genetically heterogeneous MM. MYC-dependent time to progression conditioned immune evasion mechanisms that remodeled the BM microenvironment differently. (unav.edu)

Blockade of CTLA-4 by antibodies has potentiated antitumor T-cell responses in both preclinical models and clinical trials. (aacrjournals.org)
By injecting the antibodies in a subcutaneous slow-release delivery formulation in the tumor area, we show that an eight-fold lower dose of antibody is as effective in inducing tumor eradication as systemic delivery. (aacrjournals.org)
These immune-inhibitory effects inhibited synergistic effects of combining our oncoprotein vaccine with immune checkpoint-blocking antibodies. (nih.gov)
Creative Diagnostics, a leading manufacturer and supplier of antibodies, antigens and assay kits, has launched a range of antibodies, antigens and kits against CLDN6 to support researchers worldwide in preclinical and clinical safety/efficacy testing. (supportnumber.uk)
It is currently being investigated for use in novel immunotherapies for the treatment of cancer, including monoclonal antibodies, bispecific antibodies (BsAbs), antibody-drug conjugates (ADCs) and chimeric antigen receptor (CAR) T-cell therapy. (supportnumber.uk)
For instance, the use of CLDN6 antibodies can block tumor growth and prolong the lives of TGCT patients. (supportnumber.uk)
T cell-engaging bispecific antibodies (TCEs) are potent tumor targeting agents that enhance recognition by binding a patient's T cells to proteins expressed on the surface of cancer cells, enabling the T cells to kill the cancer cells. (supportnumber.uk)
Creative Diagnostics now offers a range of antibodies, antigens and kits against CLDN6 to support customers worldwide in their preclinical and clinical safety/efficacy testing. (supportnumber.uk)
Creative Diagnostics is a leading manufacturer and supplier of antibodies, viral antigens, innovative diagnostic components, and critical assay reagents. (supportnumber.uk)
The immunological responses measured throughout the study will include the level of SARS-CoV-2 neutralizing antibodies against SARS-CoV-2 variants of concern (VOC), including the newly identified Omicron VOC, as well as specific T-cell responses. (geovax.com)
GEO-CM02 as a Pan-Coronavirus Vaccine - First-generation SARS-CoV-2 vaccines were designed to encode the spike (S) protein of the SARS-CoV-2 virus with the goal of inducing high levels of neutralizing antibodies. (geovax.com)
However, potential limitations of narrowly focusing on the spike (S) protein are becoming apparent with emerging variants capable of partially escaping neutralization by vaccine induced antibodies. (geovax.com)
While IgA + plasma cells regulate bacterial populations in the gut lumen in steady state, plasma cell-derived tumor-specific IgG1 antibodies mediate cell cytotoxicity and phagocytosis of tumor cells. (medjouel.com)
Anti-PD-1 antibodies (dark green) or anti-PD-L1 antibodies (light green) can prevent the tumor cell from binding PD-1 and thus allow T cells to remain active. (shu.edu)
Restorative antibodies have accomplished considerable success in treating individuals with haematological BIBX 1382 malignancies and solid tumors. (immune-source.com)
The mechanisms of tumor cell killing by antibodies are summarized as the direct action of the antibody payload delivery and specific effects of an antibody within the tumor vasculature and stroma. (immune-source.com)
some cells require the presence of humoral antibodies directed against the tumor cells (antibody-dependent cellular cytotoxicity) to initiate the interactions that lead to the death of tumor cells. (msdmanuals.com)
Redirecting endogenous antibodies in the bloodstream to tumor cells utilizing artificial molecules is a promising strategy to set off anti-tumor immune responses. (kashbiotech.com)
Fc-ARMs efficiently interacted with antibodies in vivo and amassed in tumors. (kashbiotech.com)
Moreover, Fc-ARMs recruited antibodies to suppress tumor progress in a mouse mannequin. (kashbiotech.com)

T cell responses were measured by interferon γ ELIspot assay ex vivo. (bmj.com)
Strong durable T cell responses to 6MHP were detected ex vivo in 0%, 29%, 67%, and 47% of participants on arms A-D, respectively. (bmj.com)
Mainly analyzed by in vitro assays in tumor transplantation models, little is known about their function in autochthonous tumor models in vivo. (mdc-berlin.de)
None of the iMC from the different tumor models suppressed CTL responses in adoptive cell transfer experiments, unless GM-CSF was provided in vivo. (mdc-berlin.de)
The SQZ AAC platform is designed to induce antigen presentation in vivo by deriving antigen carriers from engineering red blood cells (RBCs) with tumor specific antigens and adjuvants. (stockhouse.com)
Its SQZ TAC platform is designed to induce antigen-specific immune tolerance in vivo by utilizing a similar approach to the AAC platform. (stockhouse.com)
In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
Effective cancer immuno- and virotherapies are hindered by a lack of identified tumor-associated antigens (TAAs), poor coverage of the antigenic repertoire expressed by tumors, and difficulties associated with targeting vectors to tumors in vivo , explains Dr. Vile, together with co-lead author Alan Melcher, at the U.K. Leeds Institute of Molecular Medicine and Cancer Research U.K. Clinical Center, and colleagues. (genengnews.com)
Nevertheless, building on the positive aspects of this approach, the researchers postulated that it may be possible to provide a broad antigenic repertoire for in vivo immune selection of relevant tumor-associated antigens by expressing a cDNA library of a normal tissue using a systemically delivered, immunogenic vector. (genengnews.com)
They chose VSV as the vector for delivering and expressing the antigens in vivo. (genengnews.com)
A recombinant oncolytic adenovirus expressing anti-CTLA4 antibody was generated and showed an effective antitumor activity in vivo [16]. (immune-source.com)
Previous data indicated that CpG boosted tumor-specific T-cell responses after in vivo tumor destruction and increased survival after tumor rechallenges. (pasteur.fr)

Recent advances in cancer immunology, highlighted by immune checkpoint inhibitors, have demonstrated that immunotherapy is a viable option in the oncologist's armamentarium. (ndltd.org)
This mechanistically rational antigen selection sequence, effective even for unvaccinated donors, regardless of HLA-haplotype, enables rapid identification of tumor protein regions relevant for cancer immunology, including adoptive immunotherapy, vaccines, and even identification of tumor neo-antigens unique to each patient. (ndltd.org)
In recent years, immunotherapy to activate anti-cancer host immune cells to kill tumors has become a new area of research for the treatment of prostate cancer. (asmepress.com)
As an important component of immunotherapy, cancer vaccines have a unique position in the precise treatment of malignant tumors. (asmepress.com)
In the past decades, immunotherapy has been used to treat prostate cancer through anti-tumor effects driven by immune response. (asmepress.com)
Sipuleucel-T (Provenge®, Dendreon, USA) is an active immune cell-based immunotherapy that induces an immune response against prostate acid phosphatase (PAP). (asmepress.com)
Author information Abstract Immunotherapy is a growing therapeutic strategy in oncology based on the stimulation of innate and adaptive immune systems to induce the death of tumour cells. (ebi.ac.uk)
Cancers induced by human papillomaviruses (HPV) should be responsive to immunotherapy by virtue of expressing the immunogenic oncoproteins E6/E7. (nih.gov)
Moreover, any tumor cells that do manage to evade the initial antitumor immune response are mopped up after a second-line virus-based immunotherapy comprising a different set of antigens. (genengnews.com)
Immunotherapy can fail in patients with cancer when certain cancer cells can hide from the immune system. (lu.se)
However, cDC1 can be compromised in cancer patients and some cancer cells lack these antigen-presenting proteins on their surface, impacting immunotherapy response. (lu.se)
Our experimental models enable the correlation of MM genetic and immunological traits with preclinical therapy responses, which may inform the next-generation immunotherapy trials. (unav.edu)
Background Neoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential targets for vaccination. (unav.edu)

Activated GITR plays a role in directing the antitumor immune response by activating tumor-antigen-specific T effector cells, and abrogating the suppression induced by inappropriately activated T regulatory cells. (biopharminternational.com)

In addition, B cells present tumor-specific antigens via MHCI and MHCII to T cells inducing their anti-tumor effector function. (medjouel.com)

Here, using massively parallel sequencing, we characterize expressed mutations in highly immunogenic methylcholanthrene-induced sarcomas derived from immunodeficient Rag2(-/-) mice that phenotypically resemble nascent primary tumour cells. (nih.gov)
RESULTS: In tumor-implanted mice, the spinal MOR and KOR protein and mRNA expression was down-regulated when compared to that in sham-implanted mice (p (bvsalud.org)
Morphine, nalbuphine, or nalbuphine co-administration with morphine all can extend the paw withdrawal thermal latency (PWL) to radiant thermal stimulation in tumor-implanted mice (p (bvsalud.org)
This affects about 10-15% of leukemic cells in mice, but this is enough of the pool of antigen presenting cells to induce anti-tumor immune responses. (targetedonc.com)
Mathematical model approach to describe tumour response in mice after vaccine administration and its applicability to immune-stimulatory cytokine-based strategies. (ebi.ac.uk)
This type of mathematical approaches may be helpful to maximize the information obtained from experiments in mice, reducing the number of animals and the cost of developing new antitumor immunotherapies. (ebi.ac.uk)
Leveraging a transgenic mouse model of HPV-derived cancers, K14HPV16/H2b, we demonstrated that a potent nanoparticle-based E7 vaccine, but not a conventional "liquid" vaccine, induced E7 tumor antigen-specific CD8 + T cells in cervical tumor-bearing mice. (nih.gov)
Underlining the requirement of an intact host immune system for the full therapeutic benefit of dolastatins, the anti-tumour effect was far less pronounced in immune-compromised mice. (biomedcentral.com)
First, MB49 expresses the male antigen, H-Y. Thus, when grown in syngeneic female mice, H-Y provides a surrogate tumor-specific antigen for study. (jefferson.edu)
Consequently, growth of MB49 in IL-10 knockout (KO) mice, whose infiltrating cells are unable to produce IL-10, allows for the removal of the IL-10 normally associated with this tumor. (jefferson.edu)
The team cloned a cDNA library from normal human prostate, which they termed altered self antigen and epitope library (ASEL) into VSV, and systemically injected the antigen-expressing vector into normal experimental mice. (genengnews.com)
They then went on to test the virus-expressed human cDNA library in mice with established prostate tumors. (genengnews.com)
Nine intravenous injections of ASEL were sufficient to cure over 80% of mice with the prostate tumors, with no detectable autoim-mune prostatitis. (genengnews.com)
They first tried a second vaccination comprising virally expressed immune-escape epitope libraries (IEELs) constructed using cDNA from the recurrent tumors of ASEL-treated mice. (genengnews.com)
To understand the role of endogenous immune system in the antitumor response, the investigators compared activity in immune-competent mice with activity in immune-compromised mice. (targetedonc.com)
The investigators used cured mice from the immune-competent models and rechallenged them with antigen negative tumors to test this hypothesis. (targetedonc.com)
We could show that B cells exert an important role by using B cell-deficient mice (JHT mice), which were completely resistant to AOM/DSS-induced inflammation as well as CRC development. (medjouel.com)
reported laser irradiation of photodynamic therapy (PDT) to treat mice subcutaneously inoculated with CT26.CL25 colon carcinoma cells inducing local remission and antigen-specific immune response systemically, promoting regression of a remote and untreated tumor 9 . (medicalrecords.com)
One limitation of the study is that the tumor model used is not a clinically relevant tumor, and instead represents an artificially-induced cancerous state in the subject mice. (medicalrecords.com)
Tumors shrank in 6 mice of 11 mice in the aFP group and 8 mice of 11 mice in the aFP + anti-PD-1 group, but such shrinkage occurred in only 1 mouse (9%) from the anti-PD-1 group or does not occur in the control group (Fig. 1b ). (medicalrecords.com)
Albert Calmette and Camille Guérin developed an attenuated nonpathogenic strain of Mycobacterium bovis bacterial vaccine against tuberculosis, labeled Bacillus Calmette-Guérin, or BCG, that was recognized through experiments with mice to be effective against tumors. (biomedcentral.com)
Depletion of pDCs or applying this model in type I IFN receptor-deficient mice abrogated CpG-mediated responses. (pasteur.fr)

Based on the spatial structure and regulatory properties of CLDN6, the exploration or design of CLDN6-targeted drugs to positively regulate CLDN6-related signaling molecules and interfere with tumor progression is of great value for early diagnosis and precision treatment of tumors. (supportnumber.uk)

Irreversible electroporation is a predominantly nonthermal and adjacent structure-sparring ablation method that has been proven safe and efficient in the treatment of tumors in the liver, pancreas, and prostate. (rsna.org)
However, FP is not used for the treatment of tumors and no studies to date have investigated production of systemic effects using FP methods. (medicalrecords.com)

With the possibility that BCG may exhibit a systemic immune response, future research may be warranted regarding the use of BCG in the fight against viruses such as SARS-CoV-2 and various immunological disorders. (healthybladderclub.com)
Our data highlighted a link between HPV-induced cancers, systemic amplification of myeloid cells, and the detrimental effects of myeloid cells on CD8 + T-cell activation and recruitment into the TME. (nih.gov)
the potent combination of high-voltage electrical pulses with immune cascade-enhancing drugs may offer a bridge between local-regional and systemic treatments in oncology. (rsna.org)
Researchers claim systemic vaccination with broad antigenic repertoire from normal prostate stimulates anticancer immune response but not autoimmunity. (genengnews.com)
Idera Pharmaceuticals Inc. has announced new data demonstrating enhanced systemic antitumor activity in preclinical cancer models. (drugdiscoverynews.com)
In preclinical models, previously we have seen compelling systemic antitumor effects with intratumoral IMO-2125 monotherapy, in combination with inhibitors of CTLA-4, PD-1 and now IDO. (drugdiscoverynews.com)
As Doody explained, "Tumor regression was not only observed in the injected tumor but also in the uninjected tumor, essentially creating a systemic response. (drugdiscoverynews.com)
These studies suggest that IMO-2125 can induce memory T cell responses, leading to a robust systemic antitumor activity. (drugdiscoverynews.com)
The disease is undoubtedly an all natural OV for solid tumor therapy in center trials and displays minimal side-effects with systemic administration [3 4 Lately the toxicity biodistribution and dropping of NDV in nonhuman primates under intravenous shot were examined demonstrating the protection for intravenous administration [5]. (immune-source.com)
OncoVEXGM-CSF a recombinant HSV expressing GM-CSF in phase III trial for treatment of melanoma was proved to eliminate malignancy cells by inducing local and systemic antigen-specific T cell reactions and reducing suppressive immune cell populations [12]. (immune-source.com)
challenges have focused primarily on local responses in IgE is strongly associated with the prevalence of asthma, it the skin and have pretty much ignored any systemic raises the interesting question of whether allergen sensitization effects. (cdc.gov)
It is well established that the systemic immune ated with a lesser asthma severity. (cdc.gov)
Brinkman et al5 examined whether the presence and foods.1,2 However, much less is known about the poten- severity of AD was predictive of the occurrence and mag- tial influence that skin challenges have on the systemic nitude of early and late asthmatic responses to inhaled immune response, in particular whether sensitization allergens. (cdc.gov)

Although many immune components that participate in this process are known, its underlying mechanisms remain poorly defined. (nih.gov)
In this paper, we have developed a population semi-mechanistic model able to characterize the mechanisms implied in tumour growth dynamic after the administration of CyaA-E7, a vaccine able to target antigen to dendritic cells, thus triggering a potent immune response. (ebi.ac.uk)
It unlocks novel dimensions by uncovering elusive cell populations and tumor heterogeneities for early detection, unraveling mechanisms of treatment resistance, tailoring therapies to individuals, and illuminating metastasis and cachexia pathways, thereby opening fresh avenues for preventive strategies. (frontiersin.org)
Recent studies implicate a fundamental role of B cells in shaping anti-tumor responses through several mechanisms. (medjouel.com)
Antibody-independent mechanisms such as antigen presentation, cytokine production, direct cytotoxicity, and indirect effects through modulation of other immune cells have been demonstrated to be of great importance. (medjouel.com)
Our results suggest that one of the mechanisms related to the success of BCG in reducing tumor recurrence in NMIBC may be related to the negative control of PD1 and PD-L1 in tumor cells. (biomedcentral.com)
Conversely, malignant cells evolve mechanisms that allow them to evade immune recognition. (biomedcentral.com)
To enhance vaccine potency and improve thus responses to ICI, we analyzed the gene expression profile of an immunosuppressive dendritic cell (DC) population induced during vaccination, with the goal of identifying druggable inhibitory mechanisms. (unav.edu)

What Kortylewski found was that a rapid regression in leukemia was linked to blocking STAT3 in these AML cells, caused by immune mediated circulating tumor DNA responses. (targetedonc.com)
Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
Together, these studies identify T cell-mediated tumor regression as the mechanism through which a plant-derived essential oil diminishes established tumor burden. (biorxiv.org)
SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)
Three intravenous ASEL injections typically induced initial tumor regression, but with subsequent aggressive tumor recurrence. (genengnews.com)
The phenomenon promoting regression of a remote and untreated tumor was not observed when they employed CT26 wild type (CT26WT) undifferentiated colon carcinoma cells, which are beta-gal negative parental carcinoma of CT26.CL25 cells. (medicalrecords.com)
According to Doody, preclinical studies using IMO-2125 either as a single-agent or in combination with several checkpoint inhibitors-such as anti-CTLA-4, anti-PD-1 and IDO-1 inhibitor-have shown robust tumor regression. (drugdiscoverynews.com)

To evaluate the clinical activity, tolerability and anti-tumor activity of AM0010 alone or in combination with chemotherapy or immune checkpoint inhibitors a multi-basket phase 1 study was conducted. (aacrjournals.org)
Although there are few studies searching for the role of BCG over PD1 and PD-L1, many clinical trials are in course using the immune checkpoint inhibitors together with BCG as a new regime to treat NMIBC. (biomedcentral.com)
IDO is one of several immune checkpoints involved in tumor immune escape, and IDO-1 inhibitors are currently in clinical development, according to the company. (drugdiscoverynews.com)
Combination with checkpoint inhibitors will potentiate IMO-2125's antitumor activity. (drugdiscoverynews.com)
Vaccination using optimized strategies may increase response rates to immune checkpoint inhibitors (ICI) in some tumors. (unav.edu)

The result is the immunogenic cell death of tumor cells, accompanied by an auto-vaccination preventing the recurrence of cancer. (pipelinereview.com)
A single normal cell randomly acquires a series of mutations that allows it to proliferate and to be transformed into a cancer cell (i.e., founding clone), which initiates tumor progression and recurrence. (nature.com)
We have previously shown that tumor founding clone mutations are able to predict tumor recurrence. (nature.com)
To address the problem of tumor recurrence, the researchers evaluated combinations of vaccination with differ-ent libraries. (genengnews.com)
2017 ). PD-L1 is expressed by high-grade urothelial carcinoma, related with tumor recurrence and poorer survival in organ-confined disease (Nakanishi et al. (biomedcentral.com)
It has been proved to have a beneficial treatment effect on BIBX 1382 prevention of tumor recurrence in individuals with HCC [23 24 We generated a mouse-human chimeric cHAb18 antibody that derived from murine HAb18 and showed inhibition of HCC cell. (immune-source.com)

A central tenet of cancer immunoediting is that T-cell recognition of tumour antigens drives the immunological destruction or sculpting of a developing cancer. (nih.gov)
The innate immune system includes macrophages, dendritic cells (DC), and natural killer (NK) cells, which respond quickly to an immunological threat. (nature.com)
They found that polyclonal immune responses could potentially be generated by productive CAR T cell-mediated induction to address tumor heterogeneity and immunological memory to reduce the potential for tumor relapse. (targetedonc.com)

The main target and effector cells of the CTLA-4 blockade treatment in the studied tumor models are tumor-specific endogenous CD8 + T cells that are capable of eradicating also distant tumors, whereas CD4 + T cells do not play a prominent role in the antibody-mediated tumor eradication. (aacrjournals.org)
Hot spot" peptide Ag-specific T-cells preferentially recognized endogenous tumor derived MUC1, either in MUC1 expressing tumor cell killing assays (p=0.038, compared to non-peptide Ag-specific T-cells) or as MUC1 tumor lysate when pulsed onto restimulatory PBMC (p=0.022 and 0.025, for CD4+ and CD8+ T-cells, respectively, compared to T-cells directed against peptides from non-hot spot regions). (ndltd.org)
The presence of tumor-associated antigens induces a potent and long-lasting antigen-specific T-cell response, breaking the immune system's tolerance to endogenous autoantigens and producing an effective anti-tumor effect. (supportnumber.uk)
While CAR T cells were detected, the majority of these immune cells were from the host immune system showing endogenous CD3 and CD14 myeloid population," Brown explained. (targetedonc.com)
In addition to the endogenous immune cells, Brown said there were also spikes of inflammatory cytokines that coincided with each infusion of CAR T cells. (targetedonc.com)
To our surprise, we saw that CAR T cells mediated superior antitumor responses in immune-competent mouse models, suggesting that CAR T cells may stimulate an endogenous T-cell response or antitumor response," Brown said. (targetedonc.com)

Sipuleucel-T consists of autologous peripheral blood mononuclear cells including antigen presenting cells (APCs). (asmepress.com)

RCC is an immunogenic tumor, and spontaneous regressions have been documented. (medscape.com)

This provided the effective, clinical treatment for the multi-drug resistance tumour. (uwi.edu)
It is the first anti-glucocorticoid-induced tumor necrosis factor receptor (GITR) drug candidate to enter human clinical trials. (biopharminternational.com)
TL-532 also demonstrated its remarkable ability to overcome Immune Checkpoint Inhibitor (ICI) tumor-resistance, thus increasing the clinical landscape for ICI combination treatment. (pipelinereview.com)
We hypothesised that its sustained clinical responses could be related to the stimulation of an anti-cancer immune response. (biomedcentral.com)
Our data reveal a novel mechanism of action for dolastatins and provide a strong rationale for clinical treatment regimens combining dolastatin-based therapies, such as brentuximab vedotin, with immune-based therapies. (biomedcentral.com)
This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical oncology to treat solid tumors with irreversible electroporation (IRE) and electrochemotherapy (ECT). (rsna.org)
GEO-CM04S1 for Immunocompromised Patients - GEO-CM04S1 is being studied in an ongoing Phase 2 clinical trial (NCT04977024) to evaluate its safety and immunogenicity, compared to the Pfizer/BioNTech mRNA-based vaccine, in patients who have previously received either an allogeneic hematopoietic cell transplant, an autologous hematopoietic cell transplant or chimeric antigen receptor (CAR) T cell therapy. (geovax.com)
We are extremely pleased to demonstrate the ability of TG4050 to effectively prime the immune system of the first patients who received this novel treatment and observe first signals of clinical activity. (nec.com)
We are working hard to complete the studies to further confirm these findings and generate additional immune and clinical data. (nec.com)
We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). (cdc.gov)
Our findings highlight the importance of innate immune response against Ebola virus and show the association between KIRs and the clinical outcome of EVD. (cdc.gov)

Despite the activity of effector cells, host immunoreactivity may fail to control tumor occurrence and growth. (msdmanuals.com)
NK cells, among other cells, are key effector cells of the innate immune system and play a crucial role in the antiviral response. (cdc.gov)

The company is hoping BNT111, which used a fixed combination of mRNA-encoded, tumor-associated antigens to target the cancer cells, will demonstrate the same kind of success as the COVID-19 vaccine. (biospace.com)
Prostate acid phosphatase (PAP) is expressed in approximately 95% of prostate cancers and is mainly limited to prostate tissue, which is a target for prostate cancer tumor vaccine development. (asmepress.com)
The mathematical model developed presented the following main components: (1) tumour progression in the animals without treatment was described with a linear model, (2) vaccine effects were modelled assuming that vaccine triggers a non-instantaneous immune response inducing cell death. (ebi.ac.uk)
Researchers have developed a virus-based vaccine expressing a broad spectrum of undefined antigens from normal human prostate tissue that they claim completely eradicates established mouse prostate tumors in experimental animals. (genengnews.com)
Reporting in Nature Medicine , the team in the U.S. and U.K. that developed the approach says the vaccine can be delivered systemically without the need for tumor targeting, appears to have no side effects, and doesn't induce autoimmunity. (genengnews.com)
Our results indicate that gemcitabine is a suitable combination therapy with vaccines aimed at enhancing PD-1 therapies by targeting vaccine-induced immunosuppressive DC. (unav.edu)

In addition, recurrent tumors expressed genes associated with an epithelial-to-mesenchymal-type transition, and had lost, or at least reduced, expression of mouse homologs of the human RNAs encoding prostate-specific antigens in the ASEL. (genengnews.com)
KEGG enrichment and gene set enrichment analysis (GSEA) showed that a large number of genes were enriched in inflammatory immune-related pathways, such as the toll-like receptor signaling pathway. (frontiersin.org)
The phosphorylation of pRB, and relief of transcriptional repression by pRB induces genes involved in the induction of S-phase entry. (shu.edu)
Genetic studies of the families at high risk for developing renal cancer led to the cloning of genes whose alteration results in tumor formation. (medscape.com)
These genes are either tumor suppressors (VHL, TSC) or oncogenes (MET). (medscape.com)
From experimentally validated target genes of these 86 miRNAs, pan-sensitive and pan-resistant genes with concordant mRNA and protein expression associated with in-vitro drug response to 19 NCCN-recommended breast cancer drugs were selected. (cdc.gov)

After cytokine-induced killer cells (CIK) were co-cultured with dendritic cells (DC) loaded with multi-drug resistance tumor antigen, the higher antitumour immune response was evaluated to multi-drug resistance tumor expressed as the same tumour antigen. (uwi.edu)
Cytokine-induced killer cells (CIK) are capable of lysing tumor cell and recognizing these cells in a non-MHC restricted fashion. (uwi.edu)
Furthermore, other cells at the interface of the innate and the adaptive immune system (e.g cytokine-induced killer cells (CIK) or invariant natural killer T-cells (iNKT)) are important mediators in antitumor-, autoimmune-, and antimicrobial responses and tumor surveillance. (nature.com)

TRX518 is a targeted T cell immunomodulator that activates GITR (glucocorticoid-induced tumor necrosis factor receptor) found on multiple types of T cells and other immune cells. (biopharminternational.com)
We hypothesized that adding toll-like receptor 3 agonist polyICLC to an incomplete Freund's adjuvant (IFA) would be safe and would support strong, durable CD4 + T cell and Ab responses. (bmj.com)
T cell receptor mediated activation of CD8 T cells induces the expression of IL-10 receptors on these cells. (aacrjournals.org)
some parts of the patient's tumor expressed low or negative levels of interleukin-13 receptor alpha 2 (IL13Rα2), but other parts expressed medium or high levels. (targetedonc.com)
PD-L1 is a ligand of the co-inhibitory receptor PD1 that has been shown to be expressed by tumor cells of distinct origin related to unfavorable prognosis. (biomedcentral.com)
PD-L1 is a ligand of the co-inhibitory receptor PD1 that under physiologic conditions is constitutively expressed by activated T and B-lymphocytes, DCs, monocytes, mesenchymal stem cells, bone marrow-derived mast cells and other immune privileged organs. (biomedcentral.com)
It has an immune receptor tyrosine based inhibitory motif and an immune receptor tyrosine-based switch motif (Zak et al. (biomedcentral.com)
The signaling inhibitory antibody quickly induces ligand-independent receptor clustering and internalization via each caveolin and clathrin-mediated pathways. (kashbiotech.com)
The non-inhibitory antibody additionally effectively endocytoses through clathrin with out inducing receptor clustering however with slower lysosomal co-localization kinetics. (kashbiotech.com)
NOTCH3-ADCs internalize into receptor and ligand cells impartial of signaling and induce cell dying in each cell sorts representing an atypical mechanism of ADC cytotoxicity. (kashbiotech.com)

Ultimately, ADCs using dolastatins induce DC homing and activate cellular anti-tumour immune responses in patients. (biomedcentral.com)

When combining dolastatins with tumour-antigen-specific vaccination or blockade of the PD-1/PD-L1 and CTLA-4 co-inhibitory pathways, we observed substantial therapeutic synergies. (biomedcentral.com)
Single-cell transcriptomics and functional assays defined a high ratio of CD8(+) T cells versus T-reg cells as a predictor of response to immune checkpoint blockade (ICB). (unav.edu)

Cancer immunoediting, the process by which the immune system controls tumour outgrowth and shapes tumour immunogenicity, is comprised of three phases: elimination, equilibrium and escape. (nih.gov)
These results demonstrate that the strong immunogenicity of an unedited tumour can be ascribed to expression of highly antigenic mutant proteins and show that outgrowth of tumour cells that lack these strong antigens via a T-cell-dependent immunoselection process represents one mechanism of cancer immunoediting. (nih.gov)
However, poor immunogenicity of tumor-associated antigens typically fails to induce an environment friendly immune response towards the tumor. (signetlabs.com)
Strikingly, when supported by NEC's powerful prediction tool, the myvac ® viral vector used in TG4050, which has been genetically optimized to improve immunogenicity and peptides presentation, induced robust and consistent response against class I and class II epitopes. (nec.com)
The safety profile and early immunogenicity data against multiple patient-specific tumor targets in the first patients is a testimony of TG4050's potential and of the complementary synergies between the two companies. (nec.com)

Data_Sheet_1.pdf (513K) GUID:?514B8128-1B6A-4BCF-ADFD-8945AF1CB772 Abstract The lysosome has a key role in the presentation of lipid antigens by CD1 molecules. (clinical-research-informatics.com)
Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. (msdmanuals.com)

However, our current understanding of tumour antigens comes largely from analyses of cancers that develop in immunocompetent hosts and thus may have already been edited. (nih.gov)
Most patients carry a missing or damaged p53 gene, a tumor suppressor whose activity is impaired in almost 50% of all cancers. (nature.com)
Interleukin (IL)-10 is a potent immunosuppressive cytokine that is found in elevated quantities both at the tumor site and systemically in a variety of cancers. (jefferson.edu)
Increasingly, renal cell cancers are diagnosed at an earlier stage, and nephron-sparing surgery and thermal ablation are gaining acceptance as a treatment of choice for smaller tumors. (medscape.com)

Effective immune surveillance of patients with hematologic malignancies such as leukemia is mediated by cellular and noncellular arms of the innate and adaptive immune system. (nature.com)
ECT uses HVEPs to transiently increase membrane permeability, enhancing cellular cytotoxic drug uptake in tumors. (rsna.org)
We focused particularly on harnessing reprogramming, or direct cellular reprogramming, to induce antigen presentation in cancer cells. (lu.se)
Intact antibody can also result in antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity which improve the antitumor restorative effect greatly. (immune-source.com)
Cytokines The immune system consists of cellular components and molecular components that work together to destroy antigens (Ags). (msdmanuals.com)

Thus, whether B cells promote or inhibit tumor growth depends on different variables, such as temporal and spatial settings, as well as on the composition of B cell subsets. (medjouel.com)
In contrast, suppressor T cells inhibit the immune response against tumors. (msdmanuals.com)

Th1 cytokines (IL-2, tumor necrosis factor, IL-12, and IFN-γ) and Th2 cytokines (IL-4, IL-5, IL-6, and IL-10) along with IL-8 and IL-17 induce antitumor activity mediated by cytotoxic T lymphocytes, natural killer cells (NK), neutrophils, and macrophages. (biomedcentral.com)

Predicted epitopes were synthesized in the form of synthetic long peptides and tested in immune system sensitization assays involving unfractionated peripheral blood mononuclear cells (PBMC). (ndltd.org)
antigens, methods, and interpretation criteria for these assays differ from those for IGRAs approved previously by FDA. (cdc.gov)
1988. Species-specific response to the rodent carcinogens 1,2-dimethylhydrazine and 1,2-dibromo-3-chloropropane in rodent bone-marrow micronucleus assays. (cdc.gov)

Given the potent suppressive properties of this cytokine, we hypothesized that its presence at the site of progressively growing tumors represents an immune escape mechanism utilized by tumors to avoid detection by the immune system. (jefferson.edu)

Cryoablation for breast cancer is typically only possible for small tumors. (wikipedia.org)
The company aims to use its mRNA technology to harness the immune system's power against cancer and infectious diseases. (biospace.com)
Libtayo, a monoclonal antibody, has previously been approved to treat metastatic cutaneous squamous cell carcinoma, advanced basal cell carcinoma, and patients with advanced non-small-cell lung cancer whose tumors have high PD-L1 expression. (biospace.com)
We also demonstrate that cancer immunoediting of d42m1 occurs via a T-cell-dependent immunoselection process that promotes outgrowth of pre-existing tumour cell clones lacking highly antigenic mutant spectrin-β2 and other potential strong antigens. (nih.gov)
We use different preclinical mouse models of cancer to investigate the local administration of CTLA-4 blocking antibody and its effect on cancer progression and the antitumor T-cell response. (aacrjournals.org)
TRX518 is a monoclonal antibody designed to enhance the immune system by enabling T cells to more effectively attack cancer cells. (biopharminternational.com)
TRX518 is designed to have activating and sustaining effects on T cells for enhancing the immune system's responses against cancer cells, including responses that may occur with TRX518 alone, as well as complementary responses in combination with other cancer therapies including vaccines. (biopharminternational.com)
BUFFALO, NY- November 17 , 2023 - A new research paper was published in Oncoscience ( Volume 10 ) on November 10, 2023, entitled, " An immunoinformatics assessment of the cancer testis antigen, DDX53, as a potential early esophageal cancer antigen . (biotechnews.com.au)
To better understand the potential positive and negative impacts of T-cells in ESCA, we recovered TCR recombination reads from the TCGA-ESCA whole exome sequence (WXS) files, obtained the TCR CDR3 AA sequences, and assessed the chemical complementarity of those sequences with CTAs, as those antigens have been characterized by many approaches over decades as candidate cancer antigens. (biotechnews.com.au)
Chemical complementarity of the ESCA TCR CDR3s and the cancer testis antigen DDX53 represented a disease-free survival (DFS) distinction, whereby the upper fiftieth percentile complementarity group correlated with worse DFS. (biotechnews.com.au)
Background: The success of and the durability of immune therapy of cancer is thought to depend on the activation and expansion of tumor reactive and infiltrating CD8+ T cells. (aacrjournals.org)
We analyzed iMC in three SV40 large T (Tag)-driven conditional autochthonous cancer models with drastically different immune status: 1. (mdc-berlin.de)
Early Tag-specific CTL competence and rare stochastic Tag activation leading to sporadic cancer, which induces an aberrant immune response and CTL tolerance. (mdc-berlin.de)
Prostate cancer is one of the most common malignant tumors of the urinary system. (asmepress.com)
Cancer vaccines use tumor cell-associated antigens to induce a specific anti-tumor immune response that is durable and robust. (asmepress.com)
The active components of Sipuleucel-T are autologous APCs and PAP-GM-CSF, in addition to T cells, B cells, natural killer cells, and other cells that specifically bind to PAP expressed in prostate cancer tissue to kill tumor cells. (asmepress.com)
However, advanced forms of cervical cancer, driven by HPV, are poorly responsive to immune response-enhancing treatments involving therapeutic vaccination against these viral neoantigens. (nih.gov)
Patients with cervical cancer have poor dendritic cell functions, have weak cytotoxic lymphocyte responses, and demonstrate an accumulation of myeloid cells in the periphery. (nih.gov)
We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. (biorxiv.org)
Her research involves direct reprogramming approaches, which function like a Trojan horse, enabling cancer cells to be targeted by the immune system. (lu.se)
By using direct reprogramming strategies, I could induce the expression of tumor antigens on the surface of cancer cells, making them visible to the immune system again. (lu.se)
when it comes to cancer they are critical as they present tumor antigens to the killer cells of the immune system and orchestrate the anti-tumor immune response. (lu.se)
Direct reprogramming strategies with cDC1-specific factors can induce antigen-presentation in cancer cells, making cancer cells visible to the immune system and easier to fight. (lu.se)
IL-10, TGF-β, chronic infection and cancer induce PD1 expression by different cytokines and is a characteristic of exhausted T cells (Wherry & Kurachi, 2015 ). (biomedcentral.com)
Accumulation of p27 in the nucleus, therefore, blocks cell cycle progression of T-lymphocytes that are being induced to act against cancer antigens. (shu.edu)
In the time since then, the world of utilizing the immune system in the battle against cancer has emerged in a different light. (drugdiscoverynews.com)
In contrast to CTLs, NK cells lack receptors for antigen detection but can still recognize normal cells infected with viruses and cancer cells. (msdmanuals.com)
Randomized, Open Label Phase 3 study of SAR408701 versus Docetaxel in Previously Treated metastatic non-squamous Non-Small Cell Lung Cancer patients with CEACAM5 positive tumors. (who.int)
Six miRNAs had concordant expression in both tumors and breast cancer patient blood samples compared with the normal control samples. (cdc.gov)
Multi-omics biomarkers of response to the discovered drugs were identified using human breast cancer cell lines. (cdc.gov)
This signature provided significant prognostic stratification in The Cancer Genome Atlas breast cancer patients (n = 1100), as well as basal-like and luminal A subtypes, and was associated with distinct immune infiltration and activities. (cdc.gov)
1990. The effect of mild stress on DMH-induced colorectal cancer. (cdc.gov)

Vaccination with IFA+ polyICLC (arm C) also showed promise for enhancing T cell and Ab responses. (bmj.com)
The Mayo Clinic's Richard Vile, M.D., and colleagues, describe their findings in a paper titled "Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors. (genengnews.com)

Background Peptide vaccines designed to stimulate melanoma-reactive CD4 + T cells can induce T cell and antibody (Ab) responses, associated with enhanced overall survival. (bmj.com)
IL-10 stimulates the antigen mediated cytotoxicity, survival and proliferation of intra-tumoral CD8+ T cells and simultaneously dampens chronic inflammation. (aacrjournals.org)
IL-10 activates with STAT3 an essential survival and proliferation signal in antigen activated CD8 T cells. (aacrjournals.org)
CRC patients with tumors highly infiltrated by CD20 + B cells display significantly improved survival, which suggests an anti-tumor role of B cells. (medjouel.com)
The possibility of disease-free survival increases after resection of primary tumor and excision of isolated metastasis. (medscape.com)
Twelve miRNAs showed concordant expression in tumors vs. normal breast tissues and patient survival (n = 1093), with seven as potential tumor suppressors and five as potential oncomiRs. (cdc.gov)

Interferon- belongs to the family of cytokine proteins and works to pleiotropically impede tumor cell growth. (healthybladderclub.com)
Using MB49, we demonstrate that tumor-induced IL-10 inhibits the generation of a type I immune response against a tumor antigen as measured by Interferon (IFN)-γ production, cytotoxic T lymphocyte (CTL) generation, and delayed type hypersensitivity (DTH) reaction. (jefferson.edu)
This was demonstrated by greater proliferative potential on the autologous tumor, greater interferon gamma (IFNγ) production, and the ability to target and kill the patient's tumor. (targetedonc.com)
Macrophages can kill specific tumor cells when activated by a combination of factors, including lymphokines (soluble factors produced by T cells) and interferon. (msdmanuals.com)

ER stress triggers Unfolded protein response (UPR) that protects against ER stress by decreasing unfolding of proteins. (helsinki.fi)
These antigens may be cell surface proteins or may be intracellular proteins (eg, TAAs) that are expressed on the surface in combination with class I major histocompatibility complex (MHC) molecules. (msdmanuals.com)

AND c) Participant with EGFR sensitizing mutation or BRAF mutation or ALK/ROS alterations must be able to demonstrate progression of the disease on approved treatments for these conditions, in addition to platinum-based chemotherapy and immune checkpoint inhibitor. (who.int)

Tumors frequently induce immature myeloid cells (iMC), which suppress specific and unrelated cytotoxic T lymphocyte (CTL) responses and are termed myeloid derived suppressor cells (MDSC). (mdc-berlin.de)

Expressing cell surface molecules such as programmed death ligand-1 (PD-L1) and CTLA-4, tumor cells interact with the receptors on T cells mimicking the signals released by healthy cells, resulting in inactivation of immune system (Boussiotis, 2016 ). (biomedcentral.com)

The proposed model structure was successfully applied to describe antitumor effect of IL-12, suggesting its applicability to different immune-stimulatory therapies. (ebi.ac.uk)
In addition, a simulation exercise to evaluate in silico the impact on tumour size of possible combination therapies has been shown. (ebi.ac.uk)
Unlike alternative ablative therapies, electroporation does not affect the structural integrity of surrounding tissue, thereby enabling tumors in the vicinity of vital structures to be treated. (rsna.org)

Therefore, a phenotypical and functional characterization of B cells in CRC tumor initiation and progression is of great interest with a possible therapeutic benefit. (medjouel.com)

Such vaccines tend to produce an immune response quickly - in less than 14 days - with only mild side effects. (geovax.com)
Such patients have often shown a weak antibody response after receiving currently available COVID-19 vaccines. (geovax.com)

The antitumor activity is the result of intratumoral administration of IMO-2125 in combination with an inhibitor of the immunosuppressive enzyme, indoleamine-pyrrole 2,3-dioxygenase (IDO1). (drugdiscoverynews.com)

In oncology, it is developing cell therapy platforms that are based on directing tumor antigen-specific immune activation via engineered antigen presentation. (stockhouse.com)

Using class I prediction algorithms, we identify mutant spectrin-β2 as a potential rejection antigen of the d42m1 sarcoma and validate this prediction by conventional antigen expression cloning and detection. (nih.gov)
The team's previous work had already shown that killing normal cells in situ using the adjuvant hsp70 generated T cell responses to antigens that mediated rejection of tumors of the same histological type. (genengnews.com)
B16-OVA tumors benefited from a synergistic effect, reaching 75% of tumor rejection, but higher levels of exhausted T-cells in LLC-OVA tumors co-expressing PD-1, LAG3 and TIM3 precluded similar levels of efficacy. (unav.edu)

Cytotoxic T lymphocytes (CTLs) recognize antigens on target cells and lyse these cells. (msdmanuals.com)

EVs were characterized by transmission electron microscopy and fluorescence nanoparticle tracking analysis, and EV surface protein profiles were analyzed by multiplex bead-based flow cytometry to identify tumor- or immune system-related EVs of AML, ALL, CLL, and healthy samples. (nature.com)
To increase the immune response to PAP, it is activated by adding PAP and the recombinant fusion protein of immune activator GM-CSF (PAP-GM-CSF) at a specific stage of cell culture. (asmepress.com)

Fifteen genetically diverse models developed bone marrow (BM) tumors fulfilling MM pathogenesis. (unav.edu)
Re-evaluation of 1,2-dimethylhydrazine in the mouse bone marrow micronucleus assay: Observation of a positive response. (cdc.gov)

CLDN6 expression is associated with prognosis in patients with a variety of tumors. (supportnumber.uk)
The World Health Organization (WHO) classification of gliomas is used to define the type and grade of tumor, but the prognosis and response to treatment may vary among tumors even in the same subtype of tumor. (surgicalneurologyint.com)
CD147 is definitely over-expressed in HCC cells and involved in tumor cell invasion [17] and closely related to prognosis in individuals with HCC [18-22]. (immune-source.com)

Anatomy27

Organisms15

Diseases36

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Phenomena and Processes47

Disciplines and Occupations1

Information Science3

Health Care4

Immunity21

Microenvironment11

Antibodies20

Vivo12

Immunotherapy13

Activating tumor-antigen-specific1

Present tumor-specific antigens1

Mice22

Signaling molecules1

Treatment of tumors2

Systemic13

Mechanisms8

Regression7

Inhibitors5

Recurrence6

Immunological3

Endogenous6

Including antigen prese1

Immunogenic Tumor1

Clinical11

Effector cells2

Vaccine6

Genes6

Cytokine-induced killer cells3

Receptor10

Anti-tumour1

Blockade2

Immunogenicity5

Lipid antigens2

Cancers4

Cellular5

Inhibit2

Necrosis factor1

Assays3

Potent1

Cancer32

Vaccination2

Survival6

Interferon4

Proteins2

Demonstrate1

Cytotoxic T lymphocy1

Receptors1

Therapies3

Progression is of great1

Vaccines2

Immunosuppressive1

Oncology1

Rejection3

Lymphocytes1

Protein2

Bone marrow2

Prognosis3